Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O60486

- PLXC1_HUMAN

UniProt

O60486 - PLXC1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Plexin-C1

Gene

PLXNC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity).By similarity

GO - Molecular functioni

  1. receptor activity Source: InterPro
  2. receptor binding Source: ProtInc

GO - Biological processi

  1. axon guidance Source: Reactome
  2. cell adhesion Source: ProtInc
  3. signal transduction Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_19200. Other semaphorin interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin-C1
Alternative name(s):
Virus-encoded semaphorin protein receptor
CD_antigen: CD232
Gene namesi
Name:PLXNC1
Synonyms:VESPR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:9106. PLXNC1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini35 – 944910ExtracellularSequence AnalysisAdd
BLAST
Transmembranei945 – 96521HelicalSequence AnalysisAdd
BLAST
Topological domaini966 – 1568603CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. intracellular Source: InterPro
  3. membrane Source: UniProtKB
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33432.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence AnalysisAdd
BLAST
Chaini35 – 15681534Plexin-C1PRO_0000232749Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi64 ↔ 871 PublicationPROSITE-ProRule annotation
Glycosylationi86 – 861N-linked (GlcNAc...)1 Publication
Glycosylationi141 – 1411N-linked (GlcNAc...)1 Publication
Glycosylationi149 – 1491N-linked (GlcNAc...)1 Publication
Disulfide bondi156 ↔ 1941 PublicationPROSITE-ProRule annotation
Disulfide bondi226 ↔ 3541 PublicationPROSITE-ProRule annotation
Glycosylationi241 – 2411N-linked (GlcNAc...)1 Publication
Glycosylationi252 – 2521N-linked (GlcNAc...)1 Publication
Disulfide bondi283 ↔ 3291 PublicationPROSITE-ProRule annotation
Glycosylationi386 – 3861N-linked (GlcNAc...)1 Publication
Glycosylationi407 – 4071N-linked (GlcNAc...)1 Publication
Disulfide bondi455 ↔ 4721 PublicationPROSITE-ProRule annotation
Disulfide bondi461 ↔ 5061 PublicationPROSITE-ProRule annotation
Disulfide bondi464 ↔ 4811 PublicationPROSITE-ProRule annotation
Disulfide bondi475 ↔ 4871 PublicationPROSITE-ProRule annotation
Glycosylationi548 – 5481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi582 – 5821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi653 – 6531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi692 – 6921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi771 – 7711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi796 – 7961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi821 – 8211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi890 – 8901N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO60486.
PaxDbiO60486.
PRIDEiO60486.

PTM databases

PhosphoSiteiO60486.

Expressioni

Tissue specificityi

Detected in heart, brain, lung, spleen and placenta.1 Publication

Gene expression databases

BgeeiO60486.
CleanExiHS_PLXNC1.
ExpressionAtlasiO60486. baseline and differential.
GenevestigatoriO60486.

Organism-specific databases

HPAiCAB026155.

Interactioni

Subunit structurei

Monomer. Homodimer. Interacts with SEMA7A.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
EVM139Q8JL803EBI-2927384,EBI-2927425From a different organism.
SEMA7AO753264EBI-2927384,EBI-1753538

Protein-protein interaction databases

IntActiO60486. 2 interactions.
STRINGi9606.ENSP00000258526.

Structurei

Secondary structure

1
1568
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi39 – 413Combined sources
Beta strandi48 – 514Combined sources
Beta strandi53 – 553Combined sources
Beta strandi57 – 604Combined sources
Beta strandi62 – 687Combined sources
Beta strandi75 – 8511Combined sources
Beta strandi98 – 1003Combined sources
Beta strandi105 – 1139Combined sources
Beta strandi117 – 1193Combined sources
Beta strandi122 – 1287Combined sources
Helixi129 – 1324Combined sources
Beta strandi134 – 1407Combined sources
Beta strandi149 – 1546Combined sources
Beta strandi162 – 1698Combined sources
Turni170 – 1734Combined sources
Beta strandi174 – 1818Combined sources
Turni190 – 1923Combined sources
Helixi198 – 2003Combined sources
Beta strandi203 – 21210Combined sources
Helixi213 – 2153Combined sources
Beta strandi221 – 2255Combined sources
Beta strandi232 – 2343Combined sources
Beta strandi238 – 2403Combined sources
Beta strandi241 – 25212Combined sources
Turni253 – 2564Combined sources
Beta strandi263 – 27210Combined sources
Beta strandi275 – 2817Combined sources
Beta strandi293 – 2997Combined sources
Turni301 – 3033Combined sources
Beta strandi305 – 3117Combined sources
Beta strandi316 – 3183Combined sources
Beta strandi325 – 3328Combined sources
Helixi333 – 3397Combined sources
Beta strandi345 – 3473Combined sources
Beta strandi350 – 3523Combined sources
Beta strandi354 – 3574Combined sources
Beta strandi361 – 3633Combined sources
Turni367 – 3693Combined sources
Beta strandi371 – 39424Combined sources
Beta strandi397 – 4037Combined sources
Beta strandi414 – 4185Combined sources
Beta strandi438 – 4436Combined sources
Beta strandi446 – 4527Combined sources
Helixi455 – 4573Combined sources
Helixi461 – 4655Combined sources
Beta strandi472 – 4754Combined sources
Turni476 – 4794Combined sources
Beta strandi480 – 4834Combined sources
Helixi484 – 4863Combined sources
Beta strandi491 – 4933Combined sources
Turni499 – 5013Combined sources
Helixi503 – 5053Combined sources
Beta strandi1198 – 12058Combined sources
Beta strandi1219 – 12257Combined sources
Helixi1230 – 124516Combined sources
Helixi1253 – 12553Combined sources
Beta strandi1256 – 12627Combined sources
Beta strandi1265 – 12695Combined sources
Helixi1290 – 12923Combined sources
Beta strandi1299 – 13046Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KUZX-ray2.30A/B1198-1305[»]
3NVNX-ray2.26B35-507[»]
3NVQX-ray2.40B/F35-507[»]
ProteinModelPortaliO60486.
SMRiO60486. Positions 37-507, 1198-1305.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60486.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 452418SemaPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the plexin family.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG239913.
GeneTreeiENSGT00760000119048.
HOGENOMiHOG000115583.
HOVERGENiHBG082153.
InParanoidiO60486.
KOiK06572.
OMAiHNRDAND.
OrthoDBiEOG75MVV8.
PhylomeDBiO60486.
TreeFamiTF312962.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR002909. IPT.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 1 hit.
PF01833. TIG. 2 hits.
[Graphical view]
SMARTiSM00429. IPT. 2 hits.
SM00423. PSI. 2 hits.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48350. SSF48350. 2 hits.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60486-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEVSRRKAPP RPPRPAAPLP LLAYLLALAA PGRGADEPVW RSEQAIGAIA
60 70 80 90 100
ASQEDGVFVA SGSCLDQLDY SLEHSLSRLY RDQAGNCTEP VSLAPPARPR
110 120 130 140 150
PGSSFSKLLL PYREGAAGLG GLLLTGWTFD RGACEVRPLG NLSRNSLRNG
160 170 180 190 200
TEVVSCHPQG STAGVVYRAG RNNRWYLAVA ATYVLPEPET ASRCNPAASD
210 220 230 240 250
HDTAIALKDT EGRSLATQEL GRLKLCEGAG SLHFVDAFLW NGSIYFPYYP
260 270 280 290 300
YNYTSGAATG WPSMARIAQS TEVLFQGQAS LDCGHGHPDG RRLLLSSSLV
310 320 330 340 350
EALDVWAGVF SAAAGEGQER RSPTTTALCL FRMSEIQARA KRVSWDFKTA
360 370 380 390 400
ESHCKEGDQP ERVQPIASST LIHSDLTSVY GTVVMNRTVL FLGTGDGQLL
410 420 430 440 450
KVILGENLTS NCPEVIYEIK EETPVFYKLV PDPVKNIYIY LTAGKEVRRI
460 470 480 490 500
RVANCNKHKS CSECLTATDP HCGWCHSLQR CTFQGDCVHS ENLENWLDIS
510 520 530 540 550
SGAKKCPKIQ IIRSSKEKTT VTMVGSFSPR HSKCMVKNVD SSRELCQNKS
560 570 580 590 600
QPNRTCTCSI PTRATYKDVS VVNVMFSFGS WNLSDRFNFT NCSSLKECPA
610 620 630 640 650
CVETGCAWCK SARRCIHPFT ACDPSDYERN QEQCPVAVEK TSGGGRPKEN
660 670 680 690 700
KGNRTNQALQ VFYIKSIEPQ KVSTLGKSNV IVTGANFTRA SNITMILKGT
710 720 730 740 750
STCDKDVIQV SHVLNDTHMK FSLPSSRKEM KDVCIQFDGG NCSSVGSLSY
760 770 780 790 800
IALPHCSLIF PATTWISGGQ NITMMGRNFD VIDNLIISHE LKGNINVSEY
810 820 830 840 850
CVATYCGFLA PSLKSSKVRT NVTVKLRVQD TYLDCGTLQY REDPRFTGYR
860 870 880 890 900
VESEVDTELE VKIQKENDNF NISKKDIEIT LFHGENGQLN CSFENITRNQ
910 920 930 940 950
DLTTILCKIK GIKTASTIAN SSKKVRVKLG NLELYVEQES VPSTWYFLIV
960 970 980 990 1000
LPVLLVIVIF AAVGVTRHKS KELSRKQSQQ LELLESELRK EIRDGFAELQ
1010 1020 1030 1040 1050
MDKLDVVDSF GTVPFLDYKH FALRTFFPES GGFTHIFTED MHNRDANDKN
1060 1070 1080 1090 1100
ESLTALDALI CNKSFLVTVI HTLEKQKNFS VKDRCLFASF LTIALQTKLV
1110 1120 1130 1140 1150
YLTSILEVLT RDLMEQCSNM QPKLMLRRTE SVVEKLLTNW MSVCLSGFLR
1160 1170 1180 1190 1200
ETVGEPFYLL VTTLNQKINK GPVDVITCKA LYTLNEDWLL WQVPEFSTVA
1210 1220 1230 1240 1250
LNVVFEKIPE NESADVCRNI SVNVLDCDTI GQAKEKIFQA FLSKNGSPYG
1260 1270 1280 1290 1300
LQLNEIGLEL QMGTRQKELL DIDSSSVILE DGITKLNTIG HYEISNGSTI
1310 1320 1330 1340 1350
KVFKKIANFT SDVEYSDDHC HLILPDSEAF QDVQGKRHRG KHKFKVKEMY
1360 1370 1380 1390 1400
LTKLLSTKVA IHSVLEKLFR SIWSLPNSRA PFAIKYFFDF LDAQAENKKI
1410 1420 1430 1440 1450
TDPDVVHIWK TNSLPLRFWV NILKNPQFVF DIKKTPHIDG CLSVIAQAFM
1460 1470 1480 1490 1500
DAFSLTEQQL GKEAPTNKLL YAKDIPTYKE EVKSYYKAIR DLPPLSSSEM
1510 1520 1530 1540 1550
EEFLTQESKK HENEFNEEVA LTEIYKYIVK YFDEILNKLE RERGLEEAQK
1560
QLLHVKVLFD EKKKCKWM
Length:1,568
Mass (Da):175,742
Last modified:August 1, 1998 - v1
Checksum:iEA0CE5519BEF925D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti671 – 6711K → R in BAD92171. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1499 – 14991E → K.
Corresponds to variant rs11107500 [ dbSNP | Ensembl ].
VAR_050602

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030339 mRNA. Translation: AAC18823.1.
AB208934 mRNA. Translation: BAD92171.1.
CCDSiCCDS9049.1.
PIRiT09074.
RefSeqiNP_005752.1. NM_005761.2.
UniGeneiHs.584845.

Genome annotation databases

EnsembliENST00000258526; ENSP00000258526; ENSG00000136040.
GeneIDi10154.
KEGGihsa:10154.
UCSCiuc001tdc.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030339 mRNA. Translation: AAC18823.1 .
AB208934 mRNA. Translation: BAD92171.1 .
CCDSi CCDS9049.1.
PIRi T09074.
RefSeqi NP_005752.1. NM_005761.2.
UniGenei Hs.584845.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3KUZ X-ray 2.30 A/B 1198-1305 [» ]
3NVN X-ray 2.26 B 35-507 [» ]
3NVQ X-ray 2.40 B/F 35-507 [» ]
ProteinModelPortali O60486.
SMRi O60486. Positions 37-507, 1198-1305.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O60486. 2 interactions.
STRINGi 9606.ENSP00000258526.

PTM databases

PhosphoSitei O60486.

Proteomic databases

MaxQBi O60486.
PaxDbi O60486.
PRIDEi O60486.

Protocols and materials databases

DNASUi 10154.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000258526 ; ENSP00000258526 ; ENSG00000136040 .
GeneIDi 10154.
KEGGi hsa:10154.
UCSCi uc001tdc.3. human.

Organism-specific databases

CTDi 10154.
GeneCardsi GC12P094542.
H-InvDB HIX0171620.
HGNCi HGNC:9106. PLXNC1.
HPAi CAB026155.
MIMi 604259. gene.
neXtProti NX_O60486.
PharmGKBi PA33432.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG239913.
GeneTreei ENSGT00760000119048.
HOGENOMi HOG000115583.
HOVERGENi HBG082153.
InParanoidi O60486.
KOi K06572.
OMAi HNRDAND.
OrthoDBi EOG75MVV8.
PhylomeDBi O60486.
TreeFami TF312962.

Enzyme and pathway databases

Reactomei REACT_19200. Other semaphorin interactions.

Miscellaneous databases

ChiTaRSi PLXNC1. human.
EvolutionaryTracei O60486.
GenomeRNAii 10154.
NextBioi 38436.
PROi O60486.
SOURCEi Search...

Gene expression databases

Bgeei O60486.
CleanExi HS_PLXNC1.
ExpressionAtlasi O60486. baseline and differential.
Genevestigatori O60486.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProi IPR013783. Ig-like_fold.
IPR002909. IPT.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
Pfami PF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 1 hit.
PF01833. TIG. 2 hits.
[Graphical view ]
SMARTi SM00429. IPT. 2 hits.
SM00423. PSI. 2 hits.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48350. SSF48350. 2 hits.
PROSITEi PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A poxvirus-encoded semaphorin induces cytokine production from monocytes and binds to a novel cellular semaphorin receptor, VESPR."
    Comeau M.R., Johnson R., DuBose R.F., Petersen M., Gearing P., VandenBos T., Park L., Farrah T., Buller R.M., Cohen J.I., Strockbine L.D., Rauch C., Spriggs M.K.
    Immunity 8:473-482(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY, GLYCOSYLATION, INTERACTION WITH VACCINIA VIRUS PROTEIN A39R AND HERPESVIRUS SEMA, TISSUE SPECIFICITY.
    Tissue: Foreskin.
  2. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 358-1568.
    Tissue: Brain.
  3. "Crystal structure of the ubiquitin like domain of PLXNC1."
    Structural genomics consortium (SGC)
    Submitted (DEC-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 1198-1305.
  4. "Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1."
    Liu H., Juo Z.S., Shim A.H., Focia P.J., Chen X., Garcia K.C., He X.
    Cell 142:749-761(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS) OF 35-507 IN COMPLEXES WITH SEMA7A AND SMALLPOX VIRUS A39R, FUNCTION, SUBUNIT, DISULFIDE BONDS, GLYCOSYLATION AT ASN-86; ASN-141; ASN-149; ASN-241; ASN-252; ASN-386 AND ASN-407.

Entry informationi

Entry nameiPLXC1_HUMAN
AccessioniPrimary (citable) accession number: O60486
Secondary accession number(s): Q59H25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: August 1, 1998
Last modified: November 26, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3