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Protein

DNA polymerase zeta catalytic subunit

Gene

REV3L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function.1 Publication

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster.By similarity

Kineticsi

kcat is 0.31 min(-1) for DNA synthesis by Pol-zeta4. kcat is 0.05 min(-1) for DNA synthesis by Pol-zeta2.1 Publication

Manual assertion based on experiment ini

  1. KM=5.71 µM for dATP (for Pol-zeta2)
  2. KM=1.17 µM for dATP (for Pol-zeta4)

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Metal bindingi3042ZincBy similarity1
    Metal bindingi3045ZincBy similarity1
    Metal bindingi3054ZincBy similarity1
    Metal bindingi3057ZincBy similarity1
    Metal bindingi3086Iron-sulfur (4Fe-4S)By similarity1
    Metal bindingi3089Iron-sulfur (4Fe-4S)By similarity1
    Metal bindingi3099Iron-sulfur (4Fe-4S)By similarity1
    Metal bindingi3104Iron-sulfur (4Fe-4S)By similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Zinc fingeri3042 – 3057CysA-typeAdd BLAST16

    GO - Molecular functioni

    GO - Biological processi

    • DNA-dependent DNA replication Source: ProtInc
    • error-prone translesion synthesis Source: GO_Central
    Complete GO annotation...

    Keywords - Molecular functioni

    DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    DNA damage, DNA repair, DNA replication

    Keywords - Ligandi

    4Fe-4S, DNA-binding, Iron, Iron-sulfur, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciZFISH:HS00262-MONOMER.
    ReactomeiR-HSA-110312. Translesion synthesis by REV1.
    R-HSA-5655862. Translesion synthesis by POLK.
    R-HSA-5656121. Translesion synthesis by POLI.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA polymerase zeta catalytic subunit (EC:2.7.7.7)
    Alternative name(s):
    Protein reversionless 3-like
    Short name:
    REV3-like
    Short name:
    hREV3
    Gene namesi
    Name:REV3L
    Synonyms:POLZ, REV3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:9968. REV3L.

    Subcellular locationi

    GO - Cellular componenti

    • nucleolus Source: Ensembl
    • nucleoplasm Source: Reactome
    • nucleus Source: GO_Central
    • zeta DNA polymerase complex Source: UniProtKB
    Complete GO annotation...

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Mutagenesisi2614D → N: Loss of DNA polymerase catalytic activity; when associated with N-2783. 1 Publication1
    Mutagenesisi2783D → N: Loss of DNA polymerase catalytic activity; when associated with N-2614. 1 Publication1

    Organism-specific databases

    DisGeNETi5980.
    OpenTargetsiENSG00000009413.
    PharmGKBiPA34337.

    Polymorphism and mutation databases

    BioMutaiREV3L.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000464681 – 3130DNA polymerase zeta catalytic subunitAdd BLAST3130

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei1030PhosphoserineCombined sources1
    Modified residuei1041PhosphothreonineCombined sources1
    Modified residuei1724PhosphoserineCombined sources1
    Modified residuei1967PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO60673.
    PaxDbiO60673.
    PeptideAtlasiO60673.
    PRIDEiO60673.

    PTM databases

    iPTMnetiO60673.
    PhosphoSitePlusiO60673.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.

    Gene expression databases

    BgeeiENSG00000009413.
    CleanExiHS_REV3L.
    ExpressionAtlasiO60673. baseline and differential.
    GenevisibleiO60673. HS.

    Organism-specific databases

    HPAiHPA064853.
    HPA069382.

    Interactioni

    Subunit structurei

    Heterodimer with MAD2L2. This dimer forms the minimal DNA polymerase zeta complex (Pol-zeta2), with REV3L bearing DNA polymerase catalytic activity, although its activity is very low in this context. Component of the tetrameric Pol-zeta complex (Pol-zeta4), which consists of REV3L, MAD2L2, POLD2 and POLD3; Pol-zeta4 is the fully active form of DNA polymerase zeta.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MAD2L2Q9UI955EBI-2871302,EBI-77889

    Protein-protein interaction databases

    BioGridi111912. 28 interactors.
    IntActiO60673. 8 interactors.
    MINTiMINT-2796978.
    STRINGi9606.ENSP00000351697.

    Structurei

    Secondary structure

    13130
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Beta strandi1877 – 1882Combined sources6
    Helixi1887 – 1893Combined sources7

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3ABDX-ray1.90X/Y1847-1898[»]
    3ABEX-ray2.60Z1847-1898[»]
    3VU7X-ray2.80Z1847-1898[»]
    4EXTX-ray1.90B1873-1895[»]
    4GK0X-ray2.70C/D1847-1898[»]
    4GK5X-ray3.21C/D1847-1898[»]
    ProteinModelPortaliO60673.
    SMRiO60673.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO60673.

    Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni1847 – 1898Mediates interaction with MAD2L21 PublicationAdd BLAST52

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Motifi3086 – 3104CysB motifAdd BLAST19

    Domaini

    Its C-terminal part could serve as the catalytic domain during nucleotide polymerization, while its N-terminal part could provide sites for protein-protein interactions with other factors during translesion DNA synthesis.
    The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.By similarity

    Sequence similaritiesi

    Belongs to the DNA polymerase type-B family.Curated
    Contains 1 CysA-type zinc finger.Curated

    Zinc finger

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Zinc fingeri3042 – 3057CysA-typeAdd BLAST16

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiKOG0968. Eukaryota.
    COG0417. LUCA.
    GeneTreeiENSGT00550000074640.
    HOGENOMiHOG000112263.
    HOVERGENiHBG000426.
    InParanoidiO60673.
    KOiK02350.
    OMAiFCSNPSD.
    OrthoDBiEOG091G01N0.
    PhylomeDBiO60673.
    TreeFamiTF101072.

    Family and domain databases

    Gene3Di3.30.420.10. 2 hits.
    3.90.1600.10. 2 hits.
    InterProiIPR006172. DNA-dir_DNA_pol_B.
    IPR017964. DNA-dir_DNA_pol_B_CS.
    IPR006133. DNA-dir_DNA_pol_B_exonuc.
    IPR006134. DNA-dir_DNA_pol_B_multi_dom.
    IPR023211. DNA_pol_palm_dom.
    IPR032757. DUF4683.
    IPR030559. PolZ_Rev3.
    IPR012337. RNaseH-like_dom.
    IPR025687. Znf-C4pol.
    [Graphical view]
    PANTHERiPTHR10322:SF5. PTHR10322:SF5. 4 hits.
    PfamiPF00136. DNA_pol_B. 1 hit.
    PF03104. DNA_pol_B_exo1. 2 hits.
    PF15735. DUF4683. 1 hit.
    PF14260. zf-C4pol. 1 hit.
    [Graphical view]
    PRINTSiPR00106. DNAPOLB.
    SMARTiSM00486. POLBc. 1 hit.
    [Graphical view]
    SUPFAMiSSF53098. SSF53098. 4 hits.
    PROSITEiPS00116. DNA_POLYMERASE_B. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: O60673-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MFSVRIVTAD YYMASPLQGL DTCQSPLTQA PVKKVPVVRV FGATPAGQKT
    60 70 80 90 100
    CLHLHGIFPY LYVPYDGYGQ QPESYLSQMA FSIDRALNVA LGNPSSTAQH
    110 120 130 140 150
    VFKVSLVSGM PFYGYHEKER HFMKIYLYNP TMVKRICELL QSGAIMNKFY
    160 170 180 190 200
    QPHEAHIPYL LQLFIDYNLY GMNLINLAAV KFRKARRKSN TLHATGSCKN
    210 220 230 240 250
    HLSGNSLADT LFRWEQDEIP SSLILEGVEP QSTCELEVDA VAADILNRLD
    260 270 280 290 300
    IEAQIGGNPG LQAIWEDEKQ RRRNRNETSQ MSQPESQDHR FVPATESEKK
    310 320 330 340 350
    FQKRLQEILK QNDFSVTLSG SVDYSDGSQE FSAELTLHSE VLSPEMLQCT
    360 370 380 390 400
    PANMVEVHKD KESSKGHTRH KVEEALINEE AILNLMENSQ TFQPLTQRLS
    410 420 430 440 450
    ESPVFMDSSP DEALVHLLAG LESDGYRGER NRMPSPCRSF GNNKYPQNSD
    460 470 480 490 500
    DEENEPQIEK EEMELSLVMS QRWDSNIEEH CAKKRSLCRN THRSSTEDDD
    510 520 530 540 550
    SSSGEEMEWS DNSLLLASLS IPQLDGTADE NSDNPLNNEN SRTHSSVIAT
    560 570 580 590 600
    SKLSVKPSIF HKDAATLEPS SSAKITFQCK HTSALSSHVL NKEDLIEDLS
    610 620 630 640 650
    QTNKNTEKGL DNSVTSFTNE STYSMKYPGS LSSTVHSENS HKENSKKEIL
    660 670 680 690 700
    PVSSCESSIF DYEEDIPSVT RQVPSRKYTN IRKIEKDSPF IHMHRHPNEN
    710 720 730 740 750
    TLGKNSFNFS DLNHSKNKVS SEGNEKGNST ALSSLFPSSF TENCELLSCS
    760 770 780 790 800
    GENRTMVHSL NSTADESGLN KLKIRYEEFQ EHKTEKPSLS QQAAHYMFFP
    810 820 830 840 850
    SVVLSNCLTR PQKLSPVTYK LQPGNKPSRL KLNKRKLAGH QETSTKSSET
    860 870 880 890 900
    GSTKDNFIQN NPCNSNPEKD NALASDLTKT TRGAFENKTP TDGFIDCHFG
    910 920 930 940 950
    DGTLETEQSF GLYGNKYTLR AKRKVNYETE DSESSFVTHN SKISLPHPME
    960 970 980 990 1000
    IGESLDGTLK SRKRRKMSKK LPPVIIKYII INRFRGRKNM LVKLGKIDSK
    1010 1020 1030 1040 1050
    EKQVILTEEK MELYKKLAPL KDFWPKVPDS PATKYPIYPL TPKKSHRRKS
    1060 1070 1080 1090 1100
    KHKSAKKKTG KQQRTNNENI KRTLSFRKKR SHAILSPPSP SYNAETEDCD
    1110 1120 1130 1140 1150
    LNYSDVMSKL GFLSERSTSP INSSPPRCWS PTDPRAEEIM AAAEKEAMLF
    1160 1170 1180 1190 1200
    KGPNVYKKTV NSRIGKTSRA RAQIKKSKAK LANPSIVTKK RNKRNQTNKL
    1210 1220 1230 1240 1250
    VDDGKKKPRA KQKTNEKGTS RKHTTLKDEK IKSQSGAEVK FVLKHQNVSE
    1260 1270 1280 1290 1300
    FASSSGGSQL LFKQKDMPLM GSAVDHPLSA SLPTGINAQQ KLSGCFSSFL
    1310 1320 1330 1340 1350
    ESKKSVDLQT FPSSRDDLHP SVVCNSIGPG VSKINVQRPH NQSAMFTLKE
    1360 1370 1380 1390 1400
    STLIQKNIFD LSNHLSQVAQ NTQISSGMSS KIEDNANNIQ RNYLSSIGKL
    1410 1420 1430 1440 1450
    SEYRNSLESK LDQAYTPNFL HCKDSQQQIV CIAEQSKHSE TCSPGNTASE
    1460 1470 1480 1490 1500
    ESQMPNNCFV TSLRSPIKQI AWEQKQRGFI LDMSNFKPER VKPRSLSEAI
    1510 1520 1530 1540 1550
    SQTKALSQCK NRNVSTPSAF GEGQSGLAVL KELLQKRQQK AQNANTTQDP
    1560 1570 1580 1590 1600
    LSNKHQPNKN ISGSLEHNKA NKRTRSVTSP RKPRTPRSTK QKEKIPKLLK
    1610 1620 1630 1640 1650
    VDSLNLQNSS QLDNSVSDDS PIFFSDPGFE SCYSLEDSLS PEHNYNFDIN
    1660 1670 1680 1690 1700
    TIGQTGFCSF YSGSQFVPAD QNLPQKFLSD AVQDLFPGQA IEKNEFLSHD
    1710 1720 1730 1740 1750
    NQKCDEDKHH TTDSASWIRS GTLSPEIFEK STIDSNENRR HNQWKNSFHP
    1760 1770 1780 1790 1800
    LTTRSNSIMD SFCVQQAEDC LSEKSRLNRS SVSKEVFLSL PQPNNSDWIQ
    1810 1820 1830 1840 1850
    GHTRKEMGQS LDSANTSFTA ILSSPDGELV DVACEDLELY VSRNNDMLTP
    1860 1870 1880 1890 1900
    TPDSSPRSTS SPSQSKNGSF TPRTANILKP LMSPPSREEI MATLLDHDLS
    1910 1920 1930 1940 1950
    ETIYQEPFCS NPSDVPEKPR EIGGRLLMVE TRLANDLAEF EGDFSLEGLR
    1960 1970 1980 1990 2000
    LWKTAFSAMT QNPRPGSPLR SGQGVVNKGS SNSPKMVEDK KIVIMPCKCA
    2010 2020 2030 2040 2050
    PSRQLVQVWL QAKEEYERSK KLPKTKPTGV VKSAENFSSS VNPDDKPVVP
    2060 2070 2080 2090 2100
    PKMDVSPCIL PTTAHTKEDV DNSQIALQAP TTGCSQTASE SQMLPPVASA
    2110 2120 2130 2140 2150
    SDPEKDEDDD DNYYISYSSP DSPVIPPWQQ PISPDSKALN GDDRPSSPVE
    2160 2170 2180 2190 2200
    ELPSLAFENF LKPIKDGIQK SPCSEPQEPL VISPINTRAR TGKCESLCFH
    2210 2220 2230 2240 2250
    STPIIQRKLL ERLPEAPGLS PLSTEPKTQK LSNKKGSNTD TLRRVLLTQA
    2260 2270 2280 2290 2300
    KNQFAAVNTP QKETSQIDGP SLNNTYGFKV SIQNLQEAKA LHEIQNLTLI
    2310 2320 2330 2340 2350
    SVELHARTRR DLEPDPEFDP ICALFYCISS DTPLPDTEKT ELTGVIVIDK
    2360 2370 2380 2390 2400
    DKTVFSQDIR YQTPLLIRSG ITGLEVTYAA DEKALFHEIA NIIKRYDPDI
    2410 2420 2430 2440 2450
    LLGYEIQMHS WGYLLQRAAA LSIDLCRMIS RVPDDKIENR FAAERDEYGS
    2460 2470 2480 2490 2500
    YTMSEINIVG RITLNLWRIM RNEVALTNYT FENVSFHVLH QRFPLFTFRV
    2510 2520 2530 2540 2550
    LSDWFDNKTD LYRWKMVDHY VSRVRGNLQM LEQLDLIGKT SEMARLFGIQ
    2560 2570 2580 2590 2600
    FLHVLTRGSQ YRVESMMLRI AKPMNYIPVT PSVQQRSQMR APQCVPLIME
    2610 2620 2630 2640 2650
    PESRFYSNSV LVLDFQSLYP SIVIAYNYCF STCLGHVENL GKYDEFKFGC
    2660 2670 2680 2690 2700
    TSLRVPPDLL YQVRHDITVS PNGVAFVKPS VRKGVLPRML EEILKTRFMV
    2710 2720 2730 2740 2750
    KQSMKAYKQD RALSRMLDAR QLGLKLIANV TFGYTSANFS GRMPCIEVGD
    2760 2770 2780 2790 2800
    SIVHKARETL ERAIKLVNDT KKWGARVVYG DTDSMFVLLK GATKEQSFKI
    2810 2820 2830 2840 2850
    GQEIAEAVTA TNPKPVKLKF EKVYLPCVLQ TKKRYVGYMY ETLDQKDPVF
    2860 2870 2880 2890 2900
    DAKGIETVRR DSCPAVSKIL ERSLKLLFET RDISLIKQYV QRQCMKLLEG
    2910 2920 2930 2940 2950
    KASIQDFIFA KEYRGSFSYK PGACVPALEL TRKMLTYDRR SEPQVGERVP
    2960 2970 2980 2990 3000
    YVIIYGTPGV PLIQLVRRPV EVLQDPTLRL NATYYITKQI LPPLARIFSL
    3010 3020 3030 3040 3050
    IGIDVFSWYH ELPRIHKATS SSRSEPEGRK GTISQYFTTL HCPVCDDLTQ
    3060 3070 3080 3090 3100
    HGICSKCRSQ PQHVAVILNQ EIRELERQQE QLVKICKNCT GCFDRHIPCV
    3110 3120 3130
    SLNCPVLFKL SRVNRELSKA PYLRQLLDQF
    Length:3,130
    Mass (Da):352,776
    Last modified:April 3, 2007 - v2
    Checksum:i4FBAA214639DF3C6
    GO
    Isoform 2 (identifier: O60673-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-78: Missing.

    Show »
    Length:3,052
    Mass (Da):344,154
    Checksum:iB6983F80F81AB4AF
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti237E → Q in AAC28460 (PubMed:9925914).Curated1
    Sequence conflicti237E → Q in AAB88486 (PubMed:10660610).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_008516231Q → H.2 PublicationsCorresponds to variant rs1053911dbSNPEnsembl.1
    Natural variantiVAR_008517389S → T.1
    Natural variantiVAR_022226397Q → P.1 PublicationCorresponds to variant rs3218579dbSNPEnsembl.1
    Natural variantiVAR_048883633S → G.Corresponds to variant rs3218598dbSNPEnsembl.1
    Natural variantiVAR_022227693M → T.1 PublicationCorresponds to variant rs3218593dbSNPEnsembl.1
    Natural variantiVAR_022228962R → Q.1 PublicationCorresponds to variant rs17539588dbSNPEnsembl.1
    Natural variantiVAR_0222291156Y → C.3 PublicationsCorresponds to variant rs458017dbSNPEnsembl.1
    Natural variantiVAR_0488841220S → L.Corresponds to variant rs3218600dbSNPEnsembl.1
    Natural variantiVAR_0222301224T → I.6 PublicationsCorresponds to variant rs462779dbSNPEnsembl.1
    Natural variantiVAR_0488851284T → P.Corresponds to variant rs3218578dbSNPEnsembl.1
    Natural variantiVAR_0222311302S → T.1 PublicationCorresponds to variant rs3218597dbSNPEnsembl.1
    Natural variantiVAR_0222321309Q → H.1 PublicationCorresponds to variant rs3218595dbSNPEnsembl.1
    Natural variantiVAR_0222331339P → T.1 PublicationCorresponds to variant rs17539616dbSNPEnsembl.1
    Natural variantiVAR_0222341469Q → P.1 PublicationCorresponds to variant rs3218572dbSNPEnsembl.1
    Natural variantiVAR_0085181540K → E.2 PublicationsCorresponds to variant rs1053913dbSNPEnsembl.1
    Natural variantiVAR_0222351576S → L.1 PublicationCorresponds to variant rs3218582dbSNPEnsembl.1
    Natural variantiVAR_0222361713D → N.1 PublicationCorresponds to variant rs3218585dbSNPEnsembl.1
    Natural variantiVAR_0222371724S → T.1 PublicationCorresponds to variant rs17539644dbSNPEnsembl.1
    Natural variantiVAR_0222381791P → S.1 PublicationCorresponds to variant rs17539651dbSNPEnsembl.1
    Natural variantiVAR_0222391812D → H.1 PublicationCorresponds to variant rs3218599dbSNPEnsembl.1
    Natural variantiVAR_0222401923G → R.1 PublicationCorresponds to variant rs3218604dbSNPEnsembl.1
    Natural variantiVAR_0222411970R → H.1 PublicationCorresponds to variant rs3218606dbSNPEnsembl.1
    Natural variantiVAR_0222422015E → V.1 PublicationCorresponds to variant rs17539692dbSNPEnsembl.1
    Natural variantiVAR_0222432075I → M.1 PublicationCorresponds to variant rs17510963dbSNPEnsembl.1
    Natural variantiVAR_0085192607S → T.1
    Natural variantiVAR_0222442762R → Q.1 PublicationCorresponds to variant rs3218592dbSNPEnsembl.1
    Natural variantiVAR_0161473064V → I.1 PublicationCorresponds to variant rs3204953dbSNPEnsembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0241211 – 78Missing in isoform 2. 1 PublicationAdd BLAST78

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF058701 mRNA. Translation: AAC24357.1.
    AF071798 mRNA. Translation: AAC24009.1.
    AF157476 mRNA. Translation: AAD40184.1.
    AF179428 mRNA. Translation: AAG09402.1.
    AF179429 mRNA. Translation: AAG09403.1.
    AF078695 mRNA. Translation: AAC28460.1.
    AY684169 Genomic DNA. Translation: AAT74627.1.
    AL080317, AL136310, AL512325 Genomic DNA. Translation: CAI19192.1.
    AL136310, AL080317, AL512325 Genomic DNA. Translation: CAI20509.1.
    AL512325, AL080317, AL136310 Genomic DNA. Translation: CAI20998.1.
    AF035537 mRNA. Translation: AAB88486.1.
    CCDSiCCDS5091.2. [O60673-1]
    CCDS69177.1. [O60673-2]
    RefSeqiNP_001273360.1. NM_001286431.1. [O60673-2]
    NP_001273361.1. NM_001286432.1. [O60673-2]
    NP_002903.3. NM_002912.4. [O60673-1]
    UniGeneiHs.232021.

    Genome annotation databases

    EnsembliENST00000358835; ENSP00000351697; ENSG00000009413. [O60673-1]
    ENST00000368802; ENSP00000357792; ENSG00000009413. [O60673-1]
    ENST00000368805; ENSP00000357795; ENSG00000009413. [O60673-1]
    ENST00000435970; ENSP00000402003; ENSG00000009413. [O60673-2]
    GeneIDi5980.
    KEGGihsa:5980.
    UCSCiuc003puy.6. human. [O60673-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF058701 mRNA. Translation: AAC24357.1.
    AF071798 mRNA. Translation: AAC24009.1.
    AF157476 mRNA. Translation: AAD40184.1.
    AF179428 mRNA. Translation: AAG09402.1.
    AF179429 mRNA. Translation: AAG09403.1.
    AF078695 mRNA. Translation: AAC28460.1.
    AY684169 Genomic DNA. Translation: AAT74627.1.
    AL080317, AL136310, AL512325 Genomic DNA. Translation: CAI19192.1.
    AL136310, AL080317, AL512325 Genomic DNA. Translation: CAI20509.1.
    AL512325, AL080317, AL136310 Genomic DNA. Translation: CAI20998.1.
    AF035537 mRNA. Translation: AAB88486.1.
    CCDSiCCDS5091.2. [O60673-1]
    CCDS69177.1. [O60673-2]
    RefSeqiNP_001273360.1. NM_001286431.1. [O60673-2]
    NP_001273361.1. NM_001286432.1. [O60673-2]
    NP_002903.3. NM_002912.4. [O60673-1]
    UniGeneiHs.232021.

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3ABDX-ray1.90X/Y1847-1898[»]
    3ABEX-ray2.60Z1847-1898[»]
    3VU7X-ray2.80Z1847-1898[»]
    4EXTX-ray1.90B1873-1895[»]
    4GK0X-ray2.70C/D1847-1898[»]
    4GK5X-ray3.21C/D1847-1898[»]
    ProteinModelPortaliO60673.
    SMRiO60673.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi111912. 28 interactors.
    IntActiO60673. 8 interactors.
    MINTiMINT-2796978.
    STRINGi9606.ENSP00000351697.

    PTM databases

    iPTMnetiO60673.
    PhosphoSitePlusiO60673.

    Polymorphism and mutation databases

    BioMutaiREV3L.

    Proteomic databases

    MaxQBiO60673.
    PaxDbiO60673.
    PeptideAtlasiO60673.
    PRIDEiO60673.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000358835; ENSP00000351697; ENSG00000009413. [O60673-1]
    ENST00000368802; ENSP00000357792; ENSG00000009413. [O60673-1]
    ENST00000368805; ENSP00000357795; ENSG00000009413. [O60673-1]
    ENST00000435970; ENSP00000402003; ENSG00000009413. [O60673-2]
    GeneIDi5980.
    KEGGihsa:5980.
    UCSCiuc003puy.6. human. [O60673-1]

    Organism-specific databases

    CTDi5980.
    DisGeNETi5980.
    GeneCardsiREV3L.
    H-InvDBHIX0017582.
    HGNCiHGNC:9968. REV3L.
    HPAiHPA064853.
    HPA069382.
    MIMi602776. gene.
    neXtProtiNX_O60673.
    OpenTargetsiENSG00000009413.
    PharmGKBiPA34337.
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG0968. Eukaryota.
    COG0417. LUCA.
    GeneTreeiENSGT00550000074640.
    HOGENOMiHOG000112263.
    HOVERGENiHBG000426.
    InParanoidiO60673.
    KOiK02350.
    OMAiFCSNPSD.
    OrthoDBiEOG091G01N0.
    PhylomeDBiO60673.
    TreeFamiTF101072.

    Enzyme and pathway databases

    BioCyciZFISH:HS00262-MONOMER.
    ReactomeiR-HSA-110312. Translesion synthesis by REV1.
    R-HSA-5655862. Translesion synthesis by POLK.
    R-HSA-5656121. Translesion synthesis by POLI.

    Miscellaneous databases

    ChiTaRSiREV3L. human.
    EvolutionaryTraceiO60673.
    GeneWikiiREV3L.
    GenomeRNAii5980.
    PROiO60673.
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000009413.
    CleanExiHS_REV3L.
    ExpressionAtlasiO60673. baseline and differential.
    GenevisibleiO60673. HS.

    Family and domain databases

    Gene3Di3.30.420.10. 2 hits.
    3.90.1600.10. 2 hits.
    InterProiIPR006172. DNA-dir_DNA_pol_B.
    IPR017964. DNA-dir_DNA_pol_B_CS.
    IPR006133. DNA-dir_DNA_pol_B_exonuc.
    IPR006134. DNA-dir_DNA_pol_B_multi_dom.
    IPR023211. DNA_pol_palm_dom.
    IPR032757. DUF4683.
    IPR030559. PolZ_Rev3.
    IPR012337. RNaseH-like_dom.
    IPR025687. Znf-C4pol.
    [Graphical view]
    PANTHERiPTHR10322:SF5. PTHR10322:SF5. 4 hits.
    PfamiPF00136. DNA_pol_B. 1 hit.
    PF03104. DNA_pol_B_exo1. 2 hits.
    PF15735. DUF4683. 1 hit.
    PF14260. zf-C4pol. 1 hit.
    [Graphical view]
    PRINTSiPR00106. DNAPOLB.
    SMARTiSM00486. POLBc. 1 hit.
    [Graphical view]
    SUPFAMiSSF53098. SSF53098. 4 hits.
    PROSITEiPS00116. DNA_POLYMERASE_B. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Entry informationi

    Entry nameiREV3L_HUMAN
    AccessioniPrimary (citable) accession number: O60673
    Secondary accession number(s): O43214, Q5TC33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: April 3, 2007
    Last modified: November 30, 2016
    This is version 155 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.