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O60516 (4EBP3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Eukaryotic translation initiation factor 4E-binding protein 3

Short name=4E-BP3
Short name=eIF4E-binding protein 3
Gene names
Name:EIF4EBP3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length100 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulates eIF4E activity by preventing its assembly into the eIF4F complex.

Subunit structure

EIF4EBP3 interacts with EIF4E. Ref.1

Tissue specificity

Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus. Ref.1

Post-translational modification

Phosphorylated.

Sequence similarities

Belongs to the eIF4E-binding protein family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

EIF4EP067302EBI-746950,EBI-73440
Eif4e2Q80ZJ32EBI-746950,EBI-934970From a different organism.
RPA2P159273EBI-746950,EBI-621404

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 100100Eukaryotic translation initiation factor 4E-binding protein 3
PRO_0000190518

Experimental info

Mutagenesis401Y → A: Loss of interaction with EIF4E. Ref.1
Mutagenesis451L → A: Loss of interaction with EIF4E. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O60516 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: FD29A7F3829E546E

FASTA10010,873
        10         20         30         40         50         60 
MSTSTSCPIP GGRDQLPDCY STTPGGTLYA TTPGGTRIIY DRKFLLECKN SPIARTPPCC 

        70         80         90        100 
LPQIPGVTTP PTAPLSKLEE LKEQETEEEI PDDAQFEMDI 

« Hide

References

« Hide 'large scale' references
[1]"4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family."
Poulin F., Gingras A.-C., Olsen H., Chevalier S., Sonenberg N.
J. Biol. Chem. 273:14002-14007(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH EIF4E, MUTAGENESIS OF TYR-40 AND LEU-45, TISSUE SPECIFICITY.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lymph.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF038869 mRNA. Translation: AAC39761.1.
BC010881 mRNA. Translation: AAH10881.1.
BC069293 mRNA. Translation: AAH69293.1.
BC073751 mRNA. Translation: AAH73751.1.
CCDSCCDS4226.1.
RefSeqNP_003723.1. NM_003732.2.
UniGeneHs.594084.

3D structure databases

ProteinModelPortalO60516.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114190. 4 interactions.
IntActO60516. 5 interactions.
MINTMINT-1535204.
STRING9606.ENSP00000308472.

PTM databases

PhosphoSiteO60516.

Proteomic databases

PaxDbO60516.
PRIDEO60516.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000310331; ENSP00000308472; ENSG00000243056.
GeneID8637.
KEGGhsa:8637.
UCSCuc003lfy.1. human.

Organism-specific databases

CTD8637.
GeneCardsGC05P139928.
HGNCHGNC:3290. EIF4EBP3.
HPAHPA045537.
MIM603483. gene.
neXtProtNX_O60516.
PharmGKBPA27718.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG78084.
HOGENOMHOG000231190.
HOVERGENHBG050425.
OMANQFEMDI.
OrthoDBEOG7B31Q1.
PhylomeDBO60516.
TreeFamTF101530.

Gene expression databases

BgeeO60516.
GenevestigatorO60516.

Family and domain databases

InterProIPR008606. EIF4EBP.
[Graphical view]
PfamPF05456. eIF_4EBP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiEIF4EBP3.
GenomeRNAi8637.
NextBio32379.
PROO60516.
SOURCESearch...

Entry information

Entry name4EBP3_HUMAN
AccessionPrimary (citable) accession number: O60516
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM