Reviewed,
UniProtKB/Swiss-Prot O60656 (UD19_HUMAN)
Last modified
July 7, 2009.
Version 70.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: UDP-glucuronosyltransferase 1-9 EC=2.4.1.17 Alternative name(s): UDP-glucuronosyltransferase 1A9 Short name=UDPGT Short name=UGT1*9 Short name=UGT1-9 Short name=UGT1.9 UGT-1I Short name=UGT1I lugP4 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 530 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. |
| Catalytic activity | UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. |
| Subcellular location | Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential. |
| Tissue specificity | Liver. |
| Sequence similarities | Belongs to the UDP-glycosyltransferase family. |
| Sequence caution | The sequence AAB19791.2 differs from that shown. Reason: Frameshift at positions 59 and 82. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Endoplasmic reticulum Membrane Microsome |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Signal Transmembrane |
| Molecular function | Glycosyltransferase Transferase |
| PTM | Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | xenobiotic metabolic process Ref.1 Inferred from direct assay. Source: UniProtKB |
| Cellular component | endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membraneInferred from electronic annotation. Source: UniProtKB-KW microsomeNon-traceable author statement. Source: UniProtKB |
| Molecular function | glucuronosyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Alternative products
| This entry describes 1 isoform produced by alternative splicing. [Select] Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues. | ||||||
| Isoform 1 (identifier: O60656-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 25 | 25 | Potential | ||||||
| Chain | 26 – 530 | 505 | UDP-glucuronosyltransferase 1-9 | PRO_0000036008 | |||||
Regions | |||||||||
| Transmembrane | 488 – 504 | 17 | Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 71 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 292 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 344 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Natural variant | 442 | 1 | S → I in a breast cancer sample; somatic mutation. Ref.6 | VAR_036035 | |||||
Experimental info | |||||||||
| Sequence conflict | 29 | 1 | L → V in AAB19791. Ref.1 | ||||||
| Sequence conflict | 200 | 1 | A → D in AAB19791. Ref.1 | ||||||
| Sequence conflict | 279 – 282 | 4 | QGKP → ERKA in AAB19791. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronosyltransferase cDNA family." Wooster R., Sutherland L., Ebner T., Clarke D., da Cruz e Silva O., Burchell B. Biochem. J. 278:465-469(1991) [PubMed: 1910331] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver. |
| [2] | "Human phenol metabolizing UDP-glucuronosyltransferase." Ciotti M., Potter C., Owens I.S. Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver. |
| [3] | "Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus." Gong Q.H., Cho J.W., Huang T., Potter C., Gholami N., Basu N.K., Kubota S., Carvalho S., Pennington M.W., Owens I.S., Popescu N.C. Pharmacogenetics 11:357-368(2001) [PubMed: 11434514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney. |
| [5] | "Human phenol UDP-glucuronosyltransferase (UGT1A9) gene isozyme exon 1." Owens I.S., Gong Q., Cho J.W., Potter C., Gholami N. Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-285. |
| [6] | "The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E.Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-442. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| S55985 mRNA. Translation: AAB19791.2. Frameshift. AF056188 mRNA. Translation: AAC31425.1. AF297093 Genomic DNA. Translation: AAG30418.1. BC058844 mRNA. Translation: AAH58844.1. AF297091 Genomic DNA. Translation: AAG29816.1. | |
| IPI | IPI00426542. |
| PIR | S17512. |
| RefSeq | NP_066307.1. |
| UniGene | Hs.554822 |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| CAZy | GT1. Glycosyltransferase Family 1. |
Proteomic databases | |
| PRIDE | O60656. |
Genome annotation databases | |
| Ensembl | ENSG00000167165. Homo sapiens. [Contig view] |
| GeneID | 54600. |
| KEGG | hsa:54600. |
| UCSC | uc002vus.1. human. |
Organism-specific databases | |
| GeneCards | GC02P234210. |
| HGNC | HGNC:12541. UGT1A9. |
| MIM | 191740. gene. 606434. gene. |
| Orphanet | 205. Crigler-Najjar syndrome. 357. Gilbert syndrome. 2312. Hyperbilirubinemia transient familial neonatal. |
| PharmGKB | PA419. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | O60656. |
| OMA | O60656. ILCHYLE. |
Enzyme and pathway databases | |
| BRENDA | 2.4.1.17. 247. |
| Reactome | REACT_13433. Biological oxidations. |
Gene expression databases | |
| ArrayExpress | O60656. |
| Bgee | O60656. |
| GermOnline | ENSG00000167165. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR002213. UDP_glucos_trans. [Graphical view] |
| PANTHER | PTHR11926. UDP_glucos_trans. 1 hit. |
| Pfam | PF00201. UDPGT. 1 hit. [Graphical view] |
| PROSITE | PS00375. UDPGT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| DrugBank | DB00494. Entacapone. DB00749. Etodolac. DB00328. Indomethacin. DB00762. Irinotecan. DB01024. Mycophenolic acid. DB00219. Oxyphenonium. DB00818. Propofol. DB00398. Sorafenib. |
| NextBio | 57125. |
| SOURCE | Search... |
Entry information
| Entry name | UD19_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O60656 Secondary accession number(s): P36509, Q9HAX0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 2 Human chromosome 2: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


