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O60749

- SNX2_HUMAN

UniProt

O60749 - SNX2_HUMAN

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Protein

Sorting nexin-2

Gene

SNX2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei183 – 1831Phosphatidylinositol 3-phosphateBy similarity
Binding sitei185 – 1851Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei211 – 2111Phosphatidylinositol 3-phosphateBy similarity
Binding sitei235 – 2351Phosphatidylinositol 3-phosphateBy similarity

GO - Molecular functioni

  1. epidermal growth factor receptor binding Source: UniProtKB
  2. insulin receptor binding Source: UniProtKB
  3. leptin receptor binding Source: UniProtKB
  4. phosphatidylinositol binding Source: RefGenome
  5. transferrin receptor binding Source: UniProtKB

GO - Biological processi

  1. endocytosis Source: InterPro
  2. intracellular protein transport Source: RefGenome
  3. protein oligomerization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiREACT_19400. Golgi Associated Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-2
Alternative name(s):
Transformation-related gene 9 protein
Short name:
TRG-9
Gene namesi
Name:SNX2
ORF Names:TRG9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:11173. SNX2.

Subcellular locationi

Early endosome membrane 2 Publications; Peripheral membrane protein 2 Publications; Cytoplasmic side 2 Publications

GO - Cellular componenti

  1. cytoplasm Source: HGNC
  2. cytoplasmic membrane-bounded vesicle Source: RefGenome
  3. endosome membrane Source: UniProtKB
  4. extracellular vesicular exosome Source: UniProt
  5. intracellular membrane-bounded organelle Source: HPA
  6. membrane Source: UniProtKB
  7. protein complex Source: UniProtKB
  8. retromer complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi211 – 2111K → A: Abolishes phosphatidylinositol phosphate binding. Abolishes endosomal location. 1 Publication

Organism-specific databases

PharmGKBiPA36012.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519Sorting nexin-2PRO_0000213838Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei119 – 1191Phosphoserine1 Publication
Modified residuei185 – 1851Phosphoserine1 Publication
Modified residuei277 – 2771Phosphoserine2 Publications
Modified residuei469 – 4691N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO60749.
PaxDbiO60749.
PeptideAtlasiO60749.
PRIDEiO60749.

PTM databases

PhosphoSiteiO60749.

Expressioni

Gene expression databases

BgeeiO60749.
CleanExiHS_SNX2.
ExpressionAtlasiO60749. baseline and differential.
GenevestigatoriO60749.

Organism-specific databases

HPAiHPA037400.

Interactioni

Subunit structurei

Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Interacts with FNBP1. Interacts with SNX6.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FNBP1Q96RU34EBI-1046690,EBI-1111248

Protein-protein interaction databases

BioGridi112526. 48 interactions.
IntActiO60749. 16 interactions.
MINTiMINT-5000817.
STRINGi9606.ENSP00000368831.

Structurei

3D structure databases

ProteinModelPortaliO60749.
SMRiO60749. Positions 140-510.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini140 – 269130PXPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5391.
GeneTreeiENSGT00760000119259.
HOVERGENiHBG000618.
InParanoidiO60749.
KOiK17917.
OMAiCEEHTGL.
OrthoDBiEOG7HHWSB.
PhylomeDBiO60749.
TreeFamiTF313698.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR028653. SNX2.
IPR005329. Sorting_nexin_N.
IPR015404. Vps5_C.
[Graphical view]
PANTHERiPTHR10555:SF31. PTHR10555:SF31. 1 hit.
PfamiPF00787. PX. 1 hit.
PF03700. Sorting_nexin. 1 hit.
PF09325. Vps5. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O60749-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAEREPPPL GDGKPTDFED LEDGEDLFTS TVSTLESSPS SPEPASLPAE
60 70 80 90 100
DISANSNGPK PTEVVLDDDR EDLFAEATEE VSLDSPEREP ILSSEPSPAV
110 120 130 140 150
TPVTPTTLIA PRIESKSMSA PVIFDRSREE IEEEANGDIF DIEIGVSDPE
160 170 180 190 200
KVGDGMNAYM AYRVTTKTSL SMFSKSEFSV KRRFSDFLGL HSKLASKYLH
210 220 230 240 250
VGYIVPPAPE KSIVGMTKVK VGKEDSSSTE FVEKRRAALE RYLQRTVKHP
260 270 280 290 300
TLLQDPDLRQ FLESSELPRA VNTQALSGAG ILRMVNKAAD AVNKMTIKMN
310 320 330 340 350
ESDAWFEEKQ QQFENLDQQL RKLHVSVEAL VCHRKELSAN TAAFAKSAAM
360 370 380 390 400
LGNSEDHTAL SRALSQLAEV EEKIDQLHQE QAFADFYMFS ELLSDYIRLI
410 420 430 440 450
AAVKGVFDHR MKCWQKWEDA QITLLKKREA EAKMMVANKP DKIQQAKNEI
460 470 480 490 500
REWEAKVQQG ERDFEQISKT IRKEVGRFEK ERVKDFKTVI IKYLESLVQT
510
QQQLIKYWEA FLPEAKAIA
Length:519
Mass (Da):58,471
Last modified:May 30, 2006 - v2
Checksum:i7DC07DFA523312B5
GO
Isoform 2 (identifier: O60749-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-117: Missing.

