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Protein

Persephin

Gene

PSPN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons.

GO - Molecular functioni

  1. receptor binding Source: ProtInc

GO - Biological processi

  1. axon guidance Source: Reactome
  2. branching involved in ureteric bud morphogenesis Source: Ensembl
  3. central nervous system development Source: ProtInc
  4. nervous system development Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_18312. NCAM1 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Persephin
Short name:
PSP
Gene namesi
Name:PSPN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:9579. PSPN.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33930.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 156135PersephinPRO_0000034014Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi66 ↔ 124By similarity
Disulfide bondi93 ↔ 152By similarity
Disulfide bondi97 ↔ 154By similarity
Disulfide bondi123 – 123InterchainBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO60542.
PRIDEiO60542.

Expressioni

Gene expression databases

BgeeiO60542.
CleanExiHS_PSPN.
ExpressionAtlasiO60542. baseline and differential.
GenevestigatoriO60542.

Organism-specific databases

HPAiCAB025366.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

BioGridi111607. 2 interactions.
STRINGi9606.ENSP00000245810.

Structurei

3D structure databases

ProteinModelPortaliO60542.
SMRiO60542. Positions 66-156.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family. GDNF subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44090.
GeneTreeiENSGT00520000055559.
HOGENOMiHOG000220877.
HOVERGENiHBG008316.
InParanoidiO60542.
OMAiYASEEKV.
PhylomeDBiO60542.
TreeFamiTF332366.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
[Graphical view]
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60542-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVGKFLLGS LLLLSLQLGQ GWGPDARGVP VADGEFSSEQ VAKAGGTWLG
60 70 80 90 100
THRPLARLRR ALSGPCQLWS LTLSVAELGL GYASEEKVIF RYCAGSCPRG
110 120 130 140 150
ARTQHGLALA RLQGQGRAHG GPCCRPTRYT DVAFLDDRHR WQRLPQLSAA

ACGCGG
Length:156
Mass (Da):16,600
Last modified:August 1, 1998 - v1
Checksum:i6547751653A7044A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040962 mRNA. Translation: AAC39640.1.
CCDSiCCDS12164.1.
RefSeqiNP_004149.1. NM_004158.2.
UniGeneiHs.248159.

Genome annotation databases

EnsembliENST00000245810; ENSP00000245810; ENSG00000125650.
GeneIDi5623.
KEGGihsa:5623.
UCSCiuc010xja.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040962 mRNA. Translation: AAC39640.1.
CCDSiCCDS12164.1.
RefSeqiNP_004149.1. NM_004158.2.
UniGeneiHs.248159.

3D structure databases

ProteinModelPortaliO60542.
SMRiO60542. Positions 66-156.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111607. 2 interactions.
STRINGi9606.ENSP00000245810.

Proteomic databases

PaxDbiO60542.
PRIDEiO60542.

Protocols and materials databases

DNASUi5623.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245810; ENSP00000245810; ENSG00000125650.
GeneIDi5623.
KEGGihsa:5623.
UCSCiuc010xja.2. human.

Organism-specific databases

CTDi5623.
GeneCardsiGC19M006375.
HGNCiHGNC:9579. PSPN.
HPAiCAB025366.
MIMi602921. gene.
neXtProtiNX_O60542.
PharmGKBiPA33930.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG44090.
GeneTreeiENSGT00520000055559.
HOGENOMiHOG000220877.
HOVERGENiHBG008316.
InParanoidiO60542.
OMAiYASEEKV.
PhylomeDBiO60542.
TreeFamiTF332366.

Enzyme and pathway databases

ReactomeiREACT_18312. NCAM1 interactions.

Miscellaneous databases

GenomeRNAii5623.
NextBioi21856.
PROiO60542.
SOURCEiSearch...

Gene expression databases

BgeeiO60542.
CleanExiHS_PSPN.
ExpressionAtlasiO60542. baseline and differential.
GenevestigatoriO60542.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
[Graphical view]
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPSPN_HUMAN
AccessioniPrimary (citable) accession number: O60542
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: January 7, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.