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O60636

- TSN2_HUMAN

UniProt

O60636 - TSN2_HUMAN

Protein

Tetraspanin-2

Gene

TSPAN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (19 Sep 2002)
      Previous versions | rss
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    Functioni

    May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.By similarity

    GO - Biological processi

    1. brain development Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tetraspanin-2
    Short name:
    Tspan-2
    Alternative name(s):
    Tetraspan NET-3
    Gene namesi
    Name:TSPAN2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:20659. TSPAN2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: ProtInc
    2. myelin sheath Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134938787.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 221221Tetraspanin-2PRO_0000219236Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiO60636.
    PaxDbiO60636.
    PRIDEiO60636.

    Expressioni

    Gene expression databases

    ArrayExpressiO60636.
    BgeeiO60636.
    CleanExiHS_TSPAN2.
    GenevestigatoriO60636.

    Organism-specific databases

    HPAiHPA015640.

    Interactioni

    Protein-protein interaction databases

    BioGridi115407. 1 interaction.
    IntActiO60636. 1 interaction.
    STRINGi9606.ENSP00000358529.

    Structurei

    3D structure databases

    ProteinModelPortaliO60636.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1313CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini35 – 5420ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini76 – 9015CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini112 – 18877ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini210 – 22112CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei91 – 11121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei189 – 20921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetraspanin (TM4SF) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG293348.
    HOGENOMiHOG000230651.
    HOVERGENiHBG002324.
    InParanoidiO60636.
    KOiK17354.
    OMAiWFRFGGT.
    OrthoDBiEOG72JWHF.
    PhylomeDBiO60636.
    TreeFamiTF352895.

    Family and domain databases

    Gene3Di1.10.1450.10. 1 hit.
    InterProiIPR028977. CD81_LEL.
    IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002419. Tetraspanin. 1 hit.
    PRINTSiPR00259. TMFOUR.
    SUPFAMiSSF48652. SSF48652. 1 hit.
    PROSITEiPS00421. TM4_1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O60636-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGRFRGGLRC IKYLLLGFNL LFWLAGSAVI AFGLWFRFGG AIKELSSEDK    50
    SPEYFYVGLY VLVGAGALMM AVGFFGCCGA MRESQCVLGS FFTCLLVIFA 100
    AEVTTGVFAF IGKGVAIRHV QTMYEEAYND YLKDRGKGNG TLITFHSTFQ 150
    CCGKESSEQV QPTCPKELLG HKNCIDEIET IISVKLQLIG IVGIGIAGLT 200
    IFGMIFSMVL CCAIRNSRDV I 221
    Length:221
    Mass (Da):24,148
    Last modified:September 19, 2002 - v2
    Checksum:i8973B46795901802
    GO
    Isoform 2 (identifier: O60636-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         173-200: Missing.

    Show »
    Length:193
    Mass (Da):21,269
    Checksum:i342623BF9BCCD1AD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti80 – 823AMR → PCW in AAC69715. (PubMed:9714763)Curated
    Sequence conflicti146 – 1483HST → PLQH in AAC69715. (PubMed:9714763)Curated
    Sequence conflicti170 – 1701G → R in AAC69715. (PubMed:9714763)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti118 – 1181R → L.
    Corresponds to variant rs9659602 [ dbSNP | Ensembl ].
    VAR_052328

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei173 – 20028Missing in isoform 2. 1 PublicationVSP_047734Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF054839 mRNA. Translation: AAC69715.1.
    GU971730 mRNA. Translation: ADF80915.1.
    AL109660 Genomic DNA. Translation: CAI22271.1.
    BC021675 mRNA. Translation: AAH21675.1.
    CCDSiCCDS881.1. [O60636-1]
    PIRiA59263.
    RefSeqiNP_005716.2. NM_005725.4. [O60636-1]
    XP_005270397.1. XM_005270340.2. [O60636-2]
    UniGeneiHs.310458.

    Genome annotation databases

    EnsembliENST00000369514; ENSP00000358527; ENSG00000134198. [O60636-2]
    ENST00000369516; ENSP00000358529; ENSG00000134198. [O60636-1]
    GeneIDi10100.
    KEGGihsa:10100.
    UCSCiuc001eft.3. human. [O60636-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF054839 mRNA. Translation: AAC69715.1 .
    GU971730 mRNA. Translation: ADF80915.1 .
    AL109660 Genomic DNA. Translation: CAI22271.1 .
    BC021675 mRNA. Translation: AAH21675.1 .
    CCDSi CCDS881.1. [O60636-1 ]
    PIRi A59263.
    RefSeqi NP_005716.2. NM_005725.4. [O60636-1 ]
    XP_005270397.1. XM_005270340.2. [O60636-2 ]
    UniGenei Hs.310458.

    3D structure databases

    ProteinModelPortali O60636.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115407. 1 interaction.
    IntActi O60636. 1 interaction.
    STRINGi 9606.ENSP00000358529.

    Proteomic databases

    MaxQBi O60636.
    PaxDbi O60636.
    PRIDEi O60636.

    Protocols and materials databases

    DNASUi 10100.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369514 ; ENSP00000358527 ; ENSG00000134198 . [O60636-2 ]
    ENST00000369516 ; ENSP00000358529 ; ENSG00000134198 . [O60636-1 ]
    GeneIDi 10100.
    KEGGi hsa:10100.
    UCSCi uc001eft.3. human. [O60636-1 ]

    Organism-specific databases

    CTDi 10100.
    GeneCardsi GC01M115590.
    HGNCi HGNC:20659. TSPAN2.
    HPAi HPA015640.
    MIMi 613133. gene.
    neXtProti NX_O60636.
    PharmGKBi PA134938787.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG293348.
    HOGENOMi HOG000230651.
    HOVERGENi HBG002324.
    InParanoidi O60636.
    KOi K17354.
    OMAi WFRFGGT.
    OrthoDBi EOG72JWHF.
    PhylomeDBi O60636.
    TreeFami TF352895.

    Miscellaneous databases

    GeneWikii TSPAN2.
    GenomeRNAii 10100.
    NextBioi 35492714.
    PROi O60636.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60636.
    Bgeei O60636.
    CleanExi HS_TSPAN2.
    Genevestigatori O60636.

    Family and domain databases

    Gene3Di 1.10.1450.10. 1 hit.
    InterProi IPR028977. CD81_LEL.
    IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002419. Tetraspanin. 1 hit.
    PRINTSi PR00259. TMFOUR.
    SUPFAMi SSF48652. SSF48652. 1 hit.
    PROSITEi PS00421. TM4_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequences and expression of six new members of the tetraspanin/TM4SF family."
      Todd S.C., Doctor V.S., Levy S.
      Biochim. Biophys. Acta 1399:101-104(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Cloning of a TSPAN2 splice isoform."
      Ryu H.-W., Park J.
      Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney.

    Entry informationi

    Entry nameiTSN2_HUMAN
    AccessioniPrimary (citable) accession number: O60636
    Secondary accession number(s): D6PTH4, Q5TET2, Q8WU05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: September 19, 2002
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3