Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O60551

- NMT2_HUMAN

UniProt

O60551 - NMT2_HUMAN

Protein

Glycylpeptide N-tetradecanoyltransferase 2

Gene

NMT2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

    Catalytic activityi

    Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.

    GO - Molecular functioni

    1. catalytic activity Source: ProtInc
    2. glycylpeptide N-tetradecanoyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. intracellular transport of virus Source: Reactome
    2. N-terminal protein myristoylation Source: InterPro
    3. phototransduction, visible light Source: Reactome
    4. protein lipoylation Source: ProtInc
    5. regulation of rhodopsin mediated signaling pathway Source: Reactome
    6. rhodopsin mediated signaling pathway Source: Reactome
    7. viral process Source: Reactome
    8. viral protein processing Source: Reactome
    9. virion assembly Source: Reactome

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.3.1.97. 2681.
    ReactomeiREACT_115893. Membrane binding and targetting of GAG proteins.
    REACT_163919. Inactivation, recovery and regulation of the phototransduction cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycylpeptide N-tetradecanoyltransferase 2 (EC:2.3.1.97)
    Alternative name(s):
    Myristoyl-CoA:protein N-myristoyltransferase 2
    Short name:
    NMT 2
    Peptide N-myristoyltransferase 2
    Type II N-myristoyltransferase
    Gene namesi
    Name:NMT2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:7858. NMT2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: Reactome
    3. Golgi apparatus Source: HPA
    4. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31662.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 498498Glycylpeptide N-tetradecanoyltransferase 2PRO_0000064226Add
    BLAST

    Proteomic databases

    MaxQBiO60551.
    PaxDbiO60551.
    PRIDEiO60551.

    PTM databases

    PhosphoSiteiO60551.

    Expressioni

    Gene expression databases

    ArrayExpressiO60551.
    BgeeiO60551.
    CleanExiHS_NMT2.
    GenevestigatoriO60551.

    Organism-specific databases

    HPAiHPA001303.

    Interactioni

    Protein-protein interaction databases

    BioGridi114794. 10 interactions.
    IntActiO60551. 10 interactions.
    MINTiMINT-1795376.
    STRINGi9606.ENSP00000367407.

    Structurei

    3D structure databases

    ProteinModelPortaliO60551.
    SMRiO60551. Positions 119-498.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi46 – 5611Poly-LysAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NMT family.Curated

    Phylogenomic databases

    eggNOGiCOG5092.
    HOGENOMiHOG000189123.
    HOVERGENiHBG003404.
    KOiK00671.
    OMAiQRTIKLY.
    OrthoDBiEOG76DTS3.
    PhylomeDBiO60551.
    TreeFamiTF300701.

    Family and domain databases

    Gene3Di3.40.630.30. 2 hits.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR000903. MyristoylCoA_TrFase.
    IPR022677. MyristoylCoA_TrFase_C.
    IPR022678. MyristoylCoA_TrFase_CS.
    IPR022676. MyristoylCoA_TrFase_N.
    [Graphical view]
    PANTHERiPTHR11377. PTHR11377. 1 hit.
    PfamiPF01233. NMT. 1 hit.
    PF02799. NMT_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015892. N-myristl_transf. 1 hit.
    SUPFAMiSSF55729. SSF55729. 2 hits.
    PROSITEiPS00975. NMT_1. 1 hit.
    PS00976. NMT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O60551-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEDSESAAS QQSLELDDQD TCGIDGDNEE ETEHAKGSPG GYLGAKKKKK    50
    KQKRKKEKPN SGGTKSDSAS DSQEIKIQQP SKNPSVPMQK LQDIQRAMEL 100
    LSACQGPARN IDEAAKHRYQ FWDTQPVPKL DEVITSHGAI EPDKDNVRQE 150
    PYSLPQGFMW DTLDLSDAEV LKELYTLLNE NYVEDDDNMF RFDYSPEFLL 200
    WALRPPGWLL QWHCGVRVSS NKKLVGFISA IPANIRIYDS VKKMVEINFL 250
    CVHKKLRSKR VAPVLIREIT RRVNLEGIFQ AVYTAGVVLP KPIATCRYWH 300
    RSLNPRKLVE VKFSHLSRNM TLQRTMKLYR LPDVTKTSGL RPMEPKDIKS 350
    VRELINTYLK QFHLAPVMDE EEVAHWFLPR EHIIDTFVVE SPNGKLTDFL 400
    SFYTLPSTVM HHPAHKSLKA AYSFYNIHTE TPLLDLMSDA LILAKSKGFD 450
    VFNALDLMEN KTFLEKLKFG IGDGNLQYYL YNWRCPGTDS EKVGLVLQ 498
    Length:498
    Mass (Da):56,980
    Last modified:August 1, 1998 - v1
    Checksum:i1B1486CC6559B6A9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti306 – 3061R → K in AAP35670. 1 PublicationCurated
    Sequence conflicti306 – 3061R → K in AAH06376. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF043325 mRNA. Translation: AAC09295.1.
    AF232826 mRNA. Translation: AAF36406.2.
    BT007024 mRNA. Translation: AAP35670.1.
    EF445001 Genomic DNA. Translation: ACA06028.1.
    EF445001 Genomic DNA. Translation: ACA06029.1.
    AL590365 Genomic DNA. Translation: CAH73971.1.
    CH471072 Genomic DNA. Translation: EAW86238.1.
    BC006376 mRNA. Translation: AAH06376.1.
    CCDSiCCDS7109.1.
    RefSeqiNP_004799.1. NM_004808.2.
    UniGeneiHs.60339.

    Genome annotation databases

    EnsembliENST00000378165; ENSP00000367407; ENSG00000152465.
    GeneIDi9397.
    KEGGihsa:9397.
    UCSCiuc001inz.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF043325 mRNA. Translation: AAC09295.1 .
    AF232826 mRNA. Translation: AAF36406.2 .
    BT007024 mRNA. Translation: AAP35670.1 .
    EF445001 Genomic DNA. Translation: ACA06028.1 .
    EF445001 Genomic DNA. Translation: ACA06029.1 .
    AL590365 Genomic DNA. Translation: CAH73971.1 .
    CH471072 Genomic DNA. Translation: EAW86238.1 .
    BC006376 mRNA. Translation: AAH06376.1 .
    CCDSi CCDS7109.1.
    RefSeqi NP_004799.1. NM_004808.2.
    UniGenei Hs.60339.

    3D structure databases

    ProteinModelPortali O60551.
    SMRi O60551. Positions 119-498.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114794. 10 interactions.
    IntActi O60551. 10 interactions.
    MINTi MINT-1795376.
    STRINGi 9606.ENSP00000367407.

    Chemistry

    BindingDBi O60551.
    ChEMBLi CHEMBL2096973.

    PTM databases

    PhosphoSitei O60551.

    Proteomic databases

    MaxQBi O60551.
    PaxDbi O60551.
    PRIDEi O60551.

    Protocols and materials databases

    DNASUi 9397.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000378165 ; ENSP00000367407 ; ENSG00000152465 .
    GeneIDi 9397.
    KEGGi hsa:9397.
    UCSCi uc001inz.1. human.

    Organism-specific databases

    CTDi 9397.
    GeneCardsi GC10M015144.
    HGNCi HGNC:7858. NMT2.
    HPAi HPA001303.
    MIMi 603801. gene.
    neXtProti NX_O60551.
    PharmGKBi PA31662.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5092.
    HOGENOMi HOG000189123.
    HOVERGENi HBG003404.
    KOi K00671.
    OMAi QRTIKLY.
    OrthoDBi EOG76DTS3.
    PhylomeDBi O60551.
    TreeFami TF300701.

    Enzyme and pathway databases

    BRENDAi 2.3.1.97. 2681.
    Reactomei REACT_115893. Membrane binding and targetting of GAG proteins.
    REACT_163919. Inactivation, recovery and regulation of the phototransduction cascade.

    Miscellaneous databases

    ChiTaRSi NMT2. human.
    GeneWikii NMT2.
    GenomeRNAii 9397.
    NextBioi 35199.
    PROi O60551.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60551.
    Bgeei O60551.
    CleanExi HS_NMT2.
    Genevestigatori O60551.

    Family and domain databases

    Gene3Di 3.40.630.30. 2 hits.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR000903. MyristoylCoA_TrFase.
    IPR022677. MyristoylCoA_TrFase_C.
    IPR022678. MyristoylCoA_TrFase_CS.
    IPR022676. MyristoylCoA_TrFase_N.
    [Graphical view ]
    PANTHERi PTHR11377. PTHR11377. 1 hit.
    Pfami PF01233. NMT. 1 hit.
    PF02799. NMT_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015892. N-myristl_transf. 1 hit.
    SUPFAMi SSF55729. SSF55729. 2 hits.
    PROSITEi PS00975. NMT_1. 1 hit.
    PS00976. NMT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A second mammalian N-myristoyltransferase."
      Giang D.K., Cravatt B.F.
      J. Biol. Chem. 273:6595-6598(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. Rundle D.R., Anderson R.E.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. NHLBI resequencing and genotyping service (RS&G)
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiNMT2_HUMAN
    AccessioniPrimary (citable) accession number: O60551
    Secondary accession number(s): B0YJ49
    , Q53Y38, Q5VUC8, Q9BRB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Sequence AAF36406.2 was incorrectly indicated as originating from bovine.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3