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Protein

Importin subunit alpha-7

Gene

KPNA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000025800-MONOMER.
SignaLinkiO60684.
SIGNORiO60684.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Importin subunit alpha-7
Alternative name(s):
Karyopherin subunit alpha-6
Gene namesi
Name:KPNA6
Synonyms:IPOA7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:6399. KPNA6.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GO_Central
  • membrane Source: UniProtKB
  • nuclear pore Source: GO_Central
  • nucleoplasm Source: GO_Central
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi23633.
OpenTargetsiENSG00000025800.
PharmGKBiPA30190.

Polymorphism and mutation databases

BioMutaiKPNA6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001207291 – 536Importin subunit alpha-7Add BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei6PhosphoserineCombined sources1
Modified residuei113PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO60684.
MaxQBiO60684.
PaxDbiO60684.
PeptideAtlasiO60684.
PRIDEiO60684.

PTM databases

iPTMnetiO60684.
PhosphoSitePlusiO60684.
SwissPalmiO60684.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000025800.
CleanExiHS_KPNA6.
ExpressionAtlasiO60684. baseline and differential.
GenevisibleiO60684. HS.

Organism-specific databases

HPAiHPA018863.

Interactioni

Subunit structurei

Interacts with ZIC3 (By similarity). Forms a complex with importin subunit beta-1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NOP2P460873EBI-359923,EBI-356811
NUP50Q9UKX75EBI-359923,EBI-2371082
SF1Q156374EBI-359923,EBI-744603
TAF9Q165943EBI-359923,EBI-712521

Protein-protein interaction databases

BioGridi117163. 69 interactors.
DIPiDIP-27609N.
IntActiO60684. 41 interactors.
MINTiMINT-1144956.
STRINGi9606.ENSP00000362728.

Structurei

Secondary structure

1536
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi83 – 89Combined sources7
Helixi94 – 108Combined sources15
Beta strandi111 – 113Combined sources3
Helixi116 – 121Combined sources6
Helixi125 – 132Combined sources8
Helixi139 – 152Combined sources14
Helixi157 – 165Combined sources9
Helixi168 – 174Combined sources7
Helixi175 – 177Combined sources3
Helixi181 – 195Combined sources15
Helixi199 – 207Combined sources9
Helixi211 – 220Combined sources10
Helixi224 – 238Combined sources15
Helixi247 – 249Combined sources3
Helixi251 – 253Combined sources3
Helixi254 – 260Combined sources7
Helixi266 – 279Combined sources14
Beta strandi281 – 283Combined sources3
Helixi284 – 292Combined sources9
Helixi296 – 301Combined sources6
Helixi302 – 304Combined sources3
Helixi308 – 321Combined sources14
Helixi326 – 333Combined sources8
Turni334 – 336Combined sources3
Helixi338 – 344Combined sources7
Helixi350 – 363Combined sources14
Helixi368 – 376Combined sources9
Helixi380 – 389Combined sources10
Helixi392 – 408Combined sources17
Helixi411 – 419Combined sources9
Helixi423 – 427Combined sources5
Helixi428 – 431Combined sources4
Helixi435 – 455Combined sources21
Turni456 – 459Combined sources4
Helixi467 – 472Combined sources6
Helixi475 – 481Combined sources7
Helixi482 – 484Combined sources3
Helixi488 – 501Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UADX-ray2.42A59-536[»]
ProteinModelPortaliO60684.
SMRiO60684.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 60IBBPROSITE-ProRule annotationAdd BLAST60
Repeati76 – 115ARM 1; truncatedAdd BLAST40
Repeati116 – 159ARM 2Add BLAST44
Repeati160 – 204ARM 3Add BLAST45
Repeati205 – 243ARM 4Add BLAST39
Repeati244 – 288ARM 5Add BLAST45
Repeati289 – 328ARM 6Add BLAST40
Repeati329 – 370ARM 7Add BLAST42
Repeati371 – 410ARM 8Add BLAST40
Repeati411 – 453ARM 9Add BLAST43
Repeati457 – 502ARM 10; atypicalAdd BLAST46

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni147 – 239NLS binding site (major)By similarityAdd BLAST93
Regioni316 – 404NLS binding site (minor)By similarityAdd BLAST89

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 54Nuclear localization signalBy similarity10

