Reviewed,
UniProtKB/Swiss-Prot O60732 (MAGC1_HUMAN)
Last modified
July 22, 2008.
Version 54.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Melanoma-associated antigen C1 Alternative name(s): MAGE-C1 antigen Cancer/testis antigen 7.1 Short name(s)=CT7.1 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 1142 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Tissue specificity | Expressed in testis and in tumors of a wide variety of histologic types. |
| Sequence similarities | Contains 1 MAGE domain. |
Ontologies
Keywords | |
|---|---|
| Domain | Repeat |
| Molecular function | Tumor antigen |
Gene Ontology (GO) | |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||
Molecule processing | ||||||||
|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1142 | 1142 | Melanoma-associated antigen C1 | |||||
Regions | ||||||||
| Domain | 908 – 1106 | 199 | MAGE | |||||
Experimental info | ||||||||
| Sequence conflict | 25 | 1 | C → Y in AAC18837. Ref.1 | |||||
| Sequence conflict | 151 | 1 | T → I Ref.1 Ref.2 | |||||
| Sequence conflict | 221 – 225 | 5 | TQSTF → SQRTS Ref.1 Ref.2 | |||||
| Sequence conflict | 239 | 1 | P → S Ref.1 Ref.2 | |||||
| Sequence conflict | 252 – 253 | 2 | FS → SP Ref.1 Ref.2 | |||||
| Sequence conflict | 264 | 1 | A → P Ref.1 Ref.2 | |||||
| Sequence conflict | 267 | 1 | S → P Ref.1 Ref.2 | |||||
| Sequence conflict | 274 | 1 | P → R Ref.1 Ref.2 | |||||
| Sequence conflict | 281 – 283 | 3 | VSL → LSI Ref.1 Ref.2 | |||||
| Sequence conflict | 299 | 1 | P → A Ref.1 Ref.2 | |||||
| Sequence conflict | 309 – 311 | 3 | SSS → PSF in AAC24227. Ref.2 | |||||
| Sequence conflict | 316 – 318 | 3 | LSL → VSI in AAC24227. Ref.2 | |||||
| Sequence conflict | 327 | 1 | H → Q Ref.1 Ref.2 | |||||
| Sequence conflict | 337 | 1 | L → P in AAC24227. Ref.2 | |||||
| Sequence conflict | 342 – 343 | 2 | MT → VS in AAC24227. Ref.2 | |||||
| Sequence conflict | 353 | 1 | I → L in AAC24227. Ref.2 | |||||
| Sequence conflict | 360 – 361 | 2 | SA → RT in AAC24227. Ref.2 | |||||
| Sequence conflict | 467 | 1 | H → Q in AAC18837. Ref.1 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification of a new MAGE gene with tumor-specific expression by representational difference analysis." Lucas S., De Smet C., Arden K.C., Viars C.S., Lethe B.G., Lurquin C., Boon T. Cancer Res. 58:743-752(1998) [PubMed: 9485030] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Melanoma. |
| [2] | "Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library." Chen Y.-T., Gure A.O., Tsang S., Stockert E., Jager E., Knuth A., Old L.J. Proc. Natl. Acad. Sci. U.S.A. 95:6919-6923(1998) [PubMed: 9618514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Melanoma. |
| [3] | "The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. Bentley D.R.Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| AF064589 Genomic DNA. Translation: AAC18837.1. AF056334 mRNA. Translation: AAC24227.1. AL022152 Genomic DNA. Translation: CAD27434.1. | |
| RefSeq | NP_005453.2. |
| UniGene | Hs.132194 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O60732. |
PTM databases | |
| PhosphoSite | O60732. |
Genome annotation databases | |
| Ensembl | ENSG00000155495. Homo sapiens. [Contig view] |
| GeneID | 9947. |
| KEGG | hsa:9947. |
Organism-specific databases | |
| H-InvDB | HIX0056126. |
| HGNC | HGNC:6812. MAGEC1. |
| HPA | CAB015452. HPA004622. |
| MIM | 300223. gene. |
| PharmGKB | PA30558. |
| GenAtlas | Search... |
| GeneCards | Search... |
| GeneLynx | Search... |
Phylogenomic databases | |
| HOGENOM | O60732. |
| HOVERGEN | O60732. |
Gene expression databases | |
| ArrayExpress | O60732. |
| CleanEx | HS_MAGEC1. |
Family and domain databases | |
| InterPro | IPR002190. MAGE. [Graphical view] |
| PANTHER | PTHR11736. MAGE. 1 hit. |
| Pfam | PF01454. MAGE. 1 hit. [Graphical view] |
| PROSITE | PS50838. MAGE. 1 hit. [Graphical view] |
| ProDom | O60732. [Graphical view] [Entries sharing at least one domain] |
| BLOCKS | Search... |
Other Resources | |
| SOURCE | Search... |
| ProtoNet | Search... |
Entry information
| Entry name | MAGC1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O60732 Secondary accession number(s): O75451, Q8TCV4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome X Human chromosome X: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

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