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Protein

Eukaryotic translation initiation factor 1b

Gene

EIF1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in translation.

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • translation initiation factor activity Source: UniProtKB-KW

GO - Biological processi

  • regulation of translational initiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000114784-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 1b
Short name:
eIF1b
Alternative name(s):
Protein translation factor SUI1 homolog GC20
Gene namesi
Name:EIF1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30792. EIF1B.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000114784.
PharmGKBiPA143485452.

Polymorphism and mutation databases

BioMutaiEIF1B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001305582 – 113Eukaryotic translation initiation factor 1bAdd BLAST112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei9PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO60739.
PaxDbiO60739.
PeptideAtlasiO60739.
PRIDEiO60739.
TopDownProteomicsiO60739.

PTM databases

iPTMnetiO60739.
PhosphoSitePlusiO60739.

Expressioni

Gene expression databases

BgeeiENSG00000114784.
CleanExiHS_EIF1B.
ExpressionAtlasiO60739. baseline and differential.
GenevisibleiO60739. HS.

Interactioni

Protein-protein interaction databases

BioGridi115578. 37 interactors.
IntActiO60739. 5 interactors.
STRINGi9606.ENSP00000232905.

Structurei

3D structure databases

ProteinModelPortaliO60739.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SUI1 family.Curated

Phylogenomic databases

eggNOGiKOG1770. Eukaryota.
COG0023. LUCA.
GeneTreeiENSGT00390000015789.
HOGENOMiHOG000279813.
HOVERGENiHBG000295.
InParanoidiO60739.
KOiK03113.
OMAiLLEINIV.
OrthoDBiEOG091G10OC.
PhylomeDBiO60739.
TreeFamiTF314417.

Family and domain databases

CDDicd11566. eIF1_SUI1. 1 hit.
Gene3Di3.30.780.10. 1 hit.
InterProiIPR001950. SUI1.
IPR005874. SUI1_euk.
[Graphical view]
PfamiPF01253. SUI1. 1 hit.
[Graphical view]
PIRSFiPIRSF004499. SUI1_euk. 1 hit.
SUPFAMiSSF55159. SSF55159. 1 hit.
TIGRFAMsiTIGR01160. SUI1_MOF2. 1 hit.
PROSITEiPS50296. SUI1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60739-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTIQNLQSF DPFADATKGD DLLPAGTEDY IHIRIQQRNG RKTLTTVQGI
60 70 80 90 100
ADDYDKKKLV KAFKKKFACN GTVIEHPEYG EVIQLQGDQR KNICQFLLEV
110
GIVKEEQLKV HGF
Length:113
Mass (Da):12,824
Last modified:December 1, 2000 - v2
Checksum:i4522A8B692654FE1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27T → L in AAC17112 (Ref. 1) Curated1
Sequence conflicti41R → G in AAC17112 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064607 mRNA. Translation: AAC17112.1.
AF077052 mRNA. Translation: AAD27785.1.
AF263452 mRNA. Translation: AAF79182.1.
BC006996 mRNA. Translation: AAH06996.1.
CCDSiCCDS2690.1.
RefSeqiNP_005866.1. NM_005875.2.
UniGeneiHs.315230.

Genome annotation databases

EnsembliENST00000232905; ENSP00000232905; ENSG00000114784.
GeneIDi10289.
KEGGihsa:10289.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064607 mRNA. Translation: AAC17112.1.
AF077052 mRNA. Translation: AAD27785.1.
AF263452 mRNA. Translation: AAF79182.1.
BC006996 mRNA. Translation: AAH06996.1.
CCDSiCCDS2690.1.
RefSeqiNP_005866.1. NM_005875.2.
UniGeneiHs.315230.

3D structure databases

ProteinModelPortaliO60739.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115578. 37 interactors.
IntActiO60739. 5 interactors.
STRINGi9606.ENSP00000232905.

PTM databases

iPTMnetiO60739.
PhosphoSitePlusiO60739.

Polymorphism and mutation databases

BioMutaiEIF1B.

Proteomic databases

EPDiO60739.
PaxDbiO60739.
PeptideAtlasiO60739.
PRIDEiO60739.
TopDownProteomicsiO60739.

Protocols and materials databases

DNASUi10289.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000232905; ENSP00000232905; ENSG00000114784.
GeneIDi10289.
KEGGihsa:10289.

Organism-specific databases

CTDi10289.
GeneCardsiEIF1B.
HGNCiHGNC:30792. EIF1B.
neXtProtiNX_O60739.
OpenTargetsiENSG00000114784.
PharmGKBiPA143485452.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1770. Eukaryota.
COG0023. LUCA.
GeneTreeiENSGT00390000015789.
HOGENOMiHOG000279813.
HOVERGENiHBG000295.
InParanoidiO60739.
KOiK03113.
OMAiLLEINIV.
OrthoDBiEOG091G10OC.
PhylomeDBiO60739.
TreeFamiTF314417.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000114784-MONOMER.

Miscellaneous databases

ChiTaRSiEIF1B. human.
GeneWikiiEIF1B.
GenomeRNAii10289.
PROiO60739.

Gene expression databases

BgeeiENSG00000114784.
CleanExiHS_EIF1B.
ExpressionAtlasiO60739. baseline and differential.
GenevisibleiO60739. HS.

Family and domain databases

CDDicd11566. eIF1_SUI1. 1 hit.
Gene3Di3.30.780.10. 1 hit.
InterProiIPR001950. SUI1.
IPR005874. SUI1_euk.
[Graphical view]
PfamiPF01253. SUI1. 1 hit.
[Graphical view]
PIRSFiPIRSF004499. SUI1_euk. 1 hit.
SUPFAMiSSF55159. SSF55159. 1 hit.
TIGRFAMsiTIGR01160. SUI1_MOF2. 1 hit.
PROSITEiPS50296. SUI1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEIF1B_HUMAN
AccessioniPrimary (citable) accession number: O60739
Secondary accession number(s): Q9UQF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 1, 2000
Last modified: November 30, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Translation initiation factors
    List of translation initiation factor entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.