ID   GALR3_HUMAN             Reviewed;         368 AA.
AC   O60755; Q53YJ4;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   24-JAN-2024, entry version 179.
DE   RecName: Full=Galanin receptor type 3;
DE            Short=GAL3-R;
DE            Short=GALR-3;
GN   Name=GALR3; Synonyms=GALNR3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX   PubMed=9722565; DOI=10.1074/jbc.273.36.23321;
RA   Smith K.E., Walker M.W., Artymyshyn R., Bard J., Borowsky B., Tamm J.A.,
RA   Yao W.-J., Vaysse P.J.-J., Branchek T.A., Gerald C., Jones K.A.;
RT   "Cloned human and rat galanin GALR3 receptors: pharmacology and activation
RT   of G-protein inwardly rectifying K+ channels.";
RL   J. Biol. Chem. 273:23321-23326(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Uterus;
RA   Bennett M.M., Lescoe M.K., Gallipoli P.Z., Ramabhadran T.V.;
RT   "Homologue of the human galanin 2 receptor gene isolated from a human
RT   uterus cDNA library.";
RL   Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=9832121; DOI=10.1046/j.1471-4159.1998.71062239.x;
RA   Kolakowski L.F. Jr., O'Neill G.P., Howard A.D., Broussard S.R.,
RA   Sullivan K.A., Feighner S.D., Sawzdargo M., Nguyen T., Kargman S.,
RA   Shiao L.-L., Hreniuk D.L., Tan C.P., Evans J., Abramovitz M.,
RA   Chateauneuf A., Coulombe N., Ng G., Johnson M.P., Tharian A.,
RA   Khoshbouei H., George S.R., Smith R.G., O'Dowd B.F.;
RT   "Molecular characterization and expression of cloned human galanin
RT   receptors GALR2 and GALR3.";
RL   J. Neurochem. 71:2239-2251(1998).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9928159; DOI=10.1111/j.1749-6632.1998.tb10683.x;
RA   Iismaa T.P., Fathi Z., Hort Y.J., Iben L.G., Dutton J.L., Baker E.,
RA   Sutherland G.R., Shine J.;
RT   "Structural organization and chromosomal localization of three human
RT   galanin receptor genes.";
RL   Ann. N. Y. Acad. Sci. 863:56-63(1998).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Retina;
RA   Eutsler E.P., Kopatz S.A., Sharma S.V.;
RT   "Isolation of cDNA coding for galanin receptor 3 (GALR3).";
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10591208; DOI=10.1038/990031;
RA   Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA   Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA   Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA   Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA   Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA   Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA   Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA   Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA   Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA   Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA   Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA   Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA   Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA   Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA   Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA   Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA   Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA   Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA   Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA   Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA   Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA   Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA   Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA   Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA   Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA   Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA   Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA   Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA   Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA   Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA   Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA   Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA   Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA   McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA   Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA   Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA   Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA   Wright H.;
RT   "The DNA sequence of human chromosome 22.";
RL   Nature 402:489-495(1999).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [9]
RP   FUNCTION AS A RECEPTOR FOR SPEXIN-1.
RX   PubMed=24517231; DOI=10.1210/en.2013-2106;
RA   Kim D.K., Yun S., Son G.H., Hwang J.I., Park C.R., Kim J.I., Kim K.,
RA   Vaudry H., Seong J.Y.;
RT   "Coevolution of the spexin/galanin/kisspeptin family: Spexin activates
RT   galanin receptor type II and III.";
RL   Endocrinology 155:1864-1873(2014).
RN   [10]
RP   FUNCTION.
RX   PubMed=25691535; DOI=10.1093/hmg/ddv060;
RA   Guipponi M., Chentouf A., Webling K.E., Freimann K., Crespel A., Nobile C.,
RA   Lemke J.R., Hansen J., Dorn T., Lesca G., Ryvlin P., Hirsch E., Rudolf G.,
RA   Rosenberg D.S., Weber Y., Becker F., Helbig I., Muhle H., Salzmann A.,
RA   Chaouch M., Oubaiche M.L., Ziglio S., Gehrig C., Santoni F., Pizzato M.,
RA   Langel U., Antonarakis S.E.;
RT   "Galanin pathogenic mutations in temporal lobe epilepsy.";
RL   Hum. Mol. Genet. 24:3082-3091(2015).
CC   -!- FUNCTION: Receptor for the hormone galanin (PubMed:25691535). Receptor
CC       for the hormone spexin-1 (PubMed:24517231).
CC       {ECO:0000269|PubMed:24517231, ECO:0000269|PubMed:25691535,
CC       ECO:0000269|PubMed:9722565, ECO:0000269|PubMed:9832121}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF073799; AAC35944.1; -; mRNA.
DR   EMBL; AF067733; AAC18860.1; -; mRNA.
DR   EMBL; AF129514; AAD47348.2; -; Genomic_DNA.
DR   EMBL; AF129513; AAD47348.2; JOINED; Genomic_DNA.
DR   EMBL; AY587582; AAS98215.1; -; mRNA.
DR   EMBL; AB065934; BAC06149.1; -; Genomic_DNA.
DR   EMBL; Z97630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471095; EAW60191.1; -; Genomic_DNA.
DR   CCDS; CCDS13958.1; -.
DR   RefSeq; NP_003605.1; NM_003614.1.
DR   AlphaFoldDB; O60755; -.
DR   SMR; O60755; -.
DR   BioGRID; 114058; 30.
DR   STRING; 9606.ENSP00000249041; -.
DR   BindingDB; O60755; -.
DR   ChEMBL; CHEMBL2731; -.
DR   GuidetoPHARMACOLOGY; 245; -.
DR   GlyCosmos; O60755; 1 site, No reported glycans.
DR   GlyGen; O60755; 1 site.
DR   iPTMnet; O60755; -.
DR   PhosphoSitePlus; O60755; -.
DR   BioMuta; GALR3; -.
DR   MassIVE; O60755; -.
DR   PaxDb; 9606-ENSP00000249041; -.
DR   Antibodypedia; 12147; 258 antibodies from 33 providers.
DR   DNASU; 8484; -.
DR   Ensembl; ENST00000249041.3; ENSP00000249041.2; ENSG00000128310.3.
DR   GeneID; 8484; -.
DR   KEGG; hsa:8484; -.
DR   MANE-Select; ENST00000249041.3; ENSP00000249041.2; NM_003614.2; NP_003605.1.
DR   UCSC; uc003aub.1; human.
DR   AGR; HGNC:4134; -.
DR   CTD; 8484; -.
DR   DisGeNET; 8484; -.
DR   GeneCards; GALR3; -.
DR   HGNC; HGNC:4134; GALR3.
DR   HPA; ENSG00000128310; Not detected.
DR   MIM; 603692; gene.
DR   neXtProt; NX_O60755; -.
DR   OpenTargets; ENSG00000128310; -.
DR   PharmGKB; PA28547; -.
DR   VEuPathDB; HostDB:ENSG00000128310; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT01050000244841; -.
DR   HOGENOM; CLU_009579_6_4_1; -.
DR   InParanoid; O60755; -.
DR   OMA; YQIVHYH; -.
DR   OrthoDB; 2915794at2759; -.
DR   PhylomeDB; O60755; -.
DR   TreeFam; TF315737; -.
DR   PathwayCommons; O60755; -.
DR   Reactome; R-HSA-375276; Peptide ligand-binding receptors.
DR   Reactome; R-HSA-418594; G alpha (i) signalling events.
DR   SignaLink; O60755; -.
DR   SIGNOR; O60755; -.
DR   BioGRID-ORCS; 8484; 18 hits in 1140 CRISPR screens.
DR   ChiTaRS; GALR3; human.
DR   GeneWiki; Galanin_receptor_3; -.
DR   GenomeRNAi; 8484; -.
DR   Pharos; O60755; Tchem.
DR   PRO; PR:O60755; -.
DR   Proteomes; UP000005640; Chromosome 22.
DR   RNAct; O60755; Protein.
DR   Bgee; ENSG00000128310; Expressed in cerebellar hemisphere and 20 other cell types or tissues.
DR   GO; GO:0005929; C:cilium; IDA:MGI.
DR   GO; GO:0016020; C:membrane; TAS:ProtInc.
DR   GO; GO:0097730; C:non-motile cilium; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0004966; F:galanin receptor activity; IDA:UniProtKB.
DR   GO; GO:0017046; F:peptide hormone binding; IDA:UniProtKB.
DR   GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007268; P:chemical synaptic transmission; TAS:ProtInc.
DR   GO; GO:0007631; P:feeding behavior; TAS:ProtInc.
DR   GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IDA:GO_Central.
DR   GO; GO:0090663; P:galanin-activated signaling pathway; IDA:GO_Central.
DR   GO; GO:0007611; P:learning or memory; TAS:ProtInc.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR   CDD; cd15097; 7tmA_Gal2_Gal3_R; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000405; Galanin_rcpt.
DR   InterPro; IPR003908; Galnin_3_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR24230; G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR24230:SF17; GALANIN RECEPTOR TYPE 3; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR01420; GALANIN3R.
DR   PRINTS; PR00663; GALANINR.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; O60755; HS.
PE   1: Evidence at protein level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..368
FT                   /note="Galanin receptor type 3"
FT                   /id="PRO_0000069469"
FT   TOPO_DOM        1..20
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        21..41
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        42..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        79..96
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..118
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..138
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        160..184
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        206..236
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        258..259
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        281..368
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          317..368
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           308
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        6
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        95..172
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         342
FT                   /note="R -> G (in dbSNP:rs8137541)"
FT                   /id="VAR_049387"
FT   VARIANT         349
FT                   /note="Q -> R (in dbSNP:rs8137553)"
FT                   /id="VAR_059322"
SQ   SEQUENCE   368 AA;  39573 MW;  E8F46B66422C3150 CRC64;
     MADAQNISLD SPGSVGAVAV PVVFALIFLL GTVGNGLVLA VLLQPGPSAW QEPGSTTDLF
     ILNLAVADLC FILCCVPFQA TIYTLDAWLF GALVCKAVHL LIYLTMYASS FTLAAVSVDR
     YLAVRHPLRS RALRTPRNAR AAVGLVWLLA ALFSAPYLSY YGTVRYGALE LCVPAWEDAR
     RRALDVATFA AGYLLPVAVV SLAYGRTLRF LWAAVGPAGA AAAEARRRAT GRAGRAMLAV
     AALYALCWGP HHALILCFWY GRFAFSPATY ACRLASHCLA YANSCLNPLV YALASRHFRA
     RFRRLWPCGR RRRHRARRAL RRVRPASSGP PGCPGDARPS GRLLAGGGQG PEPREGPVHG
     GEAARGPE
//