Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O60503

- ADCY9_HUMAN

UniProt

O60503 - ADCY9_HUMAN

Protein

Adenylate cyclase type 9

Gene

ADCY9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 4 (13 Dec 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin By similarity.By similarity

    Catalytic activityi

    ATP = 3',5'-cyclic AMP + diphosphate.

    Cofactori

    Binds 2 magnesium ions per subunit.

    Enzyme regulationi

    Insensitive to calcium/calmodulin, forskolin and somatostatin. Stimulated by beta-adrenergic receptor activation.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi399 – 3991Magnesium 1PROSITE-ProRule annotation
    Metal bindingi399 – 3991Magnesium 2PROSITE-ProRule annotation
    Metal bindingi400 – 4001Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation
    Metal bindingi443 – 4431Magnesium 1PROSITE-ProRule annotation
    Metal bindingi443 – 4431Magnesium 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. adenylate cyclase activity Source: ProtInc
    2. ATP binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. activation of phospholipase C activity Source: Reactome
    2. activation of protein kinase A activity Source: Reactome
    3. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Reactome
    4. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Reactome
    5. cellular response to glucagon stimulus Source: Reactome
    6. energy reserve metabolic process Source: Reactome
    7. epidermal growth factor receptor signaling pathway Source: Reactome
    8. fibroblast growth factor receptor signaling pathway Source: Reactome
    9. innate immune response Source: Reactome
    10. intracellular signal transduction Source: InterPro
    11. neurotrophin TRK receptor signaling pathway Source: Reactome
    12. signal transduction Source: Reactome
    13. small molecule metabolic process Source: Reactome
    14. synaptic transmission Source: Reactome
    15. transmembrane transport Source: Reactome
    16. water transport Source: Reactome

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    cAMP biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_15312. Adenylate cyclase activating pathway.
    REACT_15333. Adenylate cyclase inhibitory pathway.
    REACT_15530. PKA activation.
    REACT_1665. Glucagon signaling in metabolic regulation.
    REACT_19231. G alpha (i) signalling events.
    REACT_19327. G alpha (s) signalling events.
    REACT_19333. G alpha (z) signalling events.
    REACT_1946. PKA activation in glucagon signalling.
    REACT_24023. Regulation of water balance by renal Aquaporins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate cyclase type 9 (EC:4.6.1.1)
    Alternative name(s):
    ATP pyrophosphate-lyase 9
    Adenylate cyclase type IX
    Adenylyl cyclase 9
    Gene namesi
    Name:ADCY9
    Synonyms:KIAA0520
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:240. ADCY9.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. dendrite Source: Ensembl
    3. integral component of plasma membrane Source: ProtInc
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13531353Adenylate cyclase type 9PRO_0000195708Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi955 – 9551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi964 – 9641N-linked (GlcNAc...)Sequence Analysis
    Modified residuei1259 – 12591Phosphoserine1 Publication
    Modified residuei1307 – 13071Phosphoserine1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiO60503.
    PaxDbiO60503.
    PRIDEiO60503.

    PTM databases

    PhosphoSiteiO60503.

    Expressioni

    Tissue specificityi

    Expressed in multiple cells of the lung, with expression highest in airway smooth muscle.1 Publication

    Gene expression databases

    ArrayExpressiO60503.
    BgeeiO60503.
    CleanExiHS_ADCY9.
    GenevestigatoriO60503.

    Organism-specific databases

    HPAiHPA041328.
    HPA044225.

    Interactioni

    Protein-protein interaction databases

    BioGridi106628. 2 interactions.
    STRINGi9606.ENSP00000294016.

    Structurei

    3D structure databases

    ProteinModelPortaliO60503.
    SMRiO60503. Positions 380-553, 1050-1241.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 117117CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini139 – 1413ExtracellularSequence Analysis
    Topological domaini163 – 1719CytoplasmicSequence Analysis
    Topological domaini193 – 21523ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini236 – 2416CytoplasmicSequence Analysis
    Topological domaini260 – 28021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini302 – 786485CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini808 – 81811ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini840 – 86728CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini889 – 8913ExtracellularSequence Analysis
    Topological domaini913 – 9208CytoplasmicSequence Analysis
    Topological domaini942 – 97534ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini997 – 1353357CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei118 – 13821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei172 – 19221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei216 – 23520HelicalSequence AnalysisAdd
    BLAST
    Transmembranei242 – 25918HelicalSequence AnalysisAdd
    BLAST
    Transmembranei281 – 30121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei787 – 80721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei819 – 83921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei868 – 88821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei892 – 91221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei921 – 94121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei976 – 99621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini394 – 521128Guanylate cyclase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1058 – 1198141Guanylate cyclase 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
    Contains 2 guanylate cyclase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2114.
    HOVERGENiHBG050459.
    InParanoidiO60503.
    KOiK08049.
    OMAiIYFGVHM.
    OrthoDBiEOG7TF78Q.
    PhylomeDBiO60503.
    TreeFamiTF313845.

    Family and domain databases

    Gene3Di3.30.70.1230. 2 hits.
    InterProiIPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    [Graphical view]
    PfamiPF00211. Guanylate_cyc. 2 hits.
    [Graphical view]
    SMARTiSM00044. CYCc. 2 hits.
    [Graphical view]
    SUPFAMiSSF55073. SSF55073. 2 hits.
    PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O60503-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASPPHQQLL HHHSTEVSCD SSGDSNSVRV KINPKQLSSN SHPKHCKYSI     50
    SSSCSSSGDS GGVPRRVGGG GRLRRQKKLP QLFERASSRW WDPKFDSVNL 100
    EEACLERCFP QTQRRFRYAL FYIGFACLLW SIYFAVHMRS RLIVMVAPAL 150
    CFLLVCVGFF LFTFTKLYAR HYAWTSLALT LLVFALTLAA QFQVLTPVSG 200
    RGDSSNLTAT ARPTDTCLSQ VGSFSMCIEV LFLLYTVMHL PLYLSLCLGV 250
    AYSVLFETFG YHFRDEACFP SPGAGALHWE LLSRGLLHGC IHAIGVHLFV 300
    MSQVRSRSTF LKVGQSIMHG KDLEVEKALK ERMIHSVMPR IIADDLMKQG 350
    DEESENSVKR HATSSPKNRK KKSSIQKAPI AFRPFKMQQI EEVSILFADI 400
    VGFTKMSANK SAHALVGLLN DLFGRFDRLC EETKCEKIST LGDCYYCVAG 450
    CPEPRADHAY CCIEMGLGMI KAIEQFCQEK KEMVNMRVGV HTGTVLCGIL 500
    GMRRFKFDVW SNDVNLANLM EQLGVAGKVH ISEATAKYLD DRYEMEDGKV 550
    IERLGQSVVA DQLKGLKTYL ISGQRAKESR CSCAEALLSG FEVIDGSQVS 600
    SGPRGQGTAS SGNVSDLAQT VKTFDNLKTC PSCGITFAPK SEAGAEGGAP 650
    QNGCQDEHKN STKASGGPNP KTQNGLLSPP QEEKLTNSQT SLCEILQEKG 700
    RWAGVSLDQS ALLPLRFKNI REKTDAHFVD VIKEDSLMKD YFFKPPINQF 750
    SLNFLDQELE RSYRTSYQEE VIKNSPVKTF ASPTFSSLLD VFLSTTVFLT 800
    LSTTCFLKYE AATVPPPPAA LAVFSAALLL EVLSLAVSIR MVFFLEDVMA 850
    CTKRLLEWIA GWLPRHCIGA ILVSLPALAV YSHVTSEYET NIHFPVFTGS 900
    AALIAVVHYC NFCQLSSWMR SSLATVVGAG PLLLLYVSLC PDSSVLTSPL 950
    DAVQNFSSER NPCNSSVPRD LRRPASLIGQ EVVLVFFLLL LLVWFLNREF 1000
    EVSYRLHYHG DVEADLHRTK IQSMRDQADW LLRNIIPYHV AEQLKVSQTY 1050
    SKNHDSGGVI FASIVNFSEF YEENYEGGKE CYRVLNELIG DFDELLSKPD 1100
    YSSIEKIKTI GATYMAASGL NTAQAQDGSH PQEHLQILFE FAKEMMRVVD 1150
    DFNNNMLWFN FKLRVGFNHG PLTAGVIGTT KLLYDIWGDT VNIASRMDTT 1200
    GVECRIQVSE ESYRVLSKMG YDFDYRGTVN VKGKGQMKTY LYPKCTDHRV 1250
    IPQHQLSISP DIRVQVDGSI GRSPTDEIAN LVPSVQYVDK TSLGSDSSTQ 1300
    AKDAHLSPKR PWKEPVKAEE RGRFGKAIEK DDCDETGIEE ANELTKLNVS 1350
    KSV 1353
    Length:1,353
    Mass (Da):150,701
    Last modified:December 13, 2002 - v4
    Checksum:i4CBF051EA49B5B7B
    GO

    Sequence cautioni

    The sequence AAC24201.1 differs from that shown. Reason: Frameshift at position 1252.
    The sequence BAA25446.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti493 – 4931G → R in CAB65084. 1 PublicationCurated
    Sequence conflicti884 – 8841V → A in CAB65084. 1 PublicationCurated
    Sequence conflicti1308 – 13081P → R in CAB65084. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti772 – 7721I → M in 37.5% of the Asian population, in 30% of the Caucasian population and in 16.3% of the African-American population; reduced adenylyl cyclase activity in response to stimulation of the beta-adregnergic receptor by the agonists Mn(2+), isoproteronol and NaF; increased albuterol-stimulated adenylyl cyclase activity in the presence of corticosteroid. 2 Publications
    Corresponds to variant rs2230739 [ dbSNP | Ensembl ].
    VAR_023750
    Natural varianti1154 – 11541N → S.3 Publications
    Corresponds to variant rs61731445 [ dbSNP | Ensembl ].
    VAR_070887

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF036927 mRNA. Translation: AAC24201.1. Frameshift.
    DQ008441 mRNA. Translation: AAY27880.1.
    DQ005545 mRNA. Translation: AAY21237.1.
    AJ133123 mRNA. Translation: CAB65084.1.
    AY028959
    , AY028949, AY028950, AY028951, AY028952, AY028953, AY028954, AY028955, AY028956, AY028957 Genomic DNA. Translation: AAK29464.1.
    AB011092 mRNA. Translation: BAA25446.3. Different initiation.
    CH471112 Genomic DNA. Translation: EAW85331.1.
    CH471112 Genomic DNA. Translation: EAW85332.1.
    BC136657 mRNA. Translation: AAI36658.1.
    BC136658 mRNA. Translation: AAI36659.1.
    BC151207 mRNA. Translation: AAI51208.1.
    BC151229 mRNA. Translation: AAI51230.1.
    CCDSiCCDS32382.1.
    RefSeqiNP_001107.2. NM_001116.3.
    UniGeneiHs.391860.
    Hs.610484.

    Genome annotation databases

    EnsembliENST00000294016; ENSP00000294016; ENSG00000162104.
    GeneIDi115.
    KEGGihsa:115.
    UCSCiuc002cvx.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF036927 mRNA. Translation: AAC24201.1 . Frameshift.
    DQ008441 mRNA. Translation: AAY27880.1 .
    DQ005545 mRNA. Translation: AAY21237.1 .
    AJ133123 mRNA. Translation: CAB65084.1 .
    AY028959
    , AY028949 , AY028950 , AY028951 , AY028952 , AY028953 , AY028954 , AY028955 , AY028956 , AY028957 Genomic DNA. Translation: AAK29464.1 .
    AB011092 mRNA. Translation: BAA25446.3 . Different initiation.
    CH471112 Genomic DNA. Translation: EAW85331.1 .
    CH471112 Genomic DNA. Translation: EAW85332.1 .
    BC136657 mRNA. Translation: AAI36658.1 .
    BC136658 mRNA. Translation: AAI36659.1 .
    BC151207 mRNA. Translation: AAI51208.1 .
    BC151229 mRNA. Translation: AAI51230.1 .
    CCDSi CCDS32382.1.
    RefSeqi NP_001107.2. NM_001116.3.
    UniGenei Hs.391860.
    Hs.610484.

    3D structure databases

    ProteinModelPortali O60503.
    SMRi O60503. Positions 380-553, 1050-1241.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106628. 2 interactions.
    STRINGi 9606.ENSP00000294016.

    Chemistry

    BindingDBi O60503.
    ChEMBLi CHEMBL2097167.

    PTM databases

    PhosphoSitei O60503.

    Proteomic databases

    MaxQBi O60503.
    PaxDbi O60503.
    PRIDEi O60503.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000294016 ; ENSP00000294016 ; ENSG00000162104 .
    GeneIDi 115.
    KEGGi hsa:115.
    UCSCi uc002cvx.3. human.

    Organism-specific databases

    CTDi 115.
    GeneCardsi GC16M004003.
    HGNCi HGNC:240. ADCY9.
    HPAi HPA041328.
    HPA044225.
    MIMi 603302. gene.
    neXtProti NX_O60503.
    PharmGKBi PA30.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2114.
    HOVERGENi HBG050459.
    InParanoidi O60503.
    KOi K08049.
    OMAi IYFGVHM.
    OrthoDBi EOG7TF78Q.
    PhylomeDBi O60503.
    TreeFami TF313845.

    Enzyme and pathway databases

    Reactomei REACT_15312. Adenylate cyclase activating pathway.
    REACT_15333. Adenylate cyclase inhibitory pathway.
    REACT_15530. PKA activation.
    REACT_1665. Glucagon signaling in metabolic regulation.
    REACT_19231. G alpha (i) signalling events.
    REACT_19327. G alpha (s) signalling events.
    REACT_19333. G alpha (z) signalling events.
    REACT_1946. PKA activation in glucagon signalling.
    REACT_24023. Regulation of water balance by renal Aquaporins.

    Miscellaneous databases

    ChiTaRSi ADCY9. human.
    GeneWikii ADCY9.
    GenomeRNAii 115.
    NextBioi 35463280.
    PROi O60503.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60503.
    Bgeei O60503.
    CleanExi HS_ADCY9.
    Genevestigatori O60503.

    Family and domain databases

    Gene3Di 3.30.70.1230. 2 hits.
    InterProi IPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    [Graphical view ]
    Pfami PF00211. Guanylate_cyc. 2 hits.
    [Graphical view ]
    SMARTi SM00044. CYCc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55073. SSF55073. 2 hits.
    PROSITEi PS00452. GUANYLATE_CYCLASE_1. 2 hits.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9)."
      Hacker B.M., Tomlinson J.E., Wayman G.A., Sultana R., Chan G., Villacres E., Disteche C., Storm D.R.
      Genomics 50:97-104(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    2. "An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation."
      Small K.M., Brown K.M., Theiss C.T., Seman C.A., Weiss S.T., Liggett S.B.
      Pharmacogenetics 13:535-541(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT MET-772.
    3. "Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways."
      Tantisira K.G., Small K.M., Litonjua A.A., Weiss S.T., Liggett S.B.
      Hum. Mol. Genet. 14:1671-1677(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-772.
    4. "Cloning and characterisation of human adenylyl cyclase IX: differential mRNA regulation and inhibition by Ca2+/calcineurin."
      Paterson J.M., Smith S.M., Simpson J., Grace O.C., Bell J.E., Antoni F.A.
      Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-1154.
    5. "Mutation screening, case control study and transmission disequilibrium analysis of adenylate cyclase type 9 (ADCY9) gene in functional psychoses."
      Toyota T., Yamada K., Meerabux J., Hattori E., Saito K., Yoshitsugu K., Shimizu H., Nankai M., Toru M., Detera-Wadleigh S.D., Yoshikawa T.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-1154.
      Tissue: Brain.
    7. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    8. Ohara O., Nagase T., Kikuno R., Ishikawa K.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-1154.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1259, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1307, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiADCY9_HUMAN
    AccessioniPrimary (citable) accession number: O60503
    Secondary accession number(s): A7E2V5
    , A7E2X2, D3DUD1, O60273, Q4ZHT9, Q4ZIR5, Q9BWT4, Q9UGP2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: December 13, 2002
    Last modified: October 1, 2014
    This is version 130 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3