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Protein

Tudor domain-containing protein 6

Gene

TDRD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in spermiogenesis, chromatoid body formation and for proper precursor and mature miRNA expression.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180113-MONOMER.
ReactomeiR-HSA-5601884. PIWI-interacting RNA (piRNA) biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Tudor domain-containing protein 6
Alternative name(s):
Antigen NY-CO-45
Cancer/testis antigen 41.2
Short name:
CT41.2
Gene namesi
Name:TDRD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21339. TDRD6.

Subcellular locationi

  • Cytoplasm By similarity

  • Note: Present in chromatoid body (CB) of spermatids (mammalian counterpart of germplasm, pole plasm or polar granules in Drosophila germ cells), also named processing bodies (P-bodies) in somatic cells. Detected in the multilobular cytoplasmic CBs (also called intermitochondrial cementin) in pachytene spermatocytes and as a single perinuclear CB in haploid round spermatids. Colocalizes in CB with DDX4, PIWIL1, PIWIL2, TDRD1 and TDRD7 (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi221400.
OpenTargetsiENSG00000180113.
PharmGKBiPA134945900.

Polymorphism and mutation databases

BioMutaiTDRD6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001831671 – 2096Tudor domain-containing protein 6Add BLAST2096

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei293PhosphothreonineBy similarity1
Modified residuei1722PhosphoserineBy similarity1
Modified residuei2062PhosphoserineBy similarity1

Post-translational modificationi

Undergoes proteolytic cleavage near the C-terminal by an unknown protease during the transition from meiosis I to meiosis II in primary spermatocytes.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO60522.
PaxDbiO60522.
PeptideAtlasiO60522.
PRIDEiO60522.

PTM databases

iPTMnetiO60522.
PhosphoSitePlusiO60522.
SwissPalmiO60522.

Expressioni

Gene expression databases

BgeeiENSG00000180113.
CleanExiHS_TDRD6.
ExpressionAtlasiO60522. baseline and differential.
GenevisibleiO60522. HS.

Interactioni

Subunit structurei

Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex, at least composed of PIWIL1, PIWIL2 and TDRD6. Interacts with DDX4 and PIWIL1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi128720. 2 interactors.
STRINGi9606.ENSP00000346065.

Structurei

3D structure databases

ProteinModelPortaliO60522.
SMRiO60522.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 120Tudor 1PROSITE-ProRule annotationAdd BLAST56
Domaini310 – 369Tudor 2PROSITE-ProRule annotationAdd BLAST60
Domaini536 – 593Tudor 3PROSITE-ProRule annotationAdd BLAST58
Domaini816 – 875Tudor 4PROSITE-ProRule annotationAdd BLAST60
Domaini1033 – 1088Tudor 5PROSITE-ProRule annotationAdd BLAST56
Domaini1352 – 1411Tudor 6PROSITE-ProRule annotationAdd BLAST60
Domaini1567 – 1626Tudor 7PROSITE-ProRule annotationAdd BLAST60
Domaini2026 – 2084Tudor 8PROSITE-ProRule annotationAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi453 – 458Poly-Glu6

Sequence similaritiesi

Contains 8 Tudor domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2039. Eukaryota.
ENOG4110W7C. LUCA.
GeneTreeiENSGT00730000110295.
HOGENOMiHOG000154540.
HOVERGENiHBG059095.
InParanoidiO60522.
KOiK18405.
OMAiWTFYCQL.
OrthoDBiEOG091G007R.
PhylomeDBiO60522.

Family and domain databases

Gene3Di2.40.50.90. 1 hit.
InterProiIPR016071. Staphylococal_nuclease_OB-fold.
IPR002999. Tudor.
[Graphical view]
PfamiPF00567. TUDOR. 7 hits.
[Graphical view]
SMARTiSM00333. TUDOR. 8 hits.
[Graphical view]
PROSITEiPS50304. TUDOR. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60522-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCSTPGMPAP GASLALRVSF VDVHPDVIPV QLWGLVGERR GEYLRLSREI
60 70 80 90 100
QEAAATRGQW ALGSASASPG ELCLVQVGLL WHRCRVVSRQ AQESRVFLLD
110 120 130 140 150
EGRTITAGAG SLAPGRREFF NLPSEVLGCV LAGLVPAGCG AGSGEPPQHW
160 170 180 190 200
PADAVDFLSN LQGKEVHGCV LDVLLLHRLV LLEVPDVFQQ MRELGLARRV
210 220 230 240 250
PDSLFRSLLE RYLTAATASV GSGVPVLSRV PLKQKQPGLD YFYPQLQLGV
260 270 280 290 300
TEAVVITQVC HPHRIHCQLR SVSQEIHRLS ESMAQVYRGS TGTGDENSTS
310 320 330 340 350
ATWEEREESP DKPGSPCASC GLDGHWYRAL LLETFRPQRC AQVLHVDYGR
360 370 380 390 400
KELVSCSSLR YLLPEYFRMP VVTYPCALYG LWDGGRGWSR SQVGDLKTLI
410 420 430 440 450
LGKAVNAKIE FYCSFEHVYY VSLYGEDGIN LNRVFGVQSC CLADRVLQSQ
460 470 480 490 500
ATEEEEPETS QSQSPAEEVD EEISLPALRS IRLKMNAFYD AQVEFVKNPS
510 520 530 540 550
EFWIRLRKHN VTFSKLMRRM CGFYSSASKL DGVVLKPEPD DLCCVKWKEN
560 570 580 590 600
GYYRAIVTKL DDKSVDVFLV DRGNSENVDW YDVRMLLPQF RQLPILAVKC
610 620 630 640 650
TLADIWPLGK TWSQEAVSFF KKTVLHKELV IHILDKQDHQ YVIEILDESR
660 670 680 690 700
TGEENISKVI AQAGYAKYQE FETKENILVN AHSPGHVSNH FTTESNKIPF
710 720 730 740 750
AKTGEGEQKA KRENKTTSVS KALSDTTVVT NGSTELVVQE KVKRASVYFP
760 770 780 790 800
LMQNCLEIKP GSSSKGELEV GSTVEVRVSY VENPGYFWCQ LTRNIQGLKT
810 820 830 840 850
LMSDIQYYCK NTAAPHQRNT LACLAKRTVN RQWSRALISG IQSVEHVNVT
860 870 880 890 900
FVDYGDREMV SVKNIYSISE EFLKVKAQAF RCSLYNLIQP VGQNPFVWDV
910 920 930 940 950
KAIQAFNEFI DNAWQKNLEL KCTIFALASI NEELFNIVDL LTPFQSACHF
960 970 980 990 1000
LVEKRLARPV KLQKPLESSV QLHSYFYSTH DMKIGSEELV YITHIDDPWT
1010 1020 1030 1040 1050
FYCQLARNAN ILEQLSCSIT QLSKVLLNLK TSPLNPGTLC LAKYTDGNWY
1060 1070 1080 1090 1100
RGIVIEKEPK KVFFVDFGNI YVVTSDDLLP IPSDAYDVLL LPMQAVRCSL
1110 1120 1130 1140 1150
SDIPDHIPEE VVVWFQETIL DKSLKALVVA KDPDGTLIIE LYGDNIQISA
1160 1170 1180 1190 1200
SINKKLGLLS YKDRIRKKES EVLCSTTETL EEKNENMKLP CTEYLSKSVG
1210 1220 1230 1240 1250
YKLPNKEILE ESYKPQINSS YKELKLLQSL TKTNLVTQYQ DSVGNKNSQV
1260 1270 1280 1290 1300
FPLTTEKKEE ISAETPLKTA RVEATLSERK IGDSCDKDLP LKFCEFPQKT
1310 1320 1330 1340 1350
IMPGFKTTVY VSHINDLSDF YVQLIEDEAE ISHLSERLNS VKTRPEYYVG
1360 1370 1380 1390 1400
PPLQRGDMIC AVFPEDNLWY RAVIKEQQPN DLLSVQFIDY GNVSVVHTNK
1410 1420 1430 1440 1450
IGRLDLVNAI LPGLCIHCSL QGFEVPDNKN SKKMMHYFSQ RTSEAAIRCE
1460 1470 1480 1490 1500
FVKFQDRWEV ILADEHGIIA DDMISRYALS EKSQVELSTQ VIKSASSKSV
1510 1520 1530 1540 1550
NKSDIDTSVF LNWYNPEKKM IRAYATVIDG PEYFWCQFAD TEKLQCLEVE
1560 1570 1580 1590 1600
VQTAGEQVAD RRNCIPCPYI GDPCIVRYRE DGHYYRALIT NICEDYLVSV
1610 1620 1630 1640 1650
RLVDFGNIED CVDPKALWAI PSELLSVPMQ AFPCCLSGFN ISEGLCSQEG
1660 1670 1680 1690 1700
NDYFYEIITE DVLEITILEI RRDVCDIPLA IVDLKSKGKS INEKMEKYSK
1710 1720 1730 1740 1750
TGIKSALPYE NIDSEIKQTL GSYNLDVGLK KLSNKAVQNK IYMEQQTDEL
1760 1770 1780 1790 1800
AEITEKDVNI IGTKPSNFRD PKTDNICEGF ENPCKDKIDT EELEGELECH
1810 1820 1830 1840 1850
LVDKAEFDDK YLITGFNTLL PHANETKEIL ELNSLEVPLS PDDESKEFLE
1860 1870 1880 1890 1900
LESIELQNSL VVDEEKGELS PVPPNVPLSQ ECVTKGAMEL FTLQLPLSCE
1910 1920 1930 1940 1950
AEKQPELELP TAQLPLDDKM DPLSLGVSQK AQESMCTEDM RKSSCVESFD
1960 1970 1980 1990 2000
DQRRMSLHLH GADCDPKTQN EMNICEEEFV EYKNRDAISA LMPLFSEEES
2010 2020 2030 2040 2050
SDGSKHNNGL PDHISAQLQN TYTLKAFTVG SKCVVWSSLR NTWSKCEILE
2060 2070 2080 2090
TAEEGTRVLN LSNGMEEIVN PENVWNGIPK LDKSPPEKRG LEVMEI
Length:2,096
Mass (Da):236,517
Last modified:November 28, 2006 - v2
Checksum:i19FED65D6FE68E44
GO
Isoform 2 (identifier: O60522-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2058-2087: Missing.

Note: No experimental confirmation available.
Show »
Length:2,066
Mass (Da):233,202
Checksum:iF2ECB829FF541756
GO

Sequence cautioni

The sequence AAC18034 differs from that shown. Reason: Frameshift at position 1994.Curated
The sequence CAI45997 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1273E → K in AAC18034 (PubMed:9610721).Curated1
Sequence conflicti1455Q → R in CAI45997 (PubMed:17974005).Curated1
Sequence conflicti1955M → V in CAI45997 (PubMed:17974005).Curated1
Sequence conflicti2016A → D in AAC18034 (PubMed:9610721).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029050192R → Q.Corresponds to variant rs7750596dbSNPEnsembl.1
Natural variantiVAR_029051398T → A.Corresponds to variant rs3799277dbSNPEnsembl.1
Natural variantiVAR_052423795I → M.Corresponds to variant rs9463234dbSNPEnsembl.1
Natural variantiVAR_0290521014Q → E.1 PublicationCorresponds to variant rs9381472dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0448012058 – 2087Missing in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591242 Genomic DNA. Translation: CAH73905.1.
AK125838 mRNA. Translation: BAG54254.1.
AK131455 mRNA. No translation available.
BX648686 mRNA. Translation: CAI45997.1. Different initiation.
AF039442 mRNA. Translation: AAC18034.1. Frameshift.
CCDSiCCDS34470.1. [O60522-1]
CCDS55017.1. [O60522-2]
RefSeqiNP_001010870.1. NM_001010870.2. [O60522-1]
NP_001161831.1. NM_001168359.1. [O60522-2]
UniGeneiHs.656983.

Genome annotation databases

EnsembliENST00000316081; ENSP00000346065; ENSG00000180113. [O60522-1]
ENST00000544460; ENSP00000443299; ENSG00000180113. [O60522-2]
GeneIDi221400.
KEGGihsa:221400.
UCSCiuc003oyj.4. human. [O60522-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591242 Genomic DNA. Translation: CAH73905.1.
AK125838 mRNA. Translation: BAG54254.1.
AK131455 mRNA. No translation available.
BX648686 mRNA. Translation: CAI45997.1. Different initiation.
AF039442 mRNA. Translation: AAC18034.1. Frameshift.
CCDSiCCDS34470.1. [O60522-1]
CCDS55017.1. [O60522-2]
RefSeqiNP_001010870.1. NM_001010870.2. [O60522-1]
NP_001161831.1. NM_001168359.1. [O60522-2]
UniGeneiHs.656983.

3D structure databases

ProteinModelPortaliO60522.
SMRiO60522.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128720. 2 interactors.
STRINGi9606.ENSP00000346065.

PTM databases

iPTMnetiO60522.
PhosphoSitePlusiO60522.
SwissPalmiO60522.

Polymorphism and mutation databases

BioMutaiTDRD6.

Proteomic databases

MaxQBiO60522.
PaxDbiO60522.
PeptideAtlasiO60522.
PRIDEiO60522.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316081; ENSP00000346065; ENSG00000180113. [O60522-1]
ENST00000544460; ENSP00000443299; ENSG00000180113. [O60522-2]
GeneIDi221400.
KEGGihsa:221400.
UCSCiuc003oyj.4. human. [O60522-1]

Organism-specific databases

CTDi221400.
DisGeNETi221400.
GeneCardsiTDRD6.
H-InvDBHIX0025021.
HGNCiHGNC:21339. TDRD6.
MIMi611200. gene.
neXtProtiNX_O60522.
OpenTargetsiENSG00000180113.
PharmGKBiPA134945900.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2039. Eukaryota.
ENOG4110W7C. LUCA.
GeneTreeiENSGT00730000110295.
HOGENOMiHOG000154540.
HOVERGENiHBG059095.
InParanoidiO60522.
KOiK18405.
OMAiWTFYCQL.
OrthoDBiEOG091G007R.
PhylomeDBiO60522.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180113-MONOMER.
ReactomeiR-HSA-5601884. PIWI-interacting RNA (piRNA) biogenesis.

Miscellaneous databases

GenomeRNAii221400.
PROiO60522.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180113.
CleanExiHS_TDRD6.
ExpressionAtlasiO60522. baseline and differential.
GenevisibleiO60522. HS.

Family and domain databases

Gene3Di2.40.50.90. 1 hit.
InterProiIPR016071. Staphylococal_nuclease_OB-fold.
IPR002999. Tudor.
[Graphical view]
PfamiPF00567. TUDOR. 7 hits.
[Graphical view]
SMARTiSM00333. TUDOR. 8 hits.
[Graphical view]
PROSITEiPS50304. TUDOR. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTDRD6_HUMAN
AccessioniPrimary (citable) accession number: O60522
Secondary accession number(s): B3KWU2
, F5H5M3, Q5HYB1, Q5VTS4, Q6ZMX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: November 28, 2006
Last modified: November 30, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.