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Protein

Vinexin

Gene

SORBS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.

GO - Molecular functioni

  • structural constituent of cytoskeleton Source: ProtInc
  • transcription factor binding Source: Ensembl
  • vinculin binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-445355 Smooth Muscle Contraction
SignaLinkiO60504
SIGNORiO60504

Names & Taxonomyi

Protein namesi
Recommended name:
Vinexin
Alternative name(s):
SH3-containing adapter molecule 1
Short name:
SCAM-1
Sorbin and SH3 domain-containing protein 3
Gene namesi
Name:SORBS3
Synonyms:SCAM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000120896.13
HGNCiHGNC:30907 SORBS3
MIMi610795 gene
neXtProtiNX_O60504

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi649W → F: Loss of SOS-binding ability. 1 Publication1
Mutagenesisi667Y → V: Loss of SOS-binding ability. 1 Publication1

Organism-specific databases

DisGeNETi10174
OpenTargetsiENSG00000120896
PharmGKBiPA128394570

Polymorphism and mutation databases

BioMutaiSORBS3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000658301 – 671VinexinAdd BLAST671
Isoform Beta (identifier: O60504-2)
Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei348PhosphoserineCombined sources1
Modified residuei395PhosphoserineCombined sources1
Modified residuei530Phosphoserine; by MAPK1Combined sources1
Modified residuei544PhosphoserineCombined sources1
Modified residuei545PhosphoserineCombined sources1
Modified residuei547PhosphoserineCombined sources1
Modified residuei551PhosphoserineCombined sources1
Modified residuei563PhosphoserineCombined sources1
Isoform Beta (identifier: O60504-2)
Modified residuei2N-acetylalanineCombined sources1
Modified residuei6PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated at Ser-530 by MAPK1/ERK2 during cell spreading.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO60504
MaxQBiO60504
PaxDbiO60504
PeptideAtlasiO60504
PRIDEiO60504
ProteomicsDBi49442
49443 [O60504-2]

PTM databases

iPTMnetiO60504
PhosphoSitePlusiO60504

Expressioni

Tissue specificityi

Both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform beta is especially found in liver.

Gene expression databases

BgeeiENSG00000120896
CleanExiHS_SORBS3
ExpressionAtlasiO60504 baseline and differential
GenevisibleiO60504 HS

Organism-specific databases

HPAiHPA015849
HPA048034

Interactioni

Subunit structurei

Interacts with DLG5 through its third SH3 domain (By similarity). Interacts with vinculin by the first two SH3 domains and the proline rich region of vinculin. Binds to SOS (guanine nucleotide exchange factor of RAS and RAC), through its third SH3 domain. The formation of this complex is down-regulated by phosphorylation of SOS. Interacts with INPPL1/SHIP2, SAFB2, SOCS7 and SRCIN1. Interacts with FASLG. Interacts with MAPK1/ERK2 (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • transcription factor binding Source: Ensembl
  • vinculin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115475, 65 interactors
CORUMiO60504
IntActiO60504, 149 interactors
MINTiO60504
STRINGi9606.ENSP00000240123

Structurei

Secondary structure

1671
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi385 – 389Combined sources5
Beta strandi395 – 398Combined sources4
Beta strandi406 – 414Combined sources9
Beta strandi417 – 422Combined sources6
Beta strandi425 – 435Combined sources11
Helixi453 – 455Combined sources3
Beta strandi456 – 461Combined sources6
Beta strandi469 – 472Combined sources4
Beta strandi480 – 485Combined sources6
Beta strandi489 – 495Combined sources7
Turni497 – 499Combined sources3
Beta strandi502 – 506Combined sources5
Helixi507 – 509Combined sources3
Beta strandi510 – 514Combined sources5
Beta strandi615 – 621Combined sources7
Beta strandi637 – 644Combined sources8
Beta strandi646 – 648Combined sources3
Beta strandi650 – 657Combined sources8
Beta strandi660 – 663Combined sources4
Turni665 – 667Combined sources3
Beta strandi668 – 670Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CT3NMR-A615-671[»]
2DLMNMR-A383-437[»]
2NWMNMR-A383-438[»]
2YUPNMR-A447-523[»]
ProteinModelPortaliO60504
SMRiO60504
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60504

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini115 – 187SoHoPROSITE-ProRule annotationAdd BLAST73
Domaini380 – 439SH3 1PROSITE-ProRule annotationAdd BLAST60
Domaini454 – 515SH3 2PROSITE-ProRule annotationAdd BLAST62
Domaini612 – 671SH3 3PROSITE-ProRule annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni380 – 515Binds to vinculinAdd BLAST136
Regioni612 – 671Binds to SOSAdd BLAST60

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiENOG410IPNP Eukaryota
ENOG410XP8Q LUCA
GeneTreeiENSGT00760000119190
HOGENOMiHOG000294090
HOVERGENiHBG054842
InParanoidiO60504
OMAiNTLNFQF
OrthoDBiEOG091G039F
PhylomeDBiO60504
TreeFamiTF320680

Family and domain databases

CDDicd11921 SH3_Vinexin_1, 1 hit
cd11924 SH3_Vinexin_2, 1 hit
cd11918 SH3_Vinexin_3, 1 hit
InterProiView protein in InterPro
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR003127 SoHo_dom
IPR028510 Vinexin
IPR035609 Vinexin_SH3_1
IPR035608 Vinexin_SH3_2
IPR035607 Vinexin_SH3_3
PANTHERiPTHR44972 PTHR44972, 1 hit
PfamiView protein in Pfam
PF00018 SH3_1, 1 hit
PF14604 SH3_9, 2 hits
PF02208 Sorb, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00326 SH3, 3 hits
SM00459 Sorb, 1 hit
SUPFAMiSSF50044 SSF50044, 3 hits
PROSITEiView protein in PROSITE
PS50002 SH3, 3 hits
PS50831 SOHO, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Alpha (identifier: O60504-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQGPPRSLRA GLSLDDFIPG HLQSHIGSSS RGTRVPVIRN GGSNTLNFQF
60 70 80 90 100
HDPAPRTVCN GGYTPRRDAS QHPDPAWYQT WPGPGSKPSA STKIPASQHT
110 120 130 140 150
QNWSATWTKD SKRRDKRWVK YEGIGPVDES GMPIAPRSSV DRPRDWYRRM
160 170 180 190 200
FQQIHRKMPD LQLDWTFEEP PRDPRHLGAQ QRPAHRPGPA TSSSGRSWDH
210 220 230 240 250
SEELPRSTFN YRPGAFSTVL QPSNQVLRRR EKVDNVWTEE SWNQFLQELE
260 270 280 290 300
TGQRPKKPLV DDPGEKPSQP IEVLLERELA ELSAELDKDL RAIETRLPSP
310 320 330 340 350
KSSPAPRRAP EQRPPAGPAS AWSSSYPHAP YLGSARSLSP HKMADGGSPF
360 370 380 390 400
LGRRDFVYPS STRDPSASNG GGSPARREEK KRKAARLKFD FQAQSPKELT
410 420 430 440 450
LQKGDIVYIH KEVDKNWLEG EHHGRLGIFP ANYVEVLPAD EIPKPIKPPT
460 470 480 490 500
YQVLEYGEAV AQYTFKGDLE VELSFRKGEH ICLIRKVNEN WYEGRITGTG
510 520 530 540 550
RQGIFPASYV QVSREPRLRL CDDGPQLPTS PRLTAAARSA RHPSSPSALR
560 570 580 590 600
SPADPIDLGG QTSPRRTGFS FPTQEPRPQT QNLGTPGPAL SHSRGPSHPL
610 620 630 640 650
DLGTSSPNTS QIHWTPYRAM YQYRPQNEDE LELREGDRVD VMQQCDDGWF
660 670
VGVSRRTQKF GTFPGNYVAP V
Length:671
Mass (Da):75,341
Last modified:January 11, 2011 - v2
Checksum:i2D8A8718E0367BE9
GO
Isoform Beta (identifier: O60504-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-342: Missing.

Show »
Length:329
Mass (Da):36,742
Checksum:i852B1FDC07859AC2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti583L → F in AAD32304 (PubMed:9885244).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057019255P → L. Corresponds to variant dbSNP:rs3758036Ensembl.1
Natural variantiVAR_055019556I → TCombined sources4 PublicationsCorresponds to variant dbSNP:rs2449331Ensembl.1
Natural variantiVAR_055020573T → A. Corresponds to variant dbSNP:rs1047030Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0044891 – 342Missing in isoform Beta. 2 PublicationsAdd BLAST342

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064807 mRNA Translation: AAD32304.1
AF037261 mRNA Translation: AAC09244.1
AC037459 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63675.1
BC067260 mRNA Translation: AAH67260.2
BC091514 mRNA Translation: AAH91514.1
BC010146 mRNA Translation: AAH10146.1
CCDSiCCDS47824.1 [O60504-2]
CCDS6031.1 [O60504-1]
RefSeqiNP_001018003.1, NM_001018003.2 [O60504-2]
NP_005766.3, NM_005775.4 [O60504-1]
XP_005273428.1, XM_005273371.1 [O60504-2]
XP_016868433.1, XM_017012944.1 [O60504-2]
XP_016868434.1, XM_017012945.1 [O60504-2]
XP_016868435.1, XM_017012946.1 [O60504-2]
UniGeneiHs.528572

Genome annotation databases

EnsembliENST00000240123; ENSP00000240123; ENSG00000120896 [O60504-1]
ENST00000523965; ENSP00000429764; ENSG00000120896 [O60504-2]
GeneIDi10174
KEGGihsa:10174
UCSCiuc003xbv.4 human [O60504-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiVINEX_HUMAN
AccessioniPrimary (citable) accession number: O60504
Secondary accession number(s): Q5BJE4
, Q6NX54, Q96FY4, Q9UQE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 11, 2011
Last modified: June 20, 2018
This is version 184 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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