Reviewed, UniProtKB/Swiss-Prot O60543 (CIDEA_HUMAN)

Names and origin

Protein names

Recommended name:
    Cell death activator CIDE-A
Alternative name(s):
    Cell death-inducing DFFA-like effector A

Gene names

Name:

CIDEA

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Activates apoptosis.
Subunit structure	Inhibited by DFFB.
Sequence similarities	Contains 1 CIDE-N domain.

Ontologies

Keywords
Biological process	Apoptosis
Coding sequence diversity	Polymorphism
Technical term	3D-structure
Gene Ontology (GO)
Biological process	DNA damage response, signal transduction resulting in induction of apoptosis Ref.1 Traceable author statement. Source: ProtInc DNA fragmentation involved in apoptosis Ref.1 Inferred from sequence or structural similarity. Source: UniProtKB lipid metabolic process Inferred from sequence or structural similarity. Source: UniProtKB lipid storage Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of apoptosis Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of cytokine secretion Inferred from mutant phenotype. Source: UniProtKB negative regulation of lipid catabolic process Inferred from mutant phenotype. Source: UniProtKB negative regulation of transforming growth factor beta receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of tumor necrosis factor production Inferred from mutant phenotype. Source: UniProtKB temperature homeostasis Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	mitochondrial envelope Inferred from sequence or structural similarity. Source: UniProtKB nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	protein homodimerization activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 219

219

Cell death activator CIDE-A

PRO_0000144718

Regions

Domain

33 – 110

78

CIDE-N

Natural variations

Natural variant

115

1

V → F: dbSNP rs45619832.

VAR_048738

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

219

Helix Strand Turn

Details...

Beta strand

35 – 40

6

Beta strand

48 – 54

7

Helix

55 – 65

11

Beta strand

69 – 71

3

Beta strand

73 – 77

5

Turn

78 – 80

3

Helix

87 – 90

4

Beta strand

95 – 103

9

Sequences

	Sequence		Length	Mass (Da)
	O60543-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 05F704823CE71C0E	FASTA	219	24,687
	10 20 30 40 50 60 MEAARDYAGA LIRPLTFMGS QTKRVLFTPL MHPARPFRVS NHDRSSRRGV MASSLQELIS 70 80 90 100 110 120 KTLDALVIAT GLVTLVLEED GTVVDTEEFF QTLGDNTHFM ILEKGQKWMP GSQHVPTCSP 130 140 150 160 170 180 PKRSGIARVT FDLYRLNPKD FIGCLNVKAT MYEMYSVSYD IRCTGLKGLL RSLLRFLSYS 190 200 210 AQVTGQFLIY LGTYMLRVLD DKEERPSLRS QAKGRFTCG

References

[1]	"CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor." Inohara N., Koseki T., Chen S., Wu X., Nunez G. EMBO J. 17:2526-2533(1998) [PubMed: 9564035] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	NHLBI resequencing and genotyping service (RS&G) Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Solution structure of the CIDE-N domain of human cell death activator CIDE-A." RIKEN structural genomics initiative (RSGI) Submitted (AUG-2007) to the PDB data bank Cited for: STRUCTURE BY NMR OF 33-110.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AF041378 mRNA. Translation: AAC34987.1.
EF444967 Genomic DNA. Translation: ACA05966.1.

IPI

IPI00030204.

RefSeq

NP_001270.1.

UniGene

Hs.249129

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2EEL	NMR	-	A	33-110	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

O60543. 1 interaction.

PTM databases

PhosphoSite

O60543.

Proteomic databases

PRIDE

O60543.

Genome annotation databases

Ensembl

ENSG00000176194. Homo sapiens. [Contig view]

GeneID

1149.

KEGG

hsa:1149.

Organism-specific databases

GeneCards

GC18P012244.

H-InvDB

HIX0020149.

HGNC

HGNC:1976. CIDEA.

MIM

604440. gene.

PharmGKB

PA26514.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

O60543.

Gene expression databases

ArrayExpress

O60543.

Bgee

O60543.

CleanEx

HS_CIDEA.

GermOnline

ENSG00000176194. Homo sapiens.

Family and domain databases

InterPro

IPR003508. CAD.
[Graphical view]

Pfam

PF02017. CIDE-N. 1 hit.
[Graphical view]

SMART

SM00266. CAD. 1 hit.
[Graphical view]

PROSITE

PS51135. CIDE_N. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

4776.

SOURCE

Search...

Entry information

Entry name

CIDEA_HUMAN

Accession

Primary (citable) accession number: O60543
Secondary accession number(s): B0YIY7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	August 1, 1998
Last modified:	June 16, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)