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O60566

- BUB1B_HUMAN

UniProt

O60566 - BUB1B_HUMAN

Protein

Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Gene

BUB1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 150 (01 Oct 2014)
      Sequence version 3 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.6 Publications

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Kinase activity stimulated by CENPE.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei579 – 5802Cleavage; by caspase-3
    Sitei610 – 6112Cleavage; by caspase-3
    Binding sitei795 – 7951ATPBy similarity
    Active sitei882 – 8821Proton acceptorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi772 – 7809ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: UniProtKB
    3. protein kinase activity Source: UniProtKB
    4. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Source: Reactome
    2. apoptotic process Source: UniProtKB-KW
    3. cell cycle Source: UniProtKB
    4. cell proliferation Source: ProtInc
    5. metaphase/anaphase transition of mitotic cell cycle Source: Ensembl
    6. mitotic cell cycle Source: Reactome
    7. mitotic cell cycle checkpoint Source: ProtInc
    8. mitotic nuclear division Source: UniProtKB
    9. mitotic spindle assembly checkpoint Source: Reactome
    10. negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
    11. phosphatidylinositol-mediated signaling Source: UniProtKB
    12. protein localization to chromosome, centromeric region Source: Ensembl
    13. protein localization to kinetochore Source: UniProtKB
    14. regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
    15. spindle organization Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Apoptosis, Cell cycle, Cell division, Mitosis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.1. 2681.
    ReactomeiREACT_1072. Inactivation of APC/C via direct inhibition of the APC/C complex.
    REACT_150425. Resolution of Sister Chromatid Cohesion.
    REACT_150471. Separation of Sister Chromatids.
    REACT_6781. APC/C:Cdc20 mediated degradation of mitotic proteins.
    REACT_682. Mitotic Prometaphase.
    SignaLinkiO60566.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC:2.7.11.1)
    Alternative name(s):
    MAD3/BUB1-related protein kinase
    Short name:
    hBUBR1
    Mitotic checkpoint kinase MAD3L
    Protein SSK1
    Gene namesi
    Name:BUB1B
    Synonyms:BUBR1, MAD3L, SSK1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:1149. BUB1B.

    Subcellular locationi

    Cytoplasm. Nucleus. Chromosomecentromerekinetochore. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome
    Note: Cytoplasmic in interphase cells. Associates with the kinetochores in early prophase. Kinetochore localization requires BUB1, PLK1 and CASC5.

    GO - Cellular componenti

    1. anaphase-promoting complex Source: ProtInc
    2. condensed chromosome kinetochore Source: UniProtKB
    3. condensed chromosome outer kinetochore Source: UniProtKB
    4. condensed nuclear chromosome kinetochore Source: Ensembl
    5. cytoplasm Source: LIFEdb
    6. cytosol Source: Reactome
    7. kinetochore Source: UniProtKB
    8. microtubule organizing center Source: UniProtKB-SubCell
    9. perinuclear region of cytoplasm Source: BHF-UCL
    10. spindle midzone Source: UniProtKB

    Keywords - Cellular componenti

    Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Defects in BUB1B are associated with tumor formation.
    Premature chromatid separation trait (PCS) [MIM:176430]: Consists of separate and splayed chromatids with discernible centromeres and involves all or most chromosomes of a metaphase. It is found in up to 2% of metaphases in cultured lymphocytes from approximately 40% of normal individuals. When PCS is present in 5% or more of cells, it is known as the heterozygous PCS trait and has no obvious phenotypic effect, although some have reported decreased fertility. Inheritance is autosomal dominant.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti36 – 361R → Q in PCS. 1 Publication
    VAR_028921
    Mosaic variegated aneuploidy syndrome 1 (MVA1) [MIM:257300]: A severe developmental disorder characterized by mosaic aneuploidies, predominantly trisomies and monosomies, involving multiple different chromosomes and tissues. Affected individuals typically present with severe intrauterine growth retardation and microcephaly. Eye anomalies, mild dysmorphism, variable developmental delay, and a broad spectrum of additional congenital abnormalities and medical conditions may also occur. The risk of malignancy is high, with rhabdomyosarcoma, Wilms tumor and leukemia reported in several cases.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry. MVA1 is caused by biallelic mutations in the BUB1B gene.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti550 – 5501R → Q in MVA1; heterozygous compound with nonsense mutation. 1 Publication
    Corresponds to variant rs28989187 [ dbSNP | Ensembl ].
    VAR_028923
    Natural varianti814 – 8141R → H in MVA1; heterozygous compound with nonsense mutation. 1 Publication
    Corresponds to variant rs28989182 [ dbSNP | Ensembl ].
    VAR_028924
    Natural varianti844 – 8441L → F in MVA1; associated with H-921; heterozygous compound with nonsense mutation. 1 Publication
    Corresponds to variant rs28989181 [ dbSNP | Ensembl ].
    VAR_028925
    Natural varianti909 – 9091I → T in MVA1; heterozygous compound with nonsense mutation. 1 Publication
    Corresponds to variant rs28989184 [ dbSNP | Ensembl ].
    VAR_028926
    Natural varianti921 – 9211Q → H in MVA1; associated with F-844; heterozygous compound with nonsense mutation. 1 Publication
    Corresponds to variant rs28989183 [ dbSNP | Ensembl ].
    VAR_028927
    Natural varianti1012 – 10121L → P in MVA1; heterozygous compound with nonsense mutation. 1 Publication
    Corresponds to variant rs28989185 [ dbSNP | Ensembl ].
    VAR_028928

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi159 – 1591A → W: Loss of interaction with CASC5. 1 Publication
    Mutagenesisi175 – 1751F → A: Loss of interaction with CASC5. 1 Publication
    Mutagenesisi579 – 5791D → E: Abolishes the cleavage by caspase-3. 1 Publication
    Mutagenesisi610 – 6101D → E: Abolishes the cleavage by caspase-3. 1 Publication
    Mutagenesisi620 – 6201T → A: Induces chromosome congression defects and mitotic delay. 1 Publication
    Mutagenesisi795 – 7951K → A: Does not abolish the capacity to inhibit APC/CDC20. 2 Publications
    Mutagenesisi795 – 7951K → R: Inhibits kinase activity. 2 Publications

    Keywords - Diseasei

    Disease mutation, Tumor suppressor

    Organism-specific databases

    MIMi176430. phenotype.
    257300. phenotype.
    Orphaneti1052. Mosaic variegated aneuploidy syndrome.
    PharmGKBiPA82.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10501050Mitotic checkpoint serine/threonine-protein kinase BUB1 betaPRO_0000085673Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei250 – 2501N6-acetyllysine; by PCAF1 Publication
    Modified residuei435 – 4351Phosphoserine1 Publication
    Modified residuei543 – 5431Phosphoserine2 Publications
    Modified residuei670 – 6701Phosphoserine4 Publications
    Modified residuei676 – 6761Phosphoserine; by PLK11 Publication
    Modified residuei792 – 7921Phosphothreonine; by PLK11 Publication
    Modified residuei1008 – 10081Phosphothreonine; by PLK11 Publication
    Modified residuei1042 – 10421Phosphothreonine1 Publication
    Modified residuei1043 – 10431Phosphoserine1 Publication

    Post-translational modificationi

    Proteolytically cleaved by caspase-3 in a cell cycle specific manner. The cleavage might be involved in the durability of the cell cycle delay. Caspase-3 cleavage is associated with abrogation of the mitotic checkpoint. The major site of cleavage is at Asp-610.
    Acetylation at Lys-250 regulates its degradation and timing in anaphase entry.1 Publication
    Ubiquitinated. Degraded by the proteasome.1 Publication
    Sumoylated with SUMO2 and SUMO3. The sumoylation mediates the association with CENPE at the kinetochore.1 Publication
    Autophosphorylated in vitro. Intramolecular autophosphorylation is stimulated by CENPE. Phosphorylated during mitosis and hyperphosphorylated in mitotically arrested cells. Phosphorylation at Ser-670 and Ser-1043 occurs at kinetochores upon mitotic entry with dephosphorylation at the onset of anaphase.9 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiO60566.
    PaxDbiO60566.
    PRIDEiO60566.

    PTM databases

    PhosphoSiteiO60566.

    Expressioni

    Tissue specificityi

    Highly expressed in thymus followed by spleen. Preferentially expressed in tissues with a high mitotic index.1 Publication

    Inductioni

    Induced during mitosis.3 Publications

    Gene expression databases

    ArrayExpressiO60566.
    BgeeiO60566.
    CleanExiHS_BUB1B.
    GenevestigatoriO60566.

    Organism-specific databases

    HPAiHPA008419.

    Interactioni

    Subunit structurei

    Interacts with CENPE, CENPF, mitosin, PLK1 and BUB3. Part of a complex containing BUB3, CDC20 and BUB1B. Interacts with anaphase-promoting complex/cyclosome (APC/C). Interacts with CASC5.11 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BUB3O436842EBI-1001438,EBI-1050987
    CDC20Q1283415EBI-1001438,EBI-367462
    CENPEQ022244EBI-1001438,EBI-1375040
    KAT2BQ9283113EBI-1001438,EBI-477430
    UBCP0CG483EBI-1001438,EBI-3390054

    Protein-protein interaction databases

    BioGridi107166. 58 interactions.
    DIPiDIP-24203N.
    IntActiO60566. 39 interactions.
    MINTiMINT-2796866.

    Structurei

    Secondary structure

    1
    1050
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni26 – 283
    Helixi60 – 656
    Helixi75 – 8814
    Helixi94 – 963
    Helixi98 – 10811
    Turni109 – 1113
    Helixi113 – 1153
    Helixi119 – 13113
    Helixi135 – 14410
    Helixi152 – 16413
    Helixi168 – 18013
    Helixi186 – 21833

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2WVIX-ray1.80A57-220[»]
    3SI5X-ray2.20A/B57-220[»]
    4GGDX-ray2.44C/D20-42[»]
    ProteinModelPortaliO60566.
    SMRiO60566. Positions 20-203, 720-1033.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO60566.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini62 – 226165BUB1 N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini766 – 1050285Protein kinaseAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni152 – 18534Necessary for interaction with CASC5Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi111 – 1188Nuclear localization signalSequence Analysis
    Motifi224 – 2329D-box

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi209 – 2157Poly-Glu

    Domaini

    The D-box targets the protein for rapid degradation by ubiquitin-dependent proteolysis during the transition from mitosis to interphase.Curated
    The BUB1 N-terminal domain directs kinetochore localization and binding to BUB3.

    Sequence similaritiesi

    Contains 1 BUB1 N-terminal domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.Curated

    Phylogenomic databases

    eggNOGiNOG317001.
    HOVERGENiHBG050748.
    InParanoidiO60566.
    KOiK06637.
    OMAiATHSSGF.
    OrthoDBiEOG7DFXCB.
    PhylomeDBiO60566.
    TreeFamiTF105456.

    Family and domain databases

    InterProiIPR015661. Bub1/Mad3.
    IPR011009. Kinase-like_dom.
    IPR013212. Mad3_BUB1_I.
    IPR000719. Prot_kinase_dom.
    [Graphical view]
    PANTHERiPTHR14030. PTHR14030. 1 hit.
    PfamiPF08311. Mad3_BUB1_I. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00777. Mad3_BUB1_I. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51489. BUB1_N. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O60566-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAVKKEGGA LSEAMSLEGD EWELSKENVQ PLRQGRIMST LQGALAQESA     50
    CNNTLQQQKR AFEYEIRFYT GNDPLDVWDR YISWTEQNYP QGGKESNMST 100
    LLERAVEALQ GEKRYYSDPR FLNLWLKLGR LCNEPLDMYS YLHNQGIGVS 150
    LAQFYISWAE EYEARENFRK ADAIFQEGIQ QKAEPLERLQ SQHRQFQARV 200
    SRQTLLALEK EEEEEVFESS VPQRSTLAEL KSKGKKTARA PIIRVGGALK 250
    APSQNRGLQN PFPQQMQNNS RITVFDENAD EASTAELSKP TVQPWIAPPM 300
    PRAKENELQA GPWNTGRSLE HRPRGNTASL IAVPAVLPSF TPYVEETARQ 350
    PVMTPCKIEP SINHILSTRK PGKEEGDPLQ RVQSHQQASE EKKEKMMYCK 400
    EKIYAGVGEF SFEEIRAEVF RKKLKEQREA ELLTSAEKRA EMQKQIEEME 450
    KKLKEIQTTQ QERTGDQQEE TMPTKETTKL QIASESQKIP GMTLSSSVCQ 500
    VNCCARETSL AENIWQEQPH SKGPSVPFSI FDEFLLSEKK NKSPPADPPR 550
    VLAQRRPLAV LKTSESITSN EDVSPDVCDE FTGIEPLSED AIITGFRNVT 600
    ICPNPEDTCD FARAARFVST PFHEIMSLKD LPSDPERLLP EEDLDVKTSE 650
    DQQTACGTIY SQTLSIKKLS PIIEDSREAT HSSGFSGSSA SVASTSSIKC 700
    LQIPEKLELT NETSENPTQS PWCSQYRRQL LKSLPELSAS AELCIEDRPM 750
    PKLEIEKEIE LGNEDYCIKR EYLICEDYKL FWVAPRNSAE LTVIKVSSQP 800
    VPWDFYINLK LKERLNEDFD HFCSCYQYQD GCIVWHQYIN CFTLQDLLQH 850
    SEYITHEITV LIIYNLLTIV EMLHKAEIVH GDLSPRCLIL RNRIHDPYDC 900
    NKNNQALKIV DFSYSVDLRV QLDVFTLSGF RTVQILEGQK ILANCSSPYQ 950
    VDLFGIADLA HLLLFKEHLQ VFWDGSFWKL SQNISELKDG ELWNKFFVRI 1000
    LNANDEATVS VLGELAAEMN GVFDTTFQSH LNKALWKVGK LTSPGALLFQ 1050
    Length:1,050
    Mass (Da):119,545
    Last modified:April 3, 2007 - v3
    Checksum:iF7871103A56E6B46
    GO
    Isoform 2 (identifier: O60566-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         113-166: Missing.
         522-522: K → KVSLSL
         608-675: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:933
    Mass (Da):105,890
    Checksum:i81D1307E360D7B67
    GO
    Isoform 3 (identifier: O60566-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         80-80: R → RWVFLFHKDNRNINR

    Note: No experimental confirmation available.

    Show »
    Length:1,064
    Mass (Da):121,386
    Checksum:iFB6C9F104164FBEB
    GO

    Sequence cautioni

    The sequence BAD92019.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti248 – 2492AL → VF in AAC23736. (PubMed:9618306)Curated
    Sequence conflicti283 – 2831S → P in BAG35587. (PubMed:14702039)Curated
    Sequence conflicti788 – 7881S → F in AAC06260. (PubMed:9660858)Curated
    Sequence conflicti1018 – 10181E → K in AAC33435. (PubMed:9763420)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti15 – 151M → T in a colorectal cancer cell line. 1 Publication
    VAR_008852
    Natural varianti36 – 361R → Q in PCS. 1 Publication
    VAR_028921
    Natural varianti40 – 401T → M.1 Publication
    Corresponds to variant rs56079734 [ dbSNP | Ensembl ].
    VAR_040402
    Natural varianti349 – 3491R → Q.9 Publications
    Corresponds to variant rs1801376 [ dbSNP | Ensembl ].
    VAR_008853
    Natural varianti378 – 3781P → S.1 Publication
    Corresponds to variant rs17851677 [ dbSNP | Ensembl ].
    VAR_054549
    Natural varianti390 – 3901E → D.1 Publication
    Corresponds to variant rs1017842 [ dbSNP | Ensembl ].
    VAR_028922
    Natural varianti550 – 5501R → Q in MVA1; heterozygous compound with nonsense mutation. 1 Publication
    Corresponds to variant rs28989187 [ dbSNP | Ensembl ].
    VAR_028923
    Natural varianti618 – 6181V → A in colorectal cancer. 2 Publications
    Corresponds to variant rs1801528 [ dbSNP | Ensembl ].
    VAR_008854
    Natural varianti814 – 8141R → H in MVA1; heterozygous compound with nonsense mutation. 1 Publication
    Corresponds to variant rs28989182 [ dbSNP | Ensembl ].
    VAR_028924
    Natural varianti844 – 8441L → F in MVA1; associated with H-921; heterozygous compound with nonsense mutation. 1 Publication
    Corresponds to variant rs28989181 [ dbSNP | Ensembl ].
    VAR_028925
    Natural varianti909 – 9091I → T in MVA1; heterozygous compound with nonsense mutation. 1 Publication
    Corresponds to variant rs28989184 [ dbSNP | Ensembl ].
    VAR_028926
    Natural varianti921 – 9211Q → H in MVA1; associated with F-844; heterozygous compound with nonsense mutation. 1 Publication
    Corresponds to variant rs28989183 [ dbSNP | Ensembl ].
    VAR_028927
    Natural varianti1012 – 10121L → P in MVA1; heterozygous compound with nonsense mutation. 1 Publication
    Corresponds to variant rs28989185 [ dbSNP | Ensembl ].
    VAR_028928

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei80 – 801R → RWVFLFHKDNRNINR in isoform 3. 1 PublicationVSP_036473
    Alternative sequencei113 – 16654Missing in isoform 2. 1 PublicationVSP_036474Add
    BLAST
    Alternative sequencei522 – 5221K → KVSLSL in isoform 2. 1 PublicationVSP_036475
    Alternative sequencei608 – 67568Missing in isoform 2. 1 PublicationVSP_036476Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF053306 mRNA. Translation: AAC06260.1.
    AF046918 mRNA. Translation: AAC33435.1.
    AF046079 mRNA. Translation: AAC12730.2.
    AF107297 mRNA. Translation: AAD11941.1.
    AF035933 mRNA. Translation: AAC23736.1.
    AF068760 mRNA. Translation: AAC19118.1.
    AF310214
    , AF310192, AF310193, AF310194, AF310195, AF310196, AF310197, AF310198, AF310199, AF310200, AF310201, AF310202, AF310203, AF310204, AF310205, AF310206, AF310207, AF310208, AF310209, AF310210, AF310211, AF310212, AF310213 Genomic DNA. Translation: AAL10712.1.
    AK296795 mRNA. Translation: BAG59371.1.
    AK296984 mRNA. Translation: BAG59525.1.
    AK312709 mRNA. Translation: BAG35587.1.
    AB208782 mRNA. Translation: BAD92019.1. Different initiation.
    BC018739 mRNA. Translation: AAH18739.1.
    CCDSiCCDS10053.1. [O60566-1]
    PIRiJW0092.
    RefSeqiNP_001202.4. NM_001211.5.
    UniGeneiHs.513645.

    Genome annotation databases

    EnsembliENST00000287598; ENSP00000287598; ENSG00000156970. [O60566-1]
    ENST00000412359; ENSP00000398470; ENSG00000156970. [O60566-3]
    GeneIDi701.
    KEGGihsa:701.
    UCSCiuc001zkx.4. human. [O60566-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF053306 mRNA. Translation: AAC06260.1 .
    AF046918 mRNA. Translation: AAC33435.1 .
    AF046079 mRNA. Translation: AAC12730.2 .
    AF107297 mRNA. Translation: AAD11941.1 .
    AF035933 mRNA. Translation: AAC23736.1 .
    AF068760 mRNA. Translation: AAC19118.1 .
    AF310214
    , AF310192 , AF310193 , AF310194 , AF310195 , AF310196 , AF310197 , AF310198 , AF310199 , AF310200 , AF310201 , AF310202 , AF310203 , AF310204 , AF310205 , AF310206 , AF310207 , AF310208 , AF310209 , AF310210 , AF310211 , AF310212 , AF310213 Genomic DNA. Translation: AAL10712.1 .
    AK296795 mRNA. Translation: BAG59371.1 .
    AK296984 mRNA. Translation: BAG59525.1 .
    AK312709 mRNA. Translation: BAG35587.1 .
    AB208782 mRNA. Translation: BAD92019.1 . Different initiation.
    BC018739 mRNA. Translation: AAH18739.1 .
    CCDSi CCDS10053.1. [O60566-1 ]
    PIRi JW0092.
    RefSeqi NP_001202.4. NM_001211.5.
    UniGenei Hs.513645.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2WVI X-ray 1.80 A 57-220 [» ]
    3SI5 X-ray 2.20 A/B 57-220 [» ]
    4GGD X-ray 2.44 C/D 20-42 [» ]
    ProteinModelPortali O60566.
    SMRi O60566. Positions 20-203, 720-1033.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107166. 58 interactions.
    DIPi DIP-24203N.
    IntActi O60566. 39 interactions.
    MINTi MINT-2796866.

    PTM databases

    PhosphoSitei O60566.

    Proteomic databases

    MaxQBi O60566.
    PaxDbi O60566.
    PRIDEi O60566.

    Protocols and materials databases

    DNASUi 701.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000287598 ; ENSP00000287598 ; ENSG00000156970 . [O60566-1 ]
    ENST00000412359 ; ENSP00000398470 ; ENSG00000156970 . [O60566-3 ]
    GeneIDi 701.
    KEGGi hsa:701.
    UCSCi uc001zkx.4. human. [O60566-1 ]

    Organism-specific databases

    CTDi 701.
    GeneCardsi GC15P040453.
    H-InvDB HIX0012121.
    HGNCi HGNC:1149. BUB1B.
    HPAi HPA008419.
    MIMi 176430. phenotype.
    257300. phenotype.
    602860. gene.
    neXtProti NX_O60566.
    Orphaneti 1052. Mosaic variegated aneuploidy syndrome.
    PharmGKBi PA82.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG317001.
    HOVERGENi HBG050748.
    InParanoidi O60566.
    KOi K06637.
    OMAi ATHSSGF.
    OrthoDBi EOG7DFXCB.
    PhylomeDBi O60566.
    TreeFami TF105456.

    Enzyme and pathway databases

    BRENDAi 2.7.11.1. 2681.
    Reactomei REACT_1072. Inactivation of APC/C via direct inhibition of the APC/C complex.
    REACT_150425. Resolution of Sister Chromatid Cohesion.
    REACT_150471. Separation of Sister Chromatids.
    REACT_6781. APC/C:Cdc20 mediated degradation of mitotic proteins.
    REACT_682. Mitotic Prometaphase.
    SignaLinki O60566.

    Miscellaneous databases

    EvolutionaryTracei O60566.
    GeneWikii BUB1B.
    GenomeRNAii 701.
    NextBioi 2866.
    PROi O60566.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60566.
    Bgeei O60566.
    CleanExi HS_BUB1B.
    Genevestigatori O60566.

    Family and domain databases

    InterProi IPR015661. Bub1/Mad3.
    IPR011009. Kinase-like_dom.
    IPR013212. Mad3_BUB1_I.
    IPR000719. Prot_kinase_dom.
    [Graphical view ]
    PANTHERi PTHR14030. PTHR14030. 1 hit.
    Pfami PF08311. Mad3_BUB1_I. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00777. Mad3_BUB1_I. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51489. BUB1_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel gene -- SSK1 -- in human endothelial cells exposed to shear stress."
      Donadelli R., Benatti L., Remuzzi A., Morigi M., Gullans S.R., Benigni A., Remuzzi G., Noris M.
      Biochem. Biophys. Res. Commun. 246:881-887(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLN-349.
      Tissue: Umbilical vein.
    2. "The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase."
      Taylor S.S., Ha E., McKeon F.
      J. Cell Biol. 142:1-11(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLN-349.
    3. "Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1."
      Chan G.K.T., Schaar B.T., Yen T.J.
      J. Cell Biol. 143:49-63(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH CENPE, SUBCELLULAR LOCATION, VARIANT GLN-349.
    4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS THR-15 AND GLN-349.
    5. "The mouse mitotic checkpoint gene bub1b, a novel bub1 family member, is expressed in a cell cycle-dependent manner."
      Davenport J.W., Fernandes E.R., Harris L.D., Neale G.A.M., Goorha R.
      Genomics 55:113-117(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    6. "Human MAD3-like protein kinase (hmad3)."
      Dai W., Ouyang B., Lan Z., Pan H.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLN-349.
    7. Seike M., Gemma A., Hosoya Y., Kurimoto F., Yoshimura A., Kudoh S.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT GLN-349.
      Tissue: Tongue.
    9. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLN-349 AND SER-378.
      Tissue: Placenta.
    11. "BUBR1 phosphorylation is regulated during mitotic checkpoint activation."
      Li W., Lan Z., Wu H., Wu S., Meadows J., Chen J., Zhu V., Dai W.
      Cell Growth Differ. 10:769-775(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION, TISSUE SPECIFICITY, INDUCTION.
    12. "Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC."
      Chan G.K., Jablonski S.A., Sudakin V., Hittle J.C., Yen T.J.
      J. Cell Biol. 146:941-954(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION, PHOSPHORYLATION, INTERACTION WITH APC/C.
    13. "Mad2-independent inhibition of APC/Cdc20 by the mitotic checkpoint protein BubR1."
      Tang Z., Bharadwaj R., Li B., Yu H.
      Dev. Cell 1:227-237(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN A COMPLEX WITH CDC20 AND BUB3, MUTAGENESIS OF LYS-795.
    14. "Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability."
      Shin H.J., Baek K.H., Jeon A.H., Park M.T., Lee S.J., Kang C.M., Lee H.S., Yoo S.H., Chung D.H., Sung Y.C., McKeon F., Lee C.W.
      Cancer Cell 4:483-497(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, DEGRADATION BY THE PROTEASOME.
    15. "Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss."
      Weaver B.A., Bonday Z.Q., Putkey F.R., Kops G.J., Silk A.D., Cleveland D.W.
      J. Cell Biol. 162:551-563(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION, INTERACTION WITH CENPE, AUTOPHOSPHORYLATION, MUTAGENESIS OF LYS-795.
    16. "Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression."
      Johnson V.L., Scott M.I., Holt S.V., Hussein D., Taylor S.S.
      J. Cell Sci. 117:1577-1589(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    17. "Caspase-mediated specific cleavage of BubR1 is a determinant of mitotic progression."
      Kim M., Murphy K., Liu F., Parker S.E., Dowling M.L., Baff W., Kao G.D.
      Mol. Cell. Biol. 25:9232-9248(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: CASPASE-3 CLEAVAGE AT ASP-579 AND ASP-610, INDUCTION, MUTAGENESIS OF ASP-579 AND ASP-610.
    18. "Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1."
      Qi W., Tang Z., Yu H.
      Mol. Biol. Cell 17:3705-3716(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH PLK1.
    19. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    20. "Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1."
      Kiyomitsu T., Obuse C., Yanagida M.
      Dev. Cell 13:663-676(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CASC5, MUTAGENESIS OF ALA-159 AND PHE-175.
    21. "Tension-sensitive Plk1 phosphorylation on BubR1 regulates the stability of kinetochore microtubule interactions."
      Elowe S., Huemmer S., Uldschmid A., Li X., Nigg E.A.
      Genes Dev. 21:2205-2219(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PLK1, SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-676, MUTAGENESIS OF THR-620.
    22. "Polo-like kinase 1 facilitates chromosome alignment during prometaphase through BubR1."
      Matsumura S., Toyoshima F., Nishida E.
      J. Biol. Chem. 282:15217-15227(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PLK1, SUBCELLULAR LOCATION, PHOSPHORYLATION AT THR-792 AND THR-1008.
    23. "Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit."
      Huang H., Hittle J., Zappacosta F., Annan R.S., Hershko A., Yen T.J.
      J. Cell Biol. 183:667-680(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-435; SER-543; SER-670 AND SER-1043.
    24. "SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis."
      Zhang X.-D., Goeres J., Zhang H., Yen T.J., Porter A.C.G., Matunis M.J.
      Mol. Cell 29:729-741(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUMOYLATION.
    25. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-670, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    26. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-670, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    27. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    28. "Depletion of BubR1 promotes premature centrosomal localization of cyclin B1 and accelerates mitotic entry."
      Park S.-Y., Kim S., Cho H., Kwon S.-H., Chae S., Kang D., Seong Y.-S., Cho H.
      Cell Cycle 8:1754-1764(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    29. "Defects in chromosome congression and mitotic progression in KIF18A-deficient cells are partly mediated through impaired functions of CENP-E."
      Huang Y., Yao Y., Xu H.-Z., Wang Z.-G., Lu L., Dai W.
      Cell Cycle 8:2643-2649(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CENPE, SUBCELLULAR LOCATION.
    30. "BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis."
      Choi E., Choe H., Min J., Choi J.Y., Kim J., Lee H.
      EMBO J. 28:2077-2089(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PCAF, ACETYLATION AT LYS-250, UBIQUITINATION.
    31. "BubR1 localizes to centrosomes and suppresses centrosome amplification via regulating Plk1 activity in interphase cells."
      Izumi H., Matsumoto Y., Ikeuchi T., Saya H., Kajii T., Matsuura S.
      Oncogene 28:2806-2820(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PLK1.
    32. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-670 AND THR-1042, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    33. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    34. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-543, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    35. "Characterization of MAD2B and other mitotic spindle checkpoint genes."
      Cahill D.P., da Costa L.T., Carson-Walter E.B., Kinzler K.W., Vogelstein B., Lengauer C.
      Genomics 58:181-187(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS GLN-349 AND ALA-618.
    36. Cited for: VARIANTS MVA1 GLN-550; HIS-814; PHE-844; THR-909; HIS-921 AND PRO-1012.
    37. "Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome."
      Matsuura S., Matsumoto Y., Morishima K., Izumi H., Matsumoto H., Ito E., Tsutsui K., Kobayashi J., Tauchi H., Kajiwara Y., Hama S., Kurisu K., Tahara H., Oshimura M., Komatsu K., Ikeuchi T., Kajii T.
      Am. J. Med. Genet. A 140:358-367(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT PCS GLN-36.
    38. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] MET-40; GLN-349; ASP-390 AND ALA-618.

    Entry informationi

    Entry nameiBUB1B_HUMAN
    AccessioniPrimary (citable) accession number: O60566
    Secondary accession number(s): B2R6U0
    , B4DL09, B4DLG3, O60501, O60627, O60758, O75389, Q59HH6, Q8WV50, Q96KM4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 150 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3