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Protein

Vinexin

Gene

SORBS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.

GO - Molecular functioni

  1. structural constituent of cytoskeleton Source: ProtInc
  2. vinculin binding Source: UniProtKB

GO - Biological processi

  1. actin filament organization Source: InterPro
  2. cell adhesion Source: ProtInc
  3. cell-substrate adhesion Source: Ensembl
  4. muscle contraction Source: Reactome
  5. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  6. positive regulation of cytoskeleton organization Source: UniProtKB
  7. positive regulation of MAPK cascade Source: Ensembl
  8. positive regulation of stress fiber assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_20558. Smooth Muscle Contraction.
SignaLinkiO60504.

Names & Taxonomyi

Protein namesi
Recommended name:
Vinexin
Alternative name(s):
SH3-containing adapter molecule 1
Short name:
SCAM-1
Sorbin and SH3 domain-containing protein 3
Gene namesi
Name:SORBS3
Synonyms:SCAM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:30907. SORBS3.

Subcellular locationi

Isoform Alpha : Cell junction By similarity. Cytoplasmcytoskeleton By similarity
Note: Localized at cell-extracellular matrix junctions (By similarity). Both isoforms were localized at focal adhesion and cell-cell adhesion sites.By similarity
Isoform Beta : Cell junction By similarity. Nucleus. Cytoplasmcytoskeleton By similarity
Note: Localized at cell-extracellular matrix junctions (By similarity). Both isoforms were localized at focal adhesion and cell-cell adhesion sites, vinexin beta was also found in the nucleus.By similarity

GO - Cellular componenti

  1. cytoskeleton Source: UniProtKB-SubCell
  2. cytosol Source: Reactome
  3. focal adhesion Source: UniProtKB
  4. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi649 – 6491W → F: Loss of SOS-binding ability. 1 Publication
Mutagenesisi667 – 6671Y → V: Loss of SOS-binding ability. 1 Publication

Organism-specific databases

PharmGKBiPA128394570.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 671671VinexinPRO_0000065830Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei348 – 3481Phosphoserine1 Publication
Modified residuei395 – 3951Phosphoserine1 Publication
Modified residuei530 – 5301Phosphoserine; by MAPK15 Publications
Modified residuei544 – 5441Phosphoserine1 Publication
Modified residuei545 – 5451Phosphoserine2 Publications
Modified residuei547 – 5471Phosphoserine1 Publication
Modified residuei551 – 5511Phosphoserine3 Publications
Modified residuei563 – 5631Phosphoserine4 Publications

Post-translational modificationi

Phosphorylated at Ser-530 by MAPK1/ERK2 during cell spreading.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO60504.
PaxDbiO60504.
PRIDEiO60504.

PTM databases

PhosphoSiteiO60504.

Expressioni

Tissue specificityi

Both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform beta is especially found in liver.

Gene expression databases

BgeeiO60504.
CleanExiHS_SORBS3.
ExpressionAtlasiO60504. baseline and differential.
GenevestigatoriO60504.

Organism-specific databases

HPAiHPA015849.
HPA048034.

Interactioni

Subunit structurei

Interacts with DLG5 through its third SH3 domain (By similarity). Interacts with vinculin by the first two SH3 domains and the proline rich region of vinculin. Binds to SOS (guanine nucleotide exchange factor of RAS and RAC), through its third SH3 domain. The formation of this complex is down-regulated by phosphorylation of SOS. Interacts with INPPL1/SHIP2, SAFB2, SOCS7 and SRCIN1. Interacts with FASLG. Interacts with MAPK1/ERK2 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ABL1P005195EBI-1222956,EBI-375543
INPPL1O153572EBI-1222953,EBI-1384248
PAK2Q131773EBI-741237,EBI-1045887
RARGP136312EBI-1222956,EBI-2568901
RTKNQ9BST93EBI-741237,EBI-446694
SAFB2Q141513EBI-1222956,EBI-352869
Srcin1Q9QWI6-24EBI-1222956,EBI-775607From a different organism.
WASF2Q9Y6W53EBI-1222956,EBI-4290615
WASLO004013EBI-1222956,EBI-957615

Protein-protein interaction databases

BioGridi115475. 52 interactions.
IntActiO60504. 31 interactions.
MINTiMINT-262486.
STRINGi9606.ENSP00000240123.

Structurei

Secondary structure

1
671
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi385 – 3895Combined sources
Beta strandi395 – 3984Combined sources
Beta strandi406 – 4149Combined sources
Beta strandi417 – 4226Combined sources
Beta strandi425 – 43511Combined sources
Helixi453 – 4553Combined sources
Beta strandi456 – 4616Combined sources
Beta strandi469 – 4724Combined sources
Beta strandi480 – 4856Combined sources
Beta strandi489 – 4957Combined sources
Turni497 – 4993Combined sources
Beta strandi502 – 5065Combined sources
Helixi507 – 5093Combined sources
Beta strandi510 – 5145Combined sources
Beta strandi615 – 6217Combined sources
Beta strandi637 – 6448Combined sources
Beta strandi646 – 6483Combined sources
Beta strandi650 – 6578Combined sources
Beta strandi660 – 6634Combined sources
Turni665 – 6673Combined sources
Beta strandi668 – 6703Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CT3NMR-A615-671[»]
2DLMNMR-A383-437[»]
2NWMNMR-A383-438[»]
2YUPNMR-A447-523[»]
ProteinModelPortaliO60504.
SMRiO60504. Positions 354-525, 615-671.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60504.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini115 – 18773SoHoPROSITE-ProRule annotationAdd
BLAST
Domaini380 – 43960SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini454 – 51562SH3 2PROSITE-ProRule annotationAdd
BLAST
Domaini612 – 67160SH3 3PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni380 – 515136Binds to vinculinAdd
BLAST
Regioni612 – 67160Binds to SOSAdd
BLAST

Sequence similaritiesi

Contains 3 SH3 domains.PROSITE-ProRule annotation
Contains 1 SoHo domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiNOG256936.
GeneTreeiENSGT00760000119190.
HOGENOMiHOG000294090.
HOVERGENiHBG054842.
InParanoidiO60504.
OMAiHWTPYRA.
OrthoDBiEOG7WX08W.
PhylomeDBiO60504.
TreeFamiTF320680.

Family and domain databases

InterProiIPR001452. SH3_domain.
IPR003127. Sorb.
IPR028510. Vinexin.
[Graphical view]
PANTHERiPTHR10661:SF68. PTHR10661:SF68. 1 hit.
PfamiPF00018. SH3_1. 1 hit.
PF14604. SH3_9. 2 hits.
PF02208. Sorb. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 3 hits.
SM00459. Sorb. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 3 hits.
PROSITEiPS50002. SH3. 3 hits.
PS50831. SOHO. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Alpha (identifier: O60504-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQGPPRSLRA GLSLDDFIPG HLQSHIGSSS RGTRVPVIRN GGSNTLNFQF
60 70 80 90 100
HDPAPRTVCN GGYTPRRDAS QHPDPAWYQT WPGPGSKPSA STKIPASQHT
110 120 130 140 150
QNWSATWTKD SKRRDKRWVK YEGIGPVDES GMPIAPRSSV DRPRDWYRRM
160 170 180 190 200
FQQIHRKMPD LQLDWTFEEP PRDPRHLGAQ QRPAHRPGPA TSSSGRSWDH
210 220 230 240 250
SEELPRSTFN YRPGAFSTVL QPSNQVLRRR EKVDNVWTEE SWNQFLQELE
260 270 280 290 300
TGQRPKKPLV DDPGEKPSQP IEVLLERELA ELSAELDKDL RAIETRLPSP
310 320 330 340 350
KSSPAPRRAP EQRPPAGPAS AWSSSYPHAP YLGSARSLSP HKMADGGSPF
360 370 380 390 400
LGRRDFVYPS STRDPSASNG GGSPARREEK KRKAARLKFD FQAQSPKELT
410 420 430 440 450
LQKGDIVYIH KEVDKNWLEG EHHGRLGIFP ANYVEVLPAD EIPKPIKPPT
460 470 480 490 500
YQVLEYGEAV AQYTFKGDLE VELSFRKGEH ICLIRKVNEN WYEGRITGTG
510 520 530 540 550
RQGIFPASYV QVSREPRLRL CDDGPQLPTS PRLTAAARSA RHPSSPSALR
560 570 580 590 600
SPADPIDLGG QTSPRRTGFS FPTQEPRPQT QNLGTPGPAL SHSRGPSHPL
610 620 630 640 650
DLGTSSPNTS QIHWTPYRAM YQYRPQNEDE LELREGDRVD VMQQCDDGWF
660 670
VGVSRRTQKF GTFPGNYVAP V
Length:671
Mass (Da):75,341
Last modified:January 11, 2011 - v2
Checksum:i2D8A8718E0367BE9
GO
Isoform Beta (identifier: O60504-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-342: Missing.

Note: Contains a phosphoserine at position 6. Initiator Met-1 is removed. Contains a N-acetylalanine at position 2.3 Publications

Show »
Length:329
Mass (Da):36,742
Checksum:i852B1FDC07859AC2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti583 – 5831L → F in AAD32304 (PubMed:9885244).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti255 – 2551P → L.
Corresponds to variant rs3758036 [ dbSNP | Ensembl ].
VAR_057019
Natural varianti556 – 5561I → T.13 Publications
Corresponds to variant rs2449331 [ dbSNP | Ensembl ].
VAR_055019
Natural varianti573 – 5731T → A.
Corresponds to variant rs1047030 [ dbSNP | Ensembl ].
VAR_055020

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 342342Missing in isoform Beta. 2 PublicationsVSP_004489Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064807 mRNA. Translation: AAD32304.1.
AF037261 mRNA. Translation: AAC09244.1.
AC037459 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63675.1.
BC067260 mRNA. Translation: AAH67260.2.
BC091514 mRNA. Translation: AAH91514.1.
BC010146 mRNA. Translation: AAH10146.1.
CCDSiCCDS6031.1. [O60504-1]
RefSeqiNP_001018003.1. NM_001018003.2. [O60504-2]
NP_005766.3. NM_005775.4. [O60504-1]
XP_005273428.1. XM_005273371.1. [O60504-2]
XP_006716330.1. XM_006716267.1. [O60504-1]
XP_006716332.1. XM_006716269.1. [O60504-2]
XP_006716333.1. XM_006716270.1. [O60504-2]
XP_006716334.1. XM_006716271.1. [O60504-2]
UniGeneiHs.528572.

Genome annotation databases

EnsembliENST00000240123; ENSP00000240123; ENSG00000120896. [O60504-1]
GeneIDi10174.
KEGGihsa:10174.
UCSCiuc003xbv.3. human. [O60504-1]
uc003xbw.4. human. [O60504-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064807 mRNA. Translation: AAD32304.1.
AF037261 mRNA. Translation: AAC09244.1.
AC037459 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63675.1.
BC067260 mRNA. Translation: AAH67260.2.
BC091514 mRNA. Translation: AAH91514.1.
BC010146 mRNA. Translation: AAH10146.1.
CCDSiCCDS6031.1. [O60504-1]
RefSeqiNP_001018003.1. NM_001018003.2. [O60504-2]
NP_005766.3. NM_005775.4. [O60504-1]
XP_005273428.1. XM_005273371.1. [O60504-2]
XP_006716330.1. XM_006716267.1. [O60504-1]
XP_006716332.1. XM_006716269.1. [O60504-2]
XP_006716333.1. XM_006716270.1. [O60504-2]
XP_006716334.1. XM_006716271.1. [O60504-2]
UniGeneiHs.528572.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CT3NMR-A615-671[»]
2DLMNMR-A383-437[»]
2NWMNMR-A383-438[»]
2YUPNMR-A447-523[»]
ProteinModelPortaliO60504.
SMRiO60504. Positions 354-525, 615-671.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115475. 52 interactions.
IntActiO60504. 31 interactions.
MINTiMINT-262486.
STRINGi9606.ENSP00000240123.

PTM databases

PhosphoSiteiO60504.

Proteomic databases

MaxQBiO60504.
PaxDbiO60504.
PRIDEiO60504.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240123; ENSP00000240123; ENSG00000120896. [O60504-1]
GeneIDi10174.
KEGGihsa:10174.
UCSCiuc003xbv.3. human. [O60504-1]
uc003xbw.4. human. [O60504-2]

Organism-specific databases

CTDi10174.
GeneCardsiGC08P022409.
H-InvDBHIX0201306.
HGNCiHGNC:30907. SORBS3.
HPAiHPA015849.
HPA048034.
MIMi610795. gene.
neXtProtiNX_O60504.
PharmGKBiPA128394570.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG256936.
GeneTreeiENSGT00760000119190.
HOGENOMiHOG000294090.
HOVERGENiHBG054842.
InParanoidiO60504.
OMAiHWTPYRA.
OrthoDBiEOG7WX08W.
PhylomeDBiO60504.
TreeFamiTF320680.

Enzyme and pathway databases

ReactomeiREACT_20558. Smooth Muscle Contraction.
SignaLinkiO60504.

Miscellaneous databases

ChiTaRSiSORBS3. human.
EvolutionaryTraceiO60504.
GeneWikiiSORBS3.
GenomeRNAii10174.
NextBioi38520.
PROiO60504.
SOURCEiSearch...

Gene expression databases

BgeeiO60504.
CleanExiHS_SORBS3.
ExpressionAtlasiO60504. baseline and differential.
GenevestigatoriO60504.

Family and domain databases

InterProiIPR001452. SH3_domain.
IPR003127. Sorb.
IPR028510. Vinexin.
[Graphical view]
PANTHERiPTHR10661:SF68. PTHR10661:SF68. 1 hit.
PfamiPF00018. SH3_1. 1 hit.
PF14604. SH3_9. 2 hits.
PF02208. Sorb. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 3 hits.
SM00459. Sorb. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 3 hits.
PROSITEiPS50002. SH3. 3 hits.
PS50831. SOHO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization."
    Kioka N., Sakata S., Kawauchi T., Amachi T., Akiyama S.K., Okazaki K., Yaen C., Yamada K.M., Aota S.
    J. Cell Biol. 144:59-69(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA), ALTERNATIVE SPLICING, MUTAGENESIS, VARIANT THR-556.
    Tissue: Placenta.
  2. Her J.-H., Gorman D., Miyajima A., Bolen J.B.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA), VARIANT THR-556.
  3. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-556.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS ALPHA AND BETA), VARIANT THR-556.
    Tissue: PNS and Uterus.
  6. "Vinexin forms a signaling complex with Sos and modulates epidermal growth factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activities."
    Akamatsu M., Aota S., Suwa A., Ueda K., Amachi T., Yamada K.M., Akiyama S.K., Kioka N.
    J. Biol. Chem. 274:35933-35937(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SOS.
  7. "SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor."
    Townson S.M., Dobrzycka K.M., Lee A.V., Air M., Deng W., Kang K., Jiang S., Kioka N., Michaelis K., Oesterreich S.
    J. Biol. Chem. 278:20059-20068(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SAFB2.
  8. "The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin."
    Martens N., Wery M., Wang P., Braet F., Gertler A., Hooghe R., Vandenhaute J., Hooghe-Peters E.L.
    Exp. Cell Res. 298:239-248(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SOCS7.
  9. Cited for: INTERACTION WITH INPPL1.
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-530, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Characterization of a multidomain adaptor protein, p140Cap, as part of a pre-synaptic complex."
    Ito H., Atsuzawa K., Sudo K., Di Stefano P., Iwamoto I., Morishita R., Takei S., Semba R., Defilippi P., Asano T., Usuda N., Nagata K.
    J. Neurochem. 107:61-72(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SRCIN1.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-530; SER-551 AND SER-563, VARIANT [LARGE SCALE ANALYSIS] THR-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
    Voss M., Lettau M., Janssen O.
    BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FASLG.
  15. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 (ISOFORM BETA), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6 (ISOFORM BETA), VARIANT [LARGE SCALE ANALYSIS] THR-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS] (ISOFORM BETA).
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-530 AND SER-563, VARIANT [LARGE SCALE ANALYSIS] THR-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 (ISOFORM BETA), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-395; SER-530; SER-545; SER-551 AND SER-563, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6 (ISOFORM BETA), VARIANT [LARGE SCALE ANALYSIS] THR-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS] (ISOFORM BETA).
    Tissue: Cervix carcinoma.
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-544; SER-545 AND SER-563, VARIANT [LARGE SCALE ANALYSIS] THR-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 (ISOFORM BETA), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS] (ISOFORM BETA).
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-348; SER-530; SER-547 AND SER-551, VARIANT [LARGE SCALE ANALYSIS] THR-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  21. "Solution structure of SH3 domains of human vinexin."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 383-437 AND 615-671.
  22. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  23. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  24. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiVINEX_HUMAN
AccessioniPrimary (citable) accession number: O60504
Secondary accession number(s): Q5BJE4
, Q6NX54, Q96FY4, Q9UQE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 11, 2011
Last modified: March 4, 2015
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.