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Protein

Tetraspanin-2

Gene

TSPAN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134198-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-2
Short name:
Tspan-2
Alternative name(s):
Tetraspan NET-3
Gene namesi
Name:TSPAN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:20659. TSPAN2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 54ExtracellularSequence analysisAdd BLAST20
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Topological domaini76 – 90CytoplasmicSequence analysisAdd BLAST15
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 188ExtracellularSequence analysisAdd BLAST77
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 221CytoplasmicSequence analysisAdd BLAST12

GO - Cellular componenti

  • integral component of membrane Source: ProtInc
  • integral component of plasma membrane Source: GO_Central
  • myelin sheath Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10100.
OpenTargetsiENSG00000134198.
PharmGKBiPA134938787.

Polymorphism and mutation databases

BioMutaiTSPAN2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192361 – 221Tetraspanin-2Add BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi139N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO60636.
PaxDbiO60636.
PeptideAtlasiO60636.
PRIDEiO60636.

PTM databases

iPTMnetiO60636.
PhosphoSitePlusiO60636.

Expressioni

Gene expression databases

BgeeiENSG00000134198.
CleanExiHS_TSPAN2.
ExpressionAtlasiO60636. baseline and differential.
GenevisibleiO60636. HS.

Organism-specific databases

HPAiHPA015640.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GRB2P629936EBI-3914288,EBI-401755
PIK3R3Q925693EBI-3914288,EBI-79893

Protein-protein interaction databases

BioGridi115407. 22 interactors.
IntActiO60636. 5 interactors.
STRINGi9606.ENSP00000358529.

Structurei

3D structure databases

ProteinModelPortaliO60636.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiO60636.
KOiK17354.
OMAiYEEAYNS.
OrthoDBiEOG091G0K9H.
PhylomeDBiO60636.
TreeFamiTF352895.

Family and domain databases

Gene3Di1.10.1450.10. 1 hit.
InterProiIPR028977. CD81_LEL.
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60636-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRFRGGLRC IKYLLLGFNL LFWLAGSAVI AFGLWFRFGG AIKELSSEDK
60 70 80 90 100
SPEYFYVGLY VLVGAGALMM AVGFFGCCGA MRESQCVLGS FFTCLLVIFA
110 120 130 140 150
AEVTTGVFAF IGKGVAIRHV QTMYEEAYND YLKDRGKGNG TLITFHSTFQ
160 170 180 190 200
CCGKESSEQV QPTCPKELLG HKNCIDEIET IISVKLQLIG IVGIGIAGLT
210 220
IFGMIFSMVL CCAIRNSRDV I
Length:221
Mass (Da):24,148
Last modified:September 19, 2002 - v2
Checksum:i8973B46795901802
GO
Isoform 2 (identifier: O60636-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     173-200: Missing.

Show »
Length:193
Mass (Da):21,269
Checksum:i342623BF9BCCD1AD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80 – 82AMR → PCW in AAC69715 (PubMed:9714763).Curated3
Sequence conflicti146 – 148HST → PLQH in AAC69715 (PubMed:9714763).Curated3
Sequence conflicti170G → R in AAC69715 (PubMed:9714763).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052328118R → L.Corresponds to variant rs9659602dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047734173 – 200Missing in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054839 mRNA. Translation: AAC69715.1.
GU971730 mRNA. Translation: ADF80915.1.
AL109660 Genomic DNA. Translation: CAI22271.1.
BC021675 mRNA. Translation: AAH21675.1.
CCDSiCCDS881.1. [O60636-1]
PIRiA59263.
RefSeqiNP_001295245.1. NM_001308316.1. [O60636-2]
NP_005716.2. NM_005725.5. [O60636-1]
UniGeneiHs.310458.

Genome annotation databases

EnsembliENST00000369516; ENSP00000358529; ENSG00000134198. [O60636-1]
GeneIDi10100.
KEGGihsa:10100.
UCSCiuc001eft.5. human. [O60636-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054839 mRNA. Translation: AAC69715.1.
GU971730 mRNA. Translation: ADF80915.1.
AL109660 Genomic DNA. Translation: CAI22271.1.
BC021675 mRNA. Translation: AAH21675.1.
CCDSiCCDS881.1. [O60636-1]
PIRiA59263.
RefSeqiNP_001295245.1. NM_001308316.1. [O60636-2]
NP_005716.2. NM_005725.5. [O60636-1]
UniGeneiHs.310458.

3D structure databases

ProteinModelPortaliO60636.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115407. 22 interactors.
IntActiO60636. 5 interactors.
STRINGi9606.ENSP00000358529.

PTM databases

iPTMnetiO60636.
PhosphoSitePlusiO60636.

Polymorphism and mutation databases

BioMutaiTSPAN2.

Proteomic databases

MaxQBiO60636.
PaxDbiO60636.
PeptideAtlasiO60636.
PRIDEiO60636.

Protocols and materials databases

DNASUi10100.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369516; ENSP00000358529; ENSG00000134198. [O60636-1]
GeneIDi10100.
KEGGihsa:10100.
UCSCiuc001eft.5. human. [O60636-1]

Organism-specific databases

CTDi10100.
DisGeNETi10100.
GeneCardsiTSPAN2.
HGNCiHGNC:20659. TSPAN2.
HPAiHPA015640.
MIMi613133. gene.
neXtProtiNX_O60636.
OpenTargetsiENSG00000134198.
PharmGKBiPA134938787.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiO60636.
KOiK17354.
OMAiYEEAYNS.
OrthoDBiEOG091G0K9H.
PhylomeDBiO60636.
TreeFamiTF352895.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134198-MONOMER.

Miscellaneous databases

ChiTaRSiTSPAN2. human.
GeneWikiiTSPAN2.
GenomeRNAii10100.
PROiO60636.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134198.
CleanExiHS_TSPAN2.
ExpressionAtlasiO60636. baseline and differential.
GenevisibleiO60636. HS.

Family and domain databases

Gene3Di1.10.1450.10. 1 hit.
InterProiIPR028977. CD81_LEL.
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSN2_HUMAN
AccessioniPrimary (citable) accession number: O60636
Secondary accession number(s): D6PTH4, Q5TET2, Q8WU05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 19, 2002
Last modified: November 30, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.