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O60542 (PSPN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Persephin

Short name=PSP
Gene names
Name:PSPN
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length156 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons.

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the TGF-beta family. GDNF subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 156135Persephin
PRO_0000034014

Amino acid modifications

Disulfide bond66 ↔ 124 By similarity
Disulfide bond93 ↔ 152 By similarity
Disulfide bond97 ↔ 154 By similarity
Disulfide bond123Interchain By similarity

Sequences

Sequence LengthMass (Da)Tools
O60542 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 6547751653A7044A

FASTA15616,600
        10         20         30         40         50         60 
MAVGKFLLGS LLLLSLQLGQ GWGPDARGVP VADGEFSSEQ VAKAGGTWLG THRPLARLRR 

        70         80         90        100        110        120 
ALSGPCQLWS LTLSVAELGL GYASEEKVIF RYCAGSCPRG ARTQHGLALA RLQGQGRAHG 

       130        140        150 
GPCCRPTRYT DVAFLDDRHR WQRLPQLSAA ACGCGG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF040962 mRNA. Translation: AAC39640.1.
CCDSCCDS12164.1.
RefSeqNP_004149.1. NM_004158.2.
UniGeneHs.248159.

3D structure databases

ProteinModelPortalO60542.
SMRO60542. Positions 66-156.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111607. 2 interactions.
STRING9606.ENSP00000245810.

Proteomic databases

PaxDbO60542.
PRIDEO60542.

Protocols and materials databases

DNASU5623.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000245810; ENSP00000245810; ENSG00000125650.
GeneID5623.
KEGGhsa:5623.
UCSCuc010xja.2. human.

Organism-specific databases

CTD5623.
GeneCardsGC19M006375.
HGNCHGNC:9579. PSPN.
HPACAB025366.
MIM602921. gene.
neXtProtNX_O60542.
PharmGKBPA33930.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44090.
HOGENOMHOG000220877.
HOVERGENHBG008316.
InParanoidO60542.
OMAAPAGPCQ.
PhylomeDBO60542.
TreeFamTF332366.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.

Gene expression databases

ArrayExpressO60542.
BgeeO60542.
CleanExHS_PSPN.
GenevestigatorO60542.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
[Graphical view]
PfamPF00019. TGF_beta. 1 hit.
[Graphical view]
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
PROSITEPS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi5623.
NextBio21856.
PROO60542.
SOURCESearch...

Entry information

Entry namePSPN_HUMAN
AccessionPrimary (citable) accession number: O60542
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM