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O60516

- 4EBP3_HUMAN

UniProt

O60516 - 4EBP3_HUMAN

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Protein
Eukaryotic translation initiation factor 4E-binding protein 3
Gene
EIF4EBP3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Regulates eIF4E activity by preventing its assembly into the eIF4F complex.

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. translation repressor activity Source: UniProtKB

GO - Biological processi

  1. negative regulation of translational initiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Protein synthesis inhibitor

Keywords - Biological processi

Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4E-binding protein 3
Short name:
4E-BP3
Short name:
eIF4E-binding protein 3
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:3290. EIF4EBP3.

Subcellular locationi

GO - Cellular componenti

  1. eukaryotic translation initiation factor 4F complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi40 – 401Y → A: Loss of interaction with EIF4E. 1 Publication
Mutagenesisi45 – 451L → A: Loss of interaction with EIF4E. 1 Publication

Organism-specific databases

PharmGKBiPA27718.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 100100Eukaryotic translation initiation factor 4E-binding protein 3
PRO_0000190518Add
BLAST

Post-translational modificationi

Phosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO60516.
PRIDEiO60516.

PTM databases

PhosphoSiteiO60516.

Expressioni

Tissue specificityi

Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus.1 Publication

Gene expression databases

BgeeiO60516.
GenevestigatoriO60516.

Organism-specific databases

HPAiHPA045537.

Interactioni

Subunit structurei

EIF4EBP3 interacts with EIF4E.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EIF4EP067302EBI-746950,EBI-73440
Eif4e2Q80ZJ32EBI-746950,EBI-934970From a different organism.
RPA2P159273EBI-746950,EBI-621404

Protein-protein interaction databases

BioGridi114190. 4 interactions.
IntActiO60516. 5 interactions.
MINTiMINT-1535204.
STRINGi9606.ENSP00000308472.

Structurei

3D structure databases

ProteinModelPortaliO60516.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG78084.
HOGENOMiHOG000231190.
HOVERGENiHBG050425.
OMAiNQFEMDI.
OrthoDBiEOG7B31Q1.
PhylomeDBiO60516.
TreeFamiTF101530.

Family and domain databases

InterProiIPR008606. EIF4EBP.
[Graphical view]
PfamiPF05456. eIF_4EBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60516-1 [UniParc]FASTAAdd to Basket

« Hide

MSTSTSCPIP GGRDQLPDCY STTPGGTLYA TTPGGTRIIY DRKFLLECKN    50
SPIARTPPCC LPQIPGVTTP PTAPLSKLEE LKEQETEEEI PDDAQFEMDI 100
Length:100
Mass (Da):10,873
Last modified:August 1, 1998 - v1
Checksum:iFD29A7F3829E546E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF038869 mRNA. Translation: AAC39761.1.
BC010881 mRNA. Translation: AAH10881.1.
BC069293 mRNA. Translation: AAH69293.1.
BC073751 mRNA. Translation: AAH73751.1.
CCDSiCCDS4226.1.
RefSeqiNP_003723.1. NM_003732.2.
UniGeneiHs.594084.

Genome annotation databases

EnsembliENST00000310331; ENSP00000308472; ENSG00000243056.
GeneIDi8637.
KEGGihsa:8637.
UCSCiuc003lfy.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF038869 mRNA. Translation: AAC39761.1 .
BC010881 mRNA. Translation: AAH10881.1 .
BC069293 mRNA. Translation: AAH69293.1 .
BC073751 mRNA. Translation: AAH73751.1 .
CCDSi CCDS4226.1.
RefSeqi NP_003723.1. NM_003732.2.
UniGenei Hs.594084.

3D structure databases

ProteinModelPortali O60516.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114190. 4 interactions.
IntActi O60516. 5 interactions.
MINTi MINT-1535204.
STRINGi 9606.ENSP00000308472.

PTM databases

PhosphoSitei O60516.

Proteomic databases

PaxDbi O60516.
PRIDEi O60516.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000310331 ; ENSP00000308472 ; ENSG00000243056 .
GeneIDi 8637.
KEGGi hsa:8637.
UCSCi uc003lfy.1. human.

Organism-specific databases

CTDi 8637.
GeneCardsi GC05P139928.
HGNCi HGNC:3290. EIF4EBP3.
HPAi HPA045537.
MIMi 603483. gene.
neXtProti NX_O60516.
PharmGKBi PA27718.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG78084.
HOGENOMi HOG000231190.
HOVERGENi HBG050425.
OMAi NQFEMDI.
OrthoDBi EOG7B31Q1.
PhylomeDBi O60516.
TreeFami TF101530.

Miscellaneous databases

GeneWikii EIF4EBP3.
GenomeRNAii 8637.
NextBioi 32379.
PROi O60516.
SOURCEi Search...

Gene expression databases

Bgeei O60516.
Genevestigatori O60516.

Family and domain databases

InterProi IPR008606. EIF4EBP.
[Graphical view ]
Pfami PF05456. eIF_4EBP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family."
    Poulin F., Gingras A.-C., Olsen H., Chevalier S., Sonenberg N.
    J. Biol. Chem. 273:14002-14007(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH EIF4E, MUTAGENESIS OF TYR-40 AND LEU-45, TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph.

Entry informationi

Entry namei4EBP3_HUMAN
AccessioniPrimary (citable) accession number: O60516
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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