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O60499

- STX10_HUMAN

UniProt

O60499 - STX10_HUMAN

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Protein

Syntaxin-10

Gene
STX10, SYN10
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.1 Publication

GO - Molecular functioni

  1. SNAP receptor activity Source: RefGenome

GO - Biological processi

  1. Golgi vesicle transport Source: InterPro
  2. intracellular protein transport Source: RefGenome
  3. retrograde transport, endosome to Golgi Source: UniProtKB
  4. vesicle fusion Source: RefGenome
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-10
Short name:
Syn10
Gene namesi
Name:STX10
Synonyms:SYN10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:11428. STX10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 228227Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei229 – 24921Helical; Anchor for type IV membrane protein; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: ProtInc
  2. integral component of membrane Source: RefGenome
  3. SNARE complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36228.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 249248Syntaxin-10PRO_0000210220Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei108 – 1081Phosphoserine1 Publication
Modified residuei110 – 1101Phosphothreonine1 Publication
Modified residuei134 – 1341Phosphoserine1 Publication
Modified residuei140 – 1401Phosphoserine2 Publications
Modified residuei143 – 1431Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO60499.
PaxDbiO60499.
PRIDEiO60499.

PTM databases

PhosphoSiteiO60499.

Miscellaneous databases

PMAP-CutDBO60499.

Expressioni

Tissue specificityi

Expressed at high levels in heart, skeletal muscle and pancreas.

Gene expression databases

ArrayExpressiO60499.
BgeeiO60499.
CleanExiHS_STX10.
GenevestigatoriO60499.

Organism-specific databases

HPAiHPA035303.

Interactioni

Subunit structurei

Interacts with VPS52.1 Publication

Protein-protein interaction databases

BioGridi114225. 2 interactions.
DIPiDIP-60563N.
STRINGi9606.ENSP00000242770.

Structurei

Secondary structure

1
249
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 3024
Helixi42 – 7332
Helixi75 – 784
Helixi82 – 10625

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DNDX-ray1.40A1-108[»]
ProteinModelPortaliO60499.
SMRiO60499. Positions 5-108, 164-226.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini157 – 21963t-SNARE coiled-coil homologyAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili41 – 6929 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46901.
HOGENOMiHOG000237350.
HOVERGENiHBG007194.
InParanoidiO60499.
KOiK08498.
OMAiERNNREV.
PhylomeDBiO60499.

Family and domain databases

InterProiIPR015260. Syntaxin-6_N.
IPR006012. Syntaxin/epimorphin_CS.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
PF09177. Syntaxin-6_N. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O60499-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSLEDPFFVV RGEVQKAVNT ARGLYQRWCE LLQESAAVGR EELDWTTNEL    50
RNGLRSIEWD LEDLEETIGI VEANPGKFKL PAGDLQERKV FVERMREAVQ 100
EMKDHMVSPT AVAFLERNNR EILAGKPAAQ KSPSDLLDAS AVSATSRYIE 150
EQQATQQLIM DEQDQQLEMV SGSIQVLKHM SGRVGEELDE QGIMLDAFAQ 200
EMDHTQSRMD GVLRKLAKVS HMTSDRRQWC AIAVLVGVLL LVLILLFSL 249
Length:249
Mass (Da):28,114
Last modified:August 1, 1998 - v1
Checksum:i795AB3055F25AD5F
GO
Isoform 2 (identifier: O60499-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-124: Missing.

Note: No experimental confirmation available.

Show »
Length:200
Mass (Da):22,445
Checksum:iC196F05CCAD78966
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei76 – 12449Missing in isoform 2. VSP_006347Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF035531 mRNA. Translation: AAC05087.1.
CR457110 mRNA. Translation: CAG33391.1.
AC011446 Genomic DNA. No translation available.
BC017237 mRNA. Translation: AAH17237.1.
CCDSiCCDS32922.1. [O60499-1]
CCDS62571.1. [O60499-2]
PIRiJC5922.
RefSeqiNP_001258540.1. NM_001271611.1. [O60499-2]
NP_003756.1. NM_003765.2. [O60499-1]
UniGeneiHs.43812.

Genome annotation databases

EnsembliENST00000343587; ENSP00000339350; ENSG00000104915. [O60499-2]
ENST00000587230; ENSP00000466298; ENSG00000104915. [O60499-1]
GeneIDi8677.
KEGGihsa:8677.
UCSCiuc002mwn.4. human. [O60499-1]
uc031rjq.1. human. [O60499-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF035531 mRNA. Translation: AAC05087.1 .
CR457110 mRNA. Translation: CAG33391.1 .
AC011446 Genomic DNA. No translation available.
BC017237 mRNA. Translation: AAH17237.1 .
CCDSi CCDS32922.1. [O60499-1 ]
CCDS62571.1. [O60499-2 ]
PIRi JC5922.
RefSeqi NP_001258540.1. NM_001271611.1. [O60499-2 ]
NP_003756.1. NM_003765.2. [O60499-1 ]
UniGenei Hs.43812.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4DND X-ray 1.40 A 1-108 [» ]
ProteinModelPortali O60499.
SMRi O60499. Positions 5-108, 164-226.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114225. 2 interactions.
DIPi DIP-60563N.
STRINGi 9606.ENSP00000242770.

PTM databases

PhosphoSitei O60499.

Proteomic databases

MaxQBi O60499.
PaxDbi O60499.
PRIDEi O60499.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000343587 ; ENSP00000339350 ; ENSG00000104915 . [O60499-2 ]
ENST00000587230 ; ENSP00000466298 ; ENSG00000104915 . [O60499-1 ]
GeneIDi 8677.
KEGGi hsa:8677.
UCSCi uc002mwn.4. human. [O60499-1 ]
uc031rjq.1. human. [O60499-2 ]

Organism-specific databases

CTDi 8677.
GeneCardsi GC19M013254.
HGNCi HGNC:11428. STX10.
HPAi HPA035303.
MIMi 603765. gene.
neXtProti NX_O60499.
PharmGKBi PA36228.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46901.
HOGENOMi HOG000237350.
HOVERGENi HBG007194.
InParanoidi O60499.
KOi K08498.
OMAi ERNNREV.
PhylomeDBi O60499.

Miscellaneous databases

GeneWikii STX10.
GenomeRNAii 8677.
NextBioi 32551.
PMAP-CutDB O60499.
PROi O60499.
SOURCEi Search...

Gene expression databases

ArrayExpressi O60499.
Bgeei O60499.
CleanExi HS_STX10.
Genevestigatori O60499.

Family and domain databases

InterProi IPR015260. Syntaxin-6_N.
IPR006012. Syntaxin/epimorphin_CS.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view ]
Pfami PF05739. SNARE. 1 hit.
PF09177. Syntaxin-6_N. 1 hit.
[Graphical view ]
SMARTi SM00397. t_SNARE. 1 hit.
[Graphical view ]
SUPFAMi SSF47661. SSF47661. 1 hit.
PROSITEi PS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Syntaxin 10: a member of the syntaxin family localized to the trans-Golgi network."
    Tang B.L., Low D.Y.H., Tan A.E.H., Hong W.
    Biochem. Biophys. Res. Commun. 242:345-350(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  5. Cited for: INTERACTION WITH VSP52.
  6. "A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells."
    Ganley I.G., Espinosa E., Pfeffer S.R.
    J. Cell Biol. 180:159-172(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140 AND SER-143, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-134; SER-140 AND SER-143, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108 AND THR-110, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSTX10_HUMAN
AccessioniPrimary (citable) accession number: O60499
Secondary accession number(s): A6NC41, Q6IAP4, Q96AE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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