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Protein

Myelin protein zero-like protein 2

Gene

MPZL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates homophilic cell-cell adhesion.

GO - Biological processi

  • anatomical structure morphogenesis Source: ProtInc
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: ProtInc
  • single organismal cell-cell adhesion Source: InterPro

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin protein zero-like protein 2
Alternative name(s):
Epithelial V-like antigen 1
Gene namesi
Name:MPZL2
Synonyms:EVA, EVA1
ORF Names:UNQ606/PRO1192
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149573.8.
HGNCiHGNC:3496. MPZL2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 154ExtracellularSequence analysisAdd BLAST128
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Topological domaini176 – 215CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10205.
MalaCardsiMPZL2.
OpenTargetsiENSG00000149573.
PharmGKBiPA162396145.

Polymorphism and mutation databases

BioMutaiMPZL2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001475627 – 215Myelin protein zero-like protein 2Add BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi47 ↔ 123PROSITE-ProRule annotation
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO60487.
PaxDbiO60487.
PeptideAtlasiO60487.
PRIDEiO60487.
TopDownProteomicsiO60487.

PTM databases

iPTMnetiO60487.
PhosphoSitePlusiO60487.

Expressioni

Tissue specificityi

Expressed in thymocytes and thymic stromal cells; expression elevated in some T-cell leukemias.

Gene expression databases

BgeeiENSG00000149573.
CleanExiHS_MPZL2.
ExpressionAtlasiO60487. baseline and differential.
GenevisibleiO60487. HS.

Organism-specific databases

HPAiHPA051395.
HPA060740.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MPZL3Q6UWV23EBI-3906725,EBI-4314854

Protein-protein interaction databases

BioGridi115500. 9 interactors.
IntActiO60487. 4 interactors.
MINTiMINT-5003876.
STRINGi9606.ENSP00000278937.

Structurei

3D structure databases

ProteinModelPortaliO60487.
SMRiO60487.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 141Ig-like V-typeAdd BLAST115

Sequence similaritiesi

Belongs to the myelin P0 protein family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IU94. Eukaryota.
ENOG410YKVV. LUCA.
GeneTreeiENSGT00640000091161.
HOGENOMiHOG000232144.
HOVERGENiHBG107197.
InParanoidiO60487.
OMAiVVQTVRF.
OrthoDBiEOG091G0M1V.
PhylomeDBiO60487.
TreeFamiTF331728.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR029863. MPZL2.
IPR000920. Myelin_P0-rel.
PANTHERiPTHR13869. PTHR13869. 1 hit.
PTHR13869:SF32. PTHR13869:SF32. 1 hit.
PfamiView protein in Pfam
PF07686. V-set. 1 hit.
PRINTSiPR00213. MYELINP0.
SMARTiView protein in SMART
SM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60487-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYGKSSTRAV LLLLGIQLTA LWPIAAVEIY TSRVLEAVNG TDARLKCTFS
60 70 80 90 100
SFAPVGDALT VTWNFRPLDG GPEQFVFYYH IDPFQPMSGR FKDRVSWDGN
110 120 130 140 150
PERYDASILL WKLQFDDNGT YTCQVKNPPD VDGVIGEIRL SVVHTVRFSE
160 170 180 190 200
IHFLALAIGS ACALMIIIVI VVVLFQHYRK KRWAERAHKV VEIKSKEEER
210
LNQEKKVSVY LEDTD
Length:215
Mass (Da):24,484
Last modified:August 1, 1998 - v1
Checksum:i9D19EBA798B5815A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030455 mRNA. Translation: AAC39762.1.
AF275945 mRNA. Translation: AAF87240.1.
AF304447 mRNA. Translation: AAG23183.1.
AY359061 mRNA. Translation: AAQ89420.1.
AK290326 mRNA. Translation: BAF83015.1.
CH471065 Genomic DNA. Translation: EAW67358.1.
BC017774 mRNA. Translation: AAH17774.1.
CCDSiCCDS8393.1.
RefSeqiNP_005788.1. NM_005797.3.
NP_658911.1. NM_144765.2.
UniGeneiHs.116651.

Genome annotation databases

EnsembliENST00000278937; ENSP00000278937; ENSG00000149573.
ENST00000438295; ENSP00000408362; ENSG00000149573.
GeneIDi10205.
KEGGihsa:10205.
UCSCiuc001psn.4. human.

Similar proteinsi

Entry informationi

Entry nameiMPZL2_HUMAN
AccessioniPrimary (citable) accession number: O60487
Secondary accession number(s): A8K2R1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: August 1, 1998
Last modified: September 27, 2017
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families