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Protein

Perilipin-3

Gene

PLIN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.1 Publication

GO - Biological processi

  • vesicle-mediated transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Perilipin-3
Alternative name(s):
47 kDa mannose 6-phosphate receptor-binding protein
Short name:
47 kDa MPR-binding protein
Cargo selection protein TIP47
Mannose-6-phosphate receptor-binding protein 1
Placental protein 17
Short name:
PP17
Gene namesi
Name:PLIN3
Synonyms:M6PRBP1, TIP47
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:16893. PLIN3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • endosome Source: ProtInc
  • endosome membrane Source: UniProtKB-SubCell
  • Golgi apparatus Source: ProtInc
  • intracellular membrane-bounded organelle Source: HPA
  • lipid particle Source: UniProtKB
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Lipid droplet, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165394001.

Chemistry

DrugBankiDB01279. Galsulfase.
DB01271. Idursulfase.

Polymorphism and mutation databases

BioMutaiPLIN3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 434433Perilipin-3PRO_0000099890Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine3 Publications
Modified residuei65 – 651N6-acetyllysine1 Publication
Modified residuei130 – 1301Phosphoserine2 Publications
Modified residuei170 – 1701Phosphothreonine1 Publication
Modified residuei175 – 1751Phosphoserine1 Publication
Modified residuei179 – 1791Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO60664.
PaxDbiO60664.
PRIDEiO60664.

2D gel databases

REPRODUCTION-2DPAGEIPI00303882.

PTM databases

PhosphoSiteiO60664.

Miscellaneous databases

PMAP-CutDBO60664.

Expressioni

Gene expression databases

BgeeiO60664.
CleanExiHS_M6PRBP1.
ExpressionAtlasiO60664. baseline and differential.
GenevisibleiO60664. HS.

Organism-specific databases

HPAiHPA006427.

Interactioni

Subunit structurei

Homooligomer. Interacts with M6PR (via the cytoplasmic domain). Interacts with IGF2R (via the cytoplasmic domain). Isoform 2 may exist as a homodimer (known as PP17C).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Q9WMX25EBI-725795,EBI-6863748From a different organism.
CMTM5Q96DZ93EBI-725795,EBI-2548702

Protein-protein interaction databases

BioGridi115520. 49 interactions.
IntActiO60664. 12 interactions.
MINTiMINT-5000803.
STRINGi9606.ENSP00000221957.

Structurei

3D structure databases

ProteinModelPortaliO60664.
SMRiO60664. Positions 202-427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili252 – 27726Sequence AnalysisAdd
BLAST
Coiled coili353 – 37725Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the perilipin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG81115.
GeneTreeiENSGT00500000044795.
HOGENOMiHOG000033816.
HOVERGENiHBG002935.
InParanoidiO60664.
OMAiQEQSYFV.
OrthoDBiEOG7SN8CD.
PhylomeDBiO60664.
TreeFamiTF328397.

Family and domain databases

InterProiIPR004279. Perilipin.
[Graphical view]
PANTHERiPTHR14024. PTHR14024. 1 hit.
PfamiPF03036. Perilipin. 1 hit.
[Graphical view]
PIRSFiPIRSF036881. PAT. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60664-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSADGAEADG STQVTVEEPV QQPSVVDRVA SMPLISSTCD MVSAAYASTK
60 70 80 90 100
ESYPHIKTVC DAAEKGVRTL TAAAVSGAQP ILSKLEPQIA SASEYAHRGL
110 120 130 140 150
DKLEENLPIL QQPTEKVLAD TKELVSSKVS GAQEMVSSAK DTVATQLSEA
160 170 180 190 200
VDATRGAVQS GVDKTKSVVT GGVQSVMGSR LGQMVLSGVD TVLGKSEEWA
210 220 230 240 250
DNHLPLTDAE LARIATSLDG FDVASVQQQR QEQSYFVRLG SLSERLRQHA
260 270 280 290 300
YEHSLGKLRA TKQRAQEALL QLSQVLSLME TVKQGVDQKL VEGQEKLHQM
310 320 330 340 350
WLSWNQKQLQ GPEKEPPKPE QVESRALTMF RDIAQQLQAT CTSLGSSIQG
360 370 380 390 400
LPTNVKDQVQ QARRQVEDLQ ATFSSIHSFQ DLSSSILAQS RERVASAREA
410 420 430
LDHMVEYVAQ NTPVTWLVGP FAPGITEKAP EEKK
Note: PP17b.
Length:434
Mass (Da):47,075
Last modified:January 11, 2011 - v3
Checksum:i67B2B9CDBC523043
GO
Isoform 2 (identifier: O60664-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-183: Missing.

Note: PP17a.
Show »
Length:251
Mass (Da):28,158
Checksum:i3C7AEC3FBE9429DF
GO
Isoform 3 (identifier: O60664-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     321-321: Missing.

Show »
Length:433
Mass (Da):46,947
Checksum:i8716B72B11C7FE65
GO
Isoform 4 (identifier: O60664-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-127: Missing.

Note: No experimental confirmation available.
Show »
Length:422
Mass (Da):45,803
Checksum:iDB98F133BF2A206E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 771G → W in AAD11622 (PubMed:9874244).Curated
Sequence conflicti109 – 1113ILQ → MLR in AAD11622 (PubMed:9874244).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti56 – 561I → V.4 Publications
Corresponds to variant rs8289 [ dbSNP | Ensembl ].
VAR_022780
Natural varianti275 – 2751V → A.7 Publications
Corresponds to variant rs9973235 [ dbSNP | Ensembl ].
VAR_024559

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 183183Missing in isoform 2. 2 PublicationsVSP_004664Add
BLAST
Alternative sequencei116 – 12712Missing in isoform 4. CuratedVSP_047038Add
BLAST
Alternative sequencei321 – 3211Missing in isoform 3. 1 PublicationVSP_040325

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057140 mRNA. Translation: AAC39751.1.
AF055574 mRNA. Translation: AAD11622.1.
AF051314 mRNA. Translation: AAD11619.1.
AF051315 mRNA. Translation: AAD11620.1.
BT007235 mRNA. Translation: AAP35899.1.
AK291104 mRNA. Translation: BAF83793.1.
AK223054 mRNA. Translation: BAD96774.1.
AK225045 mRNA. No translation available.
AC027319 Genomic DNA. No translation available.
BC001590 mRNA. Translation: AAH01590.1.
BC005818 mRNA. Translation: AAH05818.1.
BC007566 mRNA. Translation: AAH07566.1.
BC019278 mRNA. Translation: AAH19278.1.
CCDSiCCDS12137.1. [O60664-1]
CCDS59337.1. [O60664-4]
CCDS59338.1. [O60664-3]
RefSeqiNP_001157661.1. NM_001164189.1. [O60664-3]
NP_001157666.1. NM_001164194.1. [O60664-4]
NP_005808.3. NM_005817.4. [O60664-1]
UniGeneiHs.140452.

Genome annotation databases

EnsembliENST00000221957; ENSP00000221957; ENSG00000105355. [O60664-1]
ENST00000585479; ENSP00000465596; ENSG00000105355. [O60664-3]
ENST00000592528; ENSP00000467803; ENSG00000105355. [O60664-4]
GeneIDi10226.
KEGGihsa:10226.
UCSCiuc002mbj.2. human. [O60664-1]
uc002mbl.3. human. [O60664-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057140 mRNA. Translation: AAC39751.1.
AF055574 mRNA. Translation: AAD11622.1.
AF051314 mRNA. Translation: AAD11619.1.
AF051315 mRNA. Translation: AAD11620.1.
BT007235 mRNA. Translation: AAP35899.1.
AK291104 mRNA. Translation: BAF83793.1.
AK223054 mRNA. Translation: BAD96774.1.
AK225045 mRNA. No translation available.
AC027319 Genomic DNA. No translation available.
BC001590 mRNA. Translation: AAH01590.1.
BC005818 mRNA. Translation: AAH05818.1.
BC007566 mRNA. Translation: AAH07566.1.
BC019278 mRNA. Translation: AAH19278.1.
CCDSiCCDS12137.1. [O60664-1]
CCDS59337.1. [O60664-4]
CCDS59338.1. [O60664-3]
RefSeqiNP_001157661.1. NM_001164189.1. [O60664-3]
NP_001157666.1. NM_001164194.1. [O60664-4]
NP_005808.3. NM_005817.4. [O60664-1]
UniGeneiHs.140452.

3D structure databases

ProteinModelPortaliO60664.
SMRiO60664. Positions 202-427.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115520. 49 interactions.
IntActiO60664. 12 interactions.
MINTiMINT-5000803.
STRINGi9606.ENSP00000221957.

Chemistry

DrugBankiDB01279. Galsulfase.
DB01271. Idursulfase.

PTM databases

PhosphoSiteiO60664.

Polymorphism and mutation databases

BioMutaiPLIN3.

2D gel databases

REPRODUCTION-2DPAGEIPI00303882.

Proteomic databases

MaxQBiO60664.
PaxDbiO60664.
PRIDEiO60664.

Protocols and materials databases

DNASUi10226.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221957; ENSP00000221957; ENSG00000105355. [O60664-1]
ENST00000585479; ENSP00000465596; ENSG00000105355. [O60664-3]
ENST00000592528; ENSP00000467803; ENSG00000105355. [O60664-4]
GeneIDi10226.
KEGGihsa:10226.
UCSCiuc002mbj.2. human. [O60664-1]
uc002mbl.3. human. [O60664-3]

Organism-specific databases

CTDi10226.
GeneCardsiGC19M004839.
H-InvDBHIX0014673.
HGNCiHGNC:16893. PLIN3.
HPAiHPA006427.
MIMi602702. gene.
neXtProtiNX_O60664.
PharmGKBiPA165394001.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG81115.
GeneTreeiENSGT00500000044795.
HOGENOMiHOG000033816.
HOVERGENiHBG002935.
InParanoidiO60664.
OMAiQEQSYFV.
OrthoDBiEOG7SN8CD.
PhylomeDBiO60664.
TreeFamiTF328397.

Miscellaneous databases

ChiTaRSiPLIN3. human.
GeneWikiiM6PRBP1.
GenomeRNAii10226.
NextBioi38722.
PMAP-CutDBO60664.
PROiO60664.
SOURCEiSearch...

Gene expression databases

BgeeiO60664.
CleanExiHS_M6PRBP1.
ExpressionAtlasiO60664. baseline and differential.
GenevisibleiO60664. HS.

Family and domain databases

InterProiIPR004279. Perilipin.
[Graphical view]
PANTHERiPTHR14024. PTHR14024. 1 hit.
PfamiPF03036. Perilipin. 1 hit.
[Graphical view]
PIRSFiPIRSF036881. PAT. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking."
    Diaz E., Pfeffer S.R.
    Cell 93:433-443(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS VAL-56 AND ALA-275, FUNCTION, INTERACTION WITH M6PR AND IGF2R, HOMOOLIGOMERIZATION, SUBCELLULAR LOCATION.
  2. "Cloning and sequence analysis of cDNAs encoding human placental tissue protein 17 (PP17) variants."
    Than N.G., Sumegi B., Than G.N., Kispal G., Bohn H.
    Eur. J. Biochem. 258:752-757(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS VAL-56 AND ALA-275.
    Tissue: Placenta.
  3. "Cloning and sequencing of human oncodevelopmental soluble placental tissue protein 17 (PP17): homology with adipophilin and the mouse adipose differentiation-related protein."
    Than N.G., Sumegi B., Than G.N., Kispal G., Bohn H.
    Tumor Biol. 20:184-192(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS VAL-56 AND ALA-275.
    Tissue: Placenta.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-275.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-275.
  6. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ALA-275.
  7. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-56 AND ALA-275.
    Tissue: Colon and Muscle.
  9. "Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17)."
    Bohn H., Kraus W., Winckler W.
    Oncodev. Biol. Med. 4:343-350(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
    Tissue: Placenta.
  10. "Spatial integration of TIP47 and adipophilin in macrophage lipid bodies."
    Robenek H., Lorkowski S., Schnoor M., Troyer D.
    J. Biol. Chem. 280:5789-5794(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130; THR-170; SER-175 AND SER-179, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  17. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPLIN3_HUMAN
AccessioniPrimary (citable) accession number: O60664
Secondary accession number(s): A8K4Y9
, K7EQF4, Q53G77, Q9BS03, Q9UBD7, Q9UP92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 11, 2011
Last modified: June 24, 2015
This is version 144 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.