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O60486

- PLXC1_HUMAN

UniProt

O60486 - PLXC1_HUMAN

Protein

Plexin-C1

Gene

PLXNC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. receptor activity Source: InterPro
    3. receptor binding Source: ProtInc

    GO - Biological processi

    1. axon guidance Source: Reactome
    2. cell adhesion Source: ProtInc
    3. signal transduction Source: InterPro

    Enzyme and pathway databases

    ReactomeiREACT_19200. Other semaphorin interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Plexin-C1
    Alternative name(s):
    Virus-encoded semaphorin protein receptor
    CD_antigen: CD232
    Gene namesi
    Name:PLXNC1
    Synonyms:VESPR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:9106. PLXNC1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. intracellular Source: InterPro
    3. membrane Source: UniProtKB
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33432.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Sequence AnalysisAdd
    BLAST
    Chaini35 – 15681534Plexin-C1PRO_0000232749Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi64 ↔ 871 PublicationPROSITE-ProRule annotation
    Glycosylationi86 – 861N-linked (GlcNAc...)2 Publications
    Glycosylationi141 – 1411N-linked (GlcNAc...)2 Publications
    Glycosylationi149 – 1491N-linked (GlcNAc...)2 Publications
    Disulfide bondi156 ↔ 1941 PublicationPROSITE-ProRule annotation
    Disulfide bondi226 ↔ 3541 PublicationPROSITE-ProRule annotation
    Glycosylationi241 – 2411N-linked (GlcNAc...)2 Publications
    Glycosylationi252 – 2521N-linked (GlcNAc...)2 Publications
    Disulfide bondi283 ↔ 3291 PublicationPROSITE-ProRule annotation
    Glycosylationi386 – 3861N-linked (GlcNAc...)2 Publications
    Glycosylationi407 – 4071N-linked (GlcNAc...)2 Publications
    Disulfide bondi455 ↔ 4721 PublicationPROSITE-ProRule annotation
    Disulfide bondi461 ↔ 5061 PublicationPROSITE-ProRule annotation
    Disulfide bondi464 ↔ 4811 PublicationPROSITE-ProRule annotation
    Disulfide bondi475 ↔ 4871 PublicationPROSITE-ProRule annotation
    Glycosylationi548 – 5481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi582 – 5821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi653 – 6531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi692 – 6921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi771 – 7711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi796 – 7961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi821 – 8211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi890 – 8901N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.2 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiO60486.
    PaxDbiO60486.
    PRIDEiO60486.

    PTM databases

    PhosphoSiteiO60486.

    Expressioni

    Tissue specificityi

    Detected in heart, brain, lung, spleen and placenta.1 Publication

    Gene expression databases

    ArrayExpressiO60486.
    BgeeiO60486.
    CleanExiHS_PLXNC1.
    GenevestigatoriO60486.

    Organism-specific databases

    HPAiCAB026155.

    Interactioni

    Subunit structurei

    Monomer. Homodimer. Interacts with SEMA7A.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EVM139Q8JL803EBI-2927384,EBI-2927425From a different organism.
    SEMA7AO753264EBI-2927384,EBI-1753538

    Protein-protein interaction databases

    IntActiO60486. 2 interactions.
    STRINGi9606.ENSP00000258526.

    Structurei

    Secondary structure

    1
    1568
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi39 – 413
    Beta strandi48 – 514
    Beta strandi53 – 553
    Beta strandi57 – 604
    Beta strandi62 – 687
    Beta strandi75 – 8511
    Beta strandi98 – 1003
    Beta strandi105 – 1139
    Beta strandi117 – 1193
    Beta strandi122 – 1287
    Helixi129 – 1324
    Beta strandi134 – 1407
    Beta strandi149 – 1546
    Beta strandi162 – 1698
    Turni170 – 1734
    Beta strandi174 – 1818
    Turni190 – 1923
    Helixi198 – 2003
    Beta strandi203 – 21210
    Helixi213 – 2153
    Beta strandi221 – 2255
    Beta strandi232 – 2343
    Beta strandi238 – 2403
    Beta strandi241 – 25212
    Turni253 – 2564
    Beta strandi263 – 27210
    Beta strandi275 – 2817
    Beta strandi293 – 2997
    Turni301 – 3033
    Beta strandi305 – 3117
    Beta strandi316 – 3183
    Beta strandi325 – 3328
    Helixi333 – 3397
    Beta strandi345 – 3473
    Beta strandi350 – 3523
    Beta strandi354 – 3574
    Beta strandi361 – 3633
    Turni367 – 3693
    Beta strandi371 – 39424
    Beta strandi397 – 4037
    Beta strandi414 – 4185
    Beta strandi438 – 4436
    Beta strandi446 – 4527
    Helixi455 – 4573
    Helixi461 – 4655
    Beta strandi472 – 4754
    Turni476 – 4794
    Beta strandi480 – 4834
    Helixi484 – 4863
    Beta strandi491 – 4933
    Turni499 – 5013
    Helixi503 – 5053
    Beta strandi1198 – 12058
    Beta strandi1219 – 12257
    Helixi1230 – 124516
    Helixi1253 – 12553
    Beta strandi1256 – 12627
    Beta strandi1265 – 12695
    Helixi1290 – 12923
    Beta strandi1299 – 13046

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3KUZX-ray2.30A/B1198-1305[»]
    3NVNX-ray2.26B35-507[»]
    3NVQX-ray2.40B/F35-507[»]
    ProteinModelPortaliO60486.
    SMRiO60486. Positions 37-507, 585-623, 659-826, 975-1560.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO60486.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini35 – 944910ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini966 – 1568603CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei945 – 96521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 452418SemaPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the plexin family.Curated
    Contains 1 Sema domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG239913.
    HOGENOMiHOG000115583.
    HOVERGENiHBG082153.
    InParanoidiO60486.
    KOiK06572.
    OMAiHNRDAND.
    OrthoDBiEOG75MVV8.
    PhylomeDBiO60486.
    TreeFamiTF312962.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    2.60.40.10. 1 hit.
    InterProiIPR013783. Ig-like_fold.
    IPR002909. IPT.
    IPR016201. Plexin-like_fold.
    IPR013548. Plexin_cytoplasmic_RasGAP_dom.
    IPR002165. Plexin_repeat.
    IPR008936. Rho_GTPase_activation_prot.
    IPR001627. Semap_dom.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view]
    PfamiPF08337. Plexin_cytopl. 1 hit.
    PF01437. PSI. 1 hit.
    PF01833. TIG. 2 hits.
    [Graphical view]
    SMARTiSM00429. IPT. 2 hits.
    SM00423. PSI. 2 hits.
    [Graphical view]
    SUPFAMiSSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    SSF48350. SSF48350. 2 hits.
    PROSITEiPS51004. SEMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O60486-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEVSRRKAPP RPPRPAAPLP LLAYLLALAA PGRGADEPVW RSEQAIGAIA     50
    ASQEDGVFVA SGSCLDQLDY SLEHSLSRLY RDQAGNCTEP VSLAPPARPR 100
    PGSSFSKLLL PYREGAAGLG GLLLTGWTFD RGACEVRPLG NLSRNSLRNG 150
    TEVVSCHPQG STAGVVYRAG RNNRWYLAVA ATYVLPEPET ASRCNPAASD 200
    HDTAIALKDT EGRSLATQEL GRLKLCEGAG SLHFVDAFLW NGSIYFPYYP 250
    YNYTSGAATG WPSMARIAQS TEVLFQGQAS LDCGHGHPDG RRLLLSSSLV 300
    EALDVWAGVF SAAAGEGQER RSPTTTALCL FRMSEIQARA KRVSWDFKTA 350
    ESHCKEGDQP ERVQPIASST LIHSDLTSVY GTVVMNRTVL FLGTGDGQLL 400
    KVILGENLTS NCPEVIYEIK EETPVFYKLV PDPVKNIYIY LTAGKEVRRI 450
    RVANCNKHKS CSECLTATDP HCGWCHSLQR CTFQGDCVHS ENLENWLDIS 500
    SGAKKCPKIQ IIRSSKEKTT VTMVGSFSPR HSKCMVKNVD SSRELCQNKS 550
    QPNRTCTCSI PTRATYKDVS VVNVMFSFGS WNLSDRFNFT NCSSLKECPA 600
    CVETGCAWCK SARRCIHPFT ACDPSDYERN QEQCPVAVEK TSGGGRPKEN 650
    KGNRTNQALQ VFYIKSIEPQ KVSTLGKSNV IVTGANFTRA SNITMILKGT 700
    STCDKDVIQV SHVLNDTHMK FSLPSSRKEM KDVCIQFDGG NCSSVGSLSY 750
    IALPHCSLIF PATTWISGGQ NITMMGRNFD VIDNLIISHE LKGNINVSEY 800
    CVATYCGFLA PSLKSSKVRT NVTVKLRVQD TYLDCGTLQY REDPRFTGYR 850
    VESEVDTELE VKIQKENDNF NISKKDIEIT LFHGENGQLN CSFENITRNQ 900
    DLTTILCKIK GIKTASTIAN SSKKVRVKLG NLELYVEQES VPSTWYFLIV 950
    LPVLLVIVIF AAVGVTRHKS KELSRKQSQQ LELLESELRK EIRDGFAELQ 1000
    MDKLDVVDSF GTVPFLDYKH FALRTFFPES GGFTHIFTED MHNRDANDKN 1050
    ESLTALDALI CNKSFLVTVI HTLEKQKNFS VKDRCLFASF LTIALQTKLV 1100
    YLTSILEVLT RDLMEQCSNM QPKLMLRRTE SVVEKLLTNW MSVCLSGFLR 1150
    ETVGEPFYLL VTTLNQKINK GPVDVITCKA LYTLNEDWLL WQVPEFSTVA 1200
    LNVVFEKIPE NESADVCRNI SVNVLDCDTI GQAKEKIFQA FLSKNGSPYG 1250
    LQLNEIGLEL QMGTRQKELL DIDSSSVILE DGITKLNTIG HYEISNGSTI 1300
    KVFKKIANFT SDVEYSDDHC HLILPDSEAF QDVQGKRHRG KHKFKVKEMY 1350
    LTKLLSTKVA IHSVLEKLFR SIWSLPNSRA PFAIKYFFDF LDAQAENKKI 1400
    TDPDVVHIWK TNSLPLRFWV NILKNPQFVF DIKKTPHIDG CLSVIAQAFM 1450
    DAFSLTEQQL GKEAPTNKLL YAKDIPTYKE EVKSYYKAIR DLPPLSSSEM 1500
    EEFLTQESKK HENEFNEEVA LTEIYKYIVK YFDEILNKLE RERGLEEAQK 1550
    QLLHVKVLFD EKKKCKWM 1568
    Length:1,568
    Mass (Da):175,742
    Last modified:August 1, 1998 - v1
    Checksum:iEA0CE5519BEF925D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti671 – 6711K → R in BAD92171. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1499 – 14991E → K.
    Corresponds to variant rs11107500 [ dbSNP | Ensembl ].
    VAR_050602

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030339 mRNA. Translation: AAC18823.1.
    AB208934 mRNA. Translation: BAD92171.1.
    CCDSiCCDS9049.1.
    PIRiT09074.
    RefSeqiNP_005752.1. NM_005761.2.
    UniGeneiHs.584845.

    Genome annotation databases

    EnsembliENST00000258526; ENSP00000258526; ENSG00000136040.
    GeneIDi10154.
    KEGGihsa:10154.
    UCSCiuc001tdc.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030339 mRNA. Translation: AAC18823.1 .
    AB208934 mRNA. Translation: BAD92171.1 .
    CCDSi CCDS9049.1.
    PIRi T09074.
    RefSeqi NP_005752.1. NM_005761.2.
    UniGenei Hs.584845.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3KUZ X-ray 2.30 A/B 1198-1305 [» ]
    3NVN X-ray 2.26 B 35-507 [» ]
    3NVQ X-ray 2.40 B/F 35-507 [» ]
    ProteinModelPortali O60486.
    SMRi O60486. Positions 37-507, 585-623, 659-826, 975-1560.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O60486. 2 interactions.
    STRINGi 9606.ENSP00000258526.

