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O60755

- GALR3_HUMAN

UniProt

O60755 - GALR3_HUMAN

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Protein

Galanin receptor type 3

Gene
GALR3, GALNR3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for the hormone galanin. Receptor for the hormone spexin-1 (1 Publication).

GO - Molecular functioni

  1. galanin receptor activity Source: ProtInc

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Ensembl
  2. feeding behavior Source: ProtInc
  3. learning or memory Source: ProtInc
  4. negative regulation of adenylate cyclase activity Source: ProtInc
  5. neuropeptide signaling pathway Source: ProtInc
  6. synaptic transmission Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin receptor type 3
Short name:
GAL3-R
Short name:
GALR-3
Gene namesi
Name:GALR3
Synonyms:GALNR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:4134. GALR3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020Extracellular Reviewed predictionAdd
BLAST
Transmembranei21 – 4121Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini42 – 5716Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei58 – 7821Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini79 – 9618Extracellular Reviewed predictionAdd
BLAST
Transmembranei97 – 11822Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini119 – 13820Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei139 – 15921Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini160 – 18425Extracellular Reviewed predictionAdd
BLAST
Transmembranei185 – 20521Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini206 – 23631Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei237 – 25721Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini258 – 2592Extracellular Reviewed prediction
Transmembranei260 – 28021Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini281 – 36888Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28547.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368Galanin receptor type 3PRO_0000069469Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi95 ↔ 172 By similarity
Lipidationi308 – 3081S-palmitoyl cysteine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO60755.
PRIDEiO60755.

PTM databases

PhosphoSiteiO60755.

Expressioni

Gene expression databases

BgeeiO60755.
CleanExiHS_GALR3.
GenevestigatoriO60755.

Interactioni

Protein-protein interaction databases

BioGridi114058. 1 interaction.
STRINGi9606.ENSP00000249041.

Structurei

3D structure databases

ProteinModelPortaliO60755.
SMRiO60755. Positions 18-305.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi218 – 2258Poly-Ala
Compositional biasi310 – 3189Poly-Arg

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320953.
HOGENOMiHOG000230487.
HOVERGENiHBG101447.
InParanoidiO60755.
KOiK04232.
OMAiLWPCGRR.
OrthoDBiEOG7327PK.
PhylomeDBiO60755.
TreeFamiTF315737.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000405. Galanin_rcpt.
IPR003908. Galnin_3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01420. GALANIN3R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60755-1 [UniParc]FASTAAdd to Basket

« Hide

MADAQNISLD SPGSVGAVAV PVVFALIFLL GTVGNGLVLA VLLQPGPSAW    50
QEPGSTTDLF ILNLAVADLC FILCCVPFQA TIYTLDAWLF GALVCKAVHL 100
LIYLTMYASS FTLAAVSVDR YLAVRHPLRS RALRTPRNAR AAVGLVWLLA 150
ALFSAPYLSY YGTVRYGALE LCVPAWEDAR RRALDVATFA AGYLLPVAVV 200
SLAYGRTLRF LWAAVGPAGA AAAEARRRAT GRAGRAMLAV AALYALCWGP 250
HHALILCFWY GRFAFSPATY ACRLASHCLA YANSCLNPLV YALASRHFRA 300
RFRRLWPCGR RRRHRARRAL RRVRPASSGP PGCPGDARPS GRLLAGGGQG 350
PEPREGPVHG GEAARGPE 368
Length:368
Mass (Da):39,573
Last modified:August 1, 1998 - v1
Checksum:iE8F46B66422C3150
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti342 – 3421R → G.
Corresponds to variant rs8137541 [ dbSNP | Ensembl ].
VAR_049387
Natural varianti349 – 3491Q → R.
Corresponds to variant rs8137553 [ dbSNP | Ensembl ].
VAR_059322

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF073799 mRNA. Translation: AAC35944.1.
AF067733 mRNA. Translation: AAC18860.1.
AF129514, AF129513 Genomic DNA. Translation: AAD47348.2.
AY587582 mRNA. Translation: AAS98215.1.
AB065934 Genomic DNA. Translation: BAC06149.1.
Z97630 Genomic DNA. Translation: CAB42831.1.
CH471095 Genomic DNA. Translation: EAW60191.1.
CCDSiCCDS13958.1.
RefSeqiNP_003605.1. NM_003614.1.
UniGeneiHs.158353.

Genome annotation databases

EnsembliENST00000249041; ENSP00000249041; ENSG00000128310.
GeneIDi8484.
KEGGihsa:8484.
UCSCiuc003aub.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF073799 mRNA. Translation: AAC35944.1 .
AF067733 mRNA. Translation: AAC18860.1 .
AF129514 , AF129513 Genomic DNA. Translation: AAD47348.2 .
AY587582 mRNA. Translation: AAS98215.1 .
AB065934 Genomic DNA. Translation: BAC06149.1 .
Z97630 Genomic DNA. Translation: CAB42831.1 .
CH471095 Genomic DNA. Translation: EAW60191.1 .
CCDSi CCDS13958.1.
RefSeqi NP_003605.1. NM_003614.1.
UniGenei Hs.158353.

3D structure databases

ProteinModelPortali O60755.
SMRi O60755. Positions 18-305.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114058. 1 interaction.
STRINGi 9606.ENSP00000249041.

Chemistry

BindingDBi O60755.
ChEMBLi CHEMBL2731.
GuidetoPHARMACOLOGYi 245.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O60755.

Proteomic databases

PaxDbi O60755.
PRIDEi O60755.

Protocols and materials databases

DNASUi 8484.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000249041 ; ENSP00000249041 ; ENSG00000128310 .
GeneIDi 8484.
KEGGi hsa:8484.
UCSCi uc003aub.1. human.

Organism-specific databases

CTDi 8484.
GeneCardsi GC22P038219.
HGNCi HGNC:4134. GALR3.
MIMi 603692. gene.
neXtProti NX_O60755.
PharmGKBi PA28547.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG320953.
HOGENOMi HOG000230487.
HOVERGENi HBG101447.
InParanoidi O60755.
KOi K04232.
OMAi LWPCGRR.
OrthoDBi EOG7327PK.
PhylomeDBi O60755.
TreeFami TF315737.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii Galanin_receptor_3.
GenomeRNAii 8484.
NextBioi 31747.
PROi O60755.
SOURCEi Search...

Gene expression databases

Bgeei O60755.
CleanExi HS_GALR3.
Genevestigatori O60755.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000405. Galanin_rcpt.
IPR003908. Galnin_3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01420. GALANIN3R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloned human and rat galanin GALR3 receptors: pharmacology and activation of G-protein inwardly rectifying K+ channels."
    Smith K.E., Walker M.W., Artymyshyn R., Bard J., Borowsky B., Tamm J.A., Yao W.-J., Vaysse P.J.-J., Branchek T.A., Gerald C., Jones K.A.
    J. Biol. Chem. 273:23321-23326(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Homologue of the human galanin 2 receptor gene isolated from a human uterus cDNA library."
    Bennett M.M., Lescoe M.K., Gallipoli P.Z., Ramabhadran T.V.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Uterus.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Structural organization and chromosomal localization of three human galanin receptor genes."
    Iismaa T.P., Fathi Z., Hort Y.J., Iben L.G., Dutton J.L., Baker E., Sutherland G.R., Shine J.
    Ann. N. Y. Acad. Sci. 863:56-63(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Isolation of cDNA coding for galanin receptor 3 (GALR3)."
    Eutsler E.P., Kopatz S.A., Sharma S.V.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  6. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III."
    Kim D.K., Yun S., Son G.H., Hwang J.I., Park C.R., Kim J.I., Kim K., Vaudry H., Seong J.Y.
    Endocrinology 155:1864-1873(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A RECEPTOR FOR SPEXIN-1.

Entry informationi

Entry nameiGALR3_HUMAN
AccessioniPrimary (citable) accession number: O60755
Secondary accession number(s): Q53YJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: September 3, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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