O60688 (YPEL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein yippee-like 1

Gene names

Name:	YPEL1
ORF Names:	FKSG3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	119 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in epithelioid conversion of fibroblasts.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the yippee family.

Ontologies

Keywords
Cellular component	Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 119	119	Protein yippee-like 1		PRO_0000212381
Regions
	Motif	99 – 104	6	Nuclear localization signal Potential
Experimental info
	Sequence conflict	108	1	E → D in AAH74501. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	O60688 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: E91C058FA8C6D81F	FASTA	119	13,575
	10 20 30 40 50 60 MVKMTKSKTF QAYLPNCHRT YSCIHCRAHL ANHDELISKS FQGSQGRAYL FNSVVNVGCG 70 80 90 100 110 PAEERVLLTG LHAVADIYCE NCKTTLGWKY EHAFESSQKY KEGKFIIELA HMIKDNGWE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species." Hosono K., Sasaki T., Minoshima S., Shimizu N. Gene 340:31-43(2004) [PubMed: 15556292] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Human unknown cDNA, complete cds." Hu G., Hui L. Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning and characterization of FKSG3, a novel gene related to DiGeorge syndrome." Wang Y.-G. Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed: 15461802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Fetal kidney.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB098734 mRNA. Translation: BAD51375.1. AB098735 mRNA. Translation: BAD51376.1. AF060862 mRNA. Translation: AAC15461.1. AF305069 mRNA. Translation: AAL09353.1. CR456376 mRNA. Translation: CAG30262.1. CR933630 Transcribed RNA. Translation: CAI45937.1. BC034486 mRNA. Translation: AAH34486.1. BC074501 mRNA. Translation: AAH74501.1.
IPI	IPI00743468.
PIR	T50835.
RefSeq	NP_037445.1. NM_013313.3.
UniGene	Hs.517436.
3D structure databases
ProteinModelPortal	O60688.
ModBase	Search...
Protein-protein interaction databases
STRING	O60688.
Proteomic databases
PRIDE	O60688.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000204279; ENSP00000204279; ENSG00000100027. ENST00000339468; ENSP00000342832; ENSG00000100027.
GeneID	29799.
KEGG	hsa:29799.
UCSC	uc002zvl.1. human.
Organism-specific databases
CTD	29799.
GeneCards	GC22M022051.
H-InvDB	HIX0203172.
HGNC	HGNC:12845. YPEL1.
HPA	HPA030501.
MIM	608082. gene.
neXtProt	NX_O60688.
PharmGKB	PA37436.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG04871.
GeneTree	ENSGT00390000008364.
HOGENOM	HBG524054.
HOVERGEN	HBG054215.
InParanoid	O60688.
OMA	CECCKTT.
OrthoDB	EOG4HQDKR.
PhylomeDB	O60688.
Gene expression databases
Bgee	O60688.
CleanEx	HS_YPEL1.
Genevestigator	O60688.
GermOnline	ENSG00000100027. Homo sapiens.
Family and domain databases
InterPro	IPR004910. Yippee. [Graphical view]
Pfam	PF03226. Yippee. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	52343.
SOURCE	Search...

Entry information

Entry name

YPEL1_HUMAN

Accession

Primary (citable) accession number: O60688
Secondary accession number(s): Q65ZA1, Q6GLI6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 17, 2003
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.