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O60504

- VINEX_HUMAN

UniProt

O60504 - VINEX_HUMAN

Protein

Vinexin

Gene

SORBS3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 148 (01 Oct 2014)
      Sequence version 2 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. structural constituent of cytoskeleton Source: ProtInc
    3. vinculin binding Source: UniProtKB

    GO - Biological processi

    1. actin filament organization Source: InterPro
    2. cell adhesion Source: ProtInc
    3. cell-substrate adhesion Source: Ensembl
    4. muscle contraction Source: Reactome
    5. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    6. positive regulation of cytoskeleton organization Source: UniProtKB
    7. positive regulation of MAPK cascade Source: Ensembl
    8. positive regulation of stress fiber assembly Source: UniProtKB

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_20558. Smooth Muscle Contraction.
    SignaLinkiO60504.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vinexin
    Alternative name(s):
    SH3-containing adapter molecule 1
    Short name:
    SCAM-1
    Sorbin and SH3 domain-containing protein 3
    Gene namesi
    Name:SORBS3
    Synonyms:SCAM1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:30907. SORBS3.

    Subcellular locationi

    Isoform Alpha : Cell junction By similarity. Cytoplasmcytoskeleton By similarity
    Note: Localized at cell-extracellular matrix junctions By similarity. Both isoforms were localized at focal adhesion and cell-cell adhesion sites.By similarity
    Isoform Beta : Cell junction By similarity. Nucleus. Cytoplasmcytoskeleton By similarity
    Note: Localized at cell-extracellular matrix junctions By similarity. Both isoforms were localized at focal adhesion and cell-cell adhesion sites, vinexin beta was also found in the nucleus.By similarity

    GO - Cellular componenti

    1. cytoskeleton Source: UniProtKB-SubCell
    2. cytosol Source: Reactome
    3. focal adhesion Source: Ensembl
    4. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasm, Cytoskeleton, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi649 – 6491W → F: Loss of SOS-binding ability. 1 Publication
    Mutagenesisi667 – 6671Y → V: Loss of SOS-binding ability. 1 Publication

    Organism-specific databases

    PharmGKBiPA128394570.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 671671VinexinPRO_0000065830Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei348 – 3481Phosphoserine2 Publications
    Modified residuei395 – 3951Phosphoserine1 Publication
    Modified residuei530 – 5301Phosphoserine; by MAPK14 Publications
    Modified residuei544 – 5441Phosphoserine1 Publication
    Modified residuei545 – 5451Phosphoserine2 Publications
    Modified residuei551 – 5511Phosphoserine2 Publications
    Modified residuei563 – 5631Phosphoserine4 Publications

    Post-translational modificationi

    Phosphorylated at Ser-530 by MAPK1/ERK2 during cell spreading.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO60504.
    PaxDbiO60504.
    PRIDEiO60504.

    PTM databases

    PhosphoSiteiO60504.

    Expressioni

    Tissue specificityi

    Both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform beta is especially found in liver.

    Gene expression databases

    ArrayExpressiO60504.
    BgeeiO60504.
    CleanExiHS_SORBS3.
    GenevestigatoriO60504.

    Organism-specific databases

    HPAiHPA015849.
    HPA048034.

    Interactioni

    Subunit structurei

    Interacts with DLG5 through its third SH3 domain By similarity. Interacts with vinculin by the first two SH3 domains and the proline rich region of vinculin. Binds to SOS (guanine nucleotide exchange factor of RAS and RAC), through its third SH3 domain. The formation of this complex is down-regulated by phosphorylation of SOS. Interacts with INPPL1/SHIP2, SAFB2, SOCS7 and SRCIN1. Interacts with FASLG. Interacts with MAPK1/ERK2 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ABL1P005195EBI-1222956,EBI-375543
    INPPL1O153572EBI-1222953,EBI-1384248
    PAK2Q131773EBI-741237,EBI-1045887
    RARGP136312EBI-1222956,EBI-2568901
    RTKNQ9BST93EBI-741237,EBI-446694
    SAFB2Q141513EBI-1222956,EBI-352869
    Srcin1Q9QWI6-24EBI-1222956,EBI-775607From a different organism.
    WASF2Q9Y6W53EBI-1222956,EBI-4290615
    WASLO004013EBI-1222956,EBI-957615

    Protein-protein interaction databases

    BioGridi115475. 30 interactions.
    IntActiO60504. 30 interactions.
    MINTiMINT-262486.
    STRINGi9606.ENSP00000240123.

    Structurei

    Secondary structure

    1
    671
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi385 – 3895
    Beta strandi395 – 3984
    Beta strandi406 – 4149
    Beta strandi417 – 4226
    Beta strandi425 – 43511
    Helixi453 – 4553
    Beta strandi456 – 4616
    Beta strandi469 – 4724
    Beta strandi480 – 4856
    Beta strandi489 – 4957
    Turni497 – 4993
    Beta strandi502 – 5065
    Helixi507 – 5093
    Beta strandi510 – 5145
    Beta strandi615 – 6217
    Beta strandi637 – 6448
    Beta strandi646 – 6483
    Beta strandi650 – 6578
    Beta strandi660 – 6634
    Turni665 – 6673
    Beta strandi668 – 6703

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CT3NMR-A615-671[»]
    2DLMNMR-A383-437[»]
    2NWMNMR-A383-438[»]
    2YUPNMR-A447-523[»]
    ProteinModelPortaliO60504.
    SMRiO60504. Positions 354-525, 615-671.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO60504.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini115 – 18773SoHoPROSITE-ProRule annotationAdd
    BLAST
    Domaini380 – 43960SH3 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini454 – 51562SH3 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini612 – 67160SH3 3PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni380 – 515136Binds to vinculinAdd
    BLAST
    Regioni612 – 67160Binds to SOSAdd
    BLAST

    Sequence similaritiesi

    Contains 3 SH3 domains.PROSITE-ProRule annotation
    Contains 1 SoHo domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiNOG256936.
    HOGENOMiHOG000294090.
    HOVERGENiHBG054842.
    InParanoidiO60504.
    OMAiHWTPYRA.
    OrthoDBiEOG7WX08W.
    PhylomeDBiO60504.
    TreeFamiTF320680.

    Family and domain databases

    InterProiIPR001452. SH3_domain.
    IPR003127. Sorb.
    IPR028510. Vinexin.
    [Graphical view]
    PANTHERiPTHR10661:SF68. PTHR10661:SF68. 1 hit.
    PfamiPF00018. SH3_1. 1 hit.
    PF14604. SH3_9. 2 hits.
    PF02208. Sorb. 1 hit.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    SMARTiSM00326. SH3. 3 hits.
    SM00459. Sorb. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 3 hits.
    PROSITEiPS50002. SH3. 3 hits.
    PS50831. SOHO. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Alpha (identifier: O60504-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQGPPRSLRA GLSLDDFIPG HLQSHIGSSS RGTRVPVIRN GGSNTLNFQF    50
    HDPAPRTVCN GGYTPRRDAS QHPDPAWYQT WPGPGSKPSA STKIPASQHT 100
    QNWSATWTKD SKRRDKRWVK YEGIGPVDES GMPIAPRSSV DRPRDWYRRM 150
    FQQIHRKMPD LQLDWTFEEP PRDPRHLGAQ QRPAHRPGPA TSSSGRSWDH 200
    SEELPRSTFN YRPGAFSTVL QPSNQVLRRR EKVDNVWTEE SWNQFLQELE 250
    TGQRPKKPLV DDPGEKPSQP IEVLLERELA ELSAELDKDL RAIETRLPSP 300
    KSSPAPRRAP EQRPPAGPAS AWSSSYPHAP YLGSARSLSP HKMADGGSPF 350
    LGRRDFVYPS STRDPSASNG GGSPARREEK KRKAARLKFD FQAQSPKELT 400
    LQKGDIVYIH KEVDKNWLEG EHHGRLGIFP ANYVEVLPAD EIPKPIKPPT 450
    YQVLEYGEAV AQYTFKGDLE VELSFRKGEH ICLIRKVNEN WYEGRITGTG 500
    RQGIFPASYV QVSREPRLRL CDDGPQLPTS PRLTAAARSA RHPSSPSALR 550
    SPADPIDLGG QTSPRRTGFS FPTQEPRPQT QNLGTPGPAL SHSRGPSHPL 600
    DLGTSSPNTS QIHWTPYRAM YQYRPQNEDE LELREGDRVD VMQQCDDGWF 650
    VGVSRRTQKF GTFPGNYVAP V 671
    Length:671
    Mass (Da):75,341
    Last modified:January 11, 2011 - v2
    Checksum:i2D8A8718E0367BE9
    GO
    Isoform Beta (identifier: O60504-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-342: Missing.

    Show »
    Length:329
    Mass (Da):36,742
    Checksum:i852B1FDC07859AC2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti583 – 5831L → F in AAD32304. (PubMed:9885244)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti255 – 2551P → L.
    Corresponds to variant rs3758036 [ dbSNP | Ensembl ].
    VAR_057019
    Natural varianti556 – 5561I → T.12 Publications
    Corresponds to variant rs2449331 [ dbSNP | Ensembl ].
    VAR_055019
    Natural varianti573 – 5731T → A.
    Corresponds to variant rs1047030 [ dbSNP | Ensembl ].
    VAR_055020

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 342342Missing in isoform Beta. 2 PublicationsVSP_004489Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF064807 mRNA. Translation: AAD32304.1.
    AF037261 mRNA. Translation: AAC09244.1.
    AC037459 Genomic DNA. No translation available.
    CH471080 Genomic DNA. Translation: EAW63675.1.
    BC067260 mRNA. Translation: AAH67260.2.
    BC091514 mRNA. Translation: AAH91514.1.
    BC010146 mRNA. Translation: AAH10146.1.
    CCDSiCCDS47824.1. [O60504-2]
    CCDS6031.1. [O60504-1]
    RefSeqiNP_001018003.1. NM_001018003.2. [O60504-2]
    NP_005766.3. NM_005775.4. [O60504-1]
    XP_005273428.1. XM_005273371.1. [O60504-2]
    XP_006716330.1. XM_006716267.1. [O60504-1]
    XP_006716332.1. XM_006716269.1. [O60504-2]
    XP_006716333.1. XM_006716270.1. [O60504-2]
    XP_006716334.1. XM_006716271.1. [O60504-2]
    UniGeneiHs.528572.

    Genome annotation databases

    EnsembliENST00000240123; ENSP00000240123; ENSG00000120896. [O60504-1]
    GeneIDi10174.
    KEGGihsa:10174.
    UCSCiuc003xbv.3. human. [O60504-1]
    uc003xbw.4. human. [O60504-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF064807 mRNA. Translation: AAD32304.1 .
    AF037261 mRNA. Translation: AAC09244.1 .
    AC037459 Genomic DNA. No translation available.
    CH471080 Genomic DNA. Translation: EAW63675.1 .
    BC067260 mRNA. Translation: AAH67260.2 .
    BC091514 mRNA. Translation: AAH91514.1 .
    BC010146 mRNA. Translation: AAH10146.1 .
    CCDSi CCDS47824.1. [O60504-2 ]
    CCDS6031.1. [O60504-1 ]
    RefSeqi NP_001018003.1. NM_001018003.2. [O60504-2 ]
    NP_005766.3. NM_005775.4. [O60504-1 ]
    XP_005273428.1. XM_005273371.1. [O60504-2 ]
    XP_006716330.1. XM_006716267.1. [O60504-1 ]
    XP_006716332.1. XM_006716269.1. [O60504-2 ]
    XP_006716333.1. XM_006716270.1. [O60504-2 ]
    XP_006716334.1. XM_006716271.1. [O60504-2 ]
    UniGenei Hs.528572.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CT3 NMR - A 615-671 [» ]
    2DLM NMR - A 383-437 [» ]
    2NWM NMR - A 383-438 [» ]
    2YUP NMR - A 447-523 [» ]
    ProteinModelPortali O60504.
    SMRi O60504. Positions 354-525, 615-671.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115475. 30 interactions.
    IntActi O60504. 30 interactions.
    MINTi MINT-262486.
    STRINGi 9606.ENSP00000240123.

    PTM databases

    PhosphoSitei O60504.

    Proteomic databases

    MaxQBi O60504.
    PaxDbi O60504.
    PRIDEi O60504.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000240123 ; ENSP00000240123 ; ENSG00000120896 . [O60504-1 ]
    GeneIDi 10174.
    KEGGi hsa:10174.
    UCSCi uc003xbv.3. human. [O60504-1 ]
    uc003xbw.4. human. [O60504-2 ]

    Organism-specific databases

    CTDi 10174.
    GeneCardsi GC08P022409.
    H-InvDB HIX0201306.
    HGNCi HGNC:30907. SORBS3.
    HPAi HPA015849.
    HPA048034.
    MIMi 610795. gene.
    neXtProti NX_O60504.
    PharmGKBi PA128394570.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG256936.
    HOGENOMi HOG000294090.
    HOVERGENi HBG054842.
    InParanoidi O60504.
    OMAi HWTPYRA.
    OrthoDBi EOG7WX08W.
    PhylomeDBi O60504.
    TreeFami TF320680.

    Enzyme and pathway databases

    Reactomei REACT_20558. Smooth Muscle Contraction.
    SignaLinki O60504.

    Miscellaneous databases

    ChiTaRSi SORBS3. human.
    EvolutionaryTracei O60504.
    GeneWikii SORBS3.
    GenomeRNAii 10174.
    NextBioi 38520.
    PROi O60504.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60504.
    Bgeei O60504.
    CleanExi HS_SORBS3.
    Genevestigatori O60504.

    Family and domain databases

    InterProi IPR001452. SH3_domain.
    IPR003127. Sorb.
    IPR028510. Vinexin.
    [Graphical view ]
    PANTHERi PTHR10661:SF68. PTHR10661:SF68. 1 hit.
    Pfami PF00018. SH3_1. 1 hit.
    PF14604. SH3_9. 2 hits.
    PF02208. Sorb. 1 hit.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    SMARTi SM00326. SH3. 3 hits.
    SM00459. Sorb. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 3 hits.
    PROSITEi PS50002. SH3. 3 hits.
    PS50831. SOHO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization."
      Kioka N., Sakata S., Kawauchi T., Amachi T., Akiyama S.K., Okazaki K., Yaen C., Yamada K.M., Aota S.
      J. Cell Biol. 144:59-69(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA), ALTERNATIVE SPLICING, MUTAGENESIS, VARIANT THR-556.
      Tissue: Placenta.
    2. Her J.-H., Gorman D., Miyajima A., Bolen J.B.
      Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA), VARIANT THR-556.
    3. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-556.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS ALPHA AND BETA), VARIANT THR-556.
      Tissue: PNS and Uterus.
    6. "Vinexin forms a signaling complex with Sos and modulates epidermal growth factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activities."
      Akamatsu M., Aota S., Suwa A., Ueda K., Amachi T., Yamada K.M., Akiyama S.K., Kioka N.
      J. Biol. Chem. 274:35933-35937(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SOS.
    7. "SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor."
      Townson S.M., Dobrzycka K.M., Lee A.V., Air M., Deng W., Kang K., Jiang S., Kioka N., Michaelis K., Oesterreich S.
      J. Biol. Chem. 278:20059-20068(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SAFB2.
    8. "The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin."
      Martens N., Wery M., Wang P., Braet F., Gertler A., Hooghe R., Vandenhaute J., Hooghe-Peters E.L.
      Exp. Cell Res. 298:239-248(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SOCS7.
    9. Cited for: INTERACTION WITH INPPL1.
    10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-530, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Characterization of a multidomain adaptor protein, p140Cap, as part of a pre-synaptic complex."
      Ito H., Atsuzawa K., Sudo K., Di Stefano P., Iwamoto I., Morishita R., Takei S., Semba R., Defilippi P., Asano T., Usuda N., Nagata K.
      J. Neurochem. 107:61-72(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SRCIN1.
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-530; SER-551 AND SER-563, VARIANT [LARGE SCALE ANALYSIS] THR-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
      Voss M., Lettau M., Janssen O.
      BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FASLG.
    15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-348, VARIANT [LARGE SCALE ANALYSIS] THR-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-530 AND SER-563, VARIANT [LARGE SCALE ANALYSIS] THR-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-348; SER-395; SER-530; SER-545; SER-551 AND SER-563, VARIANT [LARGE SCALE ANALYSIS] THR-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-544; SER-545 AND SER-563, VARIANT [LARGE SCALE ANALYSIS] THR-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    20. "Solution structure of SH3 domains of human vinexin."
      RIKEN structural genomics initiative (RSGI)
      Submitted (OCT-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 383-437 AND 615-671.
    21. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    22. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    23. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiVINEX_HUMAN
    AccessioniPrimary (citable) accession number: O60504
    Secondary accession number(s): Q5BJE4
    , Q6NX54, Q96FY4, Q9UQE4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 148 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3