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O60755

- GALR3_HUMAN

UniProt

O60755 - GALR3_HUMAN

Protein

Galanin receptor type 3

Gene

GALR3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Receptor for the hormone galanin. Receptor for the hormone spexin-1 (PubMed:24517231).1 Publication

    GO - Molecular functioni

    1. galanin receptor activity Source: UniProtKB
    2. peptide hormone binding Source: UniProtKB

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Ensembl
    2. feeding behavior Source: ProtInc
    3. learning or memory Source: ProtInc
    4. negative regulation of adenylate cyclase activity Source: ProtInc
    5. neuropeptide signaling pathway Source: ProtInc
    6. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    7. synaptic transmission Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galanin receptor type 3
    Short name:
    GAL3-R
    Short name:
    GALR-3
    Gene namesi
    Name:GALR3
    Synonyms:GALNR3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:4134. GALR3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28547.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 368368Galanin receptor type 3PRO_0000069469Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi95 ↔ 172PROSITE-ProRule annotation
    Lipidationi308 – 3081S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiO60755.
    PRIDEiO60755.

    PTM databases

    PhosphoSiteiO60755.

    Expressioni

    Gene expression databases

    BgeeiO60755.
    CleanExiHS_GALR3.
    GenevestigatoriO60755.

    Interactioni

    Protein-protein interaction databases

    BioGridi114058. 1 interaction.
    STRINGi9606.ENSP00000249041.

    Structurei

    3D structure databases

    ProteinModelPortaliO60755.
    SMRiO60755. Positions 18-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2020ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini42 – 5716CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini79 – 9618ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini119 – 13820CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini160 – 18425ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini206 – 23631CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini258 – 2592ExtracellularSequence Analysis
    Topological domaini281 – 36888CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei97 – 11822Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei139 – 15921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei185 – 20521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi218 – 2258Poly-Ala
    Compositional biasi310 – 3189Poly-Arg

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320953.
    HOGENOMiHOG000230487.
    HOVERGENiHBG101447.
    InParanoidiO60755.
    KOiK04232.
    OMAiLWPCGRR.
    OrthoDBiEOG7327PK.
    PhylomeDBiO60755.
    TreeFamiTF315737.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000405. Galanin_rcpt.
    IPR003908. Galnin_3_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01420. GALANIN3R.
    PR00663. GALANINR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O60755-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADAQNISLD SPGSVGAVAV PVVFALIFLL GTVGNGLVLA VLLQPGPSAW    50
    QEPGSTTDLF ILNLAVADLC FILCCVPFQA TIYTLDAWLF GALVCKAVHL 100
    LIYLTMYASS FTLAAVSVDR YLAVRHPLRS RALRTPRNAR AAVGLVWLLA 150
    ALFSAPYLSY YGTVRYGALE LCVPAWEDAR RRALDVATFA AGYLLPVAVV 200
    SLAYGRTLRF LWAAVGPAGA AAAEARRRAT GRAGRAMLAV AALYALCWGP 250
    HHALILCFWY GRFAFSPATY ACRLASHCLA YANSCLNPLV YALASRHFRA 300
    RFRRLWPCGR RRRHRARRAL RRVRPASSGP PGCPGDARPS GRLLAGGGQG 350
    PEPREGPVHG GEAARGPE 368
    Length:368
    Mass (Da):39,573
    Last modified:August 1, 1998 - v1
    Checksum:iE8F46B66422C3150
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti342 – 3421R → G.
    Corresponds to variant rs8137541 [ dbSNP | Ensembl ].
    VAR_049387
    Natural varianti349 – 3491Q → R.
    Corresponds to variant rs8137553 [ dbSNP | Ensembl ].
    VAR_059322

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF073799 mRNA. Translation: AAC35944.1.
    AF067733 mRNA. Translation: AAC18860.1.
    AF129514, AF129513 Genomic DNA. Translation: AAD47348.2.
    AY587582 mRNA. Translation: AAS98215.1.
    AB065934 Genomic DNA. Translation: BAC06149.1.
    Z97630 Genomic DNA. Translation: CAB42831.1.
    CH471095 Genomic DNA. Translation: EAW60191.1.
    CCDSiCCDS13958.1.
    RefSeqiNP_003605.1. NM_003614.1.
    UniGeneiHs.158353.

    Genome annotation databases

    EnsembliENST00000249041; ENSP00000249041; ENSG00000128310.
    GeneIDi8484.
    KEGGihsa:8484.
    UCSCiuc003aub.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF073799 mRNA. Translation: AAC35944.1 .
    AF067733 mRNA. Translation: AAC18860.1 .
    AF129514 , AF129513 Genomic DNA. Translation: AAD47348.2 .
    AY587582 mRNA. Translation: AAS98215.1 .
    AB065934 Genomic DNA. Translation: BAC06149.1 .
    Z97630 Genomic DNA. Translation: CAB42831.1 .
    CH471095 Genomic DNA. Translation: EAW60191.1 .
    CCDSi CCDS13958.1.
    RefSeqi NP_003605.1. NM_003614.1.
    UniGenei Hs.158353.

    3D structure databases

    ProteinModelPortali O60755.
    SMRi O60755. Positions 18-305.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114058. 1 interaction.
    STRINGi 9606.ENSP00000249041.

    Chemistry

    BindingDBi O60755.
    ChEMBLi CHEMBL2731.
    GuidetoPHARMACOLOGYi 245.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O60755.

    Proteomic databases

    PaxDbi O60755.
    PRIDEi O60755.

    Protocols and materials databases

    DNASUi 8484.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000249041 ; ENSP00000249041 ; ENSG00000128310 .
    GeneIDi 8484.
    KEGGi hsa:8484.
    UCSCi uc003aub.1. human.

    Organism-specific databases

    CTDi 8484.
    GeneCardsi GC22P038219.
    HGNCi HGNC:4134. GALR3.
    MIMi 603692. gene.
    neXtProti NX_O60755.
    PharmGKBi PA28547.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG320953.
    HOGENOMi HOG000230487.
    HOVERGENi HBG101447.
    InParanoidi O60755.
    KOi K04232.
    OMAi LWPCGRR.
    OrthoDBi EOG7327PK.
    PhylomeDBi O60755.
    TreeFami TF315737.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii Galanin_receptor_3.
    GenomeRNAii 8484.
    NextBioi 31747.
    PROi O60755.
    SOURCEi Search...

    Gene expression databases

    Bgeei O60755.
    CleanExi HS_GALR3.
    Genevestigatori O60755.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000405. Galanin_rcpt.
    IPR003908. Galnin_3_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01420. GALANIN3R.
    PR00663. GALANINR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloned human and rat galanin GALR3 receptors: pharmacology and activation of G-protein inwardly rectifying K+ channels."
      Smith K.E., Walker M.W., Artymyshyn R., Bard J., Borowsky B., Tamm J.A., Yao W.-J., Vaysse P.J.-J., Branchek T.A., Gerald C., Jones K.A.
      J. Biol. Chem. 273:23321-23326(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Homologue of the human galanin 2 receptor gene isolated from a human uterus cDNA library."
      Bennett M.M., Lescoe M.K., Gallipoli P.Z., Ramabhadran T.V.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Uterus.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Structural organization and chromosomal localization of three human galanin receptor genes."
      Iismaa T.P., Fathi Z., Hort Y.J., Iben L.G., Dutton J.L., Baker E., Sutherland G.R., Shine J.
      Ann. N. Y. Acad. Sci. 863:56-63(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Isolation of cDNA coding for galanin receptor 3 (GALR3)."
      Eutsler E.P., Kopatz S.A., Sharma S.V.
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Retina.
    6. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III."
      Kim D.K., Yun S., Son G.H., Hwang J.I., Park C.R., Kim J.I., Kim K., Vaudry H., Seong J.Y.
      Endocrinology 155:1864-1873(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS A RECEPTOR FOR SPEXIN-1.

    Entry informationi

    Entry nameiGALR3_HUMAN
    AccessioniPrimary (citable) accession number: O60755
    Secondary accession number(s): Q53YJ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3