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Protein

Protein yippee-like 1

Gene

YPEL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May play a role in epithelioid conversion of fibroblasts.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi23 – 231ZincPROSITE-ProRule annotation
Metal bindingi26 – 261ZincPROSITE-ProRule annotation
Metal bindingi79 – 791ZincPROSITE-ProRule annotation
Metal bindingi82 – 821ZincPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein yippee-like 1
Gene namesi
Name:YPEL1
ORF Names:FKSG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:12845. YPEL1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37436.

Polymorphism and mutation databases

BioMutaiYPEL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 119119Protein yippee-like 1PRO_0000212381Add
BLAST

Proteomic databases

PaxDbiO60688.
PRIDEiO60688.

Expressioni

Gene expression databases

BgeeiO60688.
CleanExiHS_YPEL1.
ExpressionAtlasiO60688. baseline and differential.
GenevisibleiO60688. HS.

Organism-specific databases

HPAiHPA030501.
HPA045621.

Interactioni

Protein-protein interaction databases

BioGridi118923. 7 interactions.
STRINGi9606.ENSP00000342832.

Structurei

3D structure databases

ProteinModelPortaliO60688.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 11698YippeePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi99 – 1046Nuclear localization signalSequence analysis

Sequence similaritiesi

Belongs to the yippee family.Curated
Contains 1 Yippee domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3399. Eukaryota.
ENOG4111VJ1. LUCA.
GeneTreeiENSGT00390000008364.
HOGENOMiHOG000184254.
HOVERGENiHBG054215.
InParanoidiO60688.
OMAiSSHGRHI.
OrthoDBiEOG7TXKJJ.
PhylomeDBiO60688.
TreeFamiTF313936.

Family and domain databases

InterProiIPR004910. Yippee/Mis18/Cereblon.
[Graphical view]
PfamiPF03226. Yippee-Mis18. 1 hit.
[Graphical view]
PROSITEiPS51792. YIPPEE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60688-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKMTKSKTF QAYLPNCHRT YSCIHCRAHL ANHDELISKS FQGSQGRAYL
60 70 80 90 100
FNSVVNVGCG PAEERVLLTG LHAVADIYCE NCKTTLGWKY EHAFESSQKY
110
KEGKFIIELA HMIKDNGWE
Length:119
Mass (Da):13,575
Last modified:August 1, 1998 - v1
Checksum:iE91C058FA8C6D81F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti108 – 1081E → D in AAH74501 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098734 mRNA. Translation: BAD51375.1.
AB098735 mRNA. Translation: BAD51376.1.
AF060862 mRNA. Translation: AAC15461.1.
AF305069 mRNA. Translation: AAL09353.1.
CR456376 mRNA. Translation: CAG30262.1.
CR933630 Transcribed RNA. Translation: CAI45937.1.
BC034486 mRNA. Translation: AAH34486.1.
BC074501 mRNA. Translation: AAH74501.1.
CCDSiCCDS13794.1.
PIRiT50835.
RefSeqiNP_037445.1. NM_013313.4.
UniGeneiHs.517436.

Genome annotation databases

EnsembliENST00000339468; ENSP00000342832; ENSG00000100027.
GeneIDi29799.
KEGGihsa:29799.
UCSCiuc002zvl.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098734 mRNA. Translation: BAD51375.1.
AB098735 mRNA. Translation: BAD51376.1.
AF060862 mRNA. Translation: AAC15461.1.
AF305069 mRNA. Translation: AAL09353.1.
CR456376 mRNA. Translation: CAG30262.1.
CR933630 Transcribed RNA. Translation: CAI45937.1.
BC034486 mRNA. Translation: AAH34486.1.
BC074501 mRNA. Translation: AAH74501.1.
CCDSiCCDS13794.1.
PIRiT50835.
RefSeqiNP_037445.1. NM_013313.4.
UniGeneiHs.517436.

3D structure databases

ProteinModelPortaliO60688.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118923. 7 interactions.
STRINGi9606.ENSP00000342832.

Polymorphism and mutation databases

BioMutaiYPEL1.

Proteomic databases

PaxDbiO60688.
PRIDEiO60688.

Protocols and materials databases

DNASUi29799.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339468; ENSP00000342832; ENSG00000100027.
GeneIDi29799.
KEGGihsa:29799.
UCSCiuc002zvl.4. human.

Organism-specific databases

CTDi29799.
GeneCardsiYPEL1.
HGNCiHGNC:12845. YPEL1.
HPAiHPA030501.
HPA045621.
MIMi608082. gene.
neXtProtiNX_O60688.
PharmGKBiPA37436.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3399. Eukaryota.
ENOG4111VJ1. LUCA.
GeneTreeiENSGT00390000008364.
HOGENOMiHOG000184254.
HOVERGENiHBG054215.
InParanoidiO60688.
OMAiSSHGRHI.
OrthoDBiEOG7TXKJJ.
PhylomeDBiO60688.
TreeFamiTF313936.

Miscellaneous databases

GenomeRNAii29799.
NextBioi52343.
PROiO60688.
SOURCEiSearch...

Gene expression databases

BgeeiO60688.
CleanExiHS_YPEL1.
ExpressionAtlasiO60688. baseline and differential.
GenevisibleiO60688. HS.

Family and domain databases

InterProiIPR004910. Yippee/Mis18/Cereblon.
[Graphical view]
PfamiPF03226. Yippee-Mis18. 1 hit.
[Graphical view]
PROSITEiPS51792. YIPPEE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species."
    Hosono K., Sasaki T., Minoshima S., Shimizu N.
    Gene 340:31-43(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Human unknown cDNA, complete cds."
    Hu G., Hui L.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning and characterization of FKSG3, a novel gene related to DiGeorge syndrome."
    Wang Y.-G.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal kidney.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Testis.

Entry informationi

Entry nameiYPEL1_HUMAN
AccessioniPrimary (citable) accession number: O60688
Secondary accession number(s): Q65ZA1, Q6GLI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.