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O60732

- MAGC1_HUMAN

UniProt

O60732 - MAGC1_HUMAN

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Protein
Melanoma-associated antigen C1
Gene
MAGEC1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

Keywords - Molecular functioni

Tumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen C1
Alternative name(s):
Cancer/testis antigen 7.1
Short name:
CT7.1
MAGE-C1 antigen
Gene namesi
Name:MAGEC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:6812. MAGEC1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30558.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11421142Melanoma-associated antigen C1
PRO_0000156720Add
BLAST

Proteomic databases

MaxQBiO60732.
PaxDbiO60732.
PRIDEiO60732.

PTM databases

PhosphoSiteiO60732.

Expressioni

Tissue specificityi

Expressed in testis and in tumors of a wide variety of histologic types.

Gene expression databases

ArrayExpressiO60732.
BgeeiO60732.
CleanExiHS_MAGEC1.
GenevestigatoriO60732.

Organism-specific databases

HPAiCAB015452.
HPA004622.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CTAG1BP783586EBI-1188463,EBI-1188472

Protein-protein interaction databases

BioGridi115272. 10 interactions.
IntActiO60732. 7 interactions.
STRINGi9606.ENSP00000285879.

Structurei

3D structure databases

ProteinModelPortaliO60732.
SMRiO60732. Positions 898-1107.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini908 – 1106199MAGE
Add
BLAST

Sequence similaritiesi

Contains 1 MAGE domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4562.
HOGENOMiHOG000113459.
InParanoidiO60732.
OMAiSLSPHYF.
OrthoDBiEOG75F4GM.
PhylomeDBiO60732.
TreeFamiTF328505.

Family and domain databases

InterProiIPR002190. MAGE.
[Graphical view]
PANTHERiPTHR11736. PTHR11736. 1 hit.
PfamiPF01454. MAGE. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60732-1 [UniParc]FASTAAdd to Basket

« Hide

MGDKDMPTAG MPSLLQSSSE SPQSCPEGED SQSPLQIPQS SPESDDTLYP     50
LQSPQSRSEG EDSSDPLQRP PEGKDSQSPL QIPQSSPEGD DTQSPLQNSQ 100
SSPEGKDSLS PLEISQSPPE GEDVQSPLQN PASSFFSSAL LSIFQSSPES 150
TQSPFEGFPQ SVLQIPVSAA SSSTLVSIFQ SSPESTQSPF EGFPQSPLQI 200
PVSRSFSSTL LSIFQSSPER TQSTFEGFAQ SPLQIPVSPS SSSTLLSLFQ 250
SFSERTQSTF EGFAQSSLQI PVSPSFSSTL VSLFQSSPER TQSTFEGFPQ 300
SPLQIPVSSS SSSTLLSLFQ SSPERTHSTF EGFPQSLLQI PMTSSFSSTL 350
LSIFQSSPES AQSTFEGFPQ SPLQIPGSPS FSSTLLSLFQ SSPERTHSTF 400
EGFPQSPLQI PMTSSFSSTL LSILQSSPES AQSAFEGFPQ SPLQIPVSSS 450
FSYTLLSLFQ SSPERTHSTF EGFPQSPLQI PVSSSSSSST LLSLFQSSPE 500
CTQSTFEGFP QSPLQIPQSP PEGENTHSPL QIVPSLPEWE DSLSPHYFPQ 550
SPPQGEDSLS PHYFPQSPPQ GEDSLSPHYF PQSPQGEDSL SPHYFPQSPP 600
QGEDSMSPLY FPQSPLQGEE FQSSLQSPVS ICSSSTPSSL PQSFPESSQS 650
PPEGPVQSPL HSPQSPPEGM HSQSPLQSPE SAPEGEDSLS PLQIPQSPLE 700
GEDSLSSLHF PQSPPEWEDS LSPLHFPQFP PQGEDFQSSL QSPVSICSSS 750
TSLSLPQSFP ESPQSPPEGP AQSPLQRPVS SFFSYTLASL LQSSHESPQS 800
PPEGPAQSPL QSPVSSFPSS TSSSLSQSSP VSSFPSSTSS SLSKSSPESP 850
LQSPVISFSS STSLSPFSEE SSSPVDEYTS SSDTLLESDS LTDSESLIES 900
EPLFTYTLDE KVDELARFLL LKYQVKQPIT KAEMLTNVIS RYTGYFPVIF 950
RKAREFIEIL FGISLREVDP DDSYVFVNTL DLTSEGCLSD EQGMSQNRLL 1000
ILILSIIFIK GTYASEEVIW DVLSGIGVRA GREHFAFGEP RELLTKVWVQ 1050
EHYLEYREVP NSSPPRYEFL WGPRAHSEVI KRKVVEFLAM LKNTVPITFP 1100
SSYKDALKDV EERAQAIIDT TDDSTATESA SSSVMSPSFS SE 1142
Length:1,142
Mass (Da):123,643
Last modified:June 27, 2006 - v3
Checksum:i6C9AE820156F3C50
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti25 – 251C → Y.1 Publication
Corresponds to variant rs176036 [ dbSNP | Ensembl ].
VAR_053501
Natural varianti151 – 1511T → I.2 Publications
Corresponds to variant rs176037 [ dbSNP | Ensembl ].
VAR_053502
Natural varianti257 – 2571Q → H.
Corresponds to variant rs176047 [ dbSNP | Ensembl ].
VAR_053503
Natural varianti276 – 2761F → S.
Corresponds to variant rs1055491 [ dbSNP | Ensembl ].
VAR_053504
Natural varianti327 – 3271H → Q.2 Publications
Corresponds to variant rs176047 [ dbSNP | Ensembl ].
VAR_060068
Natural varianti709 – 7091H → Y.
Corresponds to variant rs56256227 [ dbSNP | Ensembl ].
VAR_062121

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti221 – 2255TQSTF → SQRTS1 Publication
Sequence conflicti221 – 2255TQSTF → SQRTS1 Publication
Sequence conflicti239 – 2391P → S1 Publication
Sequence conflicti239 – 2391P → S1 Publication
Sequence conflicti252 – 2532FS → SP1 Publication
Sequence conflicti252 – 2532FS → SP1 Publication
Sequence conflicti264 – 2641A → P1 Publication
Sequence conflicti264 – 2641A → P1 Publication
Sequence conflicti267 – 2671S → P1 Publication
Sequence conflicti267 – 2671S → P1 Publication
Sequence conflicti274 – 2741P → R1 Publication
Sequence conflicti274 – 2741P → R1 Publication
Sequence conflicti281 – 2833VSL → LSI1 Publication
Sequence conflicti281 – 2833VSL → LSI1 Publication
Sequence conflicti299 – 2991P → A1 Publication
Sequence conflicti299 – 2991P → A1 Publication
Sequence conflicti309 – 3113SSS → PSF in AAC24227. 1 Publication
Sequence conflicti316 – 3183LSL → VSI in AAC24227. 1 Publication
Sequence conflicti337 – 3371L → P in AAC24227. 1 Publication
Sequence conflicti342 – 3432MT → VS in AAC24227. 1 Publication
Sequence conflicti353 – 3531I → L in AAC24227. 1 Publication
Sequence conflicti360 – 3612SA → RT in AAC24227. 1 Publication
Sequence conflicti467 – 4671H → Q in AAC18837. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF064589 Genomic DNA. Translation: AAC18837.1.
AF056334 mRNA. Translation: AAC24227.1.
AL022152 Genomic DNA. Translation: CAD27434.1.
CCDSiCCDS35417.1.
RefSeqiNP_005453.2. NM_005462.4.
UniGeneiHs.132194.

Genome annotation databases

EnsembliENST00000285879; ENSP00000285879; ENSG00000155495.
GeneIDi9947.
KEGGihsa:9947.
UCSCiuc004fbt.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF064589 Genomic DNA. Translation: AAC18837.1 .
AF056334 mRNA. Translation: AAC24227.1 .
AL022152 Genomic DNA. Translation: CAD27434.1 .
CCDSi CCDS35417.1.
RefSeqi NP_005453.2. NM_005462.4.
UniGenei Hs.132194.

3D structure databases

ProteinModelPortali O60732.
SMRi O60732. Positions 898-1107.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115272. 10 interactions.
IntActi O60732. 7 interactions.
STRINGi 9606.ENSP00000285879.

PTM databases

PhosphoSitei O60732.

Proteomic databases

MaxQBi O60732.
PaxDbi O60732.
PRIDEi O60732.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000285879 ; ENSP00000285879 ; ENSG00000155495 .
GeneIDi 9947.
KEGGi hsa:9947.
UCSCi uc004fbt.3. human.

Organism-specific databases

CTDi 9947.
GeneCardsi GC0XP140991.
H-InvDB HIX0203313.
HGNCi HGNC:6812. MAGEC1.
HPAi CAB015452.
HPA004622.
MIMi 300223. gene.
neXtProti NX_O60732.
PharmGKBi PA30558.
GenAtlasi Search...

Phylogenomic databases

eggNOGi KOG4562.
HOGENOMi HOG000113459.
InParanoidi O60732.
OMAi SLSPHYF.
OrthoDBi EOG75F4GM.
PhylomeDBi O60732.
TreeFami TF328505.

Miscellaneous databases

GenomeRNAii 9947.
NextBioi 37528.
PROi O60732.
SOURCEi Search...

Gene expression databases

ArrayExpressi O60732.
Bgeei O60732.
CleanExi HS_MAGEC1.
Genevestigatori O60732.

Family and domain databases

InterProi IPR002190. MAGE.
[Graphical view ]
PANTHERi PTHR11736. PTHR11736. 1 hit.
Pfami PF01454. MAGE. 1 hit.
[Graphical view ]
PROSITEi PS50838. MAGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a new MAGE gene with tumor-specific expression by representational difference analysis."
    Lucas S., De Smet C., Arden K.C., Viars C.S., Lethe B.G., Lurquin C., Boon T.
    Cancer Res. 58:743-752(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS TYR-25; ILE-151 AND GLN-327.
    Tissue: Melanoma.
  2. "Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library."
    Chen Y.-T., Gure A.O., Tsang S., Stockert E., Jager E., Knuth A., Old L.J.
    Proc. Natl. Acad. Sci. U.S.A. 95:6919-6923(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ILE-151 AND GLN-327.
    Tissue: Melanoma.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMAGC1_HUMAN
AccessioniPrimary (citable) accession number: O60732
Secondary accession number(s): O75451, Q8TCV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 27, 2006
Last modified: July 9, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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