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Protein

Fas apoptotic inhibitory molecule 3

Gene

FCMR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.1 Publication

GO - Biological processi

  • cellular defense response Source: ProtInc
  • immune system process Source: UniProtKB-KW
  • negative regulation of apoptotic process Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162894-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fas apoptotic inhibitory molecule 3Curated
Alternative name(s):
IgM Fc fragment receptorImported
Regulator of Fas-induced apoptosis Toso1 Publication
Gene namesi
Name:FCMRImported
Synonyms:FAIM3, TOSO
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14315. FCMR.

Subcellular locationi

Isoform 1 :
Isoform 3 :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 251ExtracellularSequence analysisAdd BLAST234
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Topological domaini273 – 390CytoplasmicSequence analysisAdd BLAST118

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi9214.
OpenTargetsiENSG00000162894.
PharmGKBiPA142671899.

Polymorphism and mutation databases

BioMutaiFAIM3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000028442118 – 390Fas apoptotic inhibitory molecule 3Add BLAST373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 104By similarity
Modified residuei92PhosphothreonineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiO60667.
PeptideAtlasiO60667.
PRIDEiO60667.

PTM databases

iPTMnetiO60667.
PhosphoSitePlusiO60667.

Expressioni

Tissue specificityi

Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11;19 and Reh. No expression detected in nonhematopoietic cell lines including Hep-G2, HEK293 and HeLa. Detected at high levels in chronic lymphocytic leukemia cells.2 Publications

Inductioni

By T-cell activation.1 Publication

Gene expression databases

BgeeiENSG00000162894.
CleanExiHS_FAIM3.
ExpressionAtlasiO60667. baseline and differential.
GenevisibleiO60667. HS.

Organism-specific databases

HPAiHPA003910.

Interactioni

Protein-protein interaction databases

BioGridi114648. 3 interactors.
IntActiO60667. 1 interactor.
STRINGi9606.ENSP00000356058.

Structurei

3D structure databases

ProteinModelPortaliO60667.
SMRiO60667.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 105Ig-likeAdd BLAST73

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi274 – 323Arg-richAdd BLAST50

Domaini

The Ig-like domain is required for the anti-apoptotic ability.

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ2J. Eukaryota.
ENOG41113GQ. LUCA.
GeneTreeiENSGT00530000063436.
HOGENOMiHOG000013142.
HOVERGENiHBG107910.
InParanoidiO60667.
OMAiTIECPLP.
OrthoDBiEOG091G0K4T.
PhylomeDBiO60667.
TreeFamiTF338713.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60667-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDFWLWPLYF LPVSGALRIL PEVKVEGELG GSVTIKCPLP EMHVRIYLCR
60 70 80 90 100
EMAGSGTCGT VVSTTNFIKA EYKGRVTLKQ YPRKNLFLVE VTQLTESDSG
110 120 130 140 150
VYACGAGMNT DRGKTQKVTL NVHSEYEPSW EEQPMPETPK WFHLPYLFQM
160 170 180 190 200
PAYASSSKFV TRVTTPAQRG KVPPVHHSSP TTQITHRPRV SRASSVAGDK
210 220 230 240 250
PRTFLPSTTA SKISALEGLL KPQTPSYNHH TRLHRQRALD YGSQSGREGQ
260 270 280 290 300
GFHILIPTIL GLFLLALLGL VVKRAVERRK ALSRRARRLA VRMRALESSQ
310 320 330 340 350
RPRGSPRPRS QNNIYSACPR RARGADAAGT GEAPVPGPGA PLPPAPLQVS
360 370 380 390
ESPWLHAPSL KTSCEYVSLY HQPAAMMEDS DSDDYINVPA
Length:390
Mass (Da):43,146
Last modified:August 1, 1998 - v1
Checksum:iFE91D217EECA99C6
GO
Isoform 2 (identifier: O60667-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     13-124: Missing.

Note: No experimental confirmation available.
Show »
Length:278
Mass (Da):31,029
Checksum:i653219845F8B508A
GO
Isoform 3 (identifier: O60667-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-245: RALDYGSQS → SPLQAGPPT
     249-390: GQGFHILIPT...DSDDYINVPA → DARPGELPEA...AVAPRPAAGV

Show »
Length:306
Mass (Da):33,828
Checksum:iC24B05122E5DD4C8
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04294713 – 124Missing in isoform 2. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_045188237 – 245RALDYGSQS → SPLQAGPPT in isoform 3. 1 Publication9
Alternative sequenceiVSP_045189249 – 390GQGFH…INVPA → DARPGELPEAPRVAATALPK QHLQRLPAARSWSGRCRHRG GPRSRPRSAVAPRPAAGV in isoform 3. 1 PublicationAdd BLAST142

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057557 mRNA. Translation: AAC18830.1.
HM480394 mRNA. Translation: ADK11426.1.
BT006797 mRNA. Translation: AAP35443.1.
AK292007 mRNA. Translation: BAF84696.1.
AK301187 mRNA. Translation: BAH13426.1.
AK316336 mRNA. Translation: BAH14707.1.
AC098935 Genomic DNA. No translation available.
CH471100 Genomic DNA. Translation: EAW93517.1.
BC006401 mRNA. Translation: AAH06401.1.
CCDSiCCDS1473.1. [O60667-1]
CCDS44304.1. [O60667-2]
CCDS53467.1. [O60667-3]
RefSeqiNP_001135945.1. NM_001142473.1. [O60667-2]
NP_001180267.1. NM_001193338.1. [O60667-3]
NP_005440.1. NM_005449.4. [O60667-1]
UniGeneiHs.58831.
Hs.744273.

Genome annotation databases

EnsembliENST00000367091; ENSP00000356058; ENSG00000162894. [O60667-1]
ENST00000442471; ENSP00000404136; ENSG00000162894. [O60667-2]
ENST00000628511; ENSP00000485739; ENSG00000162894. [O60667-3]
GeneIDi9214.
KEGGihsa:9214.
UCSCiuc001hey.4. human. [O60667-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057557 mRNA. Translation: AAC18830.1.
HM480394 mRNA. Translation: ADK11426.1.
BT006797 mRNA. Translation: AAP35443.1.
AK292007 mRNA. Translation: BAF84696.1.
AK301187 mRNA. Translation: BAH13426.1.
AK316336 mRNA. Translation: BAH14707.1.
AC098935 Genomic DNA. No translation available.
CH471100 Genomic DNA. Translation: EAW93517.1.
BC006401 mRNA. Translation: AAH06401.1.
CCDSiCCDS1473.1. [O60667-1]
CCDS44304.1. [O60667-2]
CCDS53467.1. [O60667-3]
RefSeqiNP_001135945.1. NM_001142473.1. [O60667-2]
NP_001180267.1. NM_001193338.1. [O60667-3]
NP_005440.1. NM_005449.4. [O60667-1]
UniGeneiHs.58831.
Hs.744273.

3D structure databases

ProteinModelPortaliO60667.
SMRiO60667.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114648. 3 interactors.
IntActiO60667. 1 interactor.
STRINGi9606.ENSP00000356058.

PTM databases

iPTMnetiO60667.
PhosphoSitePlusiO60667.

Polymorphism and mutation databases

BioMutaiFAIM3.

Proteomic databases

PaxDbiO60667.
PeptideAtlasiO60667.
PRIDEiO60667.

Protocols and materials databases

DNASUi9214.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367091; ENSP00000356058; ENSG00000162894. [O60667-1]
ENST00000442471; ENSP00000404136; ENSG00000162894. [O60667-2]
ENST00000628511; ENSP00000485739; ENSG00000162894. [O60667-3]
GeneIDi9214.
KEGGihsa:9214.
UCSCiuc001hey.4. human. [O60667-1]

Organism-specific databases

CTDi9214.
DisGeNETi9214.
GeneCardsiFAIM3.
HGNCiHGNC:14315. FCMR.
HPAiHPA003910.
MIMi606015. gene.
neXtProtiNX_O60667.
OpenTargetsiENSG00000162894.
PharmGKBiPA142671899.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ2J. Eukaryota.
ENOG41113GQ. LUCA.
GeneTreeiENSGT00530000063436.
HOGENOMiHOG000013142.
HOVERGENiHBG107910.
InParanoidiO60667.
OMAiTIECPLP.
OrthoDBiEOG091G0K4T.
PhylomeDBiO60667.
TreeFamiTF338713.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162894-MONOMER.

Miscellaneous databases

ChiTaRSiFAIM3. human.
GenomeRNAii9214.
PROiO60667.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162894.
CleanExiHS_FAIM3.
ExpressionAtlasiO60667. baseline and differential.
GenevisibleiO60667. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFAIM3_HUMAN
AccessioniPrimary (citable) accession number: O60667
Secondary accession number(s): A8K7J2, B7Z6Z0, D9MWM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

'Toso' is a Japanese liquor drunk on New Year's day to celebrate long life and eternal youth.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.