Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tetraspanin-1

Gene

TSPAN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • cell migration Source: UniProtKB
  • cell proliferation Source: UniProtKB
  • cell surface receptor signaling pathway Source: GO_Central
  • positive regulation of endocytosis Source: UniProtKB
  • protein stabilization Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-1
Short name:
Tspan-1
Alternative name(s):
Tetraspan NET-1
Tetraspanin TM4-C
Gene namesi
Name:TSPAN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:20657. TSPAN1.

Subcellular locationi

  • Lysosome membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111CytoplasmicSequence analysisAdd
BLAST
Transmembranei12 – 3221HelicalSequence analysisAdd
BLAST
Topological domaini33 – 5220ExtracellularSequence analysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence analysisAdd
BLAST
Topological domaini74 – 8815CytoplasmicSequence analysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence analysisAdd
BLAST
Topological domaini110 – 211102ExtracellularSequence analysisAdd
BLAST
Transmembranei212 – 23221HelicalSequence analysisAdd
BLAST
Topological domaini233 – 2419CytoplasmicSequence analysis

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • lysosomal membrane Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi141 – 1411N → A: Loss of glycosylation. 1 Publication
Mutagenesisi154 – 1541N → A: Loss of glycosylation. 1 Publication
Mutagenesisi178 – 1781N → A: Loss of glycosylation. 1 Publication
Mutagenesisi184 – 1841N → A: Loss of glycosylation. 1 Publication

Organism-specific databases

PharmGKBiPA134938100.

Polymorphism and mutation databases

BioMutaiTSPAN1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Tetraspanin-1PRO_0000219234Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi141 – 1411N-linked (GlcNAc...)1 Publication
Glycosylationi154 – 1541N-linked (GlcNAc...)1 Publication
Glycosylationi178 – 1781N-linked (GlcNAc...)1 Publication
Glycosylationi184 – 1841N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO60635.
PaxDbiO60635.
PeptideAtlasiO60635.
PRIDEiO60635.

Expressioni

Gene expression databases

BgeeiO60635.
CleanExiHS_TSPAN1.
GenevisibleiO60635. HS.

Organism-specific databases

HPAiHPA011909.

Interactioni

Protein-protein interaction databases

BioGridi115410. 1 interaction.
IntActiO60635. 1 interaction.
STRINGi9606.ENSP00000361072.

Structurei

3D structure databases

ProteinModelPortaliO60635.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG107159.
InParanoidiO60635.
KOiK17348.
OMAiFTQVWNT.
OrthoDBiEOG7CK38F.
PhylomeDBiO60635.
TreeFamiTF352892.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60635-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQCFSFIKTM MILFNLLIFL CGAALLAVGI WVSIDGASFL KIFGPLSSSA
60 70 80 90 100
MQFVNVGYFL IAAGVVVFAL GFLGCYGAKT ESKCALVTFF FILLLIFIAE
110 120 130 140 150
VAAAVVALVY TTMAEHFLTL LVVPAIKKDY GSQEDFTQVW NTTMKGLKCC
160 170 180 190 200
GFTNYTDFED SPYFKENSAF PPFCCNDNVT NTANETCTKQ KAHDQKVEGC
210 220 230 240
FNQLLYDIRT NAVTVGGVAA GIGGLELAAM IVSMYLYCNL Q
Length:241
Mass (Da):26,301
Last modified:December 1, 2000 - v2
Checksum:iAF938AD7147CB884
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti189 – 1891K → E in AAC69714 (PubMed:9714763).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti38 – 381S → F.
Corresponds to variant rs2234267 [ dbSNP | Ensembl ].
VAR_052327
Natural varianti87 – 871V → M.
Corresponds to variant rs2234268 [ dbSNP | Ensembl ].
VAR_034573

