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O60636

- TSN2_HUMAN

UniProt

O60636 - TSN2_HUMAN

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Protein
Tetraspanin-2
Gene
TSPAN2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath By similarity.

GO - Biological processi

  1. brain development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-2
Short name:
Tspan-2
Alternative name(s):
Tetraspan NET-3
Gene namesi
Name:TSPAN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:20659. TSPAN2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei14 – 3421Helical; Reviewed prediction
Add
BLAST
Topological domaini35 – 5420Extracellular Reviewed prediction
Add
BLAST
Transmembranei55 – 7521Helical; Reviewed prediction
Add
BLAST
Topological domaini76 – 9015Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei91 – 11121Helical; Reviewed prediction
Add
BLAST
Topological domaini112 – 18877Extracellular Reviewed prediction
Add
BLAST
Transmembranei189 – 20921Helical; Reviewed prediction
Add
BLAST
Topological domaini210 – 22112Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: ProtInc
  2. myelin sheath Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134938787.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Tetraspanin-2
PRO_0000219236Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi139 – 1391N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO60636.
PaxDbiO60636.
PRIDEiO60636.

Expressioni

Gene expression databases

ArrayExpressiO60636.
BgeeiO60636.
CleanExiHS_TSPAN2.
GenevestigatoriO60636.

Organism-specific databases

HPAiHPA015640.

Interactioni

Protein-protein interaction databases

BioGridi115407. 1 interaction.
IntActiO60636. 1 interaction.
STRINGi9606.ENSP00000358529.

Structurei

3D structure databases

ProteinModelPortaliO60636.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293348.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiO60636.
KOiK17354.
OMAiWFRFGGT.
OrthoDBiEOG72JWHF.
PhylomeDBiO60636.
TreeFamiTF352895.

Family and domain databases

Gene3Di1.10.1450.10. 1 hit.
InterProiIPR028977. CD81_LEL.
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O60636-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGRFRGGLRC IKYLLLGFNL LFWLAGSAVI AFGLWFRFGG AIKELSSEDK    50
SPEYFYVGLY VLVGAGALMM AVGFFGCCGA MRESQCVLGS FFTCLLVIFA 100
AEVTTGVFAF IGKGVAIRHV QTMYEEAYND YLKDRGKGNG TLITFHSTFQ 150
CCGKESSEQV QPTCPKELLG HKNCIDEIET IISVKLQLIG IVGIGIAGLT 200
IFGMIFSMVL CCAIRNSRDV I 221
Length:221
Mass (Da):24,148
Last modified:September 19, 2002 - v2
Checksum:i8973B46795901802
GO
Isoform 2 (identifier: O60636-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     173-200: Missing.

Show »
Length:193
Mass (Da):21,269
Checksum:i342623BF9BCCD1AD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti118 – 1181R → L.
Corresponds to variant rs9659602 [ dbSNP | Ensembl ].
VAR_052328

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei173 – 20028Missing in isoform 2.
VSP_047734Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti80 – 823AMR → PCW in AAC69715. 1 Publication
Sequence conflicti146 – 1483HST → PLQH in AAC69715. 1 Publication
Sequence conflicti170 – 1701G → R in AAC69715. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF054839 mRNA. Translation: AAC69715.1.
GU971730 mRNA. Translation: ADF80915.1.
AL109660 Genomic DNA. Translation: CAI22271.1.
BC021675 mRNA. Translation: AAH21675.1.
CCDSiCCDS881.1. [O60636-1]
PIRiA59263.
RefSeqiNP_005716.2. NM_005725.4. [O60636-1]
XP_005270397.1. XM_005270340.2. [O60636-2]
UniGeneiHs.310458.

Genome annotation databases

EnsembliENST00000369514; ENSP00000358527; ENSG00000134198. [O60636-2]
ENST00000369516; ENSP00000358529; ENSG00000134198. [O60636-1]
GeneIDi10100.
KEGGihsa:10100.
UCSCiuc001eft.3. human. [O60636-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF054839 mRNA. Translation: AAC69715.1 .
GU971730 mRNA. Translation: ADF80915.1 .
AL109660 Genomic DNA. Translation: CAI22271.1 .
BC021675 mRNA. Translation: AAH21675.1 .
CCDSi CCDS881.1. [O60636-1 ]
PIRi A59263.
RefSeqi NP_005716.2. NM_005725.4. [O60636-1 ]
XP_005270397.1. XM_005270340.2. [O60636-2 ]
UniGenei Hs.310458.

3D structure databases

ProteinModelPortali O60636.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115407. 1 interaction.
IntActi O60636. 1 interaction.
STRINGi 9606.ENSP00000358529.

Proteomic databases

MaxQBi O60636.
PaxDbi O60636.
PRIDEi O60636.

Protocols and materials databases

DNASUi 10100.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369514 ; ENSP00000358527 ; ENSG00000134198 . [O60636-2 ]
ENST00000369516 ; ENSP00000358529 ; ENSG00000134198 . [O60636-1 ]
GeneIDi 10100.
KEGGi hsa:10100.
UCSCi uc001eft.3. human. [O60636-1 ]

Organism-specific databases

CTDi 10100.
GeneCardsi GC01M115590.
HGNCi HGNC:20659. TSPAN2.
HPAi HPA015640.
MIMi 613133. gene.
neXtProti NX_O60636.
PharmGKBi PA134938787.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG293348.
HOGENOMi HOG000230651.
HOVERGENi HBG002324.
InParanoidi O60636.
KOi K17354.
OMAi WFRFGGT.
OrthoDBi EOG72JWHF.
PhylomeDBi O60636.
TreeFami TF352895.

Miscellaneous databases

GeneWikii TSPAN2.
GenomeRNAii 10100.
NextBioi 35492714.
PROi O60636.
SOURCEi Search...

Gene expression databases

ArrayExpressi O60636.
Bgeei O60636.
CleanExi HS_TSPAN2.
Genevestigatori O60636.

Family and domain databases

Gene3Di 1.10.1450.10. 1 hit.
InterProi IPR028977. CD81_LEL.
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view ]
Pfami PF00335. Tetraspannin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002419. Tetraspanin. 1 hit.
PRINTSi PR00259. TMFOUR.
SUPFAMi SSF48652. SSF48652. 1 hit.
PROSITEi PS00421. TM4_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequences and expression of six new members of the tetraspanin/TM4SF family."
    Todd S.C., Doctor V.S., Levy S.
    Biochim. Biophys. Acta 1399:101-104(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cloning of a TSPAN2 splice isoform."
    Ryu H.-W., Park J.
    Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.

Entry informationi

Entry nameiTSN2_HUMAN
AccessioniPrimary (citable) accession number: O60636
Secondary accession number(s): D6PTH4, Q5TET2, Q8WU05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 19, 2002
Last modified: July 9, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi