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O60519

- CRBL2_HUMAN

UniProt

O60519 - CRBL2_HUMAN

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Protein

cAMP-responsive element-binding protein-like 2

Gene

CREBL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor.1 Publication

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell differentiation Source: UniProtKB-KW
  3. positive regulation of fat cell differentiation Source: UniProtKB
  4. positive regulation of glucose import Source: UniProtKB
  5. positive regulation of lipid biosynthetic process Source: UniProtKB
  6. positive regulation of peptidyl-serine phosphorylation Source: UniProtKB
  7. positive regulation of transcription, DNA-templated Source: UniProtKB
  8. protein stabilization Source: UniProtKB
  9. signal transduction Source: ProtInc
  10. transcription, DNA-templated Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Cell cycle, Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-responsive element-binding protein-like 2
Gene namesi
Name:CREBL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:2350. CREBL2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

PharmGKBiPA26868.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 120120cAMP-responsive element-binding protein-like 2PRO_0000318192Add
BLAST

Post-translational modificationi

Phosphorylated by AMPK.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO60519.
PRIDEiO60519.

Expressioni

Gene expression databases

BgeeiO60519.
CleanExiHS_CREBL2.
GenevestigatoriO60519.

Organism-specific databases

HPAiHPA043738.

Interactioni

Subunit structurei

Interacts with CREB1; regulates CREB1 phosphorylation, stability and transcriptional activity.By similarity

Protein-protein interaction databases

BioGridi107779. 1 interaction.
IntActiO60519. 1 interaction.
STRINGi9606.ENSP00000228865.

Structurei

3D structure databases

ProteinModelPortaliO60519.
SMRiO60519. Positions 28-74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 8664bZIPAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni29 – 6032Basic motifBy similarityAdd
BLAST
Regioni62 – 698Leucine-zipperBy similarity

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated

Phylogenomic databases

eggNOGiNOG85470.
GeneTreeiENSGT00390000005388.
HOGENOMiHOG000111966.
HOVERGENiHBG107761.
InParanoidiO60519.
OMAiQQNSGRH.
OrthoDBiEOG7TQV3F.
PhylomeDBiO60519.
TreeFamiTF323305.

Family and domain databases

InterProiIPR004827. bZIP.
[Graphical view]
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60519-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDDSKVVGGK VKKPGKRGRK PAKIDLKAKL ERSRQSAREC RARKKLRYQY
60 70 80 90 100
LEELVSSRER AICALREELE MYKQWCMAMD QGKIPSEIKA LLTGEEQNKS
110 120
QQNSSRHTKA GKTDANSNSW
Length:120
Mass (Da):13,784
Last modified:August 1, 1998 - v1
Checksum:iE191B2D239EDA17B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039081 mRNA. Translation: AAC32314.1.
AB451461 mRNA. Translation: BAG70275.1.
CR542250 mRNA. Translation: CAG47046.1.
CH471094 Genomic DNA. Translation: EAW96269.1.
BC104873 mRNA. Translation: AAI04874.1.
BC106052 mRNA. Translation: AAI06053.1.
BC112157 mRNA. Translation: AAI12158.1.
CCDSiCCDS8651.1.
RefSeqiNP_001301.1. NM_001310.3.
UniGeneiHs.591156.

Genome annotation databases

EnsembliENST00000228865; ENSP00000228865; ENSG00000111269.
GeneIDi1389.
KEGGihsa:1389.
UCSCiuc001rap.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039081 mRNA. Translation: AAC32314.1 .
AB451461 mRNA. Translation: BAG70275.1 .
CR542250 mRNA. Translation: CAG47046.1 .
CH471094 Genomic DNA. Translation: EAW96269.1 .
BC104873 mRNA. Translation: AAI04874.1 .
BC106052 mRNA. Translation: AAI06053.1 .
BC112157 mRNA. Translation: AAI12158.1 .
CCDSi CCDS8651.1.
RefSeqi NP_001301.1. NM_001310.3.
UniGenei Hs.591156.

3D structure databases

ProteinModelPortali O60519.
SMRi O60519. Positions 28-74.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107779. 1 interaction.
IntActi O60519. 1 interaction.
STRINGi 9606.ENSP00000228865.

Proteomic databases

PaxDbi O60519.
PRIDEi O60519.

Protocols and materials databases

DNASUi 1389.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000228865 ; ENSP00000228865 ; ENSG00000111269 .
GeneIDi 1389.
KEGGi hsa:1389.
UCSCi uc001rap.1. human.

Organism-specific databases

CTDi 1389.
GeneCardsi GC12P012764.
HGNCi HGNC:2350. CREBL2.
HPAi HPA043738.
MIMi 603476. gene.
neXtProti NX_O60519.
PharmGKBi PA26868.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG85470.
GeneTreei ENSGT00390000005388.
HOGENOMi HOG000111966.
HOVERGENi HBG107761.
InParanoidi O60519.
OMAi QQNSGRH.
OrthoDBi EOG7TQV3F.
PhylomeDBi O60519.
TreeFami TF323305.

Miscellaneous databases

ChiTaRSi CREBL2. human.
GenomeRNAii 1389.
NextBioi 5645.
PROi O60519.
SOURCEi Search...

Gene expression databases

Bgeei O60519.
CleanExi HS_CREBL2.
Genevestigatori O60519.

Family and domain databases

InterProi IPR004827. bZIP.
[Graphical view ]
Pfami PF07716. bZIP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "CREBL2, a novel transcript from the chromosome 12 region flanked by ETV6 and CDKN1B."
    Hoornaert I., Marynen P., Baens M.
    Genomics 51:154-157(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Tissue: Bone marrow.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
    Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.
    , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N.
    Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Skin.
  7. "AMP-activated protein kinase phosphorylates transcription factors of the CREB family."
    Thomson D.M., Herway S.T., Fillmore N., Kim H., Brown J.D., Barrow J.R., Winder W.W.
    J. Appl. Physiol. 104:429-438(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY AMPK.

Entry informationi

Entry nameiCRBL2_HUMAN
AccessioniPrimary (citable) accession number: O60519
Secondary accession number(s): B5BUM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 1, 1998
Last modified: November 26, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3