    PTM databases

    PhosphoSitei O60486.

    Proteomic databases

    MaxQBi O60486.
    PaxDbi O60486.
    PRIDEi O60486.

    Protocols and materials databases

    DNASUi 10154.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000258526 ; ENSP00000258526 ; ENSG00000136040 .
    GeneIDi 10154.
    KEGGi hsa:10154.
    UCSCi uc001tdc.3. human.

    Organism-specific databases

    CTDi 10154.
    GeneCardsi GC12P094542.
    H-InvDB HIX0171620.
    HGNCi HGNC:9106. PLXNC1.
    HPAi CAB026155.
    MIMi 604259. gene.
    neXtProti NX_O60486.
    PharmGKBi PA33432.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG239913.
    HOGENOMi HOG000115583.
    HOVERGENi HBG082153.
    InParanoidi O60486.
    KOi K06572.
    OMAi HNRDAND.
    OrthoDBi EOG75MVV8.
    PhylomeDBi O60486.
    TreeFami TF312962.

    Enzyme and pathway databases

    Reactomei REACT_19200. Other semaphorin interactions.

    Miscellaneous databases

    ChiTaRSi PLXNC1. human.
    EvolutionaryTracei O60486.
    GenomeRNAii 10154.
    NextBioi 38436.
    PROi O60486.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60486.
    Bgeei O60486.
    CleanExi HS_PLXNC1.
    Genevestigatori O60486.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    2.60.40.10. 1 hit.
    InterProi IPR013783. Ig-like_fold.
    IPR002909. IPT.
    IPR016201. Plexin-like_fold.
    IPR013548. Plexin_cytoplasmic_RasGAP_dom.
    IPR002165. Plexin_repeat.
    IPR008936. Rho_GTPase_activation_prot.
    IPR001627. Semap_dom.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view ]
    Pfami PF08337. Plexin_cytopl. 1 hit.
    PF01437. PSI. 1 hit.
    PF01833. TIG. 2 hits.
    [Graphical view ]
    SMARTi SM00429. IPT. 2 hits.
    SM00423. PSI. 2 hits.
    [Graphical view ]
    SUPFAMi SSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    SSF48350. SSF48350. 2 hits.
    PROSITEi PS51004. SEMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A poxvirus-encoded semaphorin induces cytokine production from monocytes and binds to a novel cellular semaphorin receptor, VESPR."
      Comeau M.R., Johnson R., DuBose R.F., Petersen M., Gearing P., VandenBos T., Park L., Farrah T., Buller R.M., Cohen J.I., Strockbine L.D., Rauch C., Spriggs M.K.
      Immunity 8:473-482(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY, GLYCOSYLATION, INTERACTION WITH VACCINIA VIRUS PROTEIN A39R AND HERPESVIRUS SEMA, TISSUE SPECIFICITY.
      Tissue: Foreskin.
    2. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 358-1568.
      Tissue: Brain.
    3. "Crystal structure of the ubiquitin like domain of PLXNC1."
      Structural genomics consortium (SGC)
      Submitted (DEC-2009) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 1198-1305.
    4. "Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1."
      Liu H., Juo Z.S., Shim A.H., Focia P.J., Chen X., Garcia K.C., He X.
      Cell 142:749-761(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS) OF 35-507 IN COMPLEXES WITH SEMA7A AND SMALLPOX VIRUS A39R, FUNCTION, SUBUNIT, DISULFIDE BONDS, GLYCOSYLATION AT ASN-86; ASN-141; ASN-149; ASN-241; ASN-252; ASN-386 AND ASN-407.

    Entry informationi

    Entry nameiPLXC1_HUMAN
    AccessioniPrimary (citable) accession number: O60486
    Secondary accession number(s): Q59H25
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2006
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3