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O60636 (TSN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tetraspanin-2

Short name=Tspan-2
Alternative name(s):
Tetraspan NET-3
Gene names
Name:TSPAN2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length221 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Sequence similarities

Belongs to the tetraspanin (TM4SF) family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbrain development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintegral component of membrane

Traceable author statement Ref.1. Source: ProtInc

myelin sheath

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O60636-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O60636-2)

The sequence of this isoform differs from the canonical sequence as follows:
     173-200: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 221221Tetraspanin-2
PRO_0000219236

Regions

Topological domain1 – 1313Cytoplasmic Potential
Transmembrane14 – 3421Helical; Potential
Topological domain35 – 5420Extracellular Potential
Transmembrane55 – 7521Helical; Potential
Topological domain76 – 9015Cytoplasmic Potential
Transmembrane91 – 11121Helical; Potential
Topological domain112 – 18877Extracellular Potential
Transmembrane189 – 20921Helical; Potential
Topological domain210 – 22112Cytoplasmic Potential

Amino acid modifications

Glycosylation1391N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence173 – 20028Missing in isoform 2.
VSP_047734
Natural variant1181R → L.
Corresponds to variant rs9659602 [ dbSNP | Ensembl ].
VAR_052328

Experimental info

Sequence conflict80 – 823AMR → PCW in AAC69715. Ref.1
Sequence conflict146 – 1483HST → PLQH in AAC69715. Ref.1
Sequence conflict1701G → R in AAC69715. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 19, 2002. Version 2.
Checksum: 8973B46795901802

FASTA22124,148
        10         20         30         40         50         60 
MGRFRGGLRC IKYLLLGFNL LFWLAGSAVI AFGLWFRFGG AIKELSSEDK SPEYFYVGLY 

        70         80         90        100        110        120 
VLVGAGALMM AVGFFGCCGA MRESQCVLGS FFTCLLVIFA AEVTTGVFAF IGKGVAIRHV 

       130        140        150        160        170        180 
QTMYEEAYND YLKDRGKGNG TLITFHSTFQ CCGKESSEQV QPTCPKELLG HKNCIDEIET 

       190        200        210        220 
IISVKLQLIG IVGIGIAGLT IFGMIFSMVL CCAIRNSRDV I 

« Hide

Isoform 2 [UniParc].

Checksum: 342623BF9BCCD1AD
Show »

FASTA19321,269

References

« Hide 'large scale' references
[1]"Sequences and expression of six new members of the tetraspanin/TM4SF family."
Todd S.C., Doctor V.S., Levy S.
Biochim. Biophys. Acta 1399:101-104(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Cloning of a TSPAN2 splice isoform."
Ryu H.-W., Park J.
Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF054839 mRNA. Translation: AAC69715.1.
GU971730 mRNA. Translation: ADF80915.1.
AL109660 Genomic DNA. Translation: CAI22271.1.
BC021675 mRNA. Translation: AAH21675.1.
CCDSCCDS881.1. [O60636-1]
PIRA59263.
RefSeqNP_005716.2. NM_005725.4. [O60636-1]
XP_005270397.1. XM_005270340.2. [O60636-2]
UniGeneHs.310458.

3D structure databases

ProteinModelPortalO60636.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115407. 1 interaction.
IntActO60636. 1 interaction.
STRING9606.ENSP00000358529.

Proteomic databases

MaxQBO60636.
PaxDbO60636.
PRIDEO60636.

Protocols and materials databases

DNASU10100.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000369514; ENSP00000358527; ENSG00000134198. [O60636-2]
ENST00000369516; ENSP00000358529; ENSG00000134198. [O60636-1]
GeneID10100.
KEGGhsa:10100.
UCSCuc001eft.3. human. [O60636-1]

Organism-specific databases

CTD10100.
GeneCardsGC01M115590.
HGNCHGNC:20659. TSPAN2.
HPAHPA015640.
MIM613133. gene.
neXtProtNX_O60636.
PharmGKBPA134938787.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG293348.
HOGENOMHOG000230651.
HOVERGENHBG002324.
InParanoidO60636.
KOK17354.
OMAWFRFGGT.
OrthoDBEOG72JWHF.
PhylomeDBO60636.
TreeFamTF352895.

Gene expression databases

ArrayExpressO60636.
BgeeO60636.
CleanExHS_TSPAN2.
GenevestigatorO60636.

Family and domain databases

Gene3D1.10.1450.10. 1 hit.
InterProIPR028977. CD81_LEL.
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFPIRSF002419. Tetraspanin. 1 hit.
PRINTSPR00259. TMFOUR.
SUPFAMSSF48652. SSF48652. 1 hit.
PROSITEPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTSPAN2.
GenomeRNAi10100.
NextBio35492714.
PROO60636.
SOURCESearch...

Entry information

Entry nameTSN2_HUMAN
AccessionPrimary (citable) accession number: O60636
Secondary accession number(s): D6PTH4, Q5TET2, Q8WU05
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 19, 2002
Last modified: July 9, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM