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Protein

28S ribosomal protein S14, mitochondrial

Gene

MRPS14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S14, mitochondrial
Short name:
MRP-S14
Short name:
S14mt
Alternative name(s):
Mitochondrial small ribosomal subunit protein uS14m1 Publication
Gene namesi
Name:MRPS14Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14049. MRPS14.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial ribosome Source: UniProtKB
  • mitochondrial small ribosomal subunit Source: UniProtKB

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000120333.
PharmGKBiPA30998.

Polymorphism and mutation databases

BioMutaiMRPS14.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001310131 – 12828S ribosomal protein S14, mitochondrialAdd BLAST128

Proteomic databases

EPDiO60783.
MaxQBiO60783.
PaxDbiO60783.
PeptideAtlasiO60783.
PRIDEiO60783.
TopDownProteomicsiO60783.

PTM databases

SwissPalmiO60783.

Expressioni

Gene expression databases

BgeeiENSG00000120333.
CleanExiHS_MRPS14.
ExpressionAtlasiO60783. baseline and differential.
GenevisibleiO60783. HS.

Organism-specific databases

HPAiHPA051087.

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:25838379). Interacts with LIAT1 (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi121999. 39 interactors.
IntActiO60783. 12 interactors.
STRINGi9606.ENSP00000420714.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AK1-128[»]
ProteinModelPortaliO60783.
SMRiO60783.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1741. Eukaryota.
COG0199. LUCA.
GeneTreeiENSGT00390000015663.
HOGENOMiHOG000039866.
HOVERGENiHBG050074.
InParanoidiO60783.
KOiK02954.
OMAiKRRQMAF.
OrthoDBiEOG091G10PS.
PhylomeDBiO60783.
TreeFamiTF320418.

Family and domain databases

InterProiView protein in InterPro
IPR001209. Ribosomal_S14.
PANTHERiPTHR19836. PTHR19836. 1 hit.
PfamiView protein in Pfam
PF00253. Ribosomal_S14. 1 hit.

Sequencei

Sequence statusi: Complete.

O60783-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAFMLGSLL RTFKQMVPSS ASGQVRSHYV DWRMWRDVKR RKMAYEYADE
60 70 80 90 100
RLRINSLRKN TILPKILQDV ADEEIAALPR DSCPVRIRNR CVMTSRPRGV
110 120
KRRWRLSRIV FRHLADHGQL SGIQRATW
Length:128
Mass (Da):15,139
Last modified:August 1, 1998 - v1
Checksum:iFFF3F3C70214EDE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049705 mRNA. Translation: CAB41269.1.
Z99297 Genomic DNA. Translation: CAB16601.1.
BC009788 mRNA. Translation: AAH09788.1.
CCDSiCCDS1316.1.
RefSeqiNP_071383.1. NM_022100.2.
UniGeneiHs.654858.

Genome annotation databases

EnsembliENST00000476371; ENSP00000420714; ENSG00000120333.
GeneIDi63931.
KEGGihsa:63931.
UCSCiuc001gkk.4. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRT14_HUMAN
AccessioniPrimary (citable) accession number: O60783
Secondary accession number(s): Q5R358
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: August 1, 1998
Last modified: May 10, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families