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O60732

- MAGC1_HUMAN

UniProt

O60732 - MAGC1_HUMAN

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Protein

Melanoma-associated antigen C1

Gene

MAGEC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Keywords - Molecular functioni

Tumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen C1
Alternative name(s):
Cancer/testis antigen 7.1
Short name:
CT7.1
MAGE-C1 antigen
Gene namesi
Name:MAGEC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:6812. MAGEC1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30558.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11421142Melanoma-associated antigen C1PRO_0000156720Add
BLAST

Proteomic databases

MaxQBiO60732.
PaxDbiO60732.
PRIDEiO60732.

PTM databases

PhosphoSiteiO60732.

Expressioni

Tissue specificityi

Expressed in testis and in tumors of a wide variety of histologic types.

Gene expression databases

BgeeiO60732.
CleanExiHS_MAGEC1.
ExpressionAtlasiO60732. baseline and differential.
GenevestigatoriO60732.

Organism-specific databases

HPAiCAB015452.
HPA004622.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CTAG1BP783586EBI-1188463,EBI-1188472

Protein-protein interaction databases

BioGridi115272. 10 interactions.
IntActiO60732. 7 interactions.
STRINGi9606.ENSP00000285879.

Structurei

3D structure databases

ProteinModelPortaliO60732.
SMRiO60732. Positions 898-1107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini908 – 1106199MAGEPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MAGE domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4562.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000113459.
InParanoidiO60732.
OMAiSLSPHYF.
OrthoDBiEOG75F4GM.
PhylomeDBiO60732.
TreeFamiTF328505.

Family and domain databases

InterProiIPR002190. MAGE.
[Graphical view]
PANTHERiPTHR11736. PTHR11736. 1 hit.
PfamiPF01454. MAGE. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O60732-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDKDMPTAG MPSLLQSSSE SPQSCPEGED SQSPLQIPQS SPESDDTLYP
60 70 80 90 100
LQSPQSRSEG EDSSDPLQRP PEGKDSQSPL QIPQSSPEGD DTQSPLQNSQ
110 120 130 140 150
SSPEGKDSLS PLEISQSPPE GEDVQSPLQN PASSFFSSAL LSIFQSSPES
160 170 180 190 200
TQSPFEGFPQ SVLQIPVSAA SSSTLVSIFQ SSPESTQSPF EGFPQSPLQI
210 220 230 240 250
PVSRSFSSTL LSIFQSSPER TQSTFEGFAQ SPLQIPVSPS SSSTLLSLFQ
260 270 280 290 300
SFSERTQSTF EGFAQSSLQI PVSPSFSSTL VSLFQSSPER TQSTFEGFPQ
310 320 330 340 350
SPLQIPVSSS SSSTLLSLFQ SSPERTHSTF EGFPQSLLQI PMTSSFSSTL
360 370 380 390 400
LSIFQSSPES AQSTFEGFPQ SPLQIPGSPS FSSTLLSLFQ SSPERTHSTF
410 420 430 440 450
EGFPQSPLQI PMTSSFSSTL LSILQSSPES AQSAFEGFPQ SPLQIPVSSS
460 470 480 490 500
FSYTLLSLFQ SSPERTHSTF EGFPQSPLQI PVSSSSSSST LLSLFQSSPE
510 520 530 540 550
CTQSTFEGFP QSPLQIPQSP PEGENTHSPL QIVPSLPEWE DSLSPHYFPQ
560 570 580 590 600
SPPQGEDSLS PHYFPQSPPQ GEDSLSPHYF PQSPQGEDSL SPHYFPQSPP
610 620 630 640 650
QGEDSMSPLY FPQSPLQGEE FQSSLQSPVS ICSSSTPSSL PQSFPESSQS
660 670 680 690 700
PPEGPVQSPL HSPQSPPEGM HSQSPLQSPE SAPEGEDSLS PLQIPQSPLE
710 720 730 740 750
GEDSLSSLHF PQSPPEWEDS LSPLHFPQFP PQGEDFQSSL QSPVSICSSS
760 770 780 790 800
TSLSLPQSFP ESPQSPPEGP AQSPLQRPVS SFFSYTLASL LQSSHESPQS
810 820 830 840 850
PPEGPAQSPL QSPVSSFPSS TSSSLSQSSP VSSFPSSTSS SLSKSSPESP
860 870 880 890 900
LQSPVISFSS STSLSPFSEE SSSPVDEYTS SSDTLLESDS LTDSESLIES
910 920 930 940 950
EPLFTYTLDE KVDELARFLL LKYQVKQPIT KAEMLTNVIS RYTGYFPVIF
960 970 980 990 1000
RKAREFIEIL FGISLREVDP DDSYVFVNTL DLTSEGCLSD EQGMSQNRLL
1010 1020 1030 1040 1050
ILILSIIFIK GTYASEEVIW DVLSGIGVRA GREHFAFGEP RELLTKVWVQ
1060 1070 1080 1090 1100
EHYLEYREVP NSSPPRYEFL WGPRAHSEVI KRKVVEFLAM LKNTVPITFP
1110 1120 1130 1140
SSYKDALKDV EERAQAIIDT TDDSTATESA SSSVMSPSFS SE
Length:1,142
Mass (Da):123,643
Last modified:June 27, 2006 - v3
Checksum:i6C9AE820156F3C50
GO
Isoform 2 (identifier: O60732-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-933: Missing.

Note: No experimental confirmation available.

Show »
Length:209
Mass (Da):23,747
Checksum:i402F6EAF6A78C72B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti221 – 2255TQSTF → SQRTS(PubMed:9485030)Curated
Sequence conflicti221 – 2255TQSTF → SQRTS(PubMed:9618514)Curated
Sequence conflicti239 – 2391P → S(PubMed:9485030)Curated
Sequence conflicti239 – 2391P → S(PubMed:9618514)Curated
Sequence conflicti252 – 2532FS → SP(PubMed:9485030)Curated
Sequence conflicti252 – 2532FS → SP(PubMed:9618514)Curated
Sequence conflicti264 – 2641A → P(PubMed:9485030)Curated
Sequence conflicti264 – 2641A → P(PubMed:9618514)Curated
Sequence conflicti267 – 2671S → P(PubMed:9485030)Curated
Sequence conflicti267 – 2671S → P(PubMed:9618514)Curated
Sequence conflicti274 – 2741P → R(PubMed:9485030)Curated
Sequence conflicti274 – 2741P → R(PubMed:9618514)Curated
Sequence conflicti281 – 2833VSL → LSI(PubMed:9485030)Curated
Sequence conflicti281 – 2833VSL → LSI(PubMed:9618514)Curated
Sequence conflicti299 – 2991P → A(PubMed:9485030)Curated
Sequence conflicti299 – 2991P → A(PubMed:9618514)Curated
Sequence conflicti309 – 3113SSS → PSF in AAC24227. (PubMed:9618514)Curated
Sequence conflicti316 – 3183LSL → VSI in AAC24227. (PubMed:9618514)Curated
Sequence conflicti337 – 3371L → P in AAC24227. (PubMed:9618514)Curated
Sequence conflicti342 – 3432MT → VS in AAC24227. (PubMed:9618514)Curated
Sequence conflicti353 – 3531I → L in AAC24227. (PubMed:9618514)Curated
Sequence conflicti360 – 3612SA → RT in AAC24227. (PubMed:9618514)Curated
Sequence conflicti467 – 4671H → Q in AAC18837. (PubMed:9485030)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti25 – 251C → Y.1 Publication
Corresponds to variant rs176036 [ dbSNP | Ensembl ].
VAR_053501
Natural varianti151 – 1511T → I.2 Publications
Corresponds to variant rs176037 [ dbSNP | Ensembl ].
VAR_053502
Natural varianti257 – 2571Q → H.
Corresponds to variant rs176047 [ dbSNP | Ensembl ].
VAR_053503
Natural varianti276 – 2761F → S.
Corresponds to variant rs1055491 [ dbSNP | Ensembl ].
VAR_053504
Natural varianti327 – 3271H → Q.2 Publications
Corresponds to variant rs176047 [ dbSNP | Ensembl ].
VAR_060068
Natural varianti709 – 7091H → Y.
Corresponds to variant rs56256227 [ dbSNP | Ensembl ].
VAR_062121

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 933933Missing in isoform 2. 1 PublicationVSP_056382Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF064589 Genomic DNA. Translation: AAC18837.1.
AF056334 mRNA. Translation: AAC24227.1.
AL022152 Genomic DNA. Translation: CAD27434.1.
BC127771 mRNA. Translation: AAI27772.1.
CCDSiCCDS35417.1. [O60732-1]
RefSeqiNP_005453.2. NM_005462.4.
UniGeneiHs.132194.

Genome annotation databases

EnsembliENST00000285879; ENSP00000285879; ENSG00000155495. [O60732-1]
ENST00000406005; ENSP00000385500; ENSG00000155495. [O60732-2]
GeneIDi9947.
KEGGihsa:9947.
UCSCiuc004fbt.3. human. [O60732-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF064589 Genomic DNA. Translation: AAC18837.1 .
AF056334 mRNA. Translation: AAC24227.1 .
AL022152 Genomic DNA. Translation: CAD27434.1 .
BC127771 mRNA. Translation: AAI27772.1 .
CCDSi CCDS35417.1. [O60732-1 ]
RefSeqi NP_005453.2. NM_005462.4.
UniGenei Hs.132194.

3D structure databases

ProteinModelPortali O60732.
SMRi O60732. Positions 898-1107.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115272. 10 interactions.
IntActi O60732. 7 interactions.
STRINGi 9606.ENSP00000285879.

PTM databases

PhosphoSitei O60732.

Proteomic databases

MaxQBi O60732.
PaxDbi O60732.
PRIDEi O60732.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000285879 ; ENSP00000285879 ; ENSG00000155495 . [O60732-1 ]
ENST00000406005 ; ENSP00000385500 ; ENSG00000155495 . [O60732-2 ]
GeneIDi 9947.
KEGGi hsa:9947.
UCSCi uc004fbt.3. human. [O60732-1 ]

Organism-specific databases

CTDi 9947.
GeneCardsi GC0XP140991.
H-InvDB HIX0203313.
HGNCi HGNC:6812. MAGEC1.
HPAi CAB015452.
HPA004622.
MIMi 300223. gene.
neXtProti NX_O60732.
PharmGKBi PA30558.
GenAtlasi Search...

Phylogenomic databases

eggNOGi KOG4562.
GeneTreei ENSGT00760000118824.
HOGENOMi HOG000113459.
InParanoidi O60732.
OMAi SLSPHYF.
OrthoDBi EOG75F4GM.
PhylomeDBi O60732.
TreeFami TF328505.

Miscellaneous databases

GenomeRNAii 9947.
NextBioi 35460190.
PROi O60732.
SOURCEi Search...

Gene expression databases

Bgeei O60732.
CleanExi HS_MAGEC1.
ExpressionAtlasi O60732. baseline and differential.
Genevestigatori O60732.

Family and domain databases

InterProi IPR002190. MAGE.
[Graphical view ]
PANTHERi PTHR11736. PTHR11736. 1 hit.
Pfami PF01454. MAGE. 1 hit.
[Graphical view ]
PROSITEi PS50838. MAGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a new MAGE gene with tumor-specific expression by representational difference analysis."
    Lucas S., De Smet C., Arden K.C., Viars C.S., Lethe B.G., Lurquin C., Boon T.
    Cancer Res. 58:743-752(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS TYR-25; ILE-151 AND GLN-327.
    Tissue: Melanoma.
  2. "Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library."
    Chen Y.-T., Gure A.O., Tsang S., Stockert E., Jager E., Knuth A., Old L.J.
    Proc. Natl. Acad. Sci. U.S.A. 95:6919-6923(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ILE-151 AND GLN-327.
    Tissue: Melanoma.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMAGC1_HUMAN
AccessioniPrimary (citable) accession number: O60732
Secondary accession number(s): A0PK03, O75451, Q8TCV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 27, 2006
Last modified: October 29, 2014
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3