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O60493

- SNX3_HUMAN

UniProt

O60493 - SNX3_HUMAN

Protein

Sorting nexin-3

Gene

SNX3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Plays a role in protein transport between cellular compartments. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G By similarity. Not involved in EGFR degradation.By similarity2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei70 – 701Phosphatidylinositol 3-phosphateBy similarity
    Binding sitei72 – 721Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei95 – 951Phosphatidylinositol 3-phosphateBy similarity
    Binding sitei118 – 1181Phosphatidylinositol 3-phosphateBy similarity

    GO - Molecular functioni

    1. phosphatidylinositol-3-phosphate binding Source: UniProtKB
    2. protein binding Source: IntAct
    3. protein phosphatase binding Source: UniProtKB

    GO - Biological processi

    1. endocytosis Source: ProtInc
    2. hemoglobin biosynthetic process Source: RefGenome
    3. intracellular protein transport Source: RefGenome

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    Lipid-binding

    Enzyme and pathway databases

    ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sorting nexin-3
    Alternative name(s):
    Protein SDP3
    Gene namesi
    Name:SNX3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:11174. SNX3.

    Subcellular locationi

    Early endosome 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: HGNC
    2. cytosol Source: Reactome
    3. early endosome Source: UniProtKB
    4. endosome membrane Source: UniProtKB
    5. extracellular vesicular exosome Source: UniProt
    6. intracellular membrane-bounded organelle Source: HPA

    Keywords - Cellular componenti

    Endosome

    Pathology & Biotechi

    Involvement in diseasei

    Microphthalmia, syndromic, 8 (MCOPS8) [MIM:601349]: A very rare congenital syndrome characterized by microcephaly, microphthalmia, ectrodactyly of the lower limbs and prognathism. Intellectual deficit has been reported. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities.1 Publication
    Note: The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving SNX3 has been found in patients with syndromic microphthalmia. Translocation t(6;13)(q21;q12).

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi69 – 713RRY → AAA: Abolishes binding to phosphatidylinositol 3-phosphate.
    Mutagenesisi71 – 711Y → A: Abolishes binding to phosphatidylinositol 3-phosphate. 1 Publication

    Keywords - Diseasei

    Microphthalmia

    Organism-specific databases

    MIMi601349. phenotype.
    Orphaneti3434. MMEP syndrome.
    PharmGKBiPA36013.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 162161Sorting nexin-3PRO_0000213840Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine2 Publications
    Modified residuei72 – 721Phosphoserine2 Publications

    Post-translational modificationi

    Ubiquitinated, leading to its proteasomal degradation. Deubiquitinated by USP10 By similarity.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiO60493.
    PaxDbiO60493.
    PRIDEiO60493.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00815770.
    UCD-2DPAGEO60493.

    PTM databases

    PhosphoSiteiO60493.

    Expressioni

    Gene expression databases

    BgeeiO60493.
    CleanExiHS_SNX3.
    GenevestigatoriO60493.

    Organism-specific databases

    HPAiHPA028638.

    Interactioni

    Subunit structurei

    Interacts with USP10 and SCNN1A.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CRKP461082EBI-727209,EBI-886

    Protein-protein interaction databases

    BioGridi114263. 30 interactions.
    IntActiO60493. 9 interactions.
    MINTiMINT-1421811.

    Structurei

    Secondary structure

    1
    162
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi29 – 346
    Helixi44 – 463
    Beta strandi49 – 557
    Beta strandi63 – 697
    Helixi71 – 8414
    Helixi114 – 13118
    Helixi133 – 1364
    Helixi139 – 1468

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YPSX-ray2.60A/B/C/D24-155[»]
    ProteinModelPortaliO60493.
    SMRiO60493. Positions 24-148.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 151125PXPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The PX domain mediates specific binding to phosphatidylinositol 3-phosphate (PtdIns(P3)).1 Publication

    Sequence similaritiesi

    Belongs to the sorting nexin family.Curated
    Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5391.
    HOVERGENiHBG055338.
    InParanoidiO60493.
    KOiK17918.
    OMAiEVIDKNY.
    OrthoDBiEOG7GJ6G1.
    PhylomeDBiO60493.
    TreeFamiTF314980.

    Family and domain databases

    Gene3Di3.30.1520.10. 1 hit.
    InterProiIPR001683. Phox.
    [Graphical view]
    PfamiPF00787. PX. 1 hit.
    [Graphical view]
    SMARTiSM00312. PX. 1 hit.
    [Graphical view]
    SUPFAMiSSF64268. SSF64268. 1 hit.
    PROSITEiPS50195. PX. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O60493-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAETVADTRR LITKPQNLND AYGPPSNFLE IDVSNPQTVG VGRGRFTTYE    50
    IRVKTNLPIF KLKESTVRRR YSDFEWLRSE LERESKVVVP PLPGKAFLRQ 100
    LPFRGDDGIF DDNFIEERKQ GLEQFINKVA GHPLAQNERC LHMFLQDEII 150
    DKSYTPSKIR HA 162
    Length:162
    Mass (Da):18,762
    Last modified:January 23, 2007 - v3
    Checksum:i983D422FCA6E07BC
    GO
    Isoform 2 (identifier: O60493-2) [UniParc]FASTAAdd to Basket

    Also known as: SNX 3A

    The sequence of this isoform differs from the canonical sequence as follows:
         55-86: Missing.

    Show »
    Length:130
    Mass (Da):14,766
    Checksum:i39DD7F3E916554AD
    GO
    Isoform 3 (identifier: O60493-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         87-162: VVVPPLPGKA...SYTPSKIRHA → PCLRMTSEARSHGRTWCAQNDEKLFCD

    Note: No experimental confirmation available.

    Show »
    Length:113
    Mass (Da):13,172
    Checksum:iF8C0774B88153F42
    GO
    Isoform 4 (identifier: O60493-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         33-54: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:140
    Mass (Da):16,316
    Checksum:i01710ACF7D256DCA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti100 – 1012QL → HF in AAC16018. (PubMed:11433298)Curated
    Sequence conflicti151 – 1511D → V in BAF82165. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei33 – 5422Missing in isoform 4. CuratedVSP_014694Add
    BLAST
    Alternative sequencei55 – 8632Missing in isoform 2. 1 PublicationVSP_006190Add
    BLAST
    Alternative sequencei87 – 16276VVVPP…KIRHA → PCLRMTSEARSHGRTWCAQN DEKLFCD in isoform 3. 1 PublicationVSP_012928Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF034546 mRNA. Translation: AAC16040.1.
    AF062483 mRNA. Translation: AAC16018.1.
    AB047360 mRNA. Translation: BAB32649.1.
    AK289476 mRNA. Translation: BAF82165.1.
    BT007114 mRNA. Translation: AAP35778.1.
    CR456898 mRNA. Translation: CAG33179.1.
    AL078596, Z98742 Genomic DNA. Translation: CAI20817.1.
    AL078596, Z98742 Genomic DNA. Translation: CAI20818.1.
    AL078596, Z98742 Genomic DNA. Translation: CAI20819.1.
    Z98742, AL078596 Genomic DNA. Translation: CAI95646.1.
    Z98742, AL078596 Genomic DNA. Translation: CAI95647.1.
    Z98742, AL078596 Genomic DNA. Translation: CAI95648.1.
    CH471051 Genomic DNA. Translation: EAW48378.1.
    CH471051 Genomic DNA. Translation: EAW48379.1.
    CH471051 Genomic DNA. Translation: EAW48381.1.
    CH471051 Genomic DNA. Translation: EAW48382.1.
    BC008444 mRNA. Translation: AAH08444.1.
    BC014580 mRNA. Translation: AAH14580.1.
    BC015179 mRNA. Translation: AAH15179.1.
    BC016863 mRNA. Translation: AAH16863.1.
    CCDSiCCDS5064.1. [O60493-1]
    CCDS5065.1. [O60493-2]
    RefSeqiNP_003786.1. NM_003795.4. [O60493-1]
    NP_690040.1. NM_152827.2. [O60493-2]
    XP_005267249.1. XM_005267192.1. [O60493-4]
    UniGeneiHs.12102.

    Genome annotation databases

    EnsembliENST00000230085; ENSP00000230085; ENSG00000112335. [O60493-1]
    ENST00000349379; ENSP00000296991; ENSG00000112335. [O60493-4]
    ENST00000368979; ENSP00000357975; ENSG00000112335. [O60493-3]
    ENST00000426155; ENSP00000401779; ENSG00000112335. [O60493-2]
    GeneIDi8724.
    KEGGihsa:8724.
    UCSCiuc003psh.3. human. [O60493-1]
    uc003psi.3. human. [O60493-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF034546 mRNA. Translation: AAC16040.1 .
    AF062483 mRNA. Translation: AAC16018.1 .
    AB047360 mRNA. Translation: BAB32649.1 .
    AK289476 mRNA. Translation: BAF82165.1 .
    BT007114 mRNA. Translation: AAP35778.1 .
    CR456898 mRNA. Translation: CAG33179.1 .
    AL078596 , Z98742 Genomic DNA. Translation: CAI20817.1 .
    AL078596 , Z98742 Genomic DNA. Translation: CAI20818.1 .
    AL078596 , Z98742 Genomic DNA. Translation: CAI20819.1 .
    Z98742 , AL078596 Genomic DNA. Translation: CAI95646.1 .
    Z98742 , AL078596 Genomic DNA. Translation: CAI95647.1 .
    Z98742 , AL078596 Genomic DNA. Translation: CAI95648.1 .
    CH471051 Genomic DNA. Translation: EAW48378.1 .
    CH471051 Genomic DNA. Translation: EAW48379.1 .
    CH471051 Genomic DNA. Translation: EAW48381.1 .
    CH471051 Genomic DNA. Translation: EAW48382.1 .
    BC008444 mRNA. Translation: AAH08444.1 .
    BC014580 mRNA. Translation: AAH14580.1 .
    BC015179 mRNA. Translation: AAH15179.1 .
    BC016863 mRNA. Translation: AAH16863.1 .
    CCDSi CCDS5064.1. [O60493-1 ]
    CCDS5065.1. [O60493-2 ]
    RefSeqi NP_003786.1. NM_003795.4. [O60493-1 ]
    NP_690040.1. NM_152827.2. [O60493-2 ]
    XP_005267249.1. XM_005267192.1. [O60493-4 ]
    UniGenei Hs.12102.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YPS X-ray 2.60 A/B/C/D 24-155 [» ]
    ProteinModelPortali O60493.
    SMRi O60493. Positions 24-148.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114263. 30 interactions.
    IntActi O60493. 9 interactions.
    MINTi MINT-1421811.

    PTM databases

    PhosphoSitei O60493.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00815770.
    UCD-2DPAGE O60493.

    Proteomic databases

    MaxQBi O60493.
    PaxDbi O60493.
    PRIDEi O60493.

    Protocols and materials databases

    DNASUi 8724.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000230085 ; ENSP00000230085 ; ENSG00000112335 . [O60493-1 ]
    ENST00000349379 ; ENSP00000296991 ; ENSG00000112335 . [O60493-4 ]
    ENST00000368979 ; ENSP00000357975 ; ENSG00000112335 . [O60493-3 ]
    ENST00000426155 ; ENSP00000401779 ; ENSG00000112335 . [O60493-2 ]
    GeneIDi 8724.
    KEGGi hsa:8724.
    UCSCi uc003psh.3. human. [O60493-1 ]
    uc003psi.3. human. [O60493-2 ]

    Organism-specific databases

    CTDi 8724.
    GeneCardsi GC06M108578.
    H-InvDB HIX0006117.
    HGNCi HGNC:11174. SNX3.
    HPAi HPA028638.
    MIMi 601349. phenotype.
    605930. gene.
    neXtProti NX_O60493.
    Orphaneti 3434. MMEP syndrome.
    PharmGKBi PA36013.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5391.
    HOVERGENi HBG055338.
    InParanoidi O60493.
    KOi K17918.
    OMAi EVIDKNY.
    OrthoDBi EOG7GJ6G1.
    PhylomeDBi O60493.
    TreeFami TF314980.

    Enzyme and pathway databases

    Reactomei REACT_163710. WNT ligand biogenesis and trafficking.

    Miscellaneous databases

    GeneWikii SNX3.
    GenomeRNAii 8724.
    NextBioi 32723.
    PROi O60493.
    SOURCEi Search...

    Gene expression databases

    Bgeei O60493.
    CleanExi HS_SNX3.
    Genevestigatori O60493.

    Family and domain databases

    Gene3Di 3.30.1520.10. 1 hit.
    InterProi IPR001683. Phox.
    [Graphical view ]
    Pfami PF00787. PX. 1 hit.
    [Graphical view ]
    SMARTi SM00312. PX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64268. SSF64268. 1 hit.
    PROSITEi PS50195. PX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a family of sorting nexin molecules and characterization of their association with receptors."
      Haft C.R., de la Luz Sierra M., Barr V.A., Haft D.H., Taylor S.I.
      Mol. Cell. Biol. 18:7278-7287(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P."
      Xu Y., Hortsman H., Seet L., Wong S.H., Hong W.
      Nat. Cell Biol. 3:658-666(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, PHOSPHOINOSITIDE-BINDING, DOMAIN PX, MUTAGENESIS OF 69-ARG--TYR-71 AND TYR-71.
    3. "Homo sapiens sorting nexin 3A (SNX 3A) mRNA."
      Hayama A., Uchida S., Sasaki S., Marumo F.
      Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Cerebellum.
    5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    7. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Brain, Colon, Pancreas and Skin.
    10. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
      Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-10, ACETYLATION AT ALA-2.
      Tissue: Platelet.
    11. "Sorting nexin 3 (SNX3) is disrupted in a patient with a translocation t(6;13)(q21;q12) and microcephaly, microphthalmia, ectrodactyly, prognathism (MMEP) phenotype."
      Vervoort V.S., Viljoen D., Smart R., Suthers G., DuPont B.R., Abbott A., Schwartz C.E.
      J. Med. Genet. 39:893-899(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHROMOSOMAL TRANSLOCATION, INVOLVEMENT IN MCOPS8.
    12. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies."
      Pons V., Luyet P.P., Morel E., Abrami L., van der Goot F.G., Parton R.G., Gruenberg J.
      PLoS Biol. 6:E214-E214(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "Crystal structure of the PX domain of human sorting nexin 3."
      Structural genomics consortium (SGC)
      Submitted (MAR-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 24-155.

    Entry informationi

    Entry nameiSNX3_HUMAN
    AccessioniPrimary (citable) accession number: O60493
    Secondary accession number(s): A8K0B1
    , E1P5E4, E1P5E5, O60718, Q4TT29, Q4TT31, Q5JXJ7, Q5JXJ8, Q96AP9, Q9C0J5, Q9NU45
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 135 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3