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O60645

- EXOC3_HUMAN

UniProt

O60645 - EXOC3_HUMAN

Protein

Exocyst complex component 3

Gene

EXOC3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (25 Oct 2002)
      Previous versions | rss
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    Functioni

    Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. exocytosis Source: UniProtKB-KW
    3. membrane organization Source: Reactome
    4. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Exocytosis, Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_147867. Translocation of GLUT4 to the plasma membrane.
    REACT_15550. Insulin processing.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Exocyst complex component 3
    Alternative name(s):
    Exocyst complex component Sec6
    Gene namesi
    Name:EXOC3
    Synonyms:SEC6, SEC6L1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:30378. EXOC3.

    Subcellular locationi

    GO - Cellular componenti

    1. exocyst Source: InterPro
    2. secretory granule membrane Source: Reactome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134869816.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 756756Exocyst complex component 3PRO_0000118925Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei39 – 391N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiO60645.
    PaxDbiO60645.
    PRIDEiO60645.

    PTM databases

    PhosphoSiteiO60645.

    Expressioni

    Tissue specificityi

    Expressed in epididymis (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiO60645.
    BgeeiO60645.
    CleanExiHS_EXOC3.
    GenevestigatoriO60645.

    Organism-specific databases

    HPAiCAB017459.
    HPA037880.
    HPA037881.

    Interactioni

    Subunit structurei

    The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with EXOC3L1 By similarity. Interacts with BIRC6/bruce. Interacts with MYRIP By similarity.By similarity

    Protein-protein interaction databases

    BioGridi116464. 17 interactions.
    IntActiO60645. 6 interactions.
    MINTiMINT-2796954.
    STRINGi9606.ENSP00000323377.

    Structurei

    3D structure databases

    ProteinModelPortaliO60645.
    SMRiO60645. Positions 390-724.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili35 – 6329Sequence AnalysisAdd
    BLAST
    Coiled coili632 – 64817Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SEC6 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5173.
    HOGENOMiHOG000043095.
    HOVERGENiHBG034187.
    InParanoidiO60645.
    KOiK06110.
    OMAiNIRDDAM.
    OrthoDBiEOG7X9G69.
    PhylomeDBiO60645.
    TreeFamiTF314979.

    Family and domain databases

    InterProiIPR010326. Sec6.
    [Graphical view]
    PANTHERiPTHR21292. PTHR21292. 1 hit.
    PfamiPF06046. Sec6. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O60645-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQCEDSTSFF TMKETDREAV ATAVQRVAGM LQRPDQLDKV EQYRRREARK    50
    KASVEARLKA AIQSQLDGVR TGLSQLHNAL NDVKDIQQSL ADVSKDWRQS 100
    INTIESLKDV KDAVVQHSQL AAAVENLKNI FSVPEIVRET QDLIEQGALL 150
    QAHRKLMDLE CSRDGLMYEQ YRMDSGNTRD MTLIHGYFGS TQGLSDELAK 200
    QLWMVLQRSL VTVRRDPTLL VSVVRIIERE EKIDRRILDR KKQTGFVPPG 250
    RPKNWKEKMF TILERTVTTR IEGTQADTRE SDKMWLVRHL EIIRKYVLDD 300
    LIVAKNLMVQ CFPPHYEIFK NLLNMYHQAL STRMQDLASE DLEANEIVSL 350
    LTWVLNTYTS TEMMRNVELA PEVDVGTLEP LLSPHVVSEL LDTYMSTLTS 400
    NIIAWLRKAL ETDKKDWVKE TEPEADQDGY YQTTLPAIVF QMFEQNLQVA 450
    AQISEDLKTK VLVLCLQQMN SFLSRYKDEA QLYKEEHLRN RQHPHCYVQY 500
    MIAIINNCQT FKESIVSLKR KYLKNEVEEG VSPSQPSMDG ILDAIAKEGC 550
    SGLLEEVFLD LEQHLNELMT KKWLLGSNAV DIICVTVEDY FNDFAKIKKP 600
    YKKRMTAEAH RRVVVEYLRA VMQKRISFRS PEERKEGAEK MVREAEQLRF 650
    LFRKLASGFG EDVDGYCDTI VAVAEVIKLT DPSLLYLEVS TLVSKYPDIR 700
    DDHIGALLAV RGDASRDMKQ TIMETLEQGP AQASPSYVPL FKDIVVPSLN 750
    VAKLLK 756
    Length:756
    Mass (Da):86,845
    Last modified:October 25, 2002 - v2
    Checksum:i5B34ED2D5DE91168
    GO
    Isoform 2 (identifier: O60645-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         360-474: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:641
    Mass (Da):73,797
    Checksum:i783F7B6EE7F43A3E
    GO
    Isoform 3 (identifier: O60645-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-11: Missing.

    Show »
    Length:745
    Mass (Da):85,567
    Checksum:i81D03FB3351A995D
    GO

    Sequence cautioni

    The sequence BAB84912.1 differs from that shown. Reason: Frameshift at positions 1 and 563.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1111Missing in isoform 3. 2 PublicationsVSP_046235Add
    BLAST
    Alternative sequencei360 – 474115Missing in isoform 2. 1 PublicationVSP_001482Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GU727644 mRNA. Translation: ADU87645.1.
    AK074086 mRNA. Translation: BAB84912.1. Frameshift.
    AC010442 Genomic DNA. No translation available.
    CH471235 Genomic DNA. Translation: EAW51000.1.
    BC001511 mRNA. Translation: AAH01511.2.
    BC019304 mRNA. Translation: AAH19304.1.
    BC064569 mRNA. Translation: AAH64569.1.
    AF055006 mRNA. Translation: AAC09358.1.
    CCDSiCCDS54830.1. [O60645-3]
    RefSeqiNP_009208.2. NM_007277.4. [O60645-3]
    XP_005248295.1. XM_005248238.1. [O60645-3]
    UniGeneiHs.481464.

    Genome annotation databases

    EnsembliENST00000315013; ENSP00000323377; ENSG00000180104. [O60645-3]
    ENST00000512944; ENSP00000425587; ENSG00000180104. [O60645-3]
    GeneIDi11336.
    KEGGihsa:11336.
    UCSCiuc003jba.3. human. [O60645-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GU727644 mRNA. Translation: ADU87645.1 .
    AK074086 mRNA. Translation: BAB84912.1 . Frameshift.
    AC010442 Genomic DNA. No translation available.
    CH471235 Genomic DNA. Translation: EAW51000.1 .
    BC001511 mRNA. Translation: AAH01511.2 .
    BC019304 mRNA. Translation: AAH19304.1 .
    BC064569 mRNA. Translation: AAH64569.1 .
    AF055006 mRNA. Translation: AAC09358.1 .
    CCDSi CCDS54830.1. [O60645-3 ]
    RefSeqi NP_009208.2. NM_007277.4. [O60645-3 ]
    XP_005248295.1. XM_005248238.1. [O60645-3 ]
    UniGenei Hs.481464.

    3D structure databases

    ProteinModelPortali O60645.
    SMRi O60645. Positions 390-724.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116464. 17 interactions.
    IntActi O60645. 6 interactions.
    MINTi MINT-2796954.
    STRINGi 9606.ENSP00000323377.

    PTM databases

    PhosphoSitei O60645.

    Proteomic databases

    MaxQBi O60645.
    PaxDbi O60645.
    PRIDEi O60645.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000315013 ; ENSP00000323377 ; ENSG00000180104 . [O60645-3 ]
    ENST00000512944 ; ENSP00000425587 ; ENSG00000180104 . [O60645-3 ]
    GeneIDi 11336.
    KEGGi hsa:11336.
    UCSCi uc003jba.3. human. [O60645-1 ]

    Organism-specific databases

    CTDi 11336.
    GeneCardsi GC05P000443.
    HGNCi HGNC:30378. EXOC3.
    HPAi CAB017459.
    HPA037880.
    HPA037881.
    MIMi 608186. gene.
    neXtProti NX_O60645.
    PharmGKBi PA134869816.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5173.
    HOGENOMi HOG000043095.
    HOVERGENi HBG034187.
    InParanoidi O60645.
    KOi K06110.
    OMAi NIRDDAM.
    OrthoDBi EOG7X9G69.
    PhylomeDBi O60645.
    TreeFami TF314979.

    Enzyme and pathway databases

    Reactomei REACT_147867. Translocation of GLUT4 to the plasma membrane.
    REACT_15550. Insulin processing.

    Miscellaneous databases

    GeneWikii EXOC3.
    GenomeRNAii 11336.
    NextBioi 43071.
    PROi O60645.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60645.
    Bgeei O60645.
    CleanExi HS_EXOC3.
    Genevestigatori O60645.

    Family and domain databases

    InterProi IPR010326. Sec6.
    [Graphical view ]
    PANTHERi PTHR21292. PTHR21292. 1 hit.
    Pfami PF06046. Sec6. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins."
      Li J., Liu F., Wang H., Liu X., Liu J., Li N., Wan F., Wang W., Zhang C., Jin S., Liu J., Zhu P., Liu Y.
      Mol. Cell. Proteomics 9:2517-2528(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
      Tissue: Epididymis.
    2. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
      Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
      DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Spleen.
    3. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 109-756 (ISOFORM 1/3).
      Tissue: Colon, Lung and Ovary.
    6. Yu W., Gibbs R.A.
      Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 286-756 (ISOFORM 1/3).
      Tissue: Brain.
    7. "Final stages of cytokinesis and midbody ring formation are controlled by BRUCE."
      Pohl C., Jentsch S.
      Cell 132:832-845(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BIRC6/BRUCE.
    8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-39, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiEXOC3_HUMAN
    AccessioniPrimary (citable) accession number: O60645
    Secondary accession number(s): Q6P2E8
    , Q8TEN6, Q8WUW0, Q96DI4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2002
    Last sequence update: October 25, 2002
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3