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Protein

Selenoprotein F

Gene

SELENOF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum (By similarity).By similarity

GO - Biological processi

  • 'de novo' posttranslational protein folding Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Selenoprotein F1 Publication
Alternative name(s):
15 kDa selenoprotein1 Publication
Gene namesi
Name:SELENOF1 PublicationImported
Synonyms:SEP151 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:17705. SELENOF.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi9403.

Polymorphism and mutation databases

BioMutaiSEPTIN15.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000002230729 – 162Selenoprotein FAdd BLAST134

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

EPDiO60613.
MaxQBiO60613.
PaxDbiO60613.
PeptideAtlasiO60613.
PRIDEiO60613.

PTM databases

iPTMnetiO60613.
PhosphoSitePlusiO60613.
SwissPalmiO60613.

Expressioni

Tissue specificityi

Higher levels in prostate and thyroid gland.1 Publication

Organism-specific databases

HPAiHPA054937.

Interactioni

Subunit structurei

Forms a tight complex with UGGT1/UGCGL1.By similarity

Protein-protein interaction databases

BioGridi114800. 25 interactors.
IntActiO60613. 7 interactors.
STRINGi9606.ENSP00000328729.

Structurei

3D structure databases

ProteinModelPortaliO60613.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the selenoprotein M/F family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3384. Eukaryota.
ENOG4111MSS. LUCA.
HOGENOMiHOG000238561.
HOVERGENiHBG108472.
InParanoidiO60613.
PhylomeDBiO60613.

Family and domain databases

InterProiView protein in InterPro
IPR014912. Sep15_SelM.
IPR036249. Thioredoxin-like_sf.
PfamiView protein in Pfam
PF08806. Sep15_SelM. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60613-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGPSGCLV PAFGLRLLLA TVLQAVSAFG AEFSSEACRE LGFSSNLLCS
60 70 80 90 100
SCDLLGQFNL LQLDPDCRGC CQEEAQFETK KLYAGAILEV CGUKLGRFPQ
110 120 130 140 150
VQAFVRSDKP KLFRGLQIKY VRGSDPVLKL LDDNGNIAEE LSILKWNTDS
160
VEEFLSEKLE RI
Length:162
Mass (Da):17,790
Last modified:February 26, 2008 - v3
Checksum:i55E382B423AA731E
GO
Isoform 2 (identifier: O60613-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-121: AFVRSDKPKLFRGLQIKYV → VCPWFRPCIKAFGRQWEHC
     122-162: Missing.

Note: No experimental confirmation available.
Show »
Length:121
Mass (Da):13,219
Checksum:iDA5C8905E60B24DC
GO

Sequence cautioni

O60613: The sequence AAH05294 differs from that shown. Reason: Erroneous initiation.Curated
O60613: The sequence AAH16359 differs from that shown. Reason: Erroneous initiation.Curated
O60613: The sequence AAH21697 differs from that shown. Reason: Erroneous initiation.Curated

Mass spectrometryi

O60613: Molecular mass is 14870 Da from positions 26 - 162. Determined by ESI. 1 Publication
O60613: Molecular mass is 14830 Da from positions 26 - 162. Determined by MALDI. 1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014695103 – 121AFVRS…QIKYV → VCPWFRPCIKAFGRQWEHC in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_014696122 – 162Missing in isoform 2. 1 PublicationAdd BLAST41

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei93Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051894 mRNA. Translation: AAC15478.1.
AF288991 mRNA. Translation: AAG31556.1.
AF288992 Genomic DNA. Translation: AAG31557.1.
AF267982 Genomic DNA. Translation: AAF78966.1.
AL833575 mRNA. Translation: CAJ18323.1.
AL121989 Genomic DNA. Translation: CAC04186.1.
BC005294 mRNA. Translation: AAH05294.3. Different initiation.
BC016359 mRNA. Translation: AAH16359.3. Different initiation.
BC021697 mRNA. Translation: AAH21697.3. Different initiation.
RefSeqiNP_004252.2. NM_004261.4.
NP_976086.1. NM_203341.2.
UniGeneiHs.362728.

Genome annotation databases

GeneIDi9403.
KEGGihsa:9403.

Keywords - Coding sequence diversityi

Alternative splicing, Selenocysteine

Similar proteinsi

Entry informationi

Entry nameiSEP15_HUMAN
AccessioniPrimary (citable) accession number: O60613
Secondary accession number(s): Q4GZG7
, Q8WU00, Q9BS64, Q9GZW0, Q9NR01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 26, 2008
Last modified: October 25, 2017
This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families