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Protein

Tetraspanin-1

Gene

TSPAN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • cell migration Source: UniProtKB
  • cell proliferation Source: UniProtKB
  • cell surface receptor signaling pathway Source: GO_Central
  • positive regulation of endocytosis Source: UniProtKB
  • protein stabilization Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-1
Short name:
Tspan-1
Alternative name(s):
Tetraspan NET-1
Tetraspanin TM4-C
Gene namesi
Name:TSPAN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117472.9.
HGNCiHGNC:20657. TSPAN1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 52ExtracellularSequence analysisAdd BLAST20
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 88CytoplasmicSequence analysisAdd BLAST15
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110 – 211ExtracellularSequence analysisAdd BLAST102
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Topological domaini233 – 241CytoplasmicSequence analysis9

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi141N → A: Loss of glycosylation. 1 Publication1
Mutagenesisi154N → A: Loss of glycosylation. 1 Publication1
Mutagenesisi178N → A: Loss of glycosylation. 1 Publication1
Mutagenesisi184N → A: Loss of glycosylation. 1 Publication1

Organism-specific databases

DisGeNETi10103.
OpenTargetsiENSG00000117472.
PharmGKBiPA134938100.

Polymorphism and mutation databases

BioMutaiTSPAN1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192341 – 241Tetraspanin-1Add BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi141N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi154N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi178N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi184N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO60635.
PaxDbiO60635.
PeptideAtlasiO60635.
PRIDEiO60635.

PTM databases

iPTMnetiO60635.
PhosphoSitePlusiO60635.

Expressioni

Gene expression databases

BgeeiENSG00000117472.
CleanExiHS_TSPAN1.
GenevisibleiO60635. HS.

Organism-specific databases

HPAiHPA011909.

Interactioni

Protein-protein interaction databases

BioGridi115410. 17 interactors.
IntActiO60635. 1 interactor.
STRINGi9606.ENSP00000361072.

Structurei

3D structure databases

ProteinModelPortaliO60635.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00880000137858.
HOGENOMiHOG000230651.
HOVERGENiHBG107159.
InParanoidiO60635.
KOiK17348.
OMAiCGFTNYT.
OrthoDBiEOG091G0PTV.
PhylomeDBiO60635.
TreeFamiTF352892.

Family and domain databases

Gene3Di1.10.1450.10. 1 hit.
InterProiView protein in InterPro
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
PfamiView protein in Pfam
PF00335. Tetraspannin. 1 hit.
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiView protein in PROSITE
PS00421. TM4_1. 1 hit.

Sequencei

Sequence statusi: Complete.

O60635-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQCFSFIKTM MILFNLLIFL CGAALLAVGI WVSIDGASFL KIFGPLSSSA
60 70 80 90 100
MQFVNVGYFL IAAGVVVFAL GFLGCYGAKT ESKCALVTFF FILLLIFIAE
110 120 130 140 150
VAAAVVALVY TTMAEHFLTL LVVPAIKKDY GSQEDFTQVW NTTMKGLKCC
160 170 180 190 200
GFTNYTDFED SPYFKENSAF PPFCCNDNVT NTANETCTKQ KAHDQKVEGC
210 220 230 240
FNQLLYDIRT NAVTVGGVAA GIGGLELAAM IVSMYLYCNL Q
Length:241
Mass (Da):26,301
Last modified:December 1, 2000 - v2
Checksum:iAF938AD7147CB884
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti189K → E in AAC69714 (PubMed:9714763).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05232738S → F. Corresponds to variant dbSNP:rs2234267Ensembl.1
Natural variantiVAR_03457387V → M. Corresponds to variant dbSNP:rs2234268Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054838 mRNA. Translation: AAC69714.1.
AF065388 mRNA. Translation: AAC17119.1.
AF133425 mRNA. Translation: AAF08364.1.
AK313774 mRNA. Translation: BAG36512.1.
AL672043 Genomic DNA. Translation: CAH72468.1.
CH471059 Genomic DNA. Translation: EAX06938.1.
CH471059 Genomic DNA. Translation: EAX06939.1.
CH471059 Genomic DNA. Translation: EAX06940.1.
BC007290 mRNA. Translation: AAH07290.1.
BC013404 mRNA. Translation: AAH13404.1.
CCDSiCCDS530.1.
PIRiA59262.
RefSeqiNP_005718.2. NM_005727.3.
UniGeneiHs.38972.

Genome annotation databases

EnsembliENST00000372003; ENSP00000361072; ENSG00000117472.
GeneIDi10103.
KEGGihsa:10103.
UCSCiuc001cpd.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Entry informationi

Entry nameiTSN1_HUMAN
AccessioniPrimary (citable) accession number: O60635
Secondary accession number(s): D3DQ14, O60745, Q5VST0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: September 27, 2017
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families