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O60519

- CRBL2_HUMAN

UniProt

O60519 - CRBL2_HUMAN

Protein

cAMP-responsive element-binding protein-like 2

Gene

CREBL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor.1 Publication

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell differentiation Source: UniProtKB-KW
    3. positive regulation of fat cell differentiation Source: UniProtKB
    4. positive regulation of glucose import Source: UniProtKB
    5. positive regulation of lipid biosynthetic process Source: UniProtKB
    6. positive regulation of peptidyl-serine phosphorylation Source: UniProtKB
    7. positive regulation of transcription, DNA-templated Source: UniProtKB
    8. protein stabilization Source: UniProtKB
    9. signal transduction Source: ProtInc
    10. transcription, DNA-templated Source: ProtInc

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Cell cycle, Differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    cAMP-responsive element-binding protein-like 2
    Gene namesi
    Name:CREBL2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:2350. CREBL2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    Organism-specific databases

    PharmGKBiPA26868.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 120120cAMP-responsive element-binding protein-like 2PRO_0000318192Add
    BLAST

    Post-translational modificationi

    Phosphorylated by AMPK.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiO60519.
    PRIDEiO60519.

    Expressioni

    Gene expression databases

    BgeeiO60519.
    CleanExiHS_CREBL2.
    GenevestigatoriO60519.

    Organism-specific databases

    HPAiHPA043738.

    Interactioni

    Subunit structurei

    Interacts with CREB1; regulates CREB1 phosphorylation, stability and transcriptional activity.By similarity

    Protein-protein interaction databases

    BioGridi107779. 1 interaction.
    IntActiO60519. 1 interaction.
    STRINGi9606.ENSP00000228865.

    Structurei

    3D structure databases

    ProteinModelPortaliO60519.
    SMRiO60519. Positions 28-74.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 8664bZIPAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni29 – 6032Basic motifBy similarityAdd
    BLAST
    Regioni62 – 698Leucine-zipperBy similarity

    Sequence similaritiesi

    Belongs to the bZIP family. ATF subfamily.Curated

    Phylogenomic databases

    eggNOGiNOG85470.
    HOGENOMiHOG000111966.
    HOVERGENiHBG107761.
    InParanoidiO60519.
    OMAiQQNSGRH.
    OrthoDBiEOG7TQV3F.
    PhylomeDBiO60519.
    TreeFamiTF323305.

    Family and domain databases

    InterProiIPR004827. bZIP.
    [Graphical view]
    PfamiPF07716. bZIP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O60519-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDDSKVVGGK VKKPGKRGRK PAKIDLKAKL ERSRQSAREC RARKKLRYQY    50
    LEELVSSRER AICALREELE MYKQWCMAMD QGKIPSEIKA LLTGEEQNKS 100
    QQNSSRHTKA GKTDANSNSW 120
    Length:120
    Mass (Da):13,784
    Last modified:August 1, 1998 - v1
    Checksum:iE191B2D239EDA17B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF039081 mRNA. Translation: AAC32314.1.
    AB451461 mRNA. Translation: BAG70275.1.
    CR542250 mRNA. Translation: CAG47046.1.
    CH471094 Genomic DNA. Translation: EAW96269.1.
    BC104873 mRNA. Translation: AAI04874.1.
    BC106052 mRNA. Translation: AAI06053.1.
    BC112157 mRNA. Translation: AAI12158.1.
    CCDSiCCDS8651.1.
    RefSeqiNP_001301.1. NM_001310.3.
    UniGeneiHs.591156.

    Genome annotation databases

    EnsembliENST00000228865; ENSP00000228865; ENSG00000111269.
    GeneIDi1389.
    KEGGihsa:1389.
    UCSCiuc001rap.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF039081 mRNA. Translation: AAC32314.1 .
    AB451461 mRNA. Translation: BAG70275.1 .
    CR542250 mRNA. Translation: CAG47046.1 .
    CH471094 Genomic DNA. Translation: EAW96269.1 .
    BC104873 mRNA. Translation: AAI04874.1 .
    BC106052 mRNA. Translation: AAI06053.1 .
    BC112157 mRNA. Translation: AAI12158.1 .
    CCDSi CCDS8651.1.
    RefSeqi NP_001301.1. NM_001310.3.
    UniGenei Hs.591156.

    3D structure databases

    ProteinModelPortali O60519.
    SMRi O60519. Positions 28-74.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107779. 1 interaction.
    IntActi O60519. 1 interaction.
    STRINGi 9606.ENSP00000228865.

    Proteomic databases

    PaxDbi O60519.
    PRIDEi O60519.

    Protocols and materials databases

    DNASUi 1389.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000228865 ; ENSP00000228865 ; ENSG00000111269 .
    GeneIDi 1389.
    KEGGi hsa:1389.
    UCSCi uc001rap.1. human.

    Organism-specific databases

    CTDi 1389.
    GeneCardsi GC12P012764.
    HGNCi HGNC:2350. CREBL2.
    HPAi HPA043738.
    MIMi 603476. gene.
    neXtProti NX_O60519.
    PharmGKBi PA26868.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG85470.
    HOGENOMi HOG000111966.
    HOVERGENi HBG107761.
    InParanoidi O60519.
    OMAi QQNSGRH.
    OrthoDBi EOG7TQV3F.
    PhylomeDBi O60519.
    TreeFami TF323305.

    Miscellaneous databases

    GenomeRNAii 1389.
    NextBioi 5645.
    PROi O60519.
    SOURCEi Search...

    Gene expression databases

    Bgeei O60519.
    CleanExi HS_CREBL2.
    Genevestigatori O60519.

    Family and domain databases

    InterProi IPR004827. bZIP.
    [Graphical view ]
    Pfami PF07716. bZIP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CREBL2, a novel transcript from the chromosome 12 region flanked by ETV6 and CDKN1B."
      Hoornaert I., Marynen P., Baens M.
      Genomics 51:154-157(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Tissue: Bone marrow.
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
      Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.
      , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N.
      Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Skin.
    7. "AMP-activated protein kinase phosphorylates transcription factors of the CREB family."
      Thomson D.M., Herway S.T., Fillmore N., Kim H., Brown J.D., Barrow J.R., Winder W.W.
      J. Appl. Physiol. 104:429-438(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION BY AMPK.

    Entry informationi

    Entry nameiCRBL2_HUMAN
    AccessioniPrimary (citable) accession number: O60519
    Secondary accession number(s): B5BUM5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3