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Reviewed, UniProtKB/Swiss-Prot O60551 (NMT2_HUMAN)

Last modified November 25, 2008. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Glycylpeptide N-tetradecanoyltransferase 2
    EC=2.3.1.97
Alternative name(s):
    Peptide N-myristoyltransferase 2
    Myristoyl-CoA:protein N-myristoyltransferase 2
      Short name=NMT 2
    Type II N-myristoyltransferase
Gene names
Name: NMT2
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Catalytic activity

Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the NMT family.

Caution

Ref.2 sequence is incorrectly indicated as originating from bovine.

Ontologies

Keywords

   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase

Gene Ontology (GO)

   Biological processN-terminal protein myristoylation

Inferred from electronic annotation. Source: InterPro

protein lipoylation Ref.1

Traceable author statement. Source: ProtInc

   Cellular componentGolgi apparatus

Inferred from direct assay. Source: HPA

   Molecular functionglycylpeptide N-tetradecanoyltransferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 498498Glycylpeptide N-tetradecanoyltransferase 2
PRO_0000064226

Regions

Compositional bias46 – 5611Poly-Lys

Experimental info

Sequence conflict3061R → K in AAP35670. Ref.3
Sequence conflict3061R → K in AAH06376. Ref.5

Sequences

Sequence LengthMass (Da)Tools
O60551-1 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 1B1486CC6559B6A9

FASTA49856,980
        10         20         30         40         50         60 
MAEDSESAAS QQSLELDDQD TCGIDGDNEE ETEHAKGSPG GYLGAKKKKK KQKRKKEKPN 

        70         80         90        100        110        120 
SGGTKSDSAS DSQEIKIQQP SKNPSVPMQK LQDIQRAMEL LSACQGPARN IDEAAKHRYQ 

       130        140        150        160        170        180 
FWDTQPVPKL DEVITSHGAI EPDKDNVRQE PYSLPQGFMW DTLDLSDAEV LKELYTLLNE 

       190        200        210        220        230        240 
NYVEDDDNMF RFDYSPEFLL WALRPPGWLL QWHCGVRVSS NKKLVGFISA IPANIRIYDS 

       250        260        270        280        290        300 
VKKMVEINFL CVHKKLRSKR VAPVLIREIT RRVNLEGIFQ AVYTAGVVLP KPIATCRYWH 

       310        320        330        340        350        360 
RSLNPRKLVE VKFSHLSRNM TLQRTMKLYR LPDVTKTSGL RPMEPKDIKS VRELINTYLK 

       370        380        390        400        410        420 
QFHLAPVMDE EEVAHWFLPR EHIIDTFVVE SPNGKLTDFL SFYTLPSTVM HHPAHKSLKA 

       430        440        450        460        470        480 
AYSFYNIHTE TPLLDLMSDA LILAKSKGFD VFNALDLMEN KTFLEKLKFG IGDGNLQYYL 

       490 
YNWRCPGTDS EKVGLVLQ 

« Hide

References

« Hide 'large scale' references
[1]"A second mammalian N-myristoyltransferase."
Giang D.K., Cravatt B.F.
J. Biol. Chem. 273:6595-6598(1998) [PubMed: 9506952] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]Rundle D.R., Anderson R.E.
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed: 15164054] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
+Additional computationally mapped references.

Cross-references

Sequence databases

AF043325 mRNA. Translation: AAC09295.1.
AF232826 mRNA. Translation: AAF36406.2.
BT007024 mRNA. Translation: AAP35670.1.
AL590365 Genomic DNA. Translation: CAH73971.1.
BC006376 mRNA. Translation: AAH06376.1.
RefSeqNP_004799.1.
UniGeneHs.60339

3D structure databases

HSSPHSSP built from PDB template 1IYL based on UniProtKB P30418.
ModBaseSearch...

PTM databases

PhosphoSiteO60551.

Genome annotation databases

EnsemblENSG00000152465. Homo sapiens. [Contig view]
GeneID9397.
KEGGhsa:9397.

Organism-specific databases

H-InvDBHIX0008674.
HGNCHGNC:7858. NMT2.
HPAHPA001303.
MIM603801. gene.
PharmGKBPA27444.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOVERGENO60551.

Gene expression databases

ArrayExpressO60551.
CleanExHS_NMT2.
GermOnlineENSG00000152465. Homo sapiens.

Family and domain databases

InterProIPR016181. Acyl_CoA_acyltransferase.
IPR000903. Myristoyl_trans.
[Graphical view]
Gene3DG3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 2 hits.
PANTHERPTHR11377. Myristoyl_trans. 1 hit.
PfamPF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view]
PIRSFPIRSF015892. N-myristl_transf. 1 hit.
PROSITEPS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio35199.
SOURCESearch...

Entry information

Entry nameNMT2_HUMAN
AccessionPrimary (citable) accession number: O60551
Secondary accession number(s): Q53Y38, Q5VUC8, Q9BRB4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 25, 2008
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents