Reviewed, UniProtKB/Swiss-Prot O60656 (UD19_HUMAN)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 1-9
    EC=2.4.1.17
Alternative name(s):
    UDP-glucuronosyltransferase 1A9
      Short name=UDPGT
      Short name=UGT1*9
      Short name=UGT1-9
      Short name=UGT1.9
    UGT-1I
      Short name=UGT1I
    lugP4

Gene names

Name:	UGT1A9
Synonyms:	GNT1, UGT1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Tissue specificity	Liver.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.
Sequence caution	The sequence AAB19791.2 differs from that shown. Reason: Frameshift at positions 59 and 82.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	xenobiotic metabolic process Ref.1 Inferred from direct assay. Source: UniProtKB
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Non-traceable author statement. Source: UniProtKB
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: O60656-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 530	505	UDP-glucuronosyltransferase 1-9		PRO_0000036008
Regions
	Transmembrane	488 – 504	17	Potential
Amino acid modifications
	Glycosylation	71	1	N-linked (GlcNAc...) Potential
	Glycosylation	292	1	N-linked (GlcNAc...) Potential
	Glycosylation	344	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	442	1	S → I in a breast cancer sample; somatic mutation. Ref.6		VAR_036035
Experimental info
	Sequence conflict	29	1	L → V in AAB19791. Ref.1
	Sequence conflict	200	1	A → D in AAB19791. Ref.1
	Sequence conflict	279 – 282	4	QGKP → ERKA in AAB19791. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: C417B9E86B403078	FASTA	530	59,941
	10 20 30 40 50 60 MACTGWTSPL PLCVCLLLTC GFAEAGKLLV VPMDGSHWFT MRSVVEKLIL RGHEVVVVMP 70 80 90 100 110 120 EVSWQLGRSL NCTVKTYSTS YTLEDLDREF KAFAHAQWKA QVRSIYSLLM GSYNDIFDLF 130 140 150 160 170 180 FSNCRSLFKD KKLVEYLKES SFDAVFLDPF DNCGLIVAKY FSLPSVVFAR GILCHYLEEG 190 200 210 220 230 240 AQCPAPLSYV PRILLGFSDA MTFKERVRNH IMHLEEHLLC HRFFKNALEI ASEILQTPVT 250 260 270 280 290 300 EYDLYSHTSI WLLRTDFVLD YPKPVMPNMI FIGGINCHQG KPLPMEFEAY INASGEHGIV 310 320 330 340 350 360 VFSLGSMVSE IPEKKAMAIA DALGKIPQTV LWRYTGTRPS NLANNTILVK WLPQNDLLGH 370 380 390 400 410 420 PMTRAFITHA GSHGVYESIC NGVPMVMMPL FGDQMDNAKR METKGAGVTL NVLEMTSEDL 430 440 450 460 470 480 ENALKAVIND KSYKENIMRL SSLHKDRPVE PLDLAVFWVE FVMRHKGAPH LRPAAHDLTW 490 500 510 520 530 YQYHSLDVIG FLLAVVLTVA FITFKCCAYG YRKCLGKKGR VKKAHKSKTH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronosyltransferase cDNA family." Wooster R., Sutherland L., Ebner T., Clarke D., da Cruz e Silva O., Burchell B. Biochem. J. 278:465-469(1991) [PubMed: 1910331] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"Human phenol metabolizing UDP-glucuronosyltransferase." Ciotti M., Potter C., Owens I.S. Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[3]	"Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus." Gong Q.H., Cho J.W., Huang T., Potter C., Gholami N., Basu N.K., Kubota S., Carvalho S., Pennington M.W., Owens I.S., Popescu N.C. Pharmacogenetics 11:357-368(2001) [PubMed: 11434514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[5]	"Human phenol UDP-glucuronosyltransferase (UGT1A9) gene isozyme exon 1." Owens I.S., Gong Q., Cho J.W., Potter C., Gholami N. Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-285.
[6]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-442.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	S55985 mRNA. Translation: AAB19791.2. Frameshift. AF056188 mRNA. Translation: AAC31425.1. AF297093 Genomic DNA. Translation: AAG30418.1. BC058844 mRNA. Translation: AAH58844.1. AF297091 Genomic DNA. Translation: AAG29816.1.
IPI	IPI00426542.
PIR	S17512.
RefSeq	NP_066307.1.
UniGene	Hs.554822
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Proteomic databases
PRIDE	O60656.
Genome annotation databases
Ensembl	ENSG00000167165. Homo sapiens. [Contig view]
GeneID	54600.
KEGG	hsa:54600.
UCSC	uc002vus.1. human.
Organism-specific databases
GeneCards	GC02P234210.
HGNC	HGNC:12541. UGT1A9.
MIM	191740. gene. 606434. gene.
Orphanet	205. Crigler-Najjar syndrome. 357. Gilbert syndrome. 2312. Hyperbilirubinemia transient familial neonatal.
PharmGKB	PA419.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	O60656.
OMA	O60656. ILCHYLE.
Enzyme and pathway databases
BRENDA	2.4.1.17. 247.
Reactome	REACT_13433. Biological oxidations.
Gene expression databases
ArrayExpress	O60656.
Bgee	O60656.
GermOnline	ENSG00000167165. Homo sapiens.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB00494. Entacapone. DB00749. Etodolac. DB00328. Indomethacin. DB00762. Irinotecan. DB01024. Mycophenolic acid. DB00219. Oxyphenonium. DB00818. Propofol. DB00398. Sorafenib.
NextBio	57125.
SOURCE	Search...

Entry information

Entry name

UD19_HUMAN

Accession

Primary (citable) accession number: O60656
Secondary accession number(s): P36509, Q9HAX0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	August 1, 1998
Last modified:	July 7, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)