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O60486 (PLXC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Plexin-C1
Alternative name(s):
Virus-encoded semaphorin protein receptor
CD_antigen=CD232
Gene names
Name:PLXNC1
Synonyms:VESPR
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1568 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 By similarity. Ref.4

Subunit structure

Monomer. Homodimer. Interacts with SEMA7A. Ref.1 Ref.4

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Tissue specificity

Detected in heart, brain, lung, spleen and placenta. Ref.1

Post-translational modification

N-glycosylated. Ref.1 Ref.4

Sequence similarities

Belongs to the plexin family.

Contains 1 Sema domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

EVM139Q8JL803EBI-2927384,EBI-2927425From a different organism.
SEMA7AO753264EBI-2927384,EBI-1753538

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 Potential
Chain35 – 15681534Plexin-C1
PRO_0000232749

Regions

Topological domain35 – 944910Extracellular Potential
Transmembrane945 – 96521Helical; Potential
Topological domain966 – 1568603Cytoplasmic Potential
Domain35 – 452418Sema

Amino acid modifications

Glycosylation861N-linked (GlcNAc...) Ref.4
Glycosylation1411N-linked (GlcNAc...) Ref.4
Glycosylation1491N-linked (GlcNAc...) Ref.4
Glycosylation2411N-linked (GlcNAc...) Ref.4
Glycosylation2521N-linked (GlcNAc...) Ref.4
Glycosylation3861N-linked (GlcNAc...) Ref.4
Glycosylation4071N-linked (GlcNAc...) Ref.4
Glycosylation5481N-linked (GlcNAc...) Potential
Glycosylation5821N-linked (GlcNAc...) Potential
Glycosylation6531N-linked (GlcNAc...) Potential
Glycosylation6921N-linked (GlcNAc...) Potential
Glycosylation7711N-linked (GlcNAc...) Potential
Glycosylation7961N-linked (GlcNAc...) Potential
Glycosylation8211N-linked (GlcNAc...) Potential
Glycosylation8901N-linked (GlcNAc...) Potential
Disulfide bond64 ↔ 87 Ref.4
Disulfide bond156 ↔ 194 Ref.4
Disulfide bond226 ↔ 354 Ref.4
Disulfide bond283 ↔ 329 Ref.4
Disulfide bond455 ↔ 472 Ref.4
Disulfide bond461 ↔ 506 Ref.4
Disulfide bond464 ↔ 481 Ref.4
Disulfide bond475 ↔ 487 Ref.4

Natural variations

Natural variant14991E → K.
Corresponds to variant rs11107500 [ dbSNP | Ensembl ].
VAR_050602

Experimental info

Sequence conflict6711K → R in BAD92171. Ref.2

Secondary structure

.............................................................................................................. 1568
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O60486 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: EA0CE5519BEF925D

FASTA1,568175,742
        10         20         30         40         50         60 
MEVSRRKAPP RPPRPAAPLP LLAYLLALAA PGRGADEPVW RSEQAIGAIA ASQEDGVFVA 

        70         80         90        100        110        120 
SGSCLDQLDY SLEHSLSRLY RDQAGNCTEP VSLAPPARPR PGSSFSKLLL PYREGAAGLG 

       130        140        150        160        170        180 
GLLLTGWTFD RGACEVRPLG NLSRNSLRNG TEVVSCHPQG STAGVVYRAG RNNRWYLAVA 

       190        200        210        220        230        240 
ATYVLPEPET ASRCNPAASD HDTAIALKDT EGRSLATQEL GRLKLCEGAG SLHFVDAFLW 

       250        260        270        280        290        300 
NGSIYFPYYP YNYTSGAATG WPSMARIAQS TEVLFQGQAS LDCGHGHPDG RRLLLSSSLV 

       310        320        330        340        350        360 
EALDVWAGVF SAAAGEGQER RSPTTTALCL FRMSEIQARA KRVSWDFKTA ESHCKEGDQP 

       370        380        390        400        410        420 
ERVQPIASST LIHSDLTSVY GTVVMNRTVL FLGTGDGQLL KVILGENLTS NCPEVIYEIK 

       430        440        450        460        470        480 
EETPVFYKLV PDPVKNIYIY LTAGKEVRRI RVANCNKHKS CSECLTATDP HCGWCHSLQR 

       490        500        510        520        530        540 
CTFQGDCVHS ENLENWLDIS SGAKKCPKIQ IIRSSKEKTT VTMVGSFSPR HSKCMVKNVD 

       550        560        570        580        590        600 
SSRELCQNKS QPNRTCTCSI PTRATYKDVS VVNVMFSFGS WNLSDRFNFT NCSSLKECPA 

       610        620        630        640        650        660 
CVETGCAWCK SARRCIHPFT ACDPSDYERN QEQCPVAVEK TSGGGRPKEN KGNRTNQALQ 

       670        680        690        700        710        720 
VFYIKSIEPQ KVSTLGKSNV IVTGANFTRA SNITMILKGT STCDKDVIQV SHVLNDTHMK 

       730        740        750        760        770        780 
FSLPSSRKEM KDVCIQFDGG NCSSVGSLSY IALPHCSLIF PATTWISGGQ NITMMGRNFD 

       790        800        810        820        830        840 
VIDNLIISHE LKGNINVSEY CVATYCGFLA PSLKSSKVRT NVTVKLRVQD TYLDCGTLQY 

       850        860        870        880        890        900 
REDPRFTGYR VESEVDTELE VKIQKENDNF NISKKDIEIT LFHGENGQLN CSFENITRNQ 

       910        920        930        940        950        960 
DLTTILCKIK GIKTASTIAN SSKKVRVKLG NLELYVEQES VPSTWYFLIV LPVLLVIVIF 

       970        980        990       1000       1010       1020 
AAVGVTRHKS KELSRKQSQQ LELLESELRK EIRDGFAELQ MDKLDVVDSF GTVPFLDYKH 

      1030       1040       1050       1060       1070       1080 
FALRTFFPES GGFTHIFTED MHNRDANDKN ESLTALDALI CNKSFLVTVI HTLEKQKNFS 

      1090       1100       1110       1120       1130       1140 
VKDRCLFASF LTIALQTKLV YLTSILEVLT RDLMEQCSNM QPKLMLRRTE SVVEKLLTNW 

      1150       1160       1170       1180       1190       1200 
MSVCLSGFLR ETVGEPFYLL VTTLNQKINK GPVDVITCKA LYTLNEDWLL WQVPEFSTVA 

      1210       1220       1230       1240       1250       1260 
LNVVFEKIPE NESADVCRNI SVNVLDCDTI GQAKEKIFQA FLSKNGSPYG LQLNEIGLEL 

      1270       1280       1290       1300       1310       1320 
QMGTRQKELL DIDSSSVILE DGITKLNTIG HYEISNGSTI KVFKKIANFT SDVEYSDDHC 

      1330       1340       1350       1360       1370       1380 
HLILPDSEAF QDVQGKRHRG KHKFKVKEMY LTKLLSTKVA IHSVLEKLFR SIWSLPNSRA 

      1390       1400       1410       1420       1430       1440 
PFAIKYFFDF LDAQAENKKI TDPDVVHIWK TNSLPLRFWV NILKNPQFVF DIKKTPHIDG 

      1450       1460       1470       1480       1490       1500 
CLSVIAQAFM DAFSLTEQQL GKEAPTNKLL YAKDIPTYKE EVKSYYKAIR DLPPLSSSEM 

      1510       1520       1530       1540       1550       1560 
EEFLTQESKK HENEFNEEVA LTEIYKYIVK YFDEILNKLE RERGLEEAQK QLLHVKVLFD 


EKKKCKWM 

« Hide

References

« Hide 'large scale' references
[1]"A poxvirus-encoded semaphorin induces cytokine production from monocytes and binds to a novel cellular semaphorin receptor, VESPR."
Comeau M.R., Johnson R., DuBose R.F., Petersen M., Gearing P., VandenBos T., Park L., Farrah T., Buller R.M., Cohen J.I., Strockbine L.D., Rauch C., Spriggs M.K.
Immunity 8:473-482(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY, GLYCOSYLATION, INTERACTION WITH VACCINIA VIRUS PROTEIN A39R AND HERPESVIRUS SEMA, TISSUE SPECIFICITY.
Tissue: Foreskin.
[2]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 358-1568.
Tissue: Brain.
[3]"Crystal structure of the ubiquitin like domain of PLXNC1."
Structural genomics consortium (SGC)
Submitted (DEC-2009) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 1198-1305.
[4]"Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1."
Liu H., Juo Z.S., Shim A.H., Focia P.J., Chen X., Garcia K.C., He X.
Cell 142:749-761(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS) OF 35-507 IN COMPLEXES WITH SEMA7A AND SMALLPOX VIRUS A39R, FUNCTION, SUBUNIT, DISULFIDE BONDS, GLYCOSYLATION AT ASN-86; ASN-141; ASN-149; ASN-241; ASN-252; ASN-386 AND ASN-407.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF030339 mRNA. Translation: AAC18823.1.
AB208934 mRNA. Translation: BAD92171.1.
CCDSCCDS9049.1.
PIRT09074.
RefSeqNP_005752.1. NM_005761.2.
UniGeneHs.584845.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3KUZX-ray2.30A/B1198-1305[»]
3NVNX-ray2.26B35-507[»]
3NVQX-ray2.40B/F35-507[»]
ProteinModelPortalO60486.
SMRO60486. Positions 37-507, 585-623, 659-826, 975-1560.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO60486. 2 interactions.
STRING9606.ENSP00000258526.

PTM databases

PhosphoSiteO60486.

Proteomic databases

MaxQBO60486.
PaxDbO60486.
PRIDEO60486.

Protocols and materials databases

DNASU10154.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000258526; ENSP00000258526; ENSG00000136040.
GeneID10154.
KEGGhsa:10154.
UCSCuc001tdc.3. human.

Organism-specific databases

CTD10154.
GeneCardsGC12P094542.
H-InvDBHIX0171620.
HGNCHGNC:9106. PLXNC1.
HPACAB026155.
MIM604259. gene.
neXtProtNX_O60486.
PharmGKBPA33432.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG239913.
HOGENOMHOG000115583.
HOVERGENHBG082153.
InParanoidO60486.
KOK06572.
OMAHNRDAND.
OrthoDBEOG75MVV8.
PhylomeDBO60486.
TreeFamTF312962.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.

Gene expression databases

ArrayExpressO60486.
BgeeO60486.
CleanExHS_PLXNC1.
GenevestigatorO60486.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProIPR013783. Ig-like_fold.
IPR002909. IPT.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 1 hit.
PF01833. TIG. 2 hits.
[Graphical view]
SMARTSM00429. IPT. 2 hits.
SM00423. PSI. 2 hits.
[Graphical view]
SUPFAMSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48350. SSF48350. 2 hits.
PROSITEPS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPLXNC1. human.
EvolutionaryTraceO60486.
GenomeRNAi10154.
NextBio38436.
PROO60486.
SOURCESearch...

Entry information

Entry namePLXC1_HUMAN
AccessionPrimary (citable) accession number: O60486
Secondary accession number(s): Q59H25
Entry history
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries