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O60739

- EIF1B_HUMAN

UniProt

O60739 - EIF1B_HUMAN

Protein

Eukaryotic translation initiation factor 1b

Gene

EIF1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Probably involved in translation.

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. translation initiation factor activity Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of translational initiation Source: UniProtKB

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eukaryotic translation initiation factor 1b
    Short name:
    eIF1b
    Alternative name(s):
    Protein translation factor SUI1 homolog GC20
    Gene namesi
    Name:EIF1B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:30792. EIF1B.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485452.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 113112Eukaryotic translation initiation factor 1bPRO_0000130558Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Modified residuei9 – 91Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO60739.
    PaxDbiO60739.
    PRIDEiO60739.

    PTM databases

    PhosphoSiteiO60739.

    Expressioni

    Gene expression databases

    ArrayExpressiO60739.
    BgeeiO60739.
    CleanExiHS_EIF1B.
    GenevestigatoriO60739.

    Organism-specific databases

    HPAiHPA043003.

    Interactioni

    Protein-protein interaction databases

    BioGridi115578. 34 interactions.
    IntActiO60739. 4 interactions.
    STRINGi9606.ENSP00000232905.

    Structurei

    3D structure databases

    ProteinModelPortaliO60739.
    SMRiO60739. Positions 1-113.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SUI1 family.Curated

    Phylogenomic databases

    eggNOGiCOG0023.
    HOGENOMiHOG000279813.
    HOVERGENiHBG000295.
    InParanoidiO60739.
    KOiK03113.
    OMAiNICQFLT.
    OrthoDBiEOG76QFKK.
    PhylomeDBiO60739.
    TreeFamiTF314417.

    Family and domain databases

    Gene3Di3.30.780.10. 1 hit.
    InterProiIPR005874. SUI1_euk.
    IPR001950. TIF_SUI1.
    [Graphical view]
    PfamiPF01253. SUI1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004499. SUI1_euk. 1 hit.
    SUPFAMiSSF55159. SSF55159. 1 hit.
    TIGRFAMsiTIGR01160. SUI1_MOF2. 1 hit.
    PROSITEiPS50296. SUI1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O60739-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTIQNLQSF DPFADATKGD DLLPAGTEDY IHIRIQQRNG RKTLTTVQGI    50
    ADDYDKKKLV KAFKKKFACN GTVIEHPEYG EVIQLQGDQR KNICQFLLEV 100
    GIVKEEQLKV HGF 113
    Length:113
    Mass (Da):12,824
    Last modified:December 1, 2000 - v2
    Checksum:i4522A8B692654FE1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 271T → L in AAC17112. 1 PublicationCurated
    Sequence conflicti41 – 411R → G in AAC17112. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF064607 mRNA. Translation: AAC17112.1.
    AF077052 mRNA. Translation: AAD27785.1.
    AF263452 mRNA. Translation: AAF79182.1.
    BC006996 mRNA. Translation: AAH06996.1.
    CCDSiCCDS2690.1.
    RefSeqiNP_005866.1. NM_005875.2.
    UniGeneiHs.315230.

    Genome annotation databases

    EnsembliENST00000232905; ENSP00000232905; ENSG00000114784.
    GeneIDi10289.
    KEGGihsa:10289.
    UCSCiuc003ckc.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF064607 mRNA. Translation: AAC17112.1 .
    AF077052 mRNA. Translation: AAD27785.1 .
    AF263452 mRNA. Translation: AAF79182.1 .
    BC006996 mRNA. Translation: AAH06996.1 .
    CCDSi CCDS2690.1.
    RefSeqi NP_005866.1. NM_005875.2.
    UniGenei Hs.315230.

    3D structure databases

    ProteinModelPortali O60739.
    SMRi O60739. Positions 1-113.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115578. 34 interactions.
    IntActi O60739. 4 interactions.
    STRINGi 9606.ENSP00000232905.

    PTM databases

    PhosphoSitei O60739.

    Proteomic databases

    MaxQBi O60739.
    PaxDbi O60739.
    PRIDEi O60739.

    Protocols and materials databases

    DNASUi 10289.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000232905 ; ENSP00000232905 ; ENSG00000114784 .
    GeneIDi 10289.
    KEGGi hsa:10289.
    UCSCi uc003ckc.3. human.

    Organism-specific databases

    CTDi 10289.
    GeneCardsi GC03P040351.
    HGNCi HGNC:30792. EIF1B.
    HPAi HPA043003.
    neXtProti NX_O60739.
    PharmGKBi PA143485452.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0023.
    HOGENOMi HOG000279813.
    HOVERGENi HBG000295.
    InParanoidi O60739.
    KOi K03113.
    OMAi NICQFLT.
    OrthoDBi EOG76QFKK.
    PhylomeDBi O60739.
    TreeFami TF314417.

    Miscellaneous databases

    GeneWikii EIF1B.
    GenomeRNAii 10289.
    NextBioi 38988.
    PROi O60739.

    Gene expression databases

    ArrayExpressi O60739.
    Bgeei O60739.
    CleanExi HS_EIF1B.
    Genevestigatori O60739.

    Family and domain databases

    Gene3Di 3.30.780.10. 1 hit.
    InterProi IPR005874. SUI1_euk.
    IPR001950. TIF_SUI1.
    [Graphical view ]
    Pfami PF01253. SUI1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004499. SUI1_euk. 1 hit.
    SUPFAMi SSF55159. SSF55159. 1 hit.
    TIGRFAMsi TIGR01160. SUI1_MOF2. 1 hit.
    PROSITEi PS50296. SUI1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human dendritic cell SUI1 homolog gene."
      Zhao Z., Huang X., Li N., Zhu X., Cao X.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Blood.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary.
    3. "Homo sapiens translational factor eIF-1."
      Kim D.-G., You K.-R.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    5. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiEIF1B_HUMAN
    AccessioniPrimary (citable) accession number: O60739
    Secondary accession number(s): Q9UQF8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Translation initiation factors
      List of translation initiation factor entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3