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O60636

- TSN2_HUMAN

UniProt

O60636 - TSN2_HUMAN

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Protein

Tetraspanin-2

Gene

TSPAN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.By similarity

GO - Biological processi

  1. astrocyte development Source: Ensembl
  2. axon development Source: Ensembl
  3. brain development Source: Ensembl
  4. inflammatory response Source: Ensembl
  5. microglia development Source: Ensembl
  6. myelination Source: Ensembl
  7. oligodendrocyte differentiation Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-2
Short name:
Tspan-2
Alternative name(s):
Tetraspan NET-3
Gene namesi
Name:TSPAN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:20659. TSPAN2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: ProtInc
  2. myelin sheath Source: Ensembl
  3. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134938787.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Tetraspanin-2PRO_0000219236Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO60636.
PaxDbiO60636.
PRIDEiO60636.

Expressioni

Gene expression databases

BgeeiO60636.
CleanExiHS_TSPAN2.
ExpressionAtlasiO60636. baseline and differential.
GenevestigatoriO60636.

Organism-specific databases

HPAiHPA015640.

Interactioni

Protein-protein interaction databases

BioGridi115407. 1 interaction.
IntActiO60636. 1 interaction.
STRINGi9606.ENSP00000358529.

Structurei

3D structure databases

ProteinModelPortaliO60636.
SMRiO60636. Positions 110-184.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini35 – 5420ExtracellularSequence AnalysisAdd
BLAST
Topological domaini76 – 9015CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini112 – 18877ExtracellularSequence AnalysisAdd
BLAST
Topological domaini210 – 22112CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3421HelicalSequence AnalysisAdd
BLAST
Transmembranei55 – 7521HelicalSequence AnalysisAdd
BLAST
Transmembranei91 – 11121HelicalSequence AnalysisAdd
BLAST
Transmembranei189 – 20921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293348.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiO60636.
KOiK17354.
OMAiWFRFGGT.
OrthoDBiEOG72JWHF.
PhylomeDBiO60636.
TreeFamiTF352895.

Family and domain databases

Gene3Di1.10.1450.10. 1 hit.
InterProiIPR028977. CD81_LEL.
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O60636-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRFRGGLRC IKYLLLGFNL LFWLAGSAVI AFGLWFRFGG AIKELSSEDK
60 70 80 90 100
SPEYFYVGLY VLVGAGALMM AVGFFGCCGA MRESQCVLGS FFTCLLVIFA
110 120 130 140 150
AEVTTGVFAF IGKGVAIRHV QTMYEEAYND YLKDRGKGNG TLITFHSTFQ
160 170 180 190 200
CCGKESSEQV QPTCPKELLG HKNCIDEIET IISVKLQLIG IVGIGIAGLT
210 220
IFGMIFSMVL CCAIRNSRDV I
Length:221
Mass (Da):24,148
Last modified:September 19, 2002 - v2
Checksum:i8973B46795901802
GO
Isoform 2 (identifier: O60636-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     173-200: Missing.

Show »
Length:193
Mass (Da):21,269
Checksum:i342623BF9BCCD1AD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti80 – 823AMR → PCW in AAC69715. (PubMed:9714763)Curated
Sequence conflicti146 – 1483HST → PLQH in AAC69715. (PubMed:9714763)Curated
Sequence conflicti170 – 1701G → R in AAC69715. (PubMed:9714763)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti118 – 1181R → L.
Corresponds to variant rs9659602 [ dbSNP | Ensembl ].
VAR_052328

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei173 – 20028Missing in isoform 2. 1 PublicationVSP_047734Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF054839 mRNA. Translation: AAC69715.1.
GU971730 mRNA. Translation: ADF80915.1.
AL109660 Genomic DNA. Translation: CAI22271.1.
BC021675 mRNA. Translation: AAH21675.1.
CCDSiCCDS881.1. [O60636-1]
PIRiA59263.
RefSeqiNP_005716.2. NM_005725.4. [O60636-1]
XP_005270397.1. XM_005270340.2. [O60636-2]
UniGeneiHs.310458.

Genome annotation databases

EnsembliENST00000369516; ENSP00000358529; ENSG00000134198. [O60636-1]
GeneIDi10100.
KEGGihsa:10100.
UCSCiuc001eft.3. human. [O60636-1]
uc021osc.1. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF054839 mRNA. Translation: AAC69715.1 .
GU971730 mRNA. Translation: ADF80915.1 .
AL109660 Genomic DNA. Translation: CAI22271.1 .
BC021675 mRNA. Translation: AAH21675.1 .
CCDSi CCDS881.1. [O60636-1 ]
PIRi A59263.
RefSeqi NP_005716.2. NM_005725.4. [O60636-1 ]
XP_005270397.1. XM_005270340.2. [O60636-2 ]
UniGenei Hs.310458.

3D structure databases

ProteinModelPortali O60636.
SMRi O60636. Positions 110-184.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115407. 1 interaction.
IntActi O60636. 1 interaction.
STRINGi 9606.ENSP00000358529.

Proteomic databases

MaxQBi O60636.
PaxDbi O60636.
PRIDEi O60636.

Protocols and materials databases

DNASUi 10100.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369516 ; ENSP00000358529 ; ENSG00000134198 . [O60636-1 ]
GeneIDi 10100.
KEGGi hsa:10100.
UCSCi uc001eft.3. human. [O60636-1 ]
uc021osc.1. human.

Organism-specific databases

CTDi 10100.
GeneCardsi GC01M115590.
HGNCi HGNC:20659. TSPAN2.
HPAi HPA015640.
MIMi 613133. gene.
neXtProti NX_O60636.
PharmGKBi PA134938787.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG293348.
GeneTreei ENSGT00760000118983.
HOGENOMi HOG000230651.
HOVERGENi HBG002324.
InParanoidi O60636.
KOi K17354.
OMAi WFRFGGT.
OrthoDBi EOG72JWHF.
PhylomeDBi O60636.
TreeFami TF352895.

Miscellaneous databases

GeneWikii TSPAN2.
GenomeRNAii 10100.
NextBioi 35492714.
PROi O60636.
SOURCEi Search...

Gene expression databases

Bgeei O60636.
CleanExi HS_TSPAN2.
ExpressionAtlasi O60636. baseline and differential.
Genevestigatori O60636.

Family and domain databases

Gene3Di 1.10.1450.10. 1 hit.
InterProi IPR028977. CD81_LEL.
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view ]
Pfami PF00335. Tetraspannin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002419. Tetraspanin. 1 hit.
PRINTSi PR00259. TMFOUR.
SUPFAMi SSF48652. SSF48652. 1 hit.
PROSITEi PS00421. TM4_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequences and expression of six new members of the tetraspanin/TM4SF family."
    Todd S.C., Doctor V.S., Levy S.
    Biochim. Biophys. Acta 1399:101-104(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cloning of a TSPAN2 splice isoform."
    Ryu H.-W., Park J.
    Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.

Entry informationi

Entry nameiTSN2_HUMAN
AccessioniPrimary (citable) accession number: O60636
Secondary accession number(s): D6PTH4, Q5TET2, Q8WU05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 19, 2002
Last modified: October 29, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3