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O60783

- RT14_HUMAN

UniProt

O60783 - RT14_HUMAN

Protein

28S ribosomal protein S14, mitochondrial

Gene

MRPS14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. translation Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    28S ribosomal protein S14, mitochondrial
    Short name:
    MRP-S14
    Short name:
    S14mt
    Gene namesi
    Name:MRPS14Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:14049. MRPS14.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial ribosome Source: UniProtKB
    2. mitochondrion Source: HPA
    3. nuclear membrane Source: HPA

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30998.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12812828S ribosomal protein S14, mitochondrialPRO_0000131013Add
    BLAST

    Proteomic databases

    MaxQBiO60783.
    PaxDbiO60783.
    PeptideAtlasiO60783.
    PRIDEiO60783.

    Expressioni

    Gene expression databases

    ArrayExpressiO60783.
    BgeeiO60783.
    CleanExiHS_MRPS14.
    GenevestigatoriO60783.

    Organism-specific databases

    HPAiHPA051087.

    Interactioni

    Subunit structurei

    Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DDX56Q9NY931EBI-1045956,EBI-372376

    Protein-protein interaction databases

    BioGridi121999. 16 interactions.
    IntActiO60783. 5 interactions.
    STRINGi9606.ENSP00000420714.

    Structurei

    3D structure databases

    ProteinModelPortaliO60783.
    SMRiO60783. Positions 36-128.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S14P family.Curated

    Phylogenomic databases

    eggNOGiCOG0199.
    HOGENOMiHOG000039866.
    HOVERGENiHBG050074.
    InParanoidiO60783.
    KOiK02954.
    OMAiGHEAVAN.
    OrthoDBiEOG7DVDDJ.
    PhylomeDBiO60783.
    TreeFamiTF320418.

    Family and domain databases

    InterProiIPR001209. Ribosomal_S14.
    [Graphical view]
    PANTHERiPTHR19836. PTHR19836. 1 hit.
    PfamiPF00253. Ribosomal_S14. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O60783-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAFMLGSLL RTFKQMVPSS ASGQVRSHYV DWRMWRDVKR RKMAYEYADE    50
    RLRINSLRKN TILPKILQDV ADEEIAALPR DSCPVRIRNR CVMTSRPRGV 100
    KRRWRLSRIV FRHLADHGQL SGIQRATW 128
    Length:128
    Mass (Da):15,139
    Last modified:August 1, 1998 - v1
    Checksum:iFFF3F3C70214EDE4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL049705 mRNA. Translation: CAB41269.1.
    Z99297 Genomic DNA. Translation: CAB16601.1.
    BC009788 mRNA. Translation: AAH09788.1.
    CCDSiCCDS1316.1.
    RefSeqiNP_071383.1. NM_022100.2.
    UniGeneiHs.654858.

    Genome annotation databases

    EnsembliENST00000476371; ENSP00000420714; ENSG00000120333.
    GeneIDi63931.
    KEGGihsa:63931.
    UCSCiuc001gkk.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL049705 mRNA. Translation: CAB41269.1 .
    Z99297 Genomic DNA. Translation: CAB16601.1 .
    BC009788 mRNA. Translation: AAH09788.1 .
    CCDSi CCDS1316.1.
    RefSeqi NP_071383.1. NM_022100.2.
    UniGenei Hs.654858.

    3D structure databases

    ProteinModelPortali O60783.
    SMRi O60783. Positions 36-128.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121999. 16 interactions.
    IntActi O60783. 5 interactions.
    STRINGi 9606.ENSP00000420714.

    Proteomic databases

    MaxQBi O60783.
    PaxDbi O60783.
    PeptideAtlasi O60783.
    PRIDEi O60783.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000476371 ; ENSP00000420714 ; ENSG00000120333 .
    GeneIDi 63931.
    KEGGi hsa:63931.
    UCSCi uc001gkk.3. human.

    Organism-specific databases

    CTDi 63931.
    GeneCardsi GC01M174979.
    HGNCi HGNC:14049. MRPS14.
    HPAi HPA051087.
    MIMi 611978. gene.
    neXtProti NX_O60783.
    PharmGKBi PA30998.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0199.
    HOGENOMi HOG000039866.
    HOVERGENi HBG050074.
    InParanoidi O60783.
    KOi K02954.
    OMAi GHEAVAN.
    OrthoDBi EOG7DVDDJ.
    PhylomeDBi O60783.
    TreeFami TF320418.

    Miscellaneous databases

    GenomeRNAii 63931.
    NextBioi 65682.
    PROi O60783.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60783.
    Bgeei O60783.
    CleanExi HS_MRPS14.
    Genevestigatori O60783.

    Family and domain databases

    InterProi IPR001209. Ribosomal_S14.
    [Graphical view ]
    PANTHERi PTHR19836. PTHR19836. 1 hit.
    Pfami PF00253. Ribosomal_S14. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Rhodes S.
      Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Bone marrow1 Publication.
    4. "A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins."
      Koc E.C., Burkhart W., Blackburn K., Moseley A., Koc H., Spremulli L.L.
      J. Biol. Chem. 275:32585-32591(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRT14_HUMAN
    AccessioniPrimary (citable) accession number: O60783
    Secondary accession number(s): Q5R358
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Ribosomal proteins
      Ribosomal proteins families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3