O60636 (TSN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tetraspanin-2
Short name=Tspan-2

Alternative name(s):
Tetraspan NET-3

Gene names

Name:

TSPAN2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Probable.
Sequence similarities	Belongs to the tetraspanin (TM4SF) family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	brain development Inferred from electronic annotation. Source: Compara
Cellular_component	integral to membrane Traceable author statement Ref.1. Source: ProtInc myelin sheath Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 221	221	Tetraspanin-2		PRO_0000219236
Regions
	Topological domain	1 – 13	13	Cytoplasmic Potential
	Transmembrane	14 – 34	21	Helical; Potential
	Topological domain	35 – 54	20	Extracellular Potential
	Transmembrane	55 – 75	21	Helical; Potential
	Topological domain	76 – 90	15	Cytoplasmic Potential
	Transmembrane	91 – 111	21	Helical; Potential
	Topological domain	112 – 188	77	Extracellular Potential
	Transmembrane	189 – 209	21	Helical; Potential
	Topological domain	210 – 221	12	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	139	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	118	1	R → L. Corresponds to variant rs9659602 [ dbSNP | Ensembl ].		VAR_052328
Experimental info
	Sequence conflict	80 – 82	3	AMR → PCW in AAC69715. Ref.1
	Sequence conflict	146 – 148	3	HST → PLQH in AAC69715. Ref.1
	Sequence conflict	170	1	G → R in AAC69715. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O60636 [UniParc]. Last modified September 19, 2002. Version 2. Checksum: 8973B46795901802	FASTA	221	24,148
	10 20 30 40 50 60 MGRFRGGLRC IKYLLLGFNL LFWLAGSAVI AFGLWFRFGG AIKELSSEDK SPEYFYVGLY 70 80 90 100 110 120 VLVGAGALMM AVGFFGCCGA MRESQCVLGS FFTCLLVIFA AEVTTGVFAF IGKGVAIRHV 130 140 150 160 170 180 QTMYEEAYND YLKDRGKGNG TLITFHSTFQ CCGKESSEQV QPTCPKELLG HKNCIDEIET 190 200 210 220 IISVKLQLIG IVGIGIAGLT IFGMIFSMVL CCAIRNSRDV I

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequences and expression of six new members of the tetraspanin/TM4SF family." Todd S.C., Doctor V.S., Levy S. Biochim. Biophys. Acta 1399:101-104(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF054839 mRNA. Translation: AAC69715.1. AL109660 Genomic DNA. Translation: CAI22271.1. BC021675 mRNA. Translation: AAH21675.1.
IPI	IPI00030938.
PIR	A59263.
RefSeq	NP_005716.2. NM_005725.4.
UniGene	Hs.310458.
3D structure databases
ProteinModelPortal	O60636.
SMR	O60636. Positions 110-184.
ModBase	Search...
Protein-protein interaction databases
IntAct	O60636. 1 interaction.
STRING	9606.ENSP00000358529.
Proteomic databases
PaxDb	O60636.
PRIDE	O60636.
Protocols and materials databases
DNASU	10100.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000369516; ENSP00000358529; ENSG00000134198.
GeneID	10100.
KEGG	hsa:10100.
UCSC	uc001eft.3. human.
Organism-specific databases
CTD	10100.
GeneCards	GC01M115590.
HGNC	HGNC:20659. TSPAN2.
HPA	HPA015640.
MIM	613133. gene.
neXtProt	NX_O60636.
PharmGKB	PA134938787.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG293348.
HOGENOM	HOG000230651.
HOVERGEN	HBG002324.
InParanoid	O60636.
OMA	YMGLYVL.
OrthoDB	EOG4DZ1W7.
PhylomeDB	O60636.
Gene expression databases
ArrayExpress	O60636.
Bgee	O60636.
CleanEx	HS_TSPAN2.
Genevestigator	O60636.
GermOnline	ENSG00000134198. Homo sapiens.
Family and domain databases
InterPro	IPR000301. Tetraspanin. IPR018499. Tetraspanin/Peripherin. IPR018503. Tetraspanin_CS. IPR008952. Tetraspanin_EC2. [Graphical view]
Pfam	PF00335. Tetraspannin. 1 hit. [Graphical view]
PIRSF	PIRSF002419. Tetraspanin. 1 hit.
PRINTS	PR00259. TMFOUR.
SUPFAM	SSF48652. Tetraspanin. 1 hit.
PROSITE	PS00421. TM4_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	10100.
NextBio	38205.
SOURCE	Search...

Entry information

Entry name

TSN2_HUMAN

Accession

Primary (citable) accession number: O60636
Secondary accession number(s): Q5TET2, Q8WU05

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	September 19, 2002
Last modified:	April 3, 2013
This is version 102 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.