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Protein

Eukaryotic translation initiation factor 4E-binding protein 3

Gene

EIF4EBP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation.By similarity

GO - Molecular functioni

  • eukaryotic initiation factor 4E binding Source: GO_Central
  • translation repressor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionProtein synthesis inhibitor
Biological processTranslation regulation

Enzyme and pathway databases

SIGNORiO60516.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4E-binding protein 3
Short name:
4E-BP3
Short name:
eIF4E-binding protein 3
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000243056.1.
HGNCiHGNC:3290. EIF4EBP3.

Subcellular locationi

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi40Y → A: Loss of interaction with EIF4E. 1 Publication1
Mutagenesisi45L → A: Loss of interaction with EIF4E. 1 Publication1

Organism-specific databases

DisGeNETi8637.
OpenTargetsiENSG00000243056.
PharmGKBiPA27718.

Polymorphism and mutation databases

BioMutaiEIF4EBP3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001905181 – 100Eukaryotic translation initiation factor 4E-binding protein 3Add BLAST100

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO60516.
PaxDbiO60516.
PeptideAtlasiO60516.
PRIDEiO60516.

PTM databases

iPTMnetiO60516.
PhosphoSitePlusiO60516.

Expressioni

Tissue specificityi

Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus.1 Publication

Gene expression databases

BgeeiENSG00000243056.
GenevisibleiO60516. HS.

Organism-specific databases

HPAiHPA045537.

Interactioni

Subunit structurei

EIF4EBP3 interacts with EIF4E.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114190. 8 interactors.
ELMiO60516.
IntActiO60516. 5 interactors.
MINTiMINT-1535204.
STRINGi9606.ENSP00000308472.

Structurei

3D structure databases

ProteinModelPortaliO60516.
SMRiO60516.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 46YXXXXLphi motif1 Publication7
Motifi96 – 100TOS motifBy similarity5

Sequence similaritiesi

Belongs to the eIF4E-binding protein family.Curated

Phylogenomic databases

eggNOGiENOG410J2Z0. Eukaryota.
ENOG4112779. LUCA.
GeneTreeiENSGT00390000013843.
HOGENOMiHOG000231190.
HOVERGENiHBG050425.
InParanoidiO60516.
KOiK18645.
OMAiSQLPDCY.
OrthoDBiEOG091G0ZHJ.
PhylomeDBiO60516.
TreeFamiTF101530.

Family and domain databases

InterProiView protein in InterPro
IPR008606. EIF4EBP.
PfamiView protein in Pfam
PF05456. eIF_4EBP. 1 hit.

Sequencei

Sequence statusi: Complete.

O60516-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSTSCPIP GGRDQLPDCY STTPGGTLYA TTPGGTRIIY DRKFLLECKN
60 70 80 90 100
SPIARTPPCC LPQIPGVTTP PTAPLSKLEE LKEQETEEEI PDDAQFEMDI
Length:100
Mass (Da):10,873
Last modified:August 1, 1998 - v1
Checksum:iFD29A7F3829E546E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038869 mRNA. Translation: AAC39761.1.
BC010881 mRNA. Translation: AAH10881.1.
BC069293 mRNA. Translation: AAH69293.1.
BC073751 mRNA. Translation: AAH73751.1.
CCDSiCCDS4226.1.
RefSeqiNP_003723.1. NM_003732.2.
UniGeneiHs.594084.

Genome annotation databases

EnsembliENST00000310331; ENSP00000308472; ENSG00000243056.
GeneIDi8637.
KEGGihsa:8637.
UCSCiuc003lfy.1. human.

Similar proteinsi

Entry informationi

Entry namei4EBP3_HUMAN
AccessioniPrimary (citable) accession number: O60516
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: August 1, 1998
Last modified: October 25, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families