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O60739 (EIF1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Eukaryotic translation initiation factor 1b

Short name=eIF1b
Alternative name(s):
Protein translation factor SUI1 homolog GC20
Gene names
Name:EIF1B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length113 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probably involved in translation.

Sequence similarities

Belongs to the SUI1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5
Chain2 – 113112Eukaryotic translation initiation factor 1b
PRO_0000130558

Amino acid modifications

Modified residue21N-acetylserine Ref.5
Modified residue91Phosphoserine Ref.5

Experimental info

Sequence conflict271T → L in AAC17112. Ref.1
Sequence conflict411R → G in AAC17112. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O60739 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: 4522A8B692654FE1

FASTA11312,824
        10         20         30         40         50         60 
MSTIQNLQSF DPFADATKGD DLLPAGTEDY IHIRIQQRNG RKTLTTVQGI ADDYDKKKLV 

        70         80         90        100        110 
KAFKKKFACN GTVIEHPEYG EVIQLQGDQR KNICQFLLEV GIVKEEQLKV HGF 

« Hide

References

« Hide 'large scale' references
[1]"Human dendritic cell SUI1 homolog gene."
Zhao Z., Huang X., Li N., Zhu X., Cao X.
Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Blood.
[2]"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. expand/collapse author list , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pituitary.
[3]"Homo sapiens translational factor eIF-1."
Kim D.-G., You K.-R.
Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[5]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF064607 mRNA. Translation: AAC17112.1.
AF077052 mRNA. Translation: AAD27785.1.
AF263452 mRNA. Translation: AAF79182.1.
BC006996 mRNA. Translation: AAH06996.1.
CCDSCCDS2690.1.
RefSeqNP_005866.1. NM_005875.2.
UniGeneHs.315230.

3D structure databases

ProteinModelPortalO60739.
SMRO60739. Positions 1-113.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115578. 34 interactions.
IntActO60739. 4 interactions.
STRING9606.ENSP00000232905.

PTM databases

PhosphoSiteO60739.

Proteomic databases

MaxQBO60739.
PaxDbO60739.
PRIDEO60739.

Protocols and materials databases

DNASU10289.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000232905; ENSP00000232905; ENSG00000114784.
GeneID10289.
KEGGhsa:10289.
UCSCuc003ckc.3. human.

Organism-specific databases

CTD10289.
GeneCardsGC03P040351.
HGNCHGNC:30792. EIF1B.
HPAHPA043003.
neXtProtNX_O60739.
PharmGKBPA143485452.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0023.
HOGENOMHOG000279813.
HOVERGENHBG000295.
InParanoidO60739.
KOK03113.
OMANICQFLT.
OrthoDBEOG76QFKK.
PhylomeDBO60739.
TreeFamTF314417.

Gene expression databases

ArrayExpressO60739.
BgeeO60739.
CleanExHS_EIF1B.
GenevestigatorO60739.

Family and domain databases

Gene3D3.30.780.10. 1 hit.
InterProIPR005874. SUI1_euk.
IPR001950. TIF_SUI1.
[Graphical view]
PfamPF01253. SUI1. 1 hit.
[Graphical view]
PIRSFPIRSF004499. SUI1_euk. 1 hit.
SUPFAMSSF55159. SSF55159. 1 hit.
TIGRFAMsTIGR01160. SUI1_MOF2. 1 hit.
PROSITEPS50296. SUI1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiEIF1B.
GenomeRNAi10289.
NextBio38988.
PROO60739.

Entry information

Entry nameEIF1B_HUMAN
AccessionPrimary (citable) accession number: O60739
Secondary accession number(s): Q9UQF8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 1, 2000
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM