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O60637

- TSN3_HUMAN

UniProt

O60637 - TSN3_HUMAN

Protein

Tetraspanin-3

Gene

TSPAN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tetraspanin-3
    Short name:
    Tspan-3
    Alternative name(s):
    Tetraspanin TM4-A
    Transmembrane 4 superfamily member 8
    Gene namesi
    Name:TSPAN3
    Synonyms:TM4SF8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:17752. TSPAN3.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134913500.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 253253Tetraspanin-3PRO_0000219239Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiO60637.
    PaxDbiO60637.
    PRIDEiO60637.

    PTM databases

    PhosphoSiteiO60637.

    Expressioni

    Gene expression databases

    ArrayExpressiO60637.
    BgeeiO60637.
    CleanExiHS_TSPAN3.
    GenevestigatoriO60637.

    Organism-specific databases

    HPAiHPA015996.

    Interactioni

    Subunit structurei

    Interacts with claudin-11/CLDN11 and integrins.By similarity

    Protein-protein interaction databases

    BioGridi115406. 3 interactions.
    IntActiO60637. 3 interactions.
    MINTiMINT-1465751.
    STRINGi9606.ENSP00000267970.

    Structurei

    3D structure databases

    ProteinModelPortaliO60637.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1111CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini33 – 5018ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini72 – 8514CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini107 – 212106ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini234 – 25320CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei51 – 7121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei86 – 10621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei213 – 23321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetraspanin (TM4SF) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG317438.
    HOGENOMiHOG000230654.
    HOVERGENiHBG104967.
    InParanoidiO60637.
    KOiK17293.
    OMAiYVIWAAL.
    OrthoDBiEOG7PGDRZ.
    PhylomeDBiO60637.
    TreeFamiTF316345.

    Family and domain databases

    InterProiIPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002419. Tetraspanin. 1 hit.
    PRINTSiPR00259. TMFOUR.
    SUPFAMiSSF48652. SSF48652. 1 hit.
    PROSITEiPS00421. TM4_1. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O60637-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGQCGITSSK TVLVFLNLIF WGAAGILCYV GAYVFITYDD YDHFFEDVYT    50
    LIPAVVIIAV GALLFIIGLI GCCATIRESR CGLATFVIIL LLVFVTEVVV 100
    VVLGYVYRAK VENEVDRSIQ KVYKTYNGTN PDAASRAIDY VQRQLHCCGI 150
    HNYSDWENTD WFKETKNQSV PLSCCRETAS NCNGSLAHPS DLYAEGCEAL 200
    VVKKLQEIMM HVIWAALAFA AIQLLGMLCA CIVLCRRSRD PAYELLITGG 250
    TYA 253
    Length:253
    Mass (Da):28,018
    Last modified:August 1, 1998 - v1
    Checksum:iE074A4CD57229EC6
    GO
    Isoform 2 (identifier: O60637-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         86-110: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:228
    Mass (Da):25,183
    Checksum:iF44F7EAD2803A735
    GO
    Isoform 3 (identifier: O60637-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         22-85: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:189
    Mass (Da):21,184
    Checksum:iAD906FFB870A639D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti85 – 851Missing in AAH00704. (PubMed:15489334)Curated
    Sequence conflicti236 – 2361R → G in BAA91613. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei22 – 8564Missing in isoform 3. 1 PublicationVSP_043519Add
    BLAST
    Alternative sequencei86 – 11025Missing in isoform 2. 1 PublicationVSP_042679Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF054840 mRNA. Translation: AAC69716.1.
    AF133423 mRNA. Translation: AAF08362.1.
    AK001326 mRNA. Translation: BAA91627.1.
    AK001305 mRNA. Translation: BAA91613.1.
    AK001310 mRNA. Translation: BAA91615.1.
    AK075336 mRNA. Translation: BAG52114.1.
    AK075482 mRNA. Translation: BAG52152.1.
    AK298157 mRNA. Translation: BAG60431.1.
    AC090181 Genomic DNA. No translation available.
    CH471136 Genomic DNA. Translation: EAW99209.1.
    CH471136 Genomic DNA. Translation: EAW99210.1.
    CH471136 Genomic DNA. Translation: EAW99211.1.
    BC000704 mRNA. Translation: AAH00704.1.
    BC004280 mRNA. Translation: AAH04280.1.
    BC009248 mRNA. Translation: AAH09248.1.
    BC011206 mRNA. Translation: AAH11206.1.
    CCDSiCCDS10292.1. [O60637-1]
    CCDS10293.1. [O60637-2]
    CCDS53963.1. [O60637-3]
    PIRiA59264.
    RefSeqiNP_001161884.1. NM_001168412.1. [O60637-3]
    NP_005715.1. NM_005724.5. [O60637-1]
    NP_944492.1. NM_198902.2. [O60637-2]
    UniGeneiHs.744863.

    Genome annotation databases

    EnsembliENST00000267970; ENSP00000267970; ENSG00000140391. [O60637-1]
    ENST00000346495; ENSP00000341329; ENSG00000140391. [O60637-2]
    ENST00000424443; ENSP00000407243; ENSG00000140391. [O60637-3]
    GeneIDi10099.
    KEGGihsa:10099.
    UCSCiuc002bcj.3. human. [O60637-1]
    uc002bck.3. human. [O60637-2]
    uc010ump.2. human. [O60637-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF054840 mRNA. Translation: AAC69716.1 .
    AF133423 mRNA. Translation: AAF08362.1 .
    AK001326 mRNA. Translation: BAA91627.1 .
    AK001305 mRNA. Translation: BAA91613.1 .
    AK001310 mRNA. Translation: BAA91615.1 .
    AK075336 mRNA. Translation: BAG52114.1 .
    AK075482 mRNA. Translation: BAG52152.1 .
    AK298157 mRNA. Translation: BAG60431.1 .
    AC090181 Genomic DNA. No translation available.
    CH471136 Genomic DNA. Translation: EAW99209.1 .
    CH471136 Genomic DNA. Translation: EAW99210.1 .
    CH471136 Genomic DNA. Translation: EAW99211.1 .
    BC000704 mRNA. Translation: AAH00704.1 .
    BC004280 mRNA. Translation: AAH04280.1 .
    BC009248 mRNA. Translation: AAH09248.1 .
    BC011206 mRNA. Translation: AAH11206.1 .
    CCDSi CCDS10292.1. [O60637-1 ]
    CCDS10293.1. [O60637-2 ]
    CCDS53963.1. [O60637-3 ]
    PIRi A59264.
    RefSeqi NP_001161884.1. NM_001168412.1. [O60637-3 ]
    NP_005715.1. NM_005724.5. [O60637-1 ]
    NP_944492.1. NM_198902.2. [O60637-2 ]
    UniGenei Hs.744863.

    3D structure databases

    ProteinModelPortali O60637.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115406. 3 interactions.
    IntActi O60637. 3 interactions.
    MINTi MINT-1465751.
    STRINGi 9606.ENSP00000267970.

    PTM databases

    PhosphoSitei O60637.

    Proteomic databases

    MaxQBi O60637.
    PaxDbi O60637.
    PRIDEi O60637.

    Protocols and materials databases

    DNASUi 10099.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000267970 ; ENSP00000267970 ; ENSG00000140391 . [O60637-1 ]
    ENST00000346495 ; ENSP00000341329 ; ENSG00000140391 . [O60637-2 ]
    ENST00000424443 ; ENSP00000407243 ; ENSG00000140391 . [O60637-3 ]
    GeneIDi 10099.
    KEGGi hsa:10099.
    UCSCi uc002bcj.3. human. [O60637-1 ]
    uc002bck.3. human. [O60637-2 ]
    uc010ump.2. human. [O60637-3 ]

    Organism-specific databases

    CTDi 10099.
    GeneCardsi GC15M077336.
    HGNCi HGNC:17752. TSPAN3.
    HPAi HPA015996.
    MIMi 613134. gene.
    neXtProti NX_O60637.
    PharmGKBi PA134913500.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG317438.
    HOGENOMi HOG000230654.
    HOVERGENi HBG104967.
    InParanoidi O60637.
    KOi K17293.
    OMAi YVIWAAL.
    OrthoDBi EOG7PGDRZ.
    PhylomeDBi O60637.
    TreeFami TF316345.

    Miscellaneous databases

    ChiTaRSi TSPAN3. human.
    GeneWikii TSPAN3.
    GenomeRNAii 10099.
    NextBioi 38199.
    PROi O60637.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60637.
    Bgeei O60637.
    CleanExi HS_TSPAN3.
    Genevestigatori O60637.

    Family and domain databases

    InterProi IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002419. Tetraspanin. 1 hit.
    PRINTSi PR00259. TMFOUR.
    SUPFAMi SSF48652. SSF48652. 1 hit.
    PROSITEi PS00421. TM4_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequences and expression of six new members of the tetraspanin/TM4SF family."
      Todd S.C., Doctor V.S., Levy S.
      Biochim. Biophys. Acta 1399:101-104(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The molecular characterization of four tetraspanins."
      Puls K.L., Ni J., Liu D., Morahan G., Wright M.D.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Ovary.
    5. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Cervix, Colon, Muscle and Skin.

    Entry informationi

    Entry nameiTSN3_HUMAN
    AccessioniPrimary (citable) accession number: O60637
    Secondary accession number(s): A6NEH4
    , B3KQQ2, B4DP19, Q9BW22, Q9NVX9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3