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Protein

Galanin receptor type 3

Gene

GALR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the hormone galanin (PubMed:25691535). Receptor for the hormone spexin-1 (PubMed:24517231).4 Publications

GO - Molecular functioni

  • galanin receptor activity Source: UniProtKB
  • peptide hormone binding Source: UniProtKB

GO - Biological processi

  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: GO_Central
  • chemical synaptic transmission Source: ProtInc
  • feeding behavior Source: ProtInc
  • galanin-activated signaling pathway Source: GO_Central
  • G-protein coupled receptor signaling pathway Source: Reactome
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
  • learning or memory Source: ProtInc
  • negative regulation of adenylate cyclase activity Source: InterPro
  • neuropeptide signaling pathway Source: ProtInc
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin receptor type 3
Short name:
GAL3-R
Short name:
GALR-3
Gene namesi
Name:GALR3
Synonyms:GALNR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000128310.2
HGNCiHGNC:4134 GALR3
MIMi603692 gene
neXtProtiNX_O60755

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20ExtracellularSequence analysisAdd BLAST20
Transmembranei21 – 41Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini42 – 57CytoplasmicSequence analysisAdd BLAST16
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini79 – 96ExtracellularSequence analysisAdd BLAST18
Transmembranei97 – 118Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini119 – 138CytoplasmicSequence analysisAdd BLAST20
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 184ExtracellularSequence analysisAdd BLAST25
Transmembranei185 – 205Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini206 – 236CytoplasmicSequence analysisAdd BLAST31
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 259ExtracellularSequence analysis2
Transmembranei260 – 280Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini281 – 368CytoplasmicSequence analysisAdd BLAST88

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8484
OpenTargetsiENSG00000128310
PharmGKBiPA28547

Chemistry databases

ChEMBLiCHEMBL2731
GuidetoPHARMACOLOGYi245

Polymorphism and mutation databases

BioMutaiGALR3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694691 – 368Galanin receptor type 3Add BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 172PROSITE-ProRule annotation
Lipidationi308S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO60755
PRIDEiO60755

PTM databases

iPTMnetiO60755
PhosphoSitePlusiO60755

Expressioni

Gene expression databases

BgeeiENSG00000128310
CleanExiHS_GALR3
GenevisibleiO60755 HS

Interactioni

Protein-protein interaction databases

BioGridi1140581 interactor.
STRINGi9606.ENSP00000249041

Chemistry databases

BindingDBiO60755

Structurei

3D structure databases

ProteinModelPortaliO60755
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi218 – 225Poly-Ala8
Compositional biasi310 – 318Poly-Arg9

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00860000133695
HOGENOMiHOG000230487
HOVERGENiHBG101447
InParanoidiO60755
KOiK04232
OMAiLWPCGRR
OrthoDBiEOG091G0ZDG
PhylomeDBiO60755
TreeFamiTF315737

Family and domain databases

InterProiView protein in InterPro
IPR000405 Galanin_rcpt
IPR003908 Galnin_3_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01420 GALANIN3R
PR00663 GALANINR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O60755-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAQNISLD SPGSVGAVAV PVVFALIFLL GTVGNGLVLA VLLQPGPSAW
60 70 80 90 100
QEPGSTTDLF ILNLAVADLC FILCCVPFQA TIYTLDAWLF GALVCKAVHL
110 120 130 140 150
LIYLTMYASS FTLAAVSVDR YLAVRHPLRS RALRTPRNAR AAVGLVWLLA
160 170 180 190 200
ALFSAPYLSY YGTVRYGALE LCVPAWEDAR RRALDVATFA AGYLLPVAVV
210 220 230 240 250
SLAYGRTLRF LWAAVGPAGA AAAEARRRAT GRAGRAMLAV AALYALCWGP
260 270 280 290 300
HHALILCFWY GRFAFSPATY ACRLASHCLA YANSCLNPLV YALASRHFRA
310 320 330 340 350
RFRRLWPCGR RRRHRARRAL RRVRPASSGP PGCPGDARPS GRLLAGGGQG
360
PEPREGPVHG GEAARGPE
Length:368
Mass (Da):39,573
Last modified:August 1, 1998 - v1
Checksum:iE8F46B66422C3150
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049387342R → G. Corresponds to variant dbSNP:rs8137541Ensembl.1
Natural variantiVAR_059322349Q → R. Corresponds to variant dbSNP:rs8137553Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073799 mRNA Translation: AAC35944.1
AF067733 mRNA Translation: AAC18860.1
AF129514, AF129513 Genomic DNA Translation: AAD47348.2
AY587582 mRNA Translation: AAS98215.1
AB065934 Genomic DNA Translation: BAC06149.1
Z97630 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60191.1
CCDSiCCDS13958.1
RefSeqiNP_003605.1, NM_003614.1
UniGeneiHs.158353

Genome annotation databases

EnsembliENST00000249041; ENSP00000249041; ENSG00000128310
GeneIDi8484
KEGGihsa:8484
UCSCiuc003aub.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGALR3_HUMAN
AccessioniPrimary (citable) accession number: O60755
Secondary accession number(s): Q53YJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome