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Protein

Catenin delta-1

Gene

CTNND1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei401Essential for interaction with cadherins1
Sitei478Essential for interaction with cadherins1

GO - Molecular functioni

  • cadherin binding Source: UniProtKB
  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • receptor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Transcription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

BioCyciZFISH:G66-32089-MONOMER.
ReactomeiR-HSA-418990. Adherens junctions interactions.
R-HSA-5218920. VEGFR2 mediated vascular permeability.
SignaLinkiO60716.
SIGNORiO60716.

Names & Taxonomyi

Protein namesi
Recommended name:
Catenin delta-1
Alternative name(s):
Cadherin-associated Src substrate
Short name:
CAS
p120 catenin
Short name:
p120(ctn)
p120(cas)
Gene namesi
Name:CTNND1
Synonyms:KIAA0384
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:2515. CTNND1.

Subcellular locationi

  • Cytoplasm
  • Nucleus
  • Cell membrane

  • Note: Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm. Isoforms 4A and 1AB are excluded from the nucleus.By similarity

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cell-cell junction Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • cytosol Source: BHF-UCL
  • dendritic spine Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • growth cone Source: Ensembl
  • lamellipodium Source: Ensembl
  • midbody Source: UniProtKB
  • nucleus Source: BHF-UCL
  • plasma membrane Source: UniProtKB
  • zonula adherens Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi363W → A: Severely disrupts cadherin interaction. 1 Publication1
Mutagenesisi401K → M: Complete loss of cadherin interaction. 1 Publication1
Mutagenesisi444K → M: Severely disrupts cadherin interaction. 1 Publication1
Mutagenesisi477W → A: Severely disrupts cadherin interaction. 1 Publication1
Mutagenesisi478N → A: Complete loss of cadherin interaction. 1 Publication1

Organism-specific databases

DisGeNETi1500.
OpenTargetsiENSG00000198561.
PharmGKBiPA27016.

Polymorphism and mutation databases

BioMutaiCTNND1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642961 – 968Catenin delta-1Add BLAST968

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei4PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei59PhosphothreonineCombined sources1
Modified residuei112Phosphotyrosine; by FYN1 Publication1
Modified residuei125PhosphoserineCombined sources1
Modified residuei217PhosphotyrosineBy similarity1
Modified residuei221PhosphotyrosineBy similarity1
Modified residuei225PhosphoserineCombined sources1
Modified residuei228PhosphotyrosineBy similarity1
Modified residuei230PhosphoserineCombined sources1
Modified residuei252PhosphoserineCombined sources1
Modified residuei257PhosphotyrosineBy similarity1
Modified residuei268PhosphoserineCombined sources1
Modified residuei269PhosphoserineCombined sources1
Modified residuei280PhosphotyrosineBy similarity1
Modified residuei288Phosphoserine; by PAK5Combined sources1 Publication1
Modified residuei291PhosphotyrosineBy similarity1
Modified residuei300PhosphoserineBy similarity1
Modified residuei304PhosphothreonineBy similarity1
Modified residuei320PhosphoserineCombined sources1
Modified residuei346PhosphoserineCombined sources1
Modified residuei349PhosphoserineCombined sources1
Modified residuei352PhosphoserineCombined sources1
Modified residuei617PhosphoserineCombined sources1
Modified residuei713PhosphoserineBy similarity1
Modified residuei811PhosphoserineCombined sources1
Modified residuei847PhosphoserineCombined sources1
Modified residuei857PhosphoserineCombined sources1
Modified residuei859PhosphoserineCombined sources1
Modified residuei861PhosphoserineCombined sources1
Modified residuei864PhosphoserineCombined sources1
Modified residuei865PhosphotyrosineCombined sources1
Modified residuei868PhosphoserineCombined sources1
Modified residuei869PhosphothreonineCombined sources1
Modified residuei879PhosphoserineCombined sources1
Modified residuei899PhosphoserineBy similarity1
Modified residuei904PhosphotyrosineBy similarity1
Modified residuei906PhosphothreonineCombined sources1
Modified residuei916PhosphothreonineCombined sources1
Modified residuei920PhosphoserineCombined sources1
Modified residuei943PhosphoserineCombined sources1
Isoform 4 (identifier: O60716-32)
Modified residuei566PhosphothreonineCombined sources1
Isoform 4C (identifier: O60716-31)
Modified residuei572PhosphothreonineCombined sources1
Isoform 4A (identifier: O60716-29)
Modified residuei587PhosphothreonineCombined sources1
Isoform 4AC (identifier: O60716-27)
Modified residuei593PhosphothreonineCombined sources1
Isoform 3 (identifier: O60716-24)
Modified residuei788PhosphothreonineCombined sources1
Isoform 3C (identifier: O60716-23)
Modified residuei794PhosphothreonineCombined sources1
Isoform 3A (identifier: O60716-21)
Modified residuei809PhosphothreonineCombined sources1
Isoform 3AC (identifier: O60716-19)
Modified residuei815PhosphothreonineCombined sources1
Isoform 2 (identifier: O60716-16)
Modified residuei835PhosphothreonineCombined sources1
Isoform 2C (identifier: O60716-15)
Modified residuei841PhosphothreonineCombined sources1
Isoform 2A (identifier: O60716-13)
Modified residuei856PhosphothreonineCombined sources1
Isoform 2AC (identifier: O60716-11)
Modified residuei862PhosphothreonineCombined sources1
Isoform 1 (identifier: O60716-8)
Modified residuei889PhosphothreonineCombined sources1
Isoform 1C (identifier: O60716-7)
Modified residuei895PhosphothreonineCombined sources1
Isoform 1A (identifier: O60716-5)
Modified residuei910PhosphothreonineCombined sources1
Isoform 1AC (identifier: O60716-3)
Modified residuei916PhosphothreonineCombined sources1

Post-translational modificationi

Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK5. Dephosphorylated by PTPRJ.4 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO60716.
MaxQBiO60716.
PaxDbiO60716.
PeptideAtlasiO60716.
PRIDEiO60716.

PTM databases

iPTMnetiO60716.
PhosphoSitePlusiO60716.
SwissPalmiO60716.

Expressioni

Tissue specificityi

Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs.2 Publications

Inductioni

Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress, which enhances wound closure.1 Publication

Gene expression databases

BgeeiENSG00000198561.
ExpressionAtlasiO60716. baseline and differential.
GenevisibleiO60716. HS.

Organism-specific databases

HPAiCAB003837.
HPA015954.
HPA015955.

Interactioni

Subunit structurei

Belongs to a multiprotein cell-cell adhesion complex that also contains E-cadherin, alpha-catenin, beta-catenin, and gamma-catenin. Binds to the C-terminal fragment of PSEN1 and mutually competes for E-cadherin. Interacts with ZBTB33. Interacts with GLIS2. Interacts with NANOS1 (via N-terminal region). Interacts with FER.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Cdh1P098033EBI-702059,EBI-984420From a different organism.
EGFRP005334EBI-701927,EBI-297353
FRMD5Q7Z6J63EBI-701927,EBI-727282
KCTD6Q8NC693EBI-702059,EBI-2511344
NANOS1Q8WY412EBI-9634525,EBI-9630165
PLPP3O144959EBI-701927,EBI-766232
PTPRJQ129135EBI-701927,EBI-2264500

GO - Molecular functioni

  • cadherin binding Source: UniProtKB
  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi107881. 55 interactors.
DIPiDIP-33850N.
IntActiO60716. 41 interactors.
MINTiMINT-4999228.
STRINGi9606.ENSP00000382004.

Structurei

Secondary structure

1968
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi368 – 374Combined sources7
Helixi380 – 394Combined sources15
Helixi398 – 406Combined sources9
Helixi409 – 415Combined sources7
Helixi416 – 418Combined sources3
Helixi422 – 435Combined sources14
Beta strandi437 – 439Combined sources3
Helixi441 – 449Combined sources9
Helixi452 – 462Combined sources11
Helixi466 – 479Combined sources14
Helixi483 – 485Combined sources3
Helixi486 – 492Combined sources7
Helixi494 – 500Combined sources7
Helixi502 – 506Combined sources5
Helixi524 – 537Combined sources14
Helixi542 – 550Combined sources9
Helixi554 – 567Combined sources14
Helixi574 – 587Combined sources14
Helixi590 – 593Combined sources4
Helixi655 – 660Combined sources6
Helixi662 – 674Combined sources13
Helixi678 – 692Combined sources15
Helixi697 – 706Combined sources10
Helixi709 – 717Combined sources9
Helixi718 – 720Combined sources3
Helixi724 – 738Combined sources15
Helixi744 – 757Combined sources14
Beta strandi759 – 763Combined sources5
Helixi766 – 768Combined sources3
Helixi772 – 786Combined sources15
Helixi790 – 798Combined sources9
Helixi801 – 809Combined sources9
Beta strandi812 – 814Combined sources3
Helixi816 – 830Combined sources15
Helixi833 – 840Combined sources8
Turni841 – 843Combined sources3
Helixi846 – 849Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3L6XX-ray2.40A324-937[»]
3L6YX-ray3.00A/C/E324-937[»]
ProteinModelPortaliO60716.
SMRiO60716.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60716.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati358 – 395ARM 1Add BLAST38
Repeati398 – 437ARM 2Add BLAST40
Repeati441 – 475ARM 3Add BLAST35
Repeati476 – 516ARM 4Add BLAST41
Repeati534 – 573ARM 5Add BLAST40
Repeati583 – 624ARM 6Add BLAST42
Repeati653 – 693ARM 7Add BLAST41
Repeati700 – 739ARM 8Add BLAST40
Repeati740 – 780ARM 9Add BLAST41
Repeati781 – 826ARM 10Add BLAST46

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili10 – 46Sequence analysisAdd BLAST37

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi622 – 634Nuclear localization signalBy similarityAdd BLAST13

Domaini

A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.
ARM repeats 1 to 5 mediate interaction with cadherins.

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 10 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1048. Eukaryota.
ENOG410Y21Q. LUCA.
GeneTreeiENSGT00760000119167.
HOVERGENiHBG004284.
InParanoidiO60716.
KOiK05690.
OMAiQYYWAPL.
OrthoDBiEOG091G018C.
PhylomeDBiO60716.
TreeFamiTF321877.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028439. Catenin_d1.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 1 hit.
PTHR10372:SF6. PTHR10372:SF6. 1 hit.
PfamiPF00514. Arm. 3 hits.
[Graphical view]
SMARTiSM00185. ARM. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
[Graphical view]

Sequences (32)i

Sequence statusi: Complete.

This entry describes 32 isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

Note: Isoforms result of a combination of four transcription start sites and three alternatively spliced exons(A, B and C).
Isoform 1ABC (identifier: O60716-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDSEVESTA SILASVKEQE AQFEKLTRAL EEERRHVSAQ LERVRVSPQD
60 70 80 90 100
ANPLMANGTL TRRHQNGRFV GDADLERQKF SDLKLNGPQD HSHLLYSTIP
110 120 130 140 150
RMQEPGQIVE TYTEEDPEGA MSVVSVETSD DGTTRRTETT VKKVVKTVTT
160 170 180 190 200
RTVQPVAMGP DGLPVDASSV SNNYIQTLGR DFRKNGNGGP GPYVGQAGTA
210 220 230 240 250
TLPRNFHYPP DGYSRHYEDG YPGGSDNYGS LSRVTRIEER YRPSMEGYRA
260 270 280 290 300
PSRQDVYGPQ PQVRVGGSSV DLHRFHPEPY GLEDDQRSMG YDDLDYGMMS
310 320 330 340 350
DYGTARRTGT PSDPRRRLRS YEDMIGEEVP SDQYYWAPLA QHERGSLASL
360 370 380 390 400
DSLRKGGPPP PNWRQPELPE VIAMLGFRLD AVKSNAAAYL QHLCYRNDKV
410 420 430 440 450
KTDVRKLKGI PVLVGLLDHP KKEVHLGACG ALKNISFGRD QDNKIAIKNC
460 470 480 490 500
DGVPALVRLL RKARDMDLTE VITGTLWNLS SHDSIKMEIV DHALHALTDE
510 520 530 540 550
VIIPHSGWER EPNEDCKPRH IEWESVLTNT AGCLRNVSSE RSEARRKLRE
560 570 580 590 600
CDGLVDALIF IVQAEIGQKD SDSKLVENCV CLLRNLSYQV HREIPQAERY
610 620 630 640 650
QEAAPNVANN TGPHAASCFG AKKGKDEWFS RGKKPIEDPA NDTVDFPKRT
660 670 680 690 700
SPARGYELLF QPEVVRIYIS LLKESKTPAI LEASAGAIQN LCAGRWTYGR
710 720 730 740 750
YIRSALRQEK ALSAIADLLT NEHERVVKAA SGALRNLAVD ARNKELIGKH
760 770 780 790 800
AIPNLVKNLP GGQQNSSWNF SEDTVISILN TINEVIAENL EAAKKLRETQ
810 820 830 840 850
GIEKLVLINK SGNRSEKEVR AAALVLQTIW GYKELRKPLE KEGWKKSDFQ
860 870 880 890 900
VNLNNASRSQ SSHSYDDSTL PLIDRNQKSD KKPDREEIQM SNMGSNTKSL
910 920 930 940 950
DNNYSTPNER GDHNRTLDRS GDLGDMEPLK GTTPLMQDEG QESLEEELDV
960
LVLDDEGGQV SYPSMQKI
Length:968
Mass (Da):108,170
Last modified:August 1, 1998 - v1
Checksum:iD5C37489A891F292
GO
Isoform 1AB (identifier: O60716-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     626-631: Missing.

Show »
Length:962
Mass (Da):107,349
Checksum:i62C1AA58EC4ED712
GO
Isoform 1AC (identifier: O60716-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     937-965: Missing.

Show »
Length:939
Mass (Da):104,977
Checksum:iD436D996ECBEBDC7
GO
Isoform 1BC (identifier: O60716-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     880-900: Missing.

Show »
Length:947
Mass (Da):105,779
Checksum:i46867A61854BBEDF
GO
Isoform 1A (identifier: O60716-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     626-631: Missing.
     937-965: Missing.

Show »
Length:933
Mass (Da):104,156
Checksum:iA4E1ABA2FE3D6B54
GO
Isoform 1B (identifier: O60716-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     626-631: Missing.
     880-900: Missing.

Show »
Length:941
Mass (Da):104,958
Checksum:iA82D282A5DF1C4BE
GO
Isoform 1C (identifier: O60716-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     880-900: Missing.
     937-965: Missing.

Show »
Length:918
Mass (Da):102,586
Checksum:i17D678061E042572
GO
Isoform 1 (identifier: O60716-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     626-631: Missing.
     880-900: Missing.
     937-965: Missing.

Show »
Length:912
Mass (Da):101,765
Checksum:i879022D64712C805
GO
Isoform 2ABC (identifier: O60716-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.

Show »
Length:914
Mass (Da):102,063
Checksum:i57A26859239AA55A
GO
Isoform 2AB (identifier: O60716-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
     626-631: Missing.

Show »
Length:908
Mass (Da):101,242
Checksum:i95094A101A1B6DB4
GO
Isoform 2AC (identifier: O60716-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
     937-965: Missing.

Show »
Length:885
Mass (Da):98,870
Checksum:iDF4D8956D2827CAA
GO
Isoform 2BC (identifier: O60716-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
     880-900: Missing.

Show »
Length:893
Mass (Da):99,673
Checksum:iD0985DD5A04D4B3F
GO
Isoform 2A (identifier: O60716-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
     626-631: Missing.
     937-965: Missing.

Show »
Length:879
Mass (Da):98,049
Checksum:iF58CA78A7097EFEB
GO
Isoform 2B (identifier: O60716-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
     626-631: Missing.
     880-900: Missing.

Show »
Length:887
Mass (Da):98,852
Checksum:i1DCDD3510D31FA82
GO
Isoform 2C (identifier: O60716-15) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
     880-900: Missing.
     937-965: Missing.

Show »
Length:864
Mass (Da):96,479
Checksum:iE418647839C3B386
GO
Isoform 2 (identifier: O60716-16) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
     626-631: Missing.
     880-900: Missing.
     937-965: Missing.

Show »
Length:858
Mass (Da):95,658
Checksum:iA16496DCF8B2F524
GO
Isoform 3ABC (identifier: O60716-17) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.

Show »
Length:867
Mass (Da):96,689
Checksum:i5F9E3A466CA81D74
GO
Isoform 3AB (identifier: O60716-18) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     626-631: Missing.

Show »
Length:861
Mass (Da):95,868
Checksum:i3D2744052161BD93
GO
Isoform 3AC (identifier: O60716-19) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     937-965: Missing.

Show »
Length:838
Mass (Da):93,496
Checksum:iF840912548316394
GO
Isoform 3BC (identifier: O60716-20) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     880-900: Missing.

Show »
Length:846
Mass (Da):94,299
Checksum:iD482BB16BD5A898A
GO
Isoform 3A (identifier: O60716-21) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     626-631: Missing.
     937-965: Missing.

Show »
Length:832
Mass (Da):92,675
Checksum:iFAB29A345A6AABBC
GO
Isoform 3B (identifier: O60716-22) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     626-631: Missing.
     880-900: Missing.

Show »
Length:840
Mass (Da):93,478
Checksum:i0F78D45C15426031
GO
Isoform 3C (identifier: O60716-23) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     880-900: Missing.
     937-965: Missing.

Show »
Length:817
Mass (Da):91,105
Checksum:i7308172E06E2AC56
GO
Isoform 3 (identifier: O60716-24) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     626-631: Missing.
     880-900: Missing.
     937-965: Missing.

Show »
Length:811
Mass (Da):90,284
Checksum:i3EB46C6A74AA396C
GO
Isoform 4ABC (identifier: O60716-25) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.

Show »
Length:645
Mass (Da):72,045
Checksum:iDD32175D2F59D40D
GO
Isoform 4AB (identifier: O60716-26) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.
     626-631: Missing.

Show »
Length:639
Mass (Da):71,225
Checksum:iF45EA4D758555CE3
GO
Isoform 4AC (identifier: O60716-27) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.
     937-965: Missing.

Show »
Length:616
Mass (Da):68,852
Checksum:iE1014C183DAFB90D
GO
Isoform 4BC (identifier: O60716-28) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.
     880-900: Missing.

Show »
Length:624
Mass (Da):69,655
Checksum:iEEDFAEC10BE108A5
GO
Isoform 4A (identifier: O60716-29) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.
     626-631: Missing.
     937-965: Missing.

Show »
Length:610
Mass (Da):68,031
Checksum:i402B89CAE47E6A8E
GO
Isoform 4B (identifier: O60716-30) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.
     626-631: Missing.
     880-900: Missing.

Show »
Length:618
Mass (Da):68,834
Checksum:iAE57FD1DC87F15AF
GO
Isoform 4C (identifier: O60716-31) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.
     880-900: Missing.
     937-965: Missing.

Show »
Length:595
Mass (Da):66,461
Checksum:iC93D22BB614EA62B
GO
Isoform 4 (identifier: O60716-32) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.
     626-631: Missing.
     880-900: Missing.
     937-965: Missing.

Show »
Length:589
Mass (Da):65,641
Checksum:i34C9A6E2B5944D2C
GO

Sequence cautioni

The sequence BAA20838 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti319R → M in BAA20838 (PubMed:9205841).Curated1
Sequence conflicti380D → G in AAH75795 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038255171S → F.Corresponds to variant rs11229133dbSNPEnsembl.1
Natural variantiVAR_020929217Y → C.1 PublicationCorresponds to variant rs11570194dbSNPEnsembl.1
Natural variantiVAR_020930464R → C.1 PublicationCorresponds to variant rs11570199dbSNPEnsembl.1
Natural variantiVAR_020931915R → K.1 PublicationCorresponds to variant rs11570222dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0067421 – 323Missing in isoform 4ABC, isoform 4AB, isoform 4AC, isoform 4BC, isoform 4A, isoform 4B, isoform 4C and isoform 4. CuratedAdd BLAST323
Alternative sequenceiVSP_0067411 – 101Missing in isoform 3ABC, isoform 3AB, isoform 3AC, isoform 3BC, isoform 3A, isoform 3B, isoform 3C and isoform 3. CuratedAdd BLAST101
Alternative sequenceiVSP_0067401 – 54Missing in isoform 2ABC, isoform 2AB, isoform 2AC, isoform 2BC, isoform 2A, isoform 2B, isoform 2C and isoform 2. CuratedAdd BLAST54
Alternative sequenceiVSP_006743626 – 631Missing in isoform 1AB, isoform 1A, isoform 1B, isoform 1, isoform 2AB, isoform 2A, isoform 2B, isoform 2, isoform 3AB, isoform 3A, isoform 3B, isoform 3, isoform 4AB, isoform 4A, isoform 4B and isoform 4. 1 Publication6
Alternative sequenceiVSP_006744880 – 900Missing in isoform 1BC, isoform 1B, isoform 1C, isoform 1, isoform 2BC, isoform 2B, isoform 2C, isoform 2, isoform 3BC, isoform 3B, isoform 3C, isoform 3, isoform 4BC, isoform 4B, isoform 4C and isoform 4. CuratedAdd BLAST21
Alternative sequenceiVSP_006745937 – 965Missing in isoform 1AC, isoform 1A, isoform 1C, isoform 1, isoform 2AC, isoform 2A, isoform 2C, isoform 2, isoform 3AC, isoform 3A, isoform 3C, isoform 3, isoform 4AC, isoform 4A, isoform 4C and isoform 4. 3 PublicationsAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF062319 mRNA. Translation: AAC39804.1.
AF062323 mRNA. Translation: AAC39808.1.
AF062341 mRNA. Translation: AAC39826.1.
AF062342 mRNA. Translation: AAC39827.1.
AF062322 mRNA. Translation: AAC39807.1.
AF062326 mRNA. Translation: AAC39811.1.
AF062328 mRNA. Translation: AAC39813.1.
AF062338 mRNA. Translation: AAC39823.1.
AF062324 mRNA. Translation: AAC39809.1.
AF062327 mRNA. Translation: AAC39812.1.
AF062329 mRNA. Translation: AAC39814.1.
AF062330 mRNA. Translation: AAC39815.1.
AF062331 mRNA. Translation: AAC39816.1.
AF062333 mRNA. Translation: AAC39818.1.
AF062334 mRNA. Translation: AAC39819.1.
AF062335 mRNA. Translation: AAC39820.1.
AF062336 mRNA. Translation: AAC39821.1.
AF062339 mRNA. Translation: AAC39824.1.
AF062340 mRNA. Translation: AAC39825.1.
AF062343 mRNA. Translation: AAC39828.1.
AF062317 mRNA. Translation: AAC39802.1.
AF062325 mRNA. Translation: AAC39810.1.
AF062332 mRNA. Translation: AAC39817.1.
AF062344 mRNA. Translation: AAC39829.1.
AF062321 mRNA. Translation: AAC39806.1.
AF062320 mRNA. Translation: AAC39805.1.
AF062337 mRNA. Translation: AAC39822.1.
AF062318 mRNA. Translation: AAC39803.1.
AB002382 mRNA. Translation: BAA20838.2. Different initiation.
AK292554 mRNA. Translation: BAF85243.1.
AY505564 Genomic DNA. Translation: AAR84236.1.
AP001931 Genomic DNA. No translation available.
BC075795 mRNA. Translation: AAH75795.1.
CCDSiCCDS44604.1. [O60716-1]
CCDS44605.1. [O60716-2]
CCDS44606.1. [O60716-5]
CCDS44607.1. [O60716-6]
CCDS44608.1. [O60716-17]
CCDS44609.1. [O60716-21]
CCDS53632.1. [O60716-19]
CCDS53633.1. [O60716-18]
CCDS53634.1. [O60716-22]
CCDS55763.1. [O60716-9]
CCDS55764.1. [O60716-11]
CCDS55765.1. [O60716-10]
CCDS55766.1. [O60716-13]
CCDS55767.1. [O60716-14]
CCDS73290.1. [O60716-3]
RefSeqiNP_001078927.1. NM_001085458.1. [O60716-1]
NP_001078928.1. NM_001085459.1. [O60716-2]
NP_001078929.1. NM_001085460.1. [O60716-5]
NP_001078930.1. NM_001085461.1. [O60716-5]
NP_001078931.1. NM_001085462.1. [O60716-5]
NP_001078932.1. NM_001085463.1. [O60716-17]
NP_001078933.1. NM_001085464.1. [O60716-18]
NP_001078934.1. NM_001085465.1. [O60716-22]
NP_001078935.1. NM_001085466.1. [O60716-19]
NP_001078936.1. NM_001085467.1. [O60716-21]
NP_001078937.1. NM_001085468.1. [O60716-21]
NP_001078938.1. NM_001085469.1. [O60716-21]
NP_001193812.1. NM_001206883.1. [O60716-9]
NP_001193813.1. NM_001206884.1. [O60716-11]
NP_001193814.1. NM_001206885.1. [O60716-3]
NP_001193815.1. NM_001206886.1. [O60716-10]
NP_001193816.1. NM_001206887.1. [O60716-14]
NP_001193817.1. NM_001206888.1. [O60716-13]
NP_001193818.1. NM_001206889.1. [O60716-13]
NP_001193819.1. NM_001206890.1. [O60716-21]
NP_001193820.1. NM_001206891.1. [O60716-13]
NP_001322.1. NM_001331.2. [O60716-6]
UniGeneiHs.166011.

Genome annotation databases

EnsembliENST00000358694; ENSP00000351527; ENSG00000198561. [O60716-5]
ENST00000361332; ENSP00000354823; ENSG00000198561. [O60716-2]
ENST00000361391; ENSP00000354785; ENSG00000198561. [O60716-6]
ENST00000361796; ENSP00000354907; ENSG00000198561. [O60716-3]
ENST00000399050; ENSP00000382004; ENSG00000198561. [O60716-1]
ENST00000415361; ENSP00000403518; ENSG00000198561. [O60716-17]
ENST00000426142; ENSP00000409930; ENSG00000198561. [O60716-21]
ENST00000428599; ENSP00000413586; ENSG00000198561. [O60716-5]
ENST00000524630; ENSP00000436543; ENSG00000198561. [O60716-5]
ENST00000525902; ENSP00000434672; ENSG00000198561. [O60716-27]
ENST00000526357; ENSP00000433334; ENSG00000198561. [O60716-10]
ENST00000526772; ENSP00000433158; ENSG00000198561. [O60716-29]
ENST00000526938; ENSP00000432041; ENSG00000198561. [O60716-7]
ENST00000527467; ENSP00000434900; ENSG00000198561. [O60716-25]
ENST00000528232; ENSP00000435266; ENSG00000198561. [O60716-19]
ENST00000528621; ENSP00000432243; ENSG00000198561. [O60716-13]
ENST00000529526; ENSP00000436323; ENSG00000198561. [O60716-13]
ENST00000529873; ENSP00000435494; ENSG00000198561. [O60716-14]
ENST00000529986; ENSP00000437156; ENSG00000198561. [O60716-21]
ENST00000530094; ENSP00000437327; ENSG00000198561. [O60716-18]
ENST00000530748; ENSP00000436744; ENSG00000198561. [O60716-11]
ENST00000531014; ENSP00000432623; ENSG00000198561. [O60716-26]
ENST00000532245; ENSP00000434017; ENSG00000198561. [O60716-21]
ENST00000532463; ENSP00000432075; ENSG00000198561. [O60716-21]
ENST00000532649; ENSP00000435379; ENSG00000198561. [O60716-13]
ENST00000532787; ENSP00000434949; ENSG00000198561. [O60716-22]
ENST00000532844; ENSP00000433276; ENSG00000198561. [O60716-9]
ENST00000533667; ENSP00000437051; ENSG00000198561. [O60716-30]
ENST00000534579; ENSP00000435789; ENSG00000198561. [O60716-13]
GeneIDi1500.
KEGGihsa:1500.
UCSCiuc001nli.5. human. [O60716-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF062319 mRNA. Translation: AAC39804.1.
AF062323 mRNA. Translation: AAC39808.1.
AF062341 mRNA. Translation: AAC39826.1.
AF062342 mRNA. Translation: AAC39827.1.
AF062322 mRNA. Translation: AAC39807.1.
AF062326 mRNA. Translation: AAC39811.1.
AF062328 mRNA. Translation: AAC39813.1.
AF062338 mRNA. Translation: AAC39823.1.
AF062324 mRNA. Translation: AAC39809.1.
AF062327 mRNA. Translation: AAC39812.1.
AF062329 mRNA. Translation: AAC39814.1.
AF062330 mRNA. Translation: AAC39815.1.
AF062331 mRNA. Translation: AAC39816.1.
AF062333 mRNA. Translation: AAC39818.1.
AF062334 mRNA. Translation: AAC39819.1.
AF062335 mRNA. Translation: AAC39820.1.
AF062336 mRNA. Translation: AAC39821.1.
AF062339 mRNA. Translation: AAC39824.1.
AF062340 mRNA. Translation: AAC39825.1.
AF062343 mRNA. Translation: AAC39828.1.
AF062317 mRNA. Translation: AAC39802.1.
AF062325 mRNA. Translation: AAC39810.1.
AF062332 mRNA. Translation: AAC39817.1.
AF062344 mRNA. Translation: AAC39829.1.
AF062321 mRNA. Translation: AAC39806.1.
AF062320 mRNA. Translation: AAC39805.1.
AF062337 mRNA. Translation: AAC39822.1.
AF062318 mRNA. Translation: AAC39803.1.
AB002382 mRNA. Translation: BAA20838.2. Different initiation.
AK292554 mRNA. Translation: BAF85243.1.
AY505564 Genomic DNA. Translation: AAR84236.1.
AP001931 Genomic DNA. No translation available.
BC075795 mRNA. Translation: AAH75795.1.
CCDSiCCDS44604.1. [O60716-1]
CCDS44605.1. [O60716-2]
CCDS44606.1. [O60716-5]
CCDS44607.1. [O60716-6]
CCDS44608.1. [O60716-17]
CCDS44609.1. [O60716-21]
CCDS53632.1. [O60716-19]
CCDS53633.1. [O60716-18]
CCDS53634.1. [O60716-22]
CCDS55763.1. [O60716-9]
CCDS55764.1. [O60716-11]
CCDS55765.1. [O60716-10]
CCDS55766.1. [O60716-13]
CCDS55767.1. [O60716-14]
CCDS73290.1. [O60716-3]
RefSeqiNP_001078927.1. NM_001085458.1. [O60716-1]
NP_001078928.1. NM_001085459.1. [O60716-2]
NP_001078929.1. NM_001085460.1. [O60716-5]
NP_001078930.1. NM_001085461.1. [O60716-5]
NP_001078931.1. NM_001085462.1. [O60716-5]
NP_001078932.1. NM_001085463.1. [O60716-17]
NP_001078933.1. NM_001085464.1. [O60716-18]
NP_001078934.1. NM_001085465.1. [O60716-22]
NP_001078935.1. NM_001085466.1. [O60716-19]
NP_001078936.1. NM_001085467.1. [O60716-21]
NP_001078937.1. NM_001085468.1. [O60716-21]
NP_001078938.1. NM_001085469.1. [O60716-21]
NP_001193812.1. NM_001206883.1. [O60716-9]
NP_001193813.1. NM_001206884.1. [O60716-11]
NP_001193814.1. NM_001206885.1. [O60716-3]
NP_001193815.1. NM_001206886.1. [O60716-10]
NP_001193816.1. NM_001206887.1. [O60716-14]
NP_001193817.1. NM_001206888.1. [O60716-13]
NP_001193818.1. NM_001206889.1. [O60716-13]
NP_001193819.1. NM_001206890.1. [O60716-21]
NP_001193820.1. NM_001206891.1. [O60716-13]
NP_001322.1. NM_001331.2. [O60716-6]
UniGeneiHs.166011.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3L6XX-ray2.40A324-937[»]
3L6YX-ray3.00A/C/E324-937[»]
ProteinModelPortaliO60716.
SMRiO60716.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107881. 55 interactors.
DIPiDIP-33850N.
IntActiO60716. 41 interactors.
MINTiMINT-4999228.
STRINGi9606.ENSP00000382004.

PTM databases

iPTMnetiO60716.
PhosphoSitePlusiO60716.
SwissPalmiO60716.

Polymorphism and mutation databases

BioMutaiCTNND1.

Proteomic databases

EPDiO60716.
MaxQBiO60716.
PaxDbiO60716.
PeptideAtlasiO60716.
PRIDEiO60716.

Protocols and materials databases

DNASUi1500.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358694; ENSP00000351527; ENSG00000198561. [O60716-5]
ENST00000361332; ENSP00000354823; ENSG00000198561. [O60716-2]
ENST00000361391; ENSP00000354785; ENSG00000198561. [O60716-6]
ENST00000361796; ENSP00000354907; ENSG00000198561. [O60716-3]
ENST00000399050; ENSP00000382004; ENSG00000198561. [O60716-1]
ENST00000415361; ENSP00000403518; ENSG00000198561. [O60716-17]
ENST00000426142; ENSP00000409930; ENSG00000198561. [O60716-21]
ENST00000428599; ENSP00000413586; ENSG00000198561. [O60716-5]
ENST00000524630; ENSP00000436543; ENSG00000198561. [O60716-5]
ENST00000525902; ENSP00000434672; ENSG00000198561. [O60716-27]
ENST00000526357; ENSP00000433334; ENSG00000198561. [O60716-10]
ENST00000526772; ENSP00000433158; ENSG00000198561. [O60716-29]
ENST00000526938; ENSP00000432041; ENSG00000198561. [O60716-7]
ENST00000527467; ENSP00000434900; ENSG00000198561. [O60716-25]
ENST00000528232; ENSP00000435266; ENSG00000198561. [O60716-19]
ENST00000528621; ENSP00000432243; ENSG00000198561. [O60716-13]
ENST00000529526; ENSP00000436323; ENSG00000198561. [O60716-13]
ENST00000529873; ENSP00000435494; ENSG00000198561. [O60716-14]
ENST00000529986; ENSP00000437156; ENSG00000198561. [O60716-21]
ENST00000530094; ENSP00000437327; ENSG00000198561. [O60716-18]
ENST00000530748; ENSP00000436744; ENSG00000198561. [O60716-11]
ENST00000531014; ENSP00000432623; ENSG00000198561. [O60716-26]
ENST00000532245; ENSP00000434017; ENSG00000198561. [O60716-21]
ENST00000532463; ENSP00000432075; ENSG00000198561. [O60716-21]
ENST00000532649; ENSP00000435379; ENSG00000198561. [O60716-13]
ENST00000532787; ENSP00000434949; ENSG00000198561. [O60716-22]
ENST00000532844; ENSP00000433276; ENSG00000198561. [O60716-9]
ENST00000533667; ENSP00000437051; ENSG00000198561. [O60716-30]
ENST00000534579; ENSP00000435789; ENSG00000198561. [O60716-13]
GeneIDi1500.
KEGGihsa:1500.
UCSCiuc001nli.5. human. [O60716-1]

Organism-specific databases

CTDi1500.
DisGeNETi1500.
GeneCardsiCTNND1.
HGNCiHGNC:2515. CTNND1.
HPAiCAB003837.
HPA015954.
HPA015955.
MIMi601045. gene.
neXtProtiNX_O60716.
OpenTargetsiENSG00000198561.
PharmGKBiPA27016.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1048. Eukaryota.
ENOG410Y21Q. LUCA.
GeneTreeiENSGT00760000119167.
HOVERGENiHBG004284.
InParanoidiO60716.
KOiK05690.
OMAiQYYWAPL.
OrthoDBiEOG091G018C.
PhylomeDBiO60716.
TreeFamiTF321877.

Enzyme and pathway databases

BioCyciZFISH:G66-32089-MONOMER.
ReactomeiR-HSA-418990. Adherens junctions interactions.
R-HSA-5218920. VEGFR2 mediated vascular permeability.
SignaLinkiO60716.
SIGNORiO60716.

Miscellaneous databases

ChiTaRSiCTNND1. human.
EvolutionaryTraceiO60716.
GeneWikiiCTNND1.
GenomeRNAii1500.
PROiO60716.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198561.
ExpressionAtlasiO60716. baseline and differential.
GenevisibleiO60716. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028439. Catenin_d1.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 1 hit.
PTHR10372:SF6. PTHR10372:SF6. 1 hit.
PfamiPF00514. Arm. 3 hits.
[Graphical view]
SMARTiSM00185. ARM. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTND1_HUMAN
AccessioniPrimary (citable) accession number: O60716
Secondary accession number(s): A8K939
, O15088, O60713, O60714, O60715, O60935, Q6DHZ7, Q6RBX8, Q9UP71, Q9UP72, Q9UP73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 168 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.