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Protein

15 kDa selenoprotein

Gene

SEP15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum (By similarity).By similarity

GO - Molecular functioni

  • selenium binding Source: UniProtKB

GO - Biological processi

  • 'de novo' posttranslational protein folding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
15 kDa selenoprotein
Gene namesi
Name:SEP15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum lumen Source: UniProtKB
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiSEPTIN15.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 16213415 kDa selenoproteinPRO_0000022307Add
BLAST

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

EPDiO60613.
MaxQBiO60613.
PaxDbiO60613.
PeptideAtlasiO60613.
PRIDEiO60613.

PTM databases

iPTMnetiO60613.
PhosphoSiteiO60613.
SwissPalmiO60613.

Expressioni

Tissue specificityi

Higher levels in prostate and thyroid gland.1 Publication

Gene expression databases

BgeeiENSG00000183291.

Interactioni

Subunit structurei

Forms a tight complex with UGGT1/UGCGL1.By similarity

Protein-protein interaction databases

BioGridi114800. 8 interactions.
IntActiO60613. 6 interactions.
STRINGi9606.ENSP00000328729.

Structurei

3D structure databases

ProteinModelPortaliO60613.
SMRiO60613. Positions 74-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the selenoprotein M/SEP15 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3384. Eukaryota.
ENOG4111MSS. LUCA.
HOGENOMiHOG000238561.
HOVERGENiHBG108472.
InParanoidiO60613.
PhylomeDBiO60613.

Family and domain databases

InterProiIPR014912. Sep15_SelM.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF08806. Sep15_SelM. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60613-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGPSGCLV PAFGLRLLLA TVLQAVSAFG AEFSSEACRE LGFSSNLLCS
60 70 80 90 100
SCDLLGQFNL LQLDPDCRGC CQEEAQFETK KLYAGAILEV CGUKLGRFPQ
110 120 130 140 150
VQAFVRSDKP KLFRGLQIKY VRGSDPVLKL LDDNGNIAEE LSILKWNTDS
160
VEEFLSEKLE RI
Length:162
Mass (Da):17,790
Last modified:February 26, 2008 - v3
Checksum:i55E382B423AA731E
GO
Isoform 2 (identifier: O60613-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-121: AFVRSDKPKLFRGLQIKYV → VCPWFRPCIKAFGRQWEHC
     122-162: Missing.

Note: No experimental confirmation available.
Show »
Length:121
Mass (Da):13,219
Checksum:iDA5C8905E60B24DC
GO

Sequence cautioni

The sequence AAH05294 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH16359 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH21697 differs from that shown. Reason: Erroneous initiation. Curated

Mass spectrometryi

Molecular mass is 14870 Da from positions 26 - 162. Determined by ESI. 1 Publication
Molecular mass is 14830 Da from positions 26 - 162. Determined by MALDI. 1 Publication

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei103 – 12119AFVRS…QIKYV → VCPWFRPCIKAFGRQWEHC in isoform 2. 1 PublicationVSP_014695Add
BLAST
Alternative sequencei122 – 16241Missing in isoform 2. 1 PublicationVSP_014696Add
BLAST

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei93 – 931Selenocysteine

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051894 mRNA. Translation: AAC15478.1.
AF288991 mRNA. Translation: AAG31556.1.
AF288992 Genomic DNA. Translation: AAG31557.1.
AF267982 Genomic DNA. Translation: AAF78966.1.
AL833575 mRNA. Translation: CAJ18323.1.
AL121989 Genomic DNA. Translation: CAC04186.1.
BC005294 mRNA. Translation: AAH05294.3. Different initiation.
BC016359 mRNA. Translation: AAH16359.3. Different initiation.
BC021697 mRNA. Translation: AAH21697.3. Different initiation.
RefSeqiNP_004252.2. NM_004261.3.
NP_976086.1. NM_203341.1.
UniGeneiHs.362728.

Genome annotation databases

GeneIDi9403.
KEGGihsa:9403.

Keywords - Coding sequence diversityi

Alternative splicing, Selenocysteine

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051894 mRNA. Translation: AAC15478.1.
AF288991 mRNA. Translation: AAG31556.1.
AF288992 Genomic DNA. Translation: AAG31557.1.
AF267982 Genomic DNA. Translation: AAF78966.1.
AL833575 mRNA. Translation: CAJ18323.1.
AL121989 Genomic DNA. Translation: CAC04186.1.
BC005294 mRNA. Translation: AAH05294.3. Different initiation.
BC016359 mRNA. Translation: AAH16359.3. Different initiation.
BC021697 mRNA. Translation: AAH21697.3. Different initiation.
RefSeqiNP_004252.2. NM_004261.3.
NP_976086.1. NM_203341.1.
UniGeneiHs.362728.

3D structure databases

ProteinModelPortaliO60613.
SMRiO60613. Positions 74-161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114800. 8 interactions.
IntActiO60613. 6 interactions.
STRINGi9606.ENSP00000328729.

PTM databases

iPTMnetiO60613.
PhosphoSiteiO60613.
SwissPalmiO60613.

Polymorphism and mutation databases

BioMutaiSEPTIN15.

Proteomic databases

EPDiO60613.
MaxQBiO60613.
PaxDbiO60613.
PeptideAtlasiO60613.
PRIDEiO60613.

Protocols and materials databases

DNASUi9403.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9403.
KEGGihsa:9403.

Organism-specific databases

CTDi9403.
GeneCardsiSEP15.
MIMi606254. gene.
neXtProtiNX_O60613.

Phylogenomic databases

eggNOGiKOG3384. Eukaryota.
ENOG4111MSS. LUCA.
HOGENOMiHOG000238561.
HOVERGENiHBG108472.
InParanoidiO60613.
PhylomeDBiO60613.

Miscellaneous databases

GeneWikiiSEP15.
GenomeRNAii9403.
PROiO60613.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183291.

Family and domain databases

InterProiIPR014912. Sep15_SelM.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF08806. Sep15_SelM. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSEP15_HUMAN
AccessioniPrimary (citable) accession number: O60613
Secondary accession number(s): Q4GZG7
, Q8WU00, Q9BS64, Q9GZW0, Q9NR01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 26, 2008
Last modified: September 7, 2016
This is version 144 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.