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Protein

Exocyst complex component 3

Gene

EXOC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_147867. Translocation of GLUT4 to the plasma membrane.
REACT_15550. Insulin processing.
REACT_268299. VxPx cargo-targeting to cilium.

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 3
Alternative name(s):
Exocyst complex component Sec6
Gene namesi
Name:EXOC3
Synonyms:SEC6, SEC6L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:30378. EXOC3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134869816.

Polymorphism and mutation databases

BioMutaiEXOC3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 756756Exocyst complex component 3PRO_0000118925Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei39 – 391N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO60645.
PaxDbiO60645.
PRIDEiO60645.

PTM databases

PhosphoSiteiO60645.

Expressioni

Tissue specificityi

Expressed in epididymis (at protein level).1 Publication

Gene expression databases

BgeeiO60645.
CleanExiHS_EXOC3.
ExpressionAtlasiO60645. baseline and differential.
GenevisibleiO60645. HS.

Organism-specific databases

HPAiCAB017459.
HPA037880.
HPA037881.

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with EXOC3L1 (By similarity). Interacts with BIRC6/bruce. Interacts with MYRIP (By similarity).By similarity

Protein-protein interaction databases

BioGridi116464. 22 interactions.
IntActiO60645. 6 interactions.
MINTiMINT-2796954.
STRINGi9606.ENSP00000323377.

Structurei

3D structure databases

ProteinModelPortaliO60645.
SMRiO60645. Positions 390-724.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili35 – 6329Sequence AnalysisAdd
BLAST
Coiled coili632 – 64817Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the SEC6 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5173.
GeneTreeiENSGT00530000062934.
HOGENOMiHOG000043095.
HOVERGENiHBG034187.
InParanoidiO60645.
KOiK06110.
OMAiHYELTQL.
OrthoDBiEOG7X9G69.
PhylomeDBiO60645.
TreeFamiTF314979.

Family and domain databases

InterProiIPR010326. Sec6.
[Graphical view]
PANTHERiPTHR21292. PTHR21292. 1 hit.
PfamiPF06046. Sec6. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60645-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQCEDSTSFF TMKETDREAV ATAVQRVAGM LQRPDQLDKV EQYRRREARK
60 70 80 90 100
KASVEARLKA AIQSQLDGVR TGLSQLHNAL NDVKDIQQSL ADVSKDWRQS
110 120 130 140 150
INTIESLKDV KDAVVQHSQL AAAVENLKNI FSVPEIVRET QDLIEQGALL
160 170 180 190 200
QAHRKLMDLE CSRDGLMYEQ YRMDSGNTRD MTLIHGYFGS TQGLSDELAK
210 220 230 240 250
QLWMVLQRSL VTVRRDPTLL VSVVRIIERE EKIDRRILDR KKQTGFVPPG
260 270 280 290 300
RPKNWKEKMF TILERTVTTR IEGTQADTRE SDKMWLVRHL EIIRKYVLDD
310 320 330 340 350
LIVAKNLMVQ CFPPHYEIFK NLLNMYHQAL STRMQDLASE DLEANEIVSL
360 370 380 390 400
LTWVLNTYTS TEMMRNVELA PEVDVGTLEP LLSPHVVSEL LDTYMSTLTS
410 420 430 440 450
NIIAWLRKAL ETDKKDWVKE TEPEADQDGY YQTTLPAIVF QMFEQNLQVA
460 470 480 490 500
AQISEDLKTK VLVLCLQQMN SFLSRYKDEA QLYKEEHLRN RQHPHCYVQY
510 520 530 540 550
MIAIINNCQT FKESIVSLKR KYLKNEVEEG VSPSQPSMDG ILDAIAKEGC
560 570 580 590 600
SGLLEEVFLD LEQHLNELMT KKWLLGSNAV DIICVTVEDY FNDFAKIKKP
610 620 630 640 650
YKKRMTAEAH RRVVVEYLRA VMQKRISFRS PEERKEGAEK MVREAEQLRF
660 670 680 690 700
LFRKLASGFG EDVDGYCDTI VAVAEVIKLT DPSLLYLEVS TLVSKYPDIR
710 720 730 740 750
DDHIGALLAV RGDASRDMKQ TIMETLEQGP AQASPSYVPL FKDIVVPSLN

VAKLLK
Length:756
Mass (Da):86,845
Last modified:October 25, 2002 - v2
Checksum:i5B34ED2D5DE91168
GO
Isoform 2 (identifier: O60645-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     360-474: Missing.

Note: No experimental confirmation available.
Show »
Length:641
Mass (Da):73,797
Checksum:i783F7B6EE7F43A3E
GO
Isoform 3 (identifier: O60645-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.

Show »
Length:745
Mass (Da):85,567
Checksum:i81D03FB3351A995D
GO

Sequence cautioni

The sequence BAB84912.1 differs from that shown. Reason: Frameshift at positions 1 and 563. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1111Missing in isoform 3. 2 PublicationsVSP_046235Add
BLAST
Alternative sequencei360 – 474115Missing in isoform 2. 1 PublicationVSP_001482Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU727644 mRNA. Translation: ADU87645.1.
AK074086 mRNA. Translation: BAB84912.1. Frameshift.
AC010442 Genomic DNA. No translation available.
CH471235 Genomic DNA. Translation: EAW51000.1.
BC001511 mRNA. Translation: AAH01511.2.
BC019304 mRNA. Translation: AAH19304.1.
BC064569 mRNA. Translation: AAH64569.1.
AF055006 mRNA. Translation: AAC09358.1.
CCDSiCCDS54830.1. [O60645-3]
RefSeqiNP_009208.2. NM_007277.4. [O60645-3]
UniGeneiHs.481464.

Genome annotation databases

EnsembliENST00000315013; ENSP00000323377; ENSG00000180104. [O60645-3]
ENST00000512944; ENSP00000425587; ENSG00000180104. [O60645-3]
GeneIDi11336.
KEGGihsa:11336.
UCSCiuc003jba.3. human. [O60645-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU727644 mRNA. Translation: ADU87645.1.
AK074086 mRNA. Translation: BAB84912.1. Frameshift.
AC010442 Genomic DNA. No translation available.
CH471235 Genomic DNA. Translation: EAW51000.1.
BC001511 mRNA. Translation: AAH01511.2.
BC019304 mRNA. Translation: AAH19304.1.
BC064569 mRNA. Translation: AAH64569.1.
AF055006 mRNA. Translation: AAC09358.1.
CCDSiCCDS54830.1. [O60645-3]
RefSeqiNP_009208.2. NM_007277.4. [O60645-3]
UniGeneiHs.481464.

3D structure databases

ProteinModelPortaliO60645.
SMRiO60645. Positions 390-724.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116464. 22 interactions.
IntActiO60645. 6 interactions.
MINTiMINT-2796954.
STRINGi9606.ENSP00000323377.

PTM databases

PhosphoSiteiO60645.

Polymorphism and mutation databases

BioMutaiEXOC3.

Proteomic databases

MaxQBiO60645.
PaxDbiO60645.
PRIDEiO60645.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315013; ENSP00000323377; ENSG00000180104. [O60645-3]
ENST00000512944; ENSP00000425587; ENSG00000180104. [O60645-3]
GeneIDi11336.
KEGGihsa:11336.
UCSCiuc003jba.3. human. [O60645-1]

Organism-specific databases

CTDi11336.
GeneCardsiGC05P000443.
HGNCiHGNC:30378. EXOC3.
HPAiCAB017459.
HPA037880.
HPA037881.
MIMi608186. gene.
neXtProtiNX_O60645.
PharmGKBiPA134869816.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5173.
GeneTreeiENSGT00530000062934.
HOGENOMiHOG000043095.
HOVERGENiHBG034187.
InParanoidiO60645.
KOiK06110.
OMAiHYELTQL.
OrthoDBiEOG7X9G69.
PhylomeDBiO60645.
TreeFamiTF314979.

Enzyme and pathway databases

ReactomeiREACT_147867. Translocation of GLUT4 to the plasma membrane.
REACT_15550. Insulin processing.
REACT_268299. VxPx cargo-targeting to cilium.

Miscellaneous databases

GeneWikiiEXOC3.
GenomeRNAii11336.
NextBioi43071.
PROiO60645.
SOURCEiSearch...

Gene expression databases

BgeeiO60645.
CleanExiHS_EXOC3.
ExpressionAtlasiO60645. baseline and differential.
GenevisibleiO60645. HS.

Family and domain databases

InterProiIPR010326. Sec6.
[Graphical view]
PANTHERiPTHR21292. PTHR21292. 1 hit.
PfamiPF06046. Sec6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins."
    Li J., Liu F., Wang H., Liu X., Liu J., Li N., Wan F., Wang W., Zhang C., Jin S., Liu J., Zhu P., Liu Y.
    Mol. Cell. Proteomics 9:2517-2528(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
    Tissue: Epididymis.
  2. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
    Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
    DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Spleen.
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 109-756 (ISOFORM 1/3).
    Tissue: Colon, Lung and Ovary.
  6. Yu W., Gibbs R.A.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 286-756 (ISOFORM 1/3).
    Tissue: Brain.
  7. "Final stages of cytokinesis and midbody ring formation are controlled by BRUCE."
    Pohl C., Jentsch S.
    Cell 132:832-845(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BIRC6/BRUCE.
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-39, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiEXOC3_HUMAN
AccessioniPrimary (citable) accession number: O60645
Secondary accession number(s): Q6P2E8
, Q8TEN6, Q8WUW0, Q96DI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 25, 2002
Last modified: June 24, 2015
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.