Reviewed,
UniProtKB/Swiss-Prot O60551 (NMT2_HUMAN)
Last modified
October 13, 2009.
Version 78.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Glycylpeptide N-tetradecanoyltransferase 2 EC=2.3.1.97 Alternative name(s): Peptide N-myristoyltransferase 2 Myristoyl-CoA:protein N-myristoyltransferase 2 Short name=NMT 2 Type II N-myristoyltransferase | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 498 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. |
| Catalytic activity | Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide. |
| Subcellular location | |
| Sequence similarities | Belongs to the NMT family. |
| Caution | Ref.2 sequence is incorrectly indicated as originating from bovine. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Molecular function | Acyltransferase Transferase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | N-terminal protein myristoylation Inferred from electronic annotation. Source: InterPro protein lipoylation Ref.1Traceable author statement. Source: ProtInc |
| Cellular component | Golgi apparatus Inferred from direct assay. Source: HPA |
| Molecular function | glycylpeptide N-tetradecanoyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 498 | 498 | Glycylpeptide N-tetradecanoyltransferase 2 | PRO_0000064226 | |||||
Regions | |||||||||
| Compositional bias | 46 – 56 | 11 | Poly-Lys | ||||||
Amino acid modifications | |||||||||
| Modified residue | 66 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 68 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 70 | 1 | Phosphoserine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 306 | 1 | R → K in AAP35670. Ref.3 | ||||||
| Sequence conflict | 306 | 1 | R → K in AAH06376. Ref.5 | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "A second mammalian N-myristoyltransferase." Giang D.K., Cravatt B.F. J. Biol. Chem. 273:6595-6598(1998) [PubMed: 9506952] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver. |
| [2] | Rundle D.R., Anderson R.E. Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver. |
| [3] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. Rogers J.Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin. |
| [6] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF043325 mRNA. Translation: AAC09295.1. AF232826 mRNA. Translation: AAF36406.2. BT007024 mRNA. Translation: AAP35670.1. AL590365 Genomic DNA. Translation: CAH73971.1. BC006376 mRNA. Translation: AAH06376.1. | |
| IPI | IPI00030223. |
| RefSeq | NP_004799.1. |
| UniGene | Hs.60339 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1IYL based on UniProtKB P30418. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | O60551. |
PTM databases | |
| PhosphoSite | O60551. |
Proteomic databases | |
| PRIDE | O60551. |
Genome annotation databases | |
| Ensembl | ENST00000378143; ENSP00000367385; ENSG00000152465; Homo sapiens. [Genome view] ENST00000378150; ENSP00000367392; ENSG00000152465; Homo sapiens. [Genome view] ENST00000378165; ENSP00000367407; ENSG00000152465; Homo sapiens. [Genome view] ENST00000396794; ENSP00000380012; ENSG00000152465; Homo sapiens. [Genome view] ENST00000396800; ENSP00000380018; ENSG00000152465; Homo sapiens. [Genome view] ENST00000441445; ENSP00000408127; ENSG00000152465; Homo sapiens. [Genome view] |
| GeneID | 9397. |
| KEGG | hsa:9397. |
| UCSC | uc001inz.1. human. |
Organism-specific databases | |
| CTD | 9397. |
| GeneCards | GC10M015172. |
| H-InvDB | HIX0008674. |
| HGNC | HGNC:7858. NMT2. |
| HPA | HPA001303. |
| MIM | 603801. gene. |
| PharmGKB | PA27444. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | O60551. |
Enzyme and pathway databases | |
| BRENDA | 2.3.1.97. 247. |
Gene expression databases | |
| ArrayExpress | O60551. |
| Bgee | O60551. |
| CleanEx | HS_NMT2. |
| Genevestigator | O60551. |
| GermOnline | ENSG00000152465. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR016181. Acyl_CoA_acyltransferase. IPR000903. Myristoyl_trans. [Graphical view] |
| Gene3D | G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 2 hits. |
| PANTHER | PTHR11377. Myristoyl_trans. 1 hit. |
| Pfam | PF01233. NMT. 1 hit. PF02799. NMT_C. 1 hit. [Graphical view] |
| PIRSF | PIRSF015892. N-myristl_transf. 1 hit. |
| PROSITE | PS00975. NMT_1. 1 hit. PS00976. NMT_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 35199. |
| SOURCE | Search... |
Entry information
| Entry name | NMT2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O60551 Secondary accession number(s): Q53Y38, Q5VUC8, Q9BRB4 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 10 Human chromosome 10: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


