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Protein

Putative dimethylaniline monooxygenase [N-oxide-forming] 6

Gene

FMO6P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

It is probable that this protein is only produced in very small quantity or not at all as the gene coding for it seems to be unable to produce full-length transcripts.

Caution

Could be the product of a pseudogene.Curated

Catalytic activityi

N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei32FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 13FADBy similarity5
Nucleotide bindingi40 – 41FADBy similarity2
Nucleotide bindingi61 – 62FADBy similarity2
Nucleotide bindingi195 – 198NADPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandFAD, Flavoprotein, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Putative dimethylaniline monooxygenase [N-oxide-forming] 6 (EC:1.14.13.8)
Alternative name(s):
Dimethylaniline oxidase 6
Flavin-containing monooxygenase 6
Short name:
FMO 6
Gene namesi
Name:FMO6P
Synonyms:FMO6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

HGNCiHGNC:24024 FMO6P
neXtProtiNX_O60774

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei518 – 538HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi388714
PharmGKBiPA142671753

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001476691 – 539Putative dimethylaniline monooxygenase [N-oxide-forming] 6Add BLAST539

Proteomic databases

PaxDbiO60774
PeptideAtlasiO60774
PRIDEiO60774

PTM databases

iPTMnetiO60774
PhosphoSitePlusiO60774

Structurei

3D structure databases

ProteinModelPortaliO60774
SMRiO60774
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FMO family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1399 Eukaryota
COG2072 LUCA
HOGENOMiHOG000076537
HOVERGENiHBG002037
InParanoidiO60774
PhylomeDBiO60774
TreeFamiTF105285

Family and domain databases

Gene3Di3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR000960 Flavin_mOase
IPR020946 Flavin_mOase-like
IPR002255 Flavin_mOase_3
PfamiView protein in Pfam
PF00743 FMO-like, 1 hit
PIRSFiPIRSF000332 FMO, 1 hit
PRINTSiPR00370 FMOXYGENASE
PR01123 FMOXYGENASE3
SUPFAMiSSF51905 SSF51905, 2 hits

Sequencei

Sequence statusi: Complete.

O60774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKRVGIIGA GVSGLAAIWC CLEEGLEPTC FERSDDVGGL WKFSDHTEEG
60 70 80 90 100
RASIYQSVFT NSSKEMMCFP DFPYPDDYPN YIHHSKLQEY IKTYAQKKDL
110 120 130 140 150
LRYIQFETLV SGIKKCPSFL VTGQWVVVTE KDGKQESTIF DAVMICSGHH
160 170 180 190 200
VYPNLPTDSF PGLDQFRGNY LHSRDYKNPE AFKGKRVLVI GLGNSGSDIA
210 220 230 240 250
VELSRLATQV IISTRSASWV MSRVWDDGYP WDMMYVTRFA SFLRNVLPSF
260 270 280 290 300
ISDWLYVQKM NTWFKHENYG LMPLNGSLRK EPVFNDELPS RILCGTLSIK
310 320 330 340 350
PSVKEFTETS AVFEDGTMFE AIDSVIFATG YDYSYPFLDE TIMKSRNNEV
360 370 380 390 400
TLFKGIFPPL MEKPTLAVIG LVQSLGAAIP TADLQAWWAA KVFANSCTLP
410 420 430 440 450
TTNEMMDDTD EKMGKKLKCM FSSFFMFGQS QTLQTDYITY VDELGSFIGA
460 470 480 490 500
KPNIPWLFLT DPRLALEVYF GPCSPYQFRL MGPGKWDGAR NAILTQWNRT
510 520 530
VKPTRTRVVS EVQRPHPFYN LLKMLSFPLL LLAVTLTFY
Length:539
Mass (Da):61,291
Last modified:August 1, 1998 - v1
Checksum:i8E0D15CA4F79FF0C
GO

Polymorphismi

There are two alleles; one major, FMO6X105 (truncated form) and one minor, FMO6Q105, (shown here) (full-length form similar to the protein found in other mammals) (PubMed:12527699). A nonsense mutation transforms the Gln-105 into a premature stop codon (PubMed:12527699). The truncated protein is catalytically inactive (PubMed:12527699).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_015371127V → I1 PublicationCorresponds to variant dbSNP:rs61731844Ensembl.1
Natural variantiVAR_015372257V → I1 PublicationCorresponds to variant dbSNP:rs2272797Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021026 Genomic DNA No translation available.

Genome annotation databases

UCSCiuc057ngh.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFMO6_HUMAN
AccessioniPrimary (citable) accession number: O60774
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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