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Protein

Sushi repeat-containing protein SRPX2

Gene

SRPX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive development.4 Publications

GO - Molecular functioni

  • hepatocyte growth factor binding Source: UniProtKB
  • identical protein binding Source: UniProtKB
  • signaling receptor binding Source: UniProtKB

GO - Biological processi

  • angiogenesis Source: UniProtKB-KW
  • cell-cell adhesion Source: UniProtKB
  • cell motility Source: UniProtKB
  • positive regulation of cell migration involved in sprouting angiogenesis Source: UniProtKB
  • positive regulation of synapse assembly Source: UniProtKB
  • regulation of phosphorylation Source: UniProtKB
  • vocalization behavior Source: Ensembl

Keywordsi

Biological processAngiogenesis, Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Sushi repeat-containing protein SRPX2
Alternative name(s):
Sushi-repeat protein upregulated in leukemia
Gene namesi
Name:SRPX2
Synonyms:SRPUL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000102359.5
HGNCiHGNC:30668 SRPX2
MIMi300642 gene
neXtProtiNX_O60687

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Secreted, Synapse

Pathology & Biotechi

Involvement in diseasei

Rolandic epilepsy with speech dyspraxia and mental retardation X-linked (RESDX)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition characterized by the association of rolandic seizures with oral and speech dyspraxia, and mental retardation. Rolandic seizures occur during a period of significant brain maturation. During this time, dysfunction of neural network activities such as focal discharges may be associated with specific developmental disabilities resulting in specific cognitive impairments of language, visuo-spatial abilities or attention.
See also OMIM:300643
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03031272Y → S in RESDX; affects intracellular processing; increases the interaction with PLAUR. 1 PublicationCorresponds to variant dbSNP:rs121918364EnsemblClinVar.1
Natural variantiVAR_030314327N → S in RESDX; unknown pathological significance; results in a gain of glycosylation; affects intracellular processing; does not affect interaction with PLAUR. 1 PublicationCorresponds to variant dbSNP:rs121918363EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Epilepsy, Mental retardation

Organism-specific databases

DisGeNETi27286
MalaCardsiSRPX2
MIMi300643 phenotype
OpenTargetsiENSG00000102359
Orphaneti98889 Bilateral perisylvian polymicrogyria
1945 Rolandic epilepsy
163721 Rolandic epilepsy - speech dyspraxia
PharmGKBiPA134983994

Polymorphism and mutation databases

BioMutaiSRPX2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000027452524 – 465Sushi repeat-containing protein SRPX2Add BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi71 ↔ 105PROSITE-ProRule annotation
Disulfide bondi91 ↔ 117PROSITE-ProRule annotation
Disulfide bondi122 ↔ 163PROSITE-ProRule annotation
Disulfide bondi149 ↔ 176PROSITE-ProRule annotation
Disulfide bondi264 ↔ 306PROSITE-ProRule annotation
Disulfide bondi292 ↔ 319PROSITE-ProRule annotation

Post-translational modificationi

Contains chondroitin sulfate chains.

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

PaxDbiO60687
PeptideAtlasiO60687
PRIDEiO60687
ProteomicsDBi49528

PTM databases

iPTMnetiO60687
PhosphoSitePlusiO60687

Expressioni

Tissue specificityi

Expressed in neurons of the rolandic area of the brain (at protein level). Highly expressed in the brain, placenta, lung, trachea, uterus, adrenal gland, heart, ovary and placenta. Weakly expressed in the peripheral blood, brain and bone marrow. Expressed in numerous cancer cell lines and in gastrointestinal cancer cells. Higher levels found in colorectal cancers than in normal colonic mucosa.5 Publications

Gene expression databases

BgeeiENSG00000102359
CleanExiHS_SRPX2
ExpressionAtlasiO60687 baseline and differential
GenevisibleiO60687 HS

Organism-specific databases

HPAiHPA038786

Interactioni

Subunit structurei

Forms homooligomers (By similarity). Interacts with PLAUR (via the UPAR/Ly6 domains), ADAMTS4 and CTSB. Interacts with HGF; the interaction increases the mitogenic activity of HGF.By similarity3 Publications

GO - Molecular functioni

  • hepatocyte growth factor binding Source: UniProtKB
  • identical protein binding Source: UniProtKB
  • signaling receptor binding Source: UniProtKB

Protein-protein interaction databases

IntActiO60687, 2 interactors
STRINGi9606.ENSP00000362095

Structurei

3D structure databases

ProteinModelPortaliO60687
SMRiO60687
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 119Sushi 1PROSITE-ProRule annotationAdd BLAST51
Domaini120 – 178Sushi 2PROSITE-ProRule annotationAdd BLAST59
Domaini177 – 261HYRPROSITE-ProRule annotationAdd BLAST85
Domaini262 – 321Sushi 3PROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiENOG410IJCK Eukaryota
ENOG4110JE2 LUCA
GeneTreeiENSGT00910000144117
HOGENOMiHOG000232093
HOVERGENiHBG007217
InParanoidiO60687
KOiK19408
OMAiVQVRRCP
OrthoDBiEOG091G045R
PhylomeDBiO60687
TreeFamiTF336515

Family and domain databases

CDDicd00033 CCP, 3 hits
InterProiView protein in InterPro
IPR025232 DUF4174
IPR003410 HYR_dom
IPR028768 SRPX2
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PANTHERiPTHR19325:SF93 PTHR19325:SF93, 1 hit
PfamiView protein in Pfam
PF13778 DUF4174, 1 hit
PF02494 HYR, 1 hit
PF00084 Sushi, 3 hits
SMARTiView protein in SMART
SM00032 CCP, 3 hits
SUPFAMiSSF57535 SSF57535, 3 hits
PROSITEiView protein in PROSITE
PS50825 HYR, 1 hit
PS50923 SUSHI, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60687-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQLTQRGA LFLLFFLTPA VTPTWYAGSG YYPDESYNEV YAEEVPQAPA
60 70 80 90 100
LDYRVPRWCY TLNIQDGEAT CYSPKGGNYH SSLGTRCELS CDRGFRLIGR
110 120 130 140 150
RSVQCLPSRR WSGTAYCRQM RCHALPFITS GTYTCTNGVL LDSRCDYSCS
160 170 180 190 200
SGYHLEGDRS RICMEDGRWS GGEPVCVDID PPKIRCPHSR EKMAEPEKLT
210 220 230 240 250
ARVYWDPPLV KDSADGTITR VTLRGPEPGS HFPEGEHVIR YTAYDRAYNR
260 270 280 290 300
ASCKFIVKVQ VRRCPTLKPP QHGYLTCTSA GDNYGATCEY HCDGGYDRQG
310 320 330 340 350
TPSRVCQSSR QWSGSPPICA PMKINVNVNS AAGLLDQFYE KQRLLIISAP
360 370 380 390 400
DPSNRYYKMQ ISMLQQSTCG LDLRHVTIIE LVGQPPQEVG RIREQQLSAN
410 420 430 440 450
IIEELRQFQR LTRSYFNMVL IDKQGIDRDR YMEPVTPEEI FTFIDDYLLS
460
NQELTQRREQ RDICE
Length:465
Mass (Da):52,972
Last modified:August 1, 1998 - v1
Checksum:i4D752B187FF3EFB8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03031272Y → S in RESDX; affects intracellular processing; increases the interaction with PLAUR. 1 PublicationCorresponds to variant dbSNP:rs121918364EnsemblClinVar.1
Natural variantiVAR_030313287T → S1 PublicationCorresponds to variant dbSNP:rs17851822Ensembl.1
Natural variantiVAR_030314327N → S in RESDX; unknown pathological significance; results in a gain of glycosylation; affects intracellular processing; does not affect interaction with PLAUR. 1 PublicationCorresponds to variant dbSNP:rs121918363EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060567 mRNA Translation: AAC15765.1
AF393649 mRNA Translation: AAM73693.1
AK075462 mRNA Translation: BAG52145.1
AL035608 Genomic DNA No translation available.
AL390040 Genomic DNA No translation available.
BC020733 mRNA Translation: AAH20733.1
CCDSiCCDS14471.1
RefSeqiNP_055282.1, NM_014467.2
UniGeneiHs.306339

Genome annotation databases

EnsembliENST00000373004; ENSP00000362095; ENSG00000102359
GeneIDi27286
KEGGihsa:27286
UCSCiuc004egb.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSRPX2_HUMAN
AccessioniPrimary (citable) accession number: O60687
Secondary accession number(s): B3KQT3, Q8WW85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: August 1, 1998
Last modified: June 20, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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