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Protein

Cystatin-8

Gene

CST8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Performs a specialized role during sperm development and maturation.

GO - Molecular functioni

  • cysteine-type endopeptidase inhibitor activity Source: ProtInc
  • protease binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125815-MONOMER.

Protein family/group databases

MEROPSiI25.027.

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-8
Alternative name(s):
Cystatin-related epididymal spermatogenic protein
Gene namesi
Name:CST8
Synonyms:CRES
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:2480. CST8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi10047.
OpenTargetsiENSG00000125815.
PharmGKBiPA26981.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000665322 – 142Cystatin-8Add BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi27N-linked (GlcNAc...)Sequence analysis1
Glycosylationi39N-linked (GlcNAc...)1 Publication1
Disulfide bondi95 ↔ 105By similarity
Disulfide bondi119 ↔ 139By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO60676.
PeptideAtlasiO60676.
PRIDEiO60676.

PTM databases

iPTMnetiO60676.
PhosphoSitePlusiO60676.

Expressioni

Tissue specificityi

Proximal caput region of the epididymis. Lower expression in the testis. Within the testis it is localized to the elongating spermatids, whereas within the epididymis it is exclusively synthesized by the proximal caput epithelium.

Gene expression databases

BgeeiENSG00000125815.
CleanExiHS_CST8.
ExpressionAtlasiO60676. baseline and differential.
GenevisibleiO60676. HS.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000246012.

Structurei

3D structure databases

ProteinModelPortaliO60676.
SMRiO60676.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi77 – 81Secondary area of contactSequence analysis5

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXH4. Eukaryota.
ENOG41113F6. LUCA.
GeneTreeiENSGT00860000133739.
HOGENOMiHOG000231754.
HOVERGENiHBG095685.
InParanoidiO60676.
KOiK13904.
OMAiKQCLWFA.
OrthoDBiEOG091G0TP1.
PhylomeDBiO60676.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiIPR027214. Cystatin.
IPR000010. Cystatin_dom.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 1 hit.
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
SMARTiSM00043. CY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60676-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRCRWLSLI LLTIPLALVA RKDPKKNETG VLRKLKPVNA SNANVKQCLW
60 70 80 90 100
FAMQEYNKES EDKYVFLVVK TLQAQLQVTN LLEYLIDVEI ARSDCRKPLS
110 120 130 140
TNEICAIQEN SKLKRKLSCS FLVGALPWNG EFTVMEKKCE DA
Length:142
Mass (Da):16,275
Last modified:August 1, 1998 - v1
Checksum:i9A3512757E0F4ECD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06113052A → V.Corresponds to variant rs35190670dbSNPEnsembl.1
Natural variantiVAR_014527142A → P.Corresponds to variant rs1054633dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059244 mRNA. Translation: AAC14707.1.
AL109954 Genomic DNA. Translation: CAB64234.1.
BC069496 mRNA. Translation: AAH69496.1.
BC105113 mRNA. Translation: AAI05114.1.
BC105119 mRNA. Translation: AAI05120.1.
CCDSiCCDS13156.1.
RefSeqiNP_001268659.1. NM_001281730.1.
NP_005483.1. NM_005492.3.
UniGeneiHs.121602.

Genome annotation databases

EnsembliENST00000246012; ENSP00000246012; ENSG00000125815.
GeneIDi10047.
KEGGihsa:10047.
UCSCiuc002wth.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059244 mRNA. Translation: AAC14707.1.
AL109954 Genomic DNA. Translation: CAB64234.1.
BC069496 mRNA. Translation: AAH69496.1.
BC105113 mRNA. Translation: AAI05114.1.
BC105119 mRNA. Translation: AAI05120.1.
CCDSiCCDS13156.1.
RefSeqiNP_001268659.1. NM_001281730.1.
NP_005483.1. NM_005492.3.
UniGeneiHs.121602.

3D structure databases

ProteinModelPortaliO60676.
SMRiO60676.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000246012.

Protein family/group databases

MEROPSiI25.027.

PTM databases

iPTMnetiO60676.
PhosphoSitePlusiO60676.

Proteomic databases

PaxDbiO60676.
PeptideAtlasiO60676.
PRIDEiO60676.

Protocols and materials databases

DNASUi10047.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246012; ENSP00000246012; ENSG00000125815.
GeneIDi10047.
KEGGihsa:10047.
UCSCiuc002wth.3. human.

Organism-specific databases

CTDi10047.
DisGeNETi10047.
GeneCardsiCST8.
HGNCiHGNC:2480. CST8.
MIMi608683. gene.
neXtProtiNX_O60676.
OpenTargetsiENSG00000125815.
PharmGKBiPA26981.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXH4. Eukaryota.
ENOG41113F6. LUCA.
GeneTreeiENSGT00860000133739.
HOGENOMiHOG000231754.
HOVERGENiHBG095685.
InParanoidiO60676.
KOiK13904.
OMAiKQCLWFA.
OrthoDBiEOG091G0TP1.
PhylomeDBiO60676.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125815-MONOMER.

Miscellaneous databases

GeneWikiiCST8_(gene).
GenomeRNAii10047.
PROiO60676.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125815.
CleanExiHS_CST8.
ExpressionAtlasiO60676. baseline and differential.
GenevisibleiO60676. HS.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiIPR027214. Cystatin.
IPR000010. Cystatin_dom.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 1 hit.
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
SMARTiSM00043. CY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCST8_HUMAN
AccessioniPrimary (citable) accession number: O60676
Secondary accession number(s): Q2M2X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.