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Protein

Cytohesin-interacting protein

Gene

CYTIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm.

GO - Biological processi

  • regulation of cell adhesion Source: MGI
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115165-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytohesin-interacting protein
Alternative name(s):
Cytohesin binder and regulator
Short name:
CYBR
Cytohesin-associated scaffolding protein
Short name:
CASP
Cytohesin-binding protein HE
Short name:
Cbp HE
Pleckstrin homology Sec7 and coiled-coil domains-binding protein
Gene namesi
Name:CYTIP
Synonyms:PSCDBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:9506. CYTIP.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: MGI
  • cytoplasm Source: HPA
  • early endosome Source: UniProtKB-SubCell
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi82K → E: No membrane-association. No change in the binding to CYTH1; when associated with A-90 and A-92. 1 Publication1
Mutagenesisi90F → A: No membrane-association. No change in the binding to CYTH1; when associated with E-82 and A-92. 1 Publication1
Mutagenesisi92I → A: No membrane-association. No change in the binding to CYTH1; when associated with E-82 and A-90. 1 Publication1

Organism-specific databases

DisGeNETi9595.
OpenTargetsiENSG00000115165.
PharmGKBiPA164718652.

Polymorphism and mutation databases

BioMutaiCYTIP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000970611 – 359Cytohesin-interacting proteinAdd BLAST359

Proteomic databases

MaxQBiO60759.
PaxDbiO60759.
PeptideAtlasiO60759.
PRIDEiO60759.

PTM databases

iPTMnetiO60759.
PhosphoSitePlusiO60759.

Expressioni

Tissue specificityi

Expressed in lymph nodes, thymus, spleen, lung, peripheral blood leukocytes and bone marrow.2 Publications

Inductioni

By TNF and bacterial lipopolysaccharides (LPS).1 Publication

Gene expression databases

BgeeiENSG00000115165.
CleanExiHS_CYTIP.
ExpressionAtlasiO60759. baseline and differential.
GenevisibleiO60759. HS.

Organism-specific databases

HPAiHPA007191.

Interactioni

Subunit structurei

Interacts with CYTH1 and SNX27.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CYTH1Q154382EBI-997814,EBI-997830

Protein-protein interaction databases

BioGridi114961. 8 interactors.
IntActiO60759. 4 interactors.
MINTiMINT-6176803.
STRINGi9606.ENSP00000264192.

Structurei

Secondary structure

1359
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi77 – 81Combined sources5
Beta strandi89 – 94Combined sources6
Beta strandi101 – 103Combined sources3
Beta strandi109 – 114Combined sources6
Helixi119 – 123Combined sources5
Helixi144 – 153Combined sources10
Turni154 – 156Combined sources3
Beta strandi157 – 161Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Z17X-ray2.70A67-163[»]
ProteinModelPortaliO60759.
SMRiO60759.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60759.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 166PDZPROSITE-ProRule annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni166 – 188Interaction with CYTH1Add BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili166 – 188Sequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi241 – 323Ser-richAdd BLAST83

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410ITA8. Eukaryota.
ENOG4111KMM. LUCA.
GeneTreeiENSGT00530000063734.
HOGENOMiHOG000231871.
HOVERGENiHBG053061.
InParanoidiO60759.
OMAiEGFTHKQ.
OrthoDBiEOG091G0NRM.
PhylomeDBiO60759.
TreeFamiTF316315.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60759-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLQRLLQHS SNGNLADFCA GPAYSSYSTL TGSLTMDDNR RIQMLADTVA
60 70 80 90 100
TLPRGRKQLA LTRSSSLSDF SWSQRKLVTV EKQDNETFGF EIQSYRPQNQ
110 120 130 140 150
NACSSEMFTL ICKIQEDSPA HCAGLQAGDV LANINGVSTE GFTYKQVVDL
160 170 180 190 200
IRSSGNLLTI ETLNGTMILK RTELEAKLQV LKQTLKQKWV EYRSLQLQEH
210 220 230 240 250
RLLHGDAANC PSLENMDLDE LSLFGPLPGP GPALVDRNRL SSESSCKSWL
260 270 280 290 300
SSMTMDSEDG YQTCVSEDSS RGAFSRQTST DDECFIPKEG DDFLRRSSSR
310 320 330 340 350
RNRSISNTSS GSMSPLWEGN LSSMFGTLPR KSRKGSVRKQ LLKFIPGLHR

AVEEEESRF
Length:359
Mass (Da):40,010
Last modified:September 27, 2005 - v2
Checksum:i76F0E0ED02EDD8C2
GO
Isoform 2 (identifier: O60759-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.

Note: No experimental confirmation available.
Show »
Length:253
Mass (Da):28,172
Checksum:iCE3E6B4FB0C6FA26
GO

Sequence cautioni

The sequence AAA16575 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti278T → Q in AAA16575 (PubMed:8241278).Curated1
Sequence conflicti339 – 341KQL → RVA in AAA16575 (PubMed:8241278).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02353437D → N.1 PublicationCorresponds to variant rs1042038dbSNPEnsembl.1
Natural variantiVAR_05128783Q → E.Corresponds to variant rs2229345dbSNPEnsembl.1
Natural variantiVAR_064706329P → S Found in a renal cell carcinoma case; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0555021 – 106Missing in isoform 2. 1 PublicationAdd BLAST106

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068836 mRNA. Translation: AAC19129.1.
AK301544 mRNA. Translation: BAG63041.1.
AC019201 Genomic DNA. Translation: AAY14898.1.
BC036449 mRNA. Translation: AAH36449.1.
L06633 mRNA. Translation: AAA16575.1. Different initiation.
CCDSiCCDS2204.1. [O60759-1]
PIRiS43424.
RefSeqiNP_004279.3. NM_004288.4. [O60759-1]
XP_016860875.1. XM_017005386.1. [O60759-2]
UniGeneiHs.270.

Genome annotation databases

EnsembliENST00000264192; ENSP00000264192; ENSG00000115165. [O60759-1]
GeneIDi9595.
KEGGihsa:9595.
UCSCiuc002tzj.2. human. [O60759-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068836 mRNA. Translation: AAC19129.1.
AK301544 mRNA. Translation: BAG63041.1.
AC019201 Genomic DNA. Translation: AAY14898.1.
BC036449 mRNA. Translation: AAH36449.1.
L06633 mRNA. Translation: AAA16575.1. Different initiation.
CCDSiCCDS2204.1. [O60759-1]
PIRiS43424.
RefSeqiNP_004279.3. NM_004288.4. [O60759-1]
XP_016860875.1. XM_017005386.1. [O60759-2]
UniGeneiHs.270.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Z17X-ray2.70A67-163[»]
ProteinModelPortaliO60759.
SMRiO60759.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114961. 8 interactors.
IntActiO60759. 4 interactors.
MINTiMINT-6176803.
STRINGi9606.ENSP00000264192.

PTM databases

iPTMnetiO60759.
PhosphoSitePlusiO60759.

Polymorphism and mutation databases

BioMutaiCYTIP.

Proteomic databases

MaxQBiO60759.
PaxDbiO60759.
PeptideAtlasiO60759.
PRIDEiO60759.

Protocols and materials databases

DNASUi9595.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264192; ENSP00000264192; ENSG00000115165. [O60759-1]
GeneIDi9595.
KEGGihsa:9595.
UCSCiuc002tzj.2. human. [O60759-1]

Organism-specific databases

CTDi9595.
DisGeNETi9595.
GeneCardsiCYTIP.
HGNCiHGNC:9506. CYTIP.
HPAiHPA007191.
MIMi604448. gene.
neXtProtiNX_O60759.
OpenTargetsiENSG00000115165.
PharmGKBiPA164718652.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITA8. Eukaryota.
ENOG4111KMM. LUCA.
GeneTreeiENSGT00530000063734.
HOGENOMiHOG000231871.
HOVERGENiHBG053061.
InParanoidiO60759.
OMAiEGFTHKQ.
OrthoDBiEOG091G0NRM.
PhylomeDBiO60759.
TreeFamiTF316315.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115165-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO60759.
GeneWikiiPSCDBP.
GenomeRNAii9595.
PROiO60759.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115165.
CleanExiHS_CYTIP.
ExpressionAtlasiO60759. baseline and differential.
GenevisibleiO60759. HS.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYTIP_HUMAN
AccessioniPrimary (citable) accession number: O60759
Secondary accession number(s): B4DWH9, Q15630, Q8NE32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: September 27, 2005
Last modified: November 2, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.