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Protein

Sushi repeat-containing protein SRPX2

Gene

SRPX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive development.4 Publications

GO - Molecular functioni

  • hepatocyte growth factor binding Source: UniProtKB
  • identical protein binding Source: UniProtKB
  • receptor binding Source: UniProtKB

GO - Biological processi

  • angiogenesis Source: UniProtKB-KW
  • cell motility Source: UniProtKB
  • positive regulation of cell migration involved in sprouting angiogenesis Source: UniProtKB
  • positive regulation of synapse assembly Source: UniProtKB
  • regulation of phosphorylation Source: UniProtKB
  • single organismal cell-cell adhesion Source: UniProtKB
  • vocalization behavior Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Angiogenesis, Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Sushi repeat-containing protein SRPX2
Alternative name(s):
Sushi-repeat protein upregulated in leukemia
Gene namesi
Name:SRPX2
Synonyms:SRPUL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:30668. SRPX2.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • cell surface Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • excitatory synapse Source: UniProtKB
  • extracellular space Source: UniProtKB
  • synaptic membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Secreted, Synapse

Pathology & Biotechi

Involvement in diseasei

Rolandic epilepsy with speech dyspraxia and mental retardation X-linked (RESDX)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition characterized by the association of rolandic seizures with oral and speech dyspraxia, and mental retardation. Rolandic seizures occur during a period of significant brain maturation. During this time, dysfunction of neural network activities such as focal discharges may be associated with specific developmental disabilities resulting in specific cognitive impairments of language, visuo-spatial abilities or attention.
See also OMIM:300643
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti72 – 721Y → S in RESDX; affects intracellular processing; increases the interaction with PLAUR. 1 Publication
Corresponds to variant rs121918364 [ dbSNP | Ensembl ].
VAR_030312
Natural varianti327 – 3271N → S in RESDX; results in a gain of glycosylation; affects intracellular processing; does not affect interaction with PLAUR. 1 Publication
Corresponds to variant rs121918363 [ dbSNP | Ensembl ].
VAR_030314

Keywords - Diseasei

Disease mutation, Epilepsy, Mental retardation

Organism-specific databases

MalaCardsiSRPX2.
MIMi300643. phenotype.
Orphaneti98889. Bilateral perisylvian polymicrogyria.
1945. Rolandic epilepsy.
163721. Rolandic epilepsy - speech dyspraxia.
PharmGKBiPA134983994.

Polymorphism and mutation databases

BioMutaiSRPX2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 465442Sushi repeat-containing protein SRPX2PRO_0000274525Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi71 ↔ 105PROSITE-ProRule annotation
Disulfide bondi91 ↔ 117PROSITE-ProRule annotation
Disulfide bondi122 ↔ 163PROSITE-ProRule annotation
Disulfide bondi149 ↔ 176PROSITE-ProRule annotation
Disulfide bondi264 ↔ 306PROSITE-ProRule annotation
Disulfide bondi292 ↔ 319PROSITE-ProRule annotation

Post-translational modificationi

Contains chondroitin sulfate chains.

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

PaxDbiO60687.
PeptideAtlasiO60687.
PRIDEiO60687.

PTM databases

iPTMnetiO60687.
PhosphoSiteiO60687.

Expressioni

Tissue specificityi

Expressed in neurons of the rolandic area of the brain (at protein level). Highly expressed in the brain, placenta, lung, trachea, uterus, adrenal gland, heart, ovary and placenta. Weakly expressed in the peripheral blood, brain and bone marrow. Expressed in numerous cancer cell lines and in gastrointestinal cancer cells. Higher levels found in colorectal cancers than in normal colonic mucosa.5 Publications

Gene expression databases

BgeeiENSG00000102359.
CleanExiHS_SRPX2.
GenevisibleiO60687. HS.

Organism-specific databases

HPAiHPA038786.

Interactioni

Subunit structurei

Forms homooligomers (By similarity). Interacts with PLAUR (via the UPAR/Ly6 domains), ADAMTS4 and CTSB. Interacts with HGF; the interaction increases the mitogenic activity of HGF.By similarity3 Publications

GO - Molecular functioni

  • hepatocyte growth factor binding Source: UniProtKB
  • identical protein binding Source: UniProtKB
  • receptor binding Source: UniProtKB

Protein-protein interaction databases

IntActiO60687. 2 interactions.
MINTiMINT-7034515.
STRINGi9606.ENSP00000362095.

Structurei

3D structure databases

ProteinModelPortaliO60687.
SMRiO60687. Positions 65-178, 260-338.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini69 – 11951Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini120 – 17859Sushi 2PROSITE-ProRule annotationAdd
BLAST
Domaini177 – 26185HYRPROSITE-ProRule annotationAdd
BLAST
Domaini262 – 32160Sushi 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HYR domain.PROSITE-ProRule annotation
Contains 3 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiENOG410IJCK. Eukaryota.
ENOG4110JE2. LUCA.
GeneTreeiENSGT00730000110685.
HOGENOMiHOG000232093.
HOVERGENiHBG007217.
InParanoidiO60687.
KOiK19408.
OMAiTRCELSC.
OrthoDBiEOG091G045R.
PhylomeDBiO60687.
TreeFamiTF336515.

Family and domain databases

InterProiIPR025232. DUF4174.
IPR003410. HYR_dom.
IPR028768. SRPX2.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PANTHERiPTHR19325:SF93. PTHR19325:SF93. 1 hit.
PfamiPF13778. DUF4174. 1 hit.
PF02494. HYR. 1 hit.
PF00084. Sushi. 3 hits.
[Graphical view]
SMARTiSM00032. CCP. 3 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 3 hits.
PROSITEiPS50825. HYR. 1 hit.
PS50923. SUSHI. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60687-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQLTQRGA LFLLFFLTPA VTPTWYAGSG YYPDESYNEV YAEEVPQAPA
60 70 80 90 100
LDYRVPRWCY TLNIQDGEAT CYSPKGGNYH SSLGTRCELS CDRGFRLIGR
110 120 130 140 150
RSVQCLPSRR WSGTAYCRQM RCHALPFITS GTYTCTNGVL LDSRCDYSCS
160 170 180 190 200
SGYHLEGDRS RICMEDGRWS GGEPVCVDID PPKIRCPHSR EKMAEPEKLT
210 220 230 240 250
ARVYWDPPLV KDSADGTITR VTLRGPEPGS HFPEGEHVIR YTAYDRAYNR
260 270 280 290 300
ASCKFIVKVQ VRRCPTLKPP QHGYLTCTSA GDNYGATCEY HCDGGYDRQG
310 320 330 340 350
TPSRVCQSSR QWSGSPPICA PMKINVNVNS AAGLLDQFYE KQRLLIISAP
360 370 380 390 400
DPSNRYYKMQ ISMLQQSTCG LDLRHVTIIE LVGQPPQEVG RIREQQLSAN
410 420 430 440 450
IIEELRQFQR LTRSYFNMVL IDKQGIDRDR YMEPVTPEEI FTFIDDYLLS
460
NQELTQRREQ RDICE
Length:465
Mass (Da):52,972
Last modified:August 1, 1998 - v1
Checksum:i4D752B187FF3EFB8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti72 – 721Y → S in RESDX; affects intracellular processing; increases the interaction with PLAUR. 1 Publication
Corresponds to variant rs121918364 [ dbSNP | Ensembl ].
VAR_030312
Natural varianti287 – 2871T → S.1 Publication
Corresponds to variant rs17851822 [ dbSNP | Ensembl ].
VAR_030313
Natural varianti327 – 3271N → S in RESDX; results in a gain of glycosylation; affects intracellular processing; does not affect interaction with PLAUR. 1 Publication
Corresponds to variant rs121918363 [ dbSNP | Ensembl ].
VAR_030314

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060567 mRNA. Translation: AAC15765.1.
AF393649 mRNA. Translation: AAM73693.1.
AK075462 mRNA. Translation: BAG52145.1.
AL035608 Genomic DNA. No translation available.
AL390040 Genomic DNA. No translation available.
BC020733 mRNA. Translation: AAH20733.1.
CCDSiCCDS14471.1.
RefSeqiNP_055282.1. NM_014467.2.
UniGeneiHs.306339.

Genome annotation databases

EnsembliENST00000373004; ENSP00000362095; ENSG00000102359.
GeneIDi27286.
KEGGihsa:27286.
UCSCiuc004egb.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060567 mRNA. Translation: AAC15765.1.
AF393649 mRNA. Translation: AAM73693.1.
AK075462 mRNA. Translation: BAG52145.1.
AL035608 Genomic DNA. No translation available.
AL390040 Genomic DNA. No translation available.
BC020733 mRNA. Translation: AAH20733.1.
CCDSiCCDS14471.1.
RefSeqiNP_055282.1. NM_014467.2.
UniGeneiHs.306339.

3D structure databases

ProteinModelPortaliO60687.
SMRiO60687. Positions 65-178, 260-338.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO60687. 2 interactions.
MINTiMINT-7034515.
STRINGi9606.ENSP00000362095.

PTM databases

iPTMnetiO60687.
PhosphoSiteiO60687.

Polymorphism and mutation databases

BioMutaiSRPX2.

Proteomic databases

PaxDbiO60687.
PeptideAtlasiO60687.
PRIDEiO60687.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373004; ENSP00000362095; ENSG00000102359.
GeneIDi27286.
KEGGihsa:27286.
UCSCiuc004egb.4. human.

Organism-specific databases

CTDi27286.
GeneCardsiSRPX2.
HGNCiHGNC:30668. SRPX2.
HPAiHPA038786.
MalaCardsiSRPX2.
MIMi300642. gene.
300643. phenotype.
neXtProtiNX_O60687.
Orphaneti98889. Bilateral perisylvian polymicrogyria.
1945. Rolandic epilepsy.
163721. Rolandic epilepsy - speech dyspraxia.
PharmGKBiPA134983994.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJCK. Eukaryota.
ENOG4110JE2. LUCA.
GeneTreeiENSGT00730000110685.
HOGENOMiHOG000232093.
HOVERGENiHBG007217.
InParanoidiO60687.
KOiK19408.
OMAiTRCELSC.
OrthoDBiEOG091G045R.
PhylomeDBiO60687.
TreeFamiTF336515.

Miscellaneous databases

GeneWikiiSRPX2.
GenomeRNAii27286.
PROiO60687.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102359.
CleanExiHS_SRPX2.
GenevisibleiO60687. HS.

Family and domain databases

InterProiIPR025232. DUF4174.
IPR003410. HYR_dom.
IPR028768. SRPX2.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PANTHERiPTHR19325:SF93. PTHR19325:SF93. 1 hit.
PfamiPF13778. DUF4174. 1 hit.
PF02494. HYR. 1 hit.
PF00084. Sushi. 3 hits.
[Graphical view]
SMARTiSM00032. CCP. 3 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 3 hits.
PROSITEiPS50825. HYR. 1 hit.
PS50923. SUSHI. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRPX2_HUMAN
AccessioniPrimary (citable) accession number: O60687
Secondary accession number(s): B3KQT3, Q8WW85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.