Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O60739

- EIF1B_HUMAN

UniProt

O60739 - EIF1B_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Eukaryotic translation initiation factor 1b

Gene

EIF1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Probably involved in translation.

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. translation initiation factor activity Source: UniProtKB-KW

GO - Biological processi

  1. regulation of translational initiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 1b
Short name:
eIF1b
Alternative name(s):
Protein translation factor SUI1 homolog GC20
Gene namesi
Name:EIF1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:30792. EIF1B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485452.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 113112Eukaryotic translation initiation factor 1bPRO_0000130558Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei9 – 91Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO60739.
PaxDbiO60739.
PRIDEiO60739.

PTM databases

PhosphoSiteiO60739.

Expressioni

Gene expression databases

BgeeiO60739.
CleanExiHS_EIF1B.
ExpressionAtlasiO60739. baseline and differential.
GenevestigatoriO60739.

Organism-specific databases

HPAiHPA043003.

Interactioni

Protein-protein interaction databases

BioGridi115578. 34 interactions.
IntActiO60739. 4 interactions.
STRINGi9606.ENSP00000232905.

Structurei

3D structure databases

ProteinModelPortaliO60739.
SMRiO60739. Positions 1-113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SUI1 family.Curated

Phylogenomic databases

eggNOGiCOG0023.
HOGENOMiHOG000279813.
HOVERGENiHBG000295.
InParanoidiO60739.
KOiK03113.
OMAiNICQFLT.
OrthoDBiEOG76QFKK.
PhylomeDBiO60739.
TreeFamiTF314417.

Family and domain databases

Gene3Di3.30.780.10. 1 hit.
InterProiIPR005874. SUI1_euk.
IPR001950. TIF_SUI1.
[Graphical view]
PfamiPF01253. SUI1. 1 hit.
[Graphical view]
PIRSFiPIRSF004499. SUI1_euk. 1 hit.
SUPFAMiSSF55159. SSF55159. 1 hit.
TIGRFAMsiTIGR01160. SUI1_MOF2. 1 hit.
PROSITEiPS50296. SUI1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60739-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTIQNLQSF DPFADATKGD DLLPAGTEDY IHIRIQQRNG RKTLTTVQGI
60 70 80 90 100
ADDYDKKKLV KAFKKKFACN GTVIEHPEYG EVIQLQGDQR KNICQFLLEV
110
GIVKEEQLKV HGF
Length:113
Mass (Da):12,824
Last modified:December 1, 2000 - v2
Checksum:i4522A8B692654FE1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271T → L in AAC17112. 1 PublicationCurated
Sequence conflicti41 – 411R → G in AAC17112. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF064607 mRNA. Translation: AAC17112.1.
AF077052 mRNA. Translation: AAD27785.1.
AF263452 mRNA. Translation: AAF79182.1.
BC006996 mRNA. Translation: AAH06996.1.
CCDSiCCDS2690.1.
RefSeqiNP_005866.1. NM_005875.2.
UniGeneiHs.315230.

Genome annotation databases

EnsembliENST00000232905; ENSP00000232905; ENSG00000114784.
GeneIDi10289.
KEGGihsa:10289.
UCSCiuc003ckc.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF064607 mRNA. Translation: AAC17112.1 .
AF077052 mRNA. Translation: AAD27785.1 .
AF263452 mRNA. Translation: AAF79182.1 .
BC006996 mRNA. Translation: AAH06996.1 .
CCDSi CCDS2690.1.
RefSeqi NP_005866.1. NM_005875.2.
UniGenei Hs.315230.

3D structure databases

ProteinModelPortali O60739.
SMRi O60739. Positions 1-113.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115578. 34 interactions.
IntActi O60739. 4 interactions.
STRINGi 9606.ENSP00000232905.

PTM databases

PhosphoSitei O60739.

Proteomic databases

MaxQBi O60739.
PaxDbi O60739.
PRIDEi O60739.

Protocols and materials databases

DNASUi 10289.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000232905 ; ENSP00000232905 ; ENSG00000114784 .
GeneIDi 10289.
KEGGi hsa:10289.
UCSCi uc003ckc.3. human.

Organism-specific databases

CTDi 10289.
GeneCardsi GC03P040351.
HGNCi HGNC:30792. EIF1B.
HPAi HPA043003.
neXtProti NX_O60739.
PharmGKBi PA143485452.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0023.
HOGENOMi HOG000279813.
HOVERGENi HBG000295.
InParanoidi O60739.
KOi K03113.
OMAi NICQFLT.
OrthoDBi EOG76QFKK.
PhylomeDBi O60739.
TreeFami TF314417.

Miscellaneous databases

GeneWikii EIF1B.
GenomeRNAii 10289.
NextBioi 38988.
PROi O60739.

Gene expression databases

Bgeei O60739.
CleanExi HS_EIF1B.
ExpressionAtlasi O60739. baseline and differential.
Genevestigatori O60739.

Family and domain databases

Gene3Di 3.30.780.10. 1 hit.
InterProi IPR005874. SUI1_euk.
IPR001950. TIF_SUI1.
[Graphical view ]
Pfami PF01253. SUI1. 1 hit.
[Graphical view ]
PIRSFi PIRSF004499. SUI1_euk. 1 hit.
SUPFAMi SSF55159. SSF55159. 1 hit.
TIGRFAMsi TIGR01160. SUI1_MOF2. 1 hit.
PROSITEi PS50296. SUI1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human dendritic cell SUI1 homolog gene."
    Zhao Z., Huang X., Li N., Zhu X., Cao X.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Blood.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  3. "Homo sapiens translational factor eIF-1."
    Kim D.-G., You K.-R.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  5. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiEIF1B_HUMAN
AccessioniPrimary (citable) accession number: O60739
Secondary accession number(s): Q9UQF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 1, 2000
Last modified: October 29, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Translation initiation factors
    List of translation initiation factor entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3