O60739 (EIF1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Eukaryotic translation initiation factor 1b
Short name=eIF1b

Alternative name(s):
Protein translation factor SUI1 homolog GC20

Gene names

Name:

EIF1B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	113 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probably involved in translation.
Sequence similarities	Belongs to the SUI1 family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Molecular function	Initiation factor
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of translational initiation Non-traceable author statement PubMed 7904817. Source: UniProtKB
Molecular_function	translation initiation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.5
	Chain	2 – 113	112	Eukaryotic translation initiation factor 1b		PRO_0000130558
Amino acid modifications
	Modified residue	2	1	N-acetylserine Ref.5
	Modified residue	9	1	Phosphoserine Ref.5
Experimental info
	Sequence conflict	27	1	T → L in AAC17112. Ref.1
	Sequence conflict	41	1	R → G in AAC17112. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O60739 [UniParc]. Last modified December 1, 2000. Version 2. Checksum: 4522A8B692654FE1	FASTA	113	12,824
	10 20 30 40 50 60 MSTIQNLQSF DPFADATKGD DLLPAGTEDY IHIRIQQRNG RKTLTTVQGI ADDYDKKKLV 70 80 90 100 110 KAFKKKFACN GTVIEHPEYG EVIQLQGDQR KNICQFLLEV GIVKEEQLKV HGF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human dendritic cell SUI1 homolog gene." Zhao Z., Huang X., Li N., Zhu X., Cao X. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Blood.
[2]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pituitary.
[3]	"Homo sapiens translational factor eIF-1." Kim D.-G., You K.-R. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[5]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, MASS SPECTROMETRY, CLEAVAGE OF INITIATOR METHIONINE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF064607 mRNA. Translation: AAC17112.1. AF077052 mRNA. Translation: AAD27785.1. AF263452 mRNA. Translation: AAF79182.1. BC006996 mRNA. Translation: AAH06996.1.
IPI	IPI00031489.
RefSeq	NP_005866.1. NM_005875.2.
UniGene	Hs.315230.
3D structure databases
ProteinModelPortal	O60739.
ModBase	Search...
Protein-protein interaction databases
IntAct	O60739. 3 interactions.
STRING	9606.ENSP00000232905.
PTM databases
PhosphoSite	O60739.
Proteomic databases
PaxDb	O60739.
PRIDE	O60739.
Protocols and materials databases
DNASU	10289.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000232905; ENSP00000232905; ENSG00000114784.
GeneID	10289.
KEGG	hsa:10289.
UCSC	uc003ckc.3. human.
Organism-specific databases
CTD	10289.
GeneCards	GC03P040351.
HGNC	HGNC:30792. EIF1B.
HPA	HPA043003.
neXtProt	NX_O60739.
PharmGKB	PA143485452.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0023.
HOGENOM	HOG000279813.
HOVERGEN	HBG000295.
InParanoid	O60739.
KO	K03113.
OMA	ACNGTLV.
OrthoDB	EOG4XH01M.
PhylomeDB	O60739.
Gene expression databases
ArrayExpress	O60739.
Bgee	O60739.
CleanEx	HS_EIF1B.
Genevestigator	O60739.
GermOnline	ENSG00000114784. Homo sapiens.
Family and domain databases
InterPro	IPR005874. SUI1_euk. IPR001950. TIF_SUI1. [Graphical view]
Pfam	PF01253. SUI1. 1 hit. [Graphical view]
PIRSF	PIRSF004499. SUI1_euk. 1 hit.
SUPFAM	SSF55159. TIF_SUI1. 1 hit.
TIGRFAMs	TIGR01160. SUI1_MOF2. 1 hit.
PROSITE	PS50296. SUI1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	10289.
NextBio	38988.

Entry information

Entry name

EIF1B_HUMAN

Accession

Primary (citable) accession number: O60739
Secondary accession number(s): Q9UQF8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	December 1, 2000
Last modified:	May 1, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.