Show »
Length:402
Mass (Da):46,098
Checksum:i4CF80EFD3B9C160D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti87 – 871E → A in AAQ02693. 1 PublicationCurated
Sequence conflicti146 – 1461V → I in BAH12394. (PubMed:14702039)Curated
Sequence conflicti331 – 3311V → F1 PublicationCurated
Sequence conflicti331 – 3311V → F(PubMed:9819414)Curated
Sequence conflicti384 – 3841A → S1 PublicationCurated
Sequence conflicti384 – 3841A → S(PubMed:9819414)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 117117Missing in isoform 2. 1 PublicationVSP_054785Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF065482 mRNA. Translation: AAC17181.1.
AF043453 mRNA. Translation: AAB99852.1.
AY272044 mRNA. Translation: AAQ02693.1.
BT009841 mRNA. Translation: AAP88843.1.
AK023581 mRNA. Translation: BAG51206.1.
AK293671 mRNA. Translation: BAG57115.1.
AK296596 mRNA. Translation: BAH12394.1.
AC008669 Genomic DNA. No translation available.
AC093267 Genomic DNA. No translation available.
CH471086 Genomic DNA. Translation: EAW48884.1.
BC003382 mRNA. Translation: AAH03382.1.
CCDSiCCDS34217.1. [O60749-1]
CCDS64234.1. [O60749-2]
RefSeqiNP_001265128.1. NM_001278199.1. [O60749-2]
NP_003091.2. NM_003100.3. [O60749-1]
UniGeneiHs.125352.
Hs.713554.

Genome annotation databases

EnsembliENST00000379516; ENSP00000368831; ENSG00000205302. [O60749-1]
ENST00000514949; ENSP00000421663; ENSG00000205302. [O60749-2]
GeneIDi6643.
KEGGihsa:6643.
UCSCiuc003kte.4. human. [O60749-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF065482 mRNA. Translation: AAC17181.1 .
AF043453 mRNA. Translation: AAB99852.1 .
AY272044 mRNA. Translation: AAQ02693.1 .
BT009841 mRNA. Translation: AAP88843.1 .
AK023581 mRNA. Translation: BAG51206.1 .
AK293671 mRNA. Translation: BAG57115.1 .
AK296596 mRNA. Translation: BAH12394.1 .
AC008669 Genomic DNA. No translation available.
AC093267 Genomic DNA. No translation available.
CH471086 Genomic DNA. Translation: EAW48884.1 .
BC003382 mRNA. Translation: AAH03382.1 .
CCDSi CCDS34217.1. [O60749-1 ]
CCDS64234.1. [O60749-2 ]
RefSeqi NP_001265128.1. NM_001278199.1. [O60749-2 ]
NP_003091.2. NM_003100.3. [O60749-1 ]
UniGenei Hs.125352.
Hs.713554.

3D structure databases

ProteinModelPortali O60749.
SMRi O60749. Positions 140-510.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112526. 48 interactions.
IntActi O60749. 16 interactions.
MINTi MINT-5000817.
STRINGi 9606.ENSP00000368831.

PTM databases

PhosphoSitei O60749.

Proteomic databases

MaxQBi O60749.
PaxDbi O60749.
PeptideAtlasi O60749.
PRIDEi O60749.

Protocols and materials databases

DNASUi 6643.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000379516 ; ENSP00000368831 ; ENSG00000205302 . [O60749-1 ]
ENST00000514949 ; ENSP00000421663 ; ENSG00000205302 . [O60749-2 ]
GeneIDi 6643.
KEGGi hsa:6643.
UCSCi uc003kte.4. human. [O60749-1 ]

Organism-specific databases

CTDi 6643.
GeneCardsi GC05P122110.
HGNCi HGNC:11173. SNX2.
HPAi HPA037400.
MIMi 605929. gene.
neXtProti NX_O60749.
PharmGKBi PA36012.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5391.
GeneTreei ENSGT00760000119259.
HOVERGENi HBG000618.
InParanoidi O60749.
KOi K17917.
OMAi CEEHTGL.
OrthoDBi EOG7HHWSB.
PhylomeDBi O60749.
TreeFami TF313698.

Enzyme and pathway databases

Reactomei REACT_19400. Golgi Associated Vesicle Biogenesis.

Miscellaneous databases

ChiTaRSi SNX2. human.
GeneWikii SNX2.
GenomeRNAii 6643.
NextBioi 25889.
PROi O60749.
SOURCEi Search...

Gene expression databases

Bgeei O60749.
CleanExi HS_SNX2.
ExpressionAtlasi O60749. baseline and differential.
Genevestigatori O60749.

Family and domain databases

Gene3Di 3.30.1520.10. 1 hit.
InterProi IPR001683. Phox.
IPR028653. SNX2.
IPR005329. Sorting_nexin_N.
IPR015404. Vps5_C.
[Graphical view ]
PANTHERi PTHR10555:SF31. PTHR10555:SF31. 1 hit.
Pfami PF00787. PX. 1 hit.
PF03700. Sorting_nexin. 1 hit.
PF09325. Vps5. 1 hit.
[Graphical view ]
SMARTi SM00312. PX. 1 hit.
[Graphical view ]
SUPFAMi SSF64268. SSF64268. 1 hit.
PROSITEi PS50195. PX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Kurten R.C., Leychkis Y., Wiley H.S., Gill G.N.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH VPS26A; VPS29; VPS35 AND SNX1.
    Tissue: Placenta.
  2. "Identification of a family of sorting nexin molecules and characterization of their association with receptors."
    Haft C.R., de la Luz Sierra M., Barr V.A., Haft D.H., Taylor S.I.
    Mol. Cell. Biol. 18:7278-7287(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Identification of a human transforming gene."
    Kim J.W.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Cerebellum, Colon and Placenta.
  6. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  9. "The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia."
    Fuchs U., Rehkamp G.F., Haas O.A., Slany R., Koenig M., Bojesen S., Bohle R.M., Damm-Welk C., Ludwig W.-D., Harbott J., Borkhardt A.
    Proc. Natl. Acad. Sci. U.S.A. 98:8756-8761(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FNBP1.
  10. "The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance."
    Fuchs U., Rehkamp G.F., Slany R., Follo M., Borkhardt A.
    FEBS Lett. 554:10-16(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FNBP1.
  11. "Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport."
    Carlton J.G., Bujny M.V., Peter B.J., Oorschot V.M., Rutherford A., Arkell R.S., Klumperman J., McMahon H.T., Cullen P.J.
    J. Cell Sci. 118:4527-4539(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF LYS-211, SUBCELLULAR LOCATION.
  12. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-277, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors."
    Rojas R., Kametaka S., Haft C.R., Bonifacino J.S.
    Mol. Cell. Biol. 27:1112-1124(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, SUBUNIT.
  14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-119 AND SER-185, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. "The retromer component SNX6 interacts with dynactin p150(Glued) and mediates endosome-to-TGN transport."
    Hong Z., Yang Y., Zhang C., Niu Y., Li K., Zhao X., Liu J.J.
    Cell Res. 19:1334-1349(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SNX6.
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  17. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-469, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-277, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSNX2_HUMAN
AccessioniPrimary (citable) accession number: O60749
Secondary accession number(s): B3KN44
, B4DEK4, B7Z408, O43650, P82862, Q53XK8, Q597H6, Q9BTS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 30, 2006
Last modified: October 29, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3