Reviewed, UniProtKB/Swiss-Prot O60645 (EXOC3_HUMAN)

Names and origin

Protein names

Recommended name:
    Exocyst complex component 3
Alternative name(s):
    Exocyst complex component Sec6

Gene names

Name:	EXOC3
Synonyms:	SEC6, SEC6L1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	756 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane.
Subunit structure	The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 By similarity.
Sequence similarities	Belongs to the SEC6 family.
Sequence caution	The sequence BAB84912.1 differs from that shown. Reason: Frameshift at positions 1 and 563.

Ontologies

Keywords
Biological process	Exocytosis Protein transport Transport
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Gene Ontology (GO)
Biological process	exocytosis Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O60645-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O60645-2)

The sequence of this isoform differs from the canonical sequence as follows:
     360-474: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 756	756	Exocyst complex component 3		PRO_0000118925
Regions
	Coiled coil	35 – 63	29	Potential
	Coiled coil	632 – 648	17	Potential
Natural variations
	Alternative sequence	360 – 474	115	Missing in isoform 2.		VSP_001482

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 25, 2002. Version 2. Checksum: 5B34ED2D5DE91168	FASTA	756	86,845
	10 20 30 40 50 60 MQCEDSTSFF TMKETDREAV ATAVQRVAGM LQRPDQLDKV EQYRRREARK KASVEARLKA 70 80 90 100 110 120 AIQSQLDGVR TGLSQLHNAL NDVKDIQQSL ADVSKDWRQS INTIESLKDV KDAVVQHSQL 130 140 150 160 170 180 AAAVENLKNI FSVPEIVRET QDLIEQGALL QAHRKLMDLE CSRDGLMYEQ YRMDSGNTRD 190 200 210 220 230 240 MTLIHGYFGS TQGLSDELAK QLWMVLQRSL VTVRRDPTLL VSVVRIIERE EKIDRRILDR 250 260 270 280 290 300 KKQTGFVPPG RPKNWKEKMF TILERTVTTR IEGTQADTRE SDKMWLVRHL EIIRKYVLDD 310 320 330 340 350 360 LIVAKNLMVQ CFPPHYEIFK NLLNMYHQAL STRMQDLASE DLEANEIVSL LTWVLNTYTS 370 380 390 400 410 420 TEMMRNVELA PEVDVGTLEP LLSPHVVSEL LDTYMSTLTS NIIAWLRKAL ETDKKDWVKE 430 440 450 460 470 480 TEPEADQDGY YQTTLPAIVF QMFEQNLQVA AQISEDLKTK VLVLCLQQMN SFLSRYKDEA 490 500 510 520 530 540 QLYKEEHLRN RQHPHCYVQY MIAIINNCQT FKESIVSLKR KYLKNEVEEG VSPSQPSMDG 550 560 570 580 590 600 ILDAIAKEGC SGLLEEVFLD LEQHLNELMT KKWLLGSNAV DIICVTVEDY FNDFAKIKKP 610 620 630 640 650 660 YKKRMTAEAH RRVVVEYLRA VMQKRISFRS PEERKEGAEK MVREAEQLRF LFRKLASGFG 670 680 690 700 710 720 EDVDGYCDTI VAVAEVIKLT DPSLLYLEVS TLVSKYPDIR DDHIGALLAV RGDASRDMKQ 730 740 750 TIMETLEQGP AQASPSYVPL FKDIVVPSLN VAKLLK
	Isoform 2. Checksum: 783F7B6EE7F43A3E	FASTA	641	73,797
	10 20 30 40 50 60 MQCEDSTSFF TMKETDREAV ATAVQRVAGM LQRPDQLDKV EQYRRREARK KASVEARLKA 70 80 90 100 110 120 AIQSQLDGVR TGLSQLHNAL NDVKDIQQSL ADVSKDWRQS INTIESLKDV KDAVVQHSQL 130 140 150 160 170 180 AAAVENLKNI FSVPEIVRET QDLIEQGALL QAHRKLMDLE CSRDGLMYEQ YRMDSGNTRD 190 200 210 220 230 240 MTLIHGYFGS TQGLSDELAK QLWMVLQRSL VTVRRDPTLL VSVVRIIERE EKIDRRILDR 250 260 270 280 290 300 KKQTGFVPPG RPKNWKEKMF TILERTVTTR IEGTQADTRE SDKMWLVRHL EIIRKYVLDD 310 320 330 340 350 360 LIVAKNLMVQ CFPPHYEIFK NLLNMYHQAL STRMQDLASE DLEANEIVSL LTWVLNTYTR 370 380 390 400 410 420 YKDEAQLYKE EHLRNRQHPH CYVQYMIAII NNCQTFKESI VSLKRKYLKN EVEEGVSPSQ 430 440 450 460 470 480 PSMDGILDAI AKEGCSGLLE EVFLDLEQHL NELMTKKWLL GSNAVDIICV TVEDYFNDFA 490 500 510 520 530 540 KIKKPYKKRM TAEAHRRVVV EYLRAVMQKR ISFRSPEERK EGAEKMVREA EQLRFLFRKL 550 560 570 580 590 600 ASGFGEDVDG YCDTIVAVAE VIKLTDPSLL YLEVSTLVSK YPDIRDDHIG ALLAVRGDAS 610 620 630 640 RDMKQTIMET LEQGPAQASP SYVPLFKDIV VPSLNVAKLL K

References

[1]	"Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones." Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O. DNA Res. 10:49-57(2003) [PubMed: 12693554] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Spleen.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 109-756 (ISOFORM 1). Tissue: Colon and Lung.
[3]	Yu W., Gibbs R.A. Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 286-756 (ISOFORM 1). Tissue: Brain.
[4]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK074086 mRNA. Translation: BAB84912.1. Frameshift. BC001511 mRNA. Translation: AAH01511.2. BC019304 mRNA. Translation: AAH19304.1. AF055006 mRNA. Translation: AAC09358.1.
IPI	IPI00157734. IPI00219954.
UniGene	Hs.646923
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	O60645.
Genome annotation databases
Ensembl	ENSG00000180104. Homo sapiens. [Contig view]
Organism-specific databases
GeneCards	GC05P000497.
HGNC	HGNC:30378. EXOC3.
HPA	CAB017459.
MIM	608186. gene.
PharmGKB	PA134869816.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O60645.
HOVERGEN	O60645.
Enzyme and pathway databases
Pathway_Interaction_DB	arf6_traffickingpathway. Arf6 trafficking events. insulin_pathway. Insulin Pathway.
Gene expression databases
ArrayExpress	O60645.
Bgee	O60645.
CleanEx	HS_EXOC3.
GermOnline	ENSG00000180104. Homo sapiens.
Family and domain databases
InterPro	IPR010326. Sec6. [Graphical view]
PANTHER	PTHR21292. Sec6. 1 hit.
Pfam	PF06046. Sec6. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

EXOC3_HUMAN

Accession

Primary (citable) accession number: O60645
Secondary accession number(s): Q8TEN6, Q8WUW0, Q96DI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2002
Last sequence update:	October 25, 2002
Last modified:	April 14, 2009
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)