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Protein

Fas apoptotic inhibitory molecule 3

Gene

FCMR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.1 Publication

GO - Biological processi

  • cellular defense response Source: ProtInc
  • immune system process Source: UniProtKB-KW
  • negative regulation of apoptotic process Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Fas apoptotic inhibitory molecule 3Curated
Alternative name(s):
IgM Fc fragment receptorImported
Regulator of Fas-induced apoptosis Toso1 Publication
Gene namesi
Name:FCMRImported
Synonyms:FAIM3, TOSO
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14315. FCMR.

Subcellular locationi

Isoform 1 :
Isoform 3 :

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 251234ExtracellularSequence analysisAdd
BLAST
Transmembranei252 – 27221HelicalSequence analysisAdd
BLAST
Topological domaini273 – 390118CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671899.

Polymorphism and mutation databases

BioMutaiFAIM3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 390373Fas apoptotic inhibitory molecule 3PRO_0000284421Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 104By similarity
Modified residuei92 – 921PhosphothreonineBy similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiO60667.
PRIDEiO60667.

PTM databases

iPTMnetiO60667.
PhosphoSiteiO60667.

Expressioni

Tissue specificityi

Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11;19 and Reh. No expression detected in nonhematopoietic cell lines including Hep-G2, HEK293 and HeLa. Detected at high levels in chronic lymphocytic leukemia cells.2 Publications

Inductioni

By T-cell activation.1 Publication

Gene expression databases

BgeeiO60667.
CleanExiHS_FAIM3.
ExpressionAtlasiO60667. baseline and differential.
GenevisibleiO60667. HS.

Organism-specific databases

HPAiHPA003910.

Interactioni

Protein-protein interaction databases

BioGridi114648. 3 interactions.
IntActiO60667. 1 interaction.
STRINGi9606.ENSP00000356058.

Structurei

3D structure databases

ProteinModelPortaliO60667.
SMRiO60667. Positions 30-107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 10573Ig-likeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi274 – 32350Arg-richAdd
BLAST

Domaini

The Ig-like domain is required for the anti-apoptotic ability.

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ2J. Eukaryota.
ENOG41113GQ. LUCA.
GeneTreeiENSGT00530000063436.
HOGENOMiHOG000013142.
HOVERGENiHBG107910.
InParanoidiO60667.
OMAiTIECPLP.
OrthoDBiEOG73FQNQ.
PhylomeDBiO60667.
TreeFamiTF338713.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60667-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDFWLWPLYF LPVSGALRIL PEVKVEGELG GSVTIKCPLP EMHVRIYLCR
60 70 80 90 100
EMAGSGTCGT VVSTTNFIKA EYKGRVTLKQ YPRKNLFLVE VTQLTESDSG
110 120 130 140 150
VYACGAGMNT DRGKTQKVTL NVHSEYEPSW EEQPMPETPK WFHLPYLFQM
160 170 180 190 200
PAYASSSKFV TRVTTPAQRG KVPPVHHSSP TTQITHRPRV SRASSVAGDK
210 220 230 240 250
PRTFLPSTTA SKISALEGLL KPQTPSYNHH TRLHRQRALD YGSQSGREGQ
260 270 280 290 300
GFHILIPTIL GLFLLALLGL VVKRAVERRK ALSRRARRLA VRMRALESSQ
310 320 330 340 350
RPRGSPRPRS QNNIYSACPR RARGADAAGT GEAPVPGPGA PLPPAPLQVS
360 370 380 390
ESPWLHAPSL KTSCEYVSLY HQPAAMMEDS DSDDYINVPA
Length:390
Mass (Da):43,146
Last modified:August 1, 1998 - v1
Checksum:iFE91D217EECA99C6
GO
Isoform 2 (identifier: O60667-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     13-124: Missing.

Note: No experimental confirmation available.
Show »
Length:278
Mass (Da):31,029
Checksum:i653219845F8B508A
GO
Isoform 3 (identifier: O60667-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-245: RALDYGSQS → SPLQAGPPT
     249-390: GQGFHILIPT...DSDDYINVPA → DARPGELPEA...AVAPRPAAGV

Show »
Length:306
Mass (Da):33,828
Checksum:iC24B05122E5DD4C8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei13 – 124112Missing in isoform 2. 1 PublicationVSP_042947Add
BLAST
Alternative sequencei237 – 2459RALDYGSQS → SPLQAGPPT in isoform 3. 1 PublicationVSP_045188
Alternative sequencei249 – 390142GQGFH…INVPA → DARPGELPEAPRVAATALPK QHLQRLPAARSWSGRCRHRG GPRSRPRSAVAPRPAAGV in isoform 3. 1 PublicationVSP_045189Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057557 mRNA. Translation: AAC18830.1.
HM480394 mRNA. Translation: ADK11426.1.
BT006797 mRNA. Translation: AAP35443.1.
AK292007 mRNA. Translation: BAF84696.1.
AK301187 mRNA. Translation: BAH13426.1.
AK316336 mRNA. Translation: BAH14707.1.
AC098935 Genomic DNA. No translation available.
CH471100 Genomic DNA. Translation: EAW93517.1.
BC006401 mRNA. Translation: AAH06401.1.
CCDSiCCDS1473.1. [O60667-1]
CCDS44304.1. [O60667-2]
CCDS53467.1. [O60667-3]
RefSeqiNP_001135945.1. NM_001142473.1. [O60667-2]
NP_001180267.1. NM_001193338.1. [O60667-3]
NP_005440.1. NM_005449.4. [O60667-1]
UniGeneiHs.58831.
Hs.744273.

Genome annotation databases

EnsembliENST00000367091; ENSP00000356058; ENSG00000162894. [O60667-1]
ENST00000442471; ENSP00000404136; ENSG00000162894. [O60667-2]
ENST00000628511; ENSP00000485739; ENSG00000162894. [O60667-3]
GeneIDi9214.
KEGGihsa:9214.
UCSCiuc001hey.4. human. [O60667-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057557 mRNA. Translation: AAC18830.1.
HM480394 mRNA. Translation: ADK11426.1.
BT006797 mRNA. Translation: AAP35443.1.
AK292007 mRNA. Translation: BAF84696.1.
AK301187 mRNA. Translation: BAH13426.1.
AK316336 mRNA. Translation: BAH14707.1.
AC098935 Genomic DNA. No translation available.
CH471100 Genomic DNA. Translation: EAW93517.1.
BC006401 mRNA. Translation: AAH06401.1.
CCDSiCCDS1473.1. [O60667-1]
CCDS44304.1. [O60667-2]
CCDS53467.1. [O60667-3]
RefSeqiNP_001135945.1. NM_001142473.1. [O60667-2]
NP_001180267.1. NM_001193338.1. [O60667-3]
NP_005440.1. NM_005449.4. [O60667-1]
UniGeneiHs.58831.
Hs.744273.

3D structure databases

ProteinModelPortaliO60667.
SMRiO60667. Positions 30-107.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114648. 3 interactions.
IntActiO60667. 1 interaction.
STRINGi9606.ENSP00000356058.

PTM databases

iPTMnetiO60667.
PhosphoSiteiO60667.

Polymorphism and mutation databases

BioMutaiFAIM3.

Proteomic databases

PaxDbiO60667.
PRIDEiO60667.

Protocols and materials databases

DNASUi9214.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367091; ENSP00000356058; ENSG00000162894. [O60667-1]
ENST00000442471; ENSP00000404136; ENSG00000162894. [O60667-2]
ENST00000628511; ENSP00000485739; ENSG00000162894. [O60667-3]
GeneIDi9214.
KEGGihsa:9214.
UCSCiuc001hey.4. human. [O60667-1]

Organism-specific databases

CTDi9214.
GeneCardsiFAIM3.
HGNCiHGNC:14315. FCMR.
HPAiHPA003910.
MIMi606015. gene.
neXtProtiNX_O60667.
PharmGKBiPA142671899.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ2J. Eukaryota.
ENOG41113GQ. LUCA.
GeneTreeiENSGT00530000063436.
HOGENOMiHOG000013142.
HOVERGENiHBG107910.
InParanoidiO60667.
OMAiTIECPLP.
OrthoDBiEOG73FQNQ.
PhylomeDBiO60667.
TreeFamiTF338713.

Miscellaneous databases

ChiTaRSiFAIM3. human.
GenomeRNAii9214.
PROiO60667.
SOURCEiSearch...

Gene expression databases

BgeeiO60667.
CleanExiHS_FAIM3.
ExpressionAtlasiO60667. baseline and differential.
GenevisibleiO60667. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells."
    Hitoshi Y., Lorens J., Kitada S., Fisher J., LaBarge M., Ring H.Z., Francke U., Reed J.C., Kinoshita S., Nolan G.P.
    Immunity 8:461-471(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, INDUCTION.
  2. "Enhanced levels of both the membrane-bound and soluble forms of IgM Fc receptor (Fc?R) in patients with chronic lymphocytic leukemia."
    Li F.J., Kubagawa Y., McCollum M.K., Wilson L., Motohashi T., Bertoli L.F., Barton J.C., Barnes S., Davis R.S., Kubagawa H.
    Blood 118:4902-4909(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Spleen.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: B-cell.

Entry informationi

Entry nameiFAIM3_HUMAN
AccessioniPrimary (citable) accession number: O60667
Secondary accession number(s): A8K7J2, B7Z6Z0, D9MWM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: August 1, 1998
Last modified: June 8, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

'Toso' is a Japanese liquor drunk on New Year's day to celebrate long life and eternal youth.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.