O60645 (EXOC3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Exocyst complex component 3

Alternative name(s):
Exocyst complex component Sec6

Gene names

Name:	EXOC3
Synonyms:	SEC6, SEC6L1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	756 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Subunit structure	The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with EXOC3L1 By similarity. Interacts with BIRC6/bruce. Interacts with MYRIP By similarity. Ref.7
Tissue specificity	Expressed in epididymis (at protein level). Ref.1
Sequence similarities	Belongs to the SEC6 family.
Sequence caution	The sequence BAB84912.1 differs from that shown. Reason: Frameshift at positions 1 and 563.

Ontologies

Keywords
Biological process	Exocytosis Protein transport Transport
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	exocytosis Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	exocyst Inferred from electronic annotation. Source: InterPro secretory granule membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O60645-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O60645-2)

The sequence of this isoform differs from the canonical sequence as follows:
     360-474: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: O60645-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 756	756	Exocyst complex component 3		PRO_0000118925
Regions
	Coiled coil	35 – 63	29	Potential
	Coiled coil	632 – 648	17	Potential
Amino acid modifications
	Modified residue	39	1	N6-acetyllysine Ref.8
Natural variations
	Alternative sequence	1 – 11	11	Missing in isoform 3.		VSP_046235
	Alternative sequence	360 – 474	115	Missing in isoform 2.		VSP_001482

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 25, 2002. Version 2. Checksum: 5B34ED2D5DE91168	FASTA	756	86,845
	10 20 30 40 50 60 MQCEDSTSFF TMKETDREAV ATAVQRVAGM LQRPDQLDKV EQYRRREARK KASVEARLKA 70 80 90 100 110 120 AIQSQLDGVR TGLSQLHNAL NDVKDIQQSL ADVSKDWRQS INTIESLKDV KDAVVQHSQL 130 140 150 160 170 180 AAAVENLKNI FSVPEIVRET QDLIEQGALL QAHRKLMDLE CSRDGLMYEQ YRMDSGNTRD 190 200 210 220 230 240 MTLIHGYFGS TQGLSDELAK QLWMVLQRSL VTVRRDPTLL VSVVRIIERE EKIDRRILDR 250 260 270 280 290 300 KKQTGFVPPG RPKNWKEKMF TILERTVTTR IEGTQADTRE SDKMWLVRHL EIIRKYVLDD 310 320 330 340 350 360 LIVAKNLMVQ CFPPHYEIFK NLLNMYHQAL STRMQDLASE DLEANEIVSL LTWVLNTYTS 370 380 390 400 410 420 TEMMRNVELA PEVDVGTLEP LLSPHVVSEL LDTYMSTLTS NIIAWLRKAL ETDKKDWVKE 430 440 450 460 470 480 TEPEADQDGY YQTTLPAIVF QMFEQNLQVA AQISEDLKTK VLVLCLQQMN SFLSRYKDEA 490 500 510 520 530 540 QLYKEEHLRN RQHPHCYVQY MIAIINNCQT FKESIVSLKR KYLKNEVEEG VSPSQPSMDG 550 560 570 580 590 600 ILDAIAKEGC SGLLEEVFLD LEQHLNELMT KKWLLGSNAV DIICVTVEDY FNDFAKIKKP 610 620 630 640 650 660 YKKRMTAEAH RRVVVEYLRA VMQKRISFRS PEERKEGAEK MVREAEQLRF LFRKLASGFG 670 680 690 700 710 720 EDVDGYCDTI VAVAEVIKLT DPSLLYLEVS TLVSKYPDIR DDHIGALLAV RGDASRDMKQ 730 740 750 TIMETLEQGP AQASPSYVPL FKDIVVPSLN VAKLLK
	Isoform 2 [UniParc]. Checksum: 783F7B6EE7F43A3E	FASTA	641	73,797
	10 20 30 40 50 60 MQCEDSTSFF TMKETDREAV ATAVQRVAGM LQRPDQLDKV EQYRRREARK KASVEARLKA 70 80 90 100 110 120 AIQSQLDGVR TGLSQLHNAL NDVKDIQQSL ADVSKDWRQS INTIESLKDV KDAVVQHSQL 130 140 150 160 170 180 AAAVENLKNI FSVPEIVRET QDLIEQGALL QAHRKLMDLE CSRDGLMYEQ YRMDSGNTRD 190 200 210 220 230 240 MTLIHGYFGS TQGLSDELAK QLWMVLQRSL VTVRRDPTLL VSVVRIIERE EKIDRRILDR 250 260 270 280 290 300 KKQTGFVPPG RPKNWKEKMF TILERTVTTR IEGTQADTRE SDKMWLVRHL EIIRKYVLDD 310 320 330 340 350 360 LIVAKNLMVQ CFPPHYEIFK NLLNMYHQAL STRMQDLASE DLEANEIVSL LTWVLNTYTR 370 380 390 400 410 420 YKDEAQLYKE EHLRNRQHPH CYVQYMIAII NNCQTFKESI VSLKRKYLKN EVEEGVSPSQ 430 440 450 460 470 480 PSMDGILDAI AKEGCSGLLE EVFLDLEQHL NELMTKKWLL GSNAVDIICV TVEDYFNDFA 490 500 510 520 530 540 KIKKPYKKRM TAEAHRRVVV EYLRAVMQKR ISFRSPEERK EGAEKMVREA EQLRFLFRKL 550 560 570 580 590 600 ASGFGEDVDG YCDTIVAVAE VIKLTDPSLL YLEVSTLVSK YPDIRDDHIG ALLAVRGDAS 610 620 630 640 RDMKQTIMET LEQGPAQASP SYVPLFKDIV VPSLNVAKLL K
	Isoform 3 [UniParc]. Checksum: 81D03FB3351A995D	FASTA	745	85,567
	10 20 30 40 50 60 MKETDREAVA TAVQRVAGML QRPDQLDKVE QYRRREARKK ASVEARLKAA IQSQLDGVRT 70 80 90 100 110 120 GLSQLHNALN DVKDIQQSLA DVSKDWRQSI NTIESLKDVK DAVVQHSQLA AAVENLKNIF 130 140 150 160 170 180 SVPEIVRETQ DLIEQGALLQ AHRKLMDLEC SRDGLMYEQY RMDSGNTRDM TLIHGYFGST 190 200 210 220 230 240 QGLSDELAKQ LWMVLQRSLV TVRRDPTLLV SVVRIIEREE KIDRRILDRK KQTGFVPPGR 250 260 270 280 290 300 PKNWKEKMFT ILERTVTTRI EGTQADTRES DKMWLVRHLE IIRKYVLDDL IVAKNLMVQC 310 320 330 340 350 360 FPPHYEIFKN LLNMYHQALS TRMQDLASED LEANEIVSLL TWVLNTYTST EMMRNVELAP 370 380 390 400 410 420 EVDVGTLEPL LSPHVVSELL DTYMSTLTSN IIAWLRKALE TDKKDWVKET EPEADQDGYY 430 440 450 460 470 480 QTTLPAIVFQ MFEQNLQVAA QISEDLKTKV LVLCLQQMNS FLSRYKDEAQ LYKEEHLRNR 490 500 510 520 530 540 QHPHCYVQYM IAIINNCQTF KESIVSLKRK YLKNEVEEGV SPSQPSMDGI LDAIAKEGCS 550 560 570 580 590 600 GLLEEVFLDL EQHLNELMTK KWLLGSNAVD IICVTVEDYF NDFAKIKKPY KKRMTAEAHR 610 620 630 640 650 660 RVVVEYLRAV MQKRISFRSP EERKEGAEKM VREAEQLRFL FRKLASGFGE DVDGYCDTIV 670 680 690 700 710 720 AVAEVIKLTD PSLLYLEVST LVSKYPDIRD DHIGALLAVR GDASRDMKQT IMETLEQGPA 730 740 QASPSYVPLF KDIVVPSLNV AKLLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins." Li J., Liu F., Wang H., Liu X., Liu J., Li N., Wan F., Wang W., Zhang C., Jin S., Liu J., Zhu P., Liu Y. Mol. Cell. Proteomics 9:2517-2528(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY. Tissue: Epididymis.
[2]	"Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones." Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O. DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Spleen.
[3]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 109-756 (ISOFORM 1/3). Tissue: Colon, Lung and Ovary.
[6]	Yu W., Gibbs R.A. Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 286-756 (ISOFORM 1/3). Tissue: Brain.
[7]	"Final stages of cytokinesis and midbody ring formation are controlled by BRUCE." Pohl C., Jentsch S. Cell 132:832-845(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH BIRC6/BRUCE.
[8]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-39, MASS SPECTROMETRY.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GU727644 mRNA. Translation: ADU87645.1. AK074086 mRNA. Translation: BAB84912.1. Frameshift. AC010442 Genomic DNA. No translation available. CH471235 Genomic DNA. Translation: EAW51000.1. BC001511 mRNA. Translation: AAH01511.2. BC019304 mRNA. Translation: AAH19304.1. BC064569 mRNA. Translation: AAH64569.1. AF055006 mRNA. Translation: AAC09358.1.
IPI	IPI00157734. IPI00219954. IPI00967947.
RefSeq	NP_009208.2. NM_007277.4.
UniGene	Hs.481464.
3D structure databases
ProteinModelPortal	O60645.
ModBase	Search...
Protein-protein interaction databases
IntAct	O60645. 5 interactions.
STRING	9606.ENSP00000323377.
PTM databases
PhosphoSite	O60645.
Proteomic databases
PaxDb	O60645.
PRIDE	O60645.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000315013; ENSP00000323377; ENSG00000180104. ENST00000512944; ENSP00000425587; ENSG00000180104.
GeneID	11336.
KEGG	hsa:11336.
UCSC	uc003jba.3. human.
Organism-specific databases
CTD	11336.
GeneCards	GC05P000443.
HGNC	HGNC:30378. EXOC3.
HPA	CAB017459.
MIM	608186. gene.
neXtProt	NX_O60645.
PharmGKB	PA134869816.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5173.
HOGENOM	HOG000043095.
HOVERGEN	HBG034187.
InParanoid	O60645.
KO	K06110.
Enzyme and pathway databases
Pathway_Interaction_DB	arf6_traffickingpathway. Arf6 trafficking events. insulin_pathway. Insulin Pathway.
Reactome	REACT_11123. Membrane Trafficking. REACT_116125. Disease.
Gene expression databases
ArrayExpress	O60645.
Bgee	O60645.
CleanEx	HS_EXOC3.
Genevestigator	O60645.
GermOnline	ENSG00000180104. Homo sapiens.
Family and domain databases
InterPro	IPR010326. Sec6. [Graphical view]
PANTHER	PTHR21292. PTHR21292. 1 hit.
Pfam	PF06046. Sec6. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	11336.
NextBio	43071.
SOURCE	Search...

Entry information

Entry name

EXOC3_HUMAN

Accession

Primary (citable) accession number: O60645
Secondary accession number(s): Q6P2E8 , Q8TEN6, Q8WUW0, Q96DI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2002
Last sequence update:	October 25, 2002
Last modified:	May 1, 2013
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.