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O60755 (GALR3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Galanin receptor type 3

Short name=GAL3-R
Short name=GALR-3
Gene names
Name:GALR3
Synonyms:GALNR3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the hormone galanin.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 368368Galanin receptor type 3
PRO_0000069469

Regions

Topological domain1 – 2020Extracellular Potential
Transmembrane21 – 4121Helical; Name=1; Potential
Topological domain42 – 5716Cytoplasmic Potential
Transmembrane58 – 7821Helical; Name=2; Potential
Topological domain79 – 9618Extracellular Potential
Transmembrane97 – 11822Helical; Name=3; Potential
Topological domain119 – 13820Cytoplasmic Potential
Transmembrane139 – 15921Helical; Name=4; Potential
Topological domain160 – 18425Extracellular Potential
Transmembrane185 – 20521Helical; Name=5; Potential
Topological domain206 – 23631Cytoplasmic Potential
Transmembrane237 – 25721Helical; Name=6; Potential
Topological domain258 – 2592Extracellular Potential
Transmembrane260 – 28021Helical; Name=7; Potential
Topological domain281 – 36888Cytoplasmic Potential
Compositional bias218 – 2258Poly-Ala
Compositional bias310 – 3189Poly-Arg

Amino acid modifications

Lipidation3081S-palmitoyl cysteine By similarity
Glycosylation61N-linked (GlcNAc...) Potential
Disulfide bond95 ↔ 172 By similarity

Natural variations

Natural variant3421R → G.
Corresponds to variant rs8137541 [ dbSNP | Ensembl ].
VAR_049387
Natural variant3491Q → R.
Corresponds to variant rs8137553 [ dbSNP | Ensembl ].
VAR_059322

Sequences

Sequence LengthMass (Da)Tools
O60755 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: E8F46B66422C3150

FASTA36839,573
        10         20         30         40         50         60 
MADAQNISLD SPGSVGAVAV PVVFALIFLL GTVGNGLVLA VLLQPGPSAW QEPGSTTDLF 

        70         80         90        100        110        120 
ILNLAVADLC FILCCVPFQA TIYTLDAWLF GALVCKAVHL LIYLTMYASS FTLAAVSVDR 

       130        140        150        160        170        180 
YLAVRHPLRS RALRTPRNAR AAVGLVWLLA ALFSAPYLSY YGTVRYGALE LCVPAWEDAR 

       190        200        210        220        230        240 
RRALDVATFA AGYLLPVAVV SLAYGRTLRF LWAAVGPAGA AAAEARRRAT GRAGRAMLAV 

       250        260        270        280        290        300 
AALYALCWGP HHALILCFWY GRFAFSPATY ACRLASHCLA YANSCLNPLV YALASRHFRA 

       310        320        330        340        350        360 
RFRRLWPCGR RRRHRARRAL RRVRPASSGP PGCPGDARPS GRLLAGGGQG PEPREGPVHG 


GEAARGPE 

« Hide

References

« Hide 'large scale' references
[1]"Cloned human and rat galanin GALR3 receptors: pharmacology and activation of G-protein inwardly rectifying K+ channels."
Smith K.E., Walker M.W., Artymyshyn R., Bard J., Borowsky B., Tamm J.A., Yao W.-J., Vaysse P.J.-J., Branchek T.A., Gerald C., Jones K.A.
J. Biol. Chem. 273:23321-23326(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Homologue of the human galanin 2 receptor gene isolated from a human uterus cDNA library."
Bennett M.M., Lescoe M.K., Gallipoli P.Z., Ramabhadran T.V.
Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Uterus.
[3]"Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3."
Kolakowski L.F. Jr., O'Neill G.P., Howard A.D., Broussard S.R., Sullivan K.A., Feighner S.D., Sawzdargo M., Nguyen T., Kargman S., Shiao L.-L., Hreniuk D.L., Tan C.P., Evans J., Abramovitz M., Chateauneuf A., Coulombe N., Ng G., Johnson M.P. expand/collapse author list , Tharian A., Khoshbouei H., George S.R., Smith R.G., O'Dowd B.F.
J. Neurochem. 71:2239-2251(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Structural organization and chromosomal localization of three human galanin receptor genes."
Iismaa T.P., Fathi Z., Hort Y.J., Iben L.G., Dutton J.L., Baker E., Sutherland G.R., Shine J.
Ann. N. Y. Acad. Sci. 863:56-63(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Isolation of cDNA coding for galanin receptor 3 (GALR3)."
Eutsler E.P., Kopatz S.A., Sharma S.V.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Retina.
[6]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF073799 mRNA. Translation: AAC35944.1.
AF067733 mRNA. Translation: AAC18860.1.
AF129514, AF129513 Genomic DNA. Translation: AAD47348.2.
AY587582 mRNA. Translation: AAS98215.1.
AB065934 Genomic DNA. Translation: BAC06149.1.
Z97630 Genomic DNA. Translation: CAB42831.1.
CH471095 Genomic DNA. Translation: EAW60191.1.
RefSeqNP_003605.1. NM_003614.1.
UniGeneHs.158353.

3D structure databases

ProteinModelPortalO60755.
SMRO60755. Positions 18-309.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114058. 1 interaction.
STRING9606.ENSP00000249041.

Chemistry

BindingDBO60755.
ChEMBLCHEMBL2731.
GuidetoPHARMACOLOGY245.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteO60755.

Proteomic databases

PaxDbO60755.
PRIDEO60755.

Protocols and materials databases

DNASU8484.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000249041; ENSP00000249041; ENSG00000128310.
GeneID8484.
KEGGhsa:8484.
UCSCuc003aub.1. human.

Organism-specific databases

CTD8484.
GeneCardsGC22P038219.
HGNCHGNC:4134. GALR3.
MIM603692. gene.
neXtProtNX_O60755.
PharmGKBPA28547.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG320953.
HOGENOMHOG000230487.
HOVERGENHBG101447.
InParanoidO60755.
KOK04232.
OMALWPCGRR.
OrthoDBEOG7327PK.
PhylomeDBO60755.
TreeFamTF315737.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeO60755.
CleanExHS_GALR3.
GenevestigatorO60755.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000405. Galanin_rcpt.
IPR003908. Galnin_3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01420. GALANIN3R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGalanin_receptor_3.
GenomeRNAi8484.
NextBio31747.
PROO60755.
SOURCESearch...

Entry information

Entry nameGALR3_HUMAN
AccessionPrimary (citable) accession number: O60755
Secondary accession number(s): Q53YJ4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: April 16, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries