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Protein

Adenylate cyclase type 9

Gene

ADCY9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity).By similarity

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Mg2+Note: Binds 2 magnesium ions per subunit.

Enzyme regulationi

Insensitive to calcium/calmodulin, forskolin and somatostatin. Stimulated by beta-adrenergic receptor activation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi399 – 3991Magnesium 1PROSITE-ProRule annotation
Metal bindingi399 – 3991Magnesium 2PROSITE-ProRule annotation
Metal bindingi400 – 4001Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi443 – 4431Magnesium 1PROSITE-ProRule annotation
Metal bindingi443 – 4431Magnesium 2PROSITE-ProRule annotation

GO - Molecular functioni

  • adenylate cyclase activity Source: ProtInc
  • ATP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_15312. Adenylate cyclase activating pathway.
REACT_15333. Adenylate cyclase inhibitory pathway.
REACT_15530. PKA activation.
REACT_1665. Glucagon signaling in metabolic regulation.
REACT_19231. G alpha (i) signalling events.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_1946. PKA activation in glucagon signalling.
REACT_24023. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_268323. Hedgehog 'off' state.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase type 9 (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase 9
Adenylate cyclase type IX
Adenylyl cyclase 9
Gene namesi
Name:ADCY9
Synonyms:KIAA0520
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:240. ADCY9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 117117CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei118 – 13821HelicalSequence AnalysisAdd
BLAST
Topological domaini139 – 1413ExtracellularSequence Analysis
Transmembranei142 – 16221HelicalSequence AnalysisAdd
BLAST
Topological domaini163 – 1719CytoplasmicSequence Analysis
Transmembranei172 – 19221HelicalSequence AnalysisAdd
BLAST
Topological domaini193 – 21523ExtracellularSequence AnalysisAdd
BLAST
Transmembranei216 – 23520HelicalSequence AnalysisAdd
BLAST
Topological domaini236 – 2416CytoplasmicSequence Analysis
Transmembranei242 – 25918HelicalSequence AnalysisAdd
BLAST
Topological domaini260 – 28021ExtracellularSequence AnalysisAdd
BLAST
Transmembranei281 – 30121HelicalSequence AnalysisAdd
BLAST
Topological domaini302 – 786485CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei787 – 80721HelicalSequence AnalysisAdd
BLAST
Topological domaini808 – 81811ExtracellularSequence AnalysisAdd
BLAST
Transmembranei819 – 83921HelicalSequence AnalysisAdd
BLAST
Topological domaini840 – 86728CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei868 – 88821HelicalSequence AnalysisAdd
BLAST
Topological domaini889 – 8913ExtracellularSequence Analysis
Transmembranei892 – 91221HelicalSequence AnalysisAdd
BLAST
Topological domaini913 – 9208CytoplasmicSequence Analysis
Transmembranei921 – 94121HelicalSequence AnalysisAdd
BLAST
Topological domaini942 – 97534ExtracellularSequence AnalysisAdd
BLAST
Transmembranei976 – 99621HelicalSequence AnalysisAdd
BLAST
Topological domaini997 – 1353357CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • intracellular Source: GOC
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30.

Polymorphism and mutation databases

BioMutaiADCY9.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13531353Adenylate cyclase type 9PRO_0000195708Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
Modified residuei706 – 7061Phosphoserine1 Publication
Glycosylationi955 – 9551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi964 – 9641N-linked (GlcNAc...)Sequence Analysis
Modified residuei1259 – 12591Phosphoserine1 Publication
Modified residuei1307 – 13071Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO60503.
PaxDbiO60503.
PRIDEiO60503.

PTM databases

PhosphoSiteiO60503.

Expressioni

Tissue specificityi

Expressed in multiple cells of the lung, with expression highest in airway smooth muscle.1 Publication

Gene expression databases

BgeeiO60503.
CleanExiHS_ADCY9.
ExpressionAtlasiO60503. baseline and differential.
GenevisibleiO60503. HS.

Organism-specific databases

HPAiHPA041328.
HPA044225.

Interactioni

Protein-protein interaction databases

BioGridi106628. 8 interactions.
IntActiO60503. 1 interaction.
STRINGi9606.ENSP00000294016.

Structurei

3D structure databases

ProteinModelPortaliO60503.
SMRiO60503. Positions 380-553, 1050-1241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini394 – 521128Guanylate cyclase 1PROSITE-ProRule annotationAdd
BLAST
Domaini1058 – 1198141Guanylate cyclase 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
Contains 2 guanylate cyclase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2114.
GeneTreeiENSGT00760000119042.
HOVERGENiHBG050459.
InParanoidiO60503.
KOiK08049.
OMAiEEHKNST.
OrthoDBiEOG7TF78Q.
PhylomeDBiO60503.
TreeFamiTF313845.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60503-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPPHQQLL HHHSTEVSCD SSGDSNSVRV KINPKQLSSN SHPKHCKYSI
60 70 80 90 100
SSSCSSSGDS GGVPRRVGGG GRLRRQKKLP QLFERASSRW WDPKFDSVNL
110 120 130 140 150
EEACLERCFP QTQRRFRYAL FYIGFACLLW SIYFAVHMRS RLIVMVAPAL
160 170 180 190 200
CFLLVCVGFF LFTFTKLYAR HYAWTSLALT LLVFALTLAA QFQVLTPVSG
210 220 230 240 250
RGDSSNLTAT ARPTDTCLSQ VGSFSMCIEV LFLLYTVMHL PLYLSLCLGV
260 270 280 290 300
AYSVLFETFG YHFRDEACFP SPGAGALHWE LLSRGLLHGC IHAIGVHLFV
310 320 330 340 350
MSQVRSRSTF LKVGQSIMHG KDLEVEKALK ERMIHSVMPR IIADDLMKQG
360 370 380 390 400
DEESENSVKR HATSSPKNRK KKSSIQKAPI AFRPFKMQQI EEVSILFADI
410 420 430 440 450
VGFTKMSANK SAHALVGLLN DLFGRFDRLC EETKCEKIST LGDCYYCVAG
460 470 480 490 500
CPEPRADHAY CCIEMGLGMI KAIEQFCQEK KEMVNMRVGV HTGTVLCGIL
510 520 530 540 550
GMRRFKFDVW SNDVNLANLM EQLGVAGKVH ISEATAKYLD DRYEMEDGKV
560 570 580 590 600
IERLGQSVVA DQLKGLKTYL ISGQRAKESR CSCAEALLSG FEVIDGSQVS
610 620 630 640 650
SGPRGQGTAS SGNVSDLAQT VKTFDNLKTC PSCGITFAPK SEAGAEGGAP
660 670 680 690 700
QNGCQDEHKN STKASGGPNP KTQNGLLSPP QEEKLTNSQT SLCEILQEKG
710 720 730 740 750
RWAGVSLDQS ALLPLRFKNI REKTDAHFVD VIKEDSLMKD YFFKPPINQF
760 770 780 790 800
SLNFLDQELE RSYRTSYQEE VIKNSPVKTF ASPTFSSLLD VFLSTTVFLT
810 820 830 840 850
LSTTCFLKYE AATVPPPPAA LAVFSAALLL EVLSLAVSIR MVFFLEDVMA
860 870 880 890 900
CTKRLLEWIA GWLPRHCIGA ILVSLPALAV YSHVTSEYET NIHFPVFTGS
910 920 930 940 950
AALIAVVHYC NFCQLSSWMR SSLATVVGAG PLLLLYVSLC PDSSVLTSPL
960 970 980 990 1000
DAVQNFSSER NPCNSSVPRD LRRPASLIGQ EVVLVFFLLL LLVWFLNREF
1010 1020 1030 1040 1050
EVSYRLHYHG DVEADLHRTK IQSMRDQADW LLRNIIPYHV AEQLKVSQTY
1060 1070 1080 1090 1100
SKNHDSGGVI FASIVNFSEF YEENYEGGKE CYRVLNELIG DFDELLSKPD
1110 1120 1130 1140 1150
YSSIEKIKTI GATYMAASGL NTAQAQDGSH PQEHLQILFE FAKEMMRVVD
1160 1170 1180 1190 1200
DFNNNMLWFN FKLRVGFNHG PLTAGVIGTT KLLYDIWGDT VNIASRMDTT
1210 1220 1230 1240 1250
GVECRIQVSE ESYRVLSKMG YDFDYRGTVN VKGKGQMKTY LYPKCTDHRV
1260 1270 1280 1290 1300
IPQHQLSISP DIRVQVDGSI GRSPTDEIAN LVPSVQYVDK TSLGSDSSTQ
1310 1320 1330 1340 1350
AKDAHLSPKR PWKEPVKAEE RGRFGKAIEK DDCDETGIEE ANELTKLNVS

KSV
Length:1,353
Mass (Da):150,701
Last modified:December 13, 2002 - v4
Checksum:i4CBF051EA49B5B7B
GO

Sequence cautioni

The sequence AAC24201.1 differs from that shown. Reason: Frameshift at position 1252. Curated
The sequence BAA25446.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti493 – 4931G → R in CAB65084 (Ref. 4) Curated
Sequence conflicti884 – 8841V → A in CAB65084 (Ref. 4) Curated
Sequence conflicti1308 – 13081P → R in CAB65084 (Ref. 4) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti772 – 7721I → M Common polymorphism; found in 37.5% of the Asian population, in 30% of the Caucasian population and in 16.3% of the African-American population; reduced adenylyl cyclase activity in response to stimulation of the beta-adregnergic receptor by Mn(2+) agonists isoproteronol and NaF; increased albuterol-stimulated adenylyl cyclase activity in the presence of corticosteroid. 2 Publications
Corresponds to variant rs2230739 [ dbSNP | Ensembl ].
VAR_023750
Natural varianti1154 – 11541N → S.3 Publications
Corresponds to variant rs61731445 [ dbSNP | Ensembl ].
VAR_070887

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036927 mRNA. Translation: AAC24201.1. Frameshift.
DQ008441 mRNA. Translation: AAY27880.1.
DQ005545 mRNA. Translation: AAY21237.1.
AJ133123 mRNA. Translation: CAB65084.1.
AY028959
, AY028949, AY028950, AY028951, AY028952, AY028953, AY028954, AY028955, AY028956, AY028957 Genomic DNA. Translation: AAK29464.1.
AB011092 mRNA. Translation: BAA25446.3. Different initiation.
CH471112 Genomic DNA. Translation: EAW85331.1.
CH471112 Genomic DNA. Translation: EAW85332.1.
BC136657 mRNA. Translation: AAI36658.1.
BC136658 mRNA. Translation: AAI36659.1.
BC151207 mRNA. Translation: AAI51208.1.
BC151229 mRNA. Translation: AAI51230.1.
CCDSiCCDS32382.1.
RefSeqiNP_001107.2. NM_001116.3.
UniGeneiHs.391860.
Hs.610484.

Genome annotation databases

EnsembliENST00000294016; ENSP00000294016; ENSG00000162104.
GeneIDi115.
KEGGihsa:115.
UCSCiuc002cvx.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036927 mRNA. Translation: AAC24201.1. Frameshift.
DQ008441 mRNA. Translation: AAY27880.1.
DQ005545 mRNA. Translation: AAY21237.1.
AJ133123 mRNA. Translation: CAB65084.1.
AY028959
, AY028949, AY028950, AY028951, AY028952, AY028953, AY028954, AY028955, AY028956, AY028957 Genomic DNA. Translation: AAK29464.1.
AB011092 mRNA. Translation: BAA25446.3. Different initiation.
CH471112 Genomic DNA. Translation: EAW85331.1.
CH471112 Genomic DNA. Translation: EAW85332.1.
BC136657 mRNA. Translation: AAI36658.1.
BC136658 mRNA. Translation: AAI36659.1.
BC151207 mRNA. Translation: AAI51208.1.
BC151229 mRNA. Translation: AAI51230.1.
CCDSiCCDS32382.1.
RefSeqiNP_001107.2. NM_001116.3.
UniGeneiHs.391860.
Hs.610484.

3D structure databases

ProteinModelPortaliO60503.
SMRiO60503. Positions 380-553, 1050-1241.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106628. 8 interactions.
IntActiO60503. 1 interaction.
STRINGi9606.ENSP00000294016.

Chemistry

ChEMBLiCHEMBL2097167.

PTM databases

PhosphoSiteiO60503.

Polymorphism and mutation databases

BioMutaiADCY9.

Proteomic databases

MaxQBiO60503.
PaxDbiO60503.
PRIDEiO60503.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294016; ENSP00000294016; ENSG00000162104.
GeneIDi115.
KEGGihsa:115.
UCSCiuc002cvx.3. human.

Organism-specific databases

CTDi115.
GeneCardsiGC16M004003.
HGNCiHGNC:240. ADCY9.
HPAiHPA041328.
HPA044225.
MIMi603302. gene.
neXtProtiNX_O60503.
PharmGKBiPA30.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2114.
GeneTreeiENSGT00760000119042.
HOVERGENiHBG050459.
InParanoidiO60503.
KOiK08049.
OMAiEEHKNST.
OrthoDBiEOG7TF78Q.
PhylomeDBiO60503.
TreeFamiTF313845.

Enzyme and pathway databases

ReactomeiREACT_15312. Adenylate cyclase activating pathway.
REACT_15333. Adenylate cyclase inhibitory pathway.
REACT_15530. PKA activation.
REACT_1665. Glucagon signaling in metabolic regulation.
REACT_19231. G alpha (i) signalling events.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_1946. PKA activation in glucagon signalling.
REACT_24023. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_268323. Hedgehog 'off' state.

Miscellaneous databases

ChiTaRSiADCY9. human.
GeneWikiiADCY9.
GenomeRNAii115.
NextBioi35463280.
PROiO60503.
SOURCEiSearch...

Gene expression databases

BgeeiO60503.
CleanExiHS_ADCY9.
ExpressionAtlasiO60503. baseline and differential.
GenevisibleiO60503. HS.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9)."
    Hacker B.M., Tomlinson J.E., Wayman G.A., Sultana R., Chan G., Villacres E., Disteche C., Storm D.R.
    Genomics 50:97-104(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation."
    Small K.M., Brown K.M., Theiss C.T., Seman C.A., Weiss S.T., Liggett S.B.
    Pharmacogenetics 13:535-541(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT MET-772.
  3. "Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways."
    Tantisira K.G., Small K.M., Litonjua A.A., Weiss S.T., Liggett S.B.
    Hum. Mol. Genet. 14:1671-1677(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-772.
  4. "Cloning and characterisation of human adenylyl cyclase IX: differential mRNA regulation and inhibition by Ca2+/calcineurin."
    Paterson J.M., Smith S.M., Simpson J., Grace O.C., Bell J.E., Antoni F.A.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-1154.
  5. "Mutation screening, case control study and transmission disequilibrium analysis of adenylate cyclase type 9 (ADCY9) gene in functional psychoses."
    Toyota T., Yamada K., Meerabux J., Hattori E., Saito K., Yoshitsugu K., Shimizu H., Nankai M., Toru M., Detera-Wadleigh S.D., Yoshikawa T.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-1154.
    Tissue: Brain.
  7. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  8. Ohara O., Nagase T., Kikuno R., Ishikawa K.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-1154.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1259, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1307, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-706, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiADCY9_HUMAN
AccessioniPrimary (citable) accession number: O60503
Secondary accession number(s): A7E2V5
, A7E2X2, D3DUD1, O60273, Q4ZHT9, Q4ZIR5, Q9BWT4, Q9UGP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: December 13, 2002
Last modified: July 22, 2015
This is version 138 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.