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Protein

Heterogeneous nuclear ribonucleoprotein Q

Gene

SYNCRIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function.6 Publications

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • poly(A) binding Source: Ensembl
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: ProtInc

GO - Biological processi

  • cellular response to interferon-gamma Source: UniProtKB
  • CRD-mediated mRNA stabilization Source: UniProtKB
  • mRNA splicing, via spliceosome Source: UniProtKB
  • negative regulation of translation Source: UniProtKB
  • osteoblast differentiation Source: UniProtKB
  • RNA processing Source: ProtInc
  • RNA splicing Source: ProtInc
  • viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Host-virus interaction, mRNA processing, mRNA splicing, Translation regulation

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

SIGNORiO60506.

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein Q
Short name:
hnRNP Q
Alternative name(s):
Glycine- and tyrosine-rich RNA-binding protein
Short name:
GRY-RBP
NS1-associated protein 1
Synaptotagmin-binding, cytoplasmic RNA-interacting protein
Gene namesi
Name:SYNCRIP
Synonyms:HNRPQ, NSAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:16918. SYNCRIP.

Subcellular locationi

Isoform 1 :
  • Nucleusnucleoplasm By similarity

  • Note: Expressed predominantly in the nucleoplasm.By similarity
Isoform 2 :
  • Nucleusnucleoplasm By similarity

  • Note: Expressed predominantly in the nucleoplasm.By similarity
Isoform 3 :
  • Nucleusnucleoplasm By similarity

  • Note: Expressed predominantly in the nucleoplasm.By similarity

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: UniProtKB
  • CRD-mediated mRNA stability complex Source: UniProtKB
  • endoplasmic reticulum Source: UniProtKB-SubCell
  • GAIT complex Source: UniProtKB
  • histone pre-mRNA 3'end processing complex Source: UniProtKB
  • intracellular ribonucleoprotein complex Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleoplasm Source: UniProtKB-SubCell
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi10492.
OpenTargetsiENSG00000135316.
PharmGKBiPA134985065.

Polymorphism and mutation databases

BioMutaiSYNCRIP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000818672 – 623Heterogeneous nuclear ribonucleoprotein QAdd BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei159PhosphoserineCombined sources1
Modified residuei221N6-acetyllysineCombined sources1
Modified residuei363N6-acetyllysineCombined sources1
Modified residuei373Phosphotyrosine1 Publication1
Modified residuei444Asymmetric dimethylarginine; by PRMT1; alternate1 Publication1
Modified residuei444Omega-N-methylarginine; by PRMT1; alternate1 Publication1
Modified residuei496Omega-N-methylarginine; by PRMT11 Publication1
Modified residuei510Asymmetric dimethylarginine; by PRMT11 Publication1
Modified residuei518Asymmetric dimethylarginine; by PRMT1; alternate1 Publication1
Modified residuei518Omega-N-methylarginine; by PRMT1; alternate1 Publication1
Modified residuei526Asymmetric dimethylarginine; by PRMT1; alternate1 Publication1
Modified residuei526Omega-N-methylarginine; by PRMT1; alternate1 Publication1
Modified residuei536Asymmetric dimethylarginine; by PRMT1; alternate1 Publication1
Modified residuei536Omega-N-methylarginine; by PRMT1; alternate1 Publication1
Modified residuei539Asymmetric dimethylarginine; by PRMT1; alternate1 Publication1
Modified residuei539Omega-N-methylarginine; by PRMT1; alternate1 Publication1
Modified residuei587PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine. The membrane-bound form found in microsomes is phosphorylated in vitro by insulin receptor tyrosine kinase (INSR). Phosphorylation is inhibited upon binding to RNA, whereas the cytoplasmic form is poorly phosphorylated (By similarity).By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiO60506.
MaxQBiO60506.
PaxDbiO60506.
PeptideAtlasiO60506.
PRIDEiO60506.

PTM databases

iPTMnetiO60506.
PhosphoSitePlusiO60506.
SwissPalmiO60506.

Expressioni

Tissue specificityi

Ubiquitously expressed. Detected in heart, brain, pancreas, placenta, spleen, lung, liver, skeletal muscle, kidney, thymus, prostate, uterus, small intestine, colon, peripheral blood and testis.1 Publication

Gene expression databases

BgeeiENSG00000135316.
CleanExiHS_SYNCRIP.
ExpressionAtlasiO60506. baseline and differential.
GenevisibleiO60506. HS.

Organism-specific databases

HPAiCAB010895.
HPA041275.

Interactioni

Subunit structurei

Isoform 1 is a component of the APOB mRNA editosome complex and interacts with APOBEC1 and A1CF (APOBEC1 complementation factor). Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, CSDE1/UNR, HNRPD and SYNCRIP. Isoform 3 interacts with HNRPR. Interacts with POLR2A hyperphosphorylated C-terminal domain. Interacts with minute virus of mice (MVM) NS1 protein. Isoform 1, isoform 2 and isoform 3 interact with SMN. Isoform 3 interacts through its C-terminal domain with SYT7, SYT8 and SYT9 (By similarity). The non-phosphorylated and phosphorylated forms are colocalized with PAIP1 in polysomes (By similarity). Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1 (By similarity). Identified in the spliceosome C complex. Component of the coding region determinant (CRD)-mediated complex, composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with GTPBP1. Component of the GAIT complex; in humans the complex assembly seems to be a two-step process in which EPRS first associates with SYNCRIP to form a pre-GAIT complex which is deficient in GAIT element binding.By similarity13 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HABP4Q5JVS02EBI-1024357,EBI-523625
HNRNPDQ14103-43EBI-1024357,EBI-432545
PRMT1Q998732EBI-1024357,EBI-78738
PRMT8Q9NR223EBI-1024357,EBI-745545
PRMT8Q9NR22-23EBI-1024357,EBI-10186886

Protein-protein interaction databases

BioGridi115755. 303 interactors.
DIPiDIP-35540N.
IntActiO60506. 156 interactors.
MINTiMINT-2796763.
STRINGi9606.ENSP00000358635.

Structurei

Secondary structure

1623
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi25 – 32Combined sources8
Helixi37 – 48Combined sources12
Helixi59 – 66Combined sources8
Helixi70 – 81Combined sources12
Helixi91 – 103Combined sources13
Beta strandi340 – 343Combined sources4
Helixi351 – 361Combined sources11
Beta strandi364 – 369Combined sources6
Beta strandi374 – 380Combined sources7
Helixi381 – 391Combined sources11
Beta strandi394 – 396Combined sources3
Beta strandi399 – 405Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DGUNMR-A334-423[»]
2MXTNMR-A24-107[»]
2NBBNMR-A24-140[»]
ProteinModelPortaliO60506.
SMRiO60506.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60506.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini162 – 241RRM 1PROSITE-ProRule annotationAdd BLAST80
Domaini243 – 325RRM 2PROSITE-ProRule annotationAdd BLAST83
Domaini338 – 408RRM 3PROSITE-ProRule annotationAdd BLAST71
Repeati448 – 4501-13
Repeati451 – 4531-23
Repeati460 – 4642-15
Repeati469 – 4722-24
Repeati478 – 4801-33
Repeati485 – 4882-34
Repeati498 – 5001-43
Repeati526 – 5281-53
Repeati539 – 5411-63
Repeati554 – 5561-73
Repeati557 – 5591-83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni400 – 561Interaction with APOBEC1Add BLAST162
Regioni448 – 5598 X 3 AA repeats of R-G-GAdd BLAST112
Regioni460 – 4883 X 4 AA repeats of Y-Y-G-YAdd BLAST29
Regioni518 – 549Interaction with SMN1 PublicationAdd BLAST32

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi564 – 578Bipartite nuclear localization signalSequence analysisAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi431 – 434Poly-Tyr4

Domaini

The domain containing eight Arg-Gly-Gly repeats (RGG/RXR-box) may be involved in RNA-binding and protein-protein interactions. It is methylated by PRMT1, and essential for nuclear localization.

Sequence similaritiesi

Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0117. Eukaryota.
ENOG410XTJ5. LUCA.
GeneTreeiENSGT00550000074366.
HOVERGENiHBG051917.
InParanoidiO60506.
KOiK13160.
OMAiMATDHVN.
OrthoDBiEOG091G0EUB.
PhylomeDBiO60506.
TreeFamiTF314932.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR006535. HnRNP_R/Q_splicing_fac.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
TIGRFAMsiTIGR01648. hnRNP-R-Q. 1 hit.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60506-1) [UniParc]FASTAAdd to basket
Also known as: hnRNP Q3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATEHVNGNG TEEPMDTTSA VIHSENFQTL LDAGLPQKVA EKLDEIYVAG
60 70 80 90 100
LVAHSDLDER AIEALKEFNE DGALAVLQQF KDSDLSHVQN KSAFLCGVMK
110 120 130 140 150
TYRQREKQGT KVADSSKGPD EAKIKALLER TGYTLDVTTG QRKYGGPPPD
160 170 180 190 200
SVYSGQQPSV GTEIFVGKIP RDLFEDELVP LFEKAGPIWD LRLMMDPLTG
210 220 230 240 250
LNRGYAFVTF CTKEAAQEAV KLYNNHEIRS GKHIGVCISV ANNRLFVGSI
260 270 280 290 300
PKSKTKEQIL EEFSKVTEGL TDVILYHQPD DKKKNRGFCF LEYEDHKTAA
310 320 330 340 350
QARRRLMSGK VKVWGNVGTV EWADPIEDPD PEVMAKVKVL FVRNLANTVT
360 370 380 390 400
EEILEKAFSQ FGKLERVKKL KDYAFIHFDE RDGAVKAMEE MNGKDLEGEN
410 420 430 440 450
IEIVFAKPPD QKRKERKAQR QAAKNQMYDD YYYYGPPHMP PPTRGRGRGG
460 470 480 490 500
RGGYGYPPDY YGYEDYYDYY GYDYHNYRGG YEDPYYGYED FQVGARGRGG
510 520 530 540 550
RGARGAAPSR GRGAAPPRGR AGYSQRGGPG SARGVRGARG GAQQQRGRGV
560 570 580 590 600
RGARGGRGGN VGGKRKADGY NQPDSKRRQT NNQNWGSQPI AQQPLQGGDH
610 620
SGNYGYKSEN QEFYQDTFGQ QWK
Length:623
Mass (Da):69,603
Last modified:March 7, 2006 - v2
Checksum:i0669FA604E8FBBDF
GO
Isoform 2 (identifier: O60506-2) [UniParc]FASTAAdd to basket
Also known as: hnRNP Q2

The sequence of this isoform differs from the canonical sequence as follows:
     302-336: Missing.

Note: May be due to a competing donor splice site.
Show »
Length:588
Mass (Da):65,682
Checksum:i907A3EFBF5502D3F
GO
Isoform 3 (identifier: O60506-3) [UniParc]FASTAAdd to basket
Also known as: hnRNP Q1

The sequence of this isoform differs from the canonical sequence as follows:
     550-623: VRGARGGRGG...YQDTFGQQWK → QGKGVEAGPDLLQ

Note: May be due to a competing donor splice site and to an exon inclusion.Curated
Show »
Length:562
Mass (Da):62,656
Checksum:i32F5C37178197E45
GO
Isoform 4 (identifier: O60506-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     302-336: Missing.
     550-623: VRGARGGRGG...YQDTFGQQWK → QGKGVEAGPDLLQ

Note: May be due to a competing donor splice site and to an exon inclusion. No experimental confirmation available.
Show »
Length:527
Mass (Da):58,736
Checksum:iC17388F6F991A127
GO
Isoform 5 (identifier: O60506-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-152: Missing.
     153-163: YSGQQPSVGTE → MEDHLQIPFIQ
     550-623: VRGARGGRGG...YQDTFGQQWK → QGKGVEAGPDLLQ

Note: May be due to a competing donor splice site and to an exon inclusion.
Show »
Length:410
Mass (Da):46,328
Checksum:i4F1AD0FE9570F7BD
GO

Sequence cautioni

The sequence AAH15575 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 413.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti265K → Q in AAD38198 (PubMed:9847309).Curated1
Sequence conflicti287G → S (Ref. 2) Curated1
Sequence conflicti287G → S (PubMed:11574476).Curated1
Sequence conflicti288F → S in AAH40844 (PubMed:15489334).Curated1
Isoform 3 (identifier: O60506-3)
Sequence conflicti550 – 551QG → V in AAK59705 (PubMed:14574404).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0095811 – 152Missing in isoform 5. 1 PublicationAdd BLAST152
Alternative sequenceiVSP_009582153 – 163YSGQQPSVGTE → MEDHLQIPFIQ in isoform 5. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_009583302 – 336Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST35
Alternative sequenceiVSP_009584550 – 623VRGAR…GQQWK → QGKGVEAGPDLLQ in isoform 3, isoform 4 and isoform 5. 3 PublicationsAdd BLAST74

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155568 mRNA. Translation: AAD38198.1.
AF037448 mRNA. Translation: AAC12926.1.
AY034481 mRNA. Translation: AAK59703.1.
AY034482 mRNA. Translation: AAK59704.1.
AY034483 mRNA. Translation: AAK59705.1.
AK222776 mRNA. Translation: BAD96496.1.
AL136082 Genomic DNA. Translation: CAI20446.1.
AL136082 Genomic DNA. Translation: CAI20447.1.
CH471051 Genomic DNA. Translation: EAW48625.1.
CH471051 Genomic DNA. Translation: EAW48626.1.
CH471051 Genomic DNA. Translation: EAW48629.1.
CH471051 Genomic DNA. Translation: EAW48630.1.
BC015575 mRNA. Translation: AAH15575.1. Sequence problems.
BC032643 mRNA. Translation: AAH32643.1.
BC040844 mRNA. Translation: AAH40844.1.
CCDSiCCDS5005.1. [O60506-1]
CCDS55041.1. [O60506-3]
RefSeqiNP_001153145.1. NM_001159673.1.
NP_001153146.1. NM_001159674.1. [O60506-4]
NP_001153147.1. NM_001159675.1. [O60506-2]
NP_001153148.1. NM_001159676.1.
NP_001153149.1. NM_001159677.1. [O60506-3]
NP_001240700.1. NM_001253771.1. [O60506-5]
NP_006363.4. NM_006372.4. [O60506-1]
XP_005248694.1. XM_005248637.2. [O60506-1]
XP_016865667.1. XM_017010178.1. [O60506-3]
UniGeneiHs.571177.

Genome annotation databases

EnsembliENST00000355238; ENSP00000347380; ENSG00000135316. [O60506-3]
ENST00000369622; ENSP00000358635; ENSG00000135316. [O60506-1]
GeneIDi10492.
KEGGihsa:10492.
UCSCiuc003pkv.4. human. [O60506-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155568 mRNA. Translation: AAD38198.1.
AF037448 mRNA. Translation: AAC12926.1.
AY034481 mRNA. Translation: AAK59703.1.
AY034482 mRNA. Translation: AAK59704.1.
AY034483 mRNA. Translation: AAK59705.1.
AK222776 mRNA. Translation: BAD96496.1.
AL136082 Genomic DNA. Translation: CAI20446.1.
AL136082 Genomic DNA. Translation: CAI20447.1.
CH471051 Genomic DNA. Translation: EAW48625.1.
CH471051 Genomic DNA. Translation: EAW48626.1.
CH471051 Genomic DNA. Translation: EAW48629.1.
CH471051 Genomic DNA. Translation: EAW48630.1.
BC015575 mRNA. Translation: AAH15575.1. Sequence problems.
BC032643 mRNA. Translation: AAH32643.1.
BC040844 mRNA. Translation: AAH40844.1.
CCDSiCCDS5005.1. [O60506-1]
CCDS55041.1. [O60506-3]
RefSeqiNP_001153145.1. NM_001159673.1.
NP_001153146.1. NM_001159674.1. [O60506-4]
NP_001153147.1. NM_001159675.1. [O60506-2]
NP_001153148.1. NM_001159676.1.
NP_001153149.1. NM_001159677.1. [O60506-3]
NP_001240700.1. NM_001253771.1. [O60506-5]
NP_006363.4. NM_006372.4. [O60506-1]
XP_005248694.1. XM_005248637.2. [O60506-1]
XP_016865667.1. XM_017010178.1. [O60506-3]
UniGeneiHs.571177.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DGUNMR-A334-423[»]
2MXTNMR-A24-107[»]
2NBBNMR-A24-140[»]
ProteinModelPortaliO60506.
SMRiO60506.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115755. 303 interactors.
DIPiDIP-35540N.
IntActiO60506. 156 interactors.
MINTiMINT-2796763.
STRINGi9606.ENSP00000358635.

PTM databases

iPTMnetiO60506.
PhosphoSitePlusiO60506.
SwissPalmiO60506.

Polymorphism and mutation databases

BioMutaiSYNCRIP.

Proteomic databases

EPDiO60506.
MaxQBiO60506.
PaxDbiO60506.
PeptideAtlasiO60506.
PRIDEiO60506.

Protocols and materials databases

DNASUi10492.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355238; ENSP00000347380; ENSG00000135316. [O60506-3]
ENST00000369622; ENSP00000358635; ENSG00000135316. [O60506-1]
GeneIDi10492.
KEGGihsa:10492.
UCSCiuc003pkv.4. human. [O60506-1]

Organism-specific databases

CTDi10492.
DisGeNETi10492.
GeneCardsiSYNCRIP.
HGNCiHGNC:16918. SYNCRIP.
HPAiCAB010895.
HPA041275.
neXtProtiNX_O60506.
OpenTargetsiENSG00000135316.
PharmGKBiPA134985065.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0117. Eukaryota.
ENOG410XTJ5. LUCA.
GeneTreeiENSGT00550000074366.
HOVERGENiHBG051917.
InParanoidiO60506.
KOiK13160.
OMAiMATDHVN.
OrthoDBiEOG091G0EUB.
PhylomeDBiO60506.
TreeFamiTF314932.

Enzyme and pathway databases

SIGNORiO60506.

Miscellaneous databases

ChiTaRSiSYNCRIP. human.
EvolutionaryTraceiO60506.
GeneWikiiSYNCRIP.
GenomeRNAii10492.
PROiO60506.

Gene expression databases

BgeeiENSG00000135316.
CleanExiHS_SYNCRIP.
ExpressionAtlasiO60506. baseline and differential.
GenevisibleiO60506. HS.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR006535. HnRNP_R/Q_splicing_fac.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
TIGRFAMsiTIGR01648. hnRNP-R-Q. 1 hit.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHNRPQ_HUMAN
AccessioniPrimary (citable) accession number: O60506
Secondary accession number(s): E1P501
, E1P502, Q53H05, Q5TCG2, Q5TCG3, Q8IW78, Q8N599, Q96LC1, Q96LC2, Q9Y583
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 7, 2006
Last modified: November 30, 2016
This is version 167 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.