O60716 (CTND1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Catenin delta-1

Alternative name(s):
Cadherin-associated Src substrate
Short name=CAS
p120 catenin
Short name=p120(ctn)
p120(cas)

Gene names

Name:	CTNND1
Synonyms:	KIAA0384

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	968 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway By similarity. May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage. Ref.19
Subunit structure	Belongs to a multiprotein cell-cell adhesion complex that also contains E-cadherin, alpha-catenin, beta-catenin, and gamma-catenin. Binds to the C-terminal fragment of PSEN1 and mutually competes for E-cadherin. Interacts with ZBTB33. Interacts with GLIS2. Interacts with NANOS1 (via N-terminal region). Interacts with FER. Ref.7 Ref.8 Ref.15 Ref.19
Subcellular location	Cytoplasm. Nucleus. Cell membrane. Note: Interaction with GLIS2 promotes nuclear translocation By similarity. Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm. Ref.15 Ref.17
Tissue specificity	Expressed in vascular endothelium. Ref.10
Induction	Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress, which enhances wound closure. Ref.10
Domain	A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.
Post-translational modification	Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK7/PAK5. Dephosphorylated by PTPRJ. Ref.7 Ref.9 Ref.11 Ref.12 Ref.13 Ref.14 Ref.16 Ref.18 Ref.20 Ref.21 Ref.22 Ref.23 Ref.24 Ref.25 Ref.26
Sequence similarities	Belongs to the beta-catenin family. Contains 10 ARM repeats.
Sequence caution	The sequence BAA20838.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Cell adhesion Transcription Transcription regulation Wnt signaling pathway
Cellular component	Cell membrane Cytoplasm Membrane Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW adherens junction organization Traceable author statement. Source: Reactome cell junction assembly Traceable author statement. Source: Reactome negative regulation of canonical Wnt receptor signaling pathway Inferred from mutant phenotype. Source: BHF-UCL regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytosol Inferred from mutant phenotype. Source: BHF-UCL midbody Inferred from direct assay. Source: UniProtKB nucleus Inferred from direct assay. Source: BHF-UCL plasma membrane Inferred from direct assay Ref.17. Source: UniProtKB
Molecular function	cadherin binding Inferred from physical interaction. Source: UniProtKB protein binding Inferred from physical interaction. Source: IntAct receptor binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Cdh1	P09803	3	EBI-702059,EBI-984420	From a different organism.

Alternative products

This entry describes 32 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1ABC (identifier: O60716-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1AB (identifier: O60716-2)

The sequence of this isoform differs from the canonical sequence as follows:
     626-631: Missing.

Isoform 1AC (identifier: O60716-3)

The sequence of this isoform differs from the canonical sequence as follows:
     937-965: Missing.

Isoform 1BC (identifier: O60716-4)

The sequence of this isoform differs from the canonical sequence as follows:
     881-900: Missing.

Isoform 1A (identifier: O60716-5)

The sequence of this isoform differs from the canonical sequence as follows:
     626-631: Missing.
     937-965: Missing.

Isoform 1B (identifier: O60716-6)

The sequence of this isoform differs from the canonical sequence as follows:
     626-631: Missing.
     881-900: Missing.

Isoform 1C (identifier: O60716-7)

The sequence of this isoform differs from the canonical sequence as follows:
     881-900: Missing.
     937-965: Missing.

Isoform 1 (identifier: O60716-8)

The sequence of this isoform differs from the canonical sequence as follows:
     626-631: Missing.
     881-900: Missing.
     937-965: Missing.

Isoform 2ABC (identifier: O60716-9)

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.

Isoform 2AB (identifier: O60716-10)

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
     626-631: Missing.

Isoform 2AC (identifier: O60716-11)

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
     937-965: Missing.

Isoform 2BC (identifier: O60716-12)

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
     881-900: Missing.

Isoform 2A (identifier: O60716-13)

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
     626-631: Missing.
     937-965: Missing.

Isoform 2B (identifier: O60716-14)

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
     626-631: Missing.
     881-900: Missing.

Isoform 2C (identifier: O60716-15)

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
     881-900: Missing.
     937-965: Missing.

Isoform 2 (identifier: O60716-16)

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
     626-631: Missing.
     881-900: Missing.
     937-965: Missing.

Isoform 3ABC (identifier: O60716-17)

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.

Isoform 3AB (identifier: O60716-18)

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     626-631: Missing.

Isoform 3AC (identifier: O60716-19)

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     937-965: Missing.

Isoform 3BC (identifier: O60716-20)

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     881-900: Missing.

Isoform 3A (identifier: O60716-21)

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     626-631: Missing.
     937-965: Missing.

Isoform 3B (identifier: O60716-22)

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     626-631: Missing.
     881-900: Missing.

Isoform 3C (identifier: O60716-23)

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     881-900: Missing.
     937-965: Missing.

Isoform 3 (identifier: O60716-24)

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     626-631: Missing.
     881-900: Missing.
     937-965: Missing.

Isoform 4ABC (identifier: O60716-25)

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.

Isoform 4AB (identifier: O60716-26)

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.
     626-631: Missing.

Isoform 4AC (identifier: O60716-27)

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.
     937-965: Missing.

Isoform 4BC (identifier: O60716-28)

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.
     881-900: Missing.

Isoform 4A (identifier: O60716-29)

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.
     626-631: Missing.
     937-965: Missing.

Isoform 4B (identifier: O60716-30)

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.
     626-631: Missing.
     881-900: Missing.

Isoform 4C (identifier: O60716-31)

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.
     881-900: Missing.
     937-965: Missing.

Isoform 4 (identifier: O60716-32)

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.
     626-631: Missing.
     881-900: Missing.
     937-965: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 968

968

Catenin delta-1

PRO_0000064296

Regions

Repeat

358 – 395

38

ARM 1

Repeat

398 – 437

40

ARM 2

Repeat

441 – 475

35

ARM 3

Repeat

476 – 516

41

ARM 4

Repeat

534 – 573

40

ARM 5

Repeat

583 – 624

42

ARM 6

Repeat

653 – 693

41

ARM 7

Repeat

700 – 739

40

ARM 8

Repeat

740 – 780

41

ARM 9

Repeat

781 – 826

46

ARM 10

Coiled coil

10 – 46

37

Potential

Motif

622 – 634

13

Nuclear localization signal By similarity

Amino acid modifications

Modified residue

47

1

Phosphoserine Ref.16 Ref.23

Modified residue

96

1

Phosphotyrosine Ref.12 Ref.18 Ref.25

Modified residue

112

1

Phosphotyrosine; by FYN Ref.20

Modified residue

174

1

Phosphotyrosine Ref.12 Ref.21 Ref.25

Modified residue

193

1

Phosphotyrosine Ref.25

Modified residue

208

1

Phosphotyrosine Ref.21

Modified residue

213

1

Phosphotyrosine Ref.21 Ref.25

Modified residue

217

1

Phosphotyrosine Ref.12 Ref.14 Ref.21

Modified residue

228

1

Phosphotyrosine Ref.12 Ref.14 Ref.16 Ref.21 Ref.22 Ref.25

Modified residue

230

1

Phosphoserine Ref.22 Ref.23

Modified residue

232

1

Phosphoserine Ref.22

Modified residue

244

1

Phosphoserine Ref.22

Modified residue

248

1

Phosphotyrosine Ref.25

Modified residue

252

1

Phosphoserine By similarity

Modified residue

257

1

Phosphotyrosine Ref.12 Ref.14 Ref.18 Ref.21 Ref.25

Modified residue

268

1

Phosphoserine Ref.16 Ref.24

Modified residue

269

1

Phosphoserine Ref.16 Ref.24

Modified residue

280

1

Phosphotyrosine Ref.14 Ref.21 Ref.25

Modified residue

288

1

Phosphoserine; by PAK7/PAK5 Ref.22 Ref.23 Ref.26

Modified residue

291

1

Phosphotyrosine By similarity

Modified residue

302

1

Phosphotyrosine Ref.12

Modified residue

310

1

Phosphothreonine Ref.16

Modified residue

320

1

Phosphoserine By similarity

Modified residue

321

1

Phosphotyrosine Ref.13 Ref.16

Modified residue

334

1

Phosphotyrosine Ref.13

Modified residue

346

1

Phosphoserine By similarity

Modified residue

349

1

Phosphoserine Ref.11 Ref.16 Ref.24

Modified residue

352

1

Phosphoserine Ref.11 Ref.16 Ref.24

Modified residue

857

1

Phosphoserine By similarity

Modified residue

859

1

Phosphoserine By similarity

Modified residue

864

1

Phosphoserine By similarity

Modified residue

865

1

Phosphotyrosine Ref.12

Modified residue

869

1

Phosphothreonine Ref.22

Modified residue

904

1

Phosphotyrosine Ref.18 Ref.25

Modified residue

916

1

Phosphothreonine Ref.16

Modified residue

920

1

Phosphoserine By similarity

Natural variations

Alternative sequence

1 – 323

323

Missing in isoform 4ABC, isoform 4AB, isoform 4AC, isoform 4BC, isoform 4A, isoform 4B, isoform 4C and isoform 4.

VSP_006742

Alternative sequence

1 – 101

101

Missing in isoform 3ABC, isoform 3AB, isoform 3AC, isoform 3BC, isoform 3A, isoform 3B, isoform 3C and isoform 3.

VSP_006741

Alternative sequence

1 – 54

54

Missing in isoform 2ABC, isoform 2AB, isoform 2AC, isoform 2BC, isoform 2A, isoform 2B, isoform 2C and isoform 2.

VSP_006740

Alternative sequence

626 – 631

6

Missing in isoform 1AB, isoform 1A, isoform 1B, isoform 1, isoform 2AB, isoform 2A, isoform 2B, isoform 2, isoform 3AB, isoform 3A, isoform 3B, isoform 3, isoform 4AB, isoform 4A, isoform 4B and isoform 4.

VSP_006743

Alternative sequence

881 – 900

20

Missing in isoform 1BC, isoform 1B, isoform 1C, isoform 1, isoform 2BC, isoform 2B, isoform 2C, isoform 2, isoform 3BC, isoform 3B, isoform 3C, isoform 3, isoform 4BC, isoform 4B, isoform 4C and isoform 4.

VSP_006744

Alternative sequence

937 – 965

29

Missing in isoform 1AC, isoform 1A, isoform 1C, isoform 1, isoform 2AC, isoform 2A, isoform 2C, isoform 2, isoform 3AC, isoform 3A, isoform 3C, isoform 3, isoform 4AC, isoform 4A, isoform 4C and isoform 4.

VSP_006745

Natural variant

171

1

S → F.
Corresponds to variant rs11229133 [ dbSNP | Ensembl ].

VAR_038255

Natural variant

217

1

Y → C. Ref.4
Corresponds to variant rs11570194 [ dbSNP | Ensembl ].

VAR_020929

Natural variant

464

1

R → C. Ref.4
Corresponds to variant rs11570199 [ dbSNP | Ensembl ].

VAR_020930

Natural variant

915

1

R → K. Ref.4
Corresponds to variant rs11570222 [ dbSNP | Ensembl ].

VAR_020931

Experimental info

Sequence conflict

319

1

R → M in BAA20838. Ref.2

Sequence conflict

380

1

D → G in AAH75795. Ref.6

Secondary structure

1

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968

Helix Strand Turn

Details...

Helix

368 – 374

7

Helix

380 – 394

15

Helix

398 – 406

9

Turn

411 – 413

3

Turn

417 – 419

3

Helix

422 – 425

4

Helix

432 – 435

4

Helix

441 – 449

9

Helix

454 – 462

9

Helix

466 – 472

7

Helix

476 – 479

4

Helix

483 – 485

3

Helix

486 – 492

7

Helix

494 – 500

7

Helix

502 – 505

4

Helix

524 – 530

7

Helix

534 – 537

4

Helix

542 – 550

9

Helix

555 – 565

11

Helix

574 – 587

14

Helix

590 – 593

4

Helix

657 – 660

4

Helix

662 – 674

13

Helix

678 – 684

7

Helix

688 – 692

5

Helix

701 – 706

6

Helix

709 – 717

9

Helix

718 – 720

3

Helix

724 – 730

7

Helix

734 – 738

5

Turn

744 – 746

3

Helix

752 – 757

6

Helix

766 – 768

3

Helix

772 – 786

15

Helix

790 – 798

9

Helix

803 – 809

7

Helix

816 – 829

14

Helix

833 – 840

8

Helix

846 – 849

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1ABC [UniParc]. Last modified August 1, 1998. Version 1. Checksum: D5C37489A891F292	FASTA	968	108,170
	10 20 30 40 50 60 MDDSEVESTA SILASVKEQE AQFEKLTRAL EEERRHVSAQ LERVRVSPQD ANPLMANGTL 70 80 90 100 110 120 TRRHQNGRFV GDADLERQKF SDLKLNGPQD HSHLLYSTIP RMQEPGQIVE TYTEEDPEGA 130 140 150 160 170 180 MSVVSVETSD DGTTRRTETT VKKVVKTVTT RTVQPVAMGP DGLPVDASSV SNNYIQTLGR 190 200 210 220 230 240 DFRKNGNGGP GPYVGQAGTA TLPRNFHYPP DGYSRHYEDG YPGGSDNYGS LSRVTRIEER 250 260 270 280 290 300 YRPSMEGYRA PSRQDVYGPQ PQVRVGGSSV DLHRFHPEPY GLEDDQRSMG YDDLDYGMMS 310 320 330 340 350 360 DYGTARRTGT PSDPRRRLRS YEDMIGEEVP SDQYYWAPLA QHERGSLASL DSLRKGGPPP 370 380 390 400 410 420 PNWRQPELPE VIAMLGFRLD AVKSNAAAYL QHLCYRNDKV KTDVRKLKGI PVLVGLLDHP 430 440 450 460 470 480 KKEVHLGACG ALKNISFGRD QDNKIAIKNC DGVPALVRLL RKARDMDLTE VITGTLWNLS 490 500 510 520 530 540 SHDSIKMEIV DHALHALTDE VIIPHSGWER EPNEDCKPRH IEWESVLTNT AGCLRNVSSE 550 560 570 580 590 600 RSEARRKLRE CDGLVDALIF IVQAEIGQKD SDSKLVENCV CLLRNLSYQV HREIPQAERY 610 620 630 640 650 660 QEAAPNVANN TGPHAASCFG AKKGKDEWFS RGKKPIEDPA NDTVDFPKRT SPARGYELLF 670 680 690 700 710 720 QPEVVRIYIS LLKESKTPAI LEASAGAIQN LCAGRWTYGR YIRSALRQEK ALSAIADLLT 730 740 750 760 770 780 NEHERVVKAA SGALRNLAVD ARNKELIGKH AIPNLVKNLP GGQQNSSWNF SEDTVISILN 790 800 810 820 830 840 TINEVIAENL EAAKKLRETQ GIEKLVLINK SGNRSEKEVR AAALVLQTIW GYKELRKPLE 850 860 870 880 890 900 KEGWKKSDFQ VNLNNASRSQ SSHSYDDSTL PLIDRNQKSD KKPDREEIQM SNMGSNTKSL 910 920 930 940 950 960 DNNYSTPNER GDHNRTLDRS GDLGDMEPLK GTTPLMQDEG QESLEEELDV LVLDDEGGQV SYPSMQKI
	Isoform 1AB [UniParc]. Checksum: 62C1AA58EC4ED712	FASTA	962	107,349
	10 20 30 40 50 60 MDDSEVESTA SILASVKEQE AQFEKLTRAL EEERRHVSAQ LERVRVSPQD ANPLMANGTL 70 80 90 100 110 120 TRRHQNGRFV GDADLERQKF SDLKLNGPQD HSHLLYSTIP RMQEPGQIVE TYTEEDPEGA 130 140 150 160 170 180 MSVVSVETSD DGTTRRTETT VKKVVKTVTT RTVQPVAMGP DGLPVDASSV SNNYIQTLGR 190 200 210 220 230 240 DFRKNGNGGP GPYVGQAGTA TLPRNFHYPP DGYSRHYEDG YPGGSDNYGS LSRVTRIEER 250 260 270 280 290 300 YRPSMEGYRA PSRQDVYGPQ PQVRVGGSSV DLHRFHPEPY GLEDDQRSMG YDDLDYGMMS 310 320 330 340 350 360 DYGTARRTGT PSDPRRRLRS YEDMIGEEVP SDQYYWAPLA QHERGSLASL DSLRKGGPPP 370 380 390 400 410 420 PNWRQPELPE VIAMLGFRLD AVKSNAAAYL QHLCYRNDKV KTDVRKLKGI PVLVGLLDHP 430 440 450 460 470 480 KKEVHLGACG ALKNISFGRD QDNKIAIKNC DGVPALVRLL RKARDMDLTE VITGTLWNLS 490 500 510 520 530 540 SHDSIKMEIV DHALHALTDE VIIPHSGWER EPNEDCKPRH IEWESVLTNT AGCLRNVSSE 550 560 570 580 590 600 RSEARRKLRE CDGLVDALIF IVQAEIGQKD SDSKLVENCV CLLRNLSYQV HREIPQAERY 610 620 630 640 650 660 QEAAPNVANN TGPHAASCFG AKKGKGKKPI EDPANDTVDF PKRTSPARGY ELLFQPEVVR 670 680 690 700 710 720 IYISLLKESK TPAILEASAG AIQNLCAGRW TYGRYIRSAL RQEKALSAIA DLLTNEHERV 730 740 750 760 770 780 VKAASGALRN LAVDARNKEL IGKHAIPNLV KNLPGGQQNS SWNFSEDTVI SILNTINEVI 790 800 810 820 830 840 AENLEAAKKL RETQGIEKLV LINKSGNRSE KEVRAAALVL QTIWGYKELR KPLEKEGWKK 850 860 870 880 890 900 SDFQVNLNNA SRSQSSHSYD DSTLPLIDRN QKSDKKPDRE EIQMSNMGSN TKSLDNNYST 910 920 930 940 950 960 PNERGDHNRT LDRSGDLGDM EPLKGTTPLM QDEGQESLEE ELDVLVLDDE GGQVSYPSMQ KI
	Isoform 1AC [UniParc]. Checksum: D436D996ECBEBDC7	FASTA	939	104,977
	10 20 30 40 50 60 MDDSEVESTA SILASVKEQE AQFEKLTRAL EEERRHVSAQ LERVRVSPQD ANPLMANGTL 70 80 90 100 110 120 TRRHQNGRFV GDADLERQKF SDLKLNGPQD HSHLLYSTIP RMQEPGQIVE TYTEEDPEGA 130 140 150 160 170 180 MSVVSVETSD DGTTRRTETT VKKVVKTVTT RTVQPVAMGP DGLPVDASSV SNNYIQTLGR 190 200 210 220 230 240 DFRKNGNGGP GPYVGQAGTA TLPRNFHYPP DGYSRHYEDG YPGGSDNYGS LSRVTRIEER 250 260 270 280 290 300 YRPSMEGYRA PSRQDVYGPQ PQVRVGGSSV DLHRFHPEPY GLEDDQRSMG YDDLDYGMMS 310 320 330 340 350 360 DYGTARRTGT PSDPRRRLRS YEDMIGEEVP SDQYYWAPLA QHERGSLASL DSLRKGGPPP 370 380 390 400 410 420 PNWRQPELPE VIAMLGFRLD AVKSNAAAYL QHLCYRNDKV KTDVRKLKGI PVLVGLLDHP 430 440 450 460 470 480 KKEVHLGACG ALKNISFGRD QDNKIAIKNC DGVPALVRLL RKARDMDLTE VITGTLWNLS 490 500 510 520 530 540 SHDSIKMEIV DHALHALTDE VIIPHSGWER EPNEDCKPRH IEWESVLTNT AGCLRNVSSE 550 560 570 580 590 600 RSEARRKLRE CDGLVDALIF IVQAEIGQKD SDSKLVENCV CLLRNLSYQV HREIPQAERY 610 620 630 640 650 660 QEAAPNVANN TGPHAASCFG AKKGKDEWFS RGKKPIEDPA NDTVDFPKRT SPARGYELLF 670 680 690 700 710 720 QPEVVRIYIS LLKESKTPAI LEASAGAIQN LCAGRWTYGR YIRSALRQEK ALSAIADLLT 730 740 750 760 770 780 NEHERVVKAA SGALRNLAVD ARNKELIGKH AIPNLVKNLP GGQQNSSWNF SEDTVISILN 790 800 810 820 830 840 TINEVIAENL EAAKKLRETQ GIEKLVLINK SGNRSEKEVR AAALVLQTIW GYKELRKPLE 850 860 870 880 890 900 KEGWKKSDFQ VNLNNASRSQ SSHSYDDSTL PLIDRNQKSD KKPDREEIQM SNMGSNTKSL 910 920 930 DNNYSTPNER GDHNRTLDRS GDLGDMEPLK GTTPLMQKI
	Isoform 1BC [UniParc]. Checksum: 8C4C0C4B6F742833	FASTA	948	105,894
	10 20 30 40 50 60 MDDSEVESTA SILASVKEQE AQFEKLTRAL EEERRHVSAQ LERVRVSPQD ANPLMANGTL 70 80 90 100 110 120 TRRHQNGRFV GDADLERQKF SDLKLNGPQD HSHLLYSTIP RMQEPGQIVE TYTEEDPEGA 130 140 150 160 170 180 MSVVSVETSD DGTTRRTETT VKKVVKTVTT RTVQPVAMGP DGLPVDASSV SNNYIQTLGR 190 200 210 220 230 240 DFRKNGNGGP GPYVGQAGTA TLPRNFHYPP DGYSRHYEDG YPGGSDNYGS LSRVTRIEER 250 260 270 280 290 300 YRPSMEGYRA PSRQDVYGPQ PQVRVGGSSV DLHRFHPEPY GLEDDQRSMG YDDLDYGMMS 310 320 330 340 350 360 DYGTARRTGT PSDPRRRLRS YEDMIGEEVP SDQYYWAPLA QHERGSLASL DSLRKGGPPP 370 380 390 400 410 420 PNWRQPELPE VIAMLGFRLD AVKSNAAAYL QHLCYRNDKV KTDVRKLKGI PVLVGLLDHP 430 440 450 460 470 480 KKEVHLGACG ALKNISFGRD QDNKIAIKNC DGVPALVRLL RKARDMDLTE VITGTLWNLS 490 500 510 520 530 540 SHDSIKMEIV DHALHALTDE VIIPHSGWER EPNEDCKPRH IEWESVLTNT AGCLRNVSSE 550 560 570 580 590 600 RSEARRKLRE CDGLVDALIF IVQAEIGQKD SDSKLVENCV CLLRNLSYQV HREIPQAERY 610 620 630 640 650 660 QEAAPNVANN TGPHAASCFG AKKGKDEWFS RGKKPIEDPA NDTVDFPKRT SPARGYELLF 670 680 690 700 710 720 QPEVVRIYIS LLKESKTPAI LEASAGAIQN LCAGRWTYGR YIRSALRQEK ALSAIADLLT 730 740 750 760 770 780 NEHERVVKAA SGALRNLAVD ARNKELIGKH AIPNLVKNLP GGQQNSSWNF SEDTVISILN 790 800 810 820 830 840 TINEVIAENL EAAKKLRETQ GIEKLVLINK SGNRSEKEVR AAALVLQTIW GYKELRKPLE 850 860 870 880 890 900 KEGWKKSDFQ VNLNNASRSQ SSHSYDDSTL PLIDRNQKSD DNNYSTPNER GDHNRTLDRS 910 920 930 940 GDLGDMEPLK GTTPLMQDEG QESLEEELDV LVLDDEGGQV SYPSMQKI
	Isoform 1A [UniParc]. Checksum: A4E1ABA2FE3D6B54	FASTA	933	104,156
	10 20 30 40 50 60 MDDSEVESTA SILASVKEQE AQFEKLTRAL EEERRHVSAQ LERVRVSPQD ANPLMANGTL 70 80 90 100 110 120 TRRHQNGRFV GDADLERQKF SDLKLNGPQD HSHLLYSTIP RMQEPGQIVE TYTEEDPEGA 130 140 150 160 170 180 MSVVSVETSD DGTTRRTETT VKKVVKTVTT RTVQPVAMGP DGLPVDASSV SNNYIQTLGR 190 200 210 220 230 240 DFRKNGNGGP GPYVGQAGTA TLPRNFHYPP DGYSRHYEDG YPGGSDNYGS LSRVTRIEER 250 260 270 280 290 300 YRPSMEGYRA PSRQDVYGPQ PQVRVGGSSV DLHRFHPEPY GLEDDQRSMG YDDLDYGMMS 310 320 330 340 350 360 DYGTARRTGT PSDPRRRLRS YEDMIGEEVP SDQYYWAPLA QHERGSLASL DSLRKGGPPP 370 380 390 400 410 420 PNWRQPELPE VIAMLGFRLD AVKSNAAAYL QHLCYRNDKV KTDVRKLKGI PVLVGLLDHP 430 440 450 460 470 480 KKEVHLGACG ALKNISFGRD QDNKIAIKNC DGVPALVRLL RKARDMDLTE VITGTLWNLS 490 500 510 520 530 540 SHDSIKMEIV DHALHALTDE VIIPHSGWER EPNEDCKPRH IEWESVLTNT AGCLRNVSSE 550 560 570 580 590 600 RSEARRKLRE CDGLVDALIF IVQAEIGQKD SDSKLVENCV CLLRNLSYQV HREIPQAERY 610 620 630 640 650 660 QEAAPNVANN TGPHAASCFG AKKGKGKKPI EDPANDTVDF PKRTSPARGY ELLFQPEVVR 670 680 690 700 710 720 IYISLLKESK TPAILEASAG AIQNLCAGRW TYGRYIRSAL RQEKALSAIA DLLTNEHERV 730 740 750 760 770 780 VKAASGALRN LAVDARNKEL IGKHAIPNLV KNLPGGQQNS SWNFSEDTVI SILNTINEVI 790 800 810 820 830 840 AENLEAAKKL RETQGIEKLV LINKSGNRSE KEVRAAALVL QTIWGYKELR KPLEKEGWKK 850 860 870 880 890 900 SDFQVNLNNA SRSQSSHSYD DSTLPLIDRN QKSDKKPDRE EIQMSNMGSN TKSLDNNYST 910 920 930 PNERGDHNRT LDRSGDLGDM EPLKGTTPLM QKI
	Isoform 1B [UniParc]. Checksum: D712A71924AC9249	FASTA	942	105,074
	10 20 30 40 50 60 MDDSEVESTA SILASVKEQE AQFEKLTRAL EEERRHVSAQ LERVRVSPQD ANPLMANGTL 70 80 90 100 110 120 TRRHQNGRFV GDADLERQKF SDLKLNGPQD HSHLLYSTIP RMQEPGQIVE TYTEEDPEGA 130 140 150 160 170 180 MSVVSVETSD DGTTRRTETT VKKVVKTVTT RTVQPVAMGP DGLPVDASSV SNNYIQTLGR 190 200 210 220 230 240 DFRKNGNGGP GPYVGQAGTA TLPRNFHYPP DGYSRHYEDG YPGGSDNYGS LSRVTRIEER 250 260 270 280 290 300 YRPSMEGYRA PSRQDVYGPQ PQVRVGGSSV DLHRFHPEPY GLEDDQRSMG YDDLDYGMMS 310 320 330 340 350 360 DYGTARRTGT PSDPRRRLRS YEDMIGEEVP SDQYYWAPLA QHERGSLASL DSLRKGGPPP 370 380 390 400 410 420 PNWRQPELPE VIAMLGFRLD AVKSNAAAYL QHLCYRNDKV KTDVRKLKGI PVLVGLLDHP 430 440 450 460 470 480 KKEVHLGACG ALKNISFGRD QDNKIAIKNC DGVPALVRLL RKARDMDLTE VITGTLWNLS 490 500 510 520 530 540 SHDSIKMEIV DHALHALTDE VIIPHSGWER EPNEDCKPRH IEWESVLTNT AGCLRNVSSE 550 560 570 580 590 600 RSEARRKLRE CDGLVDALIF IVQAEIGQKD SDSKLVENCV CLLRNLSYQV HREIPQAERY 610 620 630 640 650 660 QEAAPNVANN TGPHAASCFG AKKGKGKKPI EDPANDTVDF PKRTSPARGY ELLFQPEVVR 670 680 690 700 710 720 IYISLLKESK TPAILEASAG AIQNLCAGRW TYGRYIRSAL RQEKALSAIA DLLTNEHERV 730 740 750 760 770 780 VKAASGALRN LAVDARNKEL IGKHAIPNLV KNLPGGQQNS SWNFSEDTVI SILNTINEVI 790 800 810 820 830 840 AENLEAAKKL RETQGIEKLV LINKSGNRSE KEVRAAALVL QTIWGYKELR KPLEKEGWKK 850 860 870 880 890 900 SDFQVNLNNA SRSQSSHSYD DSTLPLIDRN QKSDDNNYST PNERGDHNRT LDRSGDLGDM 910 920 930 940 EPLKGTTPLM QDEGQESLEE ELDVLVLDDE GGQVSYPSMQ KI
	Isoform 1C [UniParc]. Checksum: 3064281A404F0742	FASTA	919	102,701
	10 20 30 40 50 60 MDDSEVESTA SILASVKEQE AQFEKLTRAL EEERRHVSAQ LERVRVSPQD ANPLMANGTL 70 80 90 100 110 120 TRRHQNGRFV GDADLERQKF SDLKLNGPQD HSHLLYSTIP RMQEPGQIVE TYTEEDPEGA 130 140 150 160 170 180 MSVVSVETSD DGTTRRTETT VKKVVKTVTT RTVQPVAMGP DGLPVDASSV SNNYIQTLGR 190 200 210 220 230 240 DFRKNGNGGP GPYVGQAGTA TLPRNFHYPP DGYSRHYEDG YPGGSDNYGS LSRVTRIEER 250 260 270 280 290 300 YRPSMEGYRA PSRQDVYGPQ PQVRVGGSSV DLHRFHPEPY GLEDDQRSMG YDDLDYGMMS 310 320 330 340 350 360 DYGTARRTGT PSDPRRRLRS YEDMIGEEVP SDQYYWAPLA QHERGSLASL DSLRKGGPPP 370 380 390 400 410 420 PNWRQPELPE VIAMLGFRLD AVKSNAAAYL QHLCYRNDKV KTDVRKLKGI PVLVGLLDHP 430 440 450 460 470 480 KKEVHLGACG ALKNISFGRD QDNKIAIKNC DGVPALVRLL RKARDMDLTE VITGTLWNLS 490 500 510 520 530 540 SHDSIKMEIV DHALHALTDE VIIPHSGWER EPNEDCKPRH IEWESVLTNT AGCLRNVSSE 550 560 570 580 590 600 RSEARRKLRE CDGLVDALIF IVQAEIGQKD SDSKLVENCV CLLRNLSYQV HREIPQAERY 610 620 630 640 650 660 QEAAPNVANN TGPHAASCFG AKKGKDEWFS RGKKPIEDPA NDTVDFPKRT SPARGYELLF 670 680 690 700 710 720 QPEVVRIYIS LLKESKTPAI LEASAGAIQN LCAGRWTYGR YIRSALRQEK ALSAIADLLT 730 740 750 760 770 780 NEHERVVKAA SGALRNLAVD ARNKELIGKH AIPNLVKNLP GGQQNSSWNF SEDTVISILN 790 800 810 820 830 840 TINEVIAENL EAAKKLRETQ GIEKLVLINK SGNRSEKEVR AAALVLQTIW GYKELRKPLE 850 860 870 880 890 900 KEGWKKSDFQ VNLNNASRSQ SSHSYDDSTL PLIDRNQKSD DNNYSTPNER GDHNRTLDRS 910 GDLGDMEPLK GTTPLMQKI
	Isoform 1 [UniParc]. Checksum: 75E46E40901611AF	FASTA	913	101,880
	10 20 30 40 50 60 MDDSEVESTA SILASVKEQE AQFEKLTRAL EEERRHVSAQ LERVRVSPQD ANPLMANGTL 70 80 90 100 110 120 TRRHQNGRFV GDADLERQKF SDLKLNGPQD HSHLLYSTIP RMQEPGQIVE TYTEEDPEGA 130 140 150 160 170 180 MSVVSVETSD DGTTRRTETT VKKVVKTVTT RTVQPVAMGP DGLPVDASSV SNNYIQTLGR 190 200 210 220 230 240 DFRKNGNGGP GPYVGQAGTA TLPRNFHYPP DGYSRHYEDG YPGGSDNYGS LSRVTRIEER 250 260 270 280 290 300 YRPSMEGYRA PSRQDVYGPQ PQVRVGGSSV DLHRFHPEPY GLEDDQRSMG YDDLDYGMMS 310 320 330 340 350 360 DYGTARRTGT PSDPRRRLRS YEDMIGEEVP SDQYYWAPLA QHERGSLASL DSLRKGGPPP 370 380 390 400 410 420 PNWRQPELPE VIAMLGFRLD AVKSNAAAYL QHLCYRNDKV KTDVRKLKGI PVLVGLLDHP 430 440 450 460 470 480 KKEVHLGACG ALKNISFGRD QDNKIAIKNC DGVPALVRLL RKARDMDLTE VITGTLWNLS 490 500 510 520 530 540 SHDSIKMEIV DHALHALTDE VIIPHSGWER EPNEDCKPRH IEWESVLTNT AGCLRNVSSE 550 560 570 580 590 600 RSEARRKLRE CDGLVDALIF IVQAEIGQKD SDSKLVENCV CLLRNLSYQV HREIPQAERY 610 620 630 640 650 660 QEAAPNVANN TGPHAASCFG AKKGKGKKPI EDPANDTVDF PKRTSPARGY ELLFQPEVVR 670 680 690 700 710 720 IYISLLKESK TPAILEASAG AIQNLCAGRW TYGRYIRSAL RQEKALSAIA DLLTNEHERV 730 740 750 760 770 780 VKAASGALRN LAVDARNKEL IGKHAIPNLV KNLPGGQQNS SWNFSEDTVI SILNTINEVI 790 800 810 820 830 840 AENLEAAKKL RETQGIEKLV LINKSGNRSE KEVRAAALVL QTIWGYKELR KPLEKEGWKK 850 860 870 880 890 900 SDFQVNLNNA SRSQSSHSYD DSTLPLIDRN QKSDDNNYST PNERGDHNRT LDRSGDLGDM 910 EPLKGTTPLM QKI
	Isoform 2ABC [UniParc]. Checksum: 57A26859239AA55A	FASTA	914	102,063
	10 20 30 40 50 60 MANGTLTRRH QNGRFVGDAD LERQKFSDLK LNGPQDHSHL LYSTIPRMQE PGQIVETYTE 70 80 90 100 110 120 EDPEGAMSVV SVETSDDGTT RRTETTVKKV VKTVTTRTVQ PVAMGPDGLP VDASSVSNNY 130 140 150 160 170 180 IQTLGRDFRK NGNGGPGPYV GQAGTATLPR NFHYPPDGYS RHYEDGYPGG SDNYGSLSRV 190 200 210 220 230 240 TRIEERYRPS MEGYRAPSRQ DVYGPQPQVR VGGSSVDLHR FHPEPYGLED DQRSMGYDDL 250 260 270 280 290 300 DYGMMSDYGT ARRTGTPSDP RRRLRSYEDM IGEEVPSDQY YWAPLAQHER GSLASLDSLR 310 320 330 340 350 360 KGGPPPPNWR QPELPEVIAM LGFRLDAVKS NAAAYLQHLC YRNDKVKTDV RKLKGIPVLV 370 380 390 400 410 420 GLLDHPKKEV HLGACGALKN ISFGRDQDNK IAIKNCDGVP ALVRLLRKAR DMDLTEVITG 430 440 450 460 470 480 TLWNLSSHDS IKMEIVDHAL HALTDEVIIP HSGWEREPNE DCKPRHIEWE SVLTNTAGCL 490 500 510 520 530 540 RNVSSERSEA RRKLRECDGL VDALIFIVQA EIGQKDSDSK LVENCVCLLR NLSYQVHREI 550 560 570 580 590 600 PQAERYQEAA PNVANNTGPH AASCFGAKKG KDEWFSRGKK PIEDPANDTV DFPKRTSPAR 610 620 630 640 650 660 GYELLFQPEV VRIYISLLKE SKTPAILEAS AGAIQNLCAG RWTYGRYIRS ALRQEKALSA 670 680 690 700 710 720 IADLLTNEHE RVVKAASGAL RNLAVDARNK ELIGKHAIPN LVKNLPGGQQ NSSWNFSEDT 730 740 750 760 770 780 VISILNTINE VIAENLEAAK KLRETQGIEK LVLINKSGNR SEKEVRAAAL VLQTIWGYKE 790 800 810 820 830 840 LRKPLEKEGW KKSDFQVNLN NASRSQSSHS YDDSTLPLID RNQKSDKKPD REEIQMSNMG 850 860 870 880 890 900 SNTKSLDNNY STPNERGDHN RTLDRSGDLG DMEPLKGTTP LMQDEGQESL EEELDVLVLD 910 DEGGQVSYPS MQKI
	Isoform 2AB [UniParc]. Checksum: 95094A101A1B6DB4	FASTA	908	101,242
	10 20 30 40 50 60 MANGTLTRRH QNGRFVGDAD LERQKFSDLK LNGPQDHSHL LYSTIPRMQE PGQIVETYTE 70 80 90 100 110 120 EDPEGAMSVV SVETSDDGTT RRTETTVKKV VKTVTTRTVQ PVAMGPDGLP VDASSVSNNY 130 140 150 160 170 180 IQTLGRDFRK NGNGGPGPYV GQAGTATLPR NFHYPPDGYS RHYEDGYPGG SDNYGSLSRV 190 200 210 220 230 240 TRIEERYRPS MEGYRAPSRQ DVYGPQPQVR VGGSSVDLHR FHPEPYGLED DQRSMGYDDL 250 260 270 280 290 300 DYGMMSDYGT ARRTGTPSDP RRRLRSYEDM IGEEVPSDQY YWAPLAQHER GSLASLDSLR 310 320 330 340 350 360 KGGPPPPNWR QPELPEVIAM LGFRLDAVKS NAAAYLQHLC YRNDKVKTDV RKLKGIPVLV 370 380 390 400 410 420 GLLDHPKKEV HLGACGALKN ISFGRDQDNK IAIKNCDGVP ALVRLLRKAR DMDLTEVITG 430 440 450 460 470 480 TLWNLSSHDS IKMEIVDHAL HALTDEVIIP HSGWEREPNE DCKPRHIEWE SVLTNTAGCL 490 500 510 520 530 540 RNVSSERSEA RRKLRECDGL VDALIFIVQA EIGQKDSDSK LVENCVCLLR NLSYQVHREI 550 560 570 580 590 600 PQAERYQEAA PNVANNTGPH AASCFGAKKG KGKKPIEDPA NDTVDFPKRT SPARGYELLF 610 620 630 640 650 660 QPEVVRIYIS LLKESKTPAI LEASAGAIQN LCAGRWTYGR YIRSALRQEK ALSAIADLLT 670 680 690 700 710 720 NEHERVVKAA SGALRNLAVD ARNKELIGKH AIPNLVKNLP GGQQNSSWNF SEDTVISILN 730 740 750 760 770 780 TINEVIAENL EAAKKLRETQ GIEKLVLINK SGNRSEKEVR AAALVLQTIW GYKELRKPLE 790 800 810 820 830 840 KEGWKKSDFQ VNLNNASRSQ SSHSYDDSTL PLIDRNQKSD KKPDREEIQM SNMGSNTKSL 850 860 870 880 890 900 DNNYSTPNER GDHNRTLDRS GDLGDMEPLK GTTPLMQDEG QESLEEELDV LVLDDEGGQV SYPSMQKI
	Isoform 2AC [UniParc]. Checksum: DF4D8956D2827CAA	FASTA	885	98,870
	10 20 30 40 50 60 MANGTLTRRH QNGRFVGDAD LERQKFSDLK LNGPQDHSHL LYSTIPRMQE PGQIVETYTE 70 80 90 100 110 120 EDPEGAMSVV SVETSDDGTT RRTETTVKKV VKTVTTRTVQ PVAMGPDGLP VDASSVSNNY 130 140 150 160 170 180 IQTLGRDFRK NGNGGPGPYV GQAGTATLPR NFHYPPDGYS RHYEDGYPGG SDNYGSLSRV 190 200 210 220 230 240 TRIEERYRPS MEGYRAPSRQ DVYGPQPQVR VGGSSVDLHR FHPEPYGLED DQRSMGYDDL 250 260 270 280 290 300 DYGMMSDYGT ARRTGTPSDP RRRLRSYEDM IGEEVPSDQY YWAPLAQHER GSLASLDSLR 310 320 330 340 350 360 KGGPPPPNWR QPELPEVIAM LGFRLDAVKS NAAAYLQHLC YRNDKVKTDV RKLKGIPVLV 370 380 390 400 410 420 GLLDHPKKEV HLGACGALKN ISFGRDQDNK IAIKNCDGVP ALVRLLRKAR DMDLTEVITG 430 440 450 460 470 480 TLWNLSSHDS IKMEIVDHAL HALTDEVIIP HSGWEREPNE DCKPRHIEWE SVLTNTAGCL 490 500 510 520 530 540 RNVSSERSEA RRKLRECDGL VDALIFIVQA EIGQKDSDSK LVENCVCLLR NLSYQVHREI 550 560 570 580 590 600 PQAERYQEAA PNVANNTGPH AASCFGAKKG KDEWFSRGKK PIEDPANDTV DFPKRTSPAR 610 620 630 640 650 660 GYELLFQPEV VRIYISLLKE SKTPAILEAS AGAIQNLCAG RWTYGRYIRS ALRQEKALSA 670 680 690 700 710 720 IADLLTNEHE RVVKAASGAL RNLAVDARNK ELIGKHAIPN LVKNLPGGQQ NSSWNFSEDT 730 740 750 760 770 780 VISILNTINE VIAENLEAAK KLRETQGIEK LVLINKSGNR SEKEVRAAAL VLQTIWGYKE 790 800 810 820 830 840 LRKPLEKEGW KKSDFQVNLN NASRSQSSHS YDDSTLPLID RNQKSDKKPD REEIQMSNMG 850 860 870 880 SNTKSLDNNY STPNERGDHN RTLDRSGDLG DMEPLKGTTP LMQKI
	Isoform 2BC [UniParc]. Checksum: 0EDA126CDB512EC6	FASTA	894	99,788
	10 20 30 40 50 60 MANGTLTRRH QNGRFVGDAD LERQKFSDLK LNGPQDHSHL LYSTIPRMQE PGQIVETYTE 70 80 90 100 110 120 EDPEGAMSVV SVETSDDGTT RRTETTVKKV VKTVTTRTVQ PVAMGPDGLP VDASSVSNNY 130 140 150 160 170 180 IQTLGRDFRK NGNGGPGPYV GQAGTATLPR NFHYPPDGYS RHYEDGYPGG SDNYGSLSRV 190 200 210 220 230 240 TRIEERYRPS MEGYRAPSRQ DVYGPQPQVR VGGSSVDLHR FHPEPYGLED DQRSMGYDDL 250 260 270 280 290 300 DYGMMSDYGT ARRTGTPSDP RRRLRSYEDM IGEEVPSDQY YWAPLAQHER GSLASLDSLR 310 320 330 340 350 360 KGGPPPPNWR QPELPEVIAM LGFRLDAVKS NAAAYLQHLC YRNDKVKTDV RKLKGIPVLV 370 380 390 400 410 420 GLLDHPKKEV HLGACGALKN ISFGRDQDNK IAIKNCDGVP ALVRLLRKAR DMDLTEVITG 430 440 450 460 470 480 TLWNLSSHDS IKMEIVDHAL HALTDEVIIP HSGWEREPNE DCKPRHIEWE SVLTNTAGCL 490 500 510 520 530 540 RNVSSERSEA RRKLRECDGL VDALIFIVQA EIGQKDSDSK LVENCVCLLR NLSYQVHREI 550 560 570 580 590 600 PQAERYQEAA PNVANNTGPH AASCFGAKKG KDEWFSRGKK PIEDPANDTV DFPKRTSPAR 610 620 630 640 650 660 GYELLFQPEV VRIYISLLKE SKTPAILEAS AGAIQNLCAG RWTYGRYIRS ALRQEKALSA 670 680 690 700 710 720 IADLLTNEHE RVVKAASGAL RNLAVDARNK ELIGKHAIPN LVKNLPGGQQ NSSWNFSEDT 730 740 750 760 770 780 VISILNTINE VIAENLEAAK KLRETQGIEK LVLINKSGNR SEKEVRAAAL VLQTIWGYKE 790 800 810 820 830 840 LRKPLEKEGW KKSDFQVNLN NASRSQSSHS YDDSTLPLID RNQKSDDNNY STPNERGDHN 850 860 870 880 890 RTLDRSGDLG DMEPLKGTTP LMQDEGQESL EEELDVLVLD DEGGQVSYPS MQKI
	Isoform 2A [UniParc]. Checksum: F58CA78A7097EFEB	FASTA	879	98,049
	10 20 30 40 50 60 MANGTLTRRH QNGRFVGDAD LERQKFSDLK LNGPQDHSHL LYSTIPRMQE PGQIVETYTE 70 80 90 100 110 120 EDPEGAMSVV SVETSDDGTT RRTETTVKKV VKTVTTRTVQ PVAMGPDGLP VDASSVSNNY 130 140 150 160 170 180 IQTLGRDFRK NGNGGPGPYV GQAGTATLPR NFHYPPDGYS RHYEDGYPGG SDNYGSLSRV 190 200 210 220 230 240 TRIEERYRPS MEGYRAPSRQ DVYGPQPQVR VGGSSVDLHR FHPEPYGLED DQRSMGYDDL 250 260 270 280 290 300 DYGMMSDYGT ARRTGTPSDP RRRLRSYEDM IGEEVPSDQY YWAPLAQHER GSLASLDSLR 310 320 330 340 350 360 KGGPPPPNWR QPELPEVIAM LGFRLDAVKS NAAAYLQHLC YRNDKVKTDV RKLKGIPVLV 370 380 390 400 410 420 GLLDHPKKEV HLGACGALKN ISFGRDQDNK IAIKNCDGVP ALVRLLRKAR DMDLTEVITG 430 440 450 460 470 480 TLWNLSSHDS IKMEIVDHAL HALTDEVIIP HSGWEREPNE DCKPRHIEWE SVLTNTAGCL 490 500 510 520 530 540 RNVSSERSEA RRKLRECDGL VDALIFIVQA EIGQKDSDSK LVENCVCLLR NLSYQVHREI 550 560 570 580 590 600 PQAERYQEAA PNVANNTGPH AASCFGAKKG KGKKPIEDPA NDTVDFPKRT SPARGYELLF 610 620 630 640 650 660 QPEVVRIYIS LLKESKTPAI LEASAGAIQN LCAGRWTYGR YIRSALRQEK ALSAIADLLT 670 680 690 700 710 720 NEHERVVKAA SGALRNLAVD ARNKELIGKH AIPNLVKNLP GGQQNSSWNF SEDTVISILN 730 740 750 760 770 780 TINEVIAENL EAAKKLRETQ GIEKLVLINK SGNRSEKEVR AAALVLQTIW GYKELRKPLE 790 800 810 820 830 840 KEGWKKSDFQ VNLNNASRSQ SSHSYDDSTL PLIDRNQKSD KKPDREEIQM SNMGSNTKSL 850 860 870 DNNYSTPNER GDHNRTLDRS GDLGDMEPLK GTTPLMQKI
	Isoform 2B [UniParc]. Checksum: F1E747E25FFC5277	FASTA	888	98,967
	10 20 30 40 50 60 MANGTLTRRH QNGRFVGDAD LERQKFSDLK LNGPQDHSHL LYSTIPRMQE PGQIVETYTE 70 80 90 100 110 120 EDPEGAMSVV SVETSDDGTT RRTETTVKKV VKTVTTRTVQ PVAMGPDGLP VDASSVSNNY 130 140 150 160 170 180 IQTLGRDFRK NGNGGPGPYV GQAGTATLPR NFHYPPDGYS RHYEDGYPGG SDNYGSLSRV 190 200 210 220 230 240 TRIEERYRPS MEGYRAPSRQ DVYGPQPQVR VGGSSVDLHR FHPEPYGLED DQRSMGYDDL 250 260 270 280 290 300 DYGMMSDYGT ARRTGTPSDP RRRLRSYEDM IGEEVPSDQY YWAPLAQHER GSLASLDSLR 310 320 330 340 350 360 KGGPPPPNWR QPELPEVIAM LGFRLDAVKS NAAAYLQHLC YRNDKVKTDV RKLKGIPVLV 370 380 390 400 410 420 GLLDHPKKEV HLGACGALKN ISFGRDQDNK IAIKNCDGVP ALVRLLRKAR DMDLTEVITG 430 440 450 460 470 480 TLWNLSSHDS IKMEIVDHAL HALTDEVIIP HSGWEREPNE DCKPRHIEWE SVLTNTAGCL 490 500 510 520 530 540 RNVSSERSEA RRKLRECDGL VDALIFIVQA EIGQKDSDSK LVENCVCLLR NLSYQVHREI 550 560 570 580 590 600 PQAERYQEAA PNVANNTGPH AASCFGAKKG KGKKPIEDPA NDTVDFPKRT SPARGYELLF 610 620 630 640 650 660 QPEVVRIYIS LLKESKTPAI LEASAGAIQN LCAGRWTYGR YIRSALRQEK ALSAIADLLT 670 680 690 700 710 720 NEHERVVKAA SGALRNLAVD ARNKELIGKH AIPNLVKNLP GGQQNSSWNF SEDTVISILN 730 740 750 760 770 780 TINEVIAENL EAAKKLRETQ GIEKLVLINK SGNRSEKEVR AAALVLQTIW GYKELRKPLE 790 800 810 820 830 840 KEGWKKSDFQ VNLNNASRSQ SSHSYDDSTL PLIDRNQKSD DNNYSTPNER GDHNRTLDRS 850 860 870 880 GDLGDMEPLK GTTPLMQDEG QESLEEELDV LVLDDEGGQV SYPSMQKI
	Isoform 2C [UniParc]. Checksum: AF57E6063E68C0D4	FASTA	865	96,594
	10 20 30 40 50 60 MANGTLTRRH QNGRFVGDAD LERQKFSDLK LNGPQDHSHL LYSTIPRMQE PGQIVETYTE 70 80 90 100 110 120 EDPEGAMSVV SVETSDDGTT RRTETTVKKV VKTVTTRTVQ PVAMGPDGLP VDASSVSNNY 130 140 150 160 170 180 IQTLGRDFRK NGNGGPGPYV GQAGTATLPR NFHYPPDGYS RHYEDGYPGG SDNYGSLSRV 190 200 210 220 230 240 TRIEERYRPS MEGYRAPSRQ DVYGPQPQVR VGGSSVDLHR FHPEPYGLED DQRSMGYDDL 250 260 270 280 290 300 DYGMMSDYGT ARRTGTPSDP RRRLRSYEDM IGEEVPSDQY YWAPLAQHER GSLASLDSLR 310 320 330 340 350 360 KGGPPPPNWR QPELPEVIAM LGFRLDAVKS NAAAYLQHLC YRNDKVKTDV RKLKGIPVLV 370 380 390 400 410 420 GLLDHPKKEV HLGACGALKN ISFGRDQDNK IAIKNCDGVP ALVRLLRKAR DMDLTEVITG 430 440 450 460 470 480 TLWNLSSHDS IKMEIVDHAL HALTDEVIIP HSGWEREPNE DCKPRHIEWE SVLTNTAGCL 490 500 510 520 530 540 RNVSSERSEA RRKLRECDGL VDALIFIVQA EIGQKDSDSK LVENCVCLLR NLSYQVHREI 550 560 570 580 590 600 PQAERYQEAA PNVANNTGPH AASCFGAKKG KDEWFSRGKK PIEDPANDTV DFPKRTSPAR 610 620 630 640 650 660 GYELLFQPEV VRIYISLLKE SKTPAILEAS AGAIQNLCAG RWTYGRYIRS ALRQEKALSA 670 680 690 700 710 720 IADLLTNEHE RVVKAASGAL RNLAVDARNK ELIGKHAIPN LVKNLPGGQQ NSSWNFSEDT 730 740 750 760 770 780 VISILNTINE VIAENLEAAK KLRETQGIEK LVLINKSGNR SEKEVRAAAL VLQTIWGYKE 790 800 810 820 830 840 LRKPLEKEGW KKSDFQVNLN NASRSQSSHS YDDSTLPLID RNQKSDDNNY STPNERGDHN 850 860 RTLDRSGDLG DMEPLKGTTP LMQKI
	Isoform 2 [UniParc]. Checksum: 42729AF49AA9B192	FASTA	859	95,774
	10 20 30 40 50 60 MANGTLTRRH QNGRFVGDAD LERQKFSDLK LNGPQDHSHL LYSTIPRMQE PGQIVETYTE 70 80 90 100 110 120 EDPEGAMSVV SVETSDDGTT RRTETTVKKV VKTVTTRTVQ PVAMGPDGLP VDASSVSNNY 130 140 150 160 170 180 IQTLGRDFRK NGNGGPGPYV GQAGTATLPR NFHYPPDGYS RHYEDGYPGG SDNYGSLSRV 190 200 210 220 230 240 TRIEERYRPS MEGYRAPSRQ DVYGPQPQVR VGGSSVDLHR FHPEPYGLED DQRSMGYDDL 250 260 270 280 290 300 DYGMMSDYGT ARRTGTPSDP RRRLRSYEDM IGEEVPSDQY YWAPLAQHER GSLASLDSLR 310 320 330 340 350 360 KGGPPPPNWR QPELPEVIAM LGFRLDAVKS NAAAYLQHLC YRNDKVKTDV RKLKGIPVLV 370 380 390 400 410 420 GLLDHPKKEV HLGACGALKN ISFGRDQDNK IAIKNCDGVP ALVRLLRKAR DMDLTEVITG 430 440 450 460 470 480 TLWNLSSHDS IKMEIVDHAL HALTDEVIIP HSGWEREPNE DCKPRHIEWE SVLTNTAGCL 490 500 510 520 530 540 RNVSSERSEA RRKLRECDGL VDALIFIVQA EIGQKDSDSK LVENCVCLLR NLSYQVHREI 550 560 570 580 590 600 PQAERYQEAA PNVANNTGPH AASCFGAKKG KGKKPIEDPA NDTVDFPKRT SPARGYELLF 610 620 630 640 650 660 QPEVVRIYIS LLKESKTPAI LEASAGAIQN LCAGRWTYGR YIRSALRQEK ALSAIADLLT 670 680 690 700 710 720 NEHERVVKAA SGALRNLAVD ARNKELIGKH AIPNLVKNLP GGQQNSSWNF SEDTVISILN 730 740 750 760 770 780 TINEVIAENL EAAKKLRETQ GIEKLVLINK SGNRSEKEVR AAALVLQTIW GYKELRKPLE 790 800 810 820 830 840 KEGWKKSDFQ VNLNNASRSQ SSHSYDDSTL PLIDRNQKSD DNNYSTPNER GDHNRTLDRS 850 GDLGDMEPLK GTTPLMQKI
	Isoform 3ABC [UniParc]. Checksum: 5F9E3A466CA81D74	FASTA	867	96,689
	10 20 30 40 50 60 MQEPGQIVET YTEEDPEGAM SVVSVETSDD GTTRRTETTV KKVVKTVTTR TVQPVAMGPD 70 80 90 100 110 120 GLPVDASSVS NNYIQTLGRD FRKNGNGGPG PYVGQAGTAT LPRNFHYPPD GYSRHYEDGY 130 140 150 160 170 180 PGGSDNYGSL SRVTRIEERY RPSMEGYRAP SRQDVYGPQP QVRVGGSSVD LHRFHPEPYG 190 200 210 220 230 240 LEDDQRSMGY DDLDYGMMSD YGTARRTGTP SDPRRRLRSY EDMIGEEVPS DQYYWAPLAQ 250 260 270 280 290 300 HERGSLASLD SLRKGGPPPP NWRQPELPEV IAMLGFRLDA VKSNAAAYLQ HLCYRNDKVK 310 320 330 340 350 360 TDVRKLKGIP VLVGLLDHPK KEVHLGACGA LKNISFGRDQ DNKIAIKNCD GVPALVRLLR 370 380 390 400 410 420 KARDMDLTEV ITGTLWNLSS HDSIKMEIVD HALHALTDEV IIPHSGWERE PNEDCKPRHI 430 440 450 460 470 480 EWESVLTNTA GCLRNVSSER SEARRKLREC DGLVDALIFI VQAEIGQKDS DSKLVENCVC 490 500 510 520 530 540 LLRNLSYQVH REIPQAERYQ EAAPNVANNT GPHAASCFGA KKGKDEWFSR GKKPIEDPAN 550 560 570 580 590 600 DTVDFPKRTS PARGYELLFQ PEVVRIYISL LKESKTPAIL EASAGAIQNL CAGRWTYGRY 610 620 630 640 650 660 IRSALRQEKA LSAIADLLTN EHERVVKAAS GALRNLAVDA RNKELIGKHA IPNLVKNLPG 670 680 690 700 710 720 GQQNSSWNFS EDTVISILNT INEVIAENLE AAKKLRETQG IEKLVLINKS GNRSEKEVRA 730 740 750 760 770 780 AALVLQTIWG YKELRKPLEK EGWKKSDFQV NLNNASRSQS SHSYDDSTLP LIDRNQKSDK 790 800 810 820 830 840 KPDREEIQMS NMGSNTKSLD NNYSTPNERG DHNRTLDRSG DLGDMEPLKG TTPLMQDEGQ 850 860 ESLEEELDVL VLDDEGGQVS YPSMQKI
	Isoform 3AB [UniParc]. Checksum: 3D2744052161BD93	FASTA	861	95,868
	10 20 30 40 50 60 MQEPGQIVET YTEEDPEGAM SVVSVETSDD GTTRRTETTV KKVVKTVTTR TVQPVAMGPD 70 80 90 100 110 120 GLPVDASSVS NNYIQTLGRD FRKNGNGGPG PYVGQAGTAT LPRNFHYPPD GYSRHYEDGY 130 140 150 160 170 180 PGGSDNYGSL SRVTRIEERY RPSMEGYRAP SRQDVYGPQP QVRVGGSSVD LHRFHPEPYG 190 200 210 220 230 240 LEDDQRSMGY DDLDYGMMSD YGTARRTGTP SDPRRRLRSY EDMIGEEVPS DQYYWAPLAQ 250 260 270 280 290 300 HERGSLASLD SLRKGGPPPP NWRQPELPEV IAMLGFRLDA VKSNAAAYLQ HLCYRNDKVK 310 320 330 340 350 360 TDVRKLKGIP VLVGLLDHPK KEVHLGACGA LKNISFGRDQ DNKIAIKNCD GVPALVRLLR 370 380 390 400 410 420 KARDMDLTEV ITGTLWNLSS HDSIKMEIVD HALHALTDEV IIPHSGWERE PNEDCKPRHI 430 440 450 460 470 480 EWESVLTNTA GCLRNVSSER SEARRKLREC DGLVDALIFI VQAEIGQKDS DSKLVENCVC 490 500 510 520 530 540 LLRNLSYQVH REIPQAERYQ EAAPNVANNT GPHAASCFGA KKGKGKKPIE DPANDTVDFP 550 560 570 580 590 600 KRTSPARGYE LLFQPEVVRI YISLLKESKT PAILEASAGA IQNLCAGRWT YGRYIRSALR 610 620 630 640 650 660 QEKALSAIAD LLTNEHERVV KAASGALRNL AVDARNKELI GKHAIPNLVK NLPGGQQNSS 670 680 690 700 710 720 WNFSEDTVIS ILNTINEVIA ENLEAAKKLR ETQGIEKLVL INKSGNRSEK EVRAAALVLQ 730 740 750 760 770 780 TIWGYKELRK PLEKEGWKKS DFQVNLNNAS RSQSSHSYDD STLPLIDRNQ KSDKKPDREE 790 800 810 820 830 840 IQMSNMGSNT KSLDNNYSTP NERGDHNRTL DRSGDLGDME PLKGTTPLMQ DEGQESLEEE 850 860 LDVLVLDDEG GQVSYPSMQK I
	Isoform 3AC [UniParc]. Checksum: F840912548316394	FASTA	838	93,496
	10 20 30 40 50 60 MQEPGQIVET YTEEDPEGAM SVVSVETSDD GTTRRTETTV KKVVKTVTTR TVQPVAMGPD 70 80 90 100 110 120 GLPVDASSVS NNYIQTLGRD FRKNGNGGPG PYVGQAGTAT LPRNFHYPPD GYSRHYEDGY 130 140 150 160 170 180 PGGSDNYGSL SRVTRIEERY RPSMEGYRAP SRQDVYGPQP QVRVGGSSVD LHRFHPEPYG 190 200 210 220 230 240 LEDDQRSMGY DDLDYGMMSD YGTARRTGTP SDPRRRLRSY EDMIGEEVPS DQYYWAPLAQ 250 260 270 280 290 300 HERGSLASLD SLRKGGPPPP NWRQPELPEV IAMLGFRLDA VKSNAAAYLQ HLCYRNDKVK 310 320 330 340 350 360 TDVRKLKGIP VLVGLLDHPK KEVHLGACGA LKNISFGRDQ DNKIAIKNCD GVPALVRLLR 370 380 390 400 410 420 KARDMDLTEV ITGTLWNLSS HDSIKMEIVD HALHALTDEV IIPHSGWERE PNEDCKPRHI 430 440 450 460 470 480 EWESVLTNTA GCLRNVSSER SEARRKLREC DGLVDALIFI VQAEIGQKDS DSKLVENCVC 490 500 510 520 530 540 LLRNLSYQVH REIPQAERYQ EAAPNVANNT GPHAASCFGA KKGKDEWFSR GKKPIEDPAN 550 560 570 580 590 600 DTVDFPKRTS PARGYELLFQ PEVVRIYISL LKESKTPAIL EASAGAIQNL CAGRWTYGRY 610 620 630 640 650 660 IRSALRQEKA LSAIADLLTN EHERVVKAAS GALRNLAVDA RNKELIGKHA IPNLVKNLPG 670 680 690 700 710 720 GQQNSSWNFS EDTVISILNT INEVIAENLE AAKKLRETQG IEKLVLINKS GNRSEKEVRA 730 740 750 760 770 780 AALVLQTIWG YKELRKPLEK EGWKKSDFQV NLNNASRSQS SHSYDDSTLP LIDRNQKSDK 790 800 810 820 830 KPDREEIQMS NMGSNTKSLD NNYSTPNERG DHNRTLDRSG DLGDMEPLKG TTPLMQKI
	Isoform 3BC [UniParc]. Checksum: FCAE088A184C3904	FASTA	847	94,414
	10 20 30 40 50 60 MQEPGQIVET YTEEDPEGAM SVVSVETSDD GTTRRTETTV KKVVKTVTTR TVQPVAMGPD 70 80 90 100 110 120 GLPVDASSVS NNYIQTLGRD FRKNGNGGPG PYVGQAGTAT LPRNFHYPPD GYSRHYEDGY 130 140 150 160 170 180 PGGSDNYGSL SRVTRIEERY RPSMEGYRAP SRQDVYGPQP QVRVGGSSVD LHRFHPEPYG 190 200 210 220 230 240 LEDDQRSMGY DDLDYGMMSD YGTARRTGTP SDPRRRLRSY EDMIGEEVPS DQYYWAPLAQ 250 260 270 280 290 300 HERGSLASLD SLRKGGPPPP NWRQPELPEV IAMLGFRLDA VKSNAAAYLQ HLCYRNDKVK 310 320 330 340 350 360 TDVRKLKGIP VLVGLLDHPK KEVHLGACGA LKNISFGRDQ DNKIAIKNCD GVPALVRLLR 370 380 390 400 410 420 KARDMDLTEV ITGTLWNLSS HDSIKMEIVD HALHALTDEV IIPHSGWERE PNEDCKPRHI 430 440 450 460 470 480 EWESVLTNTA GCLRNVSSER SEARRKLREC DGLVDALIFI VQAEIGQKDS DSKLVENCVC 490 500 510 520 530 540 LLRNLSYQVH REIPQAERYQ EAAPNVANNT GPHAASCFGA KKGKDEWFSR GKKPIEDPAN 550 560 570 580 590 600 DTVDFPKRTS PARGYELLFQ PEVVRIYISL LKESKTPAIL EASAGAIQNL CAGRWTYGRY 610 620 630 640 650 660 IRSALRQEKA LSAIADLLTN EHERVVKAAS GALRNLAVDA RNKELIGKHA IPNLVKNLPG 670 680 690 700 710 720 GQQNSSWNFS EDTVISILNT INEVIAENLE AAKKLRETQG IEKLVLINKS GNRSEKEVRA 730 740 750 760 770 780 AALVLQTIWG YKELRKPLEK EGWKKSDFQV NLNNASRSQS SHSYDDSTLP LIDRNQKSDD 790 800 810 820 830 840 NNYSTPNERG DHNRTLDRSG DLGDMEPLKG TTPLMQDEGQ ESLEEELDVL VLDDEGGQVS YPSMQKI
	Isoform 3A [UniParc]. Checksum: FAB29A345A6AABBC	FASTA	832	92,675
	10 20 30 40 50 60 MQEPGQIVET YTEEDPEGAM SVVSVETSDD GTTRRTETTV KKVVKTVTTR TVQPVAMGPD 70 80 90 100 110 120 GLPVDASSVS NNYIQTLGRD FRKNGNGGPG PYVGQAGTAT LPRNFHYPPD GYSRHYEDGY 130 140 150 160 170 180 PGGSDNYGSL SRVTRIEERY RPSMEGYRAP SRQDVYGPQP QVRVGGSSVD LHRFHPEPYG 190 200 210 220 230 240 LEDDQRSMGY DDLDYGMMSD YGTARRTGTP SDPRRRLRSY EDMIGEEVPS DQYYWAPLAQ 250 260 270 280 290 300 HERGSLASLD SLRKGGPPPP NWRQPELPEV IAMLGFRLDA VKSNAAAYLQ HLCYRNDKVK 310 320 330 340 350 360 TDVRKLKGIP VLVGLLDHPK KEVHLGACGA LKNISFGRDQ DNKIAIKNCD GVPALVRLLR 370 380 390 400 410 420 KARDMDLTEV ITGTLWNLSS HDSIKMEIVD HALHALTDEV IIPHSGWERE PNEDCKPRHI 430 440 450 460 470 480 EWESVLTNTA GCLRNVSSER SEARRKLREC DGLVDALIFI VQAEIGQKDS DSKLVENCVC 490 500 510 520 530 540 LLRNLSYQVH REIPQAERYQ EAAPNVANNT GPHAASCFGA KKGKGKKPIE DPANDTVDFP 550 560 570 580 590 600 KRTSPARGYE LLFQPEVVRI YISLLKESKT PAILEASAGA IQNLCAGRWT YGRYIRSALR 610 620 630 640 650 660 QEKALSAIAD LLTNEHERVV KAASGALRNL AVDARNKELI GKHAIPNLVK NLPGGQQNSS 670 680 690 700 710 720 WNFSEDTVIS ILNTINEVIA ENLEAAKKLR ETQGIEKLVL INKSGNRSEK EVRAAALVLQ 730 740 750 760 770 780 TIWGYKELRK PLEKEGWKKS DFQVNLNNAS RSQSSHSYDD STLPLIDRNQ KSDKKPDREE 790 800 810 820 830 IQMSNMGSNT KSLDNNYSTP NERGDHNRTL DRSGDLGDME PLKGTTPLMQ KI
	Isoform 3B [UniParc]. Checksum: 0625F2E552E421ED	FASTA	841	93,593
	10 20 30 40 50 60 MQEPGQIVET YTEEDPEGAM SVVSVETSDD GTTRRTETTV KKVVKTVTTR TVQPVAMGPD 70 80 90 100 110 120 GLPVDASSVS NNYIQTLGRD FRKNGNGGPG PYVGQAGTAT LPRNFHYPPD GYSRHYEDGY 130 140 150 160 170 180 PGGSDNYGSL SRVTRIEERY RPSMEGYRAP SRQDVYGPQP QVRVGGSSVD LHRFHPEPYG 190 200 210 220 230 240 LEDDQRSMGY DDLDYGMMSD YGTARRTGTP SDPRRRLRSY EDMIGEEVPS DQYYWAPLAQ 250 260 270 280 290 300 HERGSLASLD SLRKGGPPPP NWRQPELPEV IAMLGFRLDA VKSNAAAYLQ HLCYRNDKVK 310 320 330 340 350 360 TDVRKLKGIP VLVGLLDHPK KEVHLGACGA LKNISFGRDQ DNKIAIKNCD GVPALVRLLR 370 380 390 400 410 420 KARDMDLTEV ITGTLWNLSS HDSIKMEIVD HALHALTDEV IIPHSGWERE PNEDCKPRHI 430 440 450 460 470 480 EWESVLTNTA GCLRNVSSER SEARRKLREC DGLVDALIFI VQAEIGQKDS DSKLVENCVC 490 500 510 520 530 540 LLRNLSYQVH REIPQAERYQ EAAPNVANNT GPHAASCFGA KKGKGKKPIE DPANDTVDFP 550 560 570 580 590 600 KRTSPARGYE LLFQPEVVRI YISLLKESKT PAILEASAGA IQNLCAGRWT YGRYIRSALR 610 620 630 640 650 660 QEKALSAIAD LLTNEHERVV KAASGALRNL AVDARNKELI GKHAIPNLVK NLPGGQQNSS 670 680 690 700 710 720 WNFSEDTVIS ILNTINEVIA ENLEAAKKLR ETQGIEKLVL INKSGNRSEK EVRAAALVLQ 730 740 750 760 770 780 TIWGYKELRK PLEKEGWKKS DFQVNLNNAS RSQSSHSYDD STLPLIDRNQ KSDDNNYSTP 790 800 810 820 830 840 NERGDHNRTL DRSGDLGDME PLKGTTPLMQ DEGQESLEEE LDVLVLDDEG GQVSYPSMQK I
	Isoform 3C [UniParc]. Checksum: 00C0F6756857E1CB	FASTA	818	91,220
	10 20 30 40 50 60 MQEPGQIVET YTEEDPEGAM SVVSVETSDD GTTRRTETTV KKVVKTVTTR TVQPVAMGPD 70 80 90 100 110 120 GLPVDASSVS NNYIQTLGRD FRKNGNGGPG PYVGQAGTAT LPRNFHYPPD GYSRHYEDGY 130 140 150 160 170 180 PGGSDNYGSL SRVTRIEERY RPSMEGYRAP SRQDVYGPQP QVRVGGSSVD LHRFHPEPYG 190 200 210 220 230 240 LEDDQRSMGY DDLDYGMMSD YGTARRTGTP SDPRRRLRSY EDMIGEEVPS DQYYWAPLAQ 250 260 270 280 290 300 HERGSLASLD SLRKGGPPPP NWRQPELPEV IAMLGFRLDA VKSNAAAYLQ HLCYRNDKVK 310 320 330 340 350 360 TDVRKLKGIP VLVGLLDHPK KEVHLGACGA LKNISFGRDQ DNKIAIKNCD GVPALVRLLR 370 380 390 400 410 420 KARDMDLTEV ITGTLWNLSS HDSIKMEIVD HALHALTDEV IIPHSGWERE PNEDCKPRHI 430 440 450 460 470 480 EWESVLTNTA GCLRNVSSER SEARRKLREC DGLVDALIFI VQAEIGQKDS DSKLVENCVC 490 500 510 520 530 540 LLRNLSYQVH REIPQAERYQ EAAPNVANNT GPHAASCFGA KKGKDEWFSR GKKPIEDPAN 550 560 570 580 590 600 DTVDFPKRTS PARGYELLFQ PEVVRIYISL LKESKTPAIL EASAGAIQNL CAGRWTYGRY 610 620 630 640 650 660 IRSALRQEKA LSAIADLLTN EHERVVKAAS GALRNLAVDA RNKELIGKHA IPNLVKNLPG 670 680 690 700 710 720 GQQNSSWNFS EDTVISILNT INEVIAENLE AAKKLRETQG IEKLVLINKS GNRSEKEVRA 730 740 750 760 770 780 AALVLQTIWG YKELRKPLEK EGWKKSDFQV NLNNASRSQS SHSYDDSTLP LIDRNQKSDD 790 800 810 NNYSTPNERG DHNRTLDRSG DLGDMEPLKG TTPLMQKI
	Isoform 3 [UniParc]. Checksum: 236D4A0E2C25A95E	FASTA	812	90,400
	10 20 30 40 50 60 MQEPGQIVET YTEEDPEGAM SVVSVETSDD GTTRRTETTV KKVVKTVTTR TVQPVAMGPD 70 80 90 100 110 120 GLPVDASSVS NNYIQTLGRD FRKNGNGGPG PYVGQAGTAT LPRNFHYPPD GYSRHYEDGY 130 140 150 160 170 180 PGGSDNYGSL SRVTRIEERY RPSMEGYRAP SRQDVYGPQP QVRVGGSSVD LHRFHPEPYG 190 200 210 220 230 240 LEDDQRSMGY DDLDYGMMSD YGTARRTGTP SDPRRRLRSY EDMIGEEVPS DQYYWAPLAQ 250 260 270 280 290 300 HERGSLASLD SLRKGGPPPP NWRQPELPEV IAMLGFRLDA VKSNAAAYLQ HLCYRNDKVK 310 320 330 340 350 360 TDVRKLKGIP VLVGLLDHPK KEVHLGACGA LKNISFGRDQ DNKIAIKNCD GVPALVRLLR 370 380 390 400 410 420 KARDMDLTEV ITGTLWNLSS HDSIKMEIVD HALHALTDEV IIPHSGWERE PNEDCKPRHI 430 440 450 460 470 480 EWESVLTNTA GCLRNVSSER SEARRKLREC DGLVDALIFI VQAEIGQKDS DSKLVENCVC 490 500 510 520 530 540 LLRNLSYQVH REIPQAERYQ EAAPNVANNT GPHAASCFGA KKGKGKKPIE DPANDTVDFP 550 560 570 580 590 600 KRTSPARGYE LLFQPEVVRI YISLLKESKT PAILEASAGA IQNLCAGRWT YGRYIRSALR 610 620 630 640 650 660 QEKALSAIAD LLTNEHERVV KAASGALRNL AVDARNKELI GKHAIPNLVK NLPGGQQNSS 670 680 690 700 710 720 WNFSEDTVIS ILNTINEVIA ENLEAAKKLR ETQGIEKLVL INKSGNRSEK EVRAAALVLQ 730 740 750 760 770 780 TIWGYKELRK PLEKEGWKKS DFQVNLNNAS RSQSSHSYDD STLPLIDRNQ KSDDNNYSTP 790 800 810 NERGDHNRTL DRSGDLGDME PLKGTTPLMQ KI
	Isoform 4ABC [UniParc]. Checksum: DD32175D2F59D40D	FASTA	645	72,045
	10 20 30 40 50 60 MIGEEVPSDQ YYWAPLAQHE RGSLASLDSL RKGGPPPPNW RQPELPEVIA MLGFRLDAVK 70 80 90 100 110 120 SNAAAYLQHL CYRNDKVKTD VRKLKGIPVL VGLLDHPKKE VHLGACGALK NISFGRDQDN 130 140 150 160 170 180 KIAIKNCDGV PALVRLLRKA RDMDLTEVIT GTLWNLSSHD SIKMEIVDHA LHALTDEVII 190 200 210 220 230 240 PHSGWEREPN EDCKPRHIEW ESVLTNTAGC LRNVSSERSE ARRKLRECDG LVDALIFIVQ 250 260 270 280 290 300 AEIGQKDSDS KLVENCVCLL RNLSYQVHRE IPQAERYQEA APNVANNTGP HAASCFGAKK 310 320 330 340 350 360 GKDEWFSRGK KPIEDPANDT VDFPKRTSPA RGYELLFQPE VVRIYISLLK ESKTPAILEA 370 380 390 400 410 420 SAGAIQNLCA GRWTYGRYIR SALRQEKALS AIADLLTNEH ERVVKAASGA LRNLAVDARN 430 440 450 460 470 480 KELIGKHAIP NLVKNLPGGQ QNSSWNFSED TVISILNTIN EVIAENLEAA KKLRETQGIE 490 500 510 520 530 540 KLVLINKSGN RSEKEVRAAA LVLQTIWGYK ELRKPLEKEG WKKSDFQVNL NNASRSQSSH 550 560 570 580 590 600 SYDDSTLPLI DRNQKSDKKP DREEIQMSNM GSNTKSLDNN YSTPNERGDH NRTLDRSGDL 610 620 630 640 GDMEPLKGTT PLMQDEGQES LEEELDVLVL DDEGGQVSYP SMQKI
	Isoform 4AB [UniParc]. Checksum: F45EA4D758555CE3	FASTA	639	71,225
	10 20 30 40 50 60 MIGEEVPSDQ YYWAPLAQHE RGSLASLDSL RKGGPPPPNW RQPELPEVIA MLGFRLDAVK 70 80 90 100 110 120 SNAAAYLQHL CYRNDKVKTD VRKLKGIPVL VGLLDHPKKE VHLGACGALK NISFGRDQDN 130 140 150 160 170 180 KIAIKNCDGV PALVRLLRKA RDMDLTEVIT GTLWNLSSHD SIKMEIVDHA LHALTDEVII 190 200 210 220 230 240 PHSGWEREPN EDCKPRHIEW ESVLTNTAGC LRNVSSERSE ARRKLRECDG LVDALIFIVQ 250 260 270 280 290 300 AEIGQKDSDS KLVENCVCLL RNLSYQVHRE IPQAERYQEA APNVANNTGP HAASCFGAKK 310 320 330 340 350 360 GKGKKPIEDP ANDTVDFPKR TSPARGYELL FQPEVVRIYI SLLKESKTPA ILEASAGAIQ 370 380 390 400 410 420 NLCAGRWTYG RYIRSALRQE KALSAIADLL TNEHERVVKA ASGALRNLAV DARNKELIGK 430 440 450 460 470 480 HAIPNLVKNL PGGQQNSSWN FSEDTVISIL NTINEVIAEN LEAAKKLRET QGIEKLVLIN 490 500 510 520 530 540 KSGNRSEKEV RAAALVLQTI WGYKELRKPL EKEGWKKSDF QVNLNNASRS QSSHSYDDST 550 560 570 580 590 600 LPLIDRNQKS DKKPDREEIQ MSNMGSNTKS LDNNYSTPNE RGDHNRTLDR SGDLGDMEPL 610 620 630 KGTTPLMQDE GQESLEEELD VLVLDDEGGQ VSYPSMQKI
	Isoform 4AC [UniParc]. Checksum: E1014C183DAFB90D	FASTA	616	68,852
	10 20 30 40 50 60 MIGEEVPSDQ YYWAPLAQHE RGSLASLDSL RKGGPPPPNW RQPELPEVIA MLGFRLDAVK 70 80 90 100 110 120 SNAAAYLQHL CYRNDKVKTD VRKLKGIPVL VGLLDHPKKE VHLGACGALK NISFGRDQDN 130 140 150 160 170 180 KIAIKNCDGV PALVRLLRKA RDMDLTEVIT GTLWNLSSHD SIKMEIVDHA LHALTDEVII 190 200 210 220 230 240 PHSGWEREPN EDCKPRHIEW ESVLTNTAGC LRNVSSERSE ARRKLRECDG LVDALIFIVQ 250 260 270 280 290 300 AEIGQKDSDS KLVENCVCLL RNLSYQVHRE IPQAERYQEA APNVANNTGP HAASCFGAKK 310 320 330 340 350 360 GKDEWFSRGK KPIEDPANDT VDFPKRTSPA RGYELLFQPE VVRIYISLLK ESKTPAILEA 370 380 390 400 410 420 SAGAIQNLCA GRWTYGRYIR SALRQEKALS AIADLLTNEH ERVVKAASGA LRNLAVDARN 430 440 450 460 470 480 KELIGKHAIP NLVKNLPGGQ QNSSWNFSED TVISILNTIN EVIAENLEAA KKLRETQGIE 490 500 510 520 530 540 KLVLINKSGN RSEKEVRAAA LVLQTIWGYK ELRKPLEKEG WKKSDFQVNL NNASRSQSSH 550 560 570 580 590 600 SYDDSTLPLI DRNQKSDKKP DREEIQMSNM GSNTKSLDNN YSTPNERGDH NRTLDRSGDL 610 GDMEPLKGTT PLMQKI
	Isoform 4BC [UniParc]. Checksum: C304559FCFFA8285	FASTA	625	69,770
	10 20 30 40 50 60 MIGEEVPSDQ YYWAPLAQHE RGSLASLDSL RKGGPPPPNW RQPELPEVIA MLGFRLDAVK 70 80 90 100 110 120 SNAAAYLQHL CYRNDKVKTD VRKLKGIPVL VGLLDHPKKE VHLGACGALK NISFGRDQDN 130 140 150 160 170 180 KIAIKNCDGV PALVRLLRKA RDMDLTEVIT GTLWNLSSHD SIKMEIVDHA LHALTDEVII 190 200 210 220 230 240 PHSGWEREPN EDCKPRHIEW ESVLTNTAGC LRNVSSERSE ARRKLRECDG LVDALIFIVQ 250 260 270 280 290 300 AEIGQKDSDS KLVENCVCLL RNLSYQVHRE IPQAERYQEA APNVANNTGP HAASCFGAKK 310 320 330 340 350 360 GKDEWFSRGK KPIEDPANDT VDFPKRTSPA RGYELLFQPE VVRIYISLLK ESKTPAILEA 370 380 390 400 410 420 SAGAIQNLCA GRWTYGRYIR SALRQEKALS AIADLLTNEH ERVVKAASGA LRNLAVDARN 430 440 450 460 470 480 KELIGKHAIP NLVKNLPGGQ QNSSWNFSED TVISILNTIN EVIAENLEAA KKLRETQGIE 490 500 510 520 530 540 KLVLINKSGN RSEKEVRAAA LVLQTIWGYK ELRKPLEKEG WKKSDFQVNL NNASRSQSSH 550 560 570 580 590 600 SYDDSTLPLI DRNQKSDDNN YSTPNERGDH NRTLDRSGDL GDMEPLKGTT PLMQDEGQES 610 620 LEEELDVLVL DDEGGQVSYP SMQKI
	Isoform 4A [UniParc]. Checksum: 402B89CAE47E6A8E	FASTA	610	68,031
	10 20 30 40 50 60 MIGEEVPSDQ YYWAPLAQHE RGSLASLDSL RKGGPPPPNW RQPELPEVIA MLGFRLDAVK 70 80 90 100 110 120 SNAAAYLQHL CYRNDKVKTD VRKLKGIPVL VGLLDHPKKE VHLGACGALK NISFGRDQDN 130 140 150 160 170 180 KIAIKNCDGV PALVRLLRKA RDMDLTEVIT GTLWNLSSHD SIKMEIVDHA LHALTDEVII 190 200 210 220 230 240 PHSGWEREPN EDCKPRHIEW ESVLTNTAGC LRNVSSERSE ARRKLRECDG LVDALIFIVQ 250 260 270 280 290 300 AEIGQKDSDS KLVENCVCLL RNLSYQVHRE IPQAERYQEA APNVANNTGP HAASCFGAKK 310 320 330 340 350 360 GKGKKPIEDP ANDTVDFPKR TSPARGYELL FQPEVVRIYI SLLKESKTPA ILEASAGAIQ 370 380 390 400 410 420 NLCAGRWTYG RYIRSALRQE KALSAIADLL TNEHERVVKA ASGALRNLAV DARNKELIGK 430 440 450 460 470 480 HAIPNLVKNL PGGQQNSSWN FSEDTVISIL NTINEVIAEN LEAAKKLRET QGIEKLVLIN 490 500 510 520 530 540 KSGNRSEKEV RAAALVLQTI WGYKELRKPL EKEGWKKSDF QVNLNNASRS QSSHSYDDST 550 560 570 580 590 600 LPLIDRNQKS DKKPDREEIQ MSNMGSNTKS LDNNYSTPNE RGDHNRTLDR SGDLGDMEPL 610 KGTTPLMQKI
	Isoform 4B [UniParc]. Checksum: CDA4DDCC13391C98	FASTA	619	68,949
	10 20 30 40 50 60 MIGEEVPSDQ YYWAPLAQHE RGSLASLDSL RKGGPPPPNW RQPELPEVIA MLGFRLDAVK 70 80 90 100 110 120 SNAAAYLQHL CYRNDKVKTD VRKLKGIPVL VGLLDHPKKE VHLGACGALK NISFGRDQDN 130 140 150 160 170 180 KIAIKNCDGV PALVRLLRKA RDMDLTEVIT GTLWNLSSHD SIKMEIVDHA LHALTDEVII 190 200 210 220 230 240 PHSGWEREPN EDCKPRHIEW ESVLTNTAGC LRNVSSERSE ARRKLRECDG LVDALIFIVQ 250 260 270 280 290 300 AEIGQKDSDS KLVENCVCLL RNLSYQVHRE IPQAERYQEA APNVANNTGP HAASCFGAKK 310 320 330 340 350 360 GKGKKPIEDP ANDTVDFPKR TSPARGYELL FQPEVVRIYI SLLKESKTPA ILEASAGAIQ 370 380 390 400 410 420 NLCAGRWTYG RYIRSALRQE KALSAIADLL TNEHERVVKA ASGALRNLAV DARNKELIGK 430 440 450 460 470 480 HAIPNLVKNL PGGQQNSSWN FSEDTVISIL NTINEVIAEN LEAAKKLRET QGIEKLVLIN 490 500 510 520 530 540 KSGNRSEKEV RAAALVLQTI WGYKELRKPL EKEGWKKSDF QVNLNNASRS QSSHSYDDST 550 560 570 580 590 600 LPLIDRNQKS DDNNYSTPNE RGDHNRTLDR SGDLGDMEPL KGTTPLMQDE GQESLEEELD 610 VLVLDDEGGQ VSYPSMQKI
	Isoform 4C [UniParc]. Checksum: 4B8AC340FD304DC1	FASTA	596	66,577
	10 20 30 40 50 60 MIGEEVPSDQ YYWAPLAQHE RGSLASLDSL RKGGPPPPNW RQPELPEVIA MLGFRLDAVK 70 80 90 100 110 120 SNAAAYLQHL CYRNDKVKTD VRKLKGIPVL VGLLDHPKKE VHLGACGALK NISFGRDQDN 130 140 150 160 170 180 KIAIKNCDGV PALVRLLRKA RDMDLTEVIT GTLWNLSSHD SIKMEIVDHA LHALTDEVII 190 200 210 220 230 240 PHSGWEREPN EDCKPRHIEW ESVLTNTAGC LRNVSSERSE ARRKLRECDG LVDALIFIVQ 250 260 270 280 290 300 AEIGQKDSDS KLVENCVCLL RNLSYQVHRE IPQAERYQEA APNVANNTGP HAASCFGAKK 310 320 330 340 350 360 GKDEWFSRGK KPIEDPANDT VDFPKRTSPA RGYELLFQPE VVRIYISLLK ESKTPAILEA 370 380 390 400 410 420 SAGAIQNLCA GRWTYGRYIR SALRQEKALS AIADLLTNEH ERVVKAASGA LRNLAVDARN 430 440 450 460 470 480 KELIGKHAIP NLVKNLPGGQ QNSSWNFSED TVISILNTIN EVIAENLEAA KKLRETQGIE 490 500 510 520 530 540 KLVLINKSGN RSEKEVRAAA LVLQTIWGYK ELRKPLEKEG WKKSDFQVNL NNASRSQSSH 550 560 570 580 590 SYDDSTLPLI DRNQKSDDNN YSTPNERGDH NRTLDRSGDL GDMEPLKGTT PLMQKI
	Isoform 4 [UniParc]. Checksum: 4F6737C4A4E4972A	FASTA	590	65,756
	10 20 30 40 50 60 MIGEEVPSDQ YYWAPLAQHE RGSLASLDSL RKGGPPPPNW RQPELPEVIA MLGFRLDAVK 70 80 90 100 110 120 SNAAAYLQHL CYRNDKVKTD VRKLKGIPVL VGLLDHPKKE VHLGACGALK NISFGRDQDN 130 140 150 160 170 180 KIAIKNCDGV PALVRLLRKA RDMDLTEVIT GTLWNLSSHD SIKMEIVDHA LHALTDEVII 190 200 210 220 230 240 PHSGWEREPN EDCKPRHIEW ESVLTNTAGC LRNVSSERSE ARRKLRECDG LVDALIFIVQ 250 260 270 280 290 300 AEIGQKDSDS KLVENCVCLL RNLSYQVHRE IPQAERYQEA APNVANNTGP HAASCFGAKK 310 320 330 340 350 360 GKGKKPIEDP ANDTVDFPKR TSPARGYELL FQPEVVRIYI SLLKESKTPA ILEASAGAIQ 370 380 390 400 410 420 NLCAGRWTYG RYIRSALRQE KALSAIADLL TNEHERVVKA ASGALRNLAV DARNKELIGK 430 440 450 460 470 480 HAIPNLVKNL PGGQQNSSWN FSEDTVISIL NTINEVIAEN LEAAKKLRET QGIEKLVLIN 490 500 510 520 530 540 KSGNRSEKEV RAAALVLQTI WGYKELRKPL EKEGWKKSDF QVNLNNASRS QSSHSYDDST 550 560 570 580 590 LPLIDRNQKS DDNNYSTPNE RGDHNRTLDR SGDLGDMEPL KGTTPLMQKI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms." Keirsebilck A., Bonne S., Staes K., van Hengel J., Nollet F., Reynolds A., van Roy F. Genomics 50:129-146(1998) [PubMed: 9653641] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING. Tissue: Fetal kidney.
[2]	"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed: 9205841] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1AC). Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1AC). Tissue: Testis.
[4]	NIEHS SNPs program Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS CYS-217; CYS-464 AND LYS-915.
[5]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1A). Tissue: Testis.
[7]	"The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors." Kim L., Wong T.W. Mol. Cell. Biol. 15:4553-4561(1995) [PubMed: 7623846] [Abstract] Cited for: PHOSPHORYLATION BY FER, INTERACTION WITH FER.
[8]	"The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor." Daniel J.M., Reynolds A.B. Mol. Cell. Biol. 19:3614-3623(1999) [PubMed: 10207085] [Abstract] Cited for: INTERACTION WITH ZBTB33.
[9]	"The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)." Holsinger L.J., Ward K., Duffield B., Zachwieja J., Jallal B. Oncogene 21:7067-7076(2002) [PubMed: 12370829] [Abstract] Cited for: PHOSPHORYLATION, DEPHOSPHORYLATION BY PTPRJ.
[10]	"Laminar shear stress differentially modulates gene expression of p120 catenin, Kaiso transcription factor, and vascular endothelial cadherin in human coronary artery endothelial cells." Kondapalli J., Flozak A.S., Albuquerque M.L.C. J. Biol. Chem. 279:11417-11424(2004) [PubMed: 14699141] [Abstract] Cited for: TISSUE SPECIFICITY, INDUCTION.
[11]	"Global phosphoproteome of HT-29 human colon adenocarcinoma cells." Kim J.-E., Tannenbaum S.R., White F.M. J. Proteome Res. 4:1339-1346(2005) [PubMed: 16083285] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-349 AND SER-352, MASS SPECTROMETRY. Tissue: Colon adenocarcinoma.
[12]	"Phosphoproteome analysis of HeLa cells using stable isotope labeling with amino acids in cell culture (SILAC)." Amanchy R., Kalume D.E., Iwahori A., Zhong J., Pandey A. J. Proteome Res. 4:1661-1671(2005) [PubMed: 16212419] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-96; TYR-174; TYR-217; TYR-228; TYR-257; TYR-302 AND TYR-865, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules." Zhang Y., Wolf-Yadlin A., Ross P.L., Pappin D.J., Rush J., Lauffenburger D.A., White F.M. Mol. Cell. Proteomics 4:1240-1250(2005) [PubMed: 15951569] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-321 AND TYR-334, MASS SPECTROMETRY. Tissue: Mammary epithelium.
[14]	"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-217; TYR-228; TYR-257 AND TYR-280, MASS SPECTROMETRY.
[15]	"E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion." Strumane K., Bonnomet A., Stove C., Vandenbroucke R., Nawrocki-Raby B., Bruyneel E., Mareel M., Birembaut P., Berx G., van Roy F. Cancer Res. 66:10007-10015(2006) [PubMed: 17047063] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH NANOS1.
[16]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-47; TYR-228; SER-268; SER-269; THR-310; TYR-321; SER-349; SER-352 AND THR-916, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[17]	"The armadillo protein p0071 regulates Rho signalling during cytokinesis." Wolf A., Keil R., Gotzl O., Mun A., Schwarze K., Lederer M., Huttelmaier S., Hatzfeld M. Nat. Cell Biol. 8:1432-1440(2006) [PubMed: 17115030] [Abstract] Cited for: SUBCELLULAR LOCATION.
[18]	"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. , Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J. Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-96; TYR-257 AND TYR-904, MASS SPECTROMETRY. Tissue: Lung carcinoma.
[19]	"The transcriptional repressor Glis2 is a novel binding partner for p120 catenin." Hosking C.R., Ulloa F., Hogan C., Ferber E.C., Figueroa A., Gevaert K., Birchmeier W., Briscoe J., Fujita Y. Mol. Biol. Cell 18:1918-1927(2007) [PubMed: 17344476] [Abstract] Cited for: INTERACTION WITH GLIS2, FUNCTION.
[20]	"Specific phosphorylation of p120-catenin regulatory domain differently modulates its binding to RhoA." Castano J., Solanas G., Casagolda D., Raurell I., Villagrasa P., Bustelo X.R., Garcia de Herreros A., Dunach M. Mol. Cell. Biol. 27:1745-1757(2007) [PubMed: 17194753] [Abstract] Cited for: PHOSPHORYLATION AT TYR-112 BY FYN.
[21]	"Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks." Wolf-Yadlin A., Hautaniemi S., Lauffenburger D.A., White F.M. Proc. Natl. Acad. Sci. U.S.A. 104:5860-5865(2007) [PubMed: 17389395] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-174; TYR-208; TYR-213; TYR-217; TYR-228; TYR-257 AND TYR-280, MASS SPECTROMETRY. Tissue: Mammary epithelium.
[22]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-228; SER-230; SER-232; SER-244; SER-288 AND THR-869, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[23]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-47; SER-230 AND SER-288, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[24]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268; SER-269; SER-349 AND SER-352, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[25]	"An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells." Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A., Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D., Wiley H.S., Qian W.-J. J. Proteome Res. 8:3852-3861(2009) [PubMed: 19534553] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-96; TYR-174; TYR-193; TYR-213; TYR-228; TYR-248; TYR-257; TYR-280 AND TYR-904, MASS SPECTROMETRY. Tissue: Mammary epithelium.
[26]	"p120-catenin is a binding partner and substrate for Group B Pak kinases." Wong L.E., Reynolds A.B., Dissanayaka N.T., Minden A. J. Cell. Biochem. 110:1244-1254(2010) [PubMed: 20564219] [Abstract] Cited for: PHOSPHORYLATION AT SER-288 BY PAK7/PAK5.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF062319 mRNA. Translation: AAC39804.1.
AF062323 mRNA. Translation: AAC39808.1.
AF062341 mRNA. Translation: AAC39826.1.
AF062342 mRNA. Translation: AAC39827.1.
AF062322 mRNA. Translation: AAC39807.1.
AF062326 mRNA. Translation: AAC39811.1.
AF062328 mRNA. Translation: AAC39813.1.
AF062338 mRNA. Translation: AAC39823.1.
AF062324 mRNA. Translation: AAC39809.1.
AF062327 mRNA. Translation: AAC39812.1.
AF062329 mRNA. Translation: AAC39814.1.
AF062330 mRNA. Translation: AAC39815.1.
AF062331 mRNA. Translation: AAC39816.1.
AF062333 mRNA. Translation: AAC39818.1.
AF062334 mRNA. Translation: AAC39819.1.
AF062335 mRNA. Translation: AAC39820.1.
AF062336 mRNA. Translation: AAC39821.1.
AF062339 mRNA. Translation: AAC39824.1.
AF062340 mRNA. Translation: AAC39825.1.
AF062343 mRNA. Translation: AAC39828.1.
AF062317 mRNA. Translation: AAC39802.1.
AF062325 mRNA. Translation: AAC39810.1.
AF062332 mRNA. Translation: AAC39817.1.
AF062344 mRNA. Translation: AAC39829.1.
AF062321 mRNA. Translation: AAC39806.1.
AF062320 mRNA. Translation: AAC39805.1.
AF062337 mRNA. Translation: AAC39822.1.
AF062318 mRNA. Translation: AAC39803.1.
AB002382 mRNA. Translation: BAA20838.2. Different initiation.
AK292554 mRNA. Translation: BAF85243.1.
AY505564 Genomic DNA. Translation: AAR84236.1.
AP001931 Genomic DNA. No translation available.
BC075795 mRNA. Translation: AAH75795.1.

IPI

IPI00182469.
IPI00182540.
IPI00219725.
IPI00219726.
IPI00219727.
IPI00219728.
IPI00219730.
IPI00219731.
IPI00219732.
IPI00219733.
IPI00219734.
IPI00219735.
IPI00219737.
IPI00219738.
IPI00219739.
IPI00219741.
IPI00219742.
IPI00219743.
IPI00219744.
IPI00219745.
IPI00219746.
IPI00219747.
IPI00219748.
IPI00219749.
IPI00219750.
IPI00219869.
IPI00219870.
IPI00219872.
IPI00219873.
IPI00219875.
IPI00845519.
IPI00942869.

RefSeq

NP_001078927.1. NM_001085458.1.
NP_001078928.1. NM_001085459.1.
NP_001078929.1. NM_001085460.1.
NP_001078930.1. NM_001085461.1.
NP_001078931.1. NM_001085462.1.
NP_001078932.1. NM_001085463.1.
NP_001078933.1. NM_001085464.1.
NP_001078934.1. NM_001085465.1.
NP_001078935.1. NM_001085466.1.
NP_001078936.1. NM_001085467.1.
NP_001078937.1. NM_001085468.1.
NP_001078938.1. NM_001085469.1.
NP_001193812.1. NM_001206883.1.
NP_001193813.1. NM_001206884.1.
NP_001193814.1. NM_001206885.1.
NP_001193815.1. NM_001206886.1.
NP_001193816.1. NM_001206887.1.
NP_001193817.1. NM_001206888.1.
NP_001193818.1. NM_001206889.1.
NP_001193819.1. NM_001206890.1.
NP_001193820.1. NM_001206891.1.
NP_001322.1. NM_001331.2.

UniGene

Hs.166011.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3L6X	X-ray	2.40	A	324-937	[»]
3L6Y	X-ray	3.00	A/C/E	324-937	[»]

ProteinModelPortal

O60716.

SMR

O60716. Positions 358-852.

ModBase

Search...

Protein-protein interaction databases

IntAct

O60716. 14 interactions.

STRING

O60716.

PTM databases

PhosphoSite

O60716.

Proteomic databases

PRIDE

O60716.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000399050; ENSP00000382004; ENSG00000198561.

GeneID

1500.

KEGG

hsa:1500.

UCSC

uc001nlh.1. human.
uc001nli.2. human.
uc001nlj.2. human.
uc001nll.2. human.
uc001nlw.2. human.
uc001nlx.2. human.
uc001nly.2. human.
uc001nlz.2. human.
uc001nma.2. human.
uc001nmc.2. human.
uc001nmd.2. human.

Organism-specific databases

CTD

1500.

GeneCards

GC11P057531.

H-InvDB

HIX0009643.

HGNC

HGNC:2515. CTNND1.

HPA

CAB003837.
HPA015955.

MIM

601045. gene.

neXtProt

NX_O60716.

PharmGKB

PA27016.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG12799.

HOVERGEN

HBG004284.

InParanoid

O60716.

OMA

EVHLGAC.

PhylomeDB

O60716.

Enzyme and pathway databases

Pathway_Interaction_DB

arf6_traffickingpathway. Arf6 trafficking events.
fgf_pathway. FGF signaling pathway.

Reactome

REACT_111155. Cell-Cell communication.

Gene expression databases

ArrayExpress

O60716.

Bgee

O60716.

Genevestigator

O60716.

GermOnline

ENSG00000198561. Homo sapiens.

Family and domain databases

InterPro

IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]

Gene3D

G3DSA:1.25.10.10. ARM-like. 2 hits.

KO

K05690.

Pfam

PF00514. Arm. 3 hits.
[Graphical view]

SMART

SM00185. ARM. 6 hits.
[Graphical view]

SUPFAM

SSF48371. ARM-type_fold. 1 hit.

PROSITE

PS50176. ARM_REPEAT. 3 hits.
[Graphical view]

ProtoNet

Search...

Other

NextBio

6177.

SOURCE

Search...

Entry information

Entry name

CTND1_HUMAN

Accession

Primary (citable) accession number: O60716
Secondary accession number(s): A8K939 , O15088, O60713, O60714, O60715, O60935, Q6DHZ7, Q6RBX8, Q9UP71, Q9UP72, Q9UP73

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2001
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 116 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.