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O60637

- TSN3_HUMAN

UniProt

O60637 - TSN3_HUMAN

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Protein
Tetraspanin-3
Gene
TSPAN3, TM4SF8
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-3
Short name:
Tspan-3
Alternative name(s):
Tetraspanin TM4-A
Transmembrane 4 superfamily member 8
Gene namesi
Name:TSPAN3
Synonyms:TM4SF8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:17752. TSPAN3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei12 – 3221Helical; Reviewed prediction
Add
BLAST
Topological domaini33 – 5018Extracellular Reviewed prediction
Add
BLAST
Transmembranei51 – 7121Helical; Reviewed prediction
Add
BLAST
Topological domaini72 – 8514Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei86 – 10621Helical; Reviewed prediction
Add
BLAST
Topological domaini107 – 212106Extracellular Reviewed prediction
Add
BLAST
Transmembranei213 – 23321Helical; Reviewed prediction
Add
BLAST
Topological domaini234 – 25320Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134913500.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253Tetraspanin-3
PRO_0000219239Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi127 – 1271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi152 – 1521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi167 – 1671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi183 – 1831N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO60637.
PaxDbiO60637.
PRIDEiO60637.

PTM databases

PhosphoSiteiO60637.

Expressioni

Gene expression databases

ArrayExpressiO60637.
BgeeiO60637.
CleanExiHS_TSPAN3.
GenevestigatoriO60637.

Organism-specific databases

HPAiHPA015996.

Interactioni

Subunit structurei

Interacts with claudin-11/CLDN11 and integrins By similarity.

Protein-protein interaction databases

BioGridi115406. 3 interactions.
IntActiO60637. 3 interactions.
MINTiMINT-1465751.
STRINGi9606.ENSP00000267970.

Structurei

3D structure databases

ProteinModelPortaliO60637.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG317438.
HOGENOMiHOG000230654.
HOVERGENiHBG104967.
InParanoidiO60637.
KOiK17293.
OMAiYVIWAAL.
OrthoDBiEOG7PGDRZ.
PhylomeDBiO60637.
TreeFamiTF316345.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O60637-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGQCGITSSK TVLVFLNLIF WGAAGILCYV GAYVFITYDD YDHFFEDVYT    50
LIPAVVIIAV GALLFIIGLI GCCATIRESR CGLATFVIIL LLVFVTEVVV 100
VVLGYVYRAK VENEVDRSIQ KVYKTYNGTN PDAASRAIDY VQRQLHCCGI 150
HNYSDWENTD WFKETKNQSV PLSCCRETAS NCNGSLAHPS DLYAEGCEAL 200
VVKKLQEIMM HVIWAALAFA AIQLLGMLCA CIVLCRRSRD PAYELLITGG 250
TYA 253
Length:253
Mass (Da):28,018
Last modified:August 1, 1998 - v1
Checksum:iE074A4CD57229EC6
GO
Isoform 2 (identifier: O60637-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-110: Missing.

Note: No experimental confirmation available.

Show »
Length:228
Mass (Da):25,183
Checksum:iF44F7EAD2803A735
GO
Isoform 3 (identifier: O60637-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-85: Missing.

Note: No experimental confirmation available.

Show »
Length:189
Mass (Da):21,184
Checksum:iAD906FFB870A639D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei22 – 8564Missing in isoform 3.
VSP_043519Add
BLAST
Alternative sequencei86 – 11025Missing in isoform 2.
VSP_042679Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851Missing in AAH00704. 1 Publication
Sequence conflicti236 – 2361R → G in BAA91613. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF054840 mRNA. Translation: AAC69716.1.
AF133423 mRNA. Translation: AAF08362.1.
AK001326 mRNA. Translation: BAA91627.1.
AK001305 mRNA. Translation: BAA91613.1.
AK001310 mRNA. Translation: BAA91615.1.
AK075336 mRNA. Translation: BAG52114.1.
AK075482 mRNA. Translation: BAG52152.1.
AK298157 mRNA. Translation: BAG60431.1.
AC090181 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99209.1.
CH471136 Genomic DNA. Translation: EAW99210.1.
CH471136 Genomic DNA. Translation: EAW99211.1.
BC000704 mRNA. Translation: AAH00704.1.
BC004280 mRNA. Translation: AAH04280.1.
BC009248 mRNA. Translation: AAH09248.1.
BC011206 mRNA. Translation: AAH11206.1.
CCDSiCCDS10292.1. [O60637-1]
CCDS10293.1. [O60637-2]
CCDS53963.1. [O60637-3]
PIRiA59264.
RefSeqiNP_001161884.1. NM_001168412.1. [O60637-3]
NP_005715.1. NM_005724.5. [O60637-1]
NP_944492.1. NM_198902.2. [O60637-2]
UniGeneiHs.744863.

Genome annotation databases

EnsembliENST00000267970; ENSP00000267970; ENSG00000140391. [O60637-1]
ENST00000346495; ENSP00000341329; ENSG00000140391. [O60637-2]
ENST00000424443; ENSP00000407243; ENSG00000140391. [O60637-3]
GeneIDi10099.
KEGGihsa:10099.
UCSCiuc002bcj.3. human. [O60637-1]
uc002bck.3. human. [O60637-2]
uc010ump.2. human. [O60637-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF054840 mRNA. Translation: AAC69716.1 .
AF133423 mRNA. Translation: AAF08362.1 .
AK001326 mRNA. Translation: BAA91627.1 .
AK001305 mRNA. Translation: BAA91613.1 .
AK001310 mRNA. Translation: BAA91615.1 .
AK075336 mRNA. Translation: BAG52114.1 .
AK075482 mRNA. Translation: BAG52152.1 .
AK298157 mRNA. Translation: BAG60431.1 .
AC090181 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99209.1 .
CH471136 Genomic DNA. Translation: EAW99210.1 .
CH471136 Genomic DNA. Translation: EAW99211.1 .
BC000704 mRNA. Translation: AAH00704.1 .
BC004280 mRNA. Translation: AAH04280.1 .
BC009248 mRNA. Translation: AAH09248.1 .
BC011206 mRNA. Translation: AAH11206.1 .
CCDSi CCDS10292.1. [O60637-1 ]
CCDS10293.1. [O60637-2 ]
CCDS53963.1. [O60637-3 ]
PIRi A59264.
RefSeqi NP_001161884.1. NM_001168412.1. [O60637-3 ]
NP_005715.1. NM_005724.5. [O60637-1 ]
NP_944492.1. NM_198902.2. [O60637-2 ]
UniGenei Hs.744863.

3D structure databases

ProteinModelPortali O60637.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115406. 3 interactions.
IntActi O60637. 3 interactions.
MINTi MINT-1465751.
STRINGi 9606.ENSP00000267970.

PTM databases

PhosphoSitei O60637.

Proteomic databases

MaxQBi O60637.
PaxDbi O60637.
PRIDEi O60637.

Protocols and materials databases

DNASUi 10099.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000267970 ; ENSP00000267970 ; ENSG00000140391 . [O60637-1 ]
ENST00000346495 ; ENSP00000341329 ; ENSG00000140391 . [O60637-2 ]
ENST00000424443 ; ENSP00000407243 ; ENSG00000140391 . [O60637-3 ]
GeneIDi 10099.
KEGGi hsa:10099.
UCSCi uc002bcj.3. human. [O60637-1 ]
uc002bck.3. human. [O60637-2 ]
uc010ump.2. human. [O60637-3 ]

Organism-specific databases

CTDi 10099.
GeneCardsi GC15M077336.
HGNCi HGNC:17752. TSPAN3.
HPAi HPA015996.
MIMi 613134. gene.
neXtProti NX_O60637.
PharmGKBi PA134913500.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG317438.
HOGENOMi HOG000230654.
HOVERGENi HBG104967.
InParanoidi O60637.
KOi K17293.
OMAi YVIWAAL.
OrthoDBi EOG7PGDRZ.
PhylomeDBi O60637.
TreeFami TF316345.

Miscellaneous databases

ChiTaRSi TSPAN3. human.
GeneWikii TSPAN3.
GenomeRNAii 10099.
NextBioi 38199.
PROi O60637.
SOURCEi Search...

Gene expression databases

ArrayExpressi O60637.
Bgeei O60637.
CleanExi HS_TSPAN3.
Genevestigatori O60637.

Family and domain databases

InterProi IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view ]
Pfami PF00335. Tetraspannin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002419. Tetraspanin. 1 hit.
PRINTSi PR00259. TMFOUR.
SUPFAMi SSF48652. SSF48652. 1 hit.
PROSITEi PS00421. TM4_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequences and expression of six new members of the tetraspanin/TM4SF family."
    Todd S.C., Doctor V.S., Levy S.
    Biochim. Biophys. Acta 1399:101-104(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The molecular characterization of four tetraspanins."
    Puls K.L., Ni J., Liu D., Morahan G., Wright M.D.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
  4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Ovary.
  5. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cervix, Colon, Muscle and Skin.

Entry informationi

Entry nameiTSN3_HUMAN
AccessioniPrimary (citable) accession number: O60637
Secondary accession number(s): A6NEH4
, B3KQQ2, B4DP19, Q9BW22, Q9NVX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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