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Protein

Perilipin-3

Gene

PLIN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.1 Publication

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

GO - Biological processi

  • vesicle-mediated transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105355-MONOMER.
ReactomeiR-HSA-535734. Fatty acid, triacylglycerol, and ketone body metabolism.
R-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
Perilipin-3
Alternative name(s):
47 kDa mannose 6-phosphate receptor-binding protein
Short name:
47 kDa MPR-binding protein
Cargo selection protein TIP47
Mannose-6-phosphate receptor-binding protein 1
Placental protein 17
Short name:
PP17
Gene namesi
Name:PLIN3
Synonyms:M6PRBP1, TIP47
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:16893. PLIN3.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • endosome Source: ProtInc
  • endosome membrane Source: UniProtKB-SubCell
  • Golgi apparatus Source: ProtInc
  • intracellular membrane-bounded organelle Source: HPA
  • lipid particle Source: UniProtKB
  • membrane Source: UniProtKB
  • transport vesicle Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Lipid droplet, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10226.
OpenTargetsiENSG00000105355.
PharmGKBiPA165394001.

Chemistry databases

DrugBankiDB01279. Galsulfase.
DB01271. Idursulfase.

Polymorphism and mutation databases

BioMutaiPLIN3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000998902 – 434Perilipin-3Add BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei65N6-acetyllysineCombined sources1
Modified residuei91PhosphoserineCombined sources1
Cross-linki122Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei130PhosphoserineCombined sources1
Modified residuei148PhosphoserineCombined sources1
Modified residuei170PhosphothreonineCombined sources1
Modified residuei175PhosphoserineCombined sources1
Modified residuei179PhosphoserineCombined sources1
Modified residuei216PhosphothreonineCombined sources1
Modified residuei217PhosphoserineCombined sources1
Modified residuei241PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO60664.
MaxQBiO60664.
PaxDbiO60664.
PeptideAtlasiO60664.
PRIDEiO60664.
TopDownProteomicsiO60664-1. [O60664-1]
O60664-2. [O60664-2]
O60664-3. [O60664-3]

2D gel databases

REPRODUCTION-2DPAGEIPI00303882.

PTM databases

iPTMnetiO60664.
PhosphoSitePlusiO60664.
SwissPalmiO60664.

Miscellaneous databases

PMAP-CutDBO60664.

Expressioni

Gene expression databases

BgeeiENSG00000105355.
CleanExiHS_M6PRBP1.
ExpressionAtlasiO60664. baseline and differential.
GenevisibleiO60664. HS.

Organism-specific databases

HPAiHPA006427.
HPA066538.

Interactioni

Subunit structurei

Homooligomer. Interacts with M6PR (via the cytoplasmic domain). Interacts with IGF2R (via the cytoplasmic domain). Isoform 2 may exist as a homodimer (known as PP17C).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Q9WMX25EBI-725795,EBI-6863748From a different organism.
CMTM5Q96DZ93EBI-725795,EBI-2548702

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi115520. 69 interactors.
IntActiO60664. 15 interactors.
MINTiMINT-5000803.
STRINGi9606.ENSP00000221957.

Structurei

3D structure databases

ProteinModelPortaliO60664.
SMRiO60664.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili252 – 277Sequence analysisAdd BLAST26
Coiled coili353 – 377Sequence analysisAdd BLAST25

Sequence similaritiesi

Belongs to the perilipin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJG1. Eukaryota.
ENOG410XTQ5. LUCA.
GeneTreeiENSGT00500000044795.
HOGENOMiHOG000033816.
HOVERGENiHBG002935.
InParanoidiO60664.
KOiK20287.
OMAiWADNHLP.
OrthoDBiEOG091G0D6Q.
PhylomeDBiO60664.
TreeFamiTF328397.

Family and domain databases

InterProiIPR004279. Perilipin.
[Graphical view]
PANTHERiPTHR14024. PTHR14024. 1 hit.
PfamiPF03036. Perilipin. 1 hit.
[Graphical view]
PIRSFiPIRSF036881. PAT. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60664-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSADGAEADG STQVTVEEPV QQPSVVDRVA SMPLISSTCD MVSAAYASTK
60 70 80 90 100
ESYPHIKTVC DAAEKGVRTL TAAAVSGAQP ILSKLEPQIA SASEYAHRGL
110 120 130 140 150
DKLEENLPIL QQPTEKVLAD TKELVSSKVS GAQEMVSSAK DTVATQLSEA
160 170 180 190 200
VDATRGAVQS GVDKTKSVVT GGVQSVMGSR LGQMVLSGVD TVLGKSEEWA
210 220 230 240 250
DNHLPLTDAE LARIATSLDG FDVASVQQQR QEQSYFVRLG SLSERLRQHA
260 270 280 290 300
YEHSLGKLRA TKQRAQEALL QLSQVLSLME TVKQGVDQKL VEGQEKLHQM
310 320 330 340 350
WLSWNQKQLQ GPEKEPPKPE QVESRALTMF RDIAQQLQAT CTSLGSSIQG
360 370 380 390 400
LPTNVKDQVQ QARRQVEDLQ ATFSSIHSFQ DLSSSILAQS RERVASAREA
410 420 430
LDHMVEYVAQ NTPVTWLVGP FAPGITEKAP EEKK
Note: PP17b.
Length:434
Mass (Da):47,075
Last modified:January 11, 2011 - v3
Checksum:i67B2B9CDBC523043
GO
Isoform 2 (identifier: O60664-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-183: Missing.

Note: PP17a.
Show »
Length:251
Mass (Da):28,158
Checksum:i3C7AEC3FBE9429DF
GO
Isoform 3 (identifier: O60664-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     321-321: Missing.

Show »
Length:433
Mass (Da):46,947
Checksum:i8716B72B11C7FE65
GO
Isoform 4 (identifier: O60664-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-127: Missing.

Note: No experimental confirmation available.
Show »
Length:422
Mass (Da):45,803
Checksum:iDB98F133BF2A206E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77G → W in AAD11622 (PubMed:9874244).Curated1
Sequence conflicti109 – 111ILQ → MLR in AAD11622 (PubMed:9874244).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02278056I → V.4 PublicationsCorresponds to variant rs8289dbSNPEnsembl.1
Natural variantiVAR_024559275V → A.7 PublicationsCorresponds to variant rs9973235dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0046641 – 183Missing in isoform 2. 2 PublicationsAdd BLAST183
Alternative sequenceiVSP_047038116 – 127Missing in isoform 4. CuratedAdd BLAST12
Alternative sequenceiVSP_040325321Missing in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057140 mRNA. Translation: AAC39751.1.
AF055574 mRNA. Translation: AAD11622.1.
AF051314 mRNA. Translation: AAD11619.1.
AF051315 mRNA. Translation: AAD11620.1.
BT007235 mRNA. Translation: AAP35899.1.
AK291104 mRNA. Translation: BAF83793.1.
AK223054 mRNA. Translation: BAD96774.1.
AK225045 mRNA. No translation available.
AC027319 Genomic DNA. No translation available.
BC001590 mRNA. Translation: AAH01590.1.
BC005818 mRNA. Translation: AAH05818.1.
BC007566 mRNA. Translation: AAH07566.1.
BC019278 mRNA. Translation: AAH19278.1.
CCDSiCCDS12137.1. [O60664-1]
CCDS59337.1. [O60664-4]
CCDS59338.1. [O60664-3]
RefSeqiNP_001157661.1. NM_001164189.1. [O60664-3]
NP_001157666.1. NM_001164194.1. [O60664-4]
NP_005808.3. NM_005817.4. [O60664-1]
UniGeneiHs.140452.

Genome annotation databases

EnsembliENST00000221957; ENSP00000221957; ENSG00000105355. [O60664-1]
ENST00000585479; ENSP00000465596; ENSG00000105355. [O60664-3]
ENST00000592528; ENSP00000467803; ENSG00000105355. [O60664-4]
GeneIDi10226.
KEGGihsa:10226.
UCSCiuc002mbj.3. human. [O60664-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057140 mRNA. Translation: AAC39751.1.
AF055574 mRNA. Translation: AAD11622.1.
AF051314 mRNA. Translation: AAD11619.1.
AF051315 mRNA. Translation: AAD11620.1.
BT007235 mRNA. Translation: AAP35899.1.
AK291104 mRNA. Translation: BAF83793.1.
AK223054 mRNA. Translation: BAD96774.1.
AK225045 mRNA. No translation available.
AC027319 Genomic DNA. No translation available.
BC001590 mRNA. Translation: AAH01590.1.
BC005818 mRNA. Translation: AAH05818.1.
BC007566 mRNA. Translation: AAH07566.1.
BC019278 mRNA. Translation: AAH19278.1.
CCDSiCCDS12137.1. [O60664-1]
CCDS59337.1. [O60664-4]
CCDS59338.1. [O60664-3]
RefSeqiNP_001157661.1. NM_001164189.1. [O60664-3]
NP_001157666.1. NM_001164194.1. [O60664-4]
NP_005808.3. NM_005817.4. [O60664-1]
UniGeneiHs.140452.

3D structure databases

ProteinModelPortaliO60664.
SMRiO60664.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115520. 69 interactors.
IntActiO60664. 15 interactors.
MINTiMINT-5000803.
STRINGi9606.ENSP00000221957.

Chemistry databases

DrugBankiDB01279. Galsulfase.
DB01271. Idursulfase.

PTM databases

iPTMnetiO60664.
PhosphoSitePlusiO60664.
SwissPalmiO60664.

Polymorphism and mutation databases

BioMutaiPLIN3.

2D gel databases

REPRODUCTION-2DPAGEIPI00303882.

Proteomic databases

EPDiO60664.
MaxQBiO60664.
PaxDbiO60664.
PeptideAtlasiO60664.
PRIDEiO60664.
TopDownProteomicsiO60664-1. [O60664-1]
O60664-2. [O60664-2]
O60664-3. [O60664-3]

Protocols and materials databases

DNASUi10226.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221957; ENSP00000221957; ENSG00000105355. [O60664-1]
ENST00000585479; ENSP00000465596; ENSG00000105355. [O60664-3]
ENST00000592528; ENSP00000467803; ENSG00000105355. [O60664-4]
GeneIDi10226.
KEGGihsa:10226.
UCSCiuc002mbj.3. human. [O60664-1]

Organism-specific databases

CTDi10226.
DisGeNETi10226.
GeneCardsiPLIN3.
H-InvDBHIX0014673.
HGNCiHGNC:16893. PLIN3.
HPAiHPA006427.
HPA066538.
MIMi602702. gene.
neXtProtiNX_O60664.
OpenTargetsiENSG00000105355.
PharmGKBiPA165394001.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJG1. Eukaryota.
ENOG410XTQ5. LUCA.
GeneTreeiENSGT00500000044795.
HOGENOMiHOG000033816.
HOVERGENiHBG002935.
InParanoidiO60664.
KOiK20287.
OMAiWADNHLP.
OrthoDBiEOG091G0D6Q.
PhylomeDBiO60664.
TreeFamiTF328397.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105355-MONOMER.
ReactomeiR-HSA-535734. Fatty acid, triacylglycerol, and ketone body metabolism.
R-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.

Miscellaneous databases

ChiTaRSiPLIN3. human.
GeneWikiiM6PRBP1.
GenomeRNAii10226.
PMAP-CutDBO60664.
PROiO60664.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105355.
CleanExiHS_M6PRBP1.
ExpressionAtlasiO60664. baseline and differential.
GenevisibleiO60664. HS.

Family and domain databases

InterProiIPR004279. Perilipin.
[Graphical view]
PANTHERiPTHR14024. PTHR14024. 1 hit.
PfamiPF03036. Perilipin. 1 hit.
[Graphical view]
PIRSFiPIRSF036881. PAT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLIN3_HUMAN
AccessioniPrimary (citable) accession number: O60664
Secondary accession number(s): A8K4Y9
, K7EQF4, Q53G77, Q9BS03, Q9UBD7, Q9UP92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 11, 2011
Last modified: November 2, 2016
This is version 159 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.