O60667 (FAIM3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fas apoptotic inhibitory molecule 3

Alternative name(s):
Regulator of Fas-induced apoptosis Toso

Gene names

Name:	FAIM3
Synonyms:	TOSO

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. Ref.1
Subcellular location	Membrane; Single-pass membrane protein Potential.
Tissue specificity	Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat cells, CemT4 cells, MolT-4 cells, HB11.19 cells, and Reh cells. No expression detected in nonhematopoietic cell lines, including HepG2 cells, 293 cells and Hela cells. Ref.1
Induction	By T-cell activation. Ref.1
Domain	The Ig-like domain is required for the anti-apoptotic ability.
Miscellaneous	'Toso' is a Japanese liquor drunk on New Year's day to celebrate long life and eternal youth.
Sequence similarities	Contains 1 Ig-like (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Immunity
Cellular component	Membrane
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	anti-apoptosis Traceable author statement. Source: ProtInc cellular defense response Traceable author statement. Source: ProtInc
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 390	373	Fas apoptotic inhibitory molecule 3		PRO_0000284421
Regions
	Topological domain	18 – 251	234	Extracellular Potential
	Transmembrane	252 – 272	21	Helical; Potential
	Topological domain	273 – 390	118	Cytoplasmic Potential
	Domain	33 – 105	73	Ig-like
	Compositional bias	274 – 323	50	Arg-rich
Amino acid modifications
	Disulfide bond	37 ↔ 104		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O60667 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: FE91D217EECA99C6	FASTA	390	43,146
	10 20 30 40 50 60 MDFWLWPLYF LPVSGALRIL PEVKVEGELG GSVTIKCPLP EMHVRIYLCR EMAGSGTCGT 70 80 90 100 110 120 VVSTTNFIKA EYKGRVTLKQ YPRKNLFLVE VTQLTESDSG VYACGAGMNT DRGKTQKVTL 130 140 150 160 170 180 NVHSEYEPSW EEQPMPETPK WFHLPYLFQM PAYASSSKFV TRVTTPAQRG KVPPVHHSSP 190 200 210 220 230 240 TTQITHRPRV SRASSVAGDK PRTFLPSTTA SKISALEGLL KPQTPSYNHH TRLHRQRALD 250 260 270 280 290 300 YGSQSGREGQ GFHILIPTIL GLFLLALLGL VVKRAVERRK ALSRRARRLA VRMRALESSQ 310 320 330 340 350 360 RPRGSPRPRS QNNIYSACPR RARGADAAGT GEAPVPGPGA PLPPAPLQVS ESPWLHAPSL 370 380 390 KTSCEYVSLY HQPAAMMEDS DSDDYINVPA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells." Hitoshi Y., Lorens J., Kitada S., Fisher J., LaBarge M., Ring H.Z., Francke U., Reed J.C., Kinoshita S., Nolan G.P. Immunity 8:461-471(1998) [PubMed: 9586636] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION.
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: B-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF057557 mRNA. Translation: AAC18830.1. BT006797 mRNA. Translation: AAP35443.1. AK292007 mRNA. Translation: BAF84696.1. CH471100 Genomic DNA. Translation: EAW93517.1. BC006401 mRNA. Translation: AAH06401.1.
IPI	IPI00023119.
RefSeq	NP_001135945.1. NM_001142473.1. NP_001180267.1. NM_001193338.1. NP_005440.1. NM_005449.4.
UniGene	Hs.58831. Hs.728324.
3D structure databases
HSSP	HSSP built from PDB template 1XED based on UniProtKB P01833.
ProteinModelPortal	O60667.
SMR	O60667. Positions 20-124.
ModBase	Search...
Protein-protein interaction databases
IntAct	O60667. 1 interaction.
STRING	O60667.
PTM databases
PhosphoSite	O60667.
Proteomic databases
PRIDE	O60667.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000367091; ENSP00000356058; ENSG00000162894. ENST00000420007; ENSP00000403356; ENSG00000162894.
GeneID	9214.
KEGG	hsa:9214.
NMPDR	fig|9606.3.peg.2979.
UCSC	uc001hey.1. human.
Organism-specific databases
CTD	9214.
GeneCards	GC01M207076.
H-InvDB	HIX0001533.
HGNC	HGNC:14315. FAIM3.
HPA	HPA003910.
MIM	606015. gene.
neXtProt	NX_O60667.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG15234.
GeneTree	ENSGT00530000063436.
HOGENOM	HBG125830.
HOVERGEN	HBG107910.
InParanoid	O60667.
OMA	VYACGAG.
OrthoDB	EOG4SJ5FJ.
PhylomeDB	O60667.
Enzyme and pathway databases
Pathway_Interaction_DB	faspathway. FAS signaling pathway (CD95).
Gene expression databases
ArrayExpress	O60667.
Bgee	O60667.
CleanEx	HS_FAIM3.
Genevestigator	O60667.
Family and domain databases
InterPro	IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013151. Immunoglobulin. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
Pfam	PF00047. ig. 1 hit. [Graphical view]
SMART	SM00409. IG. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	34543.
SOURCE	Search...

Entry information

Entry name

FAIM3_HUMAN

Accession

Primary (citable) accession number: O60667
Secondary accession number(s): A8K7J2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.