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Protein

cAMP-responsive element-binding protein-like 2

Gene

CREBL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor.1 Publication

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: ProtInc
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processCell cycle, Differentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-responsive element-binding protein-like 2
Gene namesi
Name:CREBL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111269.2
HGNCiHGNC:2350 CREBL2
MIMi603476 gene
neXtProtiNX_O60519

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

OpenTargetsiENSG00000111269
PharmGKBiPA26868

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003181921 – 120cAMP-responsive element-binding protein-like 2Add BLAST120

Post-translational modificationi

Phosphorylated by AMPK.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO60519
PeptideAtlasiO60519
PRIDEiO60519

Expressioni

Gene expression databases

BgeeiENSG00000111269
CleanExiHS_CREBL2
GenevisibleiO60519 HS

Organism-specific databases

HPAiHPA043738

Interactioni

Subunit structurei

Interacts with CREB1; regulates CREB1 phosphorylation, stability and transcriptional activity.By similarity

Protein-protein interaction databases

BioGridi1077792 interactors.
IntActiO60519 4 interactors.
STRINGi9606.ENSP00000228865

Structurei

3D structure databases

ProteinModelPortaliO60519
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 86bZIPAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 60Basic motifBy similarityAdd BLAST32
Regioni62 – 69Leucine-zipperBy similarity8

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated

Phylogenomic databases

eggNOGiENOG410J0Q3 Eukaryota
ENOG4111T4Y LUCA
GeneTreeiENSGT00390000005388
HOGENOMiHOG000111966
HOVERGENiHBG107761
InParanoidiO60519
OMAiEANNNSW
OrthoDBiEOG091G15EI
PhylomeDBiO60519
TreeFamiTF323305

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
PfamiView protein in Pfam
PF07716 bZIP_2, 1 hit

Sequencei

Sequence statusi: Complete.

O60519-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDSKVVGGK VKKPGKRGRK PAKIDLKAKL ERSRQSAREC RARKKLRYQY
60 70 80 90 100
LEELVSSRER AICALREELE MYKQWCMAMD QGKIPSEIKA LLTGEEQNKS
110 120
QQNSSRHTKA GKTDANSNSW
Length:120
Mass (Da):13,784
Last modified:August 1, 1998 - v1
Checksum:iE191B2D239EDA17B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039081 mRNA Translation: AAC32314.1
AB451461 mRNA Translation: BAG70275.1
CR542250 mRNA Translation: CAG47046.1
CH471094 Genomic DNA Translation: EAW96269.1
BC104873 mRNA Translation: AAI04874.1
BC106052 mRNA Translation: AAI06053.1
BC112157 mRNA Translation: AAI12158.1
CCDSiCCDS8651.1
RefSeqiNP_001301.1, NM_001310.3
UniGeneiHs.591156

Genome annotation databases

EnsembliENST00000228865; ENSP00000228865; ENSG00000111269
GeneIDi1389
KEGGihsa:1389
UCSCiuc001rap.3 human

Similar proteinsi

Entry informationi

Entry nameiCRBL2_HUMAN
AccessioniPrimary (citable) accession number: O60519
Secondary accession number(s): B5BUM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 1, 1998
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome