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Protein

Zinc finger protein ZIC 3

Gene

ZIC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri251 – 28636C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri295 – 32228C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri328 – 35225C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri358 – 38225C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri388 – 41023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: Ensembl
  • cell differentiation Source: UniProtKB-KW
  • determination of digestive tract left/right asymmetry Source: BHF-UCL
  • determination of left/right asymmetry in nervous system Source: Ensembl
  • determination of left/right symmetry Source: BHF-UCL
  • determination of liver left/right asymmetry Source: BHF-UCL
  • determination of pancreatic left/right asymmetry Source: BHF-UCL
  • heart looping Source: BHF-UCL
  • lung development Source: BHF-UCL
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • somatic stem cell population maintenance Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-2892247. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.
R-HSA-452723. Transcriptional regulation of pluripotent stem cells.
SignaLinkiO60481.
SIGNORiO60481.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZIC 3
Alternative name(s):
Zinc finger protein 203
Zinc finger protein of the cerebellum 3
Gene namesi
Name:ZIC3
Synonyms:ZNF203
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:12874. ZIC3.

Subcellular locationi

  • Nucleus
  • Cytoplasm By similarity

  • Note: Localizes in the cytoplasm in presence of MDFIC overexpression (By similarity). Translocation to the nucleus requires KPNA1 or KPNA6.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Heterotaxy, visceral, 1, X-linked (HTX1)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. Visceral heterotaxy or situs ambiguus results in randomization of the placement of visceral organs, including the heart, lungs, liver, spleen, and stomach. The organs are oriented randomly with respect to the left-right axis and with respect to one another. It can been associated with variety of congenital defects including cardiac malformations.
See also OMIM:306955
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti217 – 2171P → A in HTX1 and CHTD1; lacks DNA-binding; does not inhibit transcriptional activation and interaction with GLI3; decrease in nuclear localization. 4 Publications
Corresponds to variant rs104894963 [ dbSNP | Ensembl ].
VAR_025632
Natural varianti253 – 2531C → S in HTX1; increases strongly its cytoplasmic localization; lacks DNA-binding; does not inhibit transcriptional activation and interaction with GLI3. 3 Publications
Corresponds to variant rs104894961 [ dbSNP | Ensembl ].
VAR_025633
Natural varianti255 – 2551W → G in HTX1; decreases protein expression and transcriptional activity and increases its cytoplasmic localization. 2 Publications
Corresponds to variant rs122463168 [ dbSNP | Ensembl ].
VAR_042416
Natural varianti286 – 2861H → R in HTX1; inreases weakly its cytoplasmic localization; lacks DNA-binding; does not inhibit transcriptional activation and interaction with GLI3. 3 Publications
VAR_025634
Natural varianti323 – 3231T → M in HTX1; lacks DNA-binding; does not inhibit transcriptional activation and interaction with GLI3. 2 Publications
Corresponds to variant rs122462165 [ dbSNP | Ensembl ].
VAR_007753
Natural varianti405 – 4051K → E in HTX1; lacks DNA-binding; does not inhibit transcriptional activation and interaction with GLI3. 2 Publications
Corresponds to variant rs104894962 [ dbSNP | Ensembl ].
VAR_025635
VACTERL association X-linked with or without hydrocephalus (VACTERLX)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by a non-random association of congenital defects. Affected individuals manifest vertebral anomalies (V), anal atresia (A), cardiac malformations (C), tracheoesophageal fistula (TE), renal anomalies (R) such as urethral atresia with hydronephrosis, and limb anomalies (L) such as hexadactyly, humeral hypoplasia, radial aplasia, and proximally placed thumb. Some patients may have hydrocephalus. Some cases of VACTERL-H are associated with increased chromosome breakage and rearrangement.
See also OMIM:314390
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 461A → AAA in VACTERLX. 1 Publication
VAR_066626
Natural varianti318 – 3181H → N in VACTERLX; decrease in transcriptional activator activity; significant decrease in nuclear localization. 1 Publication
VAR_071333
Congenital heart defects, multiple types, 1, X-linked (CHTD1)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by congenital developmental abnormalities involving structures of the heart. Common defects include transposition of the great arteries, aortic stenosis, atrial septal defect, ventricular septal defect, pulmonic stenosis, and patent ductus arteriosus. The etiology of CHTD is complex, with contributions from environmental exposure, chromosomal abnormalities, and gene defects. Some patients with CHTD also have cardiac arrhythmias, which may be due to the anatomic defect itself or to surgical interventions.
See also OMIM:306955
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti109 – 1091S → C in CHTD1; does not affect its transcriptional activator activity; decrease in nuclear localization. 1 Publication
Corresponds to variant rs373628598 [ dbSNP | Ensembl ].
VAR_071332
Natural varianti217 – 2171P → A in HTX1 and CHTD1; lacks DNA-binding; does not inhibit transcriptional activation and interaction with GLI3; decrease in nuclear localization. 4 Publications
Corresponds to variant rs104894963 [ dbSNP | Ensembl ].
VAR_025632
Natural varianti447 – 4471A → G in CHTD1; Increase in transcriptional activator activity; decrease in nuclear localization. 1 Publication
VAR_071334

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi268 – 2681C → S: Increases weakly its cytoplasmic localization. 1 Publication
Mutagenesisi281 – 2811H → R: Increases its cytoplasmic localization. 1 Publication
Mutagenesisi304 – 3041R → M: Increases its cytoplasmic localization. 1 Publication
Mutagenesisi307 – 3071K → M: Increases its cytoplasmic localization. 1 Publication
Mutagenesisi310 – 3101K → M: Increases its cytoplasmic localization. 1 Publication
Mutagenesisi312 – 3121K → M: Increases its cytoplasmic localization. 1 Publication
Mutagenesisi314 – 3141K → M: Does not increase its cytoplasmic localization. 1 Publication
Mutagenesisi320 – 3201R → A: Increases its cytoplasmic localization. Does not interact with KPNA1 and KPNA6 and increases strongly its cytoplasmic localization; when associated with A-337; A-341; A-346; A-349 and A-350. 1 Publication
Mutagenesisi326 – 3261K → M: Does not increase its cytoplasmic localization. 1 Publication
Mutagenesisi337 – 3371K → A: Increases its cytoplasmic localization. Does not interact with KPNA1 and KPNA6 and increases strongly its cytoplasmic localization; when associated with A-320; A-341; A-346; A-349 and A-350. 1 Publication
Mutagenesisi341 – 3411R → A: Increases its cytoplasmic localization. Does not interact with KPNA1 and KPNA6 and increases strongly its cytoplasmic localization; when associated with A-320; A-337; A-346; A-349 and A-350. 1 Publication
Mutagenesisi346 – 3461K → A: Increases its cytoplasmic localization. Does not interact with KPNA1 and KPNA6 and increases strongly its cytoplasmic localization; when associated with A-320; A-337; A-341; A-349 and A-350. 1 Publication
Mutagenesisi349 – 3491K → A: Increases its cytoplasmic localization. Does not interacts with KPNA1 and KPNA6 and increases strongly its cytoplasmic localization; when associated with A-320; A-337; A-341; A-346 and A-350. 1 Publication
Mutagenesisi350 – 3501R → A: Increases its cytoplasmic localization. Does not interact with KPNA1 and KPNA6 and increases strongly its cytoplasmic localization; when associated with A-320; A-337; A-341; A-346 and A-349. 1 Publication
Mutagenesisi356 – 3561K → A: Does not increase its cytoplasmic localization. 1 Publication

Keywords - Diseasei

Disease mutation, Heterotaxy

Organism-specific databases

MalaCardsiZIC3.
MIMi306955. phenotype.
314390. phenotype.
Orphaneti3426. Double outlet right ventricle.
216718. Isolated congenitally uncorrected transposition of the great arteries.
157769. Situs ambiguus.
PharmGKBiPA37463.

Polymorphism and mutation databases

BioMutaiZIC3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467Zinc finger protein ZIC 3PRO_0000047250Add
BLAST

Proteomic databases

PaxDbiO60481.
PeptideAtlasiO60481.
PRIDEiO60481.

PTM databases

iPTMnetiO60481.
PhosphoSiteiO60481.

Expressioni

Gene expression databases

BgeeiENSG00000156925.
CleanExiHS_ZIC3.
GenevisibleiO60481. HS.

Organism-specific databases

HPAiHPA052936.

Interactioni

Subunit structurei

Interacts (via the C2H2-type domains 3, 4 and 5) with MDFIC (via the C2H2-type domains 3, 4 and 5); the interaction reduces its transcriptional activity (By similarity). Interacts with KPNA1 and KPNA6. Interacts (via C2H2-type domains 3, 4 and 5) with GLI3; the interaction enhances its transcriptional activity.By similarity2 Publications

Protein-protein interaction databases

BioGridi113379. 5 interactions.
IntActiO60481. 3 interactions.
STRINGi9606.ENSP00000287538.

Structurei

Secondary structure

1
467
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi261 – 2644Combined sources
Beta strandi272 – 2743Combined sources
Helixi275 – 28410Combined sources
Turni285 – 2873Combined sources
Helixi312 – 32312Combined sources
Beta strandi327 – 3293Combined sources
Turni333 – 3353Combined sources
Beta strandi338 – 3403Combined sources
Helixi342 – 3498Combined sources
Turni350 – 3523Combined sources
Beta strandi369 – 3713Combined sources
Helixi372 – 3776Combined sources
Turni380 – 3834Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EJ4NMR-A245-326[»]
2RPCNMR-A245-386[»]
ProteinModelPortaliO60481.
SMRiO60481. Positions 245-425.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60481.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi297 – 32226Nuclear localization signalAdd
BLAST
Motifi330 – 35223Nuclear localization signalAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi46 – 5510Poly-Ala
Compositional biasi87 – 9711Poly-HisAdd
BLAST

Domaini

The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation.By similarity

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri251 – 28636C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri295 – 32228C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri328 – 35225C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri358 – 38225C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri388 – 41023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118771.
HOGENOMiHOG000232057.
HOVERGENiHBG007135.
InParanoidiO60481.
KOiK18487.
OMAiKKTCDRT.
OrthoDBiEOG091G0M59.
PhylomeDBiO60481.
TreeFamiTF351425.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60481-1) [UniParc]FASTAAdd to basket
Also known as: ZIC3-A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTMLLDGGPQ FPGLGVGSFG APRHHEMPNR EPAGMGLNPF GDSTHAAAAA
60 70 80 90 100
AAAAAFKLSP AAAHDLSSGQ SSAFTPQGSG YANALGHHHH HHHHHHHTSQ
110 120 130 140 150
VPSYGGAASA AFNSTREFLF RQRSSGLSEA ASGGGQHGLF AGSASSLHAP
160 170 180 190 200
AGIPEPPSYL LFPGLHEQGA GHPSPTGHVD NNQVHLGLRG ELFGRADPYR
210 220 230 240 250
PVASPRTDPY AAGAQFPNYS PMNMNMGVNV AAHHGPGAFF RYMRQPIKQE
260 270 280 290 300
LSCKWIDEAQ LSRPKKSCDR TFSTMHELVT HVTMEHVGGP EQNNHVCYWE
310 320 330 340 350
ECPREGKSFK AKYKLVNHIR VHTGEKPFPC PFPGCGKIFA RSENLKIHKR
360 370 380 390 400
THTGEKPFKC EFEGCDRRFA NSSDRKKHMH VHTSDKPYIC KVCDKSYTHP
410 420 430 440 450
SSLRKHMKVH ESQGSDSSPA ASSGYESSTP PAIASANSKD TTKTPSAVQT
460
STSHNPGLPP NFNEWYV
Length:467
Mass (Da):50,569
Last modified:August 1, 1998 - v1
Checksum:i3150CF13C0679568
GO
Isoform 2 (identifier: O60481-2) [UniParc]FASTAAdd to basket
Also known as: ZIC3-B

The sequence of this isoform differs from the canonical sequence as follows:
     409-467: VHESQGSDSS...LPPNFNEWYV → CCPAWYPGQS...AEPTVQEMIY

Show »
Length:457
Mass (Da):50,045
Checksum:i28FFD09D87CC2AF5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171G → C Unknown pathological significance; no effect on its transcriptional activator activity or subcellular localization. 1 Publication
Corresponds to variant rs147232392 [ dbSNP | Ensembl ].
VAR_071330
Natural varianti46 – 461A → AAA in VACTERLX. 1 Publication
VAR_066626
Natural varianti53 – 531A → AA Unknown pathological significance; no effect on its transcriptional activator activity or subcellular localization. 1 Publication
VAR_071331
Natural varianti109 – 1091S → C in CHTD1; does not affect its transcriptional activator activity; decrease in nuclear localization. 1 Publication
Corresponds to variant rs373628598 [ dbSNP | Ensembl ].
VAR_071332
Natural varianti217 – 2171P → A in HTX1 and CHTD1; lacks DNA-binding; does not inhibit transcriptional activation and interaction with GLI3; decrease in nuclear localization. 4 Publications
Corresponds to variant rs104894963 [ dbSNP | Ensembl ].
VAR_025632
Natural varianti253 – 2531C → S in HTX1; increases strongly its cytoplasmic localization; lacks DNA-binding; does not inhibit transcriptional activation and interaction with GLI3. 3 Publications
Corresponds to variant rs104894961 [ dbSNP | Ensembl ].
VAR_025633
Natural varianti255 – 2551W → G in HTX1; decreases protein expression and transcriptional activity and increases its cytoplasmic localization. 2 Publications
Corresponds to variant rs122463168 [ dbSNP | Ensembl ].
VAR_042416
Natural varianti286 – 2861H → R in HTX1; inreases weakly its cytoplasmic localization; lacks DNA-binding; does not inhibit transcriptional activation and interaction with GLI3. 3 Publications
VAR_025634
Natural varianti318 – 3181H → N in VACTERLX; decrease in transcriptional activator activity; significant decrease in nuclear localization. 1 Publication
VAR_071333
Natural varianti323 – 3231T → M in HTX1; lacks DNA-binding; does not inhibit transcriptional activation and interaction with GLI3. 2 Publications
Corresponds to variant rs122462165 [ dbSNP | Ensembl ].
VAR_007753
Natural varianti405 – 4051K → E in HTX1; lacks DNA-binding; does not inhibit transcriptional activation and interaction with GLI3. 2 Publications
Corresponds to variant rs104894962 [ dbSNP | Ensembl ].
VAR_025635
Natural varianti447 – 4471A → G in CHTD1; Increase in transcriptional activator activity; decrease in nuclear localization. 1 Publication
VAR_071334

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei409 – 46759VHESQ…NEWYV → CCPAWYPGQSLIPDEELDTD VGMQQPALHNTTYPKCRVNA EPTVQEMIY in isoform 2. CuratedVSP_044010Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF028706 mRNA. Translation: AAC05594.1.
EU532020 mRNA. Translation: ACB30403.1.
AL035443 Genomic DNA. Translation: CAB41648.1.
AL035443 Genomic DNA. Translation: CAI42303.1.
BC113393 mRNA. Translation: AAI13394.1.
BC113395 mRNA. Translation: AAI13396.1.
CCDSiCCDS14663.1. [O60481-1]
RefSeqiNP_003404.1. NM_003413.3. [O60481-1]
UniGeneiHs.111227.

Genome annotation databases

EnsembliENST00000287538; ENSP00000287538; ENSG00000156925. [O60481-1]
ENST00000370606; ENSP00000359638; ENSG00000156925. [O60481-2]
GeneIDi7547.
KEGGihsa:7547.
UCSCiuc004fak.4. human. [O60481-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism, Triplet repeat expansion

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF028706 mRNA. Translation: AAC05594.1.
EU532020 mRNA. Translation: ACB30403.1.
AL035443 Genomic DNA. Translation: CAB41648.1.
AL035443 Genomic DNA. Translation: CAI42303.1.
BC113393 mRNA. Translation: AAI13394.1.
BC113395 mRNA. Translation: AAI13396.1.
CCDSiCCDS14663.1. [O60481-1]
RefSeqiNP_003404.1. NM_003413.3. [O60481-1]
UniGeneiHs.111227.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EJ4NMR-A245-326[»]
2RPCNMR-A245-386[»]
ProteinModelPortaliO60481.
SMRiO60481. Positions 245-425.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113379. 5 interactions.
IntActiO60481. 3 interactions.
STRINGi9606.ENSP00000287538.

PTM databases

iPTMnetiO60481.
PhosphoSiteiO60481.

Polymorphism and mutation databases

BioMutaiZIC3.

Proteomic databases

PaxDbiO60481.
PeptideAtlasiO60481.
PRIDEiO60481.

Protocols and materials databases

DNASUi7547.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287538; ENSP00000287538; ENSG00000156925. [O60481-1]
ENST00000370606; ENSP00000359638; ENSG00000156925. [O60481-2]
GeneIDi7547.
KEGGihsa:7547.
UCSCiuc004fak.4. human. [O60481-1]

Organism-specific databases

CTDi7547.
GeneCardsiZIC3.
HGNCiHGNC:12874. ZIC3.
HPAiHPA052936.
MalaCardsiZIC3.
MIMi300265. gene.
306955. phenotype.
314390. phenotype.
neXtProtiNX_O60481.
Orphaneti3426. Double outlet right ventricle.
216718. Isolated congenitally uncorrected transposition of the great arteries.
157769. Situs ambiguus.
PharmGKBiPA37463.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118771.
HOGENOMiHOG000232057.
HOVERGENiHBG007135.
InParanoidiO60481.
KOiK18487.
OMAiKKTCDRT.
OrthoDBiEOG091G0M59.
PhylomeDBiO60481.
TreeFamiTF351425.

Enzyme and pathway databases

ReactomeiR-HSA-2892247. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.
R-HSA-452723. Transcriptional regulation of pluripotent stem cells.
SignaLinkiO60481.
SIGNORiO60481.

Miscellaneous databases

EvolutionaryTraceiO60481.
GeneWikiiZIC3.
GenomeRNAii7547.
PROiO60481.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156925.
CleanExiHS_ZIC3.
GenevisibleiO60481. HS.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZIC3_HUMAN
AccessioniPrimary (citable) accession number: O60481
Secondary accession number(s): B2CNW4, Q14DE5, Q5JY75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.