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Protein

Exocyst complex component 3

Gene

EXOC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • SNARE binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180104-MONOMER.
ReactomeiR-HSA-1445148. Translocation of GLUT4 to the plasma membrane.
R-HSA-264876. Insulin processing.
R-HSA-5620916. VxPx cargo-targeting to cilium.

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 3
Alternative name(s):
Exocyst complex component Sec6
Gene namesi
Name:EXOC3
Synonyms:SEC6, SEC6L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:30378. EXOC3.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cytosol Source: Reactome
  • exocyst Source: GO_Central
  • secretory granule membrane Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi11336.
OpenTargetsiENSG00000180104.
PharmGKBiPA134869816.

Polymorphism and mutation databases

BioMutaiEXOC3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001189251 – 756Exocyst complex component 3Add BLAST756

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei39N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO60645.
MaxQBiO60645.
PaxDbiO60645.
PeptideAtlasiO60645.
PRIDEiO60645.

PTM databases

iPTMnetiO60645.
PhosphoSitePlusiO60645.

Expressioni

Tissue specificityi

Expressed in epididymis (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000180104.
CleanExiHS_EXOC3.
ExpressionAtlasiO60645. baseline and differential.
GenevisibleiO60645. HS.

Organism-specific databases

HPAiCAB017459.
HPA037880.
HPA037881.

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with EXOC3L1 (By similarity). Interacts with BIRC6/bruce. Interacts with MYRIP (By similarity).By similarity

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • SNARE binding Source: GO_Central

Protein-protein interaction databases

BioGridi116464. 48 interactors.
IntActiO60645. 20 interactors.
MINTiMINT-2796954.
STRINGi9606.ENSP00000323377.

Structurei

3D structure databases

ProteinModelPortaliO60645.
SMRiO60645.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili35 – 63Sequence analysisAdd BLAST29
Coiled coili632 – 648Sequence analysisAdd BLAST17

Sequence similaritiesi

Belongs to the SEC6 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2286. Eukaryota.
COG5173. LUCA.
GeneTreeiENSGT00530000062934.
HOGENOMiHOG000043095.
HOVERGENiHBG034187.
InParanoidiO60645.
KOiK06110.
OMAiIDVNKDW.
OrthoDBiEOG091G02T2.
PhylomeDBiO60645.
TreeFamiTF314979.

Family and domain databases

InterProiIPR010326. EXOC3/Sec6.
[Graphical view]
PANTHERiPTHR21292. PTHR21292. 1 hit.
PfamiPF06046. Sec6. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60645-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQCEDSTSFF TMKETDREAV ATAVQRVAGM LQRPDQLDKV EQYRRREARK
60 70 80 90 100
KASVEARLKA AIQSQLDGVR TGLSQLHNAL NDVKDIQQSL ADVSKDWRQS
110 120 130 140 150
INTIESLKDV KDAVVQHSQL AAAVENLKNI FSVPEIVRET QDLIEQGALL
160 170 180 190 200
QAHRKLMDLE CSRDGLMYEQ YRMDSGNTRD MTLIHGYFGS TQGLSDELAK
210 220 230 240 250
QLWMVLQRSL VTVRRDPTLL VSVVRIIERE EKIDRRILDR KKQTGFVPPG
260 270 280 290 300
RPKNWKEKMF TILERTVTTR IEGTQADTRE SDKMWLVRHL EIIRKYVLDD
310 320 330 340 350
LIVAKNLMVQ CFPPHYEIFK NLLNMYHQAL STRMQDLASE DLEANEIVSL
360 370 380 390 400
LTWVLNTYTS TEMMRNVELA PEVDVGTLEP LLSPHVVSEL LDTYMSTLTS
410 420 430 440 450
NIIAWLRKAL ETDKKDWVKE TEPEADQDGY YQTTLPAIVF QMFEQNLQVA
460 470 480 490 500
AQISEDLKTK VLVLCLQQMN SFLSRYKDEA QLYKEEHLRN RQHPHCYVQY
510 520 530 540 550
MIAIINNCQT FKESIVSLKR KYLKNEVEEG VSPSQPSMDG ILDAIAKEGC
560 570 580 590 600
SGLLEEVFLD LEQHLNELMT KKWLLGSNAV DIICVTVEDY FNDFAKIKKP
610 620 630 640 650
YKKRMTAEAH RRVVVEYLRA VMQKRISFRS PEERKEGAEK MVREAEQLRF
660 670 680 690 700
LFRKLASGFG EDVDGYCDTI VAVAEVIKLT DPSLLYLEVS TLVSKYPDIR
710 720 730 740 750
DDHIGALLAV RGDASRDMKQ TIMETLEQGP AQASPSYVPL FKDIVVPSLN

VAKLLK
Length:756
Mass (Da):86,845
Last modified:October 25, 2002 - v2
Checksum:i5B34ED2D5DE91168
GO
Isoform 2 (identifier: O60645-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     360-474: Missing.

