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Protein

Transcription factor MafK

Gene

MAFK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-983231. Factors involved in megakaryocyte development and platelet production.
SIGNORiO60675.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor MafK
Alternative name(s):
Erythroid transcription factor NF-E2 p18 subunit
Gene namesi
Name:MAFK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000198517.9.
HGNCiHGNC:6782. MAFK.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7975.
OpenTargetsiENSG00000198517.
PharmGKBiPA30540.

Chemistry databases

ChEMBLiCHEMBL2346484.

Polymorphism and mutation databases

BioMutaiMAFK.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000765031 – 156Transcription factor MafKAdd BLAST156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei25PhosphoserineCombined sources1
Cross-linki130Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO60675.
MaxQBiO60675.
PaxDbiO60675.
PeptideAtlasiO60675.
PRIDEiO60675.

PTM databases

iPTMnetiO60675.
PhosphoSitePlusiO60675.

Expressioni

Gene expression databases

BgeeiENSG00000198517.
CleanExiHS_MAFK.
ExpressionAtlasiO60675. baseline and differential.
GenevisibleiO60675. HS.

Organism-specific databases

HPAiCAB026820.
HPA060841.

Interactioni

Subunit structurei

Homodimer or heterodimer. It can form high affinity heterodimers with members of the CNC-bZIP family such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3.

Binary interactionsi

WithEntry#Exp.IntActNotes
NFE2L2Q162363EBI-2559512,EBI-2007911

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113688. 18 interactors.
IntActiO60675. 4 interactors.
STRINGi9606.ENSP00000344903.

Structurei

3D structure databases

ProteinModelPortaliO60675.
SMRiO60675.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 114bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 76Basic motifPROSITE-ProRule annotationAdd BLAST26
Regioni79 – 93Leucine-zipperPROSITE-ProRule annotationAdd BLAST15

Sequence similaritiesi

Belongs to the bZIP family. Maf subfamily.Curated

Phylogenomic databases

eggNOGiENOG410ISHX. Eukaryota.
ENOG4111MYK. LUCA.
GeneTreeiENSGT00550000074549.
HOVERGENiHBG001725.
InParanoidiO60675.
KOiK09037.
OMAiLQCFART.
OrthoDBiEOG091G0H46.
PhylomeDBiO60675.
TreeFamiTF325689.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiView protein in InterPro
IPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR028574. MafK.
IPR008917. TF_DNA-bd_sf.
IPR024874. Transciption_factor_Maf_fam.
PANTHERiPTHR10129. PTHR10129. 1 hit.
PTHR10129:SF26. PTHR10129:SF26. 1 hit.
PfamiView protein in Pfam
PF03131. bZIP_Maf. 1 hit.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.

Sequencei

Sequence statusi: Complete.

O60675-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTNPKPNKA LKVKKEAGEN APVLSDDELV SMSVRELNQH LRGLTKEEVT
60 70 80 90 100
RLKQRRRTLK NRGYAASCRI KRVTQKEELE RQRVELQQEV EKLARENSSM
110 120 130 140 150
RLELDALRSK YEALQTFART VARGPVAPSK VATTSVITIV KSTELSSTSV

PFSAAS
Length:156
Mass (Da):17,523
Last modified:August 1, 1998 - v1
Checksum:i39F98F8D550C168E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059194 mRNA. Translation: AAC14426.1.
AK092414 mRNA. Translation: BAG52549.1.
AC093734 Genomic DNA. Translation: AAP21866.1.
CH236953 Genomic DNA. Translation: EAL23943.1.
CH471144 Genomic DNA. Translation: EAW87207.1.
BC148265 mRNA. Translation: AAI48266.1.
CCDSiCCDS5325.1.
RefSeqiNP_002351.1. NM_002360.3.
XP_005249908.2. XM_005249851.2.
XP_006715836.1. XM_006715773.2.
UniGeneiHs.520612.

Genome annotation databases

EnsembliENST00000343242; ENSP00000344903; ENSG00000198517.
ENST00000403150; ENSP00000386009; ENSG00000198517.
ENST00000406174; ENSP00000385437; ENSG00000198517.
GeneIDi7975.
KEGGihsa:7975.
UCSCiuc003skr.4. human.

Similar proteinsi

Entry informationi

Entry nameiMAFK_HUMAN
AccessioniPrimary (citable) accession number: O60675
Secondary accession number(s): A4D214
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: August 1, 1998
Last modified: November 22, 2017
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families