Reviewed, UniProtKB/Swiss-Prot O60732 (MAGC1_HUMAN)

Names and origin

Protein names

Recommended name:
    Melanoma-associated antigen C1
Alternative name(s):
    MAGE-C1 antigen
    Cancer/testis antigen 7.1
      Short name=CT7.1

Gene names

Name:

MAGEC1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1142 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Tissue specificity	Expressed in testis and in tumors of a wide variety of histologic types.
Sequence similarities	Contains 1 MAGE domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat
Molecular function	Tumor antigen
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CTAG1A	P78358	2	EBI-1188463,EBI-1188472

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1142	1142	Melanoma-associated antigen C1		PRO_0000156720
Regions
	Domain	908 – 1106	199	MAGE
Natural variations
	Natural variant	25	1	C → Y: dbSNP rs176036. Ref.1		VAR_053501
	Natural variant	151	1	T → I: dbSNP rs176037. Ref.1 Ref.2		VAR_053502
	Natural variant	257	1	Q → H: dbSNP rs176047.		VAR_053503
	Natural variant	276	1	F → S: dbSNP rs1055491.		VAR_053504
	Natural variant	327	1	H → Q: dbSNP rs176047. Ref.1 Ref.2		VAR_060068
	Natural variant	709	1	H → Y: dbSNP rs56256227.		VAR_062121
Experimental info
	Sequence conflict	221 – 225	5	TQSTF → SQRTS Ref.1
	Sequence conflict	221 – 225	5	TQSTF → SQRTS Ref.2
	Sequence conflict	239	1	P → S Ref.1
	Sequence conflict	239	1	P → S Ref.2
	Sequence conflict	252 – 253	2	FS → SP Ref.1
	Sequence conflict	252 – 253	2	FS → SP Ref.2
	Sequence conflict	264	1	A → P Ref.1
	Sequence conflict	264	1	A → P Ref.2
	Sequence conflict	267	1	S → P Ref.1
	Sequence conflict	267	1	S → P Ref.2
	Sequence conflict	274	1	P → R Ref.1
	Sequence conflict	274	1	P → R Ref.2
	Sequence conflict	281 – 283	3	VSL → LSI Ref.1
	Sequence conflict	281 – 283	3	VSL → LSI Ref.2
	Sequence conflict	299	1	P → A Ref.1
	Sequence conflict	299	1	P → A Ref.2
	Sequence conflict	309 – 311	3	SSS → PSF in AAC24227. Ref.2
	Sequence conflict	316 – 318	3	LSL → VSI in AAC24227. Ref.2
	Sequence conflict	337	1	L → P in AAC24227. Ref.2
	Sequence conflict	342 – 343	2	MT → VS in AAC24227. Ref.2
	Sequence conflict	353	1	I → L in AAC24227. Ref.2
	Sequence conflict	360 – 361	2	SA → RT in AAC24227. Ref.2
	Sequence conflict	467	1	H → Q in AAC18837. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O60732-1 [UniParc]. Last modified June 27, 2006. Version 3. Checksum: 6C9AE820156F3C50	FASTA	1,142	123,643
	10 20 30 40 50 60 MGDKDMPTAG MPSLLQSSSE SPQSCPEGED SQSPLQIPQS SPESDDTLYP LQSPQSRSEG 70 80 90 100 110 120 EDSSDPLQRP PEGKDSQSPL QIPQSSPEGD DTQSPLQNSQ SSPEGKDSLS PLEISQSPPE 130 140 150 160 170 180 GEDVQSPLQN PASSFFSSAL LSIFQSSPES TQSPFEGFPQ SVLQIPVSAA SSSTLVSIFQ 190 200 210 220 230 240 SSPESTQSPF EGFPQSPLQI PVSRSFSSTL LSIFQSSPER TQSTFEGFAQ SPLQIPVSPS 250 260 270 280 290 300 SSSTLLSLFQ SFSERTQSTF EGFAQSSLQI PVSPSFSSTL VSLFQSSPER TQSTFEGFPQ 310 320 330 340 350 360 SPLQIPVSSS SSSTLLSLFQ SSPERTHSTF EGFPQSLLQI PMTSSFSSTL LSIFQSSPES 370 380 390 400 410 420 AQSTFEGFPQ SPLQIPGSPS FSSTLLSLFQ SSPERTHSTF EGFPQSPLQI PMTSSFSSTL 430 440 450 460 470 480 LSILQSSPES AQSAFEGFPQ SPLQIPVSSS FSYTLLSLFQ SSPERTHSTF EGFPQSPLQI 490 500 510 520 530 540 PVSSSSSSST LLSLFQSSPE CTQSTFEGFP QSPLQIPQSP PEGENTHSPL QIVPSLPEWE 550 560 570 580 590 600 DSLSPHYFPQ SPPQGEDSLS PHYFPQSPPQ GEDSLSPHYF PQSPQGEDSL SPHYFPQSPP 610 620 630 640 650 660 QGEDSMSPLY FPQSPLQGEE FQSSLQSPVS ICSSSTPSSL PQSFPESSQS PPEGPVQSPL 670 680 690 700 710 720 HSPQSPPEGM HSQSPLQSPE SAPEGEDSLS PLQIPQSPLE GEDSLSSLHF PQSPPEWEDS 730 740 750 760 770 780 LSPLHFPQFP PQGEDFQSSL QSPVSICSSS TSLSLPQSFP ESPQSPPEGP AQSPLQRPVS 790 800 810 820 830 840 SFFSYTLASL LQSSHESPQS PPEGPAQSPL QSPVSSFPSS TSSSLSQSSP VSSFPSSTSS 850 860 870 880 890 900 SLSKSSPESP LQSPVISFSS STSLSPFSEE SSSPVDEYTS SSDTLLESDS LTDSESLIES 910 920 930 940 950 960 EPLFTYTLDE KVDELARFLL LKYQVKQPIT KAEMLTNVIS RYTGYFPVIF RKAREFIEIL 970 980 990 1000 1010 1020 FGISLREVDP DDSYVFVNTL DLTSEGCLSD EQGMSQNRLL ILILSIIFIK GTYASEEVIW 1030 1040 1050 1060 1070 1080 DVLSGIGVRA GREHFAFGEP RELLTKVWVQ EHYLEYREVP NSSPPRYEFL WGPRAHSEVI 1090 1100 1110 1120 1130 1140 KRKVVEFLAM LKNTVPITFP SSYKDALKDV EERAQAIIDT TDDSTATESA SSSVMSPSFS SE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a new MAGE gene with tumor-specific expression by representational difference analysis." Lucas S., De Smet C., Arden K.C., Viars C.S., Lethe B.G., Lurquin C., Boon T. Cancer Res. 58:743-752(1998) [PubMed: 9485030] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS TYR-25; ILE-151 AND GLN-327. Tissue: Melanoma.
[2]	"Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library." Chen Y.-T., Gure A.O., Tsang S., Stockert E., Jager E., Knuth A., Old L.J. Proc. Natl. Acad. Sci. U.S.A. 95:6919-6923(1998) [PubMed: 9618514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ILE-151 AND GLN-327. Tissue: Melanoma.
[3]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF064589 Genomic DNA. Translation: AAC18837.1. AF056334 mRNA. Translation: AAC24227.1. AL022152 Genomic DNA. Translation: CAD27434.1.
IPI	IPI00299085.
RefSeq	NP_005453.2.
UniGene	Hs.132194
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O60732. 7 interactions.
STRING	O60732.
PTM databases
PhosphoSite	O60732.
Proteomic databases
PRIDE	O60732.
Genome annotation databases
Ensembl	ENST00000285879; ENSP00000285879; ENSG00000155495; Homo sapiens. [Genome view]
GeneID	9947.
KEGG	hsa:9947.
UCSC	uc004fbt.1. human.
Organism-specific databases
CTD	9947.
GeneCards	GC0XP140819.
H-InvDB	HIX0056126.
HGNC	HGNC:6812. MAGEC1.
HPA	CAB015452. HPA004622.
MIM	300223. gene.
PharmGKB	PA30558.
GenAtlas	Search...
Phylogenomic databases
InParanoid	O60732.
OMA	SLSPHYF.
OrthoDB	EOG92C0XC.
Gene expression databases
ArrayExpress	O60732.
Bgee	O60732.
CleanEx	HS_MAGEC1.
Genevestigator	O60732.
Family and domain databases
InterPro	IPR002190. MAGE. [Graphical view]
PANTHER	PTHR11736. MAGE. 1 hit.
Pfam	PF01454. MAGE. 1 hit. [Graphical view]
PROSITE	PS50838. MAGE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	37528.
SOURCE	Search...

Entry information

Entry name

MAGC1_HUMAN

Accession

Primary (citable) accession number: O60732
Secondary accession number(s): O75451, Q8TCV4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	June 27, 2006
Last modified:	December 15, 2009
This is version 70 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.