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Protein

Galanin receptor type 3

Gene

GALR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the hormone galanin (PubMed:25691535). Receptor for the hormone spexin-1 (PubMed:24517231).4 Publications

GO - Molecular functioni

  • galanin receptor activity Source: UniProtKB
  • peptide hormone binding Source: UniProtKB

GO - Biological processi

  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: GO_Central
  • chemical synaptic transmission Source: ProtInc
  • feeding behavior Source: ProtInc
  • learning or memory Source: ProtInc
  • negative regulation of adenylate cyclase activity Source: ProtInc
  • neuropeptide signaling pathway Source: ProtInc
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin receptor type 3
Short name:
GAL3-R
Short name:
GALR-3
Gene namesi
Name:GALR3
Synonyms:GALNR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:4134. GALR3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20ExtracellularSequence analysisAdd BLAST20
Transmembranei21 – 41Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini42 – 57CytoplasmicSequence analysisAdd BLAST16
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini79 – 96ExtracellularSequence analysisAdd BLAST18
Transmembranei97 – 118Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini119 – 138CytoplasmicSequence analysisAdd BLAST20
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 184ExtracellularSequence analysisAdd BLAST25
Transmembranei185 – 205Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini206 – 236CytoplasmicSequence analysisAdd BLAST31
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 259ExtracellularSequence analysis2
Transmembranei260 – 280Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini281 – 368CytoplasmicSequence analysisAdd BLAST88

GO - Cellular componenti

  • integral component of membrane Source: ProtInc
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8484.
OpenTargetsiENSG00000128310.
PharmGKBiPA28547.

Chemistry databases

ChEMBLiCHEMBL2731.
GuidetoPHARMACOLOGYi245.

Polymorphism and mutation databases

BioMutaiGALR3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694691 – 368Galanin receptor type 3Add BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 172PROSITE-ProRule annotation
Lipidationi308S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO60755.
PRIDEiO60755.

PTM databases

iPTMnetiO60755.
PhosphoSitePlusiO60755.

Expressioni

Gene expression databases

BgeeiENSG00000128310.
CleanExiHS_GALR3.
GenevisibleiO60755. HS.

Organism-specific databases

HPAiCAB025985.

Interactioni

Protein-protein interaction databases

BioGridi114058. 1 interactor.
STRINGi9606.ENSP00000249041.

Chemistry databases

BindingDBiO60755.

Structurei

3D structure databases

ProteinModelPortaliO60755.
SMRiO60755.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi218 – 225Poly-Ala8
Compositional biasi310 – 318Poly-Arg9

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00860000133695.
HOGENOMiHOG000230487.
HOVERGENiHBG101447.
InParanoidiO60755.
KOiK04232.
OMAiPREGPAH.
OrthoDBiEOG091G0ZDG.
PhylomeDBiO60755.
TreeFamiTF315737.

Family and domain databases

InterProiIPR000405. Galanin_rcpt.
IPR003908. Galnin_3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01420. GALANIN3R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60755-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAQNISLD SPGSVGAVAV PVVFALIFLL GTVGNGLVLA VLLQPGPSAW
60 70 80 90 100
QEPGSTTDLF ILNLAVADLC FILCCVPFQA TIYTLDAWLF GALVCKAVHL
110 120 130 140 150
LIYLTMYASS FTLAAVSVDR YLAVRHPLRS RALRTPRNAR AAVGLVWLLA
160 170 180 190 200
ALFSAPYLSY YGTVRYGALE LCVPAWEDAR RRALDVATFA AGYLLPVAVV
210 220 230 240 250
SLAYGRTLRF LWAAVGPAGA AAAEARRRAT GRAGRAMLAV AALYALCWGP
260 270 280 290 300
HHALILCFWY GRFAFSPATY ACRLASHCLA YANSCLNPLV YALASRHFRA
310 320 330 340 350
RFRRLWPCGR RRRHRARRAL RRVRPASSGP PGCPGDARPS GRLLAGGGQG
360
PEPREGPVHG GEAARGPE
Length:368
Mass (Da):39,573
Last modified:August 1, 1998 - v1
Checksum:iE8F46B66422C3150
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049387342R → G.Corresponds to variant rs8137541dbSNPEnsembl.1
Natural variantiVAR_059322349Q → R.Corresponds to variant rs8137553dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073799 mRNA. Translation: AAC35944.1.
AF067733 mRNA. Translation: AAC18860.1.
AF129514, AF129513 Genomic DNA. Translation: AAD47348.2.
AY587582 mRNA. Translation: AAS98215.1.
AB065934 Genomic DNA. Translation: BAC06149.1.
Z97630 Genomic DNA. Translation: CAB42831.1.
CH471095 Genomic DNA. Translation: EAW60191.1.
CCDSiCCDS13958.1.
RefSeqiNP_003605.1. NM_003614.1.
UniGeneiHs.158353.

Genome annotation databases

EnsembliENST00000249041; ENSP00000249041; ENSG00000128310.
GeneIDi8484.
KEGGihsa:8484.
UCSCiuc003aub.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073799 mRNA. Translation: AAC35944.1.
AF067733 mRNA. Translation: AAC18860.1.
AF129514, AF129513 Genomic DNA. Translation: AAD47348.2.
AY587582 mRNA. Translation: AAS98215.1.
AB065934 Genomic DNA. Translation: BAC06149.1.
Z97630 Genomic DNA. Translation: CAB42831.1.
CH471095 Genomic DNA. Translation: EAW60191.1.
CCDSiCCDS13958.1.
RefSeqiNP_003605.1. NM_003614.1.
UniGeneiHs.158353.

3D structure databases

ProteinModelPortaliO60755.
SMRiO60755.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114058. 1 interactor.
STRINGi9606.ENSP00000249041.

Chemistry databases

BindingDBiO60755.
ChEMBLiCHEMBL2731.
GuidetoPHARMACOLOGYi245.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO60755.
PhosphoSitePlusiO60755.

Polymorphism and mutation databases

BioMutaiGALR3.

Proteomic databases

PaxDbiO60755.
PRIDEiO60755.

Protocols and materials databases

DNASUi8484.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000249041; ENSP00000249041; ENSG00000128310.
GeneIDi8484.
KEGGihsa:8484.
UCSCiuc003aub.1. human.

Organism-specific databases

CTDi8484.
DisGeNETi8484.
GeneCardsiGALR3.
HGNCiHGNC:4134. GALR3.
HPAiCAB025985.
MIMi603692. gene.
neXtProtiNX_O60755.
OpenTargetsiENSG00000128310.
PharmGKBiPA28547.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00860000133695.
HOGENOMiHOG000230487.
HOVERGENiHBG101447.
InParanoidiO60755.
KOiK04232.
OMAiPREGPAH.
OrthoDBiEOG091G0ZDG.
PhylomeDBiO60755.
TreeFamiTF315737.

Enzyme and pathway databases

ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiGalanin_receptor_3.
GenomeRNAii8484.
PROiO60755.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128310.
CleanExiHS_GALR3.
GenevisibleiO60755. HS.

Family and domain databases

InterProiIPR000405. Galanin_rcpt.
IPR003908. Galnin_3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01420. GALANIN3R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGALR3_HUMAN
AccessioniPrimary (citable) accession number: O60755
Secondary accession number(s): Q53YJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.