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O60487

- MPZL2_HUMAN

UniProt

O60487 - MPZL2_HUMAN

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Protein

Myelin protein zero-like protein 2

Gene
MPZL2, EVA, EVA1, UNQ606/PRO1192
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates homophilic cell-cell adhesion.

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. anatomical structure morphogenesis Source: ProtInc
  2. homophilic cell adhesion Source: ProtInc
  3. single organismal cell-cell adhesion Source: Ensembl
  4. T cell differentiation in thymus Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin protein zero-like protein 2
Alternative name(s):
Epithelial V-like antigen 1
Gene namesi
Name:MPZL2
Synonyms:EVA, EVA1
ORF Names:UNQ606/PRO1192
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:3496. MPZL2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 154128Extracellular Reviewed predictionAdd
BLAST
Transmembranei155 – 17521Helical; Reviewed predictionAdd
BLAST
Topological domaini176 – 21540Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytoskeleton Source: ProtInc
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162396145.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed predictionAdd
BLAST
Chaini27 – 215189Myelin protein zero-like protein 2PRO_0000014756Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...)1 Publication
Disulfide bondi47 ↔ 123 By similarity
Glycosylationi118 – 1181N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO60487.
PaxDbiO60487.
PRIDEiO60487.

PTM databases

PhosphoSiteiO60487.

Expressioni

Tissue specificityi

Expressed in thymocytes and thymic stromal cells; expression elevated in some T-cell leukemias.

Gene expression databases

BgeeiO60487.
CleanExiHS_MPZL2.
GenevestigatoriO60487.

Organism-specific databases

HPAiHPA060740.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MPZL3Q6UWV23EBI-3906725,EBI-4314854

Protein-protein interaction databases

BioGridi115500. 4 interactions.
IntActiO60487. 4 interactions.
MINTiMINT-5003876.
STRINGi9606.ENSP00000278937.

Structurei

3D structure databases

ProteinModelPortaliO60487.
SMRiO60487. Positions 37-130.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 141115Ig-like V-typeAdd
BLAST

Sequence similaritiesi

Belongs to the myelin P0 protein family.

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46463.
HOGENOMiHOG000232144.
HOVERGENiHBG107197.
InParanoidiO60487.
OMAiFVFYYHV.
OrthoDBiEOG7WQ7TN.
PhylomeDBiO60487.
TreeFamiTF331728.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR000920. Myelin_P0.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR00213. MYELINP0.
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60487-1 [UniParc]FASTAAdd to Basket

« Hide

MYGKSSTRAV LLLLGIQLTA LWPIAAVEIY TSRVLEAVNG TDARLKCTFS    50
SFAPVGDALT VTWNFRPLDG GPEQFVFYYH IDPFQPMSGR FKDRVSWDGN 100
PERYDASILL WKLQFDDNGT YTCQVKNPPD VDGVIGEIRL SVVHTVRFSE 150
IHFLALAIGS ACALMIIIVI VVVLFQHYRK KRWAERAHKV VEIKSKEEER 200
LNQEKKVSVY LEDTD 215
Length:215
Mass (Da):24,484
Last modified:August 1, 1998 - v1
Checksum:i9D19EBA798B5815A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF030455 mRNA. Translation: AAC39762.1.
AF275945 mRNA. Translation: AAF87240.1.
AF304447 mRNA. Translation: AAG23183.1.
AY359061 mRNA. Translation: AAQ89420.1.
AK290326 mRNA. Translation: BAF83015.1.
CH471065 Genomic DNA. Translation: EAW67358.1.
BC017774 mRNA. Translation: AAH17774.1.
CCDSiCCDS8393.1.
RefSeqiNP_005788.1. NM_005797.3.
NP_658911.1. NM_144765.2.
UniGeneiHs.116651.

Genome annotation databases

EnsembliENST00000278937; ENSP00000278937; ENSG00000149573.
ENST00000438295; ENSP00000408362; ENSG00000149573.
GeneIDi10205.
KEGGihsa:10205.
UCSCiuc001psn.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF030455 mRNA. Translation: AAC39762.1 .
AF275945 mRNA. Translation: AAF87240.1 .
AF304447 mRNA. Translation: AAG23183.1 .
AY359061 mRNA. Translation: AAQ89420.1 .
AK290326 mRNA. Translation: BAF83015.1 .
CH471065 Genomic DNA. Translation: EAW67358.1 .
BC017774 mRNA. Translation: AAH17774.1 .
CCDSi CCDS8393.1.
RefSeqi NP_005788.1. NM_005797.3.
NP_658911.1. NM_144765.2.
UniGenei Hs.116651.

3D structure databases

ProteinModelPortali O60487.
SMRi O60487. Positions 37-130.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115500. 4 interactions.
IntActi O60487. 4 interactions.
MINTi MINT-5003876.
STRINGi 9606.ENSP00000278937.

PTM databases

PhosphoSitei O60487.

Proteomic databases

MaxQBi O60487.
PaxDbi O60487.
PRIDEi O60487.

Protocols and materials databases

DNASUi 10205.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000278937 ; ENSP00000278937 ; ENSG00000149573 .
ENST00000438295 ; ENSP00000408362 ; ENSG00000149573 .
GeneIDi 10205.
KEGGi hsa:10205.
UCSCi uc001psn.3. human.

Organism-specific databases

CTDi 10205.
GeneCardsi GC11M118124.
HGNCi HGNC:3496. MPZL2.
HPAi HPA060740.
MIMi 604873. gene.
neXtProti NX_O60487.
PharmGKBi PA162396145.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46463.
HOGENOMi HOG000232144.
HOVERGENi HBG107197.
InParanoidi O60487.
OMAi FVFYYHV.
OrthoDBi EOG7WQ7TN.
PhylomeDBi O60487.
TreeFami TF331728.

Miscellaneous databases

GenomeRNAii 10205.
NextBioi 38628.
PROi O60487.
SOURCEi Search...

Gene expression databases

Bgeei O60487.
CleanExi HS_MPZL2.
Genevestigatori O60487.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR000920. Myelin_P0.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
PRINTSi PR00213. MYELINP0.
SMARTi SM00406. IGv. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Epithelial V-like antigen (EVA), a novel member of the immunoglobulin superfamily, expressed in embryonic epithelia with a potential role as homotypic adhesion molecule in thymus histogenesis."
    Guttinger M., Sutti F., Panigada M., Porcellini S., Merati B., Mariani M., Teesalu T., Consalez G.G., Grassi F.
    J. Cell Biol. 141:1061-1071(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver and Spleen.
  2. "Identification of putative target genes involved in LMO2-induced leukemogenesis."
    Davenport J.W., Neale G.A.M., Goorha R.M.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Endometrial tumor.
  3. "Human EVA1 gene which is downregulated in lung carcinoma cells."
    Pietas A., Petersen I., Schluens K., Petersen S.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Squamous cell carcinoma.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-39.
    Tissue: Liver.

Entry informationi

Entry nameiMPZL2_HUMAN
AccessioniPrimary (citable) accession number: O60487
Secondary accession number(s): A8K2R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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