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O60499

- STX10_HUMAN

UniProt

O60499 - STX10_HUMAN

Protein

Syntaxin-10

Gene

STX10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.1 Publication

    GO - Molecular functioni

    1. SNAP receptor activity Source: RefGenome

    GO - Biological processi

    1. Golgi vesicle transport Source: InterPro
    2. intracellular protein transport Source: RefGenome
    3. retrograde transport, endosome to Golgi Source: UniProtKB
    4. vesicle fusion Source: RefGenome

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Syntaxin-10
    Short name:
    Syn10
    Gene namesi
    Name:STX10
    Synonyms:SYN10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:11428. STX10.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: ProtInc
    2. integral component of membrane Source: RefGenome
    3. SNARE complex Source: RefGenome

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36228.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 249248Syntaxin-10PRO_0000210220Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Modified residuei108 – 1081Phosphoserine1 Publication
    Modified residuei110 – 1101Phosphothreonine1 Publication
    Modified residuei134 – 1341Phosphoserine1 Publication
    Modified residuei140 – 1401Phosphoserine2 Publications
    Modified residuei143 – 1431Phosphoserine2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO60499.
    PaxDbiO60499.
    PRIDEiO60499.

    PTM databases

    PhosphoSiteiO60499.

    Miscellaneous databases

    PMAP-CutDBO60499.

    Expressioni

    Tissue specificityi

    Expressed at high levels in heart, skeletal muscle and pancreas.

    Gene expression databases

    ArrayExpressiO60499.
    BgeeiO60499.
    CleanExiHS_STX10.
    GenevestigatoriO60499.

    Organism-specific databases

    HPAiHPA035303.

    Interactioni

    Subunit structurei

    Interacts with VPS52.1 Publication

    Protein-protein interaction databases

    BioGridi114225. 2 interactions.
    DIPiDIP-60563N.
    STRINGi9606.ENSP00000242770.

    Structurei

    Secondary structure

    1
    249
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi7 – 3024
    Helixi42 – 7332
    Helixi75 – 784
    Helixi82 – 10625

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4DNDX-ray1.40A1-108[»]
    ProteinModelPortaliO60499.
    SMRiO60499. Positions 5-108, 164-226.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 228227CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei229 – 24921Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini157 – 21963t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili41 – 6929Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the syntaxin family.Curated
    Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46901.
    HOGENOMiHOG000237350.
    HOVERGENiHBG007194.
    InParanoidiO60499.
    KOiK08498.
    OMAiERNNREV.
    PhylomeDBiO60499.

    Family and domain databases

    InterProiIPR015260. Syntaxin-6_N.
    IPR006012. Syntaxin/epimorphin_CS.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view]
    PfamiPF05739. SNARE. 1 hit.
    PF09177. Syntaxin-6_N. 1 hit.
    [Graphical view]
    SMARTiSM00397. t_SNARE. 1 hit.
    [Graphical view]
    SUPFAMiSSF47661. SSF47661. 1 hit.
    PROSITEiPS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O60499-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSLEDPFFVV RGEVQKAVNT ARGLYQRWCE LLQESAAVGR EELDWTTNEL    50
    RNGLRSIEWD LEDLEETIGI VEANPGKFKL PAGDLQERKV FVERMREAVQ 100
    EMKDHMVSPT AVAFLERNNR EILAGKPAAQ KSPSDLLDAS AVSATSRYIE 150
    EQQATQQLIM DEQDQQLEMV SGSIQVLKHM SGRVGEELDE QGIMLDAFAQ 200
    EMDHTQSRMD GVLRKLAKVS HMTSDRRQWC AIAVLVGVLL LVLILLFSL 249
    Length:249
    Mass (Da):28,114
    Last modified:August 1, 1998 - v1
    Checksum:i795AB3055F25AD5F
    GO
    Isoform 2 (identifier: O60499-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         76-124: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:200
    Mass (Da):22,445
    Checksum:iC196F05CCAD78966
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei76 – 12449Missing in isoform 2. 1 PublicationVSP_006347Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF035531 mRNA. Translation: AAC05087.1.
    CR457110 mRNA. Translation: CAG33391.1.
    AC011446 Genomic DNA. No translation available.
    BC017237 mRNA. Translation: AAH17237.1.
    CCDSiCCDS32922.1. [O60499-1]
    CCDS62571.1. [O60499-2]
    PIRiJC5922.
    RefSeqiNP_001258540.1. NM_001271611.1. [O60499-2]
    NP_003756.1. NM_003765.2. [O60499-1]
    UniGeneiHs.43812.

    Genome annotation databases

    EnsembliENST00000343587; ENSP00000339350; ENSG00000104915. [O60499-2]
    ENST00000587230; ENSP00000466298; ENSG00000104915. [O60499-1]
    GeneIDi8677.
    KEGGihsa:8677.
    UCSCiuc002mwn.4. human. [O60499-1]
    uc031rjq.1. human. [O60499-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF035531 mRNA. Translation: AAC05087.1 .
    CR457110 mRNA. Translation: CAG33391.1 .
    AC011446 Genomic DNA. No translation available.
    BC017237 mRNA. Translation: AAH17237.1 .
    CCDSi CCDS32922.1. [O60499-1 ]
    CCDS62571.1. [O60499-2 ]
    PIRi JC5922.
    RefSeqi NP_001258540.1. NM_001271611.1. [O60499-2 ]
    NP_003756.1. NM_003765.2. [O60499-1 ]
    UniGenei Hs.43812.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4DND X-ray 1.40 A 1-108 [» ]
    ProteinModelPortali O60499.
    SMRi O60499. Positions 5-108, 164-226.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114225. 2 interactions.
    DIPi DIP-60563N.
    STRINGi 9606.ENSP00000242770.

    PTM databases

    PhosphoSitei O60499.

    Proteomic databases

    MaxQBi O60499.
    PaxDbi O60499.
    PRIDEi O60499.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000343587 ; ENSP00000339350 ; ENSG00000104915 . [O60499-2 ]
    ENST00000587230 ; ENSP00000466298 ; ENSG00000104915 . [O60499-1 ]
    GeneIDi 8677.
    KEGGi hsa:8677.
    UCSCi uc002mwn.4. human. [O60499-1 ]
    uc031rjq.1. human. [O60499-2 ]

    Organism-specific databases

    CTDi 8677.
    GeneCardsi GC19M013254.
    HGNCi HGNC:11428. STX10.
    HPAi HPA035303.
    MIMi 603765. gene.
    neXtProti NX_O60499.
    PharmGKBi PA36228.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46901.
    HOGENOMi HOG000237350.
    HOVERGENi HBG007194.
    InParanoidi O60499.
    KOi K08498.
    OMAi ERNNREV.
    PhylomeDBi O60499.

    Miscellaneous databases

    GeneWikii STX10.
    GenomeRNAii 8677.
    NextBioi 32551.
    PMAP-CutDB O60499.
    PROi O60499.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60499.
    Bgeei O60499.
    CleanExi HS_STX10.
    Genevestigatori O60499.

    Family and domain databases

    InterProi IPR015260. Syntaxin-6_N.
    IPR006012. Syntaxin/epimorphin_CS.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view ]
    Pfami PF05739. SNARE. 1 hit.
    PF09177. Syntaxin-6_N. 1 hit.
    [Graphical view ]
    SMARTi SM00397. t_SNARE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47661. SSF47661. 1 hit.
    PROSITEi PS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Syntaxin 10: a member of the syntaxin family localized to the trans-Golgi network."
      Tang B.L., Low D.Y.H., Tan A.E.H., Hong W.
      Biochem. Biophys. Res. Commun. 242:345-350(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    5. Cited for: INTERACTION WITH VSP52.
    6. "A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells."
      Ganley I.G., Espinosa E., Pfeffer S.R.
      J. Cell Biol. 180:159-172(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140 AND SER-143, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-134; SER-140 AND SER-143, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108 AND THR-110, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSTX10_HUMAN
    AccessioniPrimary (citable) accession number: O60499
    Secondary accession number(s): A6NC41, Q6IAP4, Q96AE8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3