O60542 (PSPN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Persephin
Short name=PSP

Gene names

Name:

PSPN

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	156 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons.
Subunit structure	Homodimer; disulfide-linked By similarity.
Subcellular location	Secreted.
Sequence similarities	Belongs to the TGF-beta family. GDNF subfamily.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Growth factor
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Traceable author statement. Source: Reactome branching involved in ureteric bud morphogenesis Inferred from electronic annotation. Source: Compara central nervous system development Traceable author statement Ref.1. Source: ProtInc
Cellular_component	extracellular space Inferred from electronic annotation. Source: Compara
Molecular_function	receptor binding Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 156	135	Persephin		PRO_0000034014
Amino acid modifications
	Disulfide bond	66 ↔ 124		By similarity
	Disulfide bond	93 ↔ 152		By similarity
	Disulfide bond	97 ↔ 154		By similarity
	Disulfide bond	123		Interchain By similarity

Sequences

	Sequence		Length	Mass (Da)
	O60542 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 6547751653A7044A	FASTA	156	16,600
	10 20 30 40 50 60 MAVGKFLLGS LLLLSLQLGQ GWGPDARGVP VADGEFSSEQ VAKAGGTWLG THRPLARLRR 70 80 90 100 110 120 ALSGPCQLWS LTLSVAELGL GYASEEKVIF RYCAGSCPRG ARTQHGLALA RLQGQGRAHG 130 140 150 GPCCRPTRYT DVAFLDDRHR WQRLPQLSAA ACGCGG

References

[1]

"Persephin, a novel neurotrophic factor related to GDNF and neurturin." Milbrandt J., de Sauvage F.J., Fahrner T.J., Baloh R.H., Leitner M.L., Tansey M.G., Lampe P.A., Heuckeroth R.O., Kotzbauer P.T., Simburger K.S., Golden J.P., Davies J.A., Vejsada R., Kato A.C., Hynes M., Sherman D., Nishimura M., Wang L.-C. , Vandlen R., Moffat B., Klein R.D., Poulsen K., Gray C., Garces A., Henderson C.E., Phillips H.S., Johnson E.M. Neuron 20:245-253(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF040962 mRNA. Translation: AAC39640.1.
IPI	IPI01010579.
RefSeq	NP_004149.1. NM_004158.2.
UniGene	Hs.248159.
3D structure databases
ProteinModelPortal	O60542.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000245810.
Proteomic databases
PaxDb	O60542.
PRIDE	O60542.
Protocols and materials databases
DNASU	5623.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000245810; ENSP00000245810; ENSG00000125650.
GeneID	5623.
KEGG	hsa:5623.
UCSC	uc010xja.2. human.
Organism-specific databases
CTD	5623.
GeneCards	GC19M006326.
HGNC	HGNC:9579. PSPN.
HPA	CAB025366.
MIM	602921. gene.
neXtProt	NX_O60542.
PharmGKB	PA33930.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG44090.
HOGENOM	HOG000220877.
HOVERGEN	HBG008316.
InParanoid	O60542.
OMA	YASEEKV.
OrthoDB	EOG437RGC.
PhylomeDB	O60542.
Enzyme and pathway databases
Reactome	REACT_111045. Developmental Biology.
Gene expression databases
Bgee	O60542.
CleanEx	HS_PSPN.
Genevestigator	O60542.
GermOnline	ENSG00000125650. Homo sapiens.
Family and domain databases
InterPro	IPR001839. TGF-b_C. [Graphical view]
Pfam	PF00019. TGF_beta. 1 hit. [Graphical view]
SMART	SM00204. TGFB. 1 hit. [Graphical view]
PROSITE	PS00250. TGF_BETA_1. False negative. PS51362. TGF_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	5623.
NextBio	21856.
SOURCE	Search...

Entry information

Entry name

PSPN_HUMAN

Accession

Primary (citable) accession number: O60542

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 1, 1998
Last modified:	May 1, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.