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O60542

- PSPN_HUMAN

UniProt

O60542 - PSPN_HUMAN

Protein

Persephin

Gene

PSPN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons.

    GO - Molecular functioni

    1. receptor binding Source: ProtInc

    GO - Biological processi

    1. axon guidance Source: Reactome
    2. branching involved in ureteric bud morphogenesis Source: Ensembl
    3. central nervous system development Source: ProtInc
    4. nervous system development Source: ProtInc

    Keywords - Molecular functioni

    Growth factor

    Enzyme and pathway databases

    ReactomeiREACT_18312. NCAM1 interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Persephin
    Short name:
    PSP
    Gene namesi
    Name:PSPN
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:9579. PSPN.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33930.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 156135PersephinPRO_0000034014Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi66 ↔ 124By similarity
    Disulfide bondi93 ↔ 152By similarity
    Disulfide bondi97 ↔ 154By similarity
    Disulfide bondi123 – 123InterchainBy similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiO60542.
    PRIDEiO60542.

    Expressioni

    Gene expression databases

    ArrayExpressiO60542.
    BgeeiO60542.
    CleanExiHS_PSPN.
    GenevestigatoriO60542.

    Organism-specific databases

    HPAiCAB025366.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.By similarity

    Protein-protein interaction databases

    BioGridi111607. 2 interactions.
    STRINGi9606.ENSP00000245810.

    Structurei

    3D structure databases

    ProteinModelPortaliO60542.
    SMRiO60542. Positions 66-156.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family. GDNF subfamily.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44090.
    HOGENOMiHOG000220877.
    HOVERGENiHBG008316.
    InParanoidiO60542.
    OMAiAPAGPCQ.
    PhylomeDBiO60542.
    TreeFamiTF332366.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    [Graphical view]
    PfamiPF00019. TGF_beta. 1 hit.
    [Graphical view]
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O60542-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVGKFLLGS LLLLSLQLGQ GWGPDARGVP VADGEFSSEQ VAKAGGTWLG    50
    THRPLARLRR ALSGPCQLWS LTLSVAELGL GYASEEKVIF RYCAGSCPRG 100
    ARTQHGLALA RLQGQGRAHG GPCCRPTRYT DVAFLDDRHR WQRLPQLSAA 150
    ACGCGG 156
    Length:156
    Mass (Da):16,600
    Last modified:August 1, 1998 - v1
    Checksum:i6547751653A7044A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF040962 mRNA. Translation: AAC39640.1.
    CCDSiCCDS12164.1.
    RefSeqiNP_004149.1. NM_004158.2.
    UniGeneiHs.248159.

    Genome annotation databases

    EnsembliENST00000245810; ENSP00000245810; ENSG00000125650.
    GeneIDi5623.
    KEGGihsa:5623.
    UCSCiuc010xja.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF040962 mRNA. Translation: AAC39640.1 .
    CCDSi CCDS12164.1.
    RefSeqi NP_004149.1. NM_004158.2.
    UniGenei Hs.248159.

    3D structure databases

    ProteinModelPortali O60542.
    SMRi O60542. Positions 66-156.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111607. 2 interactions.
    STRINGi 9606.ENSP00000245810.

    Proteomic databases

    PaxDbi O60542.
    PRIDEi O60542.

    Protocols and materials databases

    DNASUi 5623.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000245810 ; ENSP00000245810 ; ENSG00000125650 .
    GeneIDi 5623.
    KEGGi hsa:5623.
    UCSCi uc010xja.2. human.

    Organism-specific databases

    CTDi 5623.
    GeneCardsi GC19M006375.
    HGNCi HGNC:9579. PSPN.
    HPAi CAB025366.
    MIMi 602921. gene.
    neXtProti NX_O60542.
    PharmGKBi PA33930.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44090.
    HOGENOMi HOG000220877.
    HOVERGENi HBG008316.
    InParanoidi O60542.
    OMAi APAGPCQ.
    PhylomeDBi O60542.
    TreeFami TF332366.

    Enzyme and pathway databases

    Reactomei REACT_18312. NCAM1 interactions.

    Miscellaneous databases

    GenomeRNAii 5623.
    NextBioi 21856.
    PROi O60542.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60542.
    Bgeei O60542.
    CleanExi HS_PSPN.
    Genevestigatori O60542.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    [Graphical view ]
    Pfami PF00019. TGF_beta. 1 hit.
    [Graphical view ]
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiPSPN_HUMAN
    AccessioniPrimary (citable) accession number: O60542
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3