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O60551

- NMT2_HUMAN

UniProt

O60551 - NMT2_HUMAN

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Protein

Glycylpeptide N-tetradecanoyltransferase 2

Gene
NMT2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Catalytic activityi

Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.

GO - Molecular functioni

  1. catalytic activity Source: ProtInc
  2. glycylpeptide N-tetradecanoyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. intracellular transport of virus Source: Reactome
  2. N-terminal protein myristoylation Source: InterPro
  3. phototransduction, visible light Source: Reactome
  4. protein lipoylation Source: ProtInc
  5. regulation of rhodopsin mediated signaling pathway Source: Reactome
  6. rhodopsin mediated signaling pathway Source: Reactome
  7. viral process Source: Reactome
  8. viral protein processing Source: Reactome
  9. virion assembly Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.3.1.97. 2681.
ReactomeiREACT_115893. Membrane binding and targetting of GAG proteins.
REACT_163919. Inactivation, recovery and regulation of the phototransduction cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycylpeptide N-tetradecanoyltransferase 2 (EC:2.3.1.97)
Alternative name(s):
Myristoyl-CoA:protein N-myristoyltransferase 2
Short name:
NMT 2
Peptide N-myristoyltransferase 2
Type II N-myristoyltransferase
Gene namesi
Name:NMT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:7858. NMT2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. cytosol Source: Reactome
  3. Golgi apparatus Source: HPA
  4. plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31662.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 498498Glycylpeptide N-tetradecanoyltransferase 2PRO_0000064226Add
BLAST

Proteomic databases

MaxQBiO60551.
PaxDbiO60551.
PRIDEiO60551.

PTM databases

PhosphoSiteiO60551.

Expressioni

Gene expression databases

ArrayExpressiO60551.
BgeeiO60551.
CleanExiHS_NMT2.
GenevestigatoriO60551.

Organism-specific databases

HPAiHPA001303.

Interactioni

Protein-protein interaction databases

BioGridi114794. 10 interactions.
IntActiO60551. 10 interactions.
MINTiMINT-1795376.
STRINGi9606.ENSP00000367407.

Structurei

3D structure databases

ProteinModelPortaliO60551.
SMRiO60551. Positions 119-498.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi46 – 5611Poly-LysAdd
BLAST

Sequence similaritiesi

Belongs to the NMT family.

Phylogenomic databases

eggNOGiCOG5092.
HOGENOMiHOG000189123.
HOVERGENiHBG003404.
KOiK00671.
OMAiQRTIKLY.
OrthoDBiEOG76DTS3.
PhylomeDBiO60551.
TreeFamiTF300701.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view]
PANTHERiPTHR11377. PTHR11377. 1 hit.
PfamiPF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view]
PIRSFiPIRSF015892. N-myristl_transf. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
PROSITEiPS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60551-1 [UniParc]FASTAAdd to Basket

« Hide

MAEDSESAAS QQSLELDDQD TCGIDGDNEE ETEHAKGSPG GYLGAKKKKK    50
KQKRKKEKPN SGGTKSDSAS DSQEIKIQQP SKNPSVPMQK LQDIQRAMEL 100
LSACQGPARN IDEAAKHRYQ FWDTQPVPKL DEVITSHGAI EPDKDNVRQE 150
PYSLPQGFMW DTLDLSDAEV LKELYTLLNE NYVEDDDNMF RFDYSPEFLL 200
WALRPPGWLL QWHCGVRVSS NKKLVGFISA IPANIRIYDS VKKMVEINFL 250
CVHKKLRSKR VAPVLIREIT RRVNLEGIFQ AVYTAGVVLP KPIATCRYWH 300
RSLNPRKLVE VKFSHLSRNM TLQRTMKLYR LPDVTKTSGL RPMEPKDIKS 350
VRELINTYLK QFHLAPVMDE EEVAHWFLPR EHIIDTFVVE SPNGKLTDFL 400
SFYTLPSTVM HHPAHKSLKA AYSFYNIHTE TPLLDLMSDA LILAKSKGFD 450
VFNALDLMEN KTFLEKLKFG IGDGNLQYYL YNWRCPGTDS EKVGLVLQ 498
Length:498
Mass (Da):56,980
Last modified:August 1, 1998 - v1
Checksum:i1B1486CC6559B6A9
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti306 – 3061R → K in AAP35670. 1 Publication
Sequence conflicti306 – 3061R → K in AAH06376. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF043325 mRNA. Translation: AAC09295.1.
AF232826 mRNA. Translation: AAF36406.2.
BT007024 mRNA. Translation: AAP35670.1.
EF445001 Genomic DNA. Translation: ACA06028.1.
EF445001 Genomic DNA. Translation: ACA06029.1.
AL590365 Genomic DNA. Translation: CAH73971.1.
CH471072 Genomic DNA. Translation: EAW86238.1.
BC006376 mRNA. Translation: AAH06376.1.
CCDSiCCDS7109.1.
RefSeqiNP_004799.1. NM_004808.2.
UniGeneiHs.60339.

Genome annotation databases

EnsembliENST00000378165; ENSP00000367407; ENSG00000152465.
GeneIDi9397.
KEGGihsa:9397.
UCSCiuc001inz.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF043325 mRNA. Translation: AAC09295.1 .
AF232826 mRNA. Translation: AAF36406.2 .
BT007024 mRNA. Translation: AAP35670.1 .
EF445001 Genomic DNA. Translation: ACA06028.1 .
EF445001 Genomic DNA. Translation: ACA06029.1 .
AL590365 Genomic DNA. Translation: CAH73971.1 .
CH471072 Genomic DNA. Translation: EAW86238.1 .
BC006376 mRNA. Translation: AAH06376.1 .
CCDSi CCDS7109.1.
RefSeqi NP_004799.1. NM_004808.2.
UniGenei Hs.60339.

3D structure databases

ProteinModelPortali O60551.
SMRi O60551. Positions 119-498.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114794. 10 interactions.
IntActi O60551. 10 interactions.
MINTi MINT-1795376.
STRINGi 9606.ENSP00000367407.

Chemistry

BindingDBi O60551.
ChEMBLi CHEMBL2096973.

PTM databases

PhosphoSitei O60551.

Proteomic databases

MaxQBi O60551.
PaxDbi O60551.
PRIDEi O60551.

Protocols and materials databases

DNASUi 9397.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000378165 ; ENSP00000367407 ; ENSG00000152465 .
GeneIDi 9397.
KEGGi hsa:9397.
UCSCi uc001inz.1. human.

Organism-specific databases

CTDi 9397.
GeneCardsi GC10M015144.
HGNCi HGNC:7858. NMT2.
HPAi HPA001303.
MIMi 603801. gene.
neXtProti NX_O60551.
PharmGKBi PA31662.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5092.
HOGENOMi HOG000189123.
HOVERGENi HBG003404.
KOi K00671.
OMAi QRTIKLY.
OrthoDBi EOG76DTS3.
PhylomeDBi O60551.
TreeFami TF300701.

Enzyme and pathway databases

BRENDAi 2.3.1.97. 2681.
Reactomei REACT_115893. Membrane binding and targetting of GAG proteins.
REACT_163919. Inactivation, recovery and regulation of the phototransduction cascade.

Miscellaneous databases

ChiTaRSi NMT2. human.
GeneWikii NMT2.
GenomeRNAii 9397.
NextBioi 35199.
PROi O60551.
SOURCEi Search...

Gene expression databases

ArrayExpressi O60551.
Bgeei O60551.
CleanExi HS_NMT2.
Genevestigatori O60551.

Family and domain databases

Gene3Di 3.40.630.30. 2 hits.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view ]
PANTHERi PTHR11377. PTHR11377. 1 hit.
Pfami PF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF015892. N-myristl_transf. 1 hit.
SUPFAMi SSF55729. SSF55729. 2 hits.
PROSITEi PS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A second mammalian N-myristoyltransferase."
    Giang D.K., Cravatt B.F.
    J. Biol. Chem. 273:6595-6598(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. Rundle D.R., Anderson R.E.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. NHLBI resequencing and genotyping service (RS&G)
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNMT2_HUMAN
AccessioniPrimary (citable) accession number: O60551
Secondary accession number(s): B0YJ49
, Q53Y38, Q5VUC8, Q9BRB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: September 3, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Sequence AAF36406.2 was incorrectly indicated as originating from bovine.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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