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Reviewed, UniProtKB/Swiss-Prot O60635 (TSN1_HUMAN)

Last modified November 4, 2008. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Tetraspanin-1
      Short name=Tspan-1
Alternative name(s):
    Tetraspan NET-1
    Tetraspanin TM4-C
Gene names
Name: TSPAN1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length241 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane proteinProbable.

Sequence similarities

Belongs to the tetraspanin (TM4SF) family.

Ontologies

Keywords

   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
   PTMGlycoprotein

Gene Ontology (GO)

   Cellular componentintegral to membrane Ref.1

Traceable author statement. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 241241Tetraspanin-1
PRO_0000219234

Regions

Topological domain1 – 1111Cytoplasmic Potential
Transmembrane12 – 3221 Potential
Topological domain33 – 5220Extracellular Potential
Transmembrane53 – 7321 Potential
Topological domain74 – 8815Cytoplasmic Potential
Transmembrane89 – 10921 Potential
Topological domain110 – 211102Extracellular Potential
Transmembrane212 – 23221 Potential
Topological domain233 – 2419Cytoplasmic Potential

Amino acid modifications

Glycosylation1411N-linked (GlcNAc...) Potential
Glycosylation1541N-linked (GlcNAc...) Potential
Glycosylation1781N-linked (GlcNAc...) Potential
Glycosylation1841N-linked (GlcNAc...) Potential

Natural variations

Natural variant871V → M: dbSNP rs2234268.
VAR_034573

Experimental info

Sequence conflict1891K → E in AAC69714. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O60635-1 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: AF938AD7147CB884

FASTA24126,301
        10         20         30         40         50         60 
MQCFSFIKTM MILFNLLIFL CGAALLAVGI WVSIDGASFL KIFGPLSSSA MQFVNVGYFL 

        70         80         90        100        110        120 
IAAGVVVFAL GFLGCYGAKT ESKCALVTFF FILLLIFIAE VAAAVVALVY TTMAEHFLTL 

       130        140        150        160        170        180 
LVVPAIKKDY GSQEDFTQVW NTTMKGLKCC GFTNYTDFED SPYFKENSAF PPFCCNDNVT 

       190        200        210        220        230        240 
NTANETCTKQ KAHDQKVEGC FNQLLYDIRT NAVTVGGVAA GIGGLELAAM IVSMYLYCNL 


Q 

« Hide

References

« Hide 'large scale' references
[1]"Sequences and expression of six new members of the tetraspanin/TM4SF family."
Todd S.C., Doctor V.S., Levy S.
Biochim. Biophys. Acta 1399:101-104(1998) [PubMed: 9714763] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"New tetraspans identified in the EST database."
Rubinstein E., Serru V., Boucheix C.
Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The molecular characterization of four tetraspanins."
Puls K.L., Ni J., Liu D., Morahan G., Wright M.D.
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
+Additional computationally mapped references.

Cross-references

Sequence databases

AF054838 mRNA. Translation: AAC69714.1.
AF065388 mRNA. Translation: AAC17119.1.
AF133425 mRNA. Translation: AAF08364.1.
BC007290 mRNA. Translation: AAH07290.1.
BC013404 mRNA. Translation: AAH13404.1.
PIRA59262.
RefSeqNP_005718.2.
UniGeneHs.38972

3D structure databases

ModBaseSearch...

Proteomic databases

PeptideAtlasO60635.

Genome annotation databases

EnsemblENSG00000117472. Homo sapiens. [Contig view]
GeneID10103.
KEGGhsa:10103.

Organism-specific databases

H-InvDBHIX0000543.
HGNCHGNC:20657. TSPAN1.
PharmGKBPA134938100.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMO60635.
HOVERGENO60635.

Gene expression databases

ArrayExpressO60635.
CleanExHS_TSPAN1.
GermOnlineENSG00000117472. Homo sapiens.

Family and domain databases

InterProIPR000301. Transmem_4.
[Graphical view]
PfamPF00335. Tetraspannin. 1 hit.
[Graphical view]
PRINTSPR00259. TMFOUR.
PROSITEPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio38217.

Entry information

Entry nameTSN1_HUMAN
AccessionPrimary (citable) accession number: O60635
Secondary accession number(s): O60745
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 4, 2008
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents