Reviewed, UniProtKB/Swiss-Prot O60635 (TSN1_HUMAN)

Names and origin

Protein names

Recommended name:
    Tetraspanin-1
      Short name=Tspan-1
Alternative name(s):
    Tetraspan NET-1
    Tetraspanin TM4-C

Gene names

Name:

TSPAN1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane proteinProbable.
Sequence similarities	Belongs to the tetraspanin (TM4SF) family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
PTM	Glycoprotein
Gene Ontology (GO)
Cellular component	integral to membrane Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	Tetraspanin-1		PRO_0000219234
Regions
	Topological domain	1 – 11	11	Cytoplasmic Potential
	Transmembrane	12 – 32	21	Potential
	Topological domain	33 – 52	20	Extracellular Potential
	Transmembrane	53 – 73	21	Potential
	Topological domain	74 – 88	15	Cytoplasmic Potential
	Transmembrane	89 – 109	21	Potential
	Topological domain	110 – 211	102	Extracellular Potential
	Transmembrane	212 – 232	21	Potential
	Topological domain	233 – 241	9	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	141	1	N-linked (GlcNAc...) Potential
	Glycosylation	154	1	N-linked (GlcNAc...) Potential
	Glycosylation	178	1	N-linked (GlcNAc...) Potential
	Glycosylation	184	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	87	1	V → M: dbSNP rs2234268.		VAR_034573
Experimental info
	Sequence conflict	189	1	K → E in AAC69714. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O60635-1 [UniParc]. Last modified December 1, 2000. Version 2. Checksum: AF938AD7147CB884	FASTA	241	26,301
	10 20 30 40 50 60 MQCFSFIKTM MILFNLLIFL CGAALLAVGI WVSIDGASFL KIFGPLSSSA MQFVNVGYFL 70 80 90 100 110 120 IAAGVVVFAL GFLGCYGAKT ESKCALVTFF FILLLIFIAE VAAAVVALVY TTMAEHFLTL 130 140 150 160 170 180 LVVPAIKKDY GSQEDFTQVW NTTMKGLKCC GFTNYTDFED SPYFKENSAF PPFCCNDNVT 190 200 210 220 230 240 NTANETCTKQ KAHDQKVEGC FNQLLYDIRT NAVTVGGVAA GIGGLELAAM IVSMYLYCNL Q

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequences and expression of six new members of the tetraspanin/TM4SF family." Todd S.C., Doctor V.S., Levy S. Biochim. Biophys. Acta 1399:101-104(1998) [PubMed: 9714763] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"New tetraspans identified in the EST database." Rubinstein E., Serru V., Boucheix C. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The molecular characterization of four tetraspanins." Puls K.L., Ni J., Liu D., Morahan G., Wright M.D. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF054838 mRNA. Translation: AAC69714.1. AF065388 mRNA. Translation: AAC17119.1. AF133425 mRNA. Translation: AAF08364.1. BC007290 mRNA. Translation: AAH07290.1. BC013404 mRNA. Translation: AAH13404.1.
PIR	A59262.
RefSeq	NP_005718.2.
UniGene	Hs.38972
3D structure databases
ModBase	Search...
Proteomic databases
PeptideAtlas	O60635.
Genome annotation databases
Ensembl	ENSG00000117472. Homo sapiens. [Contig view]
GeneID	10103.
KEGG	hsa:10103.
Organism-specific databases
H-InvDB	HIX0000543.
HGNC	HGNC:20657. TSPAN1.
PharmGKB	PA134938100.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	O60635.
HOVERGEN	O60635.
Gene expression databases
ArrayExpress	O60635.
CleanEx	HS_TSPAN1.
GermOnline	ENSG00000117472. Homo sapiens.
Family and domain databases
InterPro	IPR000301. Transmem_4. [Graphical view]
Pfam	PF00335. Tetraspannin. 1 hit. [Graphical view]
PRINTS	PR00259. TMFOUR.
PROSITE	PS00421. TM4_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	38217.

Entry information

Entry name

TSN1_HUMAN

Accession

Primary (citable) accession number: O60635
Secondary accession number(s): O60745

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	November 4, 2008
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)