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Protein

Plexin-C1

Gene

PLXNC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity).By similarity1 Publication

GO - Molecular functioni

  • receptor binding Source: ProtInc
  • semaphorin receptor activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136040-MONOMER.
ReactomeiR-HSA-416700. Other semaphorin interactions.
SIGNORiO60486.

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin-C1
Alternative name(s):
Virus-encoded semaphorin protein receptor
CD_antigen: CD232
Gene namesi
Name:PLXNC1
Synonyms:VESPR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:9106. PLXNC1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini35 – 944ExtracellularSequence analysisAdd BLAST910
Transmembranei945 – 965HelicalSequence analysisAdd BLAST21
Topological domaini966 – 1568CytoplasmicSequence analysisAdd BLAST603

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10154.
OpenTargetsiENSG00000136040.
PharmGKBiPA33432.

Polymorphism and mutation databases

BioMutaiPLXNC1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000023274935 – 1568Plexin-C1Add BLAST1534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi64 ↔ 87PROSITE-ProRule annotation1 Publication
Glycosylationi86N-linked (GlcNAc...)1 Publication1
Glycosylationi141N-linked (GlcNAc...)1 Publication1
Glycosylationi149N-linked (GlcNAc...)1 Publication1
Disulfide bondi156 ↔ 194PROSITE-ProRule annotation1 Publication
Disulfide bondi226 ↔ 354PROSITE-ProRule annotation1 Publication
Glycosylationi241N-linked (GlcNAc...)1 Publication1
Glycosylationi252N-linked (GlcNAc...)1 Publication1
Disulfide bondi283 ↔ 329PROSITE-ProRule annotation1 Publication
Glycosylationi386N-linked (GlcNAc...)1 Publication1
Glycosylationi407N-linked (GlcNAc...)1 Publication1
Disulfide bondi455 ↔ 472PROSITE-ProRule annotation1 Publication
Disulfide bondi461 ↔ 506PROSITE-ProRule annotation1 Publication
Disulfide bondi464 ↔ 481PROSITE-ProRule annotation1 Publication
Disulfide bondi475 ↔ 487PROSITE-ProRule annotation1 Publication
Glycosylationi548N-linked (GlcNAc...)Sequence analysis1
Glycosylationi582N-linked (GlcNAc...)Sequence analysis1
Glycosylationi653N-linked (GlcNAc...)Sequence analysis1
Glycosylationi692N-linked (GlcNAc...)Sequence analysis1
Glycosylationi771N-linked (GlcNAc...)Sequence analysis1
Glycosylationi796N-linked (GlcNAc...)Sequence analysis1
Glycosylationi821N-linked (GlcNAc...)Sequence analysis1
Glycosylationi871N-linked (GlcNAc...)PROSITE-ProRule annotation1
Glycosylationi890N-linked (GlcNAc...)Sequence analysis1
Modified residuei978PhosphoserineBy similarity1

Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO60486.
MaxQBiO60486.
PaxDbiO60486.
PeptideAtlasiO60486.
PRIDEiO60486.

PTM databases

iPTMnetiO60486.
PhosphoSitePlusiO60486.
UniCarbKBiO60486.

Expressioni

Tissue specificityi

Detected in heart, brain, lung, spleen and placenta.1 Publication

Gene expression databases

BgeeiENSG00000136040.
CleanExiHS_PLXNC1.
ExpressionAtlasiO60486. baseline and differential.
GenevisibleiO60486. HS.

Organism-specific databases

HPAiCAB026155.

Interactioni

Subunit structurei

Monomer. Homodimer. Interacts with SEMA7A.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
EVM139Q8JL803EBI-2927384,EBI-2927425From a different organism.
SEMA7AO753264EBI-2927384,EBI-1753538

GO - Molecular functioni

  • receptor binding Source: ProtInc

Protein-protein interaction databases

IntActiO60486. 3 interactors.
STRINGi9606.ENSP00000258526.