Note: No experimental confirmation available.
Show »
Length:641
Mass (Da):73,797
Checksum:i783F7B6EE7F43A3E
GO
Isoform 3 (identifier: O60645-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.

Show »
Length:745
Mass (Da):85,567
Checksum:i81D03FB3351A995D
GO

Sequence cautioni

The sequence BAB84912 differs from that shown. Reason: Frameshift at positions 1 and 563.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0462351 – 11Missing in isoform 3. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_001482360 – 474Missing in isoform 2. 1 PublicationAdd BLAST115

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU727644 mRNA. Translation: ADU87645.1.
AK074086 mRNA. Translation: BAB84912.1. Frameshift.
AC010442 Genomic DNA. No translation available.
CH471235 Genomic DNA. Translation: EAW51000.1.
BC001511 mRNA. Translation: AAH01511.2.
BC019304 mRNA. Translation: AAH19304.1.
BC064569 mRNA. Translation: AAH64569.1.
AF055006 mRNA. Translation: AAC09358.1.
CCDSiCCDS54830.1. [O60645-3]
RefSeqiNP_009208.2. NM_007277.4. [O60645-3]
XP_016864492.1. XM_017009003.1. [O60645-3]
XP_016864493.1. XM_017009004.1. [O60645-3]
UniGeneiHs.481464.

Genome annotation databases

EnsembliENST00000315013; ENSP00000323377; ENSG00000180104. [O60645-3]
ENST00000512944; ENSP00000425587; ENSG00000180104. [O60645-3]
GeneIDi11336.
KEGGihsa:11336.
UCSCiuc003jba.4. human. [O60645-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU727644 mRNA. Translation: ADU87645.1.
AK074086 mRNA. Translation: BAB84912.1. Frameshift.
AC010442 Genomic DNA. No translation available.
CH471235 Genomic DNA. Translation: EAW51000.1.
BC001511 mRNA. Translation: AAH01511.2.
BC019304 mRNA. Translation: AAH19304.1.
BC064569 mRNA. Translation: AAH64569.1.
AF055006 mRNA. Translation: AAC09358.1.
CCDSiCCDS54830.1. [O60645-3]
RefSeqiNP_009208.2. NM_007277.4. [O60645-3]
XP_016864492.1. XM_017009003.1. [O60645-3]
XP_016864493.1. XM_017009004.1. [O60645-3]
UniGeneiHs.481464.

3D structure databases

ProteinModelPortaliO60645.
SMRiO60645.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116464. 48 interactors.
IntActiO60645. 20 interactors.
MINTiMINT-2796954.
STRINGi9606.ENSP00000323377.

PTM databases

iPTMnetiO60645.
PhosphoSitePlusiO60645.

Polymorphism and mutation databases

BioMutaiEXOC3.

Proteomic databases

EPDiO60645.
MaxQBiO60645.
PaxDbiO60645.
PeptideAtlasiO60645.
PRIDEiO60645.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315013; ENSP00000323377; ENSG00000180104. [O60645-3]
ENST00000512944; ENSP00000425587; ENSG00000180104. [O60645-3]
GeneIDi11336.
KEGGihsa:11336.
UCSCiuc003jba.4. human. [O60645-1]

Organism-specific databases

CTDi11336.
DisGeNETi11336.
GeneCardsiEXOC3.
HGNCiHGNC:30378. EXOC3.
HPAiCAB017459.
HPA037880.
HPA037881.
MIMi608186. gene.
neXtProtiNX_O60645.
OpenTargetsiENSG00000180104.
PharmGKBiPA134869816.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2286. Eukaryota.
COG5173. LUCA.
GeneTreeiENSGT00530000062934.
HOGENOMiHOG000043095.
HOVERGENiHBG034187.
InParanoidiO60645.
KOiK06110.
OMAiIDVNKDW.
OrthoDBiEOG091G02T2.
PhylomeDBiO60645.
TreeFamiTF314979.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180104-MONOMER.
ReactomeiR-HSA-1445148. Translocation of GLUT4 to the plasma membrane.
R-HSA-264876. Insulin processing.
R-HSA-5620916. VxPx cargo-targeting to cilium.

Miscellaneous databases

GeneWikiiEXOC3.
GenomeRNAii11336.
PROiO60645.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180104.
CleanExiHS_EXOC3.
ExpressionAtlasiO60645. baseline and differential.
GenevisibleiO60645. HS.

Family and domain databases

InterProiIPR010326. EXOC3/Sec6.
[Graphical view]
PANTHERiPTHR21292. PTHR21292. 1 hit.
PfamiPF06046. Sec6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEXOC3_HUMAN
AccessioniPrimary (citable) accession number: O60645
Secondary accession number(s): Q6P2E8
, Q8TEN6, Q8WUW0, Q96DI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 25, 2002
Last modified: November 30, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.