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O60721

- NCKX1_HUMAN

UniProt

O60721 - NCKX1_HUMAN

Protein

Sodium/potassium/calcium exchanger 1

Gene

SLC24A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca2+ and 1 K+ in exchange for 4 Na+.1 Publication

    GO - Molecular functioni

    1. calcium, potassium:sodium antiporter activity Source: UniProtKB
    2. protein binding Source: IntAct
    3. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. calcium ion transport Source: UniProtKB
    2. ion transport Source: Reactome
    3. phototransduction, visible light Source: Reactome
    4. response to light intensity Source: UniProtKB
    5. rhodopsin mediated signaling pathway Source: Reactome
    6. sodium ion transmembrane transport Source: GOC
    7. transmembrane transport Source: Reactome
    8. transport Source: ProtInc
    9. visual perception Source: UniProtKB

    Keywords - Biological processi

    Antiport, Calcium transport, Ion transport, Sensory transduction, Symport, Transport, Vision

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_163932. Activation of the phototransduction cascade.
    REACT_19320. Sodium/Calcium exchangers.

    Protein family/group databases

    TCDBi2.A.19.4.9. the ca(2+):cation antiporter (caca) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/potassium/calcium exchanger 1
    Alternative name(s):
    Na(+)/K(+)/Ca(2+)-exchange protein 1
    Retinal rod Na-Ca+K exchanger
    Solute carrier family 24 member 1
    Gene namesi
    Name:SLC24A1
    Synonyms:KIAA0702, NCKX1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:10975. SLC24A1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. membrane Source: ProtInc
    3. outer membrane Source: UniProtKB
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Night blindness, congenital stationary, 1D (CSNB1D) [MIM:613830]: An autosomal recessive form of congenital stationary night blindness, a non-progressive retinal disorder characterized by impaired night vision. CSNB1D is characterized by a Riggs type of electroretinogram (proportionally reduced a- and b-waves). Patients have visual acuity within the normal range and no symptoms of myopia and/or nystagmus.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Congenital stationary night blindness

    Organism-specific databases

    MIMi613830. phenotype.
    Orphaneti215. Congenital stationary night blindness.
    PharmGKBiPA35851.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10991099Sodium/potassium/calcium exchanger 1PRO_0000223303Add
    BLAST
    Signal peptidei1 – ?Not cleaved

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence Analysis
    Modified residuei658 – 6581PhosphoserineSequence Analysis
    Modified residuei724 – 7241Phosphothreonine1 Publication
    Modified residuei726 – 7261Phosphothreonine1 Publication

    Post-translational modificationi

    The uncleaved signal sequence is required for efficient membrane targeting and proper membrane integration.

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiO60721.
    PaxDbiO60721.
    PRIDEiO60721.

    PTM databases

    PhosphoSiteiO60721.

    Expressioni

    Tissue specificityi

    Expressed in the retina, particularly in the inner segment, outer and inner nuclear layers, and ganglion cell layer.1 Publication

    Gene expression databases

    ArrayExpressiO60721.
    BgeeiO60721.
    CleanExiHS_SLC24A1.
    GenevestigatoriO60721.

    Organism-specific databases

    HPAiHPA039370.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NCK1P163333EBI-1753504,EBI-389883

    Protein-protein interaction databases

    BioGridi114624. 2 interactions.
    IntActiO60721. 5 interactions.
    STRINGi9606.ENSP00000261892.

    Structurei

    3D structure databases

    ProteinModelPortaliO60721.
    SMRiO60721. Positions 475-602, 909-1054.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 452452ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini474 – 49724CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini519 – 5224ExtracellularSequence Analysis
    Topological domaini544 – 56320CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini585 – 5851ExtracellularSequence Analysis
    Topological domaini607 – 907301CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini929 – 9357ExtracellularSequence Analysis
    Topological domaini957 – 97115CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini993 – 101018ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1032 – 10398CytoplasmicSequence Analysis
    Topological domaini1061 – 10688ExtracellularSequence Analysis
    Topological domaini1090 – 109910CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei453 – 47321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei498 – 51821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei523 – 54321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei564 – 58421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei586 – 60621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei908 – 92821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei936 – 95621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei972 – 99221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1011 – 103121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1040 – 106021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1069 – 108921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati494 – 53441Alpha-1Add
    BLAST
    Repeati979 – 101032Alpha-2Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi860 – 89031Poly-GluAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0530.
    HOGENOMiHOG000231933.
    HOVERGENiHBG104097.
    InParanoidiO60721.
    KOiK13749.
    OMAiKGEYPPD.
    PhylomeDBiO60721.
    TreeFamiTF318759.

    Family and domain databases

    InterProiIPR004817. K-dep_Na/Ca-exchanger.
    IPR004481. K/Na/Ca-exchanger.
    IPR004837. NaCa_Exmemb.
    [Graphical view]
    PANTHERiPTHR10846. PTHR10846. 1 hit.
    PfamiPF01699. Na_Ca_ex. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00927. 2A1904. 1 hit.
    TIGR00367. TIGR00367. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O60721-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGKLIRMGPQ ERWLLRTKRL HWSRLLFLLG MLIIGSTYQH LRRPRGLSSL     50
    WAAVSSHQPI KLASRDLSSE EMMMMSSSPS KPSSEMGGKM LVPQASVGSD 100
    EATLSMTVEN IPSMPKRTAK MIPTTTKNNY SPTAAGTERR KEDTPTSSRT 150
    LTYYTSTSSR QIVKKYTPTP RGEMKSYSPT QVREKVKYTP SPRGRRVGTY 200
    VPSTFMTMET SHAITPRTTV KDSDITATYK ILETNSLKRI MEETTPTTLK 250
    GMFDSTPTFL THEVEANVLT SPRSVMEKNN LFPPRRVESN SSAHPWGLVG 300
    KSNPKTPQGT VLLHTPATSE GQVTISTMTG SSPAETKAFT AAWSLRNPSP 350
    RTSVSAIKTA PAIVWRLAKK PSTAPSTSTT PTVRAKLTMQ VHHCVVVKPT 400
    PAMLTTPSPS LTTALLPEEL SPSPSVLPPS LPDLHPKGEY PPDLFSVEER 450
    RQGWVVLHVF GMMYVFVALA IVCDEYFVPA LGVITDKLQI SEDVAGATFM 500
    AAGGSAPELF TSLIGVFISH SNVGIGTIVG SAVFNILFVI GTCSLFSREI 550
    LNLTWWPLFR DVSFYILDLI MLILFFLDSL IAWWESLLLL LAYAFYVFTM 600
    KWNKHIEVWV KEQLSRRPVA KVMALEDLSK PGDGAIAVDE LQDNKKLKLP 650
    SLLTRGSSST SLHNSTIRST IYQLMLHSLD PLREVRLAKE KEEESLNQGA 700
    RAQPQAKAES KPEEEEPAKL PAVTVTPAPV PDIKGDQKEN PGGQEDVAEA 750
    ESTGEMPGEE GETAGEGETE EKSGGETQPE GEGETETQGK GEECEDENEA 800
    EGKGDNEGED EGEIHAEDGE MKGNEGETES QELSAENHGE AKNDEKGVED 850
    GGGSDGGDSE EEEEEEEEQE EEEEEEEQEE EEEEEEEEEE KGNEEPLSLD 900
    WPETRQKQAI YLFLLPIVFP LWLTVPDVRR QESRKFFVFT FLGSIMWIAM 950
    FSYLMVWWAH QVGETIGISE EIMGLTILAA GTSIPDLITS VIVARKGLGD 1000
    MAVSSSVGSN IFDITVGLPV PWLLFSLING LQPVPVSSNG LFCAIVLLFL 1050
    MLLFVISSIA SCKWRMNKIL GFTMFLLYFV FLIISVMLED RIISCPVSV 1099
    Length:1,099
    Mass (Da):121,374
    Last modified:August 1, 1998 - v1
    Checksum:i3911856BB088B5FD
    GO
    Isoform 2 (identifier: O60721-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         631-648: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,081
    Mass (Da):119,481
    Checksum:iA72589F54E4C05B3
    GO
    Isoform 3 (identifier: O60721-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         932-961: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,069
    Mass (Da):117,632
    Checksum:iBC2036012DF4E930
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti516 – 5161V → I in AAB97832. (PubMed:9478004)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti37 – 371T → S.
    Corresponds to variant rs3743171 [ dbSNP | Ensembl ].
    VAR_050221
    Natural varianti311 – 3111V → L.
    Corresponds to variant rs34363823 [ dbSNP | Ensembl ].
    VAR_050222
    Natural varianti313 – 3131L → V.
    Corresponds to variant rs35571449 [ dbSNP | Ensembl ].
    VAR_050223

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei631 – 64818Missing in isoform 2. 2 PublicationsVSP_006160Add
    BLAST
    Alternative sequencei932 – 96130Missing in isoform 3. 1 PublicationVSP_054491Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF062921 mRNA. Translation: AAC16732.1.
    AF062922 mRNA. Translation: AAC77912.1.
    AF026132 mRNA. Translation: AAB97832.1.
    AC011939 Genomic DNA. No translation available.
    AC027220 Genomic DNA. No translation available.
    BC117263 mRNA. Translation: AAI17264.1.
    BC143375 mRNA. Translation: AAI43376.1.
    AB014602 mRNA. Translation: BAA31677.2. Sequence problems.
    CCDSiCCDS45284.1. [O60721-1]
    RefSeqiNP_004718.1. NM_004727.2. [O60721-1]
    XP_005254835.1. XM_005254778.2. [O60721-1]
    XP_005254836.1. XM_005254779.2. [O60721-2]
    XP_006720827.1. XM_006720764.1. [O60721-1]
    XP_006720828.1. XM_006720765.1. [O60721-1]
    XP_006720829.1. XM_006720766.1. [O60721-3]
    UniGeneiHs.173092.

    Genome annotation databases

    EnsembliENST00000261892; ENSP00000261892; ENSG00000074621. [O60721-1]
    ENST00000339868; ENSP00000341837; ENSG00000074621. [O60721-2]
    ENST00000399033; ENSP00000381991; ENSG00000074621. [O60721-3]
    ENST00000546330; ENSP00000439190; ENSG00000074621. [O60721-2]
    GeneIDi9187.
    KEGGihsa:9187.
    UCSCiuc010ujf.2. human. [O60721-1]
    uc010ujh.2. human. [O60721-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF062921 mRNA. Translation: AAC16732.1 .
    AF062922 mRNA. Translation: AAC77912.1 .
    AF026132 mRNA. Translation: AAB97832.1 .
    AC011939 Genomic DNA. No translation available.
    AC027220 Genomic DNA. No translation available.
    BC117263 mRNA. Translation: AAI17264.1 .
    BC143375 mRNA. Translation: AAI43376.1 .
    AB014602 mRNA. Translation: BAA31677.2 . Sequence problems.
    CCDSi CCDS45284.1. [O60721-1 ]
    RefSeqi NP_004718.1. NM_004727.2. [O60721-1 ]
    XP_005254835.1. XM_005254778.2. [O60721-1 ]
    XP_005254836.1. XM_005254779.2. [O60721-2 ]
    XP_006720827.1. XM_006720764.1. [O60721-1 ]
    XP_006720828.1. XM_006720765.1. [O60721-1 ]
    XP_006720829.1. XM_006720766.1. [O60721-3 ]
    UniGenei Hs.173092.

    3D structure databases

    ProteinModelPortali O60721.
    SMRi O60721. Positions 475-602, 909-1054.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114624. 2 interactions.
    IntActi O60721. 5 interactions.
    STRINGi 9606.ENSP00000261892.

    Protein family/group databases

    TCDBi 2.A.19.4.9. the ca(2+):cation antiporter (caca) family.

    PTM databases

    PhosphoSitei O60721.

    Proteomic databases

    MaxQBi O60721.
    PaxDbi O60721.
    PRIDEi O60721.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261892 ; ENSP00000261892 ; ENSG00000074621 . [O60721-1 ]
    ENST00000339868 ; ENSP00000341837 ; ENSG00000074621 . [O60721-2 ]
    ENST00000399033 ; ENSP00000381991 ; ENSG00000074621 . [O60721-3 ]
    ENST00000546330 ; ENSP00000439190 ; ENSG00000074621 . [O60721-2 ]
    GeneIDi 9187.
    KEGGi hsa:9187.
    UCSCi uc010ujf.2. human. [O60721-1 ]
    uc010ujh.2. human. [O60721-2 ]

    Organism-specific databases

    CTDi 9187.
    GeneCardsi GC15P065914.
    HGNCi HGNC:10975. SLC24A1.
    HPAi HPA039370.
    MIMi 603617. gene.
    613830. phenotype.
    neXtProti NX_O60721.
    Orphaneti 215. Congenital stationary night blindness.
    PharmGKBi PA35851.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0530.
    HOGENOMi HOG000231933.
    HOVERGENi HBG104097.
    InParanoidi O60721.
    KOi K13749.
    OMAi KGEYPPD.
    PhylomeDBi O60721.
    TreeFami TF318759.

    Enzyme and pathway databases

    Reactomei REACT_163932. Activation of the phototransduction cascade.
    REACT_19320. Sodium/Calcium exchangers.

    Miscellaneous databases

    GenomeRNAii 9187.
    NextBioi 34449.
    PROi O60721.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60721.
    Bgeei O60721.
    CleanExi HS_SLC24A1.
    Genevestigatori O60721.

    Family and domain databases

    InterProi IPR004817. K-dep_Na/Ca-exchanger.
    IPR004481. K/Na/Ca-exchanger.
    IPR004837. NaCa_Exmemb.
    [Graphical view ]
    PANTHERi PTHR10846. PTHR10846. 1 hit.
    Pfami PF01699. Na_Ca_ex. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00927. 2A1904. 1 hit.
    TIGR00367. TIGR00367. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Chromosomal localization and genomic organization of the human retinal rod Na-Ca+K exchanger."
      Tucker J.E., Winkfein R.J., Murthy S.K., Friedman J.S., Walter M.A., Demetrick D.J., Schnetkamp P.P.M.
      Hum. Genet. 103:411-414(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Retina.
    2. "cDNA cloning of the human retinal rod Na-Ca + K exchanger: comparison with a revised bovine sequence."
      Tucker J.E., Winkfein R.J., Cooper C.B., Schnetkamp P.P.M.
      Invest. Ophthalmol. Vis. Sci. 39:435-440(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Retina.
    3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Heart and Lung.
    5. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1003 (ISOFORM 2).
      Tissue: Brain.
    6. "The retinal rod Na(+)/Ca(2+),K(+) exchanger contains a noncleaved signal sequence required for translocation of the N-terminus."
      McKiernan C.J., Friedlander M.
      J. Biol. Chem. 274:38177-38182(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF THE N-TERMINUS IN TARGETING.
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-724 AND THR-726, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. Cited for: TISSUE SPECIFICITY, INVOLVEMENT IN CSNB1D.

    Entry informationi

    Entry nameiNCKX1_HUMAN
    AccessioniPrimary (citable) accession number: O60721
    Secondary accession number(s): O43485, O75184, Q17RM9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 13, 2001
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3