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O60487 (MPZL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myelin protein zero-like protein 2
Alternative name(s):
Epithelial V-like antigen 1
Gene names
Name:MPZL2
Synonyms:EVA, EVA1
ORF Names:UNQ606/PRO1192
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length215 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates homophilic cell-cell adhesion.

Subcellular location

Membrane; Single-pass type I membrane protein Probable.

Tissue specificity

Expressed in thymocytes and thymic stromal cells; expression elevated in some T-cell leukemias.

Sequence similarities

Belongs to the myelin P0 protein family.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MPZL3Q6UWV23EBI-3906725,EBI-4314854

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 215189Myelin protein zero-like protein 2
PRO_0000014756

Regions

Topological domain27 – 154128Extracellular Potential
Transmembrane155 – 17521Helical; Potential
Topological domain176 – 21540Cytoplasmic Potential
Domain27 – 141115Ig-like V-type

Amino acid modifications

Glycosylation391N-linked (GlcNAc...) Ref.8
Glycosylation1181N-linked (GlcNAc...) Potential
Disulfide bond47 ↔ 123 By similarity

Sequences

Sequence LengthMass (Da)Tools
O60487 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 9D19EBA798B5815A

FASTA21524,484
        10         20         30         40         50         60 
MYGKSSTRAV LLLLGIQLTA LWPIAAVEIY TSRVLEAVNG TDARLKCTFS SFAPVGDALT 

        70         80         90        100        110        120 
VTWNFRPLDG GPEQFVFYYH IDPFQPMSGR FKDRVSWDGN PERYDASILL WKLQFDDNGT 

       130        140        150        160        170        180 
YTCQVKNPPD VDGVIGEIRL SVVHTVRFSE IHFLALAIGS ACALMIIIVI VVVLFQHYRK 

       190        200        210 
KRWAERAHKV VEIKSKEEER LNQEKKVSVY LEDTD 

« Hide

References

« Hide 'large scale' references
[1]"Epithelial V-like antigen (EVA), a novel member of the immunoglobulin superfamily, expressed in embryonic epithelia with a potential role as homotypic adhesion molecule in thymus histogenesis."
Guttinger M., Sutti F., Panigada M., Porcellini S., Merati B., Mariani M., Teesalu T., Consalez G.G., Grassi F.
J. Cell Biol. 141:1061-1071(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver and Spleen.
[2]"Identification of putative target genes involved in LMO2-induced leukemogenesis."
Davenport J.W., Neale G.A.M., Goorha R.M.
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Endometrial tumor.
[3]"Human EVA1 gene which is downregulated in lung carcinoma cells."
Pietas A., Petersen I., Schluens K., Petersen S.
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Squamous cell carcinoma.
[4]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Tongue.
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[8]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-39.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF030455 mRNA. Translation: AAC39762.1.
AF275945 mRNA. Translation: AAF87240.1.
AF304447 mRNA. Translation: AAG23183.1.
AY359061 mRNA. Translation: AAQ89420.1.
AK290326 mRNA. Translation: BAF83015.1.
CH471065 Genomic DNA. Translation: EAW67358.1.
BC017774 mRNA. Translation: AAH17774.1.
CCDSCCDS8393.1.
RefSeqNP_005788.1. NM_005797.3.
NP_658911.1. NM_144765.2.
UniGeneHs.116651.

3D structure databases

ProteinModelPortalO60487.
SMRO60487. Positions 37-130.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115500. 4 interactions.
IntActO60487. 4 interactions.
MINTMINT-5003876.
STRING9606.ENSP00000278937.

PTM databases

PhosphoSiteO60487.

Proteomic databases

MaxQBO60487.
PaxDbO60487.
PRIDEO60487.

Protocols and materials databases

DNASU10205.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000278937; ENSP00000278937; ENSG00000149573.
ENST00000438295; ENSP00000408362; ENSG00000149573.
GeneID10205.
KEGGhsa:10205.
UCSCuc001psn.3. human.

Organism-specific databases

CTD10205.
GeneCardsGC11M118124.
HGNCHGNC:3496. MPZL2.
HPAHPA060740.
MIM604873. gene.
neXtProtNX_O60487.
PharmGKBPA162396145.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46463.
HOGENOMHOG000232144.
HOVERGENHBG107197.
InParanoidO60487.
OMAFVFYYHV.
OrthoDBEOG7WQ7TN.
PhylomeDBO60487.
TreeFamTF331728.

Gene expression databases

BgeeO60487.
CleanExHS_MPZL2.
GenevestigatorO60487.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR000920. Myelin_P0.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
PRINTSPR00213. MYELINP0.
SMARTSM00406. IGv. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi10205.
NextBio38628.
PROO60487.
SOURCESearch...

Entry information

Entry nameMPZL2_HUMAN
AccessionPrimary (citable) accession number: O60487
Secondary accession number(s): A8K2R1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM