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Protein

Ran-binding protein 6

Gene

RANBP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function in nuclear protein import as nuclear transport receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Ran-binding protein 6
Short name:
RanBP6
Gene namesi
Name:RANBP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:9851. RANBP6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34212.

Polymorphism and mutation databases

BioMutaiRANBP6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 11051104Ran-binding protein 6PRO_0000120779Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei835 – 8351PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO60518.
MaxQBiO60518.
PaxDbiO60518.
PeptideAtlasiO60518.
PRIDEiO60518.

PTM databases

iPTMnetiO60518.
PhosphoSiteiO60518.

Expressioni

Gene expression databases

BgeeiENSG00000137040.
CleanExiHS_RANBP6.
ExpressionAtlasiO60518. baseline and differential.
GenevisibleiO60518. HS.

Organism-specific databases

HPAiHPA043748.
HPA052684.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Q763532EBI-1055771,EBI-6248077From a different organism.

Protein-protein interaction databases

BioGridi117924. 62 interactions.
IntActiO60518. 5 interactions.
MINTiMINT-1196413.
STRINGi9606.ENSP00000259569.

Structurei

3D structure databases

ProteinModelPortaliO60518.
SMRiO60518. Positions 177-615.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati219 – 25739HEAT 1Add
BLAST
Repeati361 – 39939HEAT 2Add
BLAST
Repeati402 – 44039HEAT 3Add
BLAST
Repeati444 – 48340HEAT 4Add
BLAST
Repeati866 – 90540HEAT 5Add
BLAST
Repeati908 – 94639HEAT 6Add
BLAST
Repeati949 – 98739HEAT 7Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni333 – 38351Ran-GTP bindingBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili806 – 84237Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi202 – 2076Poly-Ala

Sequence similaritiesi

Belongs to the importin beta family.Curated
Contains 7 HEAT repeats.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG2171. Eukaryota.
ENOG410XQAJ. LUCA.
GeneTreeiENSGT00550000074773.
HOGENOMiHOG000209725.
HOVERGENiHBG006156.
InParanoidiO60518.
OMAiFGTQERH.
OrthoDBiEOG091G011X.
PhylomeDBiO60518.
TreeFamiTF300344.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
[Graphical view]
PfamiPF02985. HEAT. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60518-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATASAGVP ATVSEKQEFY QLLKNLINPS CMVRRQAEEI YENIPGLCKT
60 70 80 90 100
TFLLDAVRNR RAGYEVRQMA AALLRRLLSS GFEEVYPNLP ADVQRDVKIE
110 120 130 140 150
LILAVKLETH ASMRKKLCDI FAVLARNLID EDGTNHWPEG LKFLIDSIYS
160 170 180 190 200
KNVVLWEVAL HVFWHFPGIF GTQERHDLDI IKRLLDQCIQ DQEHPAIRTL
210 220 230 240 250
SARAAAAFVL ANENNIALFK DFADLLPGIL QAVNDSCYQD DDSVLESLVE
260 270 280 290 300
IADTVPKYLG PYLEDTLQLS LKLCGDSRLS NLQRQLALEV IVTLSETATP
310 320 330 340 350
MLKKHTNIIA QAVPHILAMM VDLQDDEDWV NADEMEEDDF DSNAVAAESA
360 370 380 390 400
LDRLACGLGG KVVLPMTKEH IMQMLQSPDW KYRHAGLMAL SAIGEGCHQQ
410 420 430 440 450
MESILDETVN SVLLFLQDPH PRVRAAACTT LGQMATDFAP NFQKKFHETV
460 470 480 490 500
IAALLRTMEN QGNQRVQSHA ASALIIFIED CPKSLLVLYV DSMVKNLHSV
510 520 530 540 550
LVIKLQELIR NGTKLALEQL VTTIASVADT IEEKFVPYYD IFMPSLKHIV
560 570 580 590 600
ELAVQKELKL LRGKTIECIS HIGLAVGKEK FMQDASNVMQ LLLKTQSDLN
610 620 630 640 650
NMEDDDPQTS YMVSAWARMC KILGKDFQQY LPLVIEPLIK TASAKPDVAL
660 670 680 690 700
LDTQDVENMS DDDGWQFVNL GDQQSFGIKT SGLEAKATAC QMLVYYAKEL
710 720 730 740 750
REGFVEYTEQ VVKLMVPLLK FYFHDNVRVA AAESMPFLLE CARIRGPEYL
760 770 780 790 800
AQMWQFICDP LIKAIGTEPD TDVLSEIMNS FAKSIEVMGD GCLNDEHLEE
810 820 830 840 850
LGGILKAKLE GHFKNQELRQ VKRQEENYDQ QVEMSLQDED ECDVYILTKV
860 870 880 890 900
SDILHSLFST YKEKILPWFE QLLPLIVNLI CSSRPWPDRQ WGLCIFDDII
910 920 930 940 950
EHCSPTSFKY VEYFRWPMLL NMRDNNPEVR QAAAYGLGVM AQFGGDDYRS
960 970 980 990 1000
LCSEAVPLLV KVIKCANSKT KKNVIATENC ISAIGKILKF KPNCVNVDEV
1010 1020 1030 1040 1050
LPHWLSWLPL HEDKEEAIQT LSFLCDLIES NHPVVIGPNN SNLPKIISII
1060 1070 1080 1090 1100
AEGKINETIN YEDPCAKRLA NVVRQVQTSE DLWLECVSQL DDEQQEALQE

LLNFA
Length:1,105
Mass (Da):124,714
Last modified:March 7, 2006 - v2
Checksum:i9434C69D548DF150
GO

Sequence cautioni

The sequence CAD97647 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21A → P in AAC14260 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039023 mRNA. Translation: AAC14260.1.
BX537405 mRNA. Translation: CAD97647.1. Different initiation.
AL162384 Genomic DNA. Translation: CAI12713.1.
BC012805 mRNA. Translation: AAH12805.2.
BC098406 mRNA. Translation: AAH98406.1.
CCDSiCCDS6467.1.
RefSeqiNP_001230131.1. NM_001243202.1.
NP_001230132.1. NM_001243203.1.
NP_036548.1. NM_012416.3.
UniGeneiHs.167496.
Hs.732683.

Genome annotation databases

EnsembliENST00000259569; ENSP00000259569; ENSG00000137040.
GeneIDi26953.
KEGGihsa:26953.
UCSCiuc003zjr.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039023 mRNA. Translation: AAC14260.1.
BX537405 mRNA. Translation: CAD97647.1. Different initiation.
AL162384 Genomic DNA. Translation: CAI12713.1.
BC012805 mRNA. Translation: AAH12805.2.
BC098406 mRNA. Translation: AAH98406.1.
CCDSiCCDS6467.1.
RefSeqiNP_001230131.1. NM_001243202.1.
NP_001230132.1. NM_001243203.1.
NP_036548.1. NM_012416.3.
UniGeneiHs.167496.
Hs.732683.

3D structure databases

ProteinModelPortaliO60518.
SMRiO60518. Positions 177-615.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117924. 62 interactions.
IntActiO60518. 5 interactions.
MINTiMINT-1196413.
STRINGi9606.ENSP00000259569.

PTM databases

iPTMnetiO60518.
PhosphoSiteiO60518.

Polymorphism and mutation databases

BioMutaiRANBP6.

Proteomic databases

EPDiO60518.
MaxQBiO60518.
PaxDbiO60518.
PeptideAtlasiO60518.
PRIDEiO60518.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259569; ENSP00000259569; ENSG00000137040.
GeneIDi26953.
KEGGihsa:26953.
UCSCiuc003zjr.4. human.

Organism-specific databases

CTDi26953.
GeneCardsiRANBP6.
H-InvDBHIX0007906.
HGNCiHGNC:9851. RANBP6.
HPAiHPA043748.
HPA052684.
neXtProtiNX_O60518.
PharmGKBiPA34212.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2171. Eukaryota.
ENOG410XQAJ. LUCA.
GeneTreeiENSGT00550000074773.
HOGENOMiHOG000209725.
HOVERGENiHBG006156.
InParanoidiO60518.
OMAiFGTQERH.
OrthoDBiEOG091G011X.
PhylomeDBiO60518.
TreeFamiTF300344.

Miscellaneous databases

ChiTaRSiRANBP6. human.
GenomeRNAii26953.
PROiO60518.

Gene expression databases

BgeeiENSG00000137040.
CleanExiHS_RANBP6.
ExpressionAtlasiO60518. baseline and differential.
GenevisibleiO60518. HS.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
[Graphical view]
PfamiPF02985. HEAT. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiRNBP6_HUMAN
AccessioniPrimary (citable) accession number: O60518
Secondary accession number(s): Q5T7X4, Q7Z3V2, Q96E78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 7, 2006
Last modified: September 7, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.