Structurei

Secondary structure

11568
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi39 – 41Combined sources3
Beta strandi48 – 51Combined sources4
Beta strandi53 – 55Combined sources3
Beta strandi57 – 60Combined sources4
Beta strandi62 – 68Combined sources7
Beta strandi75 – 85Combined sources11
Beta strandi98 – 100Combined sources3
Beta strandi105 – 113Combined sources9
Beta strandi117 – 119Combined sources3
Beta strandi122 – 128Combined sources7
Helixi129 – 132Combined sources4
Beta strandi134 – 140Combined sources7
Beta strandi149 – 154Combined sources6
Beta strandi162 – 169Combined sources8
Turni170 – 173Combined sources4
Beta strandi174 – 181Combined sources8
Turni190 – 192Combined sources3
Helixi198 – 200Combined sources3
Beta strandi203 – 212Combined sources10
Helixi213 – 215Combined sources3
Beta strandi221 – 225Combined sources5
Beta strandi232 – 234Combined sources3
Beta strandi238 – 240Combined sources3
Beta strandi241 – 252Combined sources12
Turni253 – 256Combined sources4
Beta strandi263 – 272Combined sources10
Beta strandi275 – 281Combined sources7
Beta strandi293 – 299Combined sources7
Turni301 – 303Combined sources3
Beta strandi305 – 311Combined sources7
Beta strandi316 – 318Combined sources3
Beta strandi325 – 332Combined sources8
Helixi333 – 339Combined sources7
Beta strandi345 – 347Combined sources3
Beta strandi350 – 352Combined sources3
Beta strandi354 – 357Combined sources4
Beta strandi361 – 363Combined sources3
Turni367 – 369Combined sources3
Beta strandi371 – 394Combined sources24
Beta strandi397 – 403Combined sources7
Beta strandi414 – 418Combined sources5
Beta strandi438 – 443Combined sources6
Beta strandi446 – 452Combined sources7
Helixi455 – 457Combined sources3
Helixi461 – 465Combined sources5
Beta strandi472 – 475Combined sources4
Turni476 – 479Combined sources4
Beta strandi480 – 483Combined sources4
Helixi484 – 486Combined sources3
Beta strandi491 – 493Combined sources3
Turni499 – 501Combined sources3
Helixi503 – 505Combined sources3
Beta strandi1198 – 1205Combined sources8
Beta strandi1219 – 1225Combined sources7
Helixi1230 – 1245Combined sources16
Helixi1253 – 1255Combined sources3
Beta strandi1256 – 1262Combined sources7
Beta strandi1265 – 1269Combined sources5
Helixi1290 – 1292Combined sources3
Beta strandi1299 – 1304Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KUZX-ray2.30A/B1198-1305[»]
3NVNX-ray2.26B35-507[»]
3NVQX-ray2.40B/F35-507[»]
ProteinModelPortaliO60486.
SMRiO60486.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60486.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 452SemaPROSITE-ProRule annotationAdd BLAST418

Sequence similaritiesi

Belongs to the plexin family.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IN3C. Eukaryota.
ENOG41107MM. LUCA.
GeneTreeiENSGT00760000119048.
HOGENOMiHOG000115583.
HOVERGENiHBG082153.
InParanoidiO60486.
KOiK06572.
OMAiVANCNKH.
OrthoDBiEOG091G00EK.
PhylomeDBiO60486.
TreeFamiTF312962.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR002909. IPT.
IPR031148. Plexin.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR016201. PSI.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR22625. PTHR22625. 2 hits.
PfamiPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
PF01833. TIG. 2 hits.
[Graphical view]
SMARTiSM00429. IPT. 2 hits.
SM00423. PSI. 2 hits.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF48350. SSF48350. 2 hits.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60486-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVSRRKAPP RPPRPAAPLP LLAYLLALAA PGRGADEPVW RSEQAIGAIA
60 70 80 90 100
ASQEDGVFVA SGSCLDQLDY SLEHSLSRLY RDQAGNCTEP VSLAPPARPR
110 120 130 140 150
PGSSFSKLLL PYREGAAGLG GLLLTGWTFD RGACEVRPLG NLSRNSLRNG
160 170 180 190 200
TEVVSCHPQG STAGVVYRAG RNNRWYLAVA ATYVLPEPET ASRCNPAASD
210 220 230 240 250
HDTAIALKDT EGRSLATQEL GRLKLCEGAG SLHFVDAFLW NGSIYFPYYP
260 270 280 290 300
YNYTSGAATG WPSMARIAQS TEVLFQGQAS LDCGHGHPDG RRLLLSSSLV
310 320 330 340 350
EALDVWAGVF SAAAGEGQER RSPTTTALCL FRMSEIQARA KRVSWDFKTA
360 370 380 390 400
ESHCKEGDQP ERVQPIASST LIHSDLTSVY GTVVMNRTVL FLGTGDGQLL
410 420 430 440 450
KVILGENLTS NCPEVIYEIK EETPVFYKLV PDPVKNIYIY LTAGKEVRRI
460 470 480 490 500
RVANCNKHKS CSECLTATDP HCGWCHSLQR CTFQGDCVHS ENLENWLDIS
510 520 530 540 550
SGAKKCPKIQ IIRSSKEKTT VTMVGSFSPR HSKCMVKNVD SSRELCQNKS
560 570 580 590 600
QPNRTCTCSI PTRATYKDVS VVNVMFSFGS WNLSDRFNFT NCSSLKECPA
610 620 630 640 650
CVETGCAWCK SARRCIHPFT ACDPSDYERN QEQCPVAVEK TSGGGRPKEN
660 670 680 690 700
KGNRTNQALQ VFYIKSIEPQ KVSTLGKSNV IVTGANFTRA SNITMILKGT
710 720 730 740 750
STCDKDVIQV SHVLNDTHMK FSLPSSRKEM KDVCIQFDGG NCSSVGSLSY
760 770 780 790 800
IALPHCSLIF PATTWISGGQ NITMMGRNFD VIDNLIISHE LKGNINVSEY
810 820 830 840 850
CVATYCGFLA PSLKSSKVRT NVTVKLRVQD TYLDCGTLQY REDPRFTGYR
860 870 880 890 900
VESEVDTELE VKIQKENDNF NISKKDIEIT LFHGENGQLN CSFENITRNQ
910 920 930 940 950
DLTTILCKIK GIKTASTIAN SSKKVRVKLG NLELYVEQES VPSTWYFLIV
960 970 980 990 1000
LPVLLVIVIF AAVGVTRHKS KELSRKQSQQ LELLESELRK EIRDGFAELQ
1010 1020 1030 1040 1050
MDKLDVVDSF GTVPFLDYKH FALRTFFPES GGFTHIFTED MHNRDANDKN
1060 1070 1080 1090 1100
ESLTALDALI CNKSFLVTVI HTLEKQKNFS VKDRCLFASF LTIALQTKLV
1110 1120 1130 1140 1150
YLTSILEVLT RDLMEQCSNM QPKLMLRRTE SVVEKLLTNW MSVCLSGFLR
1160 1170 1180 1190 1200
ETVGEPFYLL VTTLNQKINK GPVDVITCKA LYTLNEDWLL WQVPEFSTVA
1210 1220 1230 1240 1250
LNVVFEKIPE NESADVCRNI SVNVLDCDTI GQAKEKIFQA FLSKNGSPYG
1260 1270 1280 1290 1300
LQLNEIGLEL QMGTRQKELL DIDSSSVILE DGITKLNTIG HYEISNGSTI
1310 1320 1330 1340 1350
KVFKKIANFT SDVEYSDDHC HLILPDSEAF QDVQGKRHRG KHKFKVKEMY
1360 1370 1380 1390 1400
LTKLLSTKVA IHSVLEKLFR SIWSLPNSRA PFAIKYFFDF LDAQAENKKI
1410 1420 1430 1440 1450
TDPDVVHIWK TNSLPLRFWV NILKNPQFVF DIKKTPHIDG CLSVIAQAFM
1460 1470 1480 1490 1500
DAFSLTEQQL GKEAPTNKLL YAKDIPTYKE EVKSYYKAIR DLPPLSSSEM
1510 1520 1530 1540 1550
EEFLTQESKK HENEFNEEVA LTEIYKYIVK YFDEILNKLE RERGLEEAQK
1560
QLLHVKVLFD EKKKCKWM
Length:1,568
Mass (Da):175,742
Last modified:August 1, 1998 - v1
Checksum:iEA0CE5519BEF925D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti671K → R in BAD92171 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0506021499E → K.Corresponds to variant rs11107500dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030339 mRNA. Translation: AAC18823.1.
AB208934 mRNA. Translation: BAD92171.1.
CCDSiCCDS9049.1.
PIRiT09074.
RefSeqiNP_005752.1. NM_005761.2.
UniGeneiHs.584845.

Genome annotation databases

EnsembliENST00000258526; ENSP00000258526; ENSG00000136040.
GeneIDi10154.
KEGGihsa:10154.
UCSCiuc001tdc.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030339 mRNA. Translation: AAC18823.1.
AB208934 mRNA. Translation: BAD92171.1.
CCDSiCCDS9049.1.
PIRiT09074.
RefSeqiNP_005752.1. NM_005761.2.
UniGeneiHs.584845.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KUZX-ray2.30A/B1198-1305[»]
3NVNX-ray2.26B35-507[»]
3NVQX-ray2.40B/F35-507[»]
ProteinModelPortaliO60486.
SMRiO60486.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO60486. 3 interactors.
STRINGi9606.ENSP00000258526.

PTM databases

iPTMnetiO60486.
PhosphoSitePlusiO60486.
UniCarbKBiO60486.

Polymorphism and mutation databases

BioMutaiPLXNC1.

Proteomic databases

EPDiO60486.
MaxQBiO60486.
PaxDbiO60486.
PeptideAtlasiO60486.
PRIDEiO60486.

Protocols and materials databases

DNASUi10154.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258526; ENSP00000258526; ENSG00000136040.
GeneIDi10154.
KEGGihsa:10154.
UCSCiuc001tdc.3. human.

Organism-specific databases

CTDi10154.
DisGeNETi10154.
GeneCardsiPLXNC1.
H-InvDBHIX0171620.
HGNCiHGNC:9106. PLXNC1.
HPAiCAB026155.
MIMi604259. gene.
neXtProtiNX_O60486.
OpenTargetsiENSG00000136040.
PharmGKBiPA33432.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IN3C. Eukaryota.
ENOG41107MM. LUCA.
GeneTreeiENSGT00760000119048.
HOGENOMiHOG000115583.
HOVERGENiHBG082153.
InParanoidiO60486.
KOiK06572.
OMAiVANCNKH.
OrthoDBiEOG091G00EK.
PhylomeDBiO60486.
TreeFamiTF312962.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136040-MONOMER.
ReactomeiR-HSA-416700. Other semaphorin interactions.
SIGNORiO60486.

Miscellaneous databases

ChiTaRSiPLXNC1. human.
EvolutionaryTraceiO60486.
GenomeRNAii10154.
PROiO60486.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136040.
CleanExiHS_PLXNC1.
ExpressionAtlasiO60486. baseline and differential.
GenevisibleiO60486. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR002909. IPT.
IPR031148. Plexin.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR016201. PSI.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR22625. PTHR22625. 2 hits.
PfamiPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
PF01833. TIG. 2 hits.
[Graphical view]
SMARTiSM00429. IPT. 2 hits.
SM00423. PSI. 2 hits.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF48350. SSF48350. 2 hits.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLXC1_HUMAN
AccessioniPrimary (citable) accession number: O60486
Secondary accession number(s): Q59H25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.