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Protein

Forkhead box protein D2

Gene

FOXD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable transcription factor involved in embryogenesis and somatogenesis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi126 – 217Fork-headPROSITE-ProRule annotationAdd BLAST92

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D2
Alternative name(s):
Forkhead-related protein FKHL17
Forkhead-related transcription factor 9
Short name:
FREAC-9
Gene namesi
Name:FOXD2
Synonyms:FKHL17, FREAC9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:3803. FOXD2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi2306.
OpenTargetsiENSG00000186564.
PharmGKBiPA28220.

Polymorphism and mutation databases

BioMutaiFOXD2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918151 – 495Forkhead box protein D2Add BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei96PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO60548.
PeptideAtlasiO60548.
PRIDEiO60548.

PTM databases

iPTMnetiO60548.
PhosphoSitePlusiO60548.

Expressioni

Tissue specificityi

Kidney specific.1 Publication

Gene expression databases

BgeeiENSG00000186564.
CleanExiHS_FOXD2.
GenevisibleiO60548. HS.

Interactioni

Protein-protein interaction databases

BioGridi108595. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliO60548.
SMRiO60548.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi227 – 353Pro-richAdd BLAST127
Compositional biasi247 – 464Ala-richAdd BLAST218
Compositional biasi342 – 447Gly-richAdd BLAST106

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000231285.
InParanoidiO60548.
KOiK09397.
OMAiCEIMSSE.
OrthoDBiEOG091G0HW9.
PhylomeDBiO60548.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00250. Forkhead. 1 hit.
PRINTSiPR00053. FORKHEAD.
SMARTiView protein in SMART
SM00339. FH. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.

Sequencei

Sequence statusi: Complete.

O60548-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLGSCCCEI MSSESSPAAL SEADADIDVV GGGSGGGELP ARSGPRAPRD
60 70 80 90 100
VLPHGHEPPA EEAEADLAED EEESGGCSDG EPRALASRGA AAAAGSPGPG
110 120 130 140 150
AAAARGAAGP GPGPPSGGAA TRSPLVKPPY SYIALITMAI LQSPKKRLTL
160 170 180 190 200
SEICEFISGR FPYYREKFPA WQNSIRHNLS LNDCFVKIPR EPGNPGKGNY
210 220 230 240 250
WTLDPESADM FDNGSFLRRR KRFKRQPLPP PHPHPHPHPE LLLRGGAAAA
260 270 280 290 300
GDPGAFLPGF AAYGAYGYGY GLALPAYGAP PPGPAPHPHP HPHAFAFAAA
310 320 330 340 350
AAAAPCQLSV PPGRAAAPPP GPPTASVFAG AGSAPAPAPA SGSGPGPGPA
360 370 380 390 400
GLPAFLGAEL GCAKAFYAAS LSPPAAGTAA GLPTALLRQG LKTDAGGGAG
410 420 430 440 450
GGGAGAGQRP SFSIDHIMGH GGGGAAPPGA GEGSPGPPFA AAAGPGGQAQ
460 470 480 490
VLAMLTAPAL APVAGHIRLS HPGDALLSSG SRFASKVAGL SGCHF
Length:495
Mass (Da):48,748
Last modified:February 26, 2008 - v2
Checksum:iE905950E1FA94565
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti293H → HPH in AAC15421 (PubMed:9403061).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061185368A → P1 PublicationCorresponds to variant dbSNP:rs2405913Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042832 mRNA. Translation: AAC15421.1.
AL607122 Genomic DNA. No translation available.
CCDSiCCDS30708.1.
RefSeqiNP_004465.3. NM_004474.3.
UniGeneiHs.166188.

Genome annotation databases

EnsembliENST00000334793; ENSP00000335493; ENSG00000186564.
GeneIDi2306.
KEGGihsa:2306.
UCSCiuc001crm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFOXD2_HUMAN
AccessioniPrimary (citable) accession number: O60548
Secondary accession number(s): Q5SVZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 26, 2008
Last modified: August 30, 2017
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot