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O60516

- 4EBP3_HUMAN

UniProt

O60516 - 4EBP3_HUMAN

Protein

Eukaryotic translation initiation factor 4E-binding protein 3

Gene

EIF4EBP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Regulates eIF4E activity by preventing its assembly into the eIF4F complex.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. translation repressor activity Source: UniProtKB

    GO - Biological processi

    1. negative regulation of translational initiation Source: UniProtKB

    Keywords - Molecular functioni

    Protein synthesis inhibitor

    Keywords - Biological processi

    Translation regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eukaryotic translation initiation factor 4E-binding protein 3
    Short name:
    4E-BP3
    Short name:
    eIF4E-binding protein 3
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:3290. EIF4EBP3.

    Subcellular locationi

    GO - Cellular componenti

    1. eukaryotic translation initiation factor 4F complex Source: UniProtKB
    2. membrane Source: UniProtKB

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi40 – 401Y → A: Loss of interaction with EIF4E. 1 Publication
    Mutagenesisi45 – 451L → A: Loss of interaction with EIF4E. 1 Publication

    Organism-specific databases

    PharmGKBiPA27718.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 100100Eukaryotic translation initiation factor 4E-binding protein 3PRO_0000190518Add
    BLAST

    Post-translational modificationi

    Phosphorylated.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiO60516.
    PRIDEiO60516.

    PTM databases

    PhosphoSiteiO60516.

    Expressioni

    Tissue specificityi

    Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus.1 Publication

    Gene expression databases

    BgeeiO60516.
    GenevestigatoriO60516.

    Organism-specific databases

    HPAiHPA045537.

    Interactioni

    Subunit structurei

    EIF4EBP3 interacts with EIF4E.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EIF4EP067302EBI-746950,EBI-73440
    Eif4e2Q80ZJ32EBI-746950,EBI-934970From a different organism.
    RPA2P159273EBI-746950,EBI-621404

    Protein-protein interaction databases

    BioGridi114190. 4 interactions.
    IntActiO60516. 5 interactions.
    MINTiMINT-1535204.
    STRINGi9606.ENSP00000308472.

    Structurei

    3D structure databases

    ProteinModelPortaliO60516.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eIF4E-binding protein family.Curated

    Phylogenomic databases

    eggNOGiNOG78084.
    HOGENOMiHOG000231190.
    HOVERGENiHBG050425.
    OMAiNQFEMDI.
    OrthoDBiEOG7B31Q1.
    PhylomeDBiO60516.
    TreeFamiTF101530.

    Family and domain databases

    InterProiIPR008606. EIF4EBP.
    [Graphical view]
    PfamiPF05456. eIF_4EBP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O60516-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTSTSCPIP GGRDQLPDCY STTPGGTLYA TTPGGTRIIY DRKFLLECKN    50
    SPIARTPPCC LPQIPGVTTP PTAPLSKLEE LKEQETEEEI PDDAQFEMDI 100
    Length:100
    Mass (Da):10,873
    Last modified:August 1, 1998 - v1
    Checksum:iFD29A7F3829E546E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF038869 mRNA. Translation: AAC39761.1.
    BC010881 mRNA. Translation: AAH10881.1.
    BC069293 mRNA. Translation: AAH69293.1.
    BC073751 mRNA. Translation: AAH73751.1.
    CCDSiCCDS4226.1.
    RefSeqiNP_003723.1. NM_003732.2.
    UniGeneiHs.594084.

    Genome annotation databases

    EnsembliENST00000310331; ENSP00000308472; ENSG00000243056.
    GeneIDi8637.
    KEGGihsa:8637.
    UCSCiuc003lfy.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF038869 mRNA. Translation: AAC39761.1 .
    BC010881 mRNA. Translation: AAH10881.1 .
    BC069293 mRNA. Translation: AAH69293.1 .
    BC073751 mRNA. Translation: AAH73751.1 .
    CCDSi CCDS4226.1.
    RefSeqi NP_003723.1. NM_003732.2.
    UniGenei Hs.594084.

    3D structure databases

    ProteinModelPortali O60516.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114190. 4 interactions.
    IntActi O60516. 5 interactions.
    MINTi MINT-1535204.
    STRINGi 9606.ENSP00000308472.

    PTM databases

    PhosphoSitei O60516.

    Proteomic databases

    PaxDbi O60516.
    PRIDEi O60516.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000310331 ; ENSP00000308472 ; ENSG00000243056 .
    GeneIDi 8637.
    KEGGi hsa:8637.
    UCSCi uc003lfy.1. human.

    Organism-specific databases

    CTDi 8637.
    GeneCardsi GC05P139928.
    HGNCi HGNC:3290. EIF4EBP3.
    HPAi HPA045537.
    MIMi 603483. gene.
    neXtProti NX_O60516.
    PharmGKBi PA27718.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG78084.
    HOGENOMi HOG000231190.
    HOVERGENi HBG050425.
    OMAi NQFEMDI.
    OrthoDBi EOG7B31Q1.
    PhylomeDBi O60516.
    TreeFami TF101530.

    Miscellaneous databases

    GeneWikii EIF4EBP3.
    GenomeRNAii 8637.
    NextBioi 32379.
    PROi O60516.
    SOURCEi Search...

    Gene expression databases

    Bgeei O60516.
    Genevestigatori O60516.

    Family and domain databases

    InterProi IPR008606. EIF4EBP.
    [Graphical view ]
    Pfami PF05456. eIF_4EBP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family."
      Poulin F., Gingras A.-C., Olsen H., Chevalier S., Sonenberg N.
      J. Biol. Chem. 273:14002-14007(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH EIF4E, MUTAGENESIS OF TYR-40 AND LEU-45, TISSUE SPECIFICITY.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lymph.

    Entry informationi

    Entry namei4EBP3_HUMAN
    AccessioniPrimary (citable) accession number: O60516
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3