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Protein

Melanoma-associated antigen C1

Gene

MAGEC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Keywords - Molecular functioni

Tumor antigen

Enzyme and pathway databases

BioCyciZFISH:ENSG00000155495-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen C1
Alternative name(s):
Cancer/testis antigen 7.1
Short name:
CT7.1
MAGE-C1 antigen
Gene namesi
Name:MAGEC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:6812. MAGEC1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi9947.
OpenTargetsiENSG00000155495.
PharmGKBiPA30558.

Polymorphism and mutation databases

BioMutaiMAGEC1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001567201 – 1142Melanoma-associated antigen C1Add BLAST1142

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63PhosphoserineCombined sources1
Modified residuei207PhosphoserineCombined sources1
Modified residuei382PhosphoserineCombined sources1
Modified residuei1063PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO60732.
MaxQBiO60732.
PaxDbiO60732.
PeptideAtlasiO60732.
PRIDEiO60732.

PTM databases

iPTMnetiO60732.
PhosphoSitePlusiO60732.

Expressioni

Tissue specificityi

Expressed in testis and in tumors of a wide variety of histologic types.

Gene expression databases

BgeeiENSG00000155495.
CleanExiHS_MAGEC1.
GenevisibleiO60732. HS.

Organism-specific databases

HPAiCAB015452.
HPA004622.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CTAG1BP783586EBI-1188463,EBI-1188472

Protein-protein interaction databases

BioGridi115272. 10 interactors.
IntActiO60732. 7 interactors.
STRINGi9606.ENSP00000285879.

Structurei

3D structure databases

ProteinModelPortaliO60732.
SMRiO60732.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini908 – 1106MAGEPROSITE-ProRule annotationAdd BLAST199

Sequence similaritiesi

Contains 1 MAGE domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000113459.
InParanoidiO60732.
OMAiSPHYFPQ.
OrthoDBiEOG091G0TJ0.
PhylomeDBiO60732.
TreeFamiTF328505.

Family and domain databases

InterProiIPR002190. MHD_dom.
[Graphical view]
PfamiPF01454. MAGE. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60732-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDKDMPTAG MPSLLQSSSE SPQSCPEGED SQSPLQIPQS SPESDDTLYP
60 70 80 90 100
LQSPQSRSEG EDSSDPLQRP PEGKDSQSPL QIPQSSPEGD DTQSPLQNSQ
110 120 130 140 150
SSPEGKDSLS PLEISQSPPE GEDVQSPLQN PASSFFSSAL LSIFQSSPES
160 170 180 190 200
TQSPFEGFPQ SVLQIPVSAA SSSTLVSIFQ SSPESTQSPF EGFPQSPLQI
210 220 230 240 250
PVSRSFSSTL LSIFQSSPER TQSTFEGFAQ SPLQIPVSPS SSSTLLSLFQ
260 270 280 290 300
SFSERTQSTF EGFAQSSLQI PVSPSFSSTL VSLFQSSPER TQSTFEGFPQ
310 320 330 340 350
SPLQIPVSSS SSSTLLSLFQ SSPERTHSTF EGFPQSLLQI PMTSSFSSTL
360 370 380 390 400
LSIFQSSPES AQSTFEGFPQ SPLQIPGSPS FSSTLLSLFQ SSPERTHSTF
410 420 430 440 450
EGFPQSPLQI PMTSSFSSTL LSILQSSPES AQSAFEGFPQ SPLQIPVSSS
460 470 480 490 500
FSYTLLSLFQ SSPERTHSTF EGFPQSPLQI PVSSSSSSST LLSLFQSSPE
510 520 530 540 550
CTQSTFEGFP QSPLQIPQSP PEGENTHSPL QIVPSLPEWE DSLSPHYFPQ
560 570 580 590 600
SPPQGEDSLS PHYFPQSPPQ GEDSLSPHYF PQSPQGEDSL SPHYFPQSPP
610 620 630 640 650
QGEDSMSPLY FPQSPLQGEE FQSSLQSPVS ICSSSTPSSL PQSFPESSQS
660 670 680 690 700
PPEGPVQSPL HSPQSPPEGM HSQSPLQSPE SAPEGEDSLS PLQIPQSPLE
710 720 730 740 750
GEDSLSSLHF PQSPPEWEDS LSPLHFPQFP PQGEDFQSSL QSPVSICSSS
760 770 780 790 800
TSLSLPQSFP ESPQSPPEGP AQSPLQRPVS SFFSYTLASL LQSSHESPQS
810 820 830 840 850
PPEGPAQSPL QSPVSSFPSS TSSSLSQSSP VSSFPSSTSS SLSKSSPESP
860 870 880 890 900
LQSPVISFSS STSLSPFSEE SSSPVDEYTS SSDTLLESDS LTDSESLIES
910 920 930 940 950
EPLFTYTLDE KVDELARFLL LKYQVKQPIT KAEMLTNVIS RYTGYFPVIF
960 970 980 990 1000
RKAREFIEIL FGISLREVDP DDSYVFVNTL DLTSEGCLSD EQGMSQNRLL
1010 1020 1030 1040 1050
ILILSIIFIK GTYASEEVIW DVLSGIGVRA GREHFAFGEP RELLTKVWVQ
1060 1070 1080 1090 1100
EHYLEYREVP NSSPPRYEFL WGPRAHSEVI KRKVVEFLAM LKNTVPITFP
1110 1120 1130 1140
SSYKDALKDV EERAQAIIDT TDDSTATESA SSSVMSPSFS SE
Length:1,142
Mass (Da):123,643
Last modified:June 27, 2006 - v3
Checksum:i6C9AE820156F3C50
GO
Isoform 2 (identifier: O60732-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-933: Missing.

Note: No experimental confirmation available.
Show »
Length:209
Mass (Da):23,747
Checksum:i402F6EAF6A78C72B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti221 – 225TQSTF → SQRTS (PubMed:9485030).Curated5
Sequence conflicti221 – 225TQSTF → SQRTS (PubMed:9618514).Curated5
Sequence conflicti239P → S (PubMed:9485030).Curated1
Sequence conflicti239P → S (PubMed:9618514).Curated1
Sequence conflicti252 – 253FS → SP (PubMed:9485030).Curated2
Sequence conflicti252 – 253FS → SP (PubMed:9618514).Curated2
Sequence conflicti264A → P (PubMed:9485030).Curated1
Sequence conflicti264A → P (PubMed:9618514).Curated1
Sequence conflicti267S → P (PubMed:9485030).Curated1
Sequence conflicti267S → P (PubMed:9618514).Curated1
Sequence conflicti274P → R (PubMed:9485030).Curated1
Sequence conflicti274P → R (PubMed:9618514).Curated1
Sequence conflicti281 – 283VSL → LSI (PubMed:9485030).Curated3
Sequence conflicti281 – 283VSL → LSI (PubMed:9618514).Curated3
Sequence conflicti299P → A (PubMed:9485030).Curated1
Sequence conflicti299P → A (PubMed:9618514).Curated1
Sequence conflicti309 – 311SSS → PSF in AAC24227 (PubMed:9618514).Curated3
Sequence conflicti316 – 318LSL → VSI in AAC24227 (PubMed:9618514).Curated3
Sequence conflicti337L → P in AAC24227 (PubMed:9618514).Curated1
Sequence conflicti342 – 343MT → VS in AAC24227 (PubMed:9618514).Curated2
Sequence conflicti353I → L in AAC24227 (PubMed:9618514).Curated1
Sequence conflicti360 – 361SA → RT in AAC24227 (PubMed:9618514).Curated2
Sequence conflicti467H → Q in AAC18837 (PubMed:9485030).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05350125C → Y.1 PublicationCorresponds to variant rs176036dbSNPEnsembl.1
Natural variantiVAR_053502151T → I.2 PublicationsCorresponds to variant rs176037dbSNPEnsembl.1
Natural variantiVAR_053503257Q → H.Corresponds to variant rs176047dbSNPEnsembl.1
Natural variantiVAR_053504276F → S.Corresponds to variant rs1055491dbSNPEnsembl.1
Natural variantiVAR_060068327H → Q.2 PublicationsCorresponds to variant rs176047dbSNPEnsembl.1
Natural variantiVAR_062121709H → Y.Corresponds to variant rs56256227dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0563821 – 933Missing in isoform 2. 1 PublicationAdd BLAST933

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064589 Genomic DNA. Translation: AAC18837.1.
AF056334 mRNA. Translation: AAC24227.1.
AL022152 Genomic DNA. Translation: CAD27434.1.
BC127771 mRNA. Translation: AAI27772.1.
CCDSiCCDS35417.1. [O60732-1]
RefSeqiNP_005453.2. NM_005462.4. [O60732-1]
XP_011529720.1. XM_011531418.2. [O60732-1]
UniGeneiHs.132194.

Genome annotation databases

EnsembliENST00000285879; ENSP00000285879; ENSG00000155495. [O60732-1]
ENST00000406005; ENSP00000385500; ENSG00000155495. [O60732-2]
GeneIDi9947.
KEGGihsa:9947.
UCSCiuc004fbt.4. human. [O60732-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064589 Genomic DNA. Translation: AAC18837.1.
AF056334 mRNA. Translation: AAC24227.1.
AL022152 Genomic DNA. Translation: CAD27434.1.
BC127771 mRNA. Translation: AAI27772.1.
CCDSiCCDS35417.1. [O60732-1]
RefSeqiNP_005453.2. NM_005462.4. [O60732-1]
XP_011529720.1. XM_011531418.2. [O60732-1]
UniGeneiHs.132194.

3D structure databases

ProteinModelPortaliO60732.
SMRiO60732.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115272. 10 interactors.
IntActiO60732. 7 interactors.
STRINGi9606.ENSP00000285879.

PTM databases

iPTMnetiO60732.
PhosphoSitePlusiO60732.

Polymorphism and mutation databases

BioMutaiMAGEC1.

Proteomic databases

EPDiO60732.
MaxQBiO60732.
PaxDbiO60732.
PeptideAtlasiO60732.
PRIDEiO60732.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285879; ENSP00000285879; ENSG00000155495. [O60732-1]
ENST00000406005; ENSP00000385500; ENSG00000155495. [O60732-2]
GeneIDi9947.
KEGGihsa:9947.
UCSCiuc004fbt.4. human. [O60732-1]

Organism-specific databases

CTDi9947.
DisGeNETi9947.
GeneCardsiMAGEC1.
H-InvDBHIX0203313.
HGNCiHGNC:6812. MAGEC1.
HPAiCAB015452.
HPA004622.
MIMi300223. gene.
neXtProtiNX_O60732.
OpenTargetsiENSG00000155495.
PharmGKBiPA30558.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000113459.
InParanoidiO60732.
OMAiSPHYFPQ.
OrthoDBiEOG091G0TJ0.
PhylomeDBiO60732.
TreeFamiTF328505.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000155495-MONOMER.

Miscellaneous databases

GenomeRNAii9947.
PROiO60732.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155495.
CleanExiHS_MAGEC1.
GenevisibleiO60732. HS.

Family and domain databases

InterProiIPR002190. MHD_dom.
[Graphical view]
PfamiPF01454. MAGE. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAGC1_HUMAN
AccessioniPrimary (citable) accession number: O60732
Secondary accession number(s): A0PK03, O75451, Q8TCV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 27, 2006
Last modified: November 2, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.