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O60609

- GFRA3_HUMAN

UniProt

O60609 - GFRA3_HUMAN

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Protein
GDNF family receptor alpha-3
Gene
GFRA3, UNQ339/PRO538/PRO3664
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.1 Publication

GO - Molecular functioni

  1. axon guidance receptor activity Source: Ensembl
  2. receptor binding Source: ProtInc

GO - Biological processi

  1. nervous system development Source: ProtInc
  2. neuron migration Source: Ensembl
  3. peripheral nervous system development Source: ProtInc
  4. signal transduction Source: ProtInc
  5. sympathetic nervous system development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
GDNF family receptor alpha-3
Short name:
GDNF receptor alpha-3
Short name:
GDNFR-alpha-3
Short name:
GFR-alpha-3
Gene namesi
Name:GFRA3
ORF Names:UNQ339/PRO538/PRO3664
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:4245. GFRA3.

Subcellular locationi

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. cytoplasm Source: HPA
  3. external side of plasma membrane Source: Ensembl
  4. extrinsic component of membrane Source: ProtInc
  5. intracellular membrane-bounded organelle Source: HPA
  6. plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28655.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 31311 Publication
Add
BLAST
Chaini32 – 374343GDNF family receptor alpha-3
PRO_0000010789Add
BLAST
Propeptidei375 – 40026Removed in mature form Reviewed prediction
PRO_0000010790Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi95 – 951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi148 – 1481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi309 – 3091N-linked (GlcNAc...)1 Publication
Lipidationi374 – 3741GPI-anchor amidated asparagine Reviewed prediction

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO60609.
PRIDEiO60609.

PTM databases

PhosphoSiteiO60609.

Expressioni

Tissue specificityi

Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system.1 Publication

Gene expression databases

ArrayExpressiO60609.
BgeeiO60609.
CleanExiHS_GFRA3.
GenevestigatoriO60609.

Organism-specific databases

HPAiHPA020731.

Interactioni

Protein-protein interaction databases

BioGridi108944. 1 interaction.
DIPiDIP-29114N.
STRINGi9606.ENSP00000274721.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi161 – 17010
Helixi173 – 18513
Turni188 – 1903
Helixi193 – 20614
Helixi209 – 2168
Helixi225 – 2339
Helixi237 – 2404
Helixi248 – 2569
Helixi259 – 27113
Beta strandi274 – 2763
Beta strandi281 – 2833
Helixi285 – 2939
Turni294 – 2974
Beta strandi302 – 3043
Beta strandi307 – 3093
Beta strandi312 – 3154
Helixi322 – 3243
Helixi325 – 33612
Helixi339 – 35517

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GH0X-ray1.92A/B151-363[»]
ProteinModelPortaliO60609.
SMRiO60609. Positions 158-357.

Miscellaneous databases

EvolutionaryTraceiO60609.

Family & Domainsi

Sequence similaritiesi

Belongs to the GDNFR family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG83952.
HOGENOMiHOG000059598.
HOVERGENiHBG051726.
InParanoidiO60609.
OMAiQLFSQDW.
OrthoDBiEOG7FBRJ3.
PhylomeDBiO60609.
TreeFamiTF331647.

Family and domain databases

InterProiIPR016017. GDNF/GAS1.
IPR003438. GDNF_rcpt.
IPR003505. GDNF_rcpt_A3.
[Graphical view]
PfamiPF02351. GDNF. 3 hits.
[Graphical view]
PRINTSiPR01319. GDNFRALPHA3.
PR01316. GDNFRECEPTOR.
SMARTiSM00907. GDNF. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O60609-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVRPLNPRPL PPVVLMLLLL LPPSPLPLAA GDPLPTESRL MNSCLQARRK    50
CQADPTCSAA YHHLDSCTSS ISTPLPSEEP SVPADCLEAA QQLRNSSLIG 100
CMCHRRMKNQ VACLDIYWTV HRARSLGNYE LDVSPYEDTV TSKPWKMNLS 150
KLNMLKPDSD LCLKFAMLCT LNDKCDRLRK AYGEACSGPH CQRHVCLRQL 200
LTFFEKAAEP HAQGLLLCPC APNDRGCGER RRNTIAPNCA LPPVAPNCLE 250
LRRLCFSDPL CRSRLVDFQT HCHPMDILGT CATEQSRCLR AYLGLIGTAM 300
TPNFVSNVNT SVALSCTCRG SGNLQEECEM LEGFFSHNPC LTEAIAAKMR 350
FHSQLFSQDW PHPTFAVMAH QNENPAVRPQ PWVPSLFSCT LPLILLLSLW 400
Length:400
Mass (Da):44,511
Last modified:July 19, 2004 - v2
Checksum:iB0BC252FE1F072C7
GO
Isoform 2 (identifier: O60609-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     127-157: Missing.

Show »
Length:369
Mass (Da):40,930
Checksum:i43DEAB2E6B900CE3
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei127 – 15731Missing in isoform 2.
VSP_010942Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti108 – 1081K → R in AAC24355. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF051767 mRNA. Translation: AAC24355.1.
AY358997 mRNA. Translation: AAQ89356.1.
AY359037 mRNA. Translation: AAQ89396.1.
AK297693 mRNA. Translation: BAG60051.1.
AK314022 mRNA. Translation: BAG36733.1.
CH471062 Genomic DNA. Translation: EAW62152.1.
CH471062 Genomic DNA. Translation: EAW62153.1.
BC037951 mRNA. Translation: AAH37951.1.
CCDSiCCDS4201.1. [O60609-1]
RefSeqiNP_001487.2. NM_001496.3. [O60609-1]
UniGeneiHs.58042.

Genome annotation databases

EnsembliENST00000274721; ENSP00000274721; ENSG00000146013. [O60609-1]
ENST00000378362; ENSP00000367613; ENSG00000146013. [O60609-2]
GeneIDi2676.
KEGGihsa:2676.
UCSCiuc003lcn.3. human. [O60609-1]
uc003lco.3. human. [O60609-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF051767 mRNA. Translation: AAC24355.1 .
AY358997 mRNA. Translation: AAQ89356.1 .
AY359037 mRNA. Translation: AAQ89396.1 .
AK297693 mRNA. Translation: BAG60051.1 .
AK314022 mRNA. Translation: BAG36733.1 .
CH471062 Genomic DNA. Translation: EAW62152.1 .
CH471062 Genomic DNA. Translation: EAW62153.1 .
BC037951 mRNA. Translation: AAH37951.1 .
CCDSi CCDS4201.1. [O60609-1 ]
RefSeqi NP_001487.2. NM_001496.3. [O60609-1 ]
UniGenei Hs.58042.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2GH0 X-ray 1.92 A/B 151-363 [» ]
ProteinModelPortali O60609.
SMRi O60609. Positions 158-357.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108944. 1 interaction.
DIPi DIP-29114N.
STRINGi 9606.ENSP00000274721.

PTM databases

PhosphoSitei O60609.

Proteomic databases

PaxDbi O60609.
PRIDEi O60609.

Protocols and materials databases

DNASUi 2676.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000274721 ; ENSP00000274721 ; ENSG00000146013 . [O60609-1 ]
ENST00000378362 ; ENSP00000367613 ; ENSG00000146013 . [O60609-2 ]
GeneIDi 2676.
KEGGi hsa:2676.
UCSCi uc003lcn.3. human. [O60609-1 ]
uc003lco.3. human. [O60609-2 ]

Organism-specific databases

CTDi 2676.
GeneCardsi GC05M137588.
HGNCi HGNC:4245. GFRA3.
HPAi HPA020731.
MIMi 605710. gene.
neXtProti NX_O60609.
PharmGKBi PA28655.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG83952.
HOGENOMi HOG000059598.
HOVERGENi HBG051726.
InParanoidi O60609.
OMAi QLFSQDW.
OrthoDBi EOG7FBRJ3.
PhylomeDBi O60609.
TreeFami TF331647.

Miscellaneous databases

EvolutionaryTracei O60609.
GeneWikii GFRA3.
GenomeRNAii 2676.
NextBioi 10566.
PROi O60609.
SOURCEi Search...

Gene expression databases

ArrayExpressi O60609.
Bgeei O60609.
CleanExi HS_GFRA3.
Genevestigatori O60609.

Family and domain databases

InterProi IPR016017. GDNF/GAS1.
IPR003438. GDNF_rcpt.
IPR003505. GDNF_rcpt_A3.
[Graphical view ]
Pfami PF02351. GDNF. 3 hits.
[Graphical view ]
PRINTSi PR01319. GDNFRALPHA3.
PR01316. GDNFRECEPTOR.
SMARTi SM00907. GDNF. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Lung and Substantia nigra.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pancreas.
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 32-46.
  7. "Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex."
    Baloh R.H., Tansey M.G., Lampe P.A., Fahrner T.J., Enomoto H., Simburger K.S., Leitner M.L., Araki T., Johnson E.M. Jr., Milbrandt J.
    Neuron 21:1291-1302(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors."
    Wang X., Baloh R.H., Milbrandt J., Garcia K.C.
    Structure 14:1083-1092(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.92 ANGSTROMS) OF 151-363 IN COMPLEX WITH ARTN, GLYCOSYLATION AT ASN-309.

Entry informationi

Entry nameiGFRA3_HUMAN
AccessioniPrimary (citable) accession number: O60609
Secondary accession number(s): B2RA36
, B4DMY9, Q6UW20, Q8IUZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 19, 2004
Last modified: July 9, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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