O60516 (4EBP3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Eukaryotic translation initiation factor 4E-binding protein 3
Short name=4E-BP3
Short name=eIF4E-binding protein 3

Gene names

Name:

EIF4EBP3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	100 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulates eIF4E activity by preventing its assembly into the eIF4F complex.
Subunit structure	EIF4EBP3 interacts with EIF4E. Ref.1
Tissue specificity	Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus. Ref.1
Post-translational modification	Phosphorylated.
Sequence similarities	Belongs to the eIF4E-binding protein family.

Ontologies

Keywords
Biological process	Translation regulation
Molecular function	Protein synthesis inhibitor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of translational initiation Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	eukaryotic translation initiation factor 4F complex Non-traceable author statement Ref.1. Source: UniProtKB
Molecular_function	translation repressor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
EIF4E	P06730	2	EBI-746950,EBI-73440
Eif4e2	Q80ZJ3	2	EBI-746950,EBI-934970	From a different organism.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 100	100	Eukaryotic translation initiation factor 4E-binding protein 3		PRO_0000190518
Experimental info
	Mutagenesis	40	1	Y → A: Loss of interaction with EIF4E. Ref.1
	Mutagenesis	45	1	L → A: Loss of interaction with EIF4E. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O60516 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: FD29A7F3829E546E	FASTA	100	10,873
	10 20 30 40 50 60 MSTSTSCPIP GGRDQLPDCY STTPGGTLYA TTPGGTRIIY DRKFLLECKN SPIARTPPCC 70 80 90 100 LPQIPGVTTP PTAPLSKLEE LKEQETEEEI PDDAQFEMDI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family." Poulin F., Gingras A.-C., Olsen H., Chevalier S., Sonenberg N. J. Biol. Chem. 273:14002-14007(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH EIF4E, MUTAGENESIS OF TYR-40 AND LEU-45, TISSUE SPECIFICITY.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF038869 mRNA. Translation: AAC39761.1. BC010881 mRNA. Translation: AAH10881.1. BC069293 mRNA. Translation: AAH69293.1. BC073751 mRNA. Translation: AAH73751.1.
IPI	IPI00021476.
RefSeq	NP_003723.1. NM_003732.2.
UniGene	Hs.594084.
3D structure databases
ProteinModelPortal	O60516.
ModBase	Search...
Protein-protein interaction databases
IntAct	O60516. 3 interactions.
STRING	9606.ENSP00000308472.
PTM databases
PhosphoSite	O60516.
Proteomic databases
PaxDb	O60516.
PRIDE	O60516.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000310331; ENSP00000308472; ENSG00000243056.
GeneID	8637.
KEGG	hsa:8637.
UCSC	uc003lfy.1. human.
Organism-specific databases
CTD	8637.
GeneCards	GC05P139928.
HGNC	HGNC:3290. EIF4EBP3.
HPA	HPA045537.
MIM	603483. gene.
neXtProt	NX_O60516.
PharmGKB	PA27718.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG78084.
HOGENOM	HOG000231190.
HOVERGEN	HBG050425.
OMA	NQFEMDI.
OrthoDB	EOG47SSG8.
Gene expression databases
Bgee	O60516.
Genevestigator	O60516.
GermOnline	ENSG00000131503. Homo sapiens.
Family and domain databases
InterPro	IPR008606. EIF4EBP. [Graphical view]
PANTHER	PTHR12669. PTHR12669. 1 hit.
Pfam	PF05456. eIF_4EBP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	8637.
NextBio	32379.
SOURCE	Search...

Entry information

Entry name

4EBP3_HUMAN

Accession

Primary (citable) accession number: O60516

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2003
Last sequence update:	August 1, 1998
Last modified:	April 3, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.