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O60551 (NMT2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycylpeptide N-tetradecanoyltransferase 2

EC=2.3.1.97
Alternative name(s):
Myristoyl-CoA:protein N-myristoyltransferase 2
Short name=NMT 2
Peptide N-myristoyltransferase 2
Type II N-myristoyltransferase
Gene names
Name:NMT2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Catalytic activity

Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the NMT family.

Caution

Sequence AAF36406.2 was incorrectly indicated as originating from bovine.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 498498Glycylpeptide N-tetradecanoyltransferase 2
PRO_0000064226

Regions

Compositional bias46 – 5611Poly-Lys

Experimental info

Sequence conflict3061R → K in AAP35670. Ref.3
Sequence conflict3061R → K in AAH06376. Ref.7

Sequences

Sequence LengthMass (Da)Tools
O60551 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 1B1486CC6559B6A9

FASTA49856,980
        10         20         30         40         50         60 
MAEDSESAAS QQSLELDDQD TCGIDGDNEE ETEHAKGSPG GYLGAKKKKK KQKRKKEKPN 

        70         80         90        100        110        120 
SGGTKSDSAS DSQEIKIQQP SKNPSVPMQK LQDIQRAMEL LSACQGPARN IDEAAKHRYQ 

       130        140        150        160        170        180 
FWDTQPVPKL DEVITSHGAI EPDKDNVRQE PYSLPQGFMW DTLDLSDAEV LKELYTLLNE 

       190        200        210        220        230        240 
NYVEDDDNMF RFDYSPEFLL WALRPPGWLL QWHCGVRVSS NKKLVGFISA IPANIRIYDS 

       250        260        270        280        290        300 
VKKMVEINFL CVHKKLRSKR VAPVLIREIT RRVNLEGIFQ AVYTAGVVLP KPIATCRYWH 

       310        320        330        340        350        360 
RSLNPRKLVE VKFSHLSRNM TLQRTMKLYR LPDVTKTSGL RPMEPKDIKS VRELINTYLK 

       370        380        390        400        410        420 
QFHLAPVMDE EEVAHWFLPR EHIIDTFVVE SPNGKLTDFL SFYTLPSTVM HHPAHKSLKA 

       430        440        450        460        470        480 
AYSFYNIHTE TPLLDLMSDA LILAKSKGFD VFNALDLMEN KTFLEKLKFG IGDGNLQYYL 

       490 
YNWRCPGTDS EKVGLVLQ 

« Hide

References

« Hide 'large scale' references
[1]"A second mammalian N-myristoyltransferase."
Giang D.K., Cravatt B.F.
J. Biol. Chem. 273:6595-6598(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]Rundle D.R., Anderson R.E.
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]NHLBI resequencing and genotyping service (RS&G)
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF043325 mRNA. Translation: AAC09295.1.
AF232826 mRNA. Translation: AAF36406.2.
BT007024 mRNA. Translation: AAP35670.1.
EF445001 Genomic DNA. Translation: ACA06028.1.
EF445001 Genomic DNA. Translation: ACA06029.1.
AL590365 Genomic DNA. Translation: CAH73971.1.
CH471072 Genomic DNA. Translation: EAW86238.1.
BC006376 mRNA. Translation: AAH06376.1.
RefSeqNP_004799.1. NM_004808.2.
UniGeneHs.60339.

3D structure databases

ProteinModelPortalO60551.
SMRO60551. Positions 89-498.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114794. 10 interactions.
IntActO60551. 10 interactions.
MINTMINT-1795376.
STRING9606.ENSP00000367407.

Chemistry

BindingDBO60551.
ChEMBLCHEMBL2096973.

PTM databases

PhosphoSiteO60551.

Proteomic databases

PaxDbO60551.
PRIDEO60551.

Protocols and materials databases

DNASU9397.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000378165; ENSP00000367407; ENSG00000152465.
GeneID9397.
KEGGhsa:9397.
UCSCuc001inz.1. human.

Organism-specific databases

CTD9397.
GeneCardsGC10M015144.
HGNCHGNC:7858. NMT2.
HPAHPA001303.
MIM603801. gene.
neXtProtNX_O60551.
PharmGKBPA31662.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5092.
HOGENOMHOG000189123.
HOVERGENHBG003404.
KOK00671.
OrthoDBEOG76DTS3.
PhylomeDBO60551.
TreeFamTF300701.

Enzyme and pathway databases

BRENDA2.3.1.97. 2681.
ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.

Gene expression databases

ArrayExpressO60551.
BgeeO60551.
CleanExHS_NMT2.
GenevestigatorO60551.

Family and domain databases

Gene3D3.40.630.30. 2 hits.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view]
PANTHERPTHR11377. PTHR11377. 1 hit.
PfamPF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view]
PIRSFPIRSF015892. N-myristl_transf. 1 hit.
SUPFAMSSF55729. SSF55729. 2 hits.
PROSITEPS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNMT2. human.
GeneWikiNMT2.
GenomeRNAi9397.
NextBio35199.
PROO60551.
SOURCESearch...

Entry information

Entry nameNMT2_HUMAN
AccessionPrimary (citable) accession number: O60551
Secondary accession number(s): B0YJ49 expand/collapse secondary AC list , Q53Y38, Q5VUC8, Q9BRB4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: April 16, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM