Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Syntaxin-10

Gene

STX10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.1 Publication

GO - Molecular functioni

  • SNAP receptor activity Source: GO_Central
  • syntaxin binding Source: UniProtKB

GO - Biological processi

  • Golgi vesicle transport Source: InterPro
  • intracellular protein transport Source: GO_Central
  • regulation of protein localization Source: UniProtKB
  • retrograde transport, endosome to Golgi Source: UniProtKB
  • vesicle docking Source: GO_Central
  • vesicle fusion Source: GO_Central

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
SIGNORiO60499

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-10
Short name:
Syn10
Gene namesi
Name:STX10
Synonyms:SYN10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104915.14
HGNCiHGNC:11428 STX10
MIMi603765 gene
neXtProtiNX_O60499

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 228CytoplasmicSequence analysisAdd BLAST227
Transmembranei229 – 249Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104915
PharmGKBiPA36228

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002102202 – 249Syntaxin-10Add BLAST248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei108PhosphoserineCombined sources1
Modified residuei110PhosphothreonineCombined sources1
Modified residuei134PhosphoserineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO60499
MaxQBiO60499
PaxDbiO60499
PeptideAtlasiO60499
PRIDEiO60499
TopDownProteomicsiO60499-1 [O60499-1]

PTM databases

iPTMnetiO60499
PhosphoSitePlusiO60499
SwissPalmiO60499

Miscellaneous databases

PMAP-CutDBO60499

Expressioni

Tissue specificityi

Expressed at high levels in heart, skeletal muscle and pancreas.

Gene expression databases

BgeeiENSG00000104915
CleanExiHS_STX10
ExpressionAtlasiO60499 baseline and differential
GenevisibleiO60499 HS

Organism-specific databases

HPAiHPA035303
HPA056439

Interactioni

Subunit structurei

Interacts with VPS52.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
VPS51Q9UID3-15EBI-16067850,EBI-16067837

GO - Molecular functioni

  • SNAP receptor activity Source: GO_Central
  • syntaxin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114225, 25 interactors
DIPiDIP-60563N
IntActiO60499, 10 interactors
MINTiO60499
STRINGi9606.ENSP00000466298

Structurei

Secondary structure

1249
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 30Combined sources24
Helixi42 – 73Combined sources32
Helixi75 – 78Combined sources4
Helixi82 – 106Combined sources25

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DNDX-ray1.40A1-108[»]
ProteinModelPortaliO60499
SMRiO60499
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini157 – 219t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili41 – 69Sequence analysisAdd BLAST29

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3202 Eukaryota
ENOG410ZZA3 LUCA
GeneTreeiENSGT00390000008991
HOGENOMiHOG000237350
HOVERGENiHBG007194
InParanoidiO60499
KOiK08498
OMAiRWCELLQ
OrthoDBiEOG091G0KE5
PhylomeDBiO60499

Family and domain databases

InterProiView protein in InterPro
IPR010989 SNARE
IPR015260 Syntaxin-6_N
IPR006012 Syntaxin/epimorphin_CS
IPR000727 T_SNARE_dom
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF09177 Syntaxin-6_N, 1 hit
SMARTiView protein in SMART
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60499-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLEDPFFVV RGEVQKAVNT ARGLYQRWCE LLQESAAVGR EELDWTTNEL
60 70 80 90 100
RNGLRSIEWD LEDLEETIGI VEANPGKFKL PAGDLQERKV FVERMREAVQ
110 120 130 140 150
EMKDHMVSPT AVAFLERNNR EILAGKPAAQ KSPSDLLDAS AVSATSRYIE
160 170 180 190 200
EQQATQQLIM DEQDQQLEMV SGSIQVLKHM SGRVGEELDE QGIMLDAFAQ
210 220 230 240
EMDHTQSRMD GVLRKLAKVS HMTSDRRQWC AIAVLVGVLL LVLILLFSL
Length:249
Mass (Da):28,114
Last modified:August 1, 1998 - v1
Checksum:i795AB3055F25AD5F
GO
Isoform 2 (identifier: O60499-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-124: Missing.

Note: No experimental confirmation available.
Show »
Length:200
Mass (Da):22,445
Checksum:iC196F05CCAD78966
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00634776 – 124Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035531 mRNA Translation: AAC05087.1
CR457110 mRNA Translation: CAG33391.1
AC011446 Genomic DNA No translation available.
BC017237 mRNA Translation: AAH17237.1
CCDSiCCDS32922.1 [O60499-1]
CCDS62571.1 [O60499-2]
PIRiJC5922
RefSeqiNP_001258540.1, NM_001271611.1 [O60499-2]
NP_003756.1, NM_003765.2 [O60499-1]
UniGeneiHs.43812

Genome annotation databases

EnsembliENST00000343587; ENSP00000339350; ENSG00000104915 [O60499-2]
ENST00000587230; ENSP00000466298; ENSG00000104915 [O60499-1]
GeneIDi8677
KEGGihsa:8677
UCSCiuc021upq.3 human [O60499-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSTX10_HUMAN
AccessioniPrimary (citable) accession number: O60499
Secondary accession number(s): A6NC41, Q6IAP4, Q96AE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health