O60524 (NEMF_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nuclear export mediator factor NEMF

Alternative name(s):
Antigen NY-CO-1
Serologically defined colon cancer antigen 1

Gene names

Name:	NEMF
Synonyms:	SDCCAG1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1076 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in nuclear export. Ref.6
Subunit structure	Interacts (via its N-terminus) with XPO1 By similarity.
Subcellular location	Nucleus Potential.
Tissue specificity	Expressed in brain, heart, liver, lung, spleen, and skeletal muscle. Also expressed at lower levels in stomach and testis. Ref.6
Domain	The N-terminal domain contains a nuclear export signal. The C-terminal domain may interact with cargo proteins By similarity.
Miscellaneous	Active in normal lung tissue, but is inactive in several lung cancer cell lines.
Sequence similarities	Belongs to the NEMF family.
Sequence caution	The sequence AAC18036.1 differs from that shown. Reason: Frameshift at position 1065. The sequence AAH06001.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence AAH20794.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH56687.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence AAI07765.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAG52763.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAG58070.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame. The sequence BAG58070.1 differs from that shown. Reason: Frameshift at positions 246 and 1025. The sequence BAG58070.1 differs from that shown. Reason: Intron retention.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O60524-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O60524-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MKSRFSTIDLRAVLAELNASL → MPKTCQCYVGTKTTNPSAWPS
     22-821: Missing.

Isoform 3 (identifier: O60524-3)

The sequence of this isoform differs from the canonical sequence as follows:
     562-582: Missing.

Isoform 4 (identifier: O60524-4)

The sequence of this isoform differs from the canonical sequence as follows:
     78-119: Missing.

Isoform 5 (identifier: O60524-5)

The sequence of this isoform differs from the canonical sequence as follows:
     221-245: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1076	1076	Nuclear export mediator factor NEMF		PRO_0000097642
Amino acid modifications
	Modified residue	417	1	Phosphoserine Ref.8 Ref.9
	Modified residue	692	1	Phosphoserine Ref.7
	Modified residue	703	1	Phosphothreonine Ref.7
	Modified residue	704	1	Phosphoserine Ref.7
	Modified residue	705	1	Phosphoserine Ref.7
	Modified residue	747	1	Phosphoserine Ref.7 Ref.8
	Modified residue	748	1	Phosphoserine Ref.7 Ref.8
Natural variations
	Alternative sequence	1 – 21	21	MKSRF…LNASL → MPKTCQCYVGTKTTNPSAWP S in isoform 2.		VSP_008396
	Alternative sequence	22 – 821	800	Missing in isoform 2.		VSP_010462
	Alternative sequence	78 – 119	42	Missing in isoform 4.		VSP_041064
	Alternative sequence	221 – 245	25	Missing in isoform 5.		VSP_041065
	Alternative sequence	562 – 582	21	Missing in isoform 3.		VSP_041066
	Natural variant	257	1	S → C. Ref.1 Ref.4 Corresponds to variant rs3100906 [ dbSNP | Ensembl ].		VAR_034488
Experimental info
	Sequence conflict	53	1	E → K in BAG56774. Ref.1
	Sequence conflict	438	1	P → S in AAH56687. Ref.4
	Sequence conflict	495	1	E → G in BAG56774. Ref.1
	Sequence conflict	560	1	P → PV in BAG58070. Ref.1
	Sequence conflict	593	1	A → V in CAE45889. Ref.2
	Sequence conflict	696	1	E → K in BAG65465. Ref.1
	Sequence conflict	766	1	E → V in BX648753. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 24, 2009. Version 4. Checksum: FCC5F95A0DB22F79	FASTA	1,076	122,954
	10 20 30 40 50 60 MKSRFSTIDL RAVLAELNAS LLGMRVNNVY DVDNKTYLIR LQKPDFKATL LLESGIRIHT 70 80 90 100 110 120 TEFEWPKNMM PSSFAMKCRK HLKSRRLVSA KQLGVDRIVD FQFGSDEAAY HLIIELYDRG 130 140 150 160 170 180 NIVLTDYEYV ILNILRFRTD EADDVKFAVR ERYPLDHARA AEPLLTLERL TEIVASAPKG 190 200 210 220 230 240 ELLKRVLNPL LPYGPALIEH CLLENGFSGN VKVDEKLETK DIEKVLVSLQ KAEDYMKTTS 250 260 270 280 290 300 NFSGKGYIIQ KREIKPSLEA DKPVEDILTY EEFHPFLFSQ HSQCPYIEFE SFDKAVDEFY 310 320 330 340 350 360 SKIEGQKIDL KALQQEKQAL KKLDNVRKDH ENRLEALQQA QEIDKLKGEL IEMNLQIVDR 370 380 390 400 410 420 AIQVVRSALA NQIDWTEIGL IVKEAQAQGD PVASAIKELK LQTNHVTMLL RNPYLLSEEE 430 440 450 460 470 480 DDDVDGDVNV EKNETEPPKG KKKKQKNKQL QKPQKNKPLL VDVDLSLSAY ANAKKYYDHK 490 500 510 520 530 540 RYAAKKTQKT VEAAEKAFKS AEKKTKQTLK EVQTVTSIQK ARKVYWFEKF LWFISSENYL 550 560 570 580 590 600 IIGGRDQQQN EIIVKRYLTP GDIYVHADLH GATSCVIKNP TGEPIPPRTL TEAGTMALCY 610 620 630 640 650 660 SAAWDARVIT SAWWVYHHQV SKTAPTGEYL TTGSFMIRGK KNFLPPSYLM MGFSFLFKVD 670 680 690 700 710 720 ESCVWRHQGE RKVRVQDEDM ETLASCTSEL ISEEMEQLDG GDTSSDEDKE EHETPVEVEL 730 740 750 760 770 780 MTQVDQEDIT LQSGRDELNE ELIQEESSED EGEYEEVRKD QDSVGEMKDE GEETLNYPDT 790 800 810 820 830 840 TIDLSHLQPQ RSIQKLASKE ESSNSSDSKS QSRRHLSAKE RREMKKKKLP SDSGDLEALE 850 860 870 880 890 900 GKDKEKESTV HIETHQNTSK NVAAVQPMKR GQKSKMKKMK EKYKDQDEED RELIMKLLGS 910 920 930 940 950 960 AGSNKEEKGK KGKKGKTKDE PVKKQPQKPR GGQRVSDNIK KETPFLEVIT HELQDFAVDD 970 980 990 1000 1010 1020 PHDDKEEQDL DQQGNEENLF DSLTGQPHPE DVLLFAIPIC APYTTMTNYK YKVKLTPGVQ 1030 1040 1050 1060 1070 KKGKAAKTAL NSFMHSKEAT AREKDLFRSV KDTDLSRNIP GKVKVSAPNL LNVKRK
	Isoform 2 [UniParc]. Checksum: 49B37757681B0E51	FASTA	276	31,151
	10 20 30 40 50 60 MPKTCQCYVG TKTTNPSAWP SREMKKKKLP SDSGDLEALE GKDKEKESTV HIETHQNTSK 70 80 90 100 110 120 NVAAVQPMKR GQKSKMKKMK EKYKDQDEED RELIMKLLGS AGSNKEEKGK KGKKGKTKDE 130 140 150 160 170 180 PVKKQPQKPR GGQRVSDNIK KETPFLEVIT HELQDFAVDD PHDDKEEQDL DQQGNEENLF 190 200 210 220 230 240 DSLTGQPHPE DVLLFAIPIC APYTTMTNYK YKVKLTPGVQ KKGKAAKTAL NSFMHSKEAT 250 260 270 AREKDLFRSV KDTDLSRNIP GKVKVSAPNL LNVKRK
	Isoform 3 [UniParc]. Checksum: 6D69BA826390F146	FASTA	1,055	120,761
	10 20 30 40 50 60 MKSRFSTIDL RAVLAELNAS LLGMRVNNVY DVDNKTYLIR LQKPDFKATL LLESGIRIHT 70 80 90 100 110 120 TEFEWPKNMM PSSFAMKCRK HLKSRRLVSA KQLGVDRIVD FQFGSDEAAY HLIIELYDRG 130 140 150 160 170 180 NIVLTDYEYV ILNILRFRTD EADDVKFAVR ERYPLDHARA AEPLLTLERL TEIVASAPKG 190 200 210 220 230 240 ELLKRVLNPL LPYGPALIEH CLLENGFSGN VKVDEKLETK DIEKVLVSLQ KAEDYMKTTS 250 260 270 280 290 300 NFSGKGYIIQ KREIKPSLEA DKPVEDILTY EEFHPFLFSQ HSQCPYIEFE SFDKAVDEFY 310 320 330 340 350 360 SKIEGQKIDL KALQQEKQAL KKLDNVRKDH ENRLEALQQA QEIDKLKGEL IEMNLQIVDR 370 380 390 400 410 420 AIQVVRSALA NQIDWTEIGL IVKEAQAQGD PVASAIKELK LQTNHVTMLL RNPYLLSEEE 430 440 450 460 470 480 DDDVDGDVNV EKNETEPPKG KKKKQKNKQL QKPQKNKPLL VDVDLSLSAY ANAKKYYDHK 490 500 510 520 530 540 RYAAKKTQKT VEAAEKAFKS AEKKTKQTLK EVQTVTSIQK ARKVYWFEKF LWFISSENYL 550 560 570 580 590 600 IIGGRDQQQN EIIVKRYLTP GEPIPPRTLT EAGTMALCYS AAWDARVITS AWWVYHHQVS 610 620 630 640 650 660 KTAPTGEYLT TGSFMIRGKK NFLPPSYLMM GFSFLFKVDE SCVWRHQGER KVRVQDEDME 670 680 690 700 710 720 TLASCTSELI SEEMEQLDGG DTSSDEDKEE HETPVEVELM TQVDQEDITL QSGRDELNEE 730 740 750 760 770 780 LIQEESSEDE GEYEEVRKDQ DSVGEMKDEG EETLNYPDTT IDLSHLQPQR SIQKLASKEE 790 800 810 820 830 840 SSNSSDSKSQ SRRHLSAKER REMKKKKLPS DSGDLEALEG KDKEKESTVH IETHQNTSKN 850 860 870 880 890 900 VAAVQPMKRG QKSKMKKMKE KYKDQDEEDR ELIMKLLGSA GSNKEEKGKK GKKGKTKDEP 910 920 930 940 950 960 VKKQPQKPRG GQRVSDNIKK ETPFLEVITH ELQDFAVDDP HDDKEEQDLD QQGNEENLFD 970 980 990 1000 1010 1020 SLTGQPHPED VLLFAIPICA PYTTMTNYKY KVKLTPGVQK KGKAAKTALN SFMHSKEATA 1030 1040 1050 REKDLFRSVK DTDLSRNIPG KVKVSAPNLL NVKRK
	Isoform 4 [UniParc]. Checksum: 8B42E666C724AB60	FASTA	1,034	118,025
	10 20 30 40 50 60 MKSRFSTIDL RAVLAELNAS LLGMRVNNVY DVDNKTYLIR LQKPDFKATL LLESGIRIHT 70 80 90 100 110 120 TEFEWPKNMM PSSFAMKGNI VLTDYEYVIL NILRFRTDEA DDVKFAVRER YPLDHARAAE 130 140 150 160 170 180 PLLTLERLTE IVASAPKGEL LKRVLNPLLP YGPALIEHCL LENGFSGNVK VDEKLETKDI 190 200 210 220 230 240 EKVLVSLQKA EDYMKTTSNF SGKGYIIQKR EIKPSLEADK PVEDILTYEE FHPFLFSQHS 250 260 270 280 290 300 QCPYIEFESF DKAVDEFYSK IEGQKIDLKA LQQEKQALKK LDNVRKDHEN RLEALQQAQE 310 320 330 340 350 360 IDKLKGELIE MNLQIVDRAI QVVRSALANQ IDWTEIGLIV KEAQAQGDPV ASAIKELKLQ 370 380 390 400 410 420 TNHVTMLLRN PYLLSEEEDD DVDGDVNVEK NETEPPKGKK KKQKNKQLQK PQKNKPLLVD 430 440 450 460 470 480 VDLSLSAYAN AKKYYDHKRY AAKKTQKTVE AAEKAFKSAE KKTKQTLKEV QTVTSIQKAR 490 500 510 520 530 540 KVYWFEKFLW FISSENYLII GGRDQQQNEI IVKRYLTPGD IYVHADLHGA TSCVIKNPTG 550 560 570 580 590 600 EPIPPRTLTE AGTMALCYSA AWDARVITSA WWVYHHQVSK TAPTGEYLTT GSFMIRGKKN 610 620 630 640 650 660 FLPPSYLMMG FSFLFKVDES CVWRHQGERK VRVQDEDMET LASCTSELIS EEMEQLDGGD 670 680 690 700 710 720 TSSDEDKEEH ETPVEVELMT QVDQEDITLQ SGRDELNEEL IQEESSEDEG EYEEVRKDQD 730 740 750 760 770 780 SVGEMKDEGE ETLNYPDTTI DLSHLQPQRS IQKLASKEES SNSSDSKSQS RRHLSAKERR 790 800 810 820 830 840 EMKKKKLPSD SGDLEALEGK DKEKESTVHI ETHQNTSKNV AAVQPMKRGQ KSKMKKMKEK 850 860 870 880 890 900 YKDQDEEDRE LIMKLLGSAG SNKEEKGKKG KKGKTKDEPV KKQPQKPRGG QRVSDNIKKE 910 920 930 940 950 960 TPFLEVITHE LQDFAVDDPH DDKEEQDLDQ QGNEENLFDS LTGQPHPEDV LLFAIPICAP 970 980 990 1000 1010 1020 YTTMTNYKYK VKLTPGVQKK GKAAKTALNS FMHSKEATAR EKDLFRSVKD TDLSRNIPGK 1030 VKVSAPNLLN VKRK
	Isoform 5 [UniParc]. Checksum: F0CA1E8446FC3739	FASTA	1,051	120,140
	10 20 30 40 50 60 MKSRFSTIDL RAVLAELNAS LLGMRVNNVY DVDNKTYLIR LQKPDFKATL LLESGIRIHT 70 80 90 100 110 120 TEFEWPKNMM PSSFAMKCRK HLKSRRLVSA KQLGVDRIVD FQFGSDEAAY HLIIELYDRG 130 140 150 160 170 180 NIVLTDYEYV ILNILRFRTD EADDVKFAVR ERYPLDHARA AEPLLTLERL TEIVASAPKG 190 200 210 220 230 240 ELLKRVLNPL LPYGPALIEH CLLENGFSGN VKVDEKLETK GYIIQKREIK PSLEADKPVE 250 260 270 280 290 300 DILTYEEFHP FLFSQHSQCP YIEFESFDKA VDEFYSKIEG QKIDLKALQQ EKQALKKLDN 310 320 330 340 350 360 VRKDHENRLE ALQQAQEIDK LKGELIEMNL QIVDRAIQVV RSALANQIDW TEIGLIVKEA 370 380 390 400 410 420 QAQGDPVASA IKELKLQTNH VTMLLRNPYL LSEEEDDDVD GDVNVEKNET EPPKGKKKKQ 430 440 450 460 470 480 KNKQLQKPQK NKPLLVDVDL SLSAYANAKK YYDHKRYAAK KTQKTVEAAE KAFKSAEKKT 490 500 510 520 530 540 KQTLKEVQTV TSIQKARKVY WFEKFLWFIS SENYLIIGGR DQQQNEIIVK RYLTPGDIYV 550 560 570 580 590 600 HADLHGATSC VIKNPTGEPI PPRTLTEAGT MALCYSAAWD ARVITSAWWV YHHQVSKTAP 610 620 630 640 650 660 TGEYLTTGSF MIRGKKNFLP PSYLMMGFSF LFKVDESCVW RHQGERKVRV QDEDMETLAS 670 680 690 700 710 720 CTSELISEEM EQLDGGDTSS DEDKEEHETP VEVELMTQVD QEDITLQSGR DELNEELIQE 730 740 750 760 770 780 ESSEDEGEYE EVRKDQDSVG EMKDEGEETL NYPDTTIDLS HLQPQRSIQK LASKEESSNS 790 800 810 820 830 840 SDSKSQSRRH LSAKERREMK KKKLPSDSGD LEALEGKDKE KESTVHIETH QNTSKNVAAV 850 860 870 880 890 900 QPMKRGQKSK MKKMKEKYKD QDEEDRELIM KLLGSAGSNK EEKGKKGKKG KTKDEPVKKQ 910 920 930 940 950 960 PQKPRGGQRV SDNIKKETPF LEVITHELQD FAVDDPHDDK EEQDLDQQGN EENLFDSLTG 970 980 990 1000 1010 1020 QPHPEDVLLF AIPICAPYTT MTNYKYKVKL TPGVQKKGKA AKTALNSFMH SKEATAREKD 1030 1040 1050 LFRSVKDTDL SRNIPGKVKV SAPNLLNVKR K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1041 (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1049 (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-518 (ISOFORM 1), VARIANT CYS-257. Tissue: Astrocyte, Brain, Embryo, Thymus and Uterus.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 418-1076 (ISOFORM 1). Tissue: Small intestine.
[3]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-438 AND 620-1076 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-432 (ISOFORM 4), VARIANT CYS-257. Tissue: Brain, Kidney and Placenta.
[5]	"Characterization of human colon cancer antigens recognized by autologous antibodies." Scanlan M.J., Chen Y.-T., Williamson B., Gure A.O., Stockert E., Gordan J.D., Tuereci O., Sahin U., Pfreundschuh M., Old L.J. Int. J. Cancer 76:652-658(1998) [PubMed: 9610721] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 712-1076. Tissue: Colon carcinoma.
[6]	"Drosophila caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells." Bi X., Jones T., Abbasi F., Lee H., Stultz B., Hursh D.A., Mortin M.A. Oncogene 24:8229-8239(2005) [PubMed: 16103875] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, MISCELLANEOUS.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-692; THR-703; SER-704; SER-705; SER-747 AND SER-748, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-417; SER-747 AND SER-748, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-417, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK000913 mRNA. No translation available. AK093783 mRNA. Translation: BAG52763.1. Different initiation. AK293236 mRNA. Translation: BAG56774.1. AK295010 mRNA. Translation: BAG58070.1. Sequence problems. AK304695 mRNA. Translation: BAG65465.1. BX640804 mRNA. Translation: CAE45886.1. BX640807 mRNA. Translation: CAE45889.1. BX648753 mRNA. No translation available. AL591767 Genomic DNA. No translation available. AL627171 Genomic DNA. No translation available. BC006001 mRNA. Translation: AAH06001.1. Sequence problems. BC020794 mRNA. Translation: AAH20794.2. Different initiation. BC056687 mRNA. Translation: AAH56687.1. Sequence problems. BC064364 mRNA. Translation: AAH64364.1. BC107764 mRNA. Translation: AAI07765.1. Different initiation. AF039687 mRNA. Translation: AAC18036.1. Frameshift.
IPI	IPI00301618. IPI00377155. IPI01013468. IPI01013837. IPI01016067.
RefSeq	NP_004704.2. NM_004713.3.
UniGene	Hs.655964.
3D structure databases
ProteinModelPortal	O60524.
ModBase	Search...
Protein-protein interaction databases
STRING	O60524.
PTM databases
PhosphoSite	O60524.
Proteomic databases
PRIDE	O60524.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000298310; ENSP00000298310; ENSG00000165525.
GeneID	9147.
KEGG	hsa:9147.
UCSC	uc001wwz.1. human. uc001wxc.1. human.
Organism-specific databases
CTD	9147.
GeneCards	GC14M050250.
H-InvDB	HIX0011634. HIX0037661.
HGNC	HGNC:10663. NEMF.
HPA	HPA004160.
MIM	608378. gene.
neXtProt	NX_O60524.
PharmGKB	PA35593.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG11105.
HOGENOM	HBG562845.
HOVERGEN	HBG079170.
InParanoid	O60524.
OMA	TTIQKAR.
OrthoDB	EOG4JDH63.
PhylomeDB	O60524.
Gene expression databases
ArrayExpress	O60524.
Bgee	O60524.
CleanEx	HS_SDCCAG1.
Genevestigator	O60524.
GermOnline	ENSG00000165525. Homo sapiens.
Family and domain databases
InterPro	IPR021846. DUF3441. IPR008532. DUF814. IPR008616. Fibro-bd_N. [Graphical view]
Pfam	PF11923. DUF3441. 1 hit. PF05670. DUF814. 1 hit. PF05833. FbpA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	34311.
SOURCE	Search...

Entry information

Entry name

NEMF_HUMAN

Accession

Primary (citable) accession number: O60524
Secondary accession number(s): A0JLQ3 , B3KSK1, B4DDL3, B4DHA9, B4E3F3, Q32Q66, Q8WW70, Q9NWG1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2003
Last sequence update:	November 24, 2009
Last modified:	January 25, 2012
This is version 92 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.