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Protein

Interleukin-12 subunit alpha

Gene

IL12A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.UniRule annotation

GO - Molecular functioni

  • interleukin-12 beta subunit binding Source: AgBase
  • protein heterodimerization activity Source: AgBase

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotation, Growth factorUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-12 subunit alphaUniRule annotation
Short name:
IL-12AUniRule annotation
Gene namesi
Name:IL12AUniRule annotationImported
ORF Names:hCG_1685939Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Secreted UniRule annotation

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • interleukin-12 complex Source: AgBase

Keywords - Cellular componenti

SecretedUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29784.

PTM / Processingi

Keywords - PTMi

Disulfide bondUniRule annotation

Expressioni

Gene expression databases

BgeeiENSG00000168811.
ExpressionAtlasiO60595. baseline and differential.

Interactioni

Subunit structurei

Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.UniRule annotation

GO - Molecular functioni

  • interleukin-12 beta subunit binding Source: AgBase
  • protein heterodimerization activity Source: AgBase

Protein-protein interaction databases

STRINGi9606.ENSP00000303231.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IVIR. Eukaryota.
ENOG410ZGHJ. LUCA.
HOGENOMiHOG000113026.
HOVERGENiHBG063691.
KOiK05406.
OMAiNFNSETV.
OrthoDBiEOG091G13SK.
PhylomeDBiO60595.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR004281. IL-12_alpha.
PfamiView protein in Pfam
PF03039. IL12. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

O60595-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWPPGSASQP PPSPAAATGL HPAARPVSLQ CRLSMCPARS LLLVATLVLL
60 70 80 90 100
DHLSLARNLP VATPDPGMFP CLHHSQNLLR AVSNMLQKAR QTLEFYPCTS
110 120 130 140 150
EEIDHEDITK DKTSTVEACL PLELTKNESC LNSRETSFIT NGSCLASRKT
160 170 180 190 200
SFMMALCLSS IYEDLKMYQV EFKTMNAKLL MDPKRQIFLD QNMLAVIDEL
210 220 230 240 250
MQALNFNSET VPQKSSLEEP DFYKTKIKLC ILLHAFRIRA VTIDRVMSYL

NAS
Length:253
Mass (Da):28,293
Last modified:August 1, 1999 - v2
Checksum:iFAC56ACD2A620BD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF101062 mRNA. Translation: AAD16432.1.
AF180562 mRNA. Translation: AAD56385.1.
BC104982 mRNA. Translation: AAI04983.1.
BC104984 mRNA. Translation: AAI04985.1.
CH471052 Genomic DNA. Translation: EAW78656.1.
PIRiB38957.
RefSeqiNP_000873.2. NM_000882.3.
UniGeneiHs.673.

Genome annotation databases

GeneIDi3592.
KEGGihsa:3592.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF101062 mRNA. Translation: AAD16432.1.
AF180562 mRNA. Translation: AAD56385.1.
BC104982 mRNA. Translation: AAI04983.1.
BC104984 mRNA. Translation: AAI04985.1.
CH471052 Genomic DNA. Translation: EAW78656.1.
PIRiB38957.
RefSeqiNP_000873.2. NM_000882.3.
UniGeneiHs.673.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000303231.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3592.
KEGGihsa:3592.

Organism-specific databases

CTDi3592.
PharmGKBiPA29784.

Phylogenomic databases

eggNOGiENOG410IVIR. Eukaryota.
ENOG410ZGHJ. LUCA.
HOGENOMiHOG000113026.
HOVERGENiHBG063691.
KOiK05406.
OMAiNFNSETV.
OrthoDBiEOG091G13SK.
PhylomeDBiO60595.

Miscellaneous databases

GenomeRNAii3592.

Gene expression databases

BgeeiENSG00000168811.
ExpressionAtlasiO60595. baseline and differential.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR004281. IL-12_alpha.
PfamiView protein in Pfam
PF03039. IL12. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO60595_HUMAN
AccessioniPrimary (citable) accession number: O60595
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1999
Last modified: February 15, 2017
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.