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O60548

- FOXD2_HUMAN

UniProt

O60548 - FOXD2_HUMAN

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Protein

Forkhead box protein D2

Gene

FOXD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Probable transcription factor involved in embryogenesis and somatogenesis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi126 – 21792Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D2
Alternative name(s):
Forkhead-related protein FKHL17
Forkhead-related transcription factor 9
Short name:
FREAC-9
Gene namesi
Name:FOXD2
Synonyms:FKHL17, FREAC9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:3803. FOXD2.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28220.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 495495Forkhead box protein D2PRO_0000091815Add
BLAST

Proteomic databases

PaxDbiO60548.
PRIDEiO60548.

PTM databases

PhosphoSiteiO60548.

Expressioni

Tissue specificityi

Kidney specific.1 Publication

Gene expression databases

BgeeiO60548.
CleanExiHS_FOXD2.
GenevestigatoriO60548.

Interactioni

Protein-protein interaction databases

BioGridi108595. 2 interactions.
STRINGi9606.ENSP00000335493.

Structurei

3D structure databases

ProteinModelPortaliO60548.
SMRiO60548. Positions 126-222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi227 – 353127Pro-richAdd
BLAST
Compositional biasi247 – 464218Ala-richAdd
BLAST
Compositional biasi342 – 447106Gly-richAdd
BLAST

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000231285.
InParanoidiO60548.
KOiK09397.
OMAiCEIMSSE.
OrthoDBiEOG7C8GHD.
PhylomeDBiO60548.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60548 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLGSCCCEI MSSESSPAAL SEADADIDVV GGGSGGGELP ARSGPRAPRD
60 70 80 90 100
VLPHGHEPPA EEAEADLAED EEESGGCSDG EPRALASRGA AAAAGSPGPG
110 120 130 140 150
AAAARGAAGP GPGPPSGGAA TRSPLVKPPY SYIALITMAI LQSPKKRLTL
160 170 180 190 200
SEICEFISGR FPYYREKFPA WQNSIRHNLS LNDCFVKIPR EPGNPGKGNY
210 220 230 240 250
WTLDPESADM FDNGSFLRRR KRFKRQPLPP PHPHPHPHPE LLLRGGAAAA
260 270 280 290 300
GDPGAFLPGF AAYGAYGYGY GLALPAYGAP PPGPAPHPHP HPHAFAFAAA
310 320 330 340 350
AAAAPCQLSV PPGRAAAPPP GPPTASVFAG AGSAPAPAPA SGSGPGPGPA
360 370 380 390 400
GLPAFLGAEL GCAKAFYAAS LSPPAAGTAA GLPTALLRQG LKTDAGGGAG
410 420 430 440 450
GGGAGAGQRP SFSIDHIMGH GGGGAAPPGA GEGSPGPPFA AAAGPGGQAQ
460 470 480 490
VLAMLTAPAL APVAGHIRLS HPGDALLSSG SRFASKVAGL SGCHF
Length:495
Mass (Da):48,748
Last modified:February 26, 2008 - v2
Checksum:iE905950E1FA94565
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti293 – 2931H → HPH in AAC15421. (PubMed:9403061)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti368 – 3681A → P.1 Publication
Corresponds to variant rs2405913 [ dbSNP | Ensembl ].
VAR_061185

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF042832 mRNA. Translation: AAC15421.1.
AL607122 Genomic DNA. Translation: CAI14974.1.
CCDSiCCDS30708.1.
RefSeqiNP_004465.3. NM_004474.3.
UniGeneiHs.166188.

Genome annotation databases

EnsembliENST00000334793; ENSP00000335493; ENSG00000186564.
GeneIDi2306.
KEGGihsa:2306.
UCSCiuc001crm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF042832 mRNA. Translation: AAC15421.1 .
AL607122 Genomic DNA. Translation: CAI14974.1 .
CCDSi CCDS30708.1.
RefSeqi NP_004465.3. NM_004474.3.
UniGenei Hs.166188.

3D structure databases

ProteinModelPortali O60548.
SMRi O60548. Positions 126-222.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108595. 2 interactions.
STRINGi 9606.ENSP00000335493.

PTM databases

PhosphoSitei O60548.

Proteomic databases

PaxDbi O60548.
PRIDEi O60548.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000334793 ; ENSP00000335493 ; ENSG00000186564 .
GeneIDi 2306.
KEGGi hsa:2306.
UCSCi uc001crm.3. human.

Organism-specific databases

CTDi 2306.
GeneCardsi GC01P047901.
HGNCi HGNC:3803. FOXD2.
MIMi 602211. gene.
neXtProti NX_O60548.
PharmGKBi PA28220.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5025.
GeneTreei ENSGT00760000118904.
HOGENOMi HOG000231285.
InParanoidi O60548.
KOi K09397.
OMAi CEIMSSE.
OrthoDBi EOG7C8GHD.
PhylomeDBi O60548.
TreeFami TF316127.

Miscellaneous databases

GenomeRNAii 2306.
NextBioi 9367.
PROi O60548.
SOURCEi Search...

Gene expression databases

Bgeei O60548.
CleanExi HS_FOXD2.
Genevestigatori O60548.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of freac-9 (FKHL17), a novel kidney-expressed human forkhead gene that maps to chromosome 1p32-p34."
    Ernstsson S., Betz R., Lagercrantz S., Larsson C., Ericksson S., Cederberg A., Carlsson P., Enerbaeck S.
    Genomics 46:78-85(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT PRO-368.
  2. Enerbaeck S.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiFOXD2_HUMAN
AccessioniPrimary (citable) accession number: O60548
Secondary accession number(s): Q5SVZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 26, 2008
Last modified: October 29, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3