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Protein

Transcription factor MafK

Gene

MAFK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:9150357). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites (PubMed:9150357, PubMed:8932385). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor (PubMed:9150357).2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-983231 Factors involved in megakaryocyte development and platelet production
SIGNORiO60675

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor MafK
Alternative name(s):
Erythroid transcription factor NF-E2 p18 subunit
Gene namesi
Name:MAFK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000198517.9
HGNCiHGNC:6782 MAFK
MIMi600197 gene
neXtProtiNX_O60675

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7975
OpenTargetsiENSG00000198517
PharmGKBiPA30540

Chemistry databases

ChEMBLiCHEMBL2346484

Polymorphism and mutation databases

BioMutaiMAFK

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000765031 – 156Transcription factor MafKAdd BLAST156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei25PhosphoserineCombined sources1
Modified residuei53N6-acetyllysineBy similarity1
Modified residuei60N6-acetyllysineBy similarity1
Modified residuei71N6-acetyllysineBy similarity1
Modified residuei76N6-acetyllysineBy similarity1
Cross-linki130Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO60675
MaxQBiO60675
PaxDbiO60675
PeptideAtlasiO60675
PRIDEiO60675

PTM databases

iPTMnetiO60675
PhosphoSitePlusiO60675

Expressioni

Gene expression databases

BgeeiENSG00000198517
CleanExiHS_MAFK
ExpressionAtlasiO60675 baseline and differential
GenevisibleiO60675 HS

Organism-specific databases

HPAiCAB026820
HPA060841

Interactioni

Subunit structurei

Homodimer or heterodimer. It can form high affinity heterodimers with members of the CNC-bZIP family such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3 (PubMed:9150357, PubMed:8932385).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NFE2L2Q162363EBI-2559512,EBI-2007911

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113688, 18 interactors
IntActiO60675, 4 interactors
STRINGi9606.ENSP00000344903

Structurei

3D structure databases

ProteinModelPortaliO60675
SMRiO60675
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 114bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 76Basic motifPROSITE-ProRule annotationAdd BLAST26
Regioni79 – 93Leucine-zipperPROSITE-ProRule annotationAdd BLAST15

Sequence similaritiesi

Belongs to the bZIP family. Maf subfamily.Curated

Phylogenomic databases

eggNOGiENOG410ISHX Eukaryota
ENOG4111MYK LUCA
GeneTreeiENSGT00550000074549
HOVERGENiHBG001725
InParanoidiO60675
KOiK09037
OMAiLQCFART
OrthoDBiEOG091G0H46
PhylomeDBiO60675
TreeFamiTF325689

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR004826 bZIP_Maf
IPR028574 MafK
IPR008917 TF_DNA-bd_sf
IPR024874 Transciption_factor_Maf_fam
PANTHERiPTHR10129 PTHR10129, 1 hit
PTHR10129:SF26 PTHR10129:SF26, 1 hit
PfamiView protein in Pfam
PF03131 bZIP_Maf, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit

Sequencei

Sequence statusi: Complete.

O60675-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTNPKPNKA LKVKKEAGEN APVLSDDELV SMSVRELNQH LRGLTKEEVT
60 70 80 90 100
RLKQRRRTLK NRGYAASCRI KRVTQKEELE RQRVELQQEV EKLARENSSM
110 120 130 140 150
RLELDALRSK YEALQTFART VARGPVAPSK VATTSVITIV KSTELSSTSV

PFSAAS
Length:156
Mass (Da):17,523
Last modified:August 1, 1998 - v1
Checksum:i39F98F8D550C168E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059194 mRNA Translation: AAC14426.1
AK092414 mRNA Translation: BAG52549.1
AC093734 Genomic DNA Translation: AAP21866.1
CH236953 Genomic DNA Translation: EAL23943.1
CH471144 Genomic DNA Translation: EAW87207.1
BC148265 mRNA Translation: AAI48266.1
CCDSiCCDS5325.1
RefSeqiNP_002351.1, NM_002360.3
XP_005249908.2, XM_005249851.2
XP_006715836.1, XM_006715773.2
UniGeneiHs.520612

Genome annotation databases

EnsembliENST00000343242; ENSP00000344903; ENSG00000198517
ENST00000403150; ENSP00000386009; ENSG00000198517
ENST00000406174; ENSP00000385437; ENSG00000198517
GeneIDi7975
KEGGihsa:7975
UCSCiuc003skr.4 human

Similar proteinsi

Entry informationi

Entry nameiMAFK_HUMAN
AccessioniPrimary (citable) accession number: O60675
Secondary accession number(s): A4D214
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: August 1, 1998
Last modified: March 28, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health