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Protein

Zinc finger protein 354A

Gene

ZNF354A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri214 – 23623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri242 – 26423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri464 – 48825C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri522 – 54423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri550 – 57223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri578 – 60023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 354A
Alternative name(s):
Transcription factor 17
Short name:
TCF-17
Zinc finger protein eZNF
Gene namesi
Name:ZNF354A
Synonyms:EZNF, HKL1, TCF17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:11628. ZNF354A.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: Ensembl
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36383.

Polymorphism and mutation databases

BioMutaiZNF354A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 605605Zinc finger protein 354APRO_0000047238Add
BLAST

Proteomic databases

EPDiO60765.
PaxDbiO60765.
PRIDEiO60765.

PTM databases

iPTMnetiO60765.
PhosphoSiteiO60765.

Expressioni

Tissue specificityi

Expressed in kidney and inner ear.

Gene expression databases

BgeeiO60765.
CleanExiHS_ZNF354A.
ExpressionAtlasiO60765. baseline and differential.
GenevisibleiO60765. HS.

Organism-specific databases

HPAiHPA052043.

Interactioni

Protein-protein interaction databases

BioGridi112800. 12 interactions.
STRINGi9606.ENSP00000337122.

Structurei

3D structure databases

ProteinModelPortaliO60765.
SMRiO60765. Positions 147-604.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri214 – 23623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri242 – 26423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri464 – 48825C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri522 – 54423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri550 – 57223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri578 – 60023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiO60765.
KOiK09228.
OMAiHKNTELS.
OrthoDBiEOG7KSX7Q.
PhylomeDBiO60765.
TreeFamiTF350822.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR033345. ZNF354A.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR24377:SF146. PTHR24377:SF146. 2 hits.
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60765-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGQREARP QVSLTFEDVA VLFTRDEWRK LAPSQRNLYR DVMLENYRNL
60 70 80 90 100
VSLGLPFTKP KVISLLQQGE DPWEVEKDGS GVSSLGSKSS HKTTKSTQTQ
110 120 130 140 150
DSSFQGLILK RSNRNVPWDL KLEKPYIYEG RLEKKQDKKG SFQIVSATHK
160 170 180 190 200
KIPTIERSHK NTELSQNFSP KSVLIRQQIL PREKTPPKCE IQGNSLKQNS
210 220 230 240 250
QLLNQPKITA DKRYKCSLCE KTFINTSSLR KHEKNHSGEK LFKCKECSKA
260 270 280 290 300
FSQSSALIQH QITHTGEKPY ICKECGKAFT LSTSLYKHLR THTVEKSYRC
310 320 330 340 350
KECGKSFSRR SGLFIHQKIH AEENPCKYNP GRKASSCSTS LSGCQRIHSR
360 370 380 390 400
KKSYLCNECG NTFKSSSSLR YHQRIHTGEK PFKCSECGRA FSQSASLIQH
410 420 430 440 450
ERIHTGEKPY RCNECGKGFT SISRLNRHRI IHTGEKFYNC NECGKALSSH
460 470 480 490 500
STLIIHERIH TGEKPCKCKV CGKAFRQSSA LIQHQRMHTG ERPYKCNECG
510 520 530 540 550
KTFRCNSSLS NHQRIHTGEK PYRCEECGIS FGQSSALIQH RRIHTGEKPF
560 570 580 590 600
KCNTCGKTFR QSSSRIAHQR IHTGEKPYEC NTCGKLFNHR SSLTNHYKIH

IEEDP
Length:605
Mass (Da):69,237
Last modified:October 3, 2006 - v2
Checksum:i464D20BBD9045AF9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti437 – 4371F → Y in BAA25182 (PubMed:9465904).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89928 mRNA. Translation: BAA25182.1.
AF116030 mRNA. Translation: AAD05335.1.
CCDSiCCDS4438.1.
RefSeqiNP_005640.2. NM_005649.2.
UniGeneiHs.484324.

Genome annotation databases

EnsembliENST00000335815; ENSP00000337122; ENSG00000169131.
GeneIDi6940.
KEGGihsa:6940.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89928 mRNA. Translation: BAA25182.1.
AF116030 mRNA. Translation: AAD05335.1.
CCDSiCCDS4438.1.
RefSeqiNP_005640.2. NM_005649.2.
UniGeneiHs.484324.

3D structure databases

ProteinModelPortaliO60765.
SMRiO60765. Positions 147-604.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112800. 12 interactions.
STRINGi9606.ENSP00000337122.

PTM databases

iPTMnetiO60765.
PhosphoSiteiO60765.

Polymorphism and mutation databases

BioMutaiZNF354A.

Proteomic databases

EPDiO60765.
PaxDbiO60765.
PRIDEiO60765.

Protocols and materials databases

DNASUi6940.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335815; ENSP00000337122; ENSG00000169131.
GeneIDi6940.
KEGGihsa:6940.

Organism-specific databases

CTDi6940.
GeneCardsiZNF354A.
HGNCiHGNC:11628. ZNF354A.
HPAiHPA052043.
MIMi602444. gene.
neXtProtiNX_O60765.
PharmGKBiPA36383.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiO60765.
KOiK09228.
OMAiHKNTELS.
OrthoDBiEOG7KSX7Q.
PhylomeDBiO60765.
TreeFamiTF350822.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii6940.
PROiO60765.
SOURCEiSearch...

Gene expression databases

BgeeiO60765.
CleanExiHS_ZNF354A.
ExpressionAtlasiO60765. baseline and differential.
GenevisibleiO60765. HS.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR033345. ZNF354A.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR24377:SF146. PTHR24377:SF146. 2 hits.
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning, expression and mapping of a novel human zinc-finger gene TCF17 homologous to rodent Kid1."
    Omori Y., Kyushiki H., Takeda S., Suzuki M., Kawai A., Fujiwara T., Takahashi E., Nakamura Y.
    Cytogenet. Cell Genet. 78:285-288(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. "Molecular cloning of a zinc finger gene eZNF from a human inner ear cDNA library, and in situ expression pattern of its mouse homologue in mouse inner ear."
    Jacob A.N., Manjunath N.A., Bray-Ward P., Kandpal R.P.
    Somat. Cell Mol. Genet. 24:121-129(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Inner ear.
  3. "Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1."
    Wang W., Cai J., Wu Y., Hu L., Chen Z., Hu J., Chen Z., Li W., Guo M., Huang Z.
    Cell. Mol. Life Sci. 70:3947-3958(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiZ354A_HUMAN
AccessioniPrimary (citable) accession number: O60765
Secondary accession number(s): Q9UNJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 3, 2006
Last modified: June 8, 2016
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.