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O60504 (VINEX_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 146. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vinexin
Alternative name(s):
SH3-containing adapter molecule 1
Short name=SCAM-1
Sorbin and SH3 domain-containing protein 3
Gene names
Name:SORBS3
Synonyms:SCAM1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length671 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Vinexin alpha isoform promotesup-regulation of actin stress fiber formation. Vinexin beta isoform playsa role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.

Subunit structure

Interacts with DLG5 through its third SH3 domain By similarity. Interacts with vinculin by the first two SH3 domains and the proline rich region of vinculin. Binds to SOS (guanine nucleotide exchange factor of RAS and RAC), through its third SH3 domain. The formation of this complex is down-regulated by phosphorylation of SOS. Interacts with INPPL1/SHIP2, SAFB2, SOCS7 and SRCIN1. Interacts with FASLG. Interacts with MAPK1/ERK2 By similarity. Ref.6 Ref.7 Ref.8 Ref.9 Ref.12 Ref.14

Subcellular location

Isoform Alpha: Cell junction By similarity. Cytoplasmcytoskeleton By similarity. Note: Localized at cell-extracellular matrix junctions By similarity. Both isoforms were localized at focal adhesion and cell-cell adhesion sites.

Isoform Beta: Cell junction By similarity. Nucleus. Cytoplasmcytoskeleton By similarity. Note: Localized at cell-extracellular matrix junctions By similarity. Both isoforms were localized at focal adhesion and cell-cell adhesion sites, vinexin beta was also found in the nucleus.

Tissue specificity

Both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform betais especially found in liver.

Post-translational modification

Phosphorylated at Ser-530 by MAPK1/ERK2 during cell spreading By similarity.

Sequence similarities

Contains 3 SH3 domains.

Contains 1 SoHo domain.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentCell junction
Cytoplasm
Cytoskeleton
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
SH3 domain
   PTMPhosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Traceable author statement Ref.1. Source: ProtInc

cell-substrate adhesion

Inferred from electronic annotation. Source: Ensembl

muscle contraction

Traceable author statement. Source: Reactome

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

positive regulation of MAPK cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytoskeleton organization

Non-traceable author statement Ref.1. Source: UniProtKB

positive regulation of stress fiber assembly

Inferred from direct assay Ref.1. Source: UniProtKB

   Cellular_componentcytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

cytosol

Traceable author statement. Source: Reactome

focal adhesion

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein binding

Inferred from physical interaction Ref.7PubMed 16374509PubMed 19294487PubMed 21516116Ref.9PubMed 15734736PubMed 16483316PubMed 16831423Ref.12PubMed 19294487. Source: IntAct

structural constituent of cytoskeleton

Traceable author statement Ref.1. Source: ProtInc

vinculin binding

Inferred from physical interaction Ref.1. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Alpha (identifier: O60504-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Beta (identifier: O60504-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-342: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 671671Vinexin
PRO_0000065830

Regions

Domain115 – 18773SoHo
Domain380 – 43960SH3 1
Domain454 – 51562SH3 2
Domain612 – 67160SH3 3
Region380 – 515136Binds to vinculin
Region612 – 67160Binds to SOS

Amino acid modifications

Modified residue3481Phosphoserine Ref.15 Ref.17
Modified residue3951Phosphoserine Ref.17
Modified residue5301Phosphoserine; by MAPK1 Ref.11 Ref.13 Ref.16 Ref.17
Modified residue5441Phosphoserine Ref.18
Modified residue5451Phosphoserine Ref.17 Ref.18
Modified residue5511Phosphoserine Ref.13 Ref.17
Modified residue5631Phosphoserine Ref.13 Ref.16 Ref.17 Ref.18

Natural variations

Alternative sequence1 – 342342Missing in isoform Beta.
VSP_004489
Natural variant2551P → L.
Corresponds to variant rs3758036 [ dbSNP | Ensembl ].
VAR_057019
Natural variant5561I → T. Ref.1 Ref.2 Ref.3 Ref.5 Ref.13 Ref.15 Ref.16 Ref.17 Ref.18 Ref.21 Ref.22 Ref.23
Corresponds to variant rs2449331 [ dbSNP | Ensembl ].
VAR_055019
Natural variant5731T → A.
Corresponds to variant rs1047030 [ dbSNP | Ensembl ].
VAR_055020

Experimental info

Mutagenesis6491W → F: Loss of SOS-binding ability.
Mutagenesis6671Y → V: Loss of SOS-binding ability.
Sequence conflict5831L → F in AAD32304. Ref.1

Secondary structure

....................................... 671
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform Alpha [UniParc].

Last modified January 11, 2011. Version 2.
Checksum: 2D8A8718E0367BE9

FASTA67175,341
        10         20         30         40         50         60 
MQGPPRSLRA GLSLDDFIPG HLQSHIGSSS RGTRVPVIRN GGSNTLNFQF HDPAPRTVCN 

        70         80         90        100        110        120 
GGYTPRRDAS QHPDPAWYQT WPGPGSKPSA STKIPASQHT QNWSATWTKD SKRRDKRWVK 

       130        140        150        160        170        180 
YEGIGPVDES GMPIAPRSSV DRPRDWYRRM FQQIHRKMPD LQLDWTFEEP PRDPRHLGAQ 

       190        200        210        220        230        240 
QRPAHRPGPA TSSSGRSWDH SEELPRSTFN YRPGAFSTVL QPSNQVLRRR EKVDNVWTEE 

       250        260        270        280        290        300 
SWNQFLQELE TGQRPKKPLV DDPGEKPSQP IEVLLERELA ELSAELDKDL RAIETRLPSP 

       310        320        330        340        350        360 
KSSPAPRRAP EQRPPAGPAS AWSSSYPHAP YLGSARSLSP HKMADGGSPF LGRRDFVYPS 

       370        380        390        400        410        420 
STRDPSASNG GGSPARREEK KRKAARLKFD FQAQSPKELT LQKGDIVYIH KEVDKNWLEG 

       430        440        450        460        470        480 
EHHGRLGIFP ANYVEVLPAD EIPKPIKPPT YQVLEYGEAV AQYTFKGDLE VELSFRKGEH 

       490        500        510        520        530        540 
ICLIRKVNEN WYEGRITGTG RQGIFPASYV QVSREPRLRL CDDGPQLPTS PRLTAAARSA 

       550        560        570        580        590        600 
RHPSSPSALR SPADPIDLGG QTSPRRTGFS FPTQEPRPQT QNLGTPGPAL SHSRGPSHPL 

       610        620        630        640        650        660 
DLGTSSPNTS QIHWTPYRAM YQYRPQNEDE LELREGDRVD VMQQCDDGWF VGVSRRTQKF 

       670 
GTFPGNYVAP V 

« Hide

Isoform Beta [UniParc].

Checksum: 852B1FDC07859AC2
Show »

