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O60566

- BUB1B_HUMAN

UniProt

O60566 - BUB1B_HUMAN

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Protein

Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Gene

BUB1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.6 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Kinase activity stimulated by CENPE.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei579 – 5802Cleavage; by caspase-3
Sitei610 – 6112Cleavage; by caspase-3
Binding sitei795 – 7951ATPBy similarity
Active sitei882 – 8821Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi772 – 7809ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein kinase activity Source: UniProtKB
  3. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Source: Reactome
  2. apoptotic process Source: UniProtKB-KW
  3. cell proliferation Source: ProtInc
  4. metaphase/anaphase transition of mitotic cell cycle Source: Ensembl
  5. mitotic cell cycle Source: Reactome
  6. mitotic cell cycle checkpoint Source: ProtInc
  7. mitotic nuclear division Source: UniProtKB
  8. mitotic spindle assembly checkpoint Source: Reactome
  9. negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
  10. protein localization to chromosome, centromeric region Source: Ensembl
  11. protein localization to kinetochore Source: UniProtKB
  12. regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Apoptosis, Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 2681.
ReactomeiREACT_1072. Inactivation of APC/C via direct inhibition of the APC/C complex.
REACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_6781. APC/C:Cdc20 mediated degradation of mitotic proteins.
REACT_682. Mitotic Prometaphase.
SignaLinkiO60566.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC:2.7.11.1)
Alternative name(s):
MAD3/BUB1-related protein kinase
Short name:
hBUBR1
Mitotic checkpoint kinase MAD3L
Protein SSK1
Gene namesi
Name:BUB1B
Synonyms:BUBR1, MAD3L, SSK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:1149. BUB1B.

Subcellular locationi

Cytoplasm. Nucleus. Chromosomecentromerekinetochore. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome
Note: Cytoplasmic in interphase cells. Associates with the kinetochores in early prophase. Kinetochore localization requires BUB1, PLK1 and CASC5.

GO - Cellular componenti

  1. anaphase-promoting complex Source: ProtInc
  2. condensed chromosome kinetochore Source: UniProtKB
  3. condensed chromosome outer kinetochore Source: UniProtKB
  4. condensed nuclear chromosome kinetochore Source: Ensembl
  5. cytoplasm Source: LIFEdb
  6. cytosol Source: Reactome
  7. kinetochore Source: UniProtKB
  8. perinuclear region of cytoplasm Source: BHF-UCL
  9. spindle midzone Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in BUB1B are associated with tumor formation.
Premature chromatid separation trait (PCS) [MIM:176430]: Consists of separate and splayed chromatids with discernible centromeres and involves all or most chromosomes of a metaphase. It is found in up to 2% of metaphases in cultured lymphocytes from approximately 40% of normal individuals. When PCS is present in 5% or more of cells, it is known as the heterozygous PCS trait and has no obvious phenotypic effect, although some have reported decreased fertility. Inheritance is autosomal dominant.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti36 – 361R → Q in PCS. 1 Publication
VAR_028921
Mosaic variegated aneuploidy syndrome 1 (MVA1) [MIM:257300]: A severe developmental disorder characterized by mosaic aneuploidies, predominantly trisomies and monosomies, involving multiple different chromosomes and tissues. Affected individuals typically present with severe intrauterine growth retardation and microcephaly. Eye anomalies, mild dysmorphism, variable developmental delay, and a broad spectrum of additional congenital abnormalities and medical conditions may also occur. The risk of malignancy is high, with rhabdomyosarcoma, Wilms tumor and leukemia reported in several cases.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry. MVA1 is caused by biallelic mutations in the BUB1B gene.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti550 – 5501R → Q in MVA1; heterozygous compound with nonsense mutation. 1 Publication
Corresponds to variant rs28989187 [ dbSNP | Ensembl ].
VAR_028923
Natural varianti814 – 8141R → H in MVA1; heterozygous compound with nonsense mutation. 1 Publication
Corresponds to variant rs28989182 [ dbSNP | Ensembl ].
VAR_028924
Natural varianti844 – 8441L → F in MVA1; associated with H-921; heterozygous compound with nonsense mutation. 1 Publication
Corresponds to variant rs28989181 [ dbSNP | Ensembl ].
VAR_028925
Natural varianti909 – 9091I → T in MVA1; heterozygous compound with nonsense mutation. 1 Publication
Corresponds to variant rs28989184 [ dbSNP | Ensembl ].
VAR_028926
Natural varianti921 – 9211Q → H in MVA1; associated with F-844; heterozygous compound with nonsense mutation. 1 Publication
Corresponds to variant rs28989183 [ dbSNP | Ensembl ].
VAR_028927
Natural varianti1012 – 10121L → P in MVA1; heterozygous compound with nonsense mutation. 1 Publication
Corresponds to variant rs28989185 [ dbSNP | Ensembl ].
VAR_028928

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi159 – 1591A → W: Loss of interaction with CASC5. 1 Publication
Mutagenesisi175 – 1751F → A: Loss of interaction with CASC5. 1 Publication
Mutagenesisi579 – 5791D → E: Abolishes the cleavage by caspase-3. 1 Publication
Mutagenesisi610 – 6101D → E: Abolishes the cleavage by caspase-3. 1 Publication
Mutagenesisi620 – 6201T → A: Induces chromosome congression defects and mitotic delay. 1 Publication
Mutagenesisi795 – 7951K → A: Does not abolish the capacity to inhibit APC/CDC20. 2 Publications
Mutagenesisi795 – 7951K → R: Inhibits kinase activity. 2 Publications

Keywords - Diseasei

Disease mutation, Tumor suppressor

Organism-specific databases

MIMi176430. phenotype.
257300. phenotype.
Orphaneti1052. Mosaic variegated aneuploidy syndrome.
PharmGKBiPA82.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10501050Mitotic checkpoint serine/threonine-protein kinase BUB1 betaPRO_0000085673Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei250 – 2501N6-acetyllysine; by PCAF1 Publication
Modified residuei435 – 4351Phosphoserine1 Publication
Modified residuei543 – 5431Phosphoserine2 Publications
Modified residuei670 – 6701Phosphoserine4 Publications
Modified residuei676 – 6761Phosphoserine; by PLK11 Publication
Modified residuei792 – 7921Phosphothreonine; by PLK11 Publication
Modified residuei1008 – 10081Phosphothreonine; by PLK11 Publication
Modified residuei1042 – 10421Phosphothreonine1 Publication
Modified residuei1043 – 10431Phosphoserine1 Publication

Post-translational modificationi

Proteolytically cleaved by caspase-3 in a cell cycle specific manner. The cleavage might be involved in the durability of the cell cycle delay. Caspase-3 cleavage is associated with abrogation of the mitotic checkpoint. The major site of cleavage is at Asp-610.
Acetylation at Lys-250 regulates its degradation and timing in anaphase entry.1 Publication
Ubiquitinated. Degraded by the proteasome.1 Publication
Sumoylated with SUMO2 and SUMO3. The sumoylation mediates the association with CENPE at the kinetochore.1 Publication
Autophosphorylated in vitro. Intramolecular autophosphorylation is stimulated by CENPE. Phosphorylated during mitosis and hyperphosphorylated in mitotically arrested cells. Phosphorylation at Ser-670 and Ser-1043 occurs at kinetochores upon mitotic entry with dephosphorylation at the onset of anaphase.9 Publications

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiO60566.
PaxDbiO60566.
PRIDEiO60566.

PTM databases

PhosphoSiteiO60566.

Expressioni

Tissue specificityi

Highly expressed in thymus followed by spleen. Preferentially expressed in tissues with a high mitotic index.1 Publication

Inductioni

Induced during mitosis.3 Publications

Gene expression databases

BgeeiO60566.
CleanExiHS_BUB1B.
ExpressionAtlasiO60566. baseline and differential.
GenevestigatoriO60566.

Organism-specific databases

HPAiHPA008419.

Interactioni

Subunit structurei

Interacts with CENPE, CENPF, mitosin, PLK1 and BUB3. Part of a complex containing BUB3, CDC20 and BUB1B. Interacts with anaphase-promoting complex/cyclosome (APC/C). Interacts with CASC5.11 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BUB3O436842EBI-1001438,EBI-1050987
CDC20Q1283415EBI-1001438,EBI-367462
CENPEQ022244EBI-1001438,EBI-1375040
KAT2BQ9283113EBI-1001438,EBI-477430
UBCP0CG483EBI-1001438,EBI-3390054

Protein-protein interaction databases

BioGridi107166. 60 interactions.
DIPiDIP-24203N.
IntActiO60566. 39 interactions.
MINTiMINT-2796866.

Structurei

Secondary structure

1
1050
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni26 – 283Combined sources
Helixi60 – 656Combined sources
Helixi75 – 8814Combined sources
Helixi94 – 963Combined sources
Helixi98 – 10811Combined sources
Turni109 – 1113Combined sources
Helixi113 – 1153Combined sources
Helixi119 – 13113Combined sources
Helixi135 – 14410Combined sources
Helixi152 – 16413Combined sources
Helixi168 – 18013Combined sources
Helixi186 – 21833Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WVIX-ray1.80A57-220[»]
3SI5X-ray2.20A/B57-220[»]
4GGDX-ray2.44C/D20-42[»]
ProteinModelPortaliO60566.
SMRiO60566. Positions 20-203, 720-1033.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60566.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 226165BUB1 N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini766 – 1050285Protein kinaseAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni152 – 18534Necessary for interaction with CASC5Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi111 – 1188Nuclear localization signalSequence Analysis
Motifi224 – 2329D-box

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi209 – 2157Poly-Glu

Domaini

The D-box targets the protein for rapid degradation by ubiquitin-dependent proteolysis during the transition from mitosis to interphase.Curated
The BUB1 N-terminal domain directs kinetochore localization and binding to BUB3.

Sequence similaritiesi

Contains 1 BUB1 N-terminal domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.Curated

Phylogenomic databases

eggNOGiNOG317001.
GeneTreeiENSGT00520000055622.
HOVERGENiHBG050748.
InParanoidiO60566.
KOiK06637.
OMAiATHSSGF.
OrthoDBiEOG7DFXCB.
PhylomeDBiO60566.
TreeFamiTF105456.

Family and domain databases

InterProiIPR015661. Bub1/Mad3.
IPR011009. Kinase-like_dom.
IPR013212. Mad3_BUB1_I.
IPR000719. Prot_kinase_dom.
[Graphical view]
PANTHERiPTHR14030. PTHR14030. 1 hit.
PfamiPF08311. Mad3_BUB1_I. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00777. Mad3_BUB1_I. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51489. BUB1_N. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O60566-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVKKEGGA LSEAMSLEGD EWELSKENVQ PLRQGRIMST LQGALAQESA
60 70 80 90 100
CNNTLQQQKR AFEYEIRFYT GNDPLDVWDR YISWTEQNYP QGGKESNMST
110 120 130 140 150
LLERAVEALQ GEKRYYSDPR FLNLWLKLGR LCNEPLDMYS YLHNQGIGVS
160 170 180 190 200
LAQFYISWAE EYEARENFRK ADAIFQEGIQ QKAEPLERLQ SQHRQFQARV
210 220 230 240 250
SRQTLLALEK EEEEEVFESS VPQRSTLAEL KSKGKKTARA PIIRVGGALK
260 270 280 290 300
APSQNRGLQN PFPQQMQNNS RITVFDENAD EASTAELSKP TVQPWIAPPM
310 320 330 340 350
PRAKENELQA GPWNTGRSLE HRPRGNTASL IAVPAVLPSF TPYVEETARQ
360 370 380 390 400
PVMTPCKIEP SINHILSTRK PGKEEGDPLQ RVQSHQQASE EKKEKMMYCK
410 420 430 440 450
EKIYAGVGEF SFEEIRAEVF RKKLKEQREA ELLTSAEKRA EMQKQIEEME
460 470 480 490 500
KKLKEIQTTQ QERTGDQQEE TMPTKETTKL QIASESQKIP GMTLSSSVCQ
510 520 530 540 550
VNCCARETSL AENIWQEQPH SKGPSVPFSI FDEFLLSEKK NKSPPADPPR
560 570 580 590 600
VLAQRRPLAV LKTSESITSN EDVSPDVCDE FTGIEPLSED AIITGFRNVT
610 620 630 640 650
ICPNPEDTCD FARAARFVST PFHEIMSLKD LPSDPERLLP EEDLDVKTSE
660 670 680 690 700
DQQTACGTIY SQTLSIKKLS PIIEDSREAT HSSGFSGSSA SVASTSSIKC
710 720 730 740 750
LQIPEKLELT NETSENPTQS PWCSQYRRQL LKSLPELSAS AELCIEDRPM
760 770 780 790 800
PKLEIEKEIE LGNEDYCIKR EYLICEDYKL FWVAPRNSAE LTVIKVSSQP
810 820 830 840 850
VPWDFYINLK LKERLNEDFD HFCSCYQYQD GCIVWHQYIN CFTLQDLLQH
860 870 880 890 900
SEYITHEITV LIIYNLLTIV EMLHKAEIVH GDLSPRCLIL RNRIHDPYDC
910 920 930 940 950
NKNNQALKIV DFSYSVDLRV QLDVFTLSGF RTVQILEGQK ILANCSSPYQ
960 970 980 990 1000
VDLFGIADLA HLLLFKEHLQ VFWDGSFWKL SQNISELKDG ELWNKFFVRI
1010 1020 1030 1040 1050
LNANDEATVS VLGELAAEMN GVFDTTFQSH LNKALWKVGK LTSPGALLFQ
Length:1,050
Mass (Da):119,545
Last modified:April 3, 2007 - v3
Checksum:iF7871103A56E6B46
GO
Isoform 2 (identifier: O60566-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-166: Missing.
     522-522: K → KVSLSL
     608-675: Missing.

Note: No experimental confirmation available.

Show »
Length:933
Mass (Da):105,890
Checksum:i81D1307E360D7B67
GO
Isoform 3 (identifier: O60566-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     80-80: R → RWVFLFHKDNRNINR

Note: No experimental confirmation available.

Show »
Length:1,064
Mass (Da):121,386
Checksum:iFB6C9F104164FBEB
GO

Sequence cautioni

The sequence BAD92019.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti248 – 2492AL → VF in AAC23736. (PubMed:9618306)Curated
Sequence conflicti283 – 2831S → P in BAG35587. (PubMed:14702039)Curated
Sequence conflicti788 – 7881S → F in AAC06260. (PubMed:9660858)Curated
Sequence conflicti1018 – 10181E → K in AAC33435. (PubMed:9763420)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151M → T in a colorectal cancer cell line. 1 Publication
VAR_008852
Natural varianti36 – 361R → Q in PCS. 1 Publication
VAR_028921
Natural varianti40 – 401T → M.1 Publication
Corresponds to variant rs56079734 [ dbSNP | Ensembl ].
VAR_040402
Natural varianti349 – 3491R → Q.9 Publications
Corresponds to variant rs1801376 [ dbSNP | Ensembl ].
VAR_008853
Natural varianti378 – 3781P → S.1 Publication
Corresponds to variant rs17851677 [ dbSNP | Ensembl ].
VAR_054549
Natural varianti390 – 3901E → D.1 Publication
Corresponds to variant rs1017842 [ dbSNP | Ensembl ].
VAR_028922
Natural varianti550 – 5501R → Q in MVA1; heterozygous compound with nonsense mutation. 1 Publication
Corresponds to variant rs28989187 [ dbSNP | Ensembl ].
VAR_028923
Natural varianti618 – 6181V → A in colorectal cancer. 2 Publications
Corresponds to variant rs1801528 [ dbSNP | Ensembl ].
VAR_008854
Natural varianti814 – 8141R → H in MVA1; heterozygous compound with nonsense mutation. 1 Publication
Corresponds to variant rs28989182 [ dbSNP | Ensembl ].
VAR_028924
Natural varianti844 – 8441L → F in MVA1; associated with H-921; heterozygous compound with nonsense mutation. 1 Publication
Corresponds to variant rs28989181 [ dbSNP | Ensembl ].
VAR_028925
Natural varianti909 – 9091I → T in MVA1; heterozygous compound with nonsense mutation. 1 Publication
Corresponds to variant rs28989184 [ dbSNP | Ensembl ].
VAR_028926
Natural varianti921 – 9211Q → H in MVA1; associated with F-844; heterozygous compound with nonsense mutation. 1 Publication
Corresponds to variant rs28989183 [ dbSNP | Ensembl ].
VAR_028927
Natural varianti1012 – 10121L → P in MVA1; heterozygous compound with nonsense mutation. 1 Publication
Corresponds to variant rs28989185 [ dbSNP | Ensembl ].
VAR_028928

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei80 – 801R → RWVFLFHKDNRNINR in isoform 3. 1 PublicationVSP_036473
Alternative sequencei113 – 16654Missing in isoform 2. 1 PublicationVSP_036474Add
BLAST
Alternative sequencei522 – 5221K → KVSLSL in isoform 2. 1 PublicationVSP_036475
Alternative sequencei608 – 67568Missing in isoform 2. 1 PublicationVSP_036476Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053306 mRNA. Translation: AAC06260.1.
AF046918 mRNA. Translation: AAC33435.1.
AF046079 mRNA. Translation: AAC12730.2.
AF107297 mRNA. Translation: AAD11941.1.
AF035933 mRNA. Translation: AAC23736.1.
AF068760 mRNA. Translation: AAC19118.1.
AF310214
, AF310192, AF310193, AF310194, AF310195, AF310196, AF310197, AF310198, AF310199, AF310200, AF310201, AF310202, AF310203, AF310204, AF310205, AF310206, AF310207, AF310208, AF310209, AF310210, AF310211, AF310212, AF310213 Genomic DNA. Translation: AAL10712.1.
AK296795 mRNA. Translation: BAG59371.1.
AK296984 mRNA. Translation: BAG59525.1.
AK312709 mRNA. Translation: BAG35587.1.
AB208782 mRNA. Translation: BAD92019.1. Different initiation.
BC018739 mRNA. Translation: AAH18739.1.
CCDSiCCDS10053.1. [O60566-1]
PIRiJW0092.
RefSeqiNP_001202.4. NM_001211.5.
UniGeneiHs.513645.

Genome annotation databases

EnsembliENST00000287598; ENSP00000287598; ENSG00000156970. [O60566-1]
ENST00000412359; ENSP00000398470; ENSG00000156970. [O60566-3]
GeneIDi701.
KEGGihsa:701.
UCSCiuc001zkx.4. human. [O60566-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053306 mRNA. Translation: AAC06260.1 .
AF046918 mRNA. Translation: AAC33435.1 .
AF046079 mRNA. Translation: AAC12730.2 .
AF107297 mRNA. Translation: AAD11941.1 .
AF035933 mRNA. Translation: AAC23736.1 .
AF068760 mRNA. Translation: AAC19118.1 .
AF310214
, AF310192 , AF310193 , AF310194 , AF310195 , AF310196 , AF310197 , AF310198 , AF310199 , AF310200 , AF310201 , AF310202 , AF310203 , AF310204 , AF310205 , AF310206 , AF310207 , AF310208 , AF310209 , AF310210 , AF310211 , AF310212 , AF310213 Genomic DNA. Translation: AAL10712.1 .
AK296795 mRNA. Translation: BAG59371.1 .
AK296984 mRNA. Translation: BAG59525.1 .
AK312709 mRNA. Translation: BAG35587.1 .
AB208782 mRNA. Translation: BAD92019.1 . Different initiation.
BC018739 mRNA. Translation: AAH18739.1 .
CCDSi CCDS10053.1. [O60566-1 ]
PIRi JW0092.
RefSeqi NP_001202.4. NM_001211.5.
UniGenei Hs.513645.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2WVI X-ray 1.80 A 57-220 [» ]
3SI5 X-ray 2.20 A/B 57-220 [» ]
4GGD X-ray 2.44 C/D 20-42 [» ]
ProteinModelPortali O60566.
SMRi O60566. Positions 20-203, 720-1033.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107166. 60 interactions.
DIPi DIP-24203N.
IntActi O60566. 39 interactions.
MINTi MINT-2796866.

PTM databases

PhosphoSitei O60566.

Proteomic databases

MaxQBi O60566.
PaxDbi O60566.
PRIDEi O60566.

Protocols and materials databases

DNASUi 701.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000287598 ; ENSP00000287598 ; ENSG00000156970 . [O60566-1 ]
ENST00000412359 ; ENSP00000398470 ; ENSG00000156970 . [O60566-3 ]
GeneIDi 701.
KEGGi hsa:701.
UCSCi uc001zkx.4. human. [O60566-1 ]

Organism-specific databases

CTDi 701.
GeneCardsi GC15P040453.
H-InvDB HIX0012121.
HGNCi HGNC:1149. BUB1B.
HPAi HPA008419.
MIMi 176430. phenotype.
257300. phenotype.
602860. gene.
neXtProti NX_O60566.
Orphaneti 1052. Mosaic variegated aneuploidy syndrome.
PharmGKBi PA82.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG317001.
GeneTreei ENSGT00520000055622.
HOVERGENi HBG050748.
InParanoidi O60566.
KOi K06637.
OMAi ATHSSGF.
OrthoDBi EOG7DFXCB.
PhylomeDBi O60566.
TreeFami TF105456.

Enzyme and pathway databases

BRENDAi 2.7.11.1. 2681.
Reactomei REACT_1072. Inactivation of APC/C via direct inhibition of the APC/C complex.
REACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_6781. APC/C:Cdc20 mediated degradation of mitotic proteins.
REACT_682. Mitotic Prometaphase.
SignaLinki O60566.

Miscellaneous databases

EvolutionaryTracei O60566.
GeneWikii BUB1B.
GenomeRNAii 701.
NextBioi 2866.
PROi O60566.
SOURCEi Search...

Gene expression databases

Bgeei O60566.
CleanExi HS_BUB1B.
ExpressionAtlasi O60566. baseline and differential.
Genevestigatori O60566.

Family and domain databases

InterProi IPR015661. Bub1/Mad3.
IPR011009. Kinase-like_dom.
IPR013212. Mad3_BUB1_I.
IPR000719. Prot_kinase_dom.
[Graphical view ]
PANTHERi PTHR14030. PTHR14030. 1 hit.
Pfami PF08311. Mad3_BUB1_I. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00777. Mad3_BUB1_I. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51489. BUB1_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel gene -- SSK1 -- in human endothelial cells exposed to shear stress."
    Donadelli R., Benatti L., Remuzzi A., Morigi M., Gullans S.R., Benigni A., Remuzzi G., Noris M.
    Biochem. Biophys. Res. Commun. 246:881-887(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLN-349.
    Tissue: Umbilical vein.
  2. "The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase."
    Taylor S.S., Ha E., McKeon F.
    J. Cell Biol. 142:1-11(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLN-349.
  3. "Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1."
    Chan G.K.T., Schaar B.T., Yen T.J.
    J. Cell Biol. 143:49-63(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH CENPE, SUBCELLULAR LOCATION, VARIANT GLN-349.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS THR-15 AND GLN-349.
  5. "The mouse mitotic checkpoint gene bub1b, a novel bub1 family member, is expressed in a cell cycle-dependent manner."
    Davenport J.W., Fernandes E.R., Harris L.D., Neale G.A.M., Goorha R.
    Genomics 55:113-117(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  6. "Human MAD3-like protein kinase (hmad3)."
    Dai W., Ouyang B., Lan Z., Pan H.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLN-349.
  7. Seike M., Gemma A., Hosoya Y., Kurimoto F., Yoshimura A., Kudoh S.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT GLN-349.
    Tissue: Tongue.
  9. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLN-349 AND SER-378.
    Tissue: Placenta.
  11. "BUBR1 phosphorylation is regulated during mitotic checkpoint activation."
    Li W., Lan Z., Wu H., Wu S., Meadows J., Chen J., Zhu V., Dai W.
    Cell Growth Differ. 10:769-775(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, TISSUE SPECIFICITY, INDUCTION.
  12. "Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC."
    Chan G.K., Jablonski S.A., Sudakin V., Hittle J.C., Yen T.J.
    J. Cell Biol. 146:941-954(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION, PHOSPHORYLATION, INTERACTION WITH APC/C.
  13. "Mad2-independent inhibition of APC/Cdc20 by the mitotic checkpoint protein BubR1."
    Tang Z., Bharadwaj R., Li B., Yu H.
    Dev. Cell 1:227-237(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN A COMPLEX WITH CDC20 AND BUB3, MUTAGENESIS OF LYS-795.
  14. "Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability."
    Shin H.J., Baek K.H., Jeon A.H., Park M.T., Lee S.J., Kang C.M., Lee H.S., Yoo S.H., Chung D.H., Sung Y.C., McKeon F., Lee C.W.
    Cancer Cell 4:483-497(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, DEGRADATION BY THE PROTEASOME.
  15. "Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss."
    Weaver B.A., Bonday Z.Q., Putkey F.R., Kops G.J., Silk A.D., Cleveland D.W.
    J. Cell Biol. 162:551-563(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYME REGULATION, INTERACTION WITH CENPE, AUTOPHOSPHORYLATION, MUTAGENESIS OF LYS-795.
  16. "Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression."
    Johnson V.L., Scott M.I., Holt S.V., Hussein D., Taylor S.S.
    J. Cell Sci. 117:1577-1589(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  17. "Caspase-mediated specific cleavage of BubR1 is a determinant of mitotic progression."
    Kim M., Murphy K., Liu F., Parker S.E., Dowling M.L., Baff W., Kao G.D.
    Mol. Cell. Biol. 25:9232-9248(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: CASPASE-3 CLEAVAGE AT ASP-579 AND ASP-610, INDUCTION, MUTAGENESIS OF ASP-579 AND ASP-610.
  18. "Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1."
    Qi W., Tang Z., Yu H.
    Mol. Biol. Cell 17:3705-3716(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH PLK1.
  19. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  20. "Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1."
    Kiyomitsu T., Obuse C., Yanagida M.
    Dev. Cell 13:663-676(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CASC5, MUTAGENESIS OF ALA-159 AND PHE-175.
  21. "Tension-sensitive Plk1 phosphorylation on BubR1 regulates the stability of kinetochore microtubule interactions."
    Elowe S., Huemmer S., Uldschmid A., Li X., Nigg E.A.
    Genes Dev. 21:2205-2219(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PLK1, SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-676, MUTAGENESIS OF THR-620.
  22. "Polo-like kinase 1 facilitates chromosome alignment during prometaphase through BubR1."
    Matsumura S., Toyoshima F., Nishida E.
    J. Biol. Chem. 282:15217-15227(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PLK1, SUBCELLULAR LOCATION, PHOSPHORYLATION AT THR-792 AND THR-1008.
  23. "Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit."
    Huang H., Hittle J., Zappacosta F., Annan R.S., Hershko A., Yen T.J.
    J. Cell Biol. 183:667-680(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-435; SER-543; SER-670 AND SER-1043.
  24. "SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis."
    Zhang X.-D., Goeres J., Zhang H., Yen T.J., Porter A.C.G., Matunis M.J.
    Mol. Cell 29:729-741(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION.
  25. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-670, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  26. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-670, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  27. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  28. "Depletion of BubR1 promotes premature centrosomal localization of cyclin B1 and accelerates mitotic entry."
    Park S.-Y., Kim S., Cho H., Kwon S.-H., Chae S., Kang D., Seong Y.-S., Cho H.
    Cell Cycle 8:1754-1764(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  29. "Defects in chromosome congression and mitotic progression in KIF18A-deficient cells are partly mediated through impaired functions of CENP-E."
    Huang Y., Yao Y., Xu H.-Z., Wang Z.-G., Lu L., Dai W.
    Cell Cycle 8:2643-2649(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CENPE, SUBCELLULAR LOCATION.
  30. "BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis."
    Choi E., Choe H., Min J., Choi J.Y., Kim J., Lee H.
    EMBO J. 28:2077-2089(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PCAF, ACETYLATION AT LYS-250, UBIQUITINATION.
  31. "BubR1 localizes to centrosomes and suppresses centrosome amplification via regulating Plk1 activity in interphase cells."
    Izumi H., Matsumoto Y., Ikeuchi T., Saya H., Kajii T., Matsuura S.
    Oncogene 28:2806-2820(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PLK1.
  32. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-670 AND THR-1042, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  33. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  34. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-543, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  35. "Characterization of MAD2B and other mitotic spindle checkpoint genes."
    Cahill D.P., da Costa L.T., Carson-Walter E.B., Kinzler K.W., Vogelstein B., Lengauer C.
    Genomics 58:181-187(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS GLN-349 AND ALA-618.
  36. Cited for: VARIANTS MVA1 GLN-550; HIS-814; PHE-844; THR-909; HIS-921 AND PRO-1012.
  37. "Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome."
    Matsuura S., Matsumoto Y., Morishima K., Izumi H., Matsumoto H., Ito E., Tsutsui K., Kobayashi J., Tauchi H., Kajiwara Y., Hama S., Kurisu K., Tahara H., Oshimura M., Komatsu K., Ikeuchi T., Kajii T.
    Am. J. Med. Genet. A 140:358-367(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT PCS GLN-36.
  38. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] MET-40; GLN-349; ASP-390 AND ALA-618.

Entry informationi

Entry nameiBUB1B_HUMAN
AccessioniPrimary (citable) accession number: O60566
Secondary accession number(s): B2R6U0
, B4DL09, B4DLG3, O60501, O60627, O60758, O75389, Q59HH6, Q8WV50, Q96KM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 3, 2007
Last modified: November 26, 2014
This is version 152 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3