##gff-version 3 O60610 UniProtKB Chain 1 1272 . . . ID=PRO_0000194893;Note=Protein diaphanous homolog 1 O60610 UniProtKB Domain 84 449 . . . Note=GBD/FH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00579 O60610 UniProtKB Domain 583 764 . . . Note=FH1 O60610 UniProtKB Domain 769 1171 . . . Note=FH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00774 O60610 UniProtKB Domain 1194 1222 . . . Note=DAD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00577 O60610 UniProtKB Region 1 84 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60610 UniProtKB Region 573 755 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60610 UniProtKB Coiled coil 468 572 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 O60610 UniProtKB Coiled coil 1039 1196 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 O60610 UniProtKB Compositional bias 36 67 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60610 UniProtKB Compositional bias 68 84 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60610 UniProtKB Compositional bias 576 627 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60610 UniProtKB Compositional bias 635 663 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60610 UniProtKB Compositional bias 670 755 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60610 UniProtKB Modified residue 1 1 . . . Note=N-acetylmethionine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:22223895,ECO:0007744|PubMed:22814378;Dbxref=PMID:22223895,PMID:22814378 O60610 UniProtKB Modified residue 7 7 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 O60610 UniProtKB Modified residue 22 22 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163 O60610 UniProtKB Modified residue 36 36 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 O60610 UniProtKB Modified residue 768 768 . . . Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23325789;Dbxref=PMID:23325789 O60610 UniProtKB Modified residue 1057 1057 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 O60610 UniProtKB Modified residue 1103 1103 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 O60610 UniProtKB Modified residue 1121 1121 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08808 O60610 UniProtKB Modified residue 1251 1251 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 O60610 UniProtKB Modified residue 1254 1254 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 O60610 UniProtKB Alternative sequence 40 48 . . . ID=VSP_035870;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9360932,ECO:0000303|Ref.2;Dbxref=PMID:14702039,PMID:15489334,PMID:9360932 O60610 UniProtKB Alternative sequence 621 632 . . . ID=VSP_035871;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:9360932,ECO:0000303|Ref.2;Dbxref=PMID:14702039,PMID:9360932 O60610 UniProtKB Alternative sequence 826 828 . . . ID=VSP_035872;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:9360932,ECO:0000303|Ref.2;Dbxref=PMID:14702039,PMID:9360932 O60610 UniProtKB Natural variant 678 678 . . . ID=VAR_079874;Note=In DFNA1. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22938506;Dbxref=dbSNP:rs186370335,PMID:22938506 O60610 UniProtKB Natural variant 1213 1272 . . . ID=VAR_078862;Note=In DFNA1%3B with thrombocytopenia%3B affects function in regulation of cytoskeleton organization. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:26912466,ECO:0000269|PubMed:27808407;Dbxref=PMID:26912466,PMID:27808407 O60610 UniProtKB Mutagenesis 154 154 . . . Note=Partial decrease of phosphorylation. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23325789;Dbxref=PMID:23325789 O60610 UniProtKB Mutagenesis 768 768 . . . Note=Substantial loss of phosphorylation%2C no increase of phosphorylation in response to cAMP%2C increased stability%2C reduced interaction with OSBPL2 and OSBPL10 and reduced mitochondrial movement. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23325789;Dbxref=PMID:23325789 O60610 UniProtKB Mutagenesis 1091 1091 . . . Note=Substantial loss of phosphorylation. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23325789;Dbxref=PMID:23325789 O60610 UniProtKB Mutagenesis 1238 1238 . . . Note=Substantial loss of phosphorylation. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23325789;Dbxref=PMID:23325789 O60610 UniProtKB Sequence conflict 13 13 . . . Note=G->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 O60610 UniProtKB Sequence conflict 609 609 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 O60610 UniProtKB Sequence conflict 1156 1156 . . . Note=R->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 O60610 UniProtKB Sequence conflict 1157 1157 . . . Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305