FASTA32936,742

References

« Hide 'large scale' references
[1]"Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization."
Kioka N., Sakata S., Kawauchi T., Amachi T., Akiyama S.K., Okazaki K., Yaen C., Yamada K.M., Aota S.
J. Cell Biol. 144:59-69(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA), ALTERNATIVE SPLICING, MUTAGENESIS, VARIANT THR-556.
Tissue: Placenta.
[2]Her J.-H., Gorman D., Miyajima A., Bolen J.B.
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA), VARIANT THR-556.
[3]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-556.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS ALPHA AND BETA), VARIANT THR-556.
Tissue: PNS and Uterus.
[6]"Vinexin forms a signaling complex with Sos and modulates epidermal growth factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activities."
Akamatsu M., Aota S., Suwa A., Ueda K., Amachi T., Yamada K.M., Akiyama S.K., Kioka N.
J. Biol. Chem. 274:35933-35937(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SOS.
[7]"SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor."
Townson S.M., Dobrzycka K.M., Lee A.V., Air M., Deng W., Kang K., Jiang S., Kioka N., Michaelis K., Oesterreich S.
J. Biol. Chem. 278:20059-20068(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SAFB2.
[8]"The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin."
Martens N., Wery M., Wang P., Braet F., Gertler A., Hooghe R., Vandenhaute J., Hooghe-Peters E.L.
Exp. Cell Res. 298:239-248(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SOCS7.
[9]"SHIP2 interaction with the cytoskeletal protein Vinexin."
Paternotte N., Zhang J., Vandenbroere I., Backers K., Blero D., Kioka N., Vanderwinden J.-M., Pirson I., Erneux C.
FEBS J. 272:6052-6066(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH INPPL1.
[10]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-530, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"Characterization of a multidomain adaptor protein, p140Cap, as part of a pre-synaptic complex."
Ito H., Atsuzawa K., Sudo K., Di Stefano P., Iwamoto I., Morishita R., Takei S., Semba R., Defilippi P., Asano T., Usuda N., Nagata K.
J. Neurochem. 107:61-72(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SRCIN1.
[13]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-530; SER-551 AND SER-563, VARIANT [LARGE SCALE ANALYSIS] THR-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[14]"Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
Voss M., Lettau M., Janssen O.
BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FASLG.
[15]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-348, VARIANT [LARGE SCALE ANALYSIS] THR-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[16]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-530 AND SER-563, VARIANT [LARGE SCALE ANALYSIS] THR-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[17]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-348; SER-395; SER-530; SER-545; SER-551 AND SER-563, VARIANT [LARGE SCALE ANALYSIS] THR-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[18]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-544; SER-545 AND SER-563, VARIANT [LARGE SCALE ANALYSIS] THR-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[19]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[20]"Solution structure of SH3 domains of human vinexin."
RIKEN structural genomics initiative (RSGI)
Submitted (OCT-2006) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 383-437 AND 615-671.
[21]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[22]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[23]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF064807 mRNA. Translation: AAD32304.1.
AF037261 mRNA. Translation: AAC09244.1.
AC037459 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63675.1.
BC067260 mRNA. Translation: AAH67260.2.
BC091514 mRNA. Translation: AAH91514.1.
BC010146 mRNA. Translation: AAH10146.1.
CCDSCCDS47824.1. [O60504-2]
CCDS6031.1. [O60504-1]
RefSeqNP_001018003.1. NM_001018003.2. [O60504-2]
NP_005766.3. NM_005775.4. [O60504-1]
XP_005273428.1. XM_005273371.1. [O60504-2]
XP_006716330.1. XM_006716267.1. [O60504-1]
XP_006716332.1. XM_006716269.1. [O60504-2]
XP_006716333.1. XM_006716270.1. [O60504-2]
XP_006716334.1. XM_006716271.1. [O60504-2]
UniGeneHs.528572.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2CT3NMR-A615-671[»]
2DLMNMR-A383-437[»]
2NWMNMR-A383-438[»]
2YUPNMR-A447-523[»]
ProteinModelPortalO60504.
SMRO60504. Positions 354-525, 615-671.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115475. 30 interactions.
IntActO60504. 30 interactions.
MINTMINT-262486.
STRING9606.ENSP00000240123.

PTM databases

PhosphoSiteO60504.

Proteomic databases

MaxQBO60504.
PaxDbO60504.
PRIDEO60504.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000240123; ENSP00000240123; ENSG00000120896. [O60504-1]
ENST00000428103; ENSP00000408476; ENSG00000120896. [O60504-2]
GeneID10174.
KEGGhsa:10174.
UCSCuc003xbv.3. human. [O60504-1]
uc003xbw.4. human. [O60504-2]

Organism-specific databases

CTD10174.
GeneCardsGC08P022409.
H-InvDBHIX0201306.
HGNCHGNC:30907. SORBS3.
HPAHPA015849.
HPA048034.
MIM610795. gene.
neXtProtNX_O60504.
PharmGKBPA128394570.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG256936.
HOGENOMHOG000294090.
HOVERGENHBG054842.
InParanoidO60504.
OMAHWTPYRA.
OrthoDBEOG7WX08W.
PhylomeDBO60504.
TreeFamTF320680.

Enzyme and pathway databases

ReactomeREACT_17044. Muscle contraction.
SignaLinkO60504.

Gene expression databases

ArrayExpressO60504.
BgeeO60504.
CleanExHS_SORBS3.
GenevestigatorO60504.

Family and domain databases

InterProIPR001452. SH3_domain.
IPR003127. Sorb.
IPR028510. Vinexin.
[Graphical view]
PANTHERPTHR10661:SF68. PTHR10661:SF68. 1 hit.
PfamPF00018. SH3_1. 1 hit.
PF14604. SH3_9. 2 hits.
PF02208. Sorb. 1 hit.
[Graphical view]
PRINTSPR00452. SH3DOMAIN.
SMARTSM00326. SH3. 3 hits.
SM00459. Sorb. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 3 hits.
PROSITEPS50002. SH3. 3 hits.
PS50831. SOHO. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSORBS3. human.
EvolutionaryTraceO60504.
GeneWikiSORBS3.
GenomeRNAi10174.
NextBio38520.
PROO60504.
SOURCESearch...

Entry information

Entry nameVINEX_HUMAN
AccessionPrimary (citable) accession number: O60504
Secondary accession number(s): Q5BJE4 expand/collapse secondary AC list , Q6NX54, Q96FY4, Q9UQE4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM