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Protein

Serine protease inhibitor Kazal-type 4

Gene

SPINK4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei48 – 492Reactive bondPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI01.970.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease inhibitor Kazal-type 4
Alternative name(s):
Peptide PEC-60 homolog
Gene namesi
Name:SPINK4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:16646. SPINK4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38180.

Polymorphism and mutation databases

BioMutaiSPINK4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626By similarityAdd
BLAST
Chaini27 – 8660Serine protease inhibitor Kazal-type 4PRO_0000016569Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 68PROSITE-ProRule annotation
Disulfide bondi46 ↔ 65PROSITE-ProRule annotation
Disulfide bondi54 ↔ 86PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO60575.
PeptideAtlasiO60575.
PRIDEiO60575.

Expressioni

Gene expression databases

BgeeiO60575.
CleanExiHS_SPINK4.
ExpressionAtlasiO60575. baseline and differential.
GenevisibleiO60575. HS.

Organism-specific databases

HPAiHPA007286.

Interactioni

Protein-protein interaction databases

BioGridi118114. 8 interactions.
STRINGi9606.ENSP00000369045.

Structurei

3D structure databases

ProteinModelPortaliO60575.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 8656Kazal-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3649. Eukaryota.
ENOG410YC3T. LUCA.
HOGENOMiHOG000090244.
HOVERGENiHBG006182.
InParanoidiO60575.
OMAiTCSQTSN.
OrthoDBiEOG7BW0M2.
PhylomeDBiO60575.

Family and domain databases

InterProiIPR002350. Kazal_dom.
[Graphical view]
PfamiPF00050. Kazal_1. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
[Graphical view]
PROSITEiPS00282. KAZAL_1. 1 hit.
PS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60575-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVRQWVIAL ALAALLVVDR EVPVAAGKLP FSRMPICEHM VESPTCSQMS
60 70 80
NLVCGTDGLT YTNECQLCLA RIKTKQDIQI MKDGKC
Length:86
Mass (Da):9,454
Last modified:August 1, 1998 - v1
Checksum:i374CD4B3CAC9AF52
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71V → I.
Corresponds to variant rs706107 [ dbSNP | Ensembl ].
VAR_011898

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF048700 mRNA. Translation: AAC05124.1.
AL161445 Genomic DNA. Translation: CAD13307.1.
BC110068 mRNA. Translation: AAI10069.1.
CCDSiCCDS6536.1.
RefSeqiNP_055286.1. NM_014471.1.
UniGeneiHs.555934.

Genome annotation databases

EnsembliENST00000379721; ENSP00000369045; ENSG00000122711.
GeneIDi27290.
KEGGihsa:27290.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF048700 mRNA. Translation: AAC05124.1.
AL161445 Genomic DNA. Translation: CAD13307.1.
BC110068 mRNA. Translation: AAI10069.1.
CCDSiCCDS6536.1.
RefSeqiNP_055286.1. NM_014471.1.
UniGeneiHs.555934.

3D structure databases

ProteinModelPortaliO60575.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118114. 8 interactions.
STRINGi9606.ENSP00000369045.

Protein family/group databases

MEROPSiI01.970.

Polymorphism and mutation databases

BioMutaiSPINK4.

Proteomic databases

PaxDbiO60575.
PeptideAtlasiO60575.
PRIDEiO60575.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379721; ENSP00000369045; ENSG00000122711.
GeneIDi27290.
KEGGihsa:27290.

Organism-specific databases

CTDi27290.
GeneCardsiSPINK4.
HGNCiHGNC:16646. SPINK4.
HPAiHPA007286.
MIMi613929. gene.
neXtProtiNX_O60575.
PharmGKBiPA38180.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3649. Eukaryota.
ENOG410YC3T. LUCA.
HOGENOMiHOG000090244.
HOVERGENiHBG006182.
InParanoidiO60575.
OMAiTCSQTSN.
OrthoDBiEOG7BW0M2.
PhylomeDBiO60575.

Miscellaneous databases

GenomeRNAii27290.
PROiO60575.
SOURCEiSearch...

Gene expression databases

BgeeiO60575.
CleanExiHS_SPINK4.
ExpressionAtlasiO60575. baseline and differential.
GenevisibleiO60575. HS.

Family and domain databases

InterProiIPR002350. Kazal_dom.
[Graphical view]
PfamiPF00050. Kazal_1. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
[Graphical view]
PROSITEiPS00282. KAZAL_1. 1 hit.
PS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human gastrointestinal peptide mRNA, homolog of swine PEC-60."
    Hu G.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiISK4_HUMAN
AccessioniPrimary (citable) accession number: O60575
Secondary accession number(s): Q2YDT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: July 6, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.