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054838 mRNA. Translation: AAC69714.1.
AF065388 mRNA. Translation: AAC17119.1.
AF133425 mRNA. Translation: AAF08364.1.
AK313774 mRNA. Translation: BAG36512.1.
AL672043 Genomic DNA. Translation: CAH72468.1.
CH471059 Genomic DNA. Translation: EAX06938.1.
CH471059 Genomic DNA. Translation: EAX06939.1.
CH471059 Genomic DNA. Translation: EAX06940.1.
BC007290 mRNA. Translation: AAH07290.1.
BC013404 mRNA. Translation: AAH13404.1.
CCDSiCCDS530.1.
PIRiA59262.
RefSeqiNP_005718.2. NM_005727.3.
UniGeneiHs.38972.

Genome annotation databases

EnsembliENST00000372003; ENSP00000361072; ENSG00000117472.
GeneIDi10103.
KEGGihsa:10103.
UCSCiuc001cpd.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054838 mRNA. Translation: AAC69714.1.
AF065388 mRNA. Translation: AAC17119.1.
AF133425 mRNA. Translation: AAF08364.1.
AK313774 mRNA. Translation: BAG36512.1.
AL672043 Genomic DNA. Translation: CAH72468.1.
CH471059 Genomic DNA. Translation: EAX06938.1.
CH471059 Genomic DNA. Translation: EAX06939.1.
CH471059 Genomic DNA. Translation: EAX06940.1.
BC007290 mRNA. Translation: AAH07290.1.
BC013404 mRNA. Translation: AAH13404.1.
CCDSiCCDS530.1.
PIRiA59262.
RefSeqiNP_005718.2. NM_005727.3.
UniGeneiHs.38972.

3D structure databases

ProteinModelPortaliO60635.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115410. 1 interaction.
IntActiO60635. 1 interaction.
STRINGi9606.ENSP00000361072.

Polymorphism and mutation databases

BioMutaiTSPAN1.

Proteomic databases

MaxQBiO60635.
PaxDbiO60635.
PeptideAtlasiO60635.
PRIDEiO60635.

Protocols and materials databases

DNASUi10103.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372003; ENSP00000361072; ENSG00000117472.
GeneIDi10103.
KEGGihsa:10103.
UCSCiuc001cpd.4. human.

Organism-specific databases

CTDi10103.
GeneCardsiTSPAN1.
HGNCiHGNC:20657. TSPAN1.
HPAiHPA011909.
MIMi613170. gene.
neXtProtiNX_O60635.
PharmGKBiPA134938100.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG107159.
InParanoidiO60635.
KOiK17348.
OMAiFTQVWNT.
OrthoDBiEOG7CK38F.
PhylomeDBiO60635.
TreeFamiTF352892.

Miscellaneous databases

GenomeRNAii10103.
NextBioi38217.
PROiO60635.
SOURCEiSearch...

Gene expression databases

BgeeiO60635.
CleanExiHS_TSPAN1.
GenevisibleiO60635. HS.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequences and expression of six new members of the tetraspanin/TM4SF family."
    Todd S.C., Doctor V.S., Levy S.
    Biochim. Biophys. Acta 1399:101-104(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "New tetraspans identified in the EST database."
    Rubinstein E., Serru V., Boucheix C.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The molecular characterization of four tetraspanins."
    Puls K.L., Ni J., Liu D., Morahan G., Wright M.D.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  8. "Glycosylation of tetraspanin Tspan-1 at four distinct sites promotes its transition through the endoplasmic reticulum."
    Scholz C.-J., Sauer G., Deissler H.
    Protein Pept. Lett. 16:1244-1248(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, GLYCOSYLATION AT ASN-141; ASN-154; ASN-178 AND ASN-184, MUTAGENESIS OF ASN-141; ASN-154; ASN-178 AND ASN-184.

Entry informationi

Entry nameiTSN1_HUMAN
AccessioniPrimary (citable) accession number: O60635
Secondary accession number(s): D3DQ14, O60745, Q5VST0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: March 16, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.