ID   PSPN_HUMAN              Reviewed;         156 AA.
AC   O60542;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   24-JAN-2024, entry version 160.
DE   RecName: Full=Persephin;
DE            Short=PSP;
DE   Flags: Precursor;
GN   Name=PSPN;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9491986; DOI=10.1016/s0896-6273(00)80453-5;
RA   Milbrandt J., de Sauvage F.J., Fahrner T.J., Baloh R.H., Leitner M.L.,
RA   Tansey M.G., Lampe P.A., Heuckeroth R.O., Kotzbauer P.T., Simburger K.S.,
RA   Golden J.P., Davies J.A., Vejsada R., Kato A.C., Hynes M., Sherman D.,
RA   Nishimura M., Wang L.-C., Vandlen R., Moffat B., Klein R.D., Poulsen K.,
RA   Gray C., Garces A., Henderson C.E., Phillips H.S., Johnson E.M.;
RT   "Persephin, a novel neurotrophic factor related to GDNF and neurturin.";
RL   Neuron 20:245-253(1998).
CC   -!- FUNCTION: Exhibits neurotrophic activity on mesencephalic dopaminergic
CC       and motor neurons.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF040962; AAC39640.1; -; mRNA.
DR   CCDS; CCDS12164.1; -.
DR   RefSeq; NP_004149.1; NM_004158.3.
DR   AlphaFoldDB; O60542; -.
DR   SMR; O60542; -.
DR   BioGRID; 111607; 31.
DR   STRING; 9606.ENSP00000245810; -.
DR   iPTMnet; O60542; -.
DR   PhosphoSitePlus; O60542; -.
DR   BioMuta; PSPN; -.
DR   MassIVE; O60542; -.
DR   PaxDb; 9606-ENSP00000245810; -.
DR   Antibodypedia; 42539; 257 antibodies from 26 providers.
DR   DNASU; 5623; -.
DR   Ensembl; ENST00000245810.2; ENSP00000245810.1; ENSG00000125650.5.
DR   GeneID; 5623; -.
DR   KEGG; hsa:5623; -.
DR   MANE-Select; ENST00000245810.2; ENSP00000245810.1; NM_004158.5; NP_004149.1.
DR   UCSC; uc010xja.2; human.
DR   AGR; HGNC:9579; -.
DR   CTD; 5623; -.
DR   DisGeNET; 5623; -.
DR   GeneCards; PSPN; -.
DR   HGNC; HGNC:9579; PSPN.
DR   HPA; ENSG00000125650; Low tissue specificity.
DR   MIM; 602921; gene.
DR   neXtProt; NX_O60542; -.
DR   OpenTargets; ENSG00000125650; -.
DR   PharmGKB; PA33930; -.
DR   VEuPathDB; HostDB:ENSG00000125650; -.
DR   eggNOG; ENOG502S9IE; Eukaryota.
DR   GeneTree; ENSGT00950000182993; -.
DR   HOGENOM; CLU_102221_2_0_1; -.
DR   InParanoid; O60542; -.
DR   OMA; TFRYCAG; -.
DR   OrthoDB; 4316464at2759; -.
DR   PhylomeDB; O60542; -.
DR   TreeFam; TF332366; -.
DR   PathwayCommons; O60542; -.
DR   Reactome; R-HSA-419037; NCAM1 interactions.
DR   Reactome; R-HSA-5673001; RAF/MAP kinase cascade.
DR   Reactome; R-HSA-8853659; RET signaling.
DR   SignaLink; O60542; -.
DR   SIGNOR; O60542; -.
DR   BioGRID-ORCS; 5623; 11 hits in 1147 CRISPR screens.
DR   GenomeRNAi; 5623; -.
DR   Pharos; O60542; Tbio.
DR   PRO; PR:O60542; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; O60542; Protein.
DR   Bgee; ENSG00000125650; Expressed in primordial germ cell in gonad and 99 other cell types or tissues.
DR   ExpressionAtlas; O60542; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0030116; F:glial cell-derived neurotrophic factor receptor binding; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:InterPro.
DR   GO; GO:0005102; F:signaling receptor binding; TAS:ProtInc.
DR   GO; GO:0007417; P:central nervous system development; TAS:ProtInc.
DR   GO; GO:0007399; P:nervous system development; TAS:ProtInc.
DR   CDD; cd19382; TGF_beta_Persephin; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR043401; GDNF_fam.
DR   InterPro; IPR001839; TGF-b_C.
DR   PANTHER; PTHR12173; GDNF SUBFAMILY OF TGF-BETA FAMILY; 1.
DR   PANTHER; PTHR12173:SF8; PERSEPHIN; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
DR   Genevisible; O60542; HS.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Growth factor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..156
FT                   /note="Persephin"
FT                   /id="PRO_0000034014"
FT   DISULFID        66..124
FT                   /evidence="ECO:0000250"
FT   DISULFID        93..152
FT                   /evidence="ECO:0000250"
FT   DISULFID        97..154
FT                   /evidence="ECO:0000250"
FT   DISULFID        123
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   156 AA;  16600 MW;  6547751653A7044A CRC64;
     MAVGKFLLGS LLLLSLQLGQ GWGPDARGVP VADGEFSSEQ VAKAGGTWLG THRPLARLRR
     ALSGPCQLWS LTLSVAELGL GYASEEKVIF RYCAGSCPRG ARTQHGLALA RLQGQGRAHG
     GPCCRPTRYT DVAFLDDRHR WQRLPQLSAA ACGCGG
//