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Protein

Glycylpeptide N-tetradecanoyltransferase 2

Gene

NMT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.2 Publications

Catalytic activityi

Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.2 Publications

GO - Molecular functioni

  • glycylpeptide N-tetradecanoyltransferase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciZFISH:HS07823-MONOMER.
BRENDAi2.3.1.97. 2681.
ReactomeiR-HSA-174490. Membrane binding and targetting of GAG proteins.
R-HSA-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycylpeptide N-tetradecanoyltransferase 2 (EC:2.3.1.972 Publications)
Alternative name(s):
Myristoyl-CoA:protein N-myristoyltransferase 2
Short name:
NMT 2
Peptide N-myristoyltransferase 2
Type II N-myristoyltransferase
Gene namesi
Name:NMT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:7858. NMT2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
  • extrinsic component of membrane Source: UniProtKB
  • Golgi apparatus Source: HPA
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9397.
OpenTargetsiENSG00000152465.
PharmGKBiPA31662.

Chemistry databases

ChEMBLiCHEMBL2849.

Polymorphism and mutation databases

BioMutaiNMT2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642261 – 498Glycylpeptide N-tetradecanoyltransferase 2Add BLAST498

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO60551.
MaxQBiO60551.
PaxDbiO60551.
PeptideAtlasiO60551.
PRIDEiO60551.

PTM databases

iPTMnetiO60551.
PhosphoSitePlusiO60551.
SwissPalmiO60551.

Expressioni

Gene expression databases

BgeeiENSG00000152465.
CleanExiHS_NMT2.
ExpressionAtlasiO60551. baseline and differential.
GenevisibleiO60551. HS.

Organism-specific databases

HPAiHPA001303.

Interactioni

Protein-protein interaction databases

BioGridi114794. 31 interactors.
IntActiO60551. 11 interactors.
MINTiMINT-1795376.
STRINGi9606.ENSP00000367407.

Chemistry databases

BindingDBiO60551.

Structurei

Secondary structure

1498
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi122 – 124Combined sources3
Beta strandi125 – 127Combined sources3
Beta strandi158 – 162Combined sources5
Helixi168 – 181Combined sources14
Beta strandi186 – 192Combined sources7
Helixi196 – 203Combined sources8
Helixi210 – 212Combined sources3
Beta strandi213 – 218Combined sources6
Turni219 – 221Combined sources3
Beta strandi224 – 237Combined sources14
Beta strandi240 – 252Combined sources13
Helixi254 – 256Combined sources3
Helixi262 – 274Combined sources13
Turni275 – 277Combined sources3
Beta strandi281 – 287Combined sources7
Beta strandi293 – 303Combined sources11
Helixi305 – 310Combined sources6
Helixi322 – 328Combined sources7
Beta strandi340 – 342Combined sources3
Helixi345 – 347Combined sources3
Helixi348 – 358Combined sources11
Helixi359 – 361Combined sources3
Beta strandi362 – 366Combined sources5
Helixi370 – 377Combined sources8
Turni381 – 383Combined sources3
Beta strandi384 – 390Combined sources7
Beta strandi392 – 394Combined sources3
Beta strandi396 – 404Combined sources9
Beta strandi407 – 409Combined sources3
Beta strandi416 – 418Combined sources3
Beta strandi420 – 423Combined sources4
Beta strandi427 – 431Combined sources5
Helixi433 – 445Combined sources13
Turni446 – 448Combined sources3
Beta strandi450 – 456Combined sources7
Helixi460 – 462Combined sources3
Turni463 – 468Combined sources6
Beta strandi470 – 482Combined sources13
Helixi490 – 492Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4C2XX-ray2.33A112-498[»]
ProteinModelPortaliO60551.
SMRiO60551.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni120 – 122Myristoyl-CoA binding1 Publication3
Regioni250 – 252Myristoyl-CoA binding1 Publication3
Regioni258 – 262Myristoyl-CoA binding1 Publication5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi46 – 56Poly-LysAdd BLAST11

Sequence similaritiesi

Belongs to the NMT family.Curated

Phylogenomic databases

eggNOGiKOG2779. Eukaryota.
COG5092. LUCA.
GeneTreeiENSGT00390000017837.
HOGENOMiHOG000189123.
HOVERGENiHBG003404.
InParanoidiO60551.
KOiK00671.
OMAiEGIIDCF.
OrthoDBiEOG091G06JB.
PhylomeDBiO60551.
TreeFamiTF300701.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view]
PANTHERiPTHR11377. PTHR11377. 1 hit.
PfamiPF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view]
PIRSFiPIRSF015892. N-myristl_transf. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
PROSITEiPS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60551-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEDSESAAS QQSLELDDQD TCGIDGDNEE ETEHAKGSPG GYLGAKKKKK
60 70 80 90 100
KQKRKKEKPN SGGTKSDSAS DSQEIKIQQP SKNPSVPMQK LQDIQRAMEL
110 120 130 140 150
LSACQGPARN IDEAAKHRYQ FWDTQPVPKL DEVITSHGAI EPDKDNVRQE
160 170 180 190 200
PYSLPQGFMW DTLDLSDAEV LKELYTLLNE NYVEDDDNMF RFDYSPEFLL
210 220 230 240 250
WALRPPGWLL QWHCGVRVSS NKKLVGFISA IPANIRIYDS VKKMVEINFL
260 270 280 290 300
CVHKKLRSKR VAPVLIREIT RRVNLEGIFQ AVYTAGVVLP KPIATCRYWH
310 320 330 340 350
RSLNPRKLVE VKFSHLSRNM TLQRTMKLYR LPDVTKTSGL RPMEPKDIKS
360 370 380 390 400
VRELINTYLK QFHLAPVMDE EEVAHWFLPR EHIIDTFVVE SPNGKLTDFL
410 420 430 440 450
SFYTLPSTVM HHPAHKSLKA AYSFYNIHTE TPLLDLMSDA LILAKSKGFD
460 470 480 490
VFNALDLMEN KTFLEKLKFG IGDGNLQYYL YNWRCPGTDS EKVGLVLQ
Length:498
Mass (Da):56,980
Last modified:August 1, 1998 - v1
Checksum:i1B1486CC6559B6A9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti306R → K in AAP35670 (Ref. 3) Curated1
Sequence conflicti306R → K in AAH06376 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043325 mRNA. Translation: AAC09295.1.
AF232826 mRNA. Translation: AAF36406.2.
BT007024 mRNA. Translation: AAP35670.1.
EF445001 Genomic DNA. Translation: ACA06028.1.
EF445001 Genomic DNA. Translation: ACA06029.1.
AL590365 Genomic DNA. Translation: CAH73971.1.
CH471072 Genomic DNA. Translation: EAW86238.1.
BC006376 mRNA. Translation: AAH06376.1.
CCDSiCCDS7109.1.
RefSeqiNP_001295224.1. NM_001308295.1.
NP_004799.1. NM_004808.2.
UniGeneiHs.60339.

Genome annotation databases

EnsembliENST00000378165; ENSP00000367407; ENSG00000152465.
GeneIDi9397.
KEGGihsa:9397.
UCSCiuc001inz.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043325 mRNA. Translation: AAC09295.1.
AF232826 mRNA. Translation: AAF36406.2.
BT007024 mRNA. Translation: AAP35670.1.
EF445001 Genomic DNA. Translation: ACA06028.1.
EF445001 Genomic DNA. Translation: ACA06029.1.
AL590365 Genomic DNA. Translation: CAH73971.1.
CH471072 Genomic DNA. Translation: EAW86238.1.
BC006376 mRNA. Translation: AAH06376.1.
CCDSiCCDS7109.1.
RefSeqiNP_001295224.1. NM_001308295.1.
NP_004799.1. NM_004808.2.
UniGeneiHs.60339.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4C2XX-ray2.33A112-498[»]
ProteinModelPortaliO60551.
SMRiO60551.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114794. 31 interactors.
IntActiO60551. 11 interactors.
MINTiMINT-1795376.
STRINGi9606.ENSP00000367407.

Chemistry databases

BindingDBiO60551.
ChEMBLiCHEMBL2849.

PTM databases

iPTMnetiO60551.
PhosphoSitePlusiO60551.
SwissPalmiO60551.

Polymorphism and mutation databases

BioMutaiNMT2.

Proteomic databases

EPDiO60551.
MaxQBiO60551.
PaxDbiO60551.
PeptideAtlasiO60551.
PRIDEiO60551.

Protocols and materials databases

DNASUi9397.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378165; ENSP00000367407; ENSG00000152465.
GeneIDi9397.
KEGGihsa:9397.
UCSCiuc001inz.2. human.

Organism-specific databases

CTDi9397.
DisGeNETi9397.
GeneCardsiNMT2.
HGNCiHGNC:7858. NMT2.
HPAiHPA001303.
MIMi603801. gene.
neXtProtiNX_O60551.
OpenTargetsiENSG00000152465.
PharmGKBiPA31662.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2779. Eukaryota.
COG5092. LUCA.
GeneTreeiENSGT00390000017837.
HOGENOMiHOG000189123.
HOVERGENiHBG003404.
InParanoidiO60551.
KOiK00671.
OMAiEGIIDCF.
OrthoDBiEOG091G06JB.
PhylomeDBiO60551.
TreeFamiTF300701.

Enzyme and pathway databases

BioCyciZFISH:HS07823-MONOMER.
BRENDAi2.3.1.97. 2681.
ReactomeiR-HSA-174490. Membrane binding and targetting of GAG proteins.
R-HSA-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Miscellaneous databases

ChiTaRSiNMT2. human.
GeneWikiiNMT2.
GenomeRNAii9397.
PROiO60551.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000152465.
CleanExiHS_NMT2.
ExpressionAtlasiO60551. baseline and differential.
GenevisibleiO60551. HS.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view]
PANTHERiPTHR11377. PTHR11377. 1 hit.
PfamiPF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view]
PIRSFiPIRSF015892. N-myristl_transf. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
PROSITEiPS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNMT2_HUMAN
AccessioniPrimary (citable) accession number: O60551
Secondary accession number(s): B0YJ49
, Q53Y38, Q5VUC8, Q9BRB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Sequence AAF36406.2 was incorrectly indicated as originating from bovine.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.