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O60732 (MAGC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Melanoma-associated antigen C1
Alternative name(s):
Cancer/testis antigen 7.1
Short name=CT7.1
MAGE-C1 antigen
Gene names
Name:MAGEC1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1142 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Tissue specificity

Expressed in testis and in tumors of a wide variety of histologic types.

Sequence similarities

Contains 1 MAGE domain.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainRepeat
   Molecular functionTumor antigen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionprotein binding

Inferred from physical interaction PubMed 17137291. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CTAG1BP783586EBI-1188463,EBI-1188472

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11421142Melanoma-associated antigen C1
PRO_0000156720

Regions

Domain908 – 1106199MAGE

Natural variations

Natural variant251C → Y. Ref.1
Corresponds to variant rs176036 [ dbSNP | Ensembl ].
VAR_053501
Natural variant1511T → I. Ref.1 Ref.2
Corresponds to variant rs176037 [ dbSNP | Ensembl ].
VAR_053502
Natural variant2571Q → H.
Corresponds to variant rs176047 [ dbSNP | Ensembl ].
VAR_053503
Natural variant2761F → S.
Corresponds to variant rs1055491 [ dbSNP | Ensembl ].
VAR_053504
Natural variant3271H → Q. Ref.1 Ref.2
Corresponds to variant rs176047 [ dbSNP | Ensembl ].
VAR_060068
Natural variant7091H → Y.
Corresponds to variant rs56256227 [ dbSNP | Ensembl ].
VAR_062121

Experimental info

Sequence conflict221 – 2255TQSTF → SQRTS Ref.1
Sequence conflict221 – 2255TQSTF → SQRTS Ref.2
Sequence conflict2391P → S Ref.1
Sequence conflict2391P → S Ref.2
Sequence conflict252 – 2532FS → SP Ref.1
Sequence conflict252 – 2532FS → SP Ref.2
Sequence conflict2641A → P Ref.1
Sequence conflict2641A → P Ref.2
Sequence conflict2671S → P Ref.1
Sequence conflict2671S → P Ref.2
Sequence conflict2741P → R Ref.1
Sequence conflict2741P → R Ref.2
Sequence conflict281 – 2833VSL → LSI Ref.1
Sequence conflict281 – 2833VSL → LSI Ref.2
Sequence conflict2991P → A Ref.1
Sequence conflict2991P → A Ref.2
Sequence conflict309 – 3113SSS → PSF in AAC24227. Ref.2
Sequence conflict316 – 3183LSL → VSI in AAC24227. Ref.2
Sequence conflict3371L → P in AAC24227. Ref.2
Sequence conflict342 – 3432MT → VS in AAC24227. Ref.2
Sequence conflict3531I → L in AAC24227. Ref.2
Sequence conflict360 – 3612SA → RT in AAC24227. Ref.2
Sequence conflict4671H → Q in AAC18837. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O60732 [UniParc].

Last modified June 27, 2006. Version 3.
Checksum: 6C9AE820156F3C50

FASTA1,142123,643
        10         20         30         40         50         60 
MGDKDMPTAG MPSLLQSSSE SPQSCPEGED SQSPLQIPQS SPESDDTLYP LQSPQSRSEG 

        70         80         90        100        110        120 
EDSSDPLQRP PEGKDSQSPL QIPQSSPEGD DTQSPLQNSQ SSPEGKDSLS PLEISQSPPE 

       130        140        150        160        170        180 
GEDVQSPLQN PASSFFSSAL LSIFQSSPES TQSPFEGFPQ SVLQIPVSAA SSSTLVSIFQ 

       190        200        210        220        230        240 
SSPESTQSPF EGFPQSPLQI PVSRSFSSTL LSIFQSSPER TQSTFEGFAQ SPLQIPVSPS 

       250        260        270        280        290        300 
SSSTLLSLFQ SFSERTQSTF EGFAQSSLQI PVSPSFSSTL VSLFQSSPER TQSTFEGFPQ 

       310        320        330        340        350        360 
SPLQIPVSSS SSSTLLSLFQ SSPERTHSTF EGFPQSLLQI PMTSSFSSTL LSIFQSSPES 

       370        380        390        400        410        420 
AQSTFEGFPQ SPLQIPGSPS FSSTLLSLFQ SSPERTHSTF EGFPQSPLQI PMTSSFSSTL 

       430        440        450        460        470        480 
LSILQSSPES AQSAFEGFPQ SPLQIPVSSS FSYTLLSLFQ SSPERTHSTF EGFPQSPLQI 

       490        500        510        520        530        540 
PVSSSSSSST LLSLFQSSPE CTQSTFEGFP QSPLQIPQSP PEGENTHSPL QIVPSLPEWE 

       550        560        570        580        590        600 
DSLSPHYFPQ SPPQGEDSLS PHYFPQSPPQ GEDSLSPHYF PQSPQGEDSL SPHYFPQSPP 

       610        620        630        640        650        660 
QGEDSMSPLY FPQSPLQGEE FQSSLQSPVS ICSSSTPSSL PQSFPESSQS PPEGPVQSPL 

       670        680        690        700        710        720 
HSPQSPPEGM HSQSPLQSPE SAPEGEDSLS PLQIPQSPLE GEDSLSSLHF PQSPPEWEDS 

       730        740        750        760        770        780 
LSPLHFPQFP PQGEDFQSSL QSPVSICSSS TSLSLPQSFP ESPQSPPEGP AQSPLQRPVS 

       790        800        810        820        830        840 
SFFSYTLASL LQSSHESPQS PPEGPAQSPL QSPVSSFPSS TSSSLSQSSP VSSFPSSTSS 

       850        860        870        880        890        900 
SLSKSSPESP LQSPVISFSS STSLSPFSEE SSSPVDEYTS SSDTLLESDS LTDSESLIES 

       910        920        930        940        950        960 
EPLFTYTLDE KVDELARFLL LKYQVKQPIT KAEMLTNVIS RYTGYFPVIF RKAREFIEIL 

       970        980        990       1000       1010       1020 
FGISLREVDP DDSYVFVNTL DLTSEGCLSD EQGMSQNRLL ILILSIIFIK GTYASEEVIW 

      1030       1040       1050       1060       1070       1080 
DVLSGIGVRA GREHFAFGEP RELLTKVWVQ EHYLEYREVP NSSPPRYEFL WGPRAHSEVI 

      1090       1100       1110       1120       1130       1140 
KRKVVEFLAM LKNTVPITFP SSYKDALKDV EERAQAIIDT TDDSTATESA SSSVMSPSFS 


SE 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a new MAGE gene with tumor-specific expression by representational difference analysis."
Lucas S., De Smet C., Arden K.C., Viars C.S., Lethe B.G., Lurquin C., Boon T.
Cancer Res. 58:743-752(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS TYR-25; ILE-151 AND GLN-327.
Tissue: Melanoma.
[2]"Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library."
Chen Y.-T., Gure A.O., Tsang S., Stockert E., Jager E., Knuth A., Old L.J.
Proc. Natl. Acad. Sci. U.S.A. 95:6919-6923(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ILE-151 AND GLN-327.
Tissue: Melanoma.
[3]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF064589 Genomic DNA. Translation: AAC18837.1.
AF056334 mRNA. Translation: AAC24227.1.
AL022152 Genomic DNA. Translation: CAD27434.1.
CCDSCCDS35417.1.
RefSeqNP_005453.2. NM_005462.4.
UniGeneHs.132194.

3D structure databases

ProteinModelPortalO60732.
SMRO60732. Positions 898-1107.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115272. 10 interactions.
IntActO60732. 7 interactions.
STRING9606.ENSP00000285879.

PTM databases

PhosphoSiteO60732.

Proteomic databases

MaxQBO60732.
PaxDbO60732.
PRIDEO60732.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000285879; ENSP00000285879; ENSG00000155495.
GeneID9947.
KEGGhsa:9947.
UCSCuc004fbt.3. human.

Organism-specific databases

CTD9947.
GeneCardsGC0XP140991.
H-InvDBHIX0203313.
HGNCHGNC:6812. MAGEC1.
HPACAB015452.
HPA004622.
MIM300223. gene.
neXtProtNX_O60732.
PharmGKBPA30558.
GenAtlasSearch...

Phylogenomic databases

eggNOGKOG4562.
HOGENOMHOG000113459.
InParanoidO60732.
OMASLSPHYF.
OrthoDBEOG75F4GM.
PhylomeDBO60732.
TreeFamTF328505.

Gene expression databases

ArrayExpressO60732.
BgeeO60732.
CleanExHS_MAGEC1.
GenevestigatorO60732.

Family and domain databases

InterProIPR002190. MAGE.
[Graphical view]
PANTHERPTHR11736. PTHR11736. 1 hit.
PfamPF01454. MAGE. 1 hit.
[Graphical view]
PROSITEPS50838. MAGE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi9947.
NextBio37528.
PROO60732.
SOURCESearch...

Entry information

Entry nameMAGC1_HUMAN
AccessionPrimary (citable) accession number: O60732
Secondary accession number(s): O75451, Q8TCV4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 27, 2006
Last modified: July 9, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM