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O60669

- MOT2_HUMAN

UniProt

O60669 - MOT2_HUMAN

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Protein

Monocarboxylate transporter 2

Gene

SLC16A7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter.1 Publication

GO - Molecular functioni

  1. lactate transmembrane transporter activity Source: UniProtKB
  2. pyruvate secondary active transmembrane transporter activity Source: ProtInc
  3. pyruvate transmembrane transporter activity Source: UniProtKB
  4. secondary active monocarboxylate transmembrane transporter activity Source: InterPro
  5. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. lactate transmembrane transport Source: UniProtKB
  2. pyruvate transmembrane transport Source: UniProtKB
  3. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_20515. Proton-coupled monocarboxylate transport.
SABIO-RKO60669.

Protein family/group databases

TCDBi2.A.1.13.5. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 2
Short name:
MCT 2
Alternative name(s):
Solute carrier family 16 member 7
Gene namesi
Name:SLC16A7
Synonyms:MCT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:10928. SLC16A7.

Subcellular locationi

Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35819.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Monocarboxylate transporter 2PRO_0000211385Add
BLAST

Proteomic databases

MaxQBiO60669.
PaxDbiO60669.
PRIDEiO60669.

PTM databases

PhosphoSiteiO60669.

Expressioni

Tissue specificityi

Detected in heart and in blood lymphocytes and monocytes (at protein level). High expression in testis, moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain and Leukocyte. Restricted expression in normal tissues, but widely expressed in cancer cells.1 Publication

Gene expression databases

BgeeiO60669.
CleanExiHS_SLC16A7.
ExpressionAtlasiO60669. baseline and differential.
GenevestigatoriO60669.

Organism-specific databases

HPAiHPA005911.

Interactioni

Subunit structurei

Interacts with GRID2IP.By similarity

Protein-protein interaction databases

BioGridi114629. 3 interactions.
IntActiO60669. 1 interaction.
STRINGi9606.ENSP00000261187.

Structurei

3D structure databases

ProteinModelPortaliO60669.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini37 – 5923ExtracellularSequence AnalysisAdd
BLAST
Topological domaini81 – 899CytoplasmicSequence Analysis
Topological domaini111 – 1155ExtracellularSequence Analysis
Topological domaini137 – 14812CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini170 – 1734ExtracellularSequence Analysis
Topological domaini195 – 24652CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini268 – 28215ExtracellularSequence AnalysisAdd
BLAST
Topological domaini304 – 3129CytoplasmicSequence Analysis
Topological domaini334 – 3385ExtracellularSequence Analysis
Topological domaini360 – 37314CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini395 – 40612ExtracellularSequence AnalysisAdd
BLAST
Topological domaini428 – 47851CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence AnalysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence AnalysisAdd
BLAST
Transmembranei90 – 11021HelicalSequence AnalysisAdd
BLAST
Transmembranei116 – 13621HelicalSequence AnalysisAdd
BLAST
Transmembranei149 – 16921HelicalSequence AnalysisAdd
BLAST
Transmembranei174 – 19421HelicalSequence AnalysisAdd
BLAST
Transmembranei247 – 26721HelicalSequence AnalysisAdd
BLAST
Transmembranei283 – 30321HelicalSequence AnalysisAdd
BLAST
Transmembranei313 – 33321HelicalSequence AnalysisAdd
BLAST
Transmembranei339 – 35921HelicalSequence AnalysisAdd
BLAST
Transmembranei374 – 39421HelicalSequence AnalysisAdd
BLAST
Transmembranei407 – 42721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiO60669.
KOiK08184.
OMAiCCLGMVT.
OrthoDBiEOG7W9RTN.
PhylomeDBiO60669.
TreeFamiTF313792.

Family and domain databases

InterProiIPR027178. MCT2.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004743. Monocarb_transpt.
[Graphical view]
PANTHERiPTHR11360:SF25. PTHR11360:SF25. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60669-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPPMPSAPPV HPPPDGGWGW IVVGAAFISI GFSYAFPKAV TVFFKEIQQI
60 70 80 90 100
FHTTYSEIAW ISSIMLAVMY AGGPVSSVLV NKYGSRPVVI AGGLLCCLGM
110 120 130 140 150
VLASFSSSVV QLYLTMGFIT GLGLAFNLQP ALTIIGKYFY RKRPMANGLA
160 170 180 190 200
MAGSPVFLSS LAPFNQYLFN TFGWKGSFLI LGSLLLNACV AGSLMRPLGP
210 220 230 240 250
NQTTSKSKNK TGKTEDDSSP KKIKTKKSTW EKVNKYLDFS LFKHRGFLIY
260 270 280 290 300
LSGNVIMFLG FFAPIIFLAP YAKDQGIDEY SAAFLLSVMA FVDMFARPSV
310 320 330 340 350
GLIANSKYIR PRIQYFFSFA IMFNGVCHLL CPLAQDYTSL VLYAVFFGLG
360 370 380 390 400
FGSVSSVLFE TLMDLVGAPR FSSAVGLVTI VECGPVLLGP PLAGKLVDLT
410 420 430 440 450
GEYKYMYMSC GAIVVAASVW LLIGNAINYR LLAKERKEEN ARQKTRESEP
460 470
LSKSKHSEDV NVKVSNAQSV TSERETNI
Length:478
Mass (Da):52,200
Last modified:November 30, 2010 - v2
Checksum:iE508D650E8D7DE98
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261A → T in AAC70919. 1 PublicationCurated
Sequence conflicti154 – 1541S → N in AAC70919. 1 PublicationCurated
Sequence conflicti268 – 2681L → P in AAC70919. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti445 – 4451T → S.1 Publication
Corresponds to variant rs3763980 [ dbSNP | Ensembl ].
VAR_031660

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF049608 mRNA. Translation: AAC70919.1.
AF058056 mRNA. Translation: AAC13721.1.
AK313345 mRNA. Translation: BAG36148.1.
AC079905 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97096.1.
BC030693 mRNA. Translation: AAH30693.1.
CCDSiCCDS8961.1.
RefSeqiNP_001257551.1. NM_001270622.1.
NP_001257552.1. NM_001270623.1.
NP_004722.2. NM_004731.4.
XP_005269288.1. XM_005269231.2.
XP_006719756.1. XM_006719693.1.
UniGeneiHs.439643.
Hs.88156.

Genome annotation databases

EnsembliENST00000261187; ENSP00000261187; ENSG00000118596.
ENST00000547379; ENSP00000448071; ENSG00000118596.
ENST00000552024; ENSP00000448742; ENSG00000118596.
ENST00000552432; ENSP00000449547; ENSG00000118596.
GeneIDi9194.
KEGGihsa:9194.
UCSCiuc001sqs.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF049608 mRNA. Translation: AAC70919.1 .
AF058056 mRNA. Translation: AAC13721.1 .
AK313345 mRNA. Translation: BAG36148.1 .
AC079905 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97096.1 .
BC030693 mRNA. Translation: AAH30693.1 .
CCDSi CCDS8961.1.
RefSeqi NP_001257551.1. NM_001270622.1.
NP_001257552.1. NM_001270623.1.
NP_004722.2. NM_004731.4.
XP_005269288.1. XM_005269231.2.
XP_006719756.1. XM_006719693.1.
UniGenei Hs.439643.
Hs.88156.

3D structure databases

ProteinModelPortali O60669.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114629. 3 interactions.
IntActi O60669. 1 interaction.
STRINGi 9606.ENSP00000261187.

Chemistry

ChEMBLi CHEMBL2073704.
DrugBanki DB01440. Gamma Hydroxybutyric Acid.
DB04552. Niflumic Acid.
DB01032. Probenecid.
DB00119. Pyruvic acid.

Protein family/group databases

TCDBi 2.A.1.13.5. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitei O60669.

Proteomic databases

MaxQBi O60669.
PaxDbi O60669.
PRIDEi O60669.

Protocols and materials databases

DNASUi 9194.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261187 ; ENSP00000261187 ; ENSG00000118596 .
ENST00000547379 ; ENSP00000448071 ; ENSG00000118596 .
ENST00000552024 ; ENSP00000448742 ; ENSG00000118596 .
ENST00000552432 ; ENSP00000449547 ; ENSG00000118596 .
GeneIDi 9194.
KEGGi hsa:9194.
UCSCi uc001sqs.4. human.

Organism-specific databases

CTDi 9194.
GeneCardsi GC12P059989.
H-InvDB HIX0010769.
HGNCi HGNC:10928. SLC16A7.
HPAi HPA005911.
MIMi 603654. gene.
neXtProti NX_O60669.
PharmGKBi PA35819.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00760000118926.
HOGENOMi HOG000280688.
HOVERGENi HBG006384.
InParanoidi O60669.
KOi K08184.
OMAi CCLGMVT.
OrthoDBi EOG7W9RTN.
PhylomeDBi O60669.
TreeFami TF313792.

Enzyme and pathway databases

Reactomei REACT_20515. Proton-coupled monocarboxylate transport.
SABIO-RK O60669.

Miscellaneous databases

GenomeRNAii 9194.
NextBioi 34471.
PROi O60669.
SOURCEi Search...

Gene expression databases

Bgeei O60669.
CleanExi HS_SLC16A7.
ExpressionAtlasi O60669. baseline and differential.
Genevestigatori O60669.

Family and domain databases

InterProi IPR027178. MCT2.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004743. Monocarb_transpt.
[Graphical view ]
PANTHERi PTHR11360:SF25. PTHR11360:SF25. 1 hit.
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
TIGRFAMsi TIGR00892. 2A0113. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter."
    Lin R.-Y., Vera J.C., Chaganti R.S.K., Golde D.W.
    J. Biol. Chem. 273:28959-28965(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
    Tissue: Liver.
  2. "Cloning of human monocarboxylate transporter 2 (hMCT2)."
    Dao L., Landschulz W.H., Landschulz K.T.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-445.
    Tissue: Liver.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  7. "Presence and localization of three lactic acid transporters (MCT1, -2, and -4) in separated human granulocytes, lymphocytes, and monocytes."
    Merezhinskaya N., Ogunwuyi S.A., Mullick F.G., Fishbein W.N.
    J. Histochem. Cytochem. 52:1483-1493(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiMOT2_HUMAN
AccessioniPrimary (citable) accession number: O60669
Secondary accession number(s): Q8NEM3, Q9UPB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 30, 2010
Last modified: October 29, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3