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O60645 (EXOC3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Exocyst complex component 3
Alternative name(s):
Exocyst complex component Sec6
Gene names
Name:EXOC3
Synonyms:SEC6, SEC6L1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length756 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Subunit structure

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with EXOC3L1 By similarity. Interacts with BIRC6/bruce. Interacts with MYRIP By similarity. Ref.7

Tissue specificity

Expressed in epididymis (at protein level). Ref.1

Sequence similarities

Belongs to the SEC6 family.

Sequence caution

The sequence BAB84912.1 differs from that shown. Reason: Frameshift at positions 1 and 563.

Ontologies

Keywords
   Biological processExocytosis
Protein transport
Transport
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular protein metabolic process

Traceable author statement. Source: Reactome

exocytosis

Inferred from electronic annotation. Source: UniProtKB-KW

membrane organization

Traceable author statement. Source: Reactome

protein transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentexocyst

Inferred from electronic annotation. Source: InterPro

secretory granule membrane

Traceable author statement. Source: Reactome

   Molecular_functionprotein binding

Inferred from physical interaction Ref.7. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O60645-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O60645-2)

The sequence of this isoform differs from the canonical sequence as follows:
     360-474: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: O60645-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 756756Exocyst complex component 3
PRO_0000118925

Regions

Coiled coil35 – 6329 Potential
Coiled coil632 – 64817 Potential

Amino acid modifications

Modified residue391N6-acetyllysine Ref.8

Natural variations

Alternative sequence1 – 1111Missing in isoform 3.
VSP_046235
Alternative sequence360 – 474115Missing in isoform 2.
VSP_001482

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 25, 2002. Version 2.
Checksum: 5B34ED2D5DE91168

FASTA75686,845
        10         20         30         40         50         60 
MQCEDSTSFF TMKETDREAV ATAVQRVAGM LQRPDQLDKV EQYRRREARK KASVEARLKA 

        70         80         90        100        110        120 
AIQSQLDGVR TGLSQLHNAL NDVKDIQQSL ADVSKDWRQS INTIESLKDV KDAVVQHSQL 

       130        140        150        160        170        180 
AAAVENLKNI FSVPEIVRET QDLIEQGALL QAHRKLMDLE CSRDGLMYEQ YRMDSGNTRD 

       190        200        210        220        230        240 
MTLIHGYFGS TQGLSDELAK QLWMVLQRSL VTVRRDPTLL VSVVRIIERE EKIDRRILDR 

       250        260        270        280        290        300 
KKQTGFVPPG RPKNWKEKMF TILERTVTTR IEGTQADTRE SDKMWLVRHL EIIRKYVLDD 

       310        320        330        340        350        360 
LIVAKNLMVQ CFPPHYEIFK NLLNMYHQAL STRMQDLASE DLEANEIVSL LTWVLNTYTS 

       370        380        390        400        410        420 
TEMMRNVELA PEVDVGTLEP LLSPHVVSEL LDTYMSTLTS NIIAWLRKAL ETDKKDWVKE 

       430        440        450        460        470        480 
TEPEADQDGY YQTTLPAIVF QMFEQNLQVA AQISEDLKTK VLVLCLQQMN SFLSRYKDEA 

       490        500        510        520        530        540 
QLYKEEHLRN RQHPHCYVQY MIAIINNCQT FKESIVSLKR KYLKNEVEEG VSPSQPSMDG 

       550        560        570        580        590        600 
ILDAIAKEGC SGLLEEVFLD LEQHLNELMT KKWLLGSNAV DIICVTVEDY FNDFAKIKKP 

       610        620        630        640        650        660 
YKKRMTAEAH RRVVVEYLRA VMQKRISFRS PEERKEGAEK MVREAEQLRF LFRKLASGFG 

       670        680        690        700        710        720 
EDVDGYCDTI VAVAEVIKLT DPSLLYLEVS TLVSKYPDIR DDHIGALLAV RGDASRDMKQ 

       730        740        750 
TIMETLEQGP AQASPSYVPL FKDIVVPSLN VAKLLK 

« Hide

Isoform 2 [UniParc].

Checksum: 783F7B6EE7F43A3E
Show »

FASTA64173,797
Isoform 3 [UniParc].

Checksum: 81D03FB3351A995D
Show »

FASTA74585,567

References

« Hide 'large scale' references
[1]"Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins."
Li J., Liu F., Wang H., Liu X., Liu J., Li N., Wan F., Wang W., Zhang C., Jin S., Liu J., Zhu P., Liu Y.
Mol. Cell. Proteomics 9:2517-2528(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
Tissue: Epididymis.
[2]"Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Spleen.
[3]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 109-756 (ISOFORM 1/3).
Tissue: Colon, Lung and Ovary.
[6]Yu W., Gibbs R.A.
Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 286-756 (ISOFORM 1/3).
Tissue: Brain.
[7]"Final stages of cytokinesis and midbody ring formation are controlled by BRUCE."
Pohl C., Jentsch S.
Cell 132:832-845(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH BIRC6/BRUCE.
[8]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-39, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GU727644 mRNA. Translation: ADU87645.1.
AK074086 mRNA. Translation: BAB84912.1. Frameshift.
AC010442 Genomic DNA. No translation available.
CH471235 Genomic DNA. Translation: EAW51000.1.
BC001511 mRNA. Translation: AAH01511.2.
BC019304 mRNA. Translation: AAH19304.1.
BC064569 mRNA. Translation: AAH64569.1.
AF055006 mRNA. Translation: AAC09358.1.
CCDSCCDS54830.1. [O60645-3]
RefSeqNP_009208.2. NM_007277.4. [O60645-3]
XP_005248295.1. XM_005248238.1. [O60645-3]
UniGeneHs.481464.

3D structure databases

ProteinModelPortalO60645.
SMRO60645. Positions 390-724.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116464. 16 interactions.
IntActO60645. 6 interactions.
MINTMINT-2796954.
STRING9606.ENSP00000323377.

PTM databases

PhosphoSiteO60645.

Proteomic databases

MaxQBO60645.
PaxDbO60645.
PRIDEO60645.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000315013; ENSP00000323377; ENSG00000180104. [O60645-3]
ENST00000512944; ENSP00000425587; ENSG00000180104. [O60645-3]
GeneID11336.
KEGGhsa:11336.
UCSCuc003jba.3. human. [O60645-1]

Organism-specific databases

CTD11336.
GeneCardsGC05P000443.
HGNCHGNC:30378. EXOC3.
HPACAB017459.
HPA037880.
HPA037881.
MIM608186. gene.
neXtProtNX_O60645.
PharmGKBPA134869816.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5173.
HOGENOMHOG000043095.
HOVERGENHBG034187.
InParanoidO60645.
KOK06110.
OMANIRDDAM.
OrthoDBEOG7X9G69.
PhylomeDBO60645.
TreeFamTF314979.

Enzyme and pathway databases

ReactomeREACT_11123. Membrane Trafficking.
REACT_17015. Metabolism of proteins.

Gene expression databases

ArrayExpressO60645.
BgeeO60645.
CleanExHS_EXOC3.
GenevestigatorO60645.

Family and domain databases

InterProIPR010326. Sec6.
[Graphical view]
PANTHERPTHR21292. PTHR21292. 1 hit.
PfamPF06046. Sec6. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiEXOC3.
GenomeRNAi11336.
NextBio43071.
PROO60645.
SOURCESearch...

Entry information

Entry nameEXOC3_HUMAN
AccessionPrimary (citable) accession number: O60645
Secondary accession number(s): Q6P2E8 expand/collapse secondary AC list , Q8TEN6, Q8WUW0, Q96DI4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 25, 2002
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM