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O60732

- MAGC1_HUMAN

UniProt

O60732 - MAGC1_HUMAN

Protein

Melanoma-associated antigen C1

Gene

MAGEC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 3 (27 Jun 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Keywords - Molecular functioni

    Tumor antigen

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Melanoma-associated antigen C1
    Alternative name(s):
    Cancer/testis antigen 7.1
    Short name:
    CT7.1
    MAGE-C1 antigen
    Gene namesi
    Name:MAGEC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:6812. MAGEC1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30558.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11421142Melanoma-associated antigen C1PRO_0000156720Add
    BLAST

    Proteomic databases

    MaxQBiO60732.
    PaxDbiO60732.
    PRIDEiO60732.

    PTM databases

    PhosphoSiteiO60732.

    Expressioni

    Tissue specificityi

    Expressed in testis and in tumors of a wide variety of histologic types.

    Gene expression databases

    ArrayExpressiO60732.
    BgeeiO60732.
    CleanExiHS_MAGEC1.
    GenevestigatoriO60732.

    Organism-specific databases

    HPAiCAB015452.
    HPA004622.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CTAG1BP783586EBI-1188463,EBI-1188472

    Protein-protein interaction databases

    BioGridi115272. 10 interactions.
    IntActiO60732. 7 interactions.
    STRINGi9606.ENSP00000285879.

    Structurei

    3D structure databases

    ProteinModelPortaliO60732.
    SMRiO60732. Positions 898-1107.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini908 – 1106199MAGEPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 MAGE domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiKOG4562.
    HOGENOMiHOG000113459.
    InParanoidiO60732.
    OMAiSLSPHYF.
    OrthoDBiEOG75F4GM.
    PhylomeDBiO60732.
    TreeFamiTF328505.

    Family and domain databases

    InterProiIPR002190. MAGE.
    [Graphical view]
    PANTHERiPTHR11736. PTHR11736. 1 hit.
    PfamiPF01454. MAGE. 1 hit.
    [Graphical view]
    PROSITEiPS50838. MAGE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O60732-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGDKDMPTAG MPSLLQSSSE SPQSCPEGED SQSPLQIPQS SPESDDTLYP     50
    LQSPQSRSEG EDSSDPLQRP PEGKDSQSPL QIPQSSPEGD DTQSPLQNSQ 100
    SSPEGKDSLS PLEISQSPPE GEDVQSPLQN PASSFFSSAL LSIFQSSPES 150
    TQSPFEGFPQ SVLQIPVSAA SSSTLVSIFQ SSPESTQSPF EGFPQSPLQI 200
    PVSRSFSSTL LSIFQSSPER TQSTFEGFAQ SPLQIPVSPS SSSTLLSLFQ 250
    SFSERTQSTF EGFAQSSLQI PVSPSFSSTL VSLFQSSPER TQSTFEGFPQ 300
    SPLQIPVSSS SSSTLLSLFQ SSPERTHSTF EGFPQSLLQI PMTSSFSSTL 350
    LSIFQSSPES AQSTFEGFPQ SPLQIPGSPS FSSTLLSLFQ SSPERTHSTF 400
    EGFPQSPLQI PMTSSFSSTL LSILQSSPES AQSAFEGFPQ SPLQIPVSSS 450
    FSYTLLSLFQ SSPERTHSTF EGFPQSPLQI PVSSSSSSST LLSLFQSSPE 500
    CTQSTFEGFP QSPLQIPQSP PEGENTHSPL QIVPSLPEWE DSLSPHYFPQ 550
    SPPQGEDSLS PHYFPQSPPQ GEDSLSPHYF PQSPQGEDSL SPHYFPQSPP 600
    QGEDSMSPLY FPQSPLQGEE FQSSLQSPVS ICSSSTPSSL PQSFPESSQS 650
    PPEGPVQSPL HSPQSPPEGM HSQSPLQSPE SAPEGEDSLS PLQIPQSPLE 700
    GEDSLSSLHF PQSPPEWEDS LSPLHFPQFP PQGEDFQSSL QSPVSICSSS 750
    TSLSLPQSFP ESPQSPPEGP AQSPLQRPVS SFFSYTLASL LQSSHESPQS 800
    PPEGPAQSPL QSPVSSFPSS TSSSLSQSSP VSSFPSSTSS SLSKSSPESP 850
    LQSPVISFSS STSLSPFSEE SSSPVDEYTS SSDTLLESDS LTDSESLIES 900
    EPLFTYTLDE KVDELARFLL LKYQVKQPIT KAEMLTNVIS RYTGYFPVIF 950
    RKAREFIEIL FGISLREVDP DDSYVFVNTL DLTSEGCLSD EQGMSQNRLL 1000
    ILILSIIFIK GTYASEEVIW DVLSGIGVRA GREHFAFGEP RELLTKVWVQ 1050
    EHYLEYREVP NSSPPRYEFL WGPRAHSEVI KRKVVEFLAM LKNTVPITFP 1100
    SSYKDALKDV EERAQAIIDT TDDSTATESA SSSVMSPSFS SE 1142
    Length:1,142
    Mass (Da):123,643
    Last modified:June 27, 2006 - v3
    Checksum:i6C9AE820156F3C50
    GO
    Isoform 2 (identifier: O60732-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-933: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:209
    Mass (Da):23,747
    Checksum:i402F6EAF6A78C72B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti221 – 2255TQSTF → SQRTS(PubMed:9485030)Curated
    Sequence conflicti221 – 2255TQSTF → SQRTS(PubMed:9618514)Curated
    Sequence conflicti239 – 2391P → S(PubMed:9485030)Curated
    Sequence conflicti239 – 2391P → S(PubMed:9618514)Curated
    Sequence conflicti252 – 2532FS → SP(PubMed:9485030)Curated
    Sequence conflicti252 – 2532FS → SP(PubMed:9618514)Curated
    Sequence conflicti264 – 2641A → P(PubMed:9485030)Curated
    Sequence conflicti264 – 2641A → P(PubMed:9618514)Curated
    Sequence conflicti267 – 2671S → P(PubMed:9485030)Curated
    Sequence conflicti267 – 2671S → P(PubMed:9618514)Curated
    Sequence conflicti274 – 2741P → R(PubMed:9485030)Curated
    Sequence conflicti274 – 2741P → R(PubMed:9618514)Curated
    Sequence conflicti281 – 2833VSL → LSI(PubMed:9485030)Curated
    Sequence conflicti281 – 2833VSL → LSI(PubMed:9618514)Curated
    Sequence conflicti299 – 2991P → A(PubMed:9485030)Curated
    Sequence conflicti299 – 2991P → A(PubMed:9618514)Curated
    Sequence conflicti309 – 3113SSS → PSF in AAC24227. (PubMed:9618514)Curated
    Sequence conflicti316 – 3183LSL → VSI in AAC24227. (PubMed:9618514)Curated
    Sequence conflicti337 – 3371L → P in AAC24227. (PubMed:9618514)Curated
    Sequence conflicti342 – 3432MT → VS in AAC24227. (PubMed:9618514)Curated
    Sequence conflicti353 – 3531I → L in AAC24227. (PubMed:9618514)Curated
    Sequence conflicti360 – 3612SA → RT in AAC24227. (PubMed:9618514)Curated
    Sequence conflicti467 – 4671H → Q in AAC18837. (PubMed:9485030)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti25 – 251C → Y.1 Publication
    Corresponds to variant rs176036 [ dbSNP | Ensembl ].
    VAR_053501
    Natural varianti151 – 1511T → I.2 Publications
    Corresponds to variant rs176037 [ dbSNP | Ensembl ].
    VAR_053502
    Natural varianti257 – 2571Q → H.
    Corresponds to variant rs176047 [ dbSNP | Ensembl ].
    VAR_053503
    Natural varianti276 – 2761F → S.
    Corresponds to variant rs1055491 [ dbSNP | Ensembl ].
    VAR_053504
    Natural varianti327 – 3271H → Q.2 Publications
    Corresponds to variant rs176047 [ dbSNP | Ensembl ].
    VAR_060068
    Natural varianti709 – 7091H → Y.
    Corresponds to variant rs56256227 [ dbSNP | Ensembl ].
    VAR_062121

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 933933Missing in isoform 2. 1 PublicationVSP_056382Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF064589 Genomic DNA. Translation: AAC18837.1.
    AF056334 mRNA. Translation: AAC24227.1.
    AL022152 Genomic DNA. Translation: CAD27434.1.
    BC127771 mRNA. Translation: AAI27772.1.
    CCDSiCCDS35417.1.
    RefSeqiNP_005453.2. NM_005462.4.
    UniGeneiHs.132194.

    Genome annotation databases

    EnsembliENST00000285879; ENSP00000285879; ENSG00000155495.
    ENST00000406005; ENSP00000385500; ENSG00000155495.
    GeneIDi9947.
    KEGGihsa:9947.
    UCSCiuc004fbt.3. human.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF064589 Genomic DNA. Translation: AAC18837.1 .
    AF056334 mRNA. Translation: AAC24227.1 .
    AL022152 Genomic DNA. Translation: CAD27434.1 .
    BC127771 mRNA. Translation: AAI27772.1 .
    CCDSi CCDS35417.1.
    RefSeqi NP_005453.2. NM_005462.4.
    UniGenei Hs.132194.

    3D structure databases

    ProteinModelPortali O60732.
    SMRi O60732. Positions 898-1107.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115272. 10 interactions.
    IntActi O60732. 7 interactions.
    STRINGi 9606.ENSP00000285879.

    PTM databases

    PhosphoSitei O60732.

    Proteomic databases

    MaxQBi O60732.
    PaxDbi O60732.
    PRIDEi O60732.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000285879 ; ENSP00000285879 ; ENSG00000155495 .
    ENST00000406005 ; ENSP00000385500 ; ENSG00000155495 .
    GeneIDi 9947.
    KEGGi hsa:9947.
    UCSCi uc004fbt.3. human.

    Organism-specific databases

    CTDi 9947.
    GeneCardsi GC0XP140991.
    H-InvDB HIX0203313.
    HGNCi HGNC:6812. MAGEC1.
    HPAi CAB015452.
    HPA004622.
    MIMi 300223. gene.
    neXtProti NX_O60732.
    PharmGKBi PA30558.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi KOG4562.
    HOGENOMi HOG000113459.
    InParanoidi O60732.
    OMAi SLSPHYF.
    OrthoDBi EOG75F4GM.
    PhylomeDBi O60732.
    TreeFami TF328505.

    Miscellaneous databases

    GenomeRNAii 9947.
    NextBioi 37528.
    PROi O60732.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60732.
    Bgeei O60732.
    CleanExi HS_MAGEC1.
    Genevestigatori O60732.

    Family and domain databases

    InterProi IPR002190. MAGE.
    [Graphical view ]
    PANTHERi PTHR11736. PTHR11736. 1 hit.
    Pfami PF01454. MAGE. 1 hit.
    [Graphical view ]
    PROSITEi PS50838. MAGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a new MAGE gene with tumor-specific expression by representational difference analysis."
      Lucas S., De Smet C., Arden K.C., Viars C.S., Lethe B.G., Lurquin C., Boon T.
      Cancer Res. 58:743-752(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS TYR-25; ILE-151 AND GLN-327.
      Tissue: Melanoma.
    2. "Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library."
      Chen Y.-T., Gure A.O., Tsang S., Stockert E., Jager E., Knuth A., Old L.J.
      Proc. Natl. Acad. Sci. U.S.A. 95:6919-6923(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ILE-151 AND GLN-327.
      Tissue: Melanoma.
    3. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMAGC1_HUMAN
    AccessioniPrimary (citable) accession number: O60732
    Secondary accession number(s): A0PK03, O75451, Q8TCV4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 103 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3