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Protein

Myelin protein zero-like protein 2

Gene

MPZL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates homophilic cell-cell adhesion.

GO - Biological processi

  • anatomical structure morphogenesis Source: ProtInc
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: ProtInc
  • T cell differentiation in thymus Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin protein zero-like protein 2
Alternative name(s):
Epithelial V-like antigen 1
Gene namesi
Name:MPZL2
Synonyms:EVA, EVA1
ORF Names:UNQ606/PRO1192
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:3496. MPZL2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 154128ExtracellularSequence AnalysisAdd
BLAST
Transmembranei155 – 17521HelicalSequence AnalysisAdd
BLAST
Topological domaini176 – 21540CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cytoskeleton Source: ProtInc
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162396145.

Polymorphism and mutation databases

BioMutaiMPZL2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 215189Myelin protein zero-like protein 2PRO_0000014756Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...)1 Publication
Disulfide bondi47 ↔ 123PROSITE-ProRule annotation
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO60487.
PaxDbiO60487.
PRIDEiO60487.

PTM databases

PhosphoSiteiO60487.

Expressioni

Tissue specificityi

Expressed in thymocytes and thymic stromal cells; expression elevated in some T-cell leukemias.

Gene expression databases

BgeeiO60487.
CleanExiHS_MPZL2.
ExpressionAtlasiO60487. baseline and differential.
GenevisibleiO60487. HS.

Organism-specific databases

HPAiHPA060740.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MPZL3Q6UWV23EBI-3906725,EBI-4314854

Protein-protein interaction databases

BioGridi115500. 4 interactions.
IntActiO60487. 4 interactions.
MINTiMINT-5003876.
STRINGi9606.ENSP00000278937.

Structurei

3D structure databases

ProteinModelPortaliO60487.
SMRiO60487. Positions 27-146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 141115Ig-like V-typeAdd
BLAST

Sequence similaritiesi

Belongs to the myelin P0 protein family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46463.
GeneTreeiENSGT00640000091161.
HOGENOMiHOG000232144.
HOVERGENiHBG107197.
InParanoidiO60487.
OMAiFSEIYFL.
OrthoDBiEOG7WQ7TN.
PhylomeDBiO60487.
TreeFamiTF331728.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR029863. MPZL2.
IPR000920. Myelin_P0_rel.
[Graphical view]
PANTHERiPTHR13869. PTHR13869. 1 hit.
PTHR13869:SF21. PTHR13869:SF21. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR00213. MYELINP0.
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60487-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYGKSSTRAV LLLLGIQLTA LWPIAAVEIY TSRVLEAVNG TDARLKCTFS
60 70 80 90 100
SFAPVGDALT VTWNFRPLDG GPEQFVFYYH IDPFQPMSGR FKDRVSWDGN
110 120 130 140 150
PERYDASILL WKLQFDDNGT YTCQVKNPPD VDGVIGEIRL SVVHTVRFSE
160 170 180 190 200
IHFLALAIGS ACALMIIIVI VVVLFQHYRK KRWAERAHKV VEIKSKEEER
210
LNQEKKVSVY LEDTD
Length:215
Mass (Da):24,484
Last modified:August 1, 1998 - v1
Checksum:i9D19EBA798B5815A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030455 mRNA. Translation: AAC39762.1.
AF275945 mRNA. Translation: AAF87240.1.
AF304447 mRNA. Translation: AAG23183.1.
AY359061 mRNA. Translation: AAQ89420.1.
AK290326 mRNA. Translation: BAF83015.1.
CH471065 Genomic DNA. Translation: EAW67358.1.
BC017774 mRNA. Translation: AAH17774.1.
CCDSiCCDS8393.1.
RefSeqiNP_005788.1. NM_005797.3.
NP_658911.1. NM_144765.2.
UniGeneiHs.116651.

Genome annotation databases

EnsembliENST00000278937; ENSP00000278937; ENSG00000149573.
ENST00000438295; ENSP00000408362; ENSG00000149573.
GeneIDi10205.
KEGGihsa:10205.
UCSCiuc001psn.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030455 mRNA. Translation: AAC39762.1.
AF275945 mRNA. Translation: AAF87240.1.
AF304447 mRNA. Translation: AAG23183.1.
AY359061 mRNA. Translation: AAQ89420.1.
AK290326 mRNA. Translation: BAF83015.1.
CH471065 Genomic DNA. Translation: EAW67358.1.
BC017774 mRNA. Translation: AAH17774.1.
CCDSiCCDS8393.1.
RefSeqiNP_005788.1. NM_005797.3.
NP_658911.1. NM_144765.2.
UniGeneiHs.116651.

3D structure databases

ProteinModelPortaliO60487.
SMRiO60487. Positions 27-146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115500. 4 interactions.
IntActiO60487. 4 interactions.
MINTiMINT-5003876.
STRINGi9606.ENSP00000278937.

PTM databases

PhosphoSiteiO60487.

Polymorphism and mutation databases

BioMutaiMPZL2.

Proteomic databases

MaxQBiO60487.
PaxDbiO60487.
PRIDEiO60487.

Protocols and materials databases

DNASUi10205.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278937; ENSP00000278937; ENSG00000149573.
ENST00000438295; ENSP00000408362; ENSG00000149573.
GeneIDi10205.
KEGGihsa:10205.
UCSCiuc001psn.3. human.

Organism-specific databases

CTDi10205.
GeneCardsiGC11M118124.
HGNCiHGNC:3496. MPZL2.
HPAiHPA060740.
MIMi604873. gene.
neXtProtiNX_O60487.
PharmGKBiPA162396145.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46463.
GeneTreeiENSGT00640000091161.
HOGENOMiHOG000232144.
HOVERGENiHBG107197.
InParanoidiO60487.
OMAiFSEIYFL.
OrthoDBiEOG7WQ7TN.
PhylomeDBiO60487.
TreeFamiTF331728.

Miscellaneous databases

GenomeRNAii10205.
NextBioi38628.
PROiO60487.
SOURCEiSearch...

Gene expression databases

BgeeiO60487.
CleanExiHS_MPZL2.
ExpressionAtlasiO60487. baseline and differential.
GenevisibleiO60487. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR029863. MPZL2.
IPR000920. Myelin_P0_rel.
[Graphical view]
PANTHERiPTHR13869. PTHR13869. 1 hit.
PTHR13869:SF21. PTHR13869:SF21. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR00213. MYELINP0.
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Epithelial V-like antigen (EVA), a novel member of the immunoglobulin superfamily, expressed in embryonic epithelia with a potential role as homotypic adhesion molecule in thymus histogenesis."
    Guttinger M., Sutti F., Panigada M., Porcellini S., Merati B., Mariani M., Teesalu T., Consalez G.G., Grassi F.
    J. Cell Biol. 141:1061-1071(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver and Spleen.
  2. "Identification of putative target genes involved in LMO2-induced leukemogenesis."
    Davenport J.W., Neale G.A.M., Goorha R.M.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Endometrial tumor.
  3. "Human EVA1 gene which is downregulated in lung carcinoma cells."
    Pietas A., Petersen I., Schluens K., Petersen S.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Squamous cell carcinoma.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-39.
    Tissue: Liver.

Entry informationi

Entry nameiMPZL2_HUMAN
AccessioniPrimary (citable) accession number: O60487
Secondary accession number(s): A8K2R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: August 1, 1998
Last modified: June 24, 2015
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.