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O60487

- MPZL2_HUMAN

UniProt

O60487 - MPZL2_HUMAN

Protein

Myelin protein zero-like protein 2

Gene

MPZL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Mediates homophilic cell-cell adhesion.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. anatomical structure morphogenesis Source: ProtInc
    2. homophilic cell adhesion Source: ProtInc
    3. single organismal cell-cell adhesion Source: Ensembl
    4. T cell differentiation in thymus Source: Ensembl

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myelin protein zero-like protein 2
    Alternative name(s):
    Epithelial V-like antigen 1
    Gene namesi
    Name:MPZL2
    Synonyms:EVA, EVA1
    ORF Names:UNQ606/PRO1192
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:3496. MPZL2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoskeleton Source: ProtInc
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162396145.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 215189Myelin protein zero-like protein 2PRO_0000014756Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi39 – 391N-linked (GlcNAc...)1 Publication
    Disulfide bondi47 ↔ 123PROSITE-ProRule annotation
    Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiO60487.
    PaxDbiO60487.
    PRIDEiO60487.

    PTM databases

    PhosphoSiteiO60487.

    Expressioni

    Tissue specificityi

    Expressed in thymocytes and thymic stromal cells; expression elevated in some T-cell leukemias.

    Gene expression databases

    BgeeiO60487.
    CleanExiHS_MPZL2.
    GenevestigatoriO60487.

    Organism-specific databases

    HPAiHPA060740.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MPZL3Q6UWV23EBI-3906725,EBI-4314854

    Protein-protein interaction databases

    BioGridi115500. 4 interactions.
    IntActiO60487. 4 interactions.
    MINTiMINT-5003876.
    STRINGi9606.ENSP00000278937.

    Structurei

    3D structure databases

    ProteinModelPortaliO60487.
    SMRiO60487. Positions 37-130.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 154128ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini176 – 21540CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei155 – 17521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 141115Ig-like V-typeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the myelin P0 protein family.Curated

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46463.
    HOGENOMiHOG000232144.
    HOVERGENiHBG107197.
    InParanoidiO60487.
    OMAiFVFYYHV.
    OrthoDBiEOG7WQ7TN.
    PhylomeDBiO60487.
    TreeFamiTF331728.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    IPR000920. Myelin_P0.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    PRINTSiPR00213. MYELINP0.
    SMARTiSM00406. IGv. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O60487-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYGKSSTRAV LLLLGIQLTA LWPIAAVEIY TSRVLEAVNG TDARLKCTFS    50
    SFAPVGDALT VTWNFRPLDG GPEQFVFYYH IDPFQPMSGR FKDRVSWDGN 100
    PERYDASILL WKLQFDDNGT YTCQVKNPPD VDGVIGEIRL SVVHTVRFSE 150
    IHFLALAIGS ACALMIIIVI VVVLFQHYRK KRWAERAHKV VEIKSKEEER 200
    LNQEKKVSVY LEDTD 215
    Length:215
    Mass (Da):24,484
    Last modified:August 1, 1998 - v1
    Checksum:i9D19EBA798B5815A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030455 mRNA. Translation: AAC39762.1.
    AF275945 mRNA. Translation: AAF87240.1.
    AF304447 mRNA. Translation: AAG23183.1.
    AY359061 mRNA. Translation: AAQ89420.1.
    AK290326 mRNA. Translation: BAF83015.1.
    CH471065 Genomic DNA. Translation: EAW67358.1.
    BC017774 mRNA. Translation: AAH17774.1.
    CCDSiCCDS8393.1.
    RefSeqiNP_005788.1. NM_005797.3.
    NP_658911.1. NM_144765.2.
    UniGeneiHs.116651.

    Genome annotation databases

    EnsembliENST00000278937; ENSP00000278937; ENSG00000149573.
    ENST00000438295; ENSP00000408362; ENSG00000149573.
    GeneIDi10205.
    KEGGihsa:10205.
    UCSCiuc001psn.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030455 mRNA. Translation: AAC39762.1 .
    AF275945 mRNA. Translation: AAF87240.1 .
    AF304447 mRNA. Translation: AAG23183.1 .
    AY359061 mRNA. Translation: AAQ89420.1 .
    AK290326 mRNA. Translation: BAF83015.1 .
    CH471065 Genomic DNA. Translation: EAW67358.1 .
    BC017774 mRNA. Translation: AAH17774.1 .
    CCDSi CCDS8393.1.
    RefSeqi NP_005788.1. NM_005797.3.
    NP_658911.1. NM_144765.2.
    UniGenei Hs.116651.

    3D structure databases

    ProteinModelPortali O60487.
    SMRi O60487. Positions 37-130.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115500. 4 interactions.
    IntActi O60487. 4 interactions.
    MINTi MINT-5003876.
    STRINGi 9606.ENSP00000278937.

    PTM databases

    PhosphoSitei O60487.

    Proteomic databases

    MaxQBi O60487.
    PaxDbi O60487.
    PRIDEi O60487.

    Protocols and materials databases

    DNASUi 10205.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000278937 ; ENSP00000278937 ; ENSG00000149573 .
    ENST00000438295 ; ENSP00000408362 ; ENSG00000149573 .
    GeneIDi 10205.
    KEGGi hsa:10205.
    UCSCi uc001psn.3. human.

    Organism-specific databases

    CTDi 10205.
    GeneCardsi GC11M118124.
    HGNCi HGNC:3496. MPZL2.
    HPAi HPA060740.
    MIMi 604873. gene.
    neXtProti NX_O60487.
    PharmGKBi PA162396145.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46463.
    HOGENOMi HOG000232144.
    HOVERGENi HBG107197.
    InParanoidi O60487.
    OMAi FVFYYHV.
    OrthoDBi EOG7WQ7TN.
    PhylomeDBi O60487.
    TreeFami TF331728.

    Miscellaneous databases

    GenomeRNAii 10205.
    NextBioi 38628.
    PROi O60487.
    SOURCEi Search...

    Gene expression databases

    Bgeei O60487.
    CleanExi HS_MPZL2.
    Genevestigatori O60487.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    IPR000920. Myelin_P0.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    PRINTSi PR00213. MYELINP0.
    SMARTi SM00406. IGv. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Epithelial V-like antigen (EVA), a novel member of the immunoglobulin superfamily, expressed in embryonic epithelia with a potential role as homotypic adhesion molecule in thymus histogenesis."
      Guttinger M., Sutti F., Panigada M., Porcellini S., Merati B., Mariani M., Teesalu T., Consalez G.G., Grassi F.
      J. Cell Biol. 141:1061-1071(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver and Spleen.
    2. "Identification of putative target genes involved in LMO2-induced leukemogenesis."
      Davenport J.W., Neale G.A.M., Goorha R.M.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Endometrial tumor.
    3. "Human EVA1 gene which is downregulated in lung carcinoma cells."
      Pietas A., Petersen I., Schluens K., Petersen S.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Squamous cell carcinoma.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tongue.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-39.
      Tissue: Liver.

    Entry informationi

    Entry nameiMPZL2_HUMAN
    AccessioniPrimary (citable) accession number: O60487
    Secondary accession number(s): A8K2R1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3