Sequence similaritiesi

Belongs to the importin alpha family.Curated
Contains 10 ARM repeats.PROSITE-ProRule annotation
Contains 1 IBB domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0166. Eukaryota.
COG5064. LUCA.
GeneTreeiENSGT00760000119094.
HOVERGENiHBG001846.
InParanoidiO60684.
OMAiHNDNKVA.
OrthoDBiEOG091G095Z.
PhylomeDBiO60684.
TreeFamiTF354205.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR032413. Arm_3.
IPR000225. Armadillo.
IPR002652. Importin-a_IBB.
IPR024931. Importing_su_alpha.
[Graphical view]
PfamiPF00514. Arm. 8 hits.
PF16186. Arm_3. 1 hit.
PF01749. IBB. 1 hit.
[Graphical view]
PIRSFiPIRSF005673. Importin_alpha. 1 hit.
SMARTiSM00185. ARM. 8 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
PS51214. IBB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60684-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METMASPGKD NYRMKSYKNN ALNPEEMRRR REEEGIQLRK QKREQQLFKR
60 70 80 90 100
RNVELINEEA AMFDSLLMDS YVSSTTGESV ITREMVEMLF SDDSDLQLAT
110 120 130 140 150
TQKFRKLLSK EPSPPIDEVI NTPRVVDRFV EFLKRNENCT LQFEAAWALT
160 170 180 190 200
NIASGTSQQT KIVIEAGAVP IFIELLNSDF EDVQEQAVWA LGNIAGDSSV
210 220 230 240 250
CRDYVLNCSI LNPLLTLLTK STRLTMTRNA VWALSNLCRG KNPPPEFAKV
260 270 280 290 300
SPCLPVLSRL LFSSDSDLLA DACWALSYLS DGPNEKIQAV IDSGVCRRLV
310 320 330 340 350
ELLMHNDYKV ASPALRAVGN IVTGDDIQTQ VILNCSALPC LLHLLSSPKE
360 370 380 390 400
SIRKEACWTI SNITAGNRAQ IQAVIDANIF PVLIEILQKA EFRTRKEAAW
410 420 430 440 450
AITNATSGGT PEQIRYLVSL GCIKPLCDLL TVMDSKIVQV ALNGLENILR
460 470 480 490 500
LGEQEGKRSG SGVNPYCGLI EEAYGLDKIE FLQSHENQEI YQKAFDLIEH
510 520 530
YFGVEDDDSS LAPQVDETQQ QFIFQQPEAP MEGFQL
Length:536
Mass (Da):60,030
Last modified:August 1, 1998 - v1
Checksum:i9D0E27482B9BDED3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060543 mRNA. Translation: AAC15233.1.
AK315490 mRNA. Translation: BAG37874.1.
BT009843 mRNA. Translation: AAP88845.1.
AL445248, AL049795 Genomic DNA. Translation: CAH71948.1.
AL049795, AL445248 Genomic DNA. Translation: CAI22056.1.
CH471059 Genomic DNA. Translation: EAX07567.1.
CH471059 Genomic DNA. Translation: EAX07568.1.
BC020520 mRNA. Translation: AAH20520.1.
CCDSiCCDS352.1.
RefSeqiNP_036448.1. NM_012316.4.
UniGeneiHs.470588.
Hs.711019.

Genome annotation databases

EnsembliENST00000373625; ENSP00000362728; ENSG00000025800.
GeneIDi23633.
KEGGihsa:23633.
UCSCiuc001bug.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060543 mRNA. Translation: AAC15233.1.
AK315490 mRNA. Translation: BAG37874.1.
BT009843 mRNA. Translation: AAP88845.1.
AL445248, AL049795 Genomic DNA. Translation: CAH71948.1.
AL049795, AL445248 Genomic DNA. Translation: CAI22056.1.
CH471059 Genomic DNA. Translation: EAX07567.1.
CH471059 Genomic DNA. Translation: EAX07568.1.
BC020520 mRNA. Translation: AAH20520.1.
CCDSiCCDS352.1.
RefSeqiNP_036448.1. NM_012316.4.
UniGeneiHs.470588.
Hs.711019.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UADX-ray2.42A59-536[»]
ProteinModelPortaliO60684.
SMRiO60684.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117163. 69 interactors.
DIPiDIP-27609N.
IntActiO60684. 41 interactors.
MINTiMINT-1144956.
STRINGi9606.ENSP00000362728.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

PTM databases

iPTMnetiO60684.
PhosphoSitePlusiO60684.
SwissPalmiO60684.

Polymorphism and mutation databases

BioMutaiKPNA6.

Proteomic databases

EPDiO60684.
MaxQBiO60684.
PaxDbiO60684.
PeptideAtlasiO60684.
PRIDEiO60684.

Protocols and materials databases

DNASUi23633.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373625; ENSP00000362728; ENSG00000025800.
GeneIDi23633.
KEGGihsa:23633.
UCSCiuc001bug.4. human.

Organism-specific databases

CTDi23633.
DisGeNETi23633.
GeneCardsiKPNA6.
HGNCiHGNC:6399. KPNA6.
HPAiHPA018863.
MIMi610563. gene.
neXtProtiNX_O60684.
OpenTargetsiENSG00000025800.
PharmGKBiPA30190.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0166. Eukaryota.
COG5064. LUCA.
GeneTreeiENSGT00760000119094.
HOVERGENiHBG001846.
InParanoidiO60684.
OMAiHNDNKVA.
OrthoDBiEOG091G095Z.
PhylomeDBiO60684.
TreeFamiTF354205.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000025800-MONOMER.
SignaLinkiO60684.
SIGNORiO60684.

Miscellaneous databases

ChiTaRSiKPNA6. human.
GeneWikiiKPNA6.
GenomeRNAii23633.
PROiO60684.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000025800.
CleanExiHS_KPNA6.
ExpressionAtlasiO60684. baseline and differential.
GenevisibleiO60684. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR032413. Arm_3.
IPR000225. Armadillo.
IPR002652. Importin-a_IBB.
IPR024931. Importing_su_alpha.
[Graphical view]
PfamiPF00514. Arm. 8 hits.
PF16186. Arm_3. 1 hit.
PF01749. IBB. 1 hit.
[Graphical view]
PIRSFiPIRSF005673. Importin_alpha. 1 hit.
SMARTiSM00185. ARM. 8 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
PS51214. IBB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIMA7_HUMAN
AccessioniPrimary (citable) accession number: O60684
Secondary accession number(s): B2RDC7, D3DPP5, Q5VVU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.