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Protein

Tetraspanin-3

Gene

TSPAN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140391-MONOMER.

Protein family/group databases

TCDBi8.A.40.1.16. the tetraspanin (tetraspanin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-3
Short name:
Tspan-3
Alternative name(s):
Tetraspanin TM4-A
Transmembrane 4 superfamily member 8
Gene namesi
Name:TSPAN3
Synonyms:TM4SF8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:17752. TSPAN3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 50ExtracellularSequence analysisAdd BLAST18
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Topological domaini72 – 85CytoplasmicSequence analysisAdd BLAST14
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 212ExtracellularSequence analysisAdd BLAST106
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Topological domaini234 – 253CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000140391.
PharmGKBiPA134913500.

Polymorphism and mutation databases

BioMutaiTSPAN3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192391 – 253Tetraspanin-3Add BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi127N-linked (GlcNAc...)Sequence analysis1
Glycosylationi152N-linked (GlcNAc...)Sequence analysis1
Glycosylationi167N-linked (GlcNAc...)Sequence analysis1
Glycosylationi183N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO60637.
PaxDbiO60637.
PeptideAtlasiO60637.
PRIDEiO60637.

PTM databases

iPTMnetiO60637.
PhosphoSitePlusiO60637.
SwissPalmiO60637.
UniCarbKBiO60637.

Expressioni

Gene expression databases

BgeeiENSG00000140391.
CleanExiHS_TSPAN3.
ExpressionAtlasiO60637. baseline and differential.
GenevisibleiO60637. HS.

Organism-specific databases

HPAiHPA015996.

Interactioni

Subunit structurei

Interacts with claudin-11/CLDN11 and integrins.By similarity

Protein-protein interaction databases

BioGridi115406. 52 interactors.
IntActiO60637. 3 interactors.
MINTiMINT-1465751.
STRINGi9606.ENSP00000267970.

Structurei

3D structure databases

ProteinModelPortaliO60637.
SMRiO60637.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230654.
HOVERGENiHBG104967.
InParanoidiO60637.
KOiK17293.
OMAiDLYSEGC.
OrthoDBiEOG091G0INM.
PhylomeDBiO60637.
TreeFamiTF316345.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60637-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQCGITSSK TVLVFLNLIF WGAAGILCYV GAYVFITYDD YDHFFEDVYT
60 70 80 90 100
LIPAVVIIAV GALLFIIGLI GCCATIRESR CGLATFVIIL LLVFVTEVVV
110 120 130 140 150
VVLGYVYRAK VENEVDRSIQ KVYKTYNGTN PDAASRAIDY VQRQLHCCGI
160 170 180 190 200
HNYSDWENTD WFKETKNQSV PLSCCRETAS NCNGSLAHPS DLYAEGCEAL
210 220 230 240 250
VVKKLQEIMM HVIWAALAFA AIQLLGMLCA CIVLCRRSRD PAYELLITGG

TYA
Length:253
Mass (Da):28,018
Last modified:August 1, 1998 - v1
Checksum:iE074A4CD57229EC6
GO
Isoform 2 (identifier: O60637-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-110: Missing.

Note: No experimental confirmation available.
Show »
Length:228
Mass (Da):25,183
Checksum:iF44F7EAD2803A735
GO
Isoform 3 (identifier: O60637-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-85: Missing.

Note: No experimental confirmation available.
Show »
Length:189
Mass (Da):21,184
Checksum:iAD906FFB870A639D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85Missing in AAH00704 (PubMed:15489334).Curated1
Sequence conflicti236R → G in BAA91613 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04351922 – 85Missing in isoform 3. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_04267986 – 110Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054840 mRNA. Translation: AAC69716.1.
AF133423 mRNA. Translation: AAF08362.1.
AK001326 mRNA. Translation: BAA91627.1.
AK001305 mRNA. Translation: BAA91613.1.
AK001310 mRNA. Translation: BAA91615.1.
AK075336 mRNA. Translation: BAG52114.1.
AK075482 mRNA. Translation: BAG52152.1.
AK298157 mRNA. Translation: BAG60431.1.
AC090181 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99209.1.
CH471136 Genomic DNA. Translation: EAW99210.1.
CH471136 Genomic DNA. Translation: EAW99211.1.
BC000704 mRNA. Translation: AAH00704.1.
BC004280 mRNA. Translation: AAH04280.1.
BC009248 mRNA. Translation: AAH09248.1.
BC011206 mRNA. Translation: AAH11206.1.
CCDSiCCDS10292.1. [O60637-1]
CCDS10293.1. [O60637-2]
CCDS53963.1. [O60637-3]
PIRiA59264.
RefSeqiNP_001161884.1. NM_001168412.1. [O60637-3]
NP_005715.1. NM_005724.5. [O60637-1]
NP_944492.1. NM_198902.2. [O60637-2]
UniGeneiHs.744863.

Genome annotation databases

EnsembliENST00000267970; ENSP00000267970; ENSG00000140391. [O60637-1]
ENST00000346495; ENSP00000341329; ENSG00000140391. [O60637-2]
ENST00000424443; ENSP00000407243; ENSG00000140391. [O60637-3]
GeneIDi10099.
KEGGihsa:10099.
UCSCiuc002bcj.4. human. [O60637-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054840 mRNA. Translation: AAC69716.1.
AF133423 mRNA. Translation: AAF08362.1.
AK001326 mRNA. Translation: BAA91627.1.
AK001305 mRNA. Translation: BAA91613.1.
AK001310 mRNA. Translation: BAA91615.1.
AK075336 mRNA. Translation: BAG52114.1.
AK075482 mRNA. Translation: BAG52152.1.
AK298157 mRNA. Translation: BAG60431.1.
AC090181 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99209.1.
CH471136 Genomic DNA. Translation: EAW99210.1.
CH471136 Genomic DNA. Translation: EAW99211.1.
BC000704 mRNA. Translation: AAH00704.1.
BC004280 mRNA. Translation: AAH04280.1.
BC009248 mRNA. Translation: AAH09248.1.
BC011206 mRNA. Translation: AAH11206.1.
CCDSiCCDS10292.1. [O60637-1]
CCDS10293.1. [O60637-2]
CCDS53963.1. [O60637-3]
PIRiA59264.
RefSeqiNP_001161884.1. NM_001168412.1. [O60637-3]
NP_005715.1. NM_005724.5. [O60637-1]
NP_944492.1. NM_198902.2. [O60637-2]
UniGeneiHs.744863.

3D structure databases

ProteinModelPortaliO60637.
SMRiO60637.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115406. 52 interactors.
IntActiO60637. 3 interactors.
MINTiMINT-1465751.
STRINGi9606.ENSP00000267970.

Protein family/group databases

TCDBi8.A.40.1.16. the tetraspanin (tetraspanin) family.

PTM databases

iPTMnetiO60637.
PhosphoSitePlusiO60637.
SwissPalmiO60637.
UniCarbKBiO60637.

Polymorphism and mutation databases

BioMutaiTSPAN3.

Proteomic databases

MaxQBiO60637.
PaxDbiO60637.
PeptideAtlasiO60637.
PRIDEiO60637.

Protocols and materials databases

DNASUi10099.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267970; ENSP00000267970; ENSG00000140391. [O60637-1]
ENST00000346495; ENSP00000341329; ENSG00000140391. [O60637-2]
ENST00000424443; ENSP00000407243; ENSG00000140391. [O60637-3]
GeneIDi10099.
KEGGihsa:10099.
UCSCiuc002bcj.4. human. [O60637-1]

Organism-specific databases

CTDi10099.
GeneCardsiTSPAN3.
HGNCiHGNC:17752. TSPAN3.
HPAiHPA015996.
MIMi613134. gene.
neXtProtiNX_O60637.
OpenTargetsiENSG00000140391.
PharmGKBiPA134913500.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230654.
HOVERGENiHBG104967.
InParanoidiO60637.
KOiK17293.
OMAiDLYSEGC.
OrthoDBiEOG091G0INM.
PhylomeDBiO60637.
TreeFamiTF316345.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140391-MONOMER.

Miscellaneous databases

ChiTaRSiTSPAN3. human.
GeneWikiiTSPAN3.
GenomeRNAii10099.
PROiO60637.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140391.
CleanExiHS_TSPAN3.
ExpressionAtlasiO60637. baseline and differential.
GenevisibleiO60637. HS.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSN3_HUMAN
AccessioniPrimary (citable) accession number: O60637
Secondary accession number(s): A6NEH4
, B3KQQ2, B4DP19, Q9BW22, Q9NVX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.