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Protein

Galanin receptor type 3

Gene

GALR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the hormone galanin. Receptor for the hormone spexin-1 (PubMed:24517231).1 Publication

GO - Molecular functioni

  1. galanin receptor activity Source: UniProtKB
  2. peptide hormone binding Source: UniProtKB

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Ensembl
  2. feeding behavior Source: ProtInc
  3. learning or memory Source: ProtInc
  4. negative regulation of adenylate cyclase activity Source: ProtInc
  5. neuropeptide signaling pathway Source: ProtInc
  6. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  7. synaptic transmission Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin receptor type 3
Short name:
GAL3-R
Short name:
GALR-3
Gene namesi
Name:GALR3
Synonyms:GALNR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:4134. GALR3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020ExtracellularSequence AnalysisAdd
BLAST
Transmembranei21 – 4121Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini42 – 5716CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei58 – 7821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini79 – 9618ExtracellularSequence AnalysisAdd
BLAST
Transmembranei97 – 11822Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini119 – 13820CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei139 – 15921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini160 – 18425ExtracellularSequence AnalysisAdd
BLAST
Transmembranei185 – 20521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini206 – 23631CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini258 – 2592ExtracellularSequence Analysis
Transmembranei260 – 28021Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini281 – 36888CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28547.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368Galanin receptor type 3PRO_0000069469Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi95 ↔ 172PROSITE-ProRule annotation
Lipidationi308 – 3081S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO60755.
PRIDEiO60755.

PTM databases

PhosphoSiteiO60755.

Expressioni

Gene expression databases

BgeeiO60755.
CleanExiHS_GALR3.
GenevestigatoriO60755.

Interactioni

Protein-protein interaction databases

BioGridi114058. 1 interaction.
STRINGi9606.ENSP00000249041.

Structurei

3D structure databases

ProteinModelPortaliO60755.
SMRiO60755. Positions 18-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi218 – 2258Poly-Ala
Compositional biasi310 – 3189Poly-Arg

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320953.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230487.
HOVERGENiHBG101447.
InParanoidiO60755.
KOiK04232.
OMAiPGGWNAS.
OrthoDBiEOG7327PK.
PhylomeDBiO60755.
TreeFamiTF315737.

Family and domain databases

InterProiIPR000405. Galanin_rcpt.
IPR003908. Galnin_3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01420. GALANIN3R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60755-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAQNISLD SPGSVGAVAV PVVFALIFLL GTVGNGLVLA VLLQPGPSAW
60 70 80 90 100
QEPGSTTDLF ILNLAVADLC FILCCVPFQA TIYTLDAWLF GALVCKAVHL
110 120 130 140 150
LIYLTMYASS FTLAAVSVDR YLAVRHPLRS RALRTPRNAR AAVGLVWLLA
160 170 180 190 200
ALFSAPYLSY YGTVRYGALE LCVPAWEDAR RRALDVATFA AGYLLPVAVV
210 220 230 240 250
SLAYGRTLRF LWAAVGPAGA AAAEARRRAT GRAGRAMLAV AALYALCWGP
260 270 280 290 300
HHALILCFWY GRFAFSPATY ACRLASHCLA YANSCLNPLV YALASRHFRA
310 320 330 340 350
RFRRLWPCGR RRRHRARRAL RRVRPASSGP PGCPGDARPS GRLLAGGGQG
360
PEPREGPVHG GEAARGPE
Length:368
Mass (Da):39,573
Last modified:August 1, 1998 - v1
Checksum:iE8F46B66422C3150
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti342 – 3421R → G.
Corresponds to variant rs8137541 [ dbSNP | Ensembl ].
VAR_049387
Natural varianti349 – 3491Q → R.
Corresponds to variant rs8137553 [ dbSNP | Ensembl ].
VAR_059322

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073799 mRNA. Translation: AAC35944.1.
AF067733 mRNA. Translation: AAC18860.1.
AF129514, AF129513 Genomic DNA. Translation: AAD47348.2.
AY587582 mRNA. Translation: AAS98215.1.
AB065934 Genomic DNA. Translation: BAC06149.1.
Z97630 Genomic DNA. Translation: CAB42831.1.
CH471095 Genomic DNA. Translation: EAW60191.1.
CCDSiCCDS13958.1.
RefSeqiNP_003605.1. NM_003614.1.
UniGeneiHs.158353.

Genome annotation databases

EnsembliENST00000249041; ENSP00000249041; ENSG00000128310.
GeneIDi8484.
KEGGihsa:8484.
UCSCiuc003aub.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073799 mRNA. Translation: AAC35944.1.
AF067733 mRNA. Translation: AAC18860.1.
AF129514, AF129513 Genomic DNA. Translation: AAD47348.2.
AY587582 mRNA. Translation: AAS98215.1.
AB065934 Genomic DNA. Translation: BAC06149.1.
Z97630 Genomic DNA. Translation: CAB42831.1.
CH471095 Genomic DNA. Translation: EAW60191.1.
CCDSiCCDS13958.1.
RefSeqiNP_003605.1. NM_003614.1.
UniGeneiHs.158353.

3D structure databases

ProteinModelPortaliO60755.
SMRiO60755. Positions 18-305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114058. 1 interaction.
STRINGi9606.ENSP00000249041.

Chemistry

BindingDBiO60755.
ChEMBLiCHEMBL2731.
GuidetoPHARMACOLOGYi245.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiO60755.

Proteomic databases

PaxDbiO60755.
PRIDEiO60755.

Protocols and materials databases

DNASUi8484.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000249041; ENSP00000249041; ENSG00000128310.
GeneIDi8484.
KEGGihsa:8484.
UCSCiuc003aub.1. human.

Organism-specific databases

CTDi8484.
GeneCardsiGC22P038219.
HGNCiHGNC:4134. GALR3.
MIMi603692. gene.
neXtProtiNX_O60755.
PharmGKBiPA28547.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG320953.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230487.
HOVERGENiHBG101447.
InParanoidiO60755.
KOiK04232.
OMAiPGGWNAS.
OrthoDBiEOG7327PK.
PhylomeDBiO60755.
TreeFamiTF315737.

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiGalanin_receptor_3.
GenomeRNAii8484.
NextBioi31747.
PROiO60755.
SOURCEiSearch...

Gene expression databases

BgeeiO60755.
CleanExiHS_GALR3.
GenevestigatoriO60755.

Family and domain databases

InterProiIPR000405. Galanin_rcpt.
IPR003908. Galnin_3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01420. GALANIN3R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloned human and rat galanin GALR3 receptors: pharmacology and activation of G-protein inwardly rectifying K+ channels."
    Smith K.E., Walker M.W., Artymyshyn R., Bard J., Borowsky B., Tamm J.A., Yao W.-J., Vaysse P.J.-J., Branchek T.A., Gerald C., Jones K.A.
    J. Biol. Chem. 273:23321-23326(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Homologue of the human galanin 2 receptor gene isolated from a human uterus cDNA library."
    Bennett M.M., Lescoe M.K., Gallipoli P.Z., Ramabhadran T.V.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Uterus.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Structural organization and chromosomal localization of three human galanin receptor genes."
    Iismaa T.P., Fathi Z., Hort Y.J., Iben L.G., Dutton J.L., Baker E., Sutherland G.R., Shine J.
    Ann. N. Y. Acad. Sci. 863:56-63(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Isolation of cDNA coding for galanin receptor 3 (GALR3)."
    Eutsler E.P., Kopatz S.A., Sharma S.V.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  6. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III."
    Kim D.K., Yun S., Son G.H., Hwang J.I., Park C.R., Kim J.I., Kim K., Vaudry H., Seong J.Y.
    Endocrinology 155:1864-1873(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A RECEPTOR FOR SPEXIN-1.

Entry informationi

Entry nameiGALR3_HUMAN
AccessioniPrimary (citable) accession number: O60755
Secondary accession number(s): Q53YJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: January 7, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.