Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Iduronate 2-sulfatase

Gene

IDS

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Iduronate 2-sulfataseImported
Submitted name:
Iduronate-2-sulfataseImported
Gene namesi
Name:IDSImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:5389. IDS.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000010404.

Protein family/group databases

Allergomei9623. Hom s Idursulfase.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_500769698426 – 179Sequence analysisAdd BLAST154

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei843-oxoalanine (Cys)UniRule annotation1

Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.UniRule annotation

Proteomic databases

MaxQBiO60597.
PeptideAtlasiO60597.
PRIDEiO60597.

Expressioni

Gene expression databases

BgeeiENSG00000010404.
ExpressionAtlasiO60597. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliO60597.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 153SulfataseInterPro annotationAdd BLAST116

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00730000110906.
HOGENOMiHOG000207088.
HOVERGENiHBG053054.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR024607. Sulfatase_CS.
IPR000917. Sulfatase_N.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60597-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPPRTGRGL LWLGLVLSSV CVALGSETQA NSTTDALNVL LIIVDDLRPS
60 70 80 90 100
LGCYGDKLVR SPNIDQLASH SLLFQNAFAQ QAVCAPSRVS FLTGRRPDTT
110 120 130 140 150
RLYDFNSYWR VHAGNFSTIP QYFKENGYVT MSVGKVFHPG TAPCPESGFS
160 170
WFVVSESSIP ILGMGLSLQS PLLAGRVPR
Length:179
Mass (Da):19,460
Last modified:August 1, 1998 - v1
Checksum:iD2CCD03D39182598
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC233288 Genomic DNA. No translation available.
AC244197 Genomic DNA. No translation available.
AF050145 mRNA. Translation: AAC05984.1.
UniGeneiHs.460960.
Hs.6795.

Genome annotation databases

EnsembliENST00000428056; ENSP00000390241; ENSG00000010404.
UCSCiuc011mxj.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC233288 Genomic DNA. No translation available.
AC244197 Genomic DNA. No translation available.
AF050145 mRNA. Translation: AAC05984.1.
UniGeneiHs.460960.
Hs.6795.

3D structure databases

ProteinModelPortaliO60597.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei9623. Hom s Idursulfase.

Proteomic databases

MaxQBiO60597.
PeptideAtlasiO60597.
PRIDEiO60597.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000428056; ENSP00000390241; ENSG00000010404.
UCSCiuc011mxj.3. human.

Organism-specific databases

HGNCiHGNC:5389. IDS.
OpenTargetsiENSG00000010404.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00730000110906.
HOGENOMiHOG000207088.
HOVERGENiHBG053054.

Miscellaneous databases

ChiTaRSiIDS. human.

Gene expression databases

BgeeiENSG00000010404.
ExpressionAtlasiO60597. baseline and differential.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR024607. Sulfatase_CS.
IPR000917. Sulfatase_N.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO60597_HUMAN
AccessioniPrimary (citable) accession number: O60597
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.