O60783 (RT14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
28S ribosomal protein S14, mitochondrial
Short name=MRP-S14
Short name=S14mt

Gene names

Name:

MRPS14

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	128 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins By similarity. UniProtKB Q6B860
Subcellular location	Mitochondrion.
Sequence similarities	Belongs to the ribosomal protein S14P family.

Ontologies

Keywords
Cellular component	Mitochondrion
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Non-traceable author statement Ref.4. Source: UniProtKB
Cellular_component	mitochondrial ribosome Non-traceable author statement Ref.4. Source: UniProtKB nuclear membrane Inferred from direct assay. Source: HPA
Molecular_function	structural constituent of ribosome Traceable author statement Ref.4. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
DDX56	Q9NY93	1	EBI-1045956,EBI-372376

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 128	128	28S ribosomal protein S14, mitochondrial		PRO_0000131013

Sequences

	Sequence		Length	Mass (Da)
	O60783 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: FFF3F3C70214EDE4	FASTA	128	15,139
	10 20 30 40 50 60 MAAFMLGSLL RTFKQMVPSS ASGQVRSHYV DWRMWRDVKR RKMAYEYADE RLRINSLRKN 70 80 90 100 110 120 TILPKILQDV ADEEIAALPR DSCPVRIRNR CVMTSRPRGV KRRWRLSRIV FRHLADHGQL SGIQRATW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Rhodes S. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow.
[4]	"A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins." Koc E.C., Burkhart W., Blackburn K., Moseley A., Koc H., Spremulli L.L. J. Biol. Chem. 275:32585-32591(2000) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL049705 mRNA. Translation: CAB41269.1. Z99297 Genomic DNA. Translation: CAB16601.1. BC009788 mRNA. Translation: AAH09788.1.
IPI	IPI00005050.
RefSeq	NP_071383.1. NM_022100.2.
UniGene	Hs.654858.
3D structure databases
ProteinModelPortal	O60783.
ModBase	Search...
Protein-protein interaction databases
IntAct	O60783. 3 interactions.
STRING	9606.ENSP00000420714.
Proteomic databases
PaxDb	O60783.
PeptideAtlas	O60783.
PRIDE	O60783.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000476371; ENSP00000420714; ENSG00000120333.
GeneID	63931.
KEGG	hsa:63931.
UCSC	uc001gkk.3. human.
Organism-specific databases
CTD	63931.
GeneCards	GC01M174979.
HGNC	HGNC:14049. MRPS14.
HPA	HPA051087.
MIM	611978. gene.
neXtProt	NX_O60783.
PharmGKB	PA30998.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0199.
HOGENOM	HOG000039866.
HOVERGEN	HBG050074.
InParanoid	O60783.
KO	K02954.
OMA	FGLCRNQ.
OrthoDB	EOG444KMQ.
PhylomeDB	O60783.
Gene expression databases
ArrayExpress	O60783.
Bgee	O60783.
CleanEx	HS_MRPS14.
Genevestigator	O60783.
GermOnline	ENSG00000120333. Homo sapiens.
Family and domain databases
InterPro	IPR001209. Ribosomal_S14. [Graphical view]
PANTHER	PTHR19836. PTHR19836. 1 hit.
Pfam	PF00253. Ribosomal_S14. 1 hit. [Graphical view]
PROSITE	PS00527. RIBOSOMAL_S14. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	63931.
NextBio	65682.
SOURCE	Search...

Entry information

Entry name

RT14_HUMAN

Accession

Primary (citable) accession number: O60783
Secondary accession number(s): Q5R358

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	August 1, 1998
Last modified:	